WO2017179956A3 - 핵산필름의 제조방법과 핵산필름을 이용한 약물주입장치 - Google Patents

핵산필름의 제조방법과 핵산필름을 이용한 약물주입장치 Download PDF

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Publication number
WO2017179956A3
WO2017179956A3 PCT/KR2017/004084 KR2017004084W WO2017179956A3 WO 2017179956 A3 WO2017179956 A3 WO 2017179956A3 KR 2017004084 W KR2017004084 W KR 2017004084W WO 2017179956 A3 WO2017179956 A3 WO 2017179956A3
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WIPO (PCT)
Prior art keywords
nucleic acid
acid film
mixed solution
forming mold
manufacturing
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PCT/KR2017/004084
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English (en)
French (fr)
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WO2017179956A2 (ko
Inventor
정준호
이윤우
전소희
최준혁
최대근
이지혜
정주연
Original Assignee
한국기계연구원
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Filing date
Publication date
Priority claimed from KR1020160046275A external-priority patent/KR101713119B1/ko
Priority claimed from KR1020160117332A external-priority patent/KR20180030294A/ko
Application filed by 한국기계연구원 filed Critical 한국기계연구원
Priority to US16/091,521 priority Critical patent/US11040103B2/en
Priority to JP2018553442A priority patent/JP7034425B2/ja
Priority to EP17782711.0A priority patent/EP3443953A4/en
Priority to CN201780023886.3A priority patent/CN109640963A/zh
Publication of WO2017179956A2 publication Critical patent/WO2017179956A2/ko
Publication of WO2017179956A3 publication Critical patent/WO2017179956A3/ko
Priority to US17/322,942 priority patent/US20210268111A1/en
Priority to JP2021166239A priority patent/JP7191346B2/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C39/00—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor
    • B29C39/02—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor for making articles of definite length, i.e. discrete articles
    • B29C39/026—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor for making articles of definite length, i.e. discrete articles characterised by the shape of the surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2089/00—Use of proteins, e.g. casein, gelatine or derivatives thereof, as moulding material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/7544—Injection needles, syringes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/756—Microarticles, nanoarticles

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicinal Preparation (AREA)
  • Micromachines (AREA)

Abstract

본 발명의 일 실시예에 따른 핵산필름의 제조방법은, 증류수 또는 탈이온수에 핵산을 파우더 형태로 투입하여 혼합액을 형성하는 혼합단계와, 혼합단계를 거친 상기 혼합액을 교반하는 교반단계와, 완성되는 핵산필름의 형태에 대응하는 성형몰드에 혼합액을 도포하는 혼합액도포단계 및 성형몰드에 도포된 혼합액이 핵산필름으로 변화되도록 성형몰드에 도포된 혼합액을 건조시키는 건조단계를 포함하며, 상기 성형몰드에는 두께 방향을 향해 함몰되는 홈부;가 형성되고, 상기 건조단계를 거친 상기 핵산필름에는, 상기 홈부에 대응하여 상기 핵산필름의 일측 표면으로부터 인체의 피부를 향하도록 돌출되는 돌출부;가 형성된다.
PCT/KR2017/004084 2016-04-15 2017-04-14 핵산필름의 제조방법과 핵산필름을 이용한 약물주입장치 WO2017179956A2 (ko)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US16/091,521 US11040103B2 (en) 2016-04-15 2017-04-14 Method for manufacturing nucleic acid film and apparatus for injecting medicine using nucleic acid film
JP2018553442A JP7034425B2 (ja) 2016-04-15 2017-04-14 核酸フィルムの製造方法及び核酸フィルムを用いた薬物注入装置
EP17782711.0A EP3443953A4 (en) 2016-04-15 2017-04-14 METHOD FOR PRODUCING A NUCLEIC ACID FILM AND DEVICE FOR INJECTING MEDICINAL PRODUCTS USING A NUCLEIC ACID FILM
CN201780023886.3A CN109640963A (zh) 2016-04-15 2017-04-14 核酸膜的制备方法及利用核酸膜的药物注入装置
US17/322,942 US20210268111A1 (en) 2016-04-15 2021-05-18 Method for manufacturing nucleic acid film and apparatus for injecting medicine using nucleic acid film
JP2021166239A JP7191346B2 (ja) 2016-04-15 2021-10-08 核酸フィルムの製造方法及び核酸フィルムを用いた薬物注入装置

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR1020160046275A KR101713119B1 (ko) 2016-04-15 2016-04-15 연어핵산필름의 제조방법과, 연어핵산필름을 이용한 약물주입장치
KR10-2016-0046275 2016-04-15
KR10-2016-0117332 2016-09-12
KR1020160117332A KR20180030294A (ko) 2016-09-12 2016-09-12 핵산필름의 제조방법과 핵산필름을 이용한 약물주입장치

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US16/091,521 A-371-Of-International US11040103B2 (en) 2016-04-15 2017-04-14 Method for manufacturing nucleic acid film and apparatus for injecting medicine using nucleic acid film
US17/322,942 Division US20210268111A1 (en) 2016-04-15 2021-05-18 Method for manufacturing nucleic acid film and apparatus for injecting medicine using nucleic acid film

Publications (2)

Publication Number Publication Date
WO2017179956A2 WO2017179956A2 (ko) 2017-10-19
WO2017179956A3 true WO2017179956A3 (ko) 2017-12-07

Family

ID=60041988

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PCT/KR2017/004084 WO2017179956A2 (ko) 2016-04-15 2017-04-14 핵산필름의 제조방법과 핵산필름을 이용한 약물주입장치

Country Status (5)

Country Link
US (2) US11040103B2 (ko)
EP (1) EP3443953A4 (ko)
JP (2) JP7034425B2 (ko)
CN (1) CN109640963A (ko)
WO (1) WO2017179956A2 (ko)

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Publication number Priority date Publication date Assignee Title
JP2000325082A (ja) * 1999-05-19 2000-11-28 Mitsubishi Rayon Co Ltd 核酸固定化フィルムの積層体及びその薄片
JP2001081098A (ja) * 1999-09-09 2001-03-27 Nissei Bio Kk 紫外線照射による水不溶性ｄｎａ架橋体の製造方法と該架橋体の環境浄化材料としての利用
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KR101713119B1 (ko) * 2016-04-15 2017-03-08 한국기계연구원 연어핵산필름의 제조방법과, 연어핵산필름을 이용한 약물주입장치

Also Published As

Publication number Publication date
JP2019519472A (ja) 2019-07-11
JP2022008985A (ja) 2022-01-14
CN109640963A (zh) 2019-04-16
EP3443953A4 (en) 2020-02-05
US20210268111A1 (en) 2021-09-02
US11040103B2 (en) 2021-06-22
JP7034425B2 (ja) 2022-03-14
WO2017179956A2 (ko) 2017-10-19
EP3443953A2 (en) 2019-02-20
JP7191346B2 (ja) 2022-12-19
US20190125876A1 (en) 2019-05-02

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