WO2017146560A1 - Complément anti-âge - Google Patents

Complément anti-âge Download PDF

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Publication number
WO2017146560A1
WO2017146560A1 PCT/MX2016/000019 MX2016000019W WO2017146560A1 WO 2017146560 A1 WO2017146560 A1 WO 2017146560A1 MX 2016000019 W MX2016000019 W MX 2016000019W WO 2017146560 A1 WO2017146560 A1 WO 2017146560A1
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supplement
amount
vitamin
presentation
aging
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PCT/MX2016/000019
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English (en)
Spanish (es)
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Francisco Elías ARROYO PAZ
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Arroyo Paz Francisco Elías
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the present invention relates to the technical field of nutrition, food technology and medicine; since it provides an anti-aging supplement.
  • Anti-aging medicine is a clinical-medical specialty in the field of scientific research aimed at early detection, prevention, treatment and reversal of age. It is well documented by medical and scientific journals and employs evidence-based methodologies to carry out patient evaluations.
  • Anti-aging medicine is aimed at all people, regardless of their age, who want to improve their health, their quality of life. It is recommended for all those over 35 years of age, as prevention of aging processes and the pathologies that accompany them, regardless of whether anyone can perform a revitalization program, since all programs are fully individualized.
  • anti-aging refers exclusively to lessen, prevent, or reverse the aging process. The above is very different from the fight against the aging process itself and for this, if there is a wide range of strategies and therapies that are used today.
  • Calorie restriction and physical activity are some of the ways shown to reduce the risk of suffering from many age-related degenerative conditions.
  • anti-aging include as meaning the fact of looking and feeling more vital, that is, it is not related to the time you live or how healthy you are going to be.
  • Anti-aging nutritional supplement includes vitamins, minerals, an inflammatory support process, blood sugar / insulin, a botanical antioxidants, a methylation factor, a DNA repair agent, a fat metabolizer, an absorption promoter, a support of brain function, whole foods, a cellular energizer, a precursor of nucleotides, amino acids, a complex of fatty acids and digestive enzymes.
  • the composition provides nutritional supplements necessary for proper glycation, DNA methylation, anti-oxidation, and control of inflammatory processes
  • the composition and method of use provide an effective treatment against aging by decreasing DNA damage, increasing DNA repair, and improving the immune function of the human body.
  • compositions for use as an antioxidant such as for use as an anti-aging supplement.
  • the composition may include muscadine (Vitis rotundifolia), pomace extract having a content of at least 2% polyphenols and trans-resveratrol from a source other than muscadine with a minimum purity of at least 5%. Production methods of antioxidant compositions are also described.
  • These methods may include the combination of a muscadine pomace extract having a polyphenol content of at least 2% and resveratrol from a source other than muscadine with a minimum purity of at least 5% at a ratio in the range of 0 , 1/1 to 10/1 (weight to weight), thereby providing a composition with antioxidant activity.
  • the third document is patent application US2004770953 (A) with the title "Anti-Aging Supplement for Pet Welfare", which describes a nutritional supplement for pets, particularly canine pets, which consist essentially of antioxidant vitamins, vitamins of the B complex, bioflavonoids, chelated minerals, digestive enzymes, herbs, nutrients and essential fatty acids, amino acids and hormones.
  • One more document is the patent application GB20130014247 (A), said document has the title of "Dietary supplement in bar” and describes a bar as a nutritional dietary supplement that functions as an anti-aging comprising the following substances: one or more antioxidants, one or more more plants or plant derivatives that stimulate the endocrine system with anti-aging function and one or more organic oils as a source of at least omega 3, omega 6 and omega 9.
  • the antioxidant is preferably turmeric, fermented papaya, resveratrol, astaxanthin, green tea, ginkgo, selenium, vitamin C and E.
  • Plants or plant derivatives that stimulate the endocrine system with anti-aging function are maca, damiana, red clover, wild yam, black cohosh, soybeans, sage, ginseng, blueberries, oats, fenugreek, tribulus, taurine, guarana and saw palmetto. Vitamins, amino acids, and fish of collagen or hyaluronic acid can also be added.
  • compositions and methods related to partially hydrolyzed fucoidan are described for use in dietary supplements.
  • Fucoidan brown seaweed is partially hydrolyzed and then mixed with other ingredients for use as a dietary supplement in beverage, capsule, or tablet form.
  • Fucoidan is partially hydrolyzed with acid and heat.
  • the partially hydrolyzed fucoidan can also be sulfonated.
  • Other ingredients that can be included in the dietary supplement include antioxidants of high ORAC value, minerals, pepper extract, flavoring agents, coloring agents, and preservatives.
  • the compositions may be in the form of beverages, tablets, capsules, powders, and the like.
  • the present invention provides an anti-aging supplement comprising:
  • Coffee is one of the most popular drinks. Its stimulating effects come from the natural alkaloid: caffeine.
  • Caffeine is the antagonist of adenosine receptors Al and A2. Caffeine acts chronotropically positive and increases the action of the heart; positive inotropic and increases cardiac contraction; Tronotropic (chronotropic) positive and increases the muscle tone of the heart, vascular stenosis of the brain, vasodilation of coronary vessels, renal vessels, muscle vessels and skin vessels.
  • blood pressure does not increase significantly after caffeine consumption.
  • Caffeine reduces oxidative stress due to its ability to induce mRNA and protein expression. In addition, caffeine and its metabolites help in adequate cognitive functionality.
  • the lipid fraction of coffee containing cafestol and kahweol acts as a safeguard against some malignant cells by modulating detoxifying enzymes.
  • Caffeine plays a role in daily glycemic management. Caffeine consumption can reduce the risk of type 2 diabetes mellitus and hypertension, as well as other conditions associated with cardiovascular risk such as obesity and depression. Beneficial effects on cardiovascular adverse risks are suggested, including coronary heart disease, congestive heart failure, arrhythmias, and stroke. Extensive epidemiological studies suggest that regular coffee drinkers have reduced mortality risks. Possible benefits also include protection against neurodegenerative diseases, better asthma control, and a reduced risk of select gastrointestinal diseases. A daily intake of 2 to 3 cups of coffee appears to be safe and is associated with beneficial effects for most of the health outcomes studied.
  • Coffee consumption can regulate the levels of intestinal peptides (glucose-dependent insulinotropic polypeptide and glucagon-1-like peptide) hormones intimately involved in satiety regulation and insulin secretion.
  • Caffeine can have similar prebiotic properties, altering the intestinal flora and ultimately, digestion.
  • Blueberries can improve the selected characteristics of the metabolic syndrome and those related to cardiovascular risk factors.
  • Antioxidants and changes in cell membrane potential signaling are the main driving forces that transfer signals through the cell membrane to the cytosol and nucleus, triggering gene expression, changes in cell proliferation and induction of apoptosis. or DNA repair. Cranberries have been shown to have a protective effect against cardiovascular disease; as well as possessing the ability to inhibit cervical cells, and modulate the postprandial glucose and insulin response.
  • Berry phenols are powerful antioxidants; The antioxidant activity of phenolic compounds, in addition to other mechanisms, can contribute to human health. Studies conducted to date have shown that berries can have a beneficial effect in reducing LDL oxidation, as well as a favorable effect on endothelial health and blood pressure.
  • Blueberries were shown to reduce the formation of PGA (advanced glycation end products), in a concentration-dependent manner, positively correlated with the total phenolic content and the total anthocyanin content.
  • the main functions of blueberries within the anti-aging supplement are:
  • Ursolic acid modulates multiple objectives, including transcription factors, growth factors, tumor cell survival factors, inflammatory pathways, and invasion and angiogenesis closely linked to colon cancer.
  • Ursolic acid (as well as some other related compounds) is capable of inducing PTEN (a tumor suppressor mutation which is frequently discovered in human tumors including type of endometrial cancer I) and the amount / activity of brown fat. Ursolic acid has recently been proposed as a potential candidate for the treatment of muscle loss.
  • Ursolic acid a natural pentacyclic triterpenoid carboxylic acid, is the main component of some herbs in traditional medicine and is well known for possessing a wide range of biological functions, such as antioxidant, anti-inflammation, and anti-cancer activities, which They are capable of counteracting endogenous and exogenous biological stimuli.
  • Ursolic acid has shown immunomodulatory and antitumor activities. It was found to inhibit metastatic progression and tumor-induced angiogenesis. Ursolic acid may be useful in the treatment of IBD (Inflammatory Bowel Disease) as a nutritional supplement. Ursolic acid has been shown to be key to multiple pro-inflammatory transcription factors, cell cycle proteins, growth factors, kinases, cytokines, chemokines, adhesion molecules and inflammatory enzymes.
  • Ursolic acid is currently in a clinical trial in humans for the treatment of cancer, tumor wrinkles, and skin. Ursolic acid can be considered as a powerful therapeutic agent in the treatment of ND (diabetic nephropathy).
  • ursolic acid within the anti-aging supplement are:
  • Turmeric oil present in turmeric, can improve the bioavailability of curcumin;
  • Curcumin has proven effective in mediating the free radical inhibitory effects, the increase in antioxidants, which influence multiple signaling pathways, especially kinases (MAPK, ERK), myeloperoxidase inhibition, COX- 1, COX-2, LOX, TNF-a, IFN- ⁇ , iNOS; NF-kB transcription factor inhibition, therefore decreasing inflammatory bowel disease (IBD), which comprises colitis Ulcerative (UC) and Crohn's disease (CD) is an important disease that affects the small and large intestine.
  • IBD inflammatory bowel disease
  • UC colitis Ulcerative
  • CD Crohn's disease
  • Curcumin has many important bioactivities such as antioxidant activity, induction of cell apoptosis, inhibition of cell proliferation, anti-cell adhesion and motility, anti-angiogenesis and anti-microbial properties.
  • turmeric has proven effective against numerous human diseases, including lupus nephritis, cancer, diabetes, irritable bowel syndrome, acne, and fibrosis.
  • Curcumin strongly inhibited collagenase and stromelysin expression in micromolar concentrations, while quercetin did not. Turmeric is presented as a new promise, adjuvant or natural antidepressant.
  • curcumin The anti-inflammatory effect of curcumin is probably mediated through its ability to inhibit cyclooxygenase-2 (COX-2), lipoxygenase (LOX), and inducible nitric oxide synthase (iNOS).
  • COX-2 cyclooxygenase-2
  • LOX lipoxygenase
  • iNOS inducible nitric oxide synthase
  • turmeric The main functions of turmeric in an anti-aging supplement are:
  • citrulline may be an important adjuvant in the treatment of patients with stable and stable systolic heart failure.
  • Supplementation with L-citrulline has proven to be safe and psychologically well accepted. Findings suggest that short-term L-citrulline supplementation may functionally improve arterial stiffness, regardless of blood pressure, in humans
  • L-citrulline can be a viable adjuvant treatment to decrease the responses of Arterial Pressure and Aix (puslo-flexion wave responses) induced by cold.
  • Supplementation with L-citrulline malate can improve the use of amino acids, especially branched-chain amino acids during exercise and also improve the production of arginine-derived metabolites such as nitrite, creatinine, ornithine and urea.
  • Watermelon supplementation improves aortic hemodynamics through a decrease in the amplitude of the reflected wave in individuals with pre-hypertension; It also reduces arterial and aortic stiffness (arterial systolic pressure) by reducing the pressure wave Vietnamese in postmenopausal obese women with hypertension
  • citrulline within the anti-aging supplement are:
  • Chia (Salvia hispanica L) is a herbaceous plant of the family of lamiaceae; It is native to central and southern Mexico, Guatemala and Guatemala and, together with flax (Linum usitatissimum), is one of the plant species with the highest concentration of omega 3 alpha-linolenic fatty acid known until 2006. It is therefore cultivated for Take advantage of its seeds, which are used ground as food.
  • Chia seed contains about 38% carbohydrates; Of these, 30.5% is insoluble fiber, 3.1% is soluble fiber and the rest are starches. In an aqueous medium, the seed is wrapped in a copious mucilaginous polysaccharide. When a spoonful of chia is mixed with water and put to rest for a few minutes, a solid gel will form; Such a reaction is due to the soluble fiber of the seed. Some researchers assume that such a phenomenon also occurs in the stomach when foods containing these types of gums are ingested. The gel formed in the stomach becomes a physical barrier for the rapid enzymatic digestion of some carbohydrates, preventing their transformation into simple sugars and modulating the metabolism of these compounds for the benefit, for example, of diabetics. On the other hand, the dietary fiber of chia has a favorable effect during the transport of the fecal bolus, thus preventing obesity and various diseases of the digestive tract.
  • hydrophilic properties of the soluble fiber of the chia seed which allow the seed to absorb water up to twelve times its own weight, allow, once consumed, the organism prolongs its hydration state, retains moisture and regulates more efficiently the body fluids, nutrient absorption and, consequently, electrolyte balance.
  • chia (Salvia hispanica L) within the anti-aging supplement are: - Provide Omega 3, fiber, calcium, potassium, magnesium, iron, zinc and copper.
  • the chia that is used is preferably powdered.
  • Bone mass can be significantly increased in postmenopausal women with osteopenia by increasing their daily alkaline intake as Citrate, and the effect is independent of the reported skeletal effects of potassium. Results suggest that treatment with an alkaline salt, such as Potassium Citrate, may reduce bone resorption in contrast to possible adverse effects caused by chronic acidosis caused by protein-rich diets.
  • an alkaline salt such as Potassium Citrate
  • Potassium Citrate has the potential to improve skeletal health.
  • the main functions of Potassium within the anti-aging supplement are:
  • vitamin D has been discovered for immune intervention and how the vitamin D route is used for anti-infectious and antineoplastic immunity. This provides the rationale for new therapeutic strategies in the context of both the prevention and treatment of immune dysregulation in type 1 diabetes.
  • obesity is strongly associated with the deficient state of vitamin D.
  • Supplementation with vitamin D (800 ÜI / d) in combination with calcium can reduce the incidence of fractures by 20%.
  • VDR vitamin D receptor
  • Vitamin D and calcium metabolism are complex and interrelated, and at the same time very controlled through feedback loops established to preserve calcium homeostasis.
  • vitamin D supplements can stabilize Parkinson's disease for a short period in patients with Fokl TT or CT genotypes, without causing hypercalcemia.
  • vitamin D has a crucial role in proliferation, differentiation, neurotropism, neuroprotection, neurotransmission, and neuroplasticity, since it influences cell processes directly through gene expression.
  • Vitamin D is recognized for extra-skeletal actions, in addition to its classic roles in bone and mineral homeostasis. Vitamin D hydroxylases play an important role in the pathogenesis of cancer and crosstalk between the extra-renal / paracrine autocrine vitamin D system and calcium in cancer prevention.
  • Vitamin D status protects against Parkinson's disease.
  • Vitamin D deficiency in adults can cause osteomalacia, increase the risk of fractures in osteoporosis, induce cardiovascular disease, type 1 and 2 diabetes, multiple sclerosis, cancer, including colon, breast and prostate cancer.
  • Vitamins D within the anti-aging supplement are:
  • Glucocorticoid-induced osteoporosis can be prevented by administering the minimum effective dose of glucocorticoids, supplementation with calcium and vitamin D.
  • Vitamin D deficiency and low calcium intake are considered risk factors for several types of cancer.
  • the main functions of Calcium within the anti-aging supplement are:
  • the proteins involved in zinc homeostasis can be altered in aging; This phenomenon can lead to Zinc deficiency in the peripheral blood and an accumulation of Zinc together with insoluble aggregates at the extracellular level in the brain, therefore, it should be more correct to speak of aging as a condition associated with des-homeostasis of the zinc instead of deficiency. Restoring functional zinc homeostasis in the elderly is a field for anti-aging.
  • Zinc dysfunctional signaling is involved in disease processes, including cardiovascular disease, Alzheimer's disease and diabetes.
  • antioxidants improves both nervous and immune functions, decreasing their oxidative stress, and consequently there is a significant increase in longevity.
  • Zinc within the anti-aging supplement are: - Cellular DNA damage repair
  • a combination of malnutrition and nutritional deprivation of Sulfur maximizes the risk of cardiovascular diseases and strokes, which constitutes a new clinical entity that threatens population groups that eat plants.
  • the biogenesis of the Fe / S protein (Iron / Sulfur) and the cellular metabolism of Iron are closely linked to coordinate the supply and use of Iron.
  • Sulfur can have clinical applications in the treatment of a number of conditions such as depression, fibromyalgia, arthritis, interstitial cystitis, athletic injuries, congestive heart failure, diabetes, cancer and AIDS.
  • the main functions of sulfur within the anti-aging supplement are:
  • Magnesium supplementation has been shown to be beneficial in the treatment of, among others, preeclampsia, migraine, depression, coronary artery disease, and asthma.
  • magnesium can promote the spread of cortical depression, platelet hyperaggregation, affect serotonin receptor function, and influence the synthesis and release of a variety of neurotransmitters.
  • Magnesium is necessary for Thiamine and Magnesium-dependent transketolase, as it appears twice in the oxidative pathway of pentoses, important in the production of reduction equivalents. Magnesium plays a regulatory role in normal and neoplastic cells.
  • Free Magnesium is the main regulator of glycolysis and the Krebs cycle. It also acts as a second messenger for growth factors in the regulation of protein synthesis. Magnesium deficiency can cause a wide variety of features including hypocalcemia, hypokalemia, heart and neurological conditions. The decreased chronic state of Magnesium has been associated with a number of chronic diseases, such as diabetes, hypertension, coronary heart disease, and osteoporosis.
  • the main functions of magnesium within the anti-aging supplement are:
  • Coenzyme Q10 is a potent antioxidant to protect against LDL oxidation and may be a good alternative to reduce the risk of atherosclerosis and coronary heart disease and other associated free radical health problems.
  • Coenzyme Q10 is now used as a nutritional supplement due to its antioxidant properties and is beneficial in the treatment of various human diseases when administered orally.
  • Coenzyme Q10 like most flavin-dependent enzymes, catalyzes oxidation-reduction processes in primary metabolic pathways such as the citric acid cycle, ⁇ -oxidation and amino acid degradation.
  • Coenzyme Q10 is a key component for bioenergetics and antioxidant protection in the cell.
  • diseases related to Coenzyme Q10 deficiency has highlighted the essential role of lipid or cell physiology. It is important to take into account that CoQlO levels are also affected during aging and neurodegenerative diseases. Studies show that mitochondrial DNA depletion syndromes are frequently associated with CoQlO deficiency.
  • Coenzyme Q10 ubiquinol, Q (10) H (2)
  • Dietary supplementation with coenzyme Q10 is a key component of the electron transport chain and a powerful antioxidant, rescued many of the harmful effects of nutritional programming on cardiac aging.
  • Early recognition of Coenzyme Q10 deficiency is essential to establish adequate and timely treatment, thus avoiding irreversible tissue damage.
  • Hesperidin protects cortical cells from primary cultures against oxidative neuronal damage induced by H2O2 or xanthine and xanthine oxidase.
  • flavonoids hesperidin is found mostly in tangerine and sweet orange.
  • the physiological broth of citrus fruits has good potential as sources of different bioactive compounds and antioxidants.
  • isothiocyanates can suppress tumor growth by blocking enzymes.
  • blocking agents are the idols and isothiocyanates (ITCs) of cruciferous plants which prevent carcinogens from damaging cell targets, such as DNA, RNA and proteins, since they have the ability to block metabolic activation of carcinogens through the inhibition of the activity of Phase I enzymes.
  • ITCs isothiocyanates
  • Suppressing agents such as isothiocyanates prevent the development of the tumor and its mechanisms of action are: blockage of the cell cycle, modulation of the apoptotic process (they can have a dual effect, that is, induce or inhibit cell death by apoptosis, depending on the dose administered) and inhibition of cell signaling pathways that are stimulated in tumor cells.
  • Isothiocyanates suppress tumor growth by generating reactive oxygen species or by inducing the arrest of the cycle that leads to apoptosis.
  • Isothiocyanates In mammalian tissues, sub-toxic concentrations of isothiocyanates can provide protective effects against cancer and other diseases partially by induction of glutathione transferases (GSTs) and other detoxification enzymes. Isothiocyanates have a biphasic effect on cell growth and migration. The benefits and risks of isothiocyanates are not only determined by doses, but also affected by interactions with selenium.
  • GST glutathione S-transferase
  • isothiocyanates may have an even wider relevance to cancer, since they can directly modulate the activity of a number of protein targets, including other redox enzymes in the pathways and in signaling networks of cell division and cell cycle control.
  • folic acid, vitamin B12, choline, zinc, selenium, dietary polyphenols such as isothiocyanates are able to interact with epigenetic mechanisms and ultimately gene expression.
  • Hydroxyphenolic compounds such as isothiocyanates have the potential to improve cardiovascular problems related to aging such as hypertension, atherosclerosis and dyslipidemia. Results suggest that high levels of isothiocyanate exposure in the diet could reduce the risk of pancreatic cancer. Epidemiological evidence suggests a strong inverse relationship between the nutritional intake of cruciferous vegetables and the incidence of cancer.
  • Isothiocyanates have been extensively studied in experimental in vitro and in vivo carcinogenesis models for their chemopreventive properties of cancer.
  • the main functions of isothiocyanates within the anti-aging supplement are:
  • Anthocyanins are natural polyphenols studied extensively in decades and that over time have been refined both obtaining and extraction, as well as being obtained by total or semi-total synthesis
  • Phytochemicals derived from natural products are preventive chemo agents, which include capsaicin, trans-anetole, thymoquinone, diosgenin, allicin and can not only reduce the risk of acquiring a specific cancer but also suppress the proliferation of cancer cells, as well as the inhibition of growth factor pathways and those of nuclear factor- ⁇ , AP-1, Akt, MAPK, Wnt, Notch, p53, AR, ER, and JAK-STAT, in addition to inducing apoptosis
  • ellagic acid within the anti-aging supplement are:
  • Anthocyanins are water-soluble pigments that are found in the vacuoles of plant cells and that give the leaves, flowers and fruits red, purple or blue color.1 From a chemical point of view, anthocyanins belong to the group of flavonoids and they are glycosides of anthocyanidins, that is, they are constituted by a molecule of anthocyanidin, which is aglycone, to which sugar is attached through a glucosidic bond. Its functions in plants are multiple, from the protection of ultraviolet radiation to the attraction of pollinating insects.
  • anthocyanins are potential agents in obtaining products with added value for human consumption. They exert known therapeutic effects that include the reduction of coronary heart disease, anti-tumor, anti-inflammatory and antidiabetic effects, as well as the improvement of visual acuity and cognitive behavior.
  • the therapeutic effects of anthocyanins are related to their antioxidant activity. Studies with anthocyanin fractions from wine have shown that they are effective in trapping reactive oxygen species, as well as inhibiting the oxidation of lipoproteins and platelet aggregation.
  • Anthocyanins in the anti-aging supplement are:
  • Vitamin A and provitamin A protect the activity of lipid per oxidation.
  • Vitamin A and its active metabolite are essential for the development and function of many tissues including the immune system. Induction of mucosal receptors in T and B cells by mucosal dendritic (DC) cells depends on the presence of vitamin A. Numerous cellular functions, including bone cell functions, and vision are mediated by vitamin A. Retinoic acid, the main active biological form of vitamin A, influences the expression of collagen, laminins, entactin, fibronectin, elastin. and proteoglycans, which are the main components of the extracellular matrix.
  • Retinoic Acid can lead to cytotoxicity, which is probably the most used as a potential supplement in the daily diet of one to prevent or suppress the progression of cancer (in melanoma, hepatoma, lung cancer, breast cancer and prostate cancer).
  • Vitamin A has an important effect on the chronic inflammatory response.
  • a deficiency of vitamin A increases the response of a type T-helper 1 (Thl), increases the levels of pro-inflammatory cytokines, increases the expression of leptin, resistin and decoupling proteins (PCU) and promotes adipogenesis.
  • Thl type T-helper 1
  • PCU resistin and decoupling proteins
  • catechins have an important role in reversing the loss of plasticity and recovery of neuronal lesions associated with aging.
  • the catechins present in green tea have the ability to prevent atherosclerosis, hypertension, endothelial dysfunction, cardiac ischemic diseases, cardiomyopathy, cardiac hypertrophy and congestive heart failure as it reduces oxidative stress, prevents inflammation, reduces platelet aggregation and stops smooth muscle vascular cell proliferation.
  • catechins support an effect by inducing antioxidant enzymes, as well as inhibiting pro-oxidant enzymes and sweeping free radicals. They inhibit the transcriptional factor NF- ⁇ whose production is mediated by cytokines and adhesion molecules.
  • Green tea extract can modulate brain activity in the prefrontal lateral dorsal cortex, which is a key area in the memory process in the human brain.
  • the consumption of green tea catechins has beneficial effects on blood pressure and lipid parameters.
  • the differences in the tone of small blood vessels from the impact of catecholamine O-methyl transferase after ingestion of green tea extract is to improve blood pressure and vascular function.
  • green tea catechins promotes the development of a joint treatment strategy with anticancer drugs to increase their therapeutic potential, in addition to lowering the cytotoxicity and cost of it. They could play an intervention and prevention role in prostate cancer populations that Consume large amounts of green tea usually have the lowest incidence of this type of pathology.
  • Green tea catechins inhibit the proliferation of breast cancer cells and block their carcinogenesis, the proposed mechanisms are: modulation of extracellular signals, induction of apoptosis through redox reduction or through modulation epigenetic alterations.
  • vitamin C helps to develop and maintain collagen, bones, teeth and blood vessels, as well as collaborate in the control of infections, the absorption of iron and is used as a treatment for the state of generalized inflammation in addition to decreasing the systolic and diastolic pressure.
  • Acute administration of vitamin C is able to reduce the cardiovascular adrenergic response of hypertensive patients and suggests that oxidative stress is involved in the regulation of sympathetic activity in essential hypertension. It is concluded that 200 mg per day is the optimal daily intake of vitamin C for the majority of the adult population, which maximizes the potential health benefits, as well as the lower risk of side effects.
  • vitamin C The main functions of vitamin C within the anti-aging supplement are:
  • Astaxanthin improves the activity of superoxide and suppresses the total production of hydroxyperoxides in the human aqueous humor, indicating that astaxanthin has suppressive effects in various diseases related to oxidative stress.
  • Astaxanthin has an unusual antioxidant activity with benefits on the prevention of cardiovascular diseases, the increase of the immune system, bioactivity against helicobacter pylory and prevention of cataracts.
  • Astaxanthin inhibits the oxidation of low density lipoproteins, which probably contributes to the prevention of atherosclerosis.
  • Astaxanthin, as well as omega 3 fatty acids individually or in combination protect against oxidative stress.
  • Astaxanthin protects the mitochondria against endogenous oxygen radicals, preserving its antioxidant capacity (redox) and improving efficiency in energy production, in addition to its effects can go beyond protection against oxidative stress and inflammation
  • Astaxanthin within the anti-aging supplement are:
  • Resveratrol is useful in therapy on endothelial growth factor (VEGF) as it acts on age-related macular degeneration. Resveratrol attenuates cardiovascular, cerebrovascular, and peripheral vascular risk.
  • VEGF endothelial growth factor
  • Resveratrol a phytoalexin polyphenol, present in red wine and grapes, possesses various biochemical and physiological properties, including estrogenic, anti-platelet activity, and anti-inflammatory properties, as well as a wide range of health benefits ranging from chemo prevention until cardio protection.
  • Neuroprotective effects have been found in neurodegeneration models (Alzheimer's, Parkinson's or Huntington's disease, or various neuropathies), ischemia and brain and spinal cord injuries thanks to the use of Resveratrol.
  • Resveratrol is a potent antioxidant and an anti-inflammatory agent. Reduces the expression of adhesion molecules cell, monocyte colony stimulation factors, matrix metalloproteinases, and growth factors; and inhibits platelet aggregation and proliferation of vascular smooth muscle cells. It reduces serum levels of total cholesterol, triglycerides (TG) and increases high-density lipoprotein cholesterol, inhibits the expression of C-reactive protein and decreases levels of advanced glycation end products and its receptor in vascular tissue. Risk factors for plaque rupture are reduced.
  • TG triglycerides
  • resveratrol reduces myocardial damage during ischemic perfusion, modulation of vascular cellular functions, inhibition of LDL oxidation, and suppression of platelet aggregation. Resveratrol was associated with beneficial changes in blood lipid profiles, fasting blood glucose and heart rate, suggesting that consumption of resveratrol decreases cardiovascular risk factors (CV).
  • CV cardiovascular risk factors
  • resveratrol within the anti-aging supplement are:
  • Boron supplementation does not adversely affect Magnesium. However, its depletion causes changes similar to those presented by women in the menopause stage in relation to osteoporosis. These elements are necessary for optimal calcium metabolism and prevent excessive bone loss that frequently occurs in postmenopausal women and older men.
  • isoflavones should be considered a potent anti-cancer therapeutic agent.
  • Soy isoflavones are moderately effective in relieving symptoms of menopause, and are also associated with a lower risk of breast and endometrial cancer.
  • Soy isoflavones show mild and slow but positive effects in reducing hot flashes in menopause, compared to estradiol.
  • Soy isoflavone supplementation seems to have a positive effect on improving cognitive function and visual memory in post menopausal women. Including soy foods in the diet helps improve the health of post-menopausal women.
  • isoflavones are di-phenolic compounds that have various functions in cell mechanisms: they generally form a phenotype of inert cells in some types of cancers and also improve connective tissue in the cell anchor through the effects on proteins In the extracellular matrix, they also affect the integrity of the cytoskeleton, as well as the effects related to the flow and involvement of calcium ions for the retraction, differentiation or proliferation, which involve mechanical states.
  • endo / exocitosisy are functional morpho defining of cell mechanics.
  • the main functions of Isoflavones within the anti-aging supplement are mainly for women:
  • the concentration of the components of the anti-aging supplement are:
  • the anti-aging supplement of the present invention can vary the formulation of the components and their concentration in 4 supplements:
  • the concentration of the components of the morning anti-aging supplement for men is:
  • the concentration of the components of the morning anti-aging supplement for women is:
  • the concentration of the components of the evening anti-aging supplement for men is:
  • the concentration of the components of the evening anti-aging supplement for women is:
  • the anti-aging supplement may be in usual forms, such as solution, suspension, emulsion, powder, tablet, capsule, solid, liquid or ointment.
  • Example 1 Preparation of 1,000 grams of the anti-aging supplement for the taking of men in the morning, reason for the present invention.
  • Example 3 Preparation of 1,000 grams of the anti-aging supplement for the taking of men in the afternoon, reason for the present invention.
  • Example 4 Preparation of 1,000 grams of the anti-aging supplement for taking women in the afternoon, reason for the present invention.
  • the components are mixed with the following amounts:

Abstract

La présente invention concerne le domaine technique de la nutrition, de la technologie des aliments et de la médecine et porte sur un complément anti-âge qui vise à améliorer la santé et à ressentir plus de vitalité. Le complément anti-âge présente l'avantage, à une concentration déterminée des constituants dudit complément, de pouvoir être profitable spécifiquement à l'homme, le matin, le midi ou le soir; et si on passe à une concentration déterminée, il sera bénéfique pour les femmes le matin, le midi ou le soir. Ce qui précède résulte du fait que les besoins dépendent du genre et du biorythme (cycle biologique) du corps humain.
PCT/MX2016/000019 2016-02-23 2016-02-23 Complément anti-âge WO2017146560A1 (fr)

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MX2016002359A MX2016002359A (es) 2016-02-23 2016-02-23 Suplemento antienvejecimiento.
MXMX/A/2016/002359 2016-02-23

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WO2017146560A1 true WO2017146560A1 (fr) 2017-08-31

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EP3496844A4 (fr) * 2016-08-15 2020-03-18 Summit Innovation Labs, LLC Calcification vasculaire et prévention et traitement de maladies cardiovasculaires/associées
EP3512486B1 (fr) 2016-09-16 2020-10-21 L'Oreal Poudre bleue et son utilisation en cosmétique

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3496844A4 (fr) * 2016-08-15 2020-03-18 Summit Innovation Labs, LLC Calcification vasculaire et prévention et traitement de maladies cardiovasculaires/associées
EP3512486B1 (fr) 2016-09-16 2020-10-21 L'Oreal Poudre bleue et son utilisation en cosmétique

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