WO2017146560A1

WO2017146560A1 - Anti-aging supplement

Info

Publication number: WO2017146560A1
Application number: PCT/MX2016/000019
Authority: WO
Inventors: Francisco Elías ARROYO PAZ
Original assignee: Arroyo Paz Francisco Elías
Priority date: 2016-02-23
Filing date: 2016-02-23
Publication date: 2017-08-31
Also published as: MX2016002359A

Abstract

The invention relates to the technical field of nutrition, food technology and medicine, given that it provides an anti-aging supplement for promoting improved health and a feeling of vitality. The benefit of the anti-aging supplement is that, with a determined concentration of the components of said supplement, same can be used specifically by men in the morning, the afternoon or at night; and if this is changed to another determined concentration, the benefit would be for women in the morning, the afternoon or at night. This is due to the fact that the requirements depend on the gender and biorhythm (biological cycle) of the human body.

Description

ANTI-AGING SUPPLEMENT

TECHNICAL FIELD OF THE INVENTION The present invention relates to the technical field of nutrition, food technology and medicine; since it provides an anti-aging supplement.

BACKGROUND OF THE INVENTION

In order to be able to prolong the life of patients, improve their quality and control, delay and even prevent the loss of physical, mental and, consequently, the development of age-related diseases, a new branch of medicine appears : is the medicine Antiaging or anti-aging.

Anti-aging medicine is a clinical-medical specialty in the field of scientific research aimed at early detection, prevention, treatment and reversal of age. It is well documented by medical and scientific journals and employs evidence-based methodologies to carry out patient evaluations.

Anti-aging medicine is aimed at all people, regardless of their age, who want to improve their health, their quality of life. It is recommended for all those over 35 years of age, as prevention of aging processes and the pathologies that accompany them, regardless of whether anyone can perform a revitalization program, since all programs are fully individualized. For the scientific community, anti-aging refers exclusively to lessen, prevent, or reverse the aging process. The above is very different from the fight against the aging process itself and for this, if there is a wide range of strategies and therapies that are used today. Calorie restriction and physical activity, for example, are some of the ways shown to reduce the risk of suffering from many age-related degenerative conditions.

In general terms, the definitions of anti-aging include as meaning the fact of looking and feeling more vital, that is, it is not related to the time you live or how healthy you are going to be.

A state-of-the-art search on supplements and anti-aging supplements was carried out and the patent application number US2004001817 (Al) was found, with publication date January 1, 2004 entitled "Nutritional Supplement for Aging" describes a composition of Anti-aging nutritional supplement includes vitamins, minerals, an inflammatory support process, blood sugar / insulin, a botanical antioxidants, a methylation factor, a DNA repair agent, a fat metabolizer, an absorption promoter, a support of brain function, whole foods, a cellular energizer, a precursor of nucleotides, amino acids, a complex of fatty acids and digestive enzymes. The composition provides nutritional supplements necessary for proper glycation, DNA methylation, anti-oxidation, and control of inflammatory processes The composition and method of use provide an effective treatment against aging by decreasing DNA damage, increasing DNA repair, and improving the immune function of the human body.

Another document is the granted patent number US8568804 (B2), in which a composition for use as an antioxidant is disclosed, such as for use as an anti-aging supplement. The composition may include muscadine (Vitis rotundifolia), pomace extract having a content of at least 2% polyphenols and trans-resveratrol from a source other than muscadine with a minimum purity of at least 5%. Production methods of antioxidant compositions are also described. These methods may include the combination of a muscadine pomace extract having a polyphenol content of at least 2% and resveratrol from a source other than muscadine with a minimum purity of at least 5% at a ratio in the range of 0 , 1/1 to 10/1 (weight to weight), thereby providing a composition with antioxidant activity.

The third document is patent application US2004770953 (A) with the title "Anti-Aging Supplement for Pet Welfare", which describes a nutritional supplement for pets, particularly canine pets, which consist essentially of antioxidant vitamins, vitamins of the B complex, bioflavonoids, chelated minerals, digestive enzymes, herbs, nutrients and essential fatty acids, amino acids and hormones. One more document is the patent application GB20130014247 (A), said document has the title of "Dietary supplement in bar" and describes a bar as a nutritional dietary supplement that functions as an anti-aging comprising the following substances: one or more antioxidants, one or more more plants or plant derivatives that stimulate the endocrine system with anti-aging function and one or more organic oils as a source of at least omega 3, omega 6 and omega 9. The antioxidant is preferably turmeric, fermented papaya, resveratrol, astaxanthin, green tea, ginkgo, selenium, vitamin C and E. Plants or plant derivatives that stimulate the endocrine system with anti-aging function are maca, damiana, red clover, wild yam, black cohosh, soybeans, sage, ginseng, blueberries, oats, fenugreek, tribulus, taurine, guarana and saw palmetto. Vitamins, amino acids, and fish of collagen or hyaluronic acid can also be added.

Another document is patent application number US20100323984 (A3), which describes a cosmetic oral and / or parenteral use of glucosamine as an active ingredient to prevent and / or treat skin signs of aging, optionally in combination with at least one compound of polyphenol The application in question also refers to a composition for oral and / or parenteral administration comprising, as an active ingredient, the combination of glucosamine and at least one polyphenol compound derived from pine bark.

The document of the patent application ÜS20060307029 (Al) entitled "Solid dosage form to provide a dietary supplement" was also found in said Compositions and methods related to partially hydrolyzed fucoidan are described for use in dietary supplements. Fucoidan brown seaweed is partially hydrolyzed and then mixed with other ingredients for use as a dietary supplement in beverage, capsule, or tablet form. Fucoidan is partially hydrolyzed with acid and heat. The partially hydrolyzed fucoidan can also be sulfonated. Other ingredients that can be included in the dietary supplement include antioxidants of high ORAC value, minerals, pepper extract, flavoring agents, coloring agents, and preservatives. The compositions may be in the form of beverages, tablets, capsules, powders, and the like.

Finally we have the patent application US19970898090

(Al) with the title "Metabolic auxiliary and cell repair method", which describes a multi-agent

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edible of vitamins, minerals, plant extracts, amino acids, neurochemical precursors, enzymes, and agents with Ph that provide key elements necessary for the metabolism and function of the human body delivered at specific times of the daily biocycle, when regulating there is a need for such agents specific in order to maximize the extra and intra-cellular matrix of the body to the cellular and biochemical protection and repair mechanisms used to deter the effects of otherwise normal aging. As can be seen in the previous documents, it is that although it is true there are several products that help with anti aging, not a single document shows that, with a certain concentration, the supplement can be used specifically by man and if it changes to Another concentration determined the benefit would be for women.

OBJECT DB THE INVENTION

It is therefore the object of the present invention, to provide an anti-aging supplement, with the aim of promoting better health and feeling vital.

DETAILED DESCRIPTION OF THE INVENTION

The present invention provides an anti-aging supplement comprising:

- Caffeine

- Blueberries

- ürsolic acid

- Turmeric

- Citrulline

- Chia

- Potassium

- Vitamin D

- Calcium

- Zinc

- Sulfur

- Magnesium

- Coenzyme Q10 (übiquinone)

- Hesperidine

- Isothiocyanates

- Allicin

- Ellagic Acid

- Anthocyanates

- Vitamin A

- Catechins and Polyphenols (Green Tea) - Vitamin C

- Astaxanthin

- Resveratrol

- Boron

- Soy Isoflavones

CAFFEINE

Coffee is one of the most popular drinks. Its stimulating effects come from the natural alkaloid: caffeine. Caffeine is the antagonist of adenosine receptors Al and A2. Caffeine acts chronotropically positive and increases the action of the heart; positive inotropic and increases cardiac contraction; Tronotropic (chronotropic) positive and increases the muscle tone of the heart, vascular stenosis of the brain, vasodilation of coronary vessels, renal vessels, muscle vessels and skin vessels. However, in healthy subjects, blood pressure does not increase significantly after caffeine consumption.

Caffeine reduces oxidative stress due to its ability to induce mRNA and protein expression. In addition, caffeine and its metabolites help in adequate cognitive functionality. The lipid fraction of coffee containing cafestol and kahweol acts as a safeguard against some malignant cells by modulating detoxifying enzymes.

In women, the relationship between caffeine and the risk of Parkinson's disease resulted in the lowest risk observed in moderate intakes (1-3 cups of coffee / day). These results support a possible protective effect of moderate doses of caffeine on the risk of Parkinson's disease. Results from a representative sample of adults suggest that coffee consumption is associated with a lower serum uric acid level and frequency of hyperuricemia, compared to tea.

Study provides empirical support for recommendations on sleep hygiene: to refrain from substantial use of caffeine for a minimum of 6 hours before bedtime. Differences in plasma glucose, insulin, and gastrointestinal hormone profiles confirm the potent biological action of caffeine, suggesting that chlorogenic acid could have an antagonistic effect on glucose transport. This new function of some dietary phenols in humans could be the decrease in the intestinal glucose absorption rate and change the site of glucose absorption to the most distal parts of the intestine.

It was found that the consumption of 4 cups or more of coffee per day showed a preventive effect on stroke. Results suggest that coffee consumption is inversely related to markers of inflammation and endothelial dysfunction.

Ingestion of coffee (with caffeine) after a meal resulted in decreased insulin sensitivity in the postprandial phase of a second meal in the absence of a caffeine intake. Caffeine plays a role in daily glycemic management. Caffeine consumption can reduce the risk of type 2 diabetes mellitus and hypertension, as well as other conditions associated with cardiovascular risk such as obesity and depression. Beneficial effects on cardiovascular adverse risks are suggested, including coronary heart disease, congestive heart failure, arrhythmias, and stroke. Extensive epidemiological studies suggest that regular coffee drinkers have reduced mortality risks. Possible benefits also include protection against neurodegenerative diseases, better asthma control, and a reduced risk of select gastrointestinal diseases. A daily intake of 2 to 3 cups of coffee appears to be safe and is associated with beneficial effects for most of the health outcomes studied.

Compared to non-coffee drinkers, coffee drinkers who consume 4-5 cups a day and greater than or equal to 6 cups of coffee a day, have a lower risk of colon cancer, particularly of proximal tumors.

Coffee consumption can regulate the levels of intestinal peptides (glucose-dependent insulinotropic polypeptide and glucagon-1-like peptide) hormones intimately involved in satiety regulation and insulin secretion. Caffeine can have similar prebiotic properties, altering the intestinal flora and ultimately, digestion.

Regular coffee consumption is associated with a lower risk of type 2 diabetes. Those who drink 4 to 6 cups and more than 6-7 cups of coffee a day have a lower risk of type 2 diabetes compared to those who drink less than 2 cups per day Epidemiological studies do not provide enough evidence to support an association between coffee and tea consumption and the risk of ovarian cancer.

Long-term coffee consumption is not associated with an increased risk of stroke in women. For him On the contrary, the data suggest that coffee consumption can modestly reduce the risk of stroke. The main functions of caffeine within the anti-aging supplement are:

- stimulate the central nervous system in the short term.

- Reduce the risk of dementia, Alzheimer's, Parkinson's.

- Regulate glucose metabolism. Blueberries

Blueberries can improve the selected characteristics of the metabolic syndrome and those related to cardiovascular risk factors.

Recent studies demonstrated the benefit of blueberries to prevent age-related chronic diseases such as cancer, diabetes, hyperlipidemia, hypertension, neurodegeneration, obesity and osteoporosis through its effects of apoptosis, antioxidant, anti-inflammatory and anti-angiogenesis. Blueberries can eradicate microorganisms for the prevention of urinary tract infections in symptomatic women.

Antioxidants and changes in cell membrane potential signaling are the main driving forces that transfer signals through the cell membrane to the cytosol and nucleus, triggering gene expression, changes in cell proliferation and induction of apoptosis. or DNA repair. Cranberries have been shown to have a protective effect against cardiovascular disease; as well as possessing the ability to inhibit cervical cells, and modulate the postprandial glucose and insulin response.

Berry phenols are powerful antioxidants; The antioxidant activity of phenolic compounds, in addition to other mechanisms, can contribute to human health. Studies conducted to date have shown that berries can have a beneficial effect in reducing LDL oxidation, as well as a favorable effect on endothelial health and blood pressure.

Blueberries were shown to reduce the formation of PGA (advanced glycation end products), in a concentration-dependent manner, positively correlated with the total phenolic content and the total anthocyanin content.

The main functions of blueberries within the anti-aging supplement are:

- collaborates in the differentiation of adipocytes.

- Induce lipolysis.

URSÓLZCO ACID

Ursolic acid modulates multiple objectives, including transcription factors, growth factors, tumor cell survival factors, inflammatory pathways, and invasion and angiogenesis closely linked to colon cancer.

The active substance identified in ursolic acid, and modulated molecular pathways can be the basis for the way in which these dietary agents not only prevent, but also treat cancer and other diseases. Ursolic acid (as well as some other related compounds) is capable of inducing PTEN (a tumor suppressor mutation which is frequently discovered in human tumors including type of endometrial cancer I) and the amount / activity of brown fat. Ursolic acid has recently been proposed as a potential candidate for the treatment of muscle loss. Ursolic acid, a natural pentacyclic triterpenoid carboxylic acid, is the main component of some herbs in traditional medicine and is well known for possessing a wide range of biological functions, such as antioxidant, anti-inflammation, and anti-cancer activities, which They are capable of counteracting endogenous and exogenous biological stimuli.

Ursolic acid has shown immunomodulatory and antitumor activities. It was found to inhibit metastatic progression and tumor-induced angiogenesis. Ursolic acid may be useful in the treatment of IBD (Inflammatory Bowel Disease) as a nutritional supplement. Ursolic acid has been shown to be key to multiple pro-inflammatory transcription factors, cell cycle proteins, growth factors, kinases, cytokines, chemokines, adhesion molecules and inflammatory enzymes.

Ursolic acid is currently in a clinical trial in humans for the treatment of cancer, tumor wrinkles, and skin. Ursolic acid can be considered as a powerful therapeutic agent in the treatment of ND (diabetic nephropathy).

The main functions of ursolic acid within the anti-aging supplement are:

- Increase muscle mass and strength.

TURMERIC

Turmeric oil, present in turmeric, can improve the bioavailability of curcumin; The components of turmeric-curcumin free (CFT) possess numerous biological activities including anti-inflammatory, anticancer, and antidiabetic effects. It was confirmed that curcuminoids have anti-inflammatory properties in HUVEC (umbilical cord endothelial cells).

Preclinical studies on turmeric point to mechanisms of action that are predominantly anti-inflammatory and antineoplastic, while early human clinical trials suggest beneficial effects for dyspepsia, peptic ulcer, inflammatory bowel disease, rheumatoid arthritis, osteoarthritis, uveitis, orbital pseudotumor, and pancreatic cancer

Curcumin has proven effective in mediating the free radical inhibitory effects, the increase in antioxidants, which influence multiple signaling pathways, especially kinases (MAPK, ERK), myeloperoxidase inhibition, COX- 1, COX-2, LOX, TNF-a, IFN-γ, iNOS; NF-kB transcription factor inhibition, therefore decreasing inflammatory bowel disease (IBD), which comprises colitis Ulcerative (UC) and Crohn's disease (CD) is an important disease that affects the small and large intestine.

Studies conducted provide evidence of safety and superiority of the treatment of turmeric patients with active RA (rheumatoid arthritis).

Curcumin has many important bioactivities such as antioxidant activity, induction of cell apoptosis, inhibition of cell proliferation, anti-cell adhesion and motility, anti-angiogenesis and anti-microbial properties. In clinical trials, turmeric has proven effective against numerous human diseases, including lupus nephritis, cancer, diabetes, irritable bowel syndrome, acne, and fibrosis. Curcumin strongly inhibited collagenase and stromelysin expression in micromolar concentrations, while quercetin did not. Turmeric is presented as a new promise, adjuvant or natural antidepressant.

The anti-inflammatory effect of curcumin is probably mediated through its ability to inhibit cyclooxygenase-2 (COX-2), lipoxygenase (LOX), and inducible nitric oxide synthase (iNOS).

The main functions of turmeric in an anti-aging supplement are:

- Bone protection.

- Antioxidant

- Provide anti-cancer properties. CITRULINE

Its name is derived from citrullus, a Latin word for watermelon, from which Koga and Odake first isolated it in 1914. A study shows that supplementation with watermelon extract reduces blood pressure in the brachial ankle, and the carotid wave reflected in Obese middle-aged adults with pre-hypertension or hypertension in phase 1 and normal ABI, which may reflect improved arterial function.

Administration with citrulline supplements significantly improved LVEF (left ventricular ejection fraction), endothelial function (MAT / index TT) and functional class. Citrulline may be an important adjuvant in the treatment of patients with stable and stable systolic heart failure. Supplementation with L-citrulline has proven to be safe and psychologically well accepted. Findings suggest that short-term L-citrulline supplementation may functionally improve arterial stiffness, regardless of blood pressure, in humans

L-citrulline can be a viable adjuvant treatment to decrease the responses of Arterial Pressure and Aix (puslo-flexion wave responses) induced by cold.

Supplementation with L-citrulline malate can improve the use of amino acids, especially branched-chain amino acids during exercise and also improve the production of arginine-derived metabolites such as nitrite, creatinine, ornithine and urea. Watermelon supplementation improves aortic hemodynamics through a decrease in the amplitude of the reflected wave in individuals with pre-hypertension; It also reduces arterial and aortic stiffness (arterial systolic pressure) by reducing the pressure wave ..... reflected broadly in postmenopausal obese women with hypertension

The main functions of citrulline within the anti-aging supplement are:

- Improve heart rate.

- Reduce the intensity of muscle pain.

CHÍA (Hispanic Sage L)

Chia (Salvia hispanica L) is a herbaceous plant of the family of lamiaceae; It is native to central and southern Mexico, Guatemala and Nicaragua and, together with flax (Linum usitatissimum), is one of the plant species with the highest concentration of omega 3 alpha-linolenic fatty acid known until 2006. It is therefore cultivated for Take advantage of its seeds, which are used ground as food.

Chia seed contains about 38% carbohydrates; Of these, 30.5% is insoluble fiber, 3.1% is soluble fiber and the rest are starches. In an aqueous medium, the seed is wrapped in a copious mucilaginous polysaccharide. When a spoonful of chia is mixed with water and put to rest for a few minutes, a solid gel will form; Such a reaction is due to the soluble fiber of the seed. Some researchers assume that such a phenomenon also occurs in the stomach when foods containing these types of gums are ingested. The gel formed in the stomach becomes a physical barrier for the rapid enzymatic digestion of some carbohydrates, preventing their transformation into simple sugars and modulating the metabolism of these compounds for the benefit, for example, of diabetics. On the other hand, the dietary fiber of chia has a favorable effect during the transport of the fecal bolus, thus preventing obesity and various diseases of the digestive tract.

These hydrophilic properties of the soluble fiber of the chia seed, which allow the seed to absorb water up to twelve times its own weight, allow, once consumed, the organism prolongs its hydration state, retains moisture and regulates more efficiently the body fluids, nutrient absorption and, consequently, electrolyte balance.

Due to its high levels of proteins, unsaturated fatty acids (omega-3 and omega-6), dietary fiber and folic acid, chia could have special benefits for women.

Ingestion of 25 g / day of chia ground seeds compared to all chia seed or placebo for 10 weeks by overweight women increased ALA plasma (conjugated linoleic acid) and EPA (eicosapentaenoic acid).

Some evidence also suggests possible anticoagulant, antioxidant and antiviral effects of Hispanic sage.

The main functions of chia (Salvia hispanica L) within the anti-aging supplement are: - Provide Omega 3, fiber, calcium, potassium, magnesium, iron, zinc and copper.

- Reduce inflammation. The chia that is used is preferably powdered.

POTASSIUM

The interdependence of Sodium Na (+) and Potassium K (+) in the pathogenesis of hypertension indicates that Sodium restriction and an increase in potassium intake are important strategies for primary prevention and treatment of hypertension and its consequences. cardiovascular; This association may be more pronounced in men than in women.

Changes due to increased potassium intake help to inhibit the formation of CaOx stones.

Long-term potassium citrate improves bone density. There is evidence that the increase in potassium intake does not need to be given in the form of Chloride, to reduce blood pressure.

Increasing the consumption of potassium-rich foods is likely to have the same effect on blood pressure as Potassium Chloride.

Increasing potassium intake to 4.7 g per day predicts lower event rates for cardiovascular disease in the future, with an estimated decrease of 8% to 15% in stroke and coronary heart disease, and 6% to 11 % in myocardial infarction.

Treatment with Potassium Citrate for 24 months resulted in a significant increase in aBMD (area of bone mineral density) and volume of mineral density bone in several sites tested, in addition to improving bone micro architecture. Based on the effect on fracture prediction, an effect on future potassium citrate fractures is possible.

Bone mass can be significantly increased in postmenopausal women with osteopenia by increasing their daily alkaline intake as Citrate, and the effect is independent of the reported skeletal effects of potassium. Results suggest that treatment with an alkaline salt, such as Potassium Citrate, may reduce bone resorption in contrast to possible adverse effects caused by chronic acidosis caused by protein-rich diets.

Easily available, safe and easy to administer orally, Potassium Citrate has the potential to improve skeletal health. The main functions of Potassium within the anti-aging supplement are:

- Balance the body's pH.

- Help muscle contractibility. VITAMIN D

Recently, aspects that underscore the potential of vitamin D have been discovered for immune intervention and how the vitamin D route is used for anti-infectious and antineoplastic immunity. This provides the rationale for new therapeutic strategies in the context of both the prevention and treatment of immune dysregulation in type 1 diabetes. In humans, obesity is strongly associated with the deficient state of vitamin D. Supplementation with vitamin D (800 ÜI / d) in combination with calcium can reduce the incidence of fractures by 20%.

In general, the common practice of taking calcium and vitamin D supplements with possible hip benefits and positive evidence on bone mineral density. The possibility of extra skeletal effects of vitamin D was first observed with the discovery of the vitamin D receptor (VDR) in tissues and cells that are not involved in the maintenance of mineral homeostasis and bone health, including the skin, placenta, pancreas , breast, prostate and colon cancer cells, and activated T cells.

Vitamin D and calcium metabolism are complex and interrelated, and at the same time very controlled through feedback loops established to preserve calcium homeostasis.

The administration of vitamin D supplements can stabilize Parkinson's disease for a short period in patients with Fokl TT or CT genotypes, without causing hypercalcemia. There is convincing evidence that vitamin D has a crucial role in proliferation, differentiation, neurotropism, neuroprotection, neurotransmission, and neuroplasticity, since it influences cell processes directly through gene expression.

Vitamin D is recognized for extra-skeletal actions, in addition to its classic roles in bone and mineral homeostasis. Vitamin D hydroxylases play an important role in the pathogenesis of cancer and crosstalk between the extra-renal / paracrine autocrine vitamin D system and calcium in cancer prevention.

The results are consistent with the idea that vitamin D status protects against Parkinson's disease. Vitamin D deficiency in adults can cause osteomalacia, increase the risk of fractures in osteoporosis, induce cardiovascular disease, type 1 and 2 diabetes, multiple sclerosis, cancer, including colon, breast and prostate cancer.

In women with a history of NSCLC (nonmelanoma skin cancer), the administration of calcium and vitamin D supplements reduces the risk of melanoma, suggesting a possible role of calcium and vitamin D supplements in this high-risk group . In order to correct secondary hyperparathyroidism associated with age and to prevent osteoporotic fractures, a daily dose of 1,000-1,200 mg of calcium and 800 ÜI of vitamin D is recommended in the elderly or in institutions, patients with Established osteoporosis and individuals in glucocorticoids.

The main functions of Vitamins D within the anti-aging supplement are:

- Help with metabolism.

- Cellular protection.

- Improve bone density.

- Decrease the risk of melanoma.

- Decrease Skin Cancer. CALCIUM

Glucocorticoid-induced osteoporosis can be prevented by administering the minimum effective dose of glucocorticoids, supplementation with calcium and vitamin D.

In a follow-up post-trial, the group supplemented with calcium has a residual benefit to the whole body (0.41% above placebo; p = 0.04). Calcium deficiency results in a higher body mass index, increases the risk of insulin resistance, type 2 diabetes and osteoporosis. Calcium regulates the tension of the smooth muscles of blood vessels, limits the activity of neurotransmitters and also decreases the dangerous activity of Sodium Chloride.

In most patients, 500 mg per day is required to achieve a total intake of 1200 mg, or at some 1,000 mg per day. Vitamin D deficiency and low calcium intake are considered risk factors for several types of cancer.

The main functions of Calcium within the anti-aging supplement are:

- Promote bone density.

- Improves muscle function.

- Help with the synthesis of neurotransmitters, neuronal communication.

- Reduce cardiovascular risk.

ZINC

The positive association between the ZnTl and Zipl mRNA, which have reciprocal functions in the transport of Zinc through the plasma membrane, provides the Penetration in the coordinated control of zinc homeostasis in humans.

The associations between inflammatory cytoguins and Zinc transporter and metallothionein gene expression support an interrelation between Zinc homeostasis and inflammation in type 2 DM.

Low concentrations of zinc, vitamins A and E in overweight and obese children were associated with lipids, inflammation and insulin resistance.

The proteins involved in zinc homeostasis can be altered in aging; This phenomenon can lead to Zinc deficiency in the peripheral blood and an accumulation of Zinc together with insoluble aggregates at the extracellular level in the brain, therefore, it should be more correct to speak of aging as a condition associated with des-homeostasis of the zinc instead of deficiency. Restoring functional zinc homeostasis in the elderly is a field for anti-aging.

Zinc dysfunctional signaling is involved in disease processes, including cardiovascular disease, Alzheimer's disease and diabetes.

The administration of antioxidants improves both nervous and immune functions, decreasing their oxidative stress, and consequently there is a significant increase in longevity.

The main functions of Zinc within the anti-aging supplement are: - Cellular DNA damage repair

SULFUR

A combination of malnutrition and nutritional deprivation of Sulfur maximizes the risk of cardiovascular diseases and strokes, which constitutes a new clinical entity that threatens population groups that eat plants. The biogenesis of the Fe / S protein (Iron / Sulfur) and the cellular metabolism of Iron are closely linked to coordinate the supply and use of Iron.

In line with the essential function of mitochondria, genetic mutations in a number of ISC genes (Iron-Sulfur complex) lead to serious neurological, hematological and metabolic diseases.

Sulfur can have clinical applications in the treatment of a number of conditions such as depression, fibromyalgia, arthritis, interstitial cystitis, athletic injuries, congestive heart failure, diabetes, cancer and AIDS. The main functions of sulfur within the anti-aging supplement are:

- Metabolize lipids and carbohydrates.

- Formation of amino acids, and vitamin Bl. MAGNESIUM

Magnesium plays an important physiological role in particular in the brain, heart and skeletal muscles. In addition, Magnesium supplementation has been shown to be beneficial in the treatment of, among others, preeclampsia, migraine, depression, coronary artery disease, and asthma.

Lack of magnesium can promote the spread of cortical depression, platelet hyperaggregation, affect serotonin receptor function, and influence the synthesis and release of a variety of neurotransmitters. Magnesium is necessary for Thiamine and Magnesium-dependent transketolase, as it appears twice in the oxidative pathway of pentoses, important in the production of reduction equivalents. Magnesium plays a regulatory role in normal and neoplastic cells.

Free Magnesium is the main regulator of glycolysis and the Krebs cycle. It also acts as a second messenger for growth factors in the regulation of protein synthesis. Magnesium deficiency can cause a wide variety of features including hypocalcemia, hypokalemia, heart and neurological conditions. The decreased chronic state of Magnesium has been associated with a number of chronic diseases, such as diabetes, hypertension, coronary heart disease, and osteoporosis.

Intake of deficient magnesium (<250 mg / day) and serum magnesium concentrations {≤ 0.75 mmol / 1) have been associated with the concentration of elevated serum C-reactive protein, an indicator of inflammation.

Magnesium plays a critical role in modulating vascular smooth muscle tone, endothelial cell function, and myocardial excitability and is the center to the pathogenesis of several cardiovascular disorders such as hypertension, atherosclerosis, coronary artery disease, congestive heart failure, and cardiac arrhythmias.

Depletion of Magnesium in humans can disturb bone and mineral metabolism and be a risk factor for osteoporosis.

Studies have shown that magnesium deficiency results in bone loss.

The main functions of magnesium within the anti-aging supplement are:

- Metabolism of fats, carbohydrates, proteins. - Bone formation.

COENZIMA Q10 (UBIQUINONA)

Coenzyme Q10 is a potent antioxidant to protect against LDL oxidation and may be a good alternative to reduce the risk of atherosclerosis and coronary heart disease and other associated free radical health problems.

Coenzyme Q10 is now used as a nutritional supplement due to its antioxidant properties and is beneficial in the treatment of various human diseases when administered orally.

Coenzyme Q10, like most flavin-dependent enzymes, catalyzes oxidation-reduction processes in primary metabolic pathways such as the citric acid cycle, β-oxidation and amino acid degradation. Coenzyme Q10 is a key component for bioenergetics and antioxidant protection in the cell. In recent years, research on diseases related to Coenzyme Q10 deficiency has highlighted the essential role of lipid or cell physiology. It is important to take into account that CoQlO levels are also affected during aging and neurodegenerative diseases. Studies show that mitochondrial DNA depletion syndromes are frequently associated with CoQlO deficiency.

The reduced form of Coenzyme Q10 (ubiquinol, Q (10) H (2)) is an effective antioxidant in biological membranes. In recent years, a particular interest has grown in the molecular effects of Coenzyme Q10 supplementation on mechanisms related to the prevention of DNA damage. Dietary supplementation with coenzyme Q10, is a key component of the electron transport chain and a powerful antioxidant, rescued many of the harmful effects of nutritional programming on cardiac aging. Early recognition of Coenzyme Q10 deficiency is essential to establish adequate and timely treatment, thus avoiding irreversible tissue damage. Supplementation of exogenous coenzyme Q10 has protective effects against the generation of free radicals through the reduction of postprandial oxidative stress, helps to modify the levels of postprandial antioxidant proteins and in the reduction of the expression of antioxidant postprandial genes in mononuclear cells of peripherally blood. The main functions of coenzyme Q10 within the anti-aging supplement are:

• Cellular metabolism.

• Electron transport.

HESPERIDINE

Hesperidin protects cortical cells from primary cultures against oxidative neuronal damage induced by H2O2 or xanthine and xanthine oxidase.

It is also used in the treatment of varicose veins, due to its benefit by regulating apoptosis.

Among flavonoids, hesperidin is found mostly in tangerine and sweet orange. The physiological broth of citrus fruits has good potential as sources of different bioactive compounds and antioxidants.

Results suggest that hesperidin can act on the bone by the same mechanism as that of statins. Observations clearly demonstrate that hesperidin provides strong cellular antioxidant protection against the harmful effects of hydrogen peroxide. The main functions of hesperidin within the anti-aging supplement are:

• Diuretic activity.

• It is anti hypertensive. ISOTIOCIAMATES

Studies have shown that isothiocyanates can suppress tumor growth by blocking enzymes. Among the blocking agents are the idols and isothiocyanates (ITCs) of cruciferous plants which prevent carcinogens from damaging cell targets, such as DNA, RNA and proteins, since they have the ability to block metabolic activation of carcinogens through the inhibition of the activity of Phase I enzymes.

Suppressing agents such as isothiocyanates prevent the development of the tumor and its mechanisms of action are: blockage of the cell cycle, modulation of the apoptotic process (they can have a dual effect, that is, induce or inhibit cell death by apoptosis, depending on the dose administered) and inhibition of cell signaling pathways that are stimulated in tumor cells.

Studies show the beneficial effects of glucosinolates and isothiocyanates in the models of carcinogenesis, and cardiovascular and neurological diseases, as well as in the intervention studies of their safety, pharmacokinetics, and efficacy in humans.

Isothiocyanates suppress tumor growth by generating reactive oxygen species or by inducing the arrest of the cycle that leads to apoptosis.

In mammalian tissues, sub-toxic concentrations of isothiocyanates can provide protective effects against cancer and other diseases partially by induction of glutathione transferases (GSTs) and other detoxification enzymes. Isothiocyanates have a biphasic effect on cell growth and migration. The benefits and risks of isothiocyanates are not only determined by doses, but also affected by interactions with selenium.

There is evidence that GST (glutathione S-transferase), derived from isothiocyanates may have an even wider relevance to cancer, since they can directly modulate the activity of a number of protein targets, including other redox enzymes in the pathways and in signaling networks of cell division and cell cycle control. Several studies have shown that folic acid, vitamin B12, choline, zinc, selenium, dietary polyphenols such as isothiocyanates are able to interact with epigenetic mechanisms and ultimately gene expression.

Hydroxyphenolic compounds such as isothiocyanates have the potential to improve cardiovascular problems related to aging such as hypertension, atherosclerosis and dyslipidemia. Results suggest that high levels of isothiocyanate exposure in the diet could reduce the risk of pancreatic cancer. Epidemiological evidence suggests a strong inverse relationship between the nutritional intake of cruciferous vegetables and the incidence of cancer.

Isothiocyanates have been extensively studied in experimental in vitro and in vivo carcinogenesis models for their chemopreventive properties of cancer. The main functions of isothiocyanates within the anti-aging supplement are:

• Suppress tumor growth by blocking enzymes.

ALICINA (ALUNA)

Anthocyanins are natural polyphenols studied extensively in decades and that over time have been refined both obtaining and extraction, as well as being obtained by total or semi-total synthesis

Phytochemicals derived from natural products (fruits, vegetables and certain species) are preventive chemo agents, which include capsaicin, trans-anetole, thymoquinone, diosgenin, allicin and can not only reduce the risk of acquiring a specific cancer but also suppress the proliferation of cancer cells, as well as the inhibition of growth factor pathways and those of nuclear factor-κΒ, AP-1, Akt, MAPK, Wnt, Notch, p53, AR, ER, and JAK-STAT, in addition to inducing apoptosis

Epidemiological studies suggest that regular consumption of polyphenols and secondary metabolites of plants are related to a decrease in the risk of cardiovascular diseases, diabetes, arthritis and cancer. The most abundant flavonoids in plants are water-soluble anthocyanins and glycosylated and nonacetylated pigments, and the consumption of these compounds significantly increases the antioxidant potential in serum

Epidemiological studies of anthocyanins suggest that their consumption decreases the risk of diseases Cardiovascular (CVD), which is the most common cause of male and female mortality. Anthocyanins frequently interact with other phytochemicals and show synergistic biological effects.

Nowadays the importance of the pharmaceutical and food industry is based mainly on the evidence of the scientific work that shows the beneficial effects in the prevention of cardiovascular diseases, as well as the neurological conditions.

Different mechanisms have been detected for these effects, the main ones being the antihypertensive and protective activities of the endothelium that they have, as well as the anti-atherogenic activity and their interaction with estrogenic receptors.

The main functions of allicin within the anti-aging supplement are:

· Stimulate circulation.

• Decrease platelet aggregation.

ELAGIC ACID

In vitro studies show that elagitianins in concentrations of 10-100 μΜ, show relevant effects of anti-atherogenic, anti-thrombotic, anti-inflammatory, anti-angiogenic properties, which supports the molecular mechanisms that give benefits to vascular health.

Applications of swamp berries (cloudberry) containing vitamin C and eleagotanins with a high Index of Elegic Acid with biological activities of the anti-carcinogenic, anti-imitating and anti-oxidant type.

Breast cancer studies revealed that ellagic acid significantly inhibits the expression of cancer growth. The molecular coupling simulation indicates that the acid forms hydrogen bonds with aromatic interactions in the ATP junction region of the VEGFR-2 kinase unit. And that together they can carry out an anti-angiogenesis effect via VEGFR-2 in breast cancer.

The main functions of ellagic acid within the anti-aging supplement are:

· Biological activities of the anti-carcinogenic, anti-mutant and anti-oxidant type.

Anthocyanates

Anthocyanins are water-soluble pigments that are found in the vacuoles of plant cells and that give the leaves, flowers and fruits red, purple or blue color.1 From a chemical point of view, anthocyanins belong to the group of flavonoids and they are glycosides of anthocyanidins, that is, they are constituted by a molecule of anthocyanidin, which is aglycone, to which sugar is attached through a glucosidic bond. Its functions in plants are multiple, from the protection of ultraviolet radiation to the attraction of pollinating insects.

The interest in anthocyanin pigments has recently intensified due to their pharmacological and therapeutic properties. Therefore, in addition to your paper works as food dyes, anthocyanins are potential agents in obtaining products with added value for human consumption. They exert known therapeutic effects that include the reduction of coronary heart disease, anti-tumor, anti-inflammatory and antidiabetic effects, as well as the improvement of visual acuity and cognitive behavior. The therapeutic effects of anthocyanins are related to their antioxidant activity. Studies with anthocyanin fractions from wine have shown that they are effective in trapping reactive oxygen species, as well as inhibiting the oxidation of lipoproteins and platelet aggregation.

The main functions of Anthocyanins in the anti-aging supplement are:

• Improve elasticity and vascular function. VITAMIN A

The intake of total vitamin A and C helps relieve or improve metabolic syndrome in women. Vitamin A and provitamin A (beta-carotene) protect the activity of lipid per oxidation.

Vitamin A and its active metabolite (retinoic acid) are essential for the development and function of many tissues including the immune system. Induction of mucosal receptors in T and B cells by mucosal dendritic (DC) cells depends on the presence of vitamin A. Numerous cellular functions, including bone cell functions, and vision are mediated by vitamin A. Retinoic acid, the main active biological form of vitamin A, influences the expression of collagen, laminins, entactin, fibronectin, elastin. and proteoglycans, which are the main components of the extracellular matrix.

High doses of Retinoic Acid can lead to cytotoxicity, which is probably the most used as a potential supplement in the daily diet of one to prevent or suppress the progression of cancer (in melanoma, hepatoma, lung cancer, breast cancer and prostate cancer).

Vitamin A has an important effect on the chronic inflammatory response. A deficiency of vitamin A increases the response of a type T-helper 1 (Thl), increases the levels of pro-inflammatory cytokines, increases the expression of leptin, resistin and decoupling proteins (PCU) and promotes adipogenesis. The main functions of Vitamin A within the anti-aging supplement are:

• Avoid vision loss

CATEQUINAS AND POLIFENOLZS (GREEN TEA)

Polyphenols have an important role in reversing the loss of plasticity and recovery of neuronal lesions associated with aging. The catechins present in green tea have the ability to prevent atherosclerosis, hypertension, endothelial dysfunction, cardiac ischemic diseases, cardiomyopathy, cardiac hypertrophy and congestive heart failure as it reduces oxidative stress, prevents inflammation, reduces platelet aggregation and stops smooth muscle vascular cell proliferation. In addition, catechins support an effect by inducing antioxidant enzymes, as well as inhibiting pro-oxidant enzymes and sweeping free radicals. They inhibit the transcriptional factor NF-κΒ whose production is mediated by cytokines and adhesion molecules.

Green tea extract can modulate brain activity in the prefrontal lateral dorsal cortex, which is a key area in the memory process in the human brain.

The consumption of green tea catechins has beneficial effects on blood pressure and lipid parameters. The differences in the tone of small blood vessels from the impact of catecholamine O-methyl transferase after ingestion of green tea extract is to improve blood pressure and vascular function.

In a systematic review it follows that there is potential at the molecular level with data that support evidence of the role of green tea components in the prevention and treatment of ovarian cancer.

The review of green tea catechins promotes the development of a joint treatment strategy with anticancer drugs to increase their therapeutic potential, in addition to lowering the cytotoxicity and cost of it. They could play an intervention and prevention role in prostate cancer populations that Consume large amounts of green tea usually have the lowest incidence of this type of pathology.

Epidemiological studies demonstrate the beneficial effects of green tea and its extract rich in cantechin 3 gallato epigallo in weight management, glucose control and cardiovascular risk factors.

Green tea catechins inhibit the proliferation of breast cancer cells and block their carcinogenesis, the proposed mechanisms are: modulation of extracellular signals, induction of apoptosis through redox reduction or through modulation epigenetic alterations.

The main functions of Catechins and Polyphenols (Green Tea) within the anti-aging supplement are: • Reduce inflammatory markers. VITAMIN C

In the body, vitamin C helps to develop and maintain collagen, bones, teeth and blood vessels, as well as collaborate in the control of infections, the absorption of iron and is used as a treatment for the state of generalized inflammation in addition to decreasing the systolic and diastolic pressure.

Acute administration of vitamin C is able to reduce the cardiovascular adrenergic response of hypertensive patients and suggests that oxidative stress is involved in the regulation of sympathetic activity in essential hypertension. It is concluded that 200 mg per day is the optimal daily intake of vitamin C for the majority of the adult population, which maximizes the potential health benefits, as well as the lower risk of side effects.

The main functions of vitamin C within the anti-aging supplement are:

• Collagen production.

• Iron absorption.

· Decreased inflammation

Astaxanthin

The intake of Astaxanthin improves the activity of superoxide and suppresses the total production of hydroxyperoxides in the human aqueous humor, indicating that astaxanthin has suppressive effects in various diseases related to oxidative stress.

Astaxanthin has an unusual antioxidant activity with benefits on the prevention of cardiovascular diseases, the increase of the immune system, bioactivity against helicobacter pylory and prevention of cataracts.

Astaxanthin inhibits the oxidation of low density lipoproteins, which probably contributes to the prevention of atherosclerosis.

Astaxanthin, as well as omega 3 fatty acids individually or in combination protect against oxidative stress.

The astaxanthin extract rich in Haematococcus pluvialis improves cognitive function in healthy elderly individuals. In cell cultures, Astaxanthin protects the mitochondria against endogenous oxygen radicals, preserving its antioxidant capacity (redox) and improving efficiency in energy production, in addition to its effects can go beyond protection against oxidative stress and inflammation

The main functions of Astaxanthin within the anti-aging supplement are:

· Suppress oxidative damage.

RESVERATROL

Resveratrol is useful in therapy on endothelial growth factor (VEGF) as it acts on age-related macular degeneration. Resveratrol attenuates cardiovascular, cerebrovascular, and peripheral vascular risk.

Resveratrol, a phytoalexin polyphenol, present in red wine and grapes, possesses various biochemical and physiological properties, including estrogenic, anti-platelet activity, and anti-inflammatory properties, as well as a wide range of health benefits ranging from chemo prevention until cardio protection.

Neuroprotective effects have been found in neurodegeneration models (Alzheimer's, Parkinson's or Huntington's disease, or various neuropathies), ischemia and brain and spinal cord injuries thanks to the use of Resveratrol.

Resveratrol is a potent antioxidant and an anti-inflammatory agent. Reduces the expression of adhesion molecules cell, monocyte colony stimulation factors, matrix metalloproteinases, and growth factors; and inhibits platelet aggregation and proliferation of vascular smooth muscle cells. It reduces serum levels of total cholesterol, triglycerides (TG) and increases high-density lipoprotein cholesterol, inhibits the expression of C-reactive protein and decreases levels of advanced glycation end products and its receptor in vascular tissue. Risk factors for plaque rupture are reduced.

There is a positive association of resveratrol intake with lung function in the general population, it shows a greater association with strengthened vital capacity. Resveratrol reduces myocardial damage during ischemic perfusion, modulation of vascular cellular functions, inhibition of LDL oxidation, and suppression of platelet aggregation. Resveratrol was associated with beneficial changes in blood lipid profiles, fasting blood glucose and heart rate, suggesting that consumption of resveratrol decreases cardiovascular risk factors (CV).

The main functions of resveratrol within the anti-aging supplement are:

• Reduce the risk of Lung Cancer, Cardiovascular Disease and prostate.

· Reduction of inflammatory markers. BORON

Boron deficiency or a decrease results in poor growth, reduction of some blood indices, and particularly steroid hormone concentrations. This interaction in the metabolism affects in several clinical conditions such as arthritis.

Boron supplementation does not adversely affect Magnesium. However, its depletion causes changes similar to those presented by women in the menopause stage in relation to osteoporosis. These elements are necessary for optimal calcium metabolism and prevent excessive bone loss that frequently occurs in postmenopausal women and older men.

It influences the activity of many metabolic enzymes, as well as the metabolism of steroid hormones, and various micronutrients, including calcium, magnesium and vitamin D; It helps increase bone density, improves arthritis, lipid profile and mental function. Its deficiency results in decreased bone health, brain function and immune response.

It improves the response of estrogenic therapy, increases psychomotor abilities and cognitive processes of attention and memory. It significantly impacts a large number of metabolic processes such as the increase in plasma testosterone and vitamin D and a decrease in plasma HDL cholesterol.

On the other hand, in relation to obesity it has been found that the amounts of blood boron found were lower in obese subjects than in non-obese subjects, so it is thought that there is an inverse relationship. The main functions of Boron within the anti-aging supplement, are mainly for men:

• Help the production of testosterone.

• Decrease the risk of prostate cancer.

· Help calcium and magnesium metabolism in bones, prevent arthritis.

• Improve brain function and immune response.

• Help maintain an adequate body mass index thereby avoiding weight gain.

SOY

SOYA ISOFIAVONES

Most breast cancers are positive receptor hormones, so isoflavones should be considered a potent anti-cancer therapeutic agent.

The extracts of biotransformed soybean in rich extract of aglicone were able to increase the production of Nitric Acid, as well as of prostaglandins E2, demonstrating that in endothelial cells in vitro can be used as therapeutic agents against the development of atherosclerosis.

Soy isoflavones are moderately effective in relieving symptoms of menopause, and are also associated with a lower risk of breast and endometrial cancer.

Soy isoflavones show mild and slow but positive effects in reducing hot flashes in menopause, compared to estradiol.

Soy isoflavone supplementation seems to have a positive effect on improving cognitive function and visual memory in post menopausal women. Including soy foods in the diet helps improve the health of post-menopausal women. Generally speaking, isoflavones are di-phenolic compounds that have various functions in cell mechanisms: they generally form a phenotype of inert cells in some types of cancers and also improve connective tissue in the cell anchor through the effects on proteins In the extracellular matrix, they also affect the integrity of the cytoskeleton, as well as the effects related to the flow and involvement of calcium ions for the retraction, differentiation or proliferation, which involve mechanical states. On the other hand, they make a "silent" increase or decrease in the tension / fluidity of the membrane, which depends on the polarity and the number of arrangements of the functional groups involved in Isoflavone. Finally they cause inhibitory effects on the circulation of vesicles: endo / exocitosisy are functional morpho defining of cell mechanics.

The main functions of Isoflavones within the anti-aging supplement are mainly for women:

• Function as an anticancer agent.

• Protective radius, with properties to improve the profile of protein C.

• Decrease the incidence of atherosclerosis.

· Help increase estradiol.

• Improve cognitive and visual function in postmenopausal women. • Reduce hot flashes, as well as other side effects of menopause

The concentration of the components of the anti-aging supplement are:

- Caffeine from 0.46 to 0.51%

- Blueberries from 0.46 to 0.51%

- Ursolic acid from 0.046 to .05%

- Turmeric from 9.22 to 10.23%

- Citrulline from 0.018 to 0.02%

- Lamiaceae type Salvia hispanic L from 46.11 to 51.16%

- Potassium from 2.76 to 3.07%

- Vitamin D of 0.00005%

- Calcium from 11.06 to 12.28%

- Zinc from 0.73 to 0.80%

- Sulfur from 6.45 to 7.16%

- Magnesium from .013 to 0.02%

- Coenzyme Q10 (übiquinone) from 1.38 to 1.53%

- Hesperidine 0.18 to 0.20%

- Isothiocyanates from 0.00018 to 0.0002%

- 0.00002% allicin

- 0.01% ellagic acid

- Anthocyanates from 0.10 to 0.18%

- Vitamin A from 0.0013 to 0.0015%

- Catechins and Polyphenols (Green Tea) from 0.31 to 0.36%

- Vitamin C from 0.55 to 0.61%

- Astaxanthin from 10.23 to 18.44%

- Resveratrol from 1.02 to 1.38%

- Boron from 0.046 to 0.05%

- Soy Isoflavones from 0.73 to 0.82%

In order to have a better result since the needs depend on gender and bio-rhythm (cycle biological) of the human body, the anti-aging supplement of the present invention, can vary the formulation of the components and their concentration in 4 supplements:

1. Morning anti-aging supplement for men.

2. Morning anti-aging supplement for women.

3. Evening anti-aging supplement for men.

4. Evening anti-aging supplement for women.

The concentration of the components of the morning anti-aging supplement for men is:

- 0.59% caffeine

- 0.59% blueberries

- 0.06% ursolic acid

- Turmeric of 11.78%

- 0.02% citrulline

- Lamiaceae type Salvia hispanic L of 58.95%

- 3.54% potassium

- Vitamin D of 0.00005%

- Calcium of 14.14%

- 0.09% zinc

- 8.25% sulfur

- 0.02% magnesium

- Coenzyme Q10 (Ubiquinone) of 1.77%

- Hesperidine 0.24%

- 0.0002% isothiocyanates

The concentration of the components of the morning anti-aging supplement for women is:

- 0.59% caffeine

- 0.59% blueberries

- 0.06% ursolic acid - Turmeric of 11.78%

- 0.02% citrulline

- Lamiaceae type Salvia hispanic L of 58.95%

- 3.54% potassium

- Vitamin D of 0.00005%

- Calcium of 14.14%

- 0.09% zinc

- 8.25% sulfur

- 0.02% magnesium

- Coenzyme Q10 (übiquinone) of 1.77%

- Hesperidine 0.24%

- 0.0002% isothiocyanates

The concentration of the components of the evening anti-aging supplement for men is:

- 0.0001% allicin

- 0.054% ellagic acid

- 0.87% anthocyanates

- Vitamin A of 0.0065%

- Catechins and Polyphenols (Green Tea) of 1.75%

- Vitamin C of 2.63%

- 87.85% astaxanthin

- 6.58% Resveratrol

. - 0.21% Boron

The concentration of the components of the evening anti-aging supplement for women is:

- 0.00012% allicin

- 0.097% ellagic acid

- 0.78% anthocyanates

- Vitamin A of 0.011%

- Catechins and Polyphenols (Green Tea) of 2.34%

- Vitamin C of 4.68%

- 78.03% astaxanthin - Resveratrol of 7.80%

- Soyade Isoflavones 6.24%

The anti-aging supplement may be in usual forms, such as solution, suspension, emulsion, powder, tablet, capsule, solid, liquid or ointment.

EXAMPLES

The following example illustrates one of the preferred embodiments for carrying out the present invention, which should be considered merely as illustrative, and therefore should not be considered as a limitation of the present invention. Example 1: Preparation of 1,000 grams of the anti-aging supplement for the taking of men in the morning, reason for the present invention.

To make 1,000 grams of the morning anti-aging supplement for men, the components are mixed with the following amounts:

- Caffeine 5.89 gr.

- Blueberries 5.89 gr.

- Ursolic acid 0.59 gr.

- Turmeric 117.83 gr.

- Citrulline 0.24 gr.

- Lamiaceae type Hispanic sage L 589.17

- Potassium 35.35

- Vitamin D 0.00059 gr.

- Calcium 141.40 gr.

- Zinc 0.94 gr.

- Sulfur 82.48 gr.

- Magnesium 0.18 gr.

- Coenzyme Q10 (Ubiquinone) 17.68 gr.

- Hesperidine 2.36 gr. - Isothiocyanates 0.0024 gr.

Xj «mplo 2: Preparation of 1,000 grams of the anti-aging supplement for the taking of women in the morning, reason for the present invention.

To make 1,000 grams of the morning anti-aging supplement for women, the components are mixed with the following amounts:

- Caffeine 5.89 gr.

- Blueberries 5.89 gr.

- Ursolic acid 0.59 gr.

- Turmeric 117.83 gr.

- Citrulline 0.24 gr.

- Lamiaceae type Hispanic sage L 589.17

- Potassium 35.35

- Vitamin D 0.00059 gr.

- Calcium 141.40 gr.

- Zinc 0.94 gr.

- Sulfur 82.48 gr.

- Magnesium 0.18 gr.

- Coenzyme Q10 (übiquinone) 17.68 gr.

- Hesperidine 2.36 gr.

- Isothiocyanates 0.0024 gr.

Example 3: Preparation of 1,000 grams of the anti-aging supplement for the taking of men in the afternoon, reason for the present invention.

To make 1,000 grams of the evening anti-aging supplement for men, the components are mixed with the following amounts:

- Alicina 0.00098 gr.

- Ellagic Acid 0.54 gr

- Anthocyanates 8.78 gr. - Vitamin A 0.065 gr.

- Catechins and Polyphenols (Green Tea) 17.57 gr.

- Vitamin C 26.35 gr

- Astaxanthin 878.57 gr

- Resveratrol 65.89 gr.

- Boron 2.19 gr

Example 4: Preparation of 1,000 grams of the anti-aging supplement for taking women in the afternoon, reason for the present invention.

To make 1,000 grams of the evening anti-aging supplement for women, the components are mixed with the following amounts:

- Allicin 0.0011 gr

- Ellagic Acid 0.97 gr.

- Anthocyanates 7.80 gr.

- Vitamin A 0.11 gr.

- Catechins and Polyphenols (Green Tea) 23.41 gr.

- Vitamin C 46.82 gr.

- Astaxanthin 780.39 gr.

- Resveratrol 78.03 gr.

- Soyade Isoflavones 62.43 gr.

Claims

Having sufficiently described the invention, what is contained in the following claims clauses is claimed as property.

1. An anti-aging supplement characterized in that it comprises:

i. Caffeine;

ii. Blueberries;

iii. Ursolic acid;

iv. Turmeric;

V. Citrulline;

saw . Lamiaceae;

vii. Potassium;

viii Vitamins;

ix. Calcium;

X. Zinc;

xi. Sulfur;

xii. Magnesium;

xiii. Coenzyme Q10;

xiv. Hesperidine;

XV. Isothiocyanates;

xvi. Allicin;

xvii. Ellagic Acid;

xviii. Anthocyanates;

xix. Catechins and Polyphenols;

XX. Astaxanthin;

xxi. Resveratrol;

xxii. Boron; Y,

xxiii. Soy Isoflavones.

2. The supplement of the preceding claim, wherein the Vitamins are of type A, D and C.

3. The supplement of the preceding claims, wherein the Lamiaceae are of the Hispanic Salvia L type known as Chia. 4. The supplement of claim 3, wherein the Chia is powdered.

5. The supplement of the preceding claims, wherein the source of Catechins and Polyphenols is Green Tea.

6. The supplement of the preceding claims, wherein the amount of Caffeine is from 0.46 to 0.51%. 7. The supplement of the preceding claims, wherein the amount of Blueberries is from 0.46 to 0.51%.

8. The supplement of the preceding claims, wherein the amount of Ursolic Acid is from 0.046 to .05%.

9. The supplement of the preceding claims, wherein the amount of Turmeric is 9.22 to 10.23%.

10. The supplement of the preceding claims, wherein the amount of Citrulline is from 0.018 to 0.02%.

11. The supplement of the preceding claims, wherein the amount of Chia is from 46.11 to 51.16%.

The supplement of the preceding claims, wherein the amount of Potassium is from 2.76 to 3.07%.

13. The supplement of the preceding claims, wherein the amount of.

14. The supplement of the preceding claims, wherein the amount of Vitamin D is 0.00005%.

15. The supplement of the preceding claims, wherein the amount of Calcium is from 11.06 to 12.28%.

16. The supplement of the preceding claims, wherein the amount of Zinc is from 0.73 to 0.80%. 17. The supplement of the preceding claims, wherein the amount of Sulfur is from 6.45 to 7.16%.

18. The supplement of the preceding claims, wherein the amount of Magnesium is from .013 to 0.02%.

19. The supplement of the preceding claims, wherein the amount of Coenzyme Q10 is from 1.38 to 1.53%.

20. The supplement of the preceding claims, wherein the amount of Hesperidin is 0.18 to 0.20%.

21. The supplement of the preceding claims, wherein the amount of isothiocyanates is from 0.00018 to 0.0002%.

22. The supplement of the preceding claims, wherein the amount of allicin is 0.00002%.

The supplement of the preceding claims, wherein the amount of Ellagic Acid is 0.01%.

24. The supplement of the preceding claims, wherein the amount of anthocyanates is from 0.10 to 0.18%.

25. The supplement of the preceding claims, wherein the amount of Vitamin A is from 0.0013 to 0.0015%.

26. The supplement of the preceding claims, wherein the amount of Catechins and Polyphenols is of

0.31 to 0.36%.

27. The supplement of the preceding claims, wherein the amount of Vitamin C is from 0.55 to 0.61%.

28. The supplement of the preceding claims, wherein the amount of Astaxanthin is from 10.23 to 18.44%.

29. The supplement of the preceding claims, wherein the amount of Resveratrol is from 1.02 to 1.38%.

30. The supplement of the preceding claims, wherein the amount of Boron is from 0.046 to 0.05%. 31. The supplement of the preceding claims, wherein the amount of Isoflavones is from 0.73 to 0.82%.

32. The supplement of the preceding claims, wherein the components and their concentration to be consumed in the morning by a man, are:

i. 0.59% caffeine

ii. 0.59% blueberries

iii. 0.06% Ursolic Acid

iv. Turmeric of 11.78%

v. 0.02% Citrulline

saw. Chia of 58.95%

vii. 3.54% potassium

viii Vitamin D of 0.00005% ix. Calcium of 14.14%

X. Zinc of 0.09%

xi. 8.25% sulfur

xii. 0.02% Magnesium

xiii. Coenzyme Q10 of 1.77%

xiv. Hesperidine 0.24%

XV. 0.0002% isothiocyanates

33. The supplement of claims 1 to 31, wherein the components and their concentration to be consumed in the morning by a woman, are:

i. 0.59% caffeine

ii. 0.59% blueberries

iii. 0.06% Ursolic Acid

iv. Turmeric of 11.78%

V. Citrulline 0.02%

saw . Chia of 58.95%

vii. 3.54% potassium

viii Vitamin D of 0.00005%

ix. Calcium of 14.14%

X. Zinc of 0.09%

xi. 8.25% sulfur

xii. 0.02% Magnesium

xiii. Coenzyme Q10 of 1.77%

xiv. 0.24% Hesperidine

XV. 0.0002% isothiocyanates

34. The supplement of claims 1 to 31, wherein the components and their concentration to be consumed in the afternoon or evening by a man, are:

i. 0.0001% allicin

ii. 0.054% Ellagic Acid

iii. 0.87% anthocyanates

iv. 0.0065% Vitamin A v. Catechins and Polyphenols (Green Tea) of 1.75% vi. Vitamin C of 2.63%

vii. Astaxanthin 87.85%

viii 6.58% Resveratrol

ix. 0.21% Boron

35. The supplement of claims 1 to 31, wherein the components and their concentration to be consumed in the afternoon or evening by a woman, are:

i. 0.00012% allicin

ii. 0.097% ellagic acid

iii. 0.78% anthocyanates

iv. 0.011% Vitamin A

V. Catechins and Polyphenols (Green Tea) of 2.34% vi. Vitamin C of 4.68%

vii. 78.03% astaxanthin

viii 7.80% Resveratrol

ix. Soyade Isoflavones 6.24%

The supplement of the preceding claims, wherein the presentation of said supplement is in solution.

37. The supplement of claims 1 to 35, wherein the presentation of said supplement is in suspension.

38. The supplement of claims 1 to 35, wherein the presentation of said supplement is in emulsion. 39. The supplement of claims 1 to 35, wherein the presentation of said supplement is powder.

40. The supplement of claims 1 to 35, wherein the presentation of said supplement is in tablets.

41. The supplement of claims 1 to 35, wherein the presentation of said supplement is in capsules.

42. The supplement of claims 1 to 35, wherein the presentation of said supplement is in liquid.

43. The supplement of claims 1 to 35, wherein the presentation of said supplement is in solid. 44. The supplement of claims 1 to 35, wherein the presentation of said supplement is ointment.