WO2017107600A1 - 一种精密过滤输液容器 - Google Patents

一种精密过滤输液容器 Download PDF

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Publication number
WO2017107600A1
WO2017107600A1 PCT/CN2016/100022 CN2016100022W WO2017107600A1 WO 2017107600 A1 WO2017107600 A1 WO 2017107600A1 CN 2016100022 W CN2016100022 W CN 2016100022W WO 2017107600 A1 WO2017107600 A1 WO 2017107600A1
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WO
WIPO (PCT)
Prior art keywords
sealing
filtrate chamber
infusion
liquid
cavity
Prior art date
Application number
PCT/CN2016/100022
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English (en)
French (fr)
Inventor
胡绍勤
Original Assignee
胡绍勤
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Filing date
Publication date
Application filed by 胡绍勤 filed Critical 胡绍勤
Publication of WO2017107600A1 publication Critical patent/WO2017107600A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1406—Septums, pierceable membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
    • A61J1/1456—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using liquid filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/36—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests with means for eliminating or preventing injection or infusion of air into body
    • A61M5/38—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests with means for eliminating or preventing injection or infusion of air into body using hydrophilic or hydrophobic filters
    • A61M5/385—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests with means for eliminating or preventing injection or infusion of air into body using hydrophilic or hydrophobic filters using hydrophobic filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M2005/1401—Functional features
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters
    • A61M2205/7536—General characteristics of the apparatus with filters allowing gas passage, but preventing liquid passage, e.g. liquophobic, hydrophobic, water-repellent membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters
    • A61M2205/7545—General characteristics of the apparatus with filters for solid matter, e.g. microaggregates

Definitions

  • the invention relates to the field of medical packaging materials, in particular to a precision filtration infusion container.
  • Infusion therapy is one of the important ways in traditional treatments. However, a large amount of insoluble particles are present in the infusion, and insoluble particles due to insufficient dissolution of the drug occupy a major portion.
  • the traditional infusion container only provides the function of holding the liquid medicine, and cannot filter the insoluble particles in the medicine liquid.
  • the ordinary filtration infusion sets have a certain height difference between the filtration membrane and the infusion container, and the liquid pressure is large, so that some of the critical pore size particles will also pass.
  • the filter membrane enters the body.
  • multiple sets of drugs and long-term infusions on the same infusion set will occur.
  • the excessive number of particles in the liquid is an important factor causing the reaction, and the infusion set used in the infusion process, because of the long-term use, greatly reduces or loses the filtering effect of the filter, and even becomes A source of pollution that increases particulates.
  • different drug particles will stay on the filter screen, increasing the risk of mutual reaction.
  • the filter device there is an infusion container to which the filter device is applied. Since the gas in the filtrate chamber cannot be discharged before the infusion, the gas in the filtrate chamber may enter the infusion tube with the infusion needle, which does not meet the requirements of clinical safety application.
  • the current precision filtration infusion container requires multiple bonding and assembly of various components, increasing the number of processes, increasing costs, and increasing patient medical expenses.
  • the present invention provides a precision filtration infusion container which can filter insoluble particles in an injection solution and solve the problem that the gas in the filtrate chamber is discharged before infusion and can reduce the production cost.
  • a precision filtration infusion container comprises a container body and a sealed cavity separated from the container body by a sealing device;
  • the chemical liquid filtering device comprises at least one chemical liquid filtering film
  • At least one of the liquid filtration membranes forms a filtrate chamber around the exhaust device, and the filtrate chamber is suspended in the sealed chamber;
  • the container body is provided with an infusion puncture position.
  • the inner cavity of the sealed cavity is a hollow cylindrical shape.
  • the sealing device is a releasable sealing block which is internally recessed and which is externally contracted to the distal end, and the distal end of the outer portion of the releasable sealing block is connected to the inner wall of the sealing cavity.
  • the recessed portion of the releasable sealing block is connected with a toggle actuating lever, and the releasable sealing block is provided with a frangible portion at a position connecting the inner wall of the sealing cavity, and an outer side of the dialing actuating lever is provided with an operating ring.
  • the sealing device is a main body internal depression And the externally distally retracted to the tip of the releasable sealing block, the distal end of the outer portion of the releasable sealing block is connected to the inner wall of the sealing cavity, and the concave portion of the releasable sealing block is connected with a toggle enable Rod.
  • the releasable sealing block is provided with a frangible portion at the end of the inner wall of the sealing cavity, and an outer side of the toggle actuating lever is provided with an operating ring.
  • the sealing device is a sealing plate transversely disposed in the sealing cavity, and the upper and lower sides of the sealing plate are respectively welded and sealed with the inner wall of the sealing cavity.
  • the medical liquid filtering device comprises at least one medical liquid filtration membrane.
  • the medical liquid filtration membrane is a hollow cylinder or a hollow cylinder provided with an opening.
  • the top end of the filtrate chamber is provided with an exhaust device.
  • the top end of the filtrate chamber is provided with an exhaust device;
  • the exhaust device is a horizontally arranged gas permeable membrane, or the exhaust device comprises a horizontally disposed exhaust passage and is located An exhaust valve in the exhaust passage.
  • At least one of the medical liquid filtration membranes forms a filtrate chamber around the exhaust device.
  • At least one side wall of the filtrate chamber is an infusion puncture site.
  • the filtrate chamber is provided for holding
  • the filtrate chamber has a hollow support frame.
  • the inner wall of the sealing cavity is provided with a snap structure for fixing the support frame.
  • At least one of the liquid chemical filtration membranes forms a filtrate chamber around the exhaust device, and the filtrate chamber is suspended in the sealed chamber, and one side wall of the filtrate chamber forms an infusion puncture position.
  • At least one of the liquid chemical filtering membranes forms a filtrate chamber around the exhaust device, and the filtrate chamber is suspended in the sealed cavity by a fastening structure of the fixed support frame, and the filtrate chamber is One side wall forms an infusion puncture site.
  • the bottom of the filtrate chamber is provided with a sealing rubber block.
  • At least one of the liquid chemical filtration membranes forms a filtrate chamber around the exhaust device, and a bottom of the filtrate chamber is provided with a closed rubber block, and the filtrate chamber is suspended in the sealed cavity.
  • At least one of the liquid chemical filtering membranes forms a filtrate chamber around the exhaust device, and a bottom of the filtrate chamber is provided with a sealing rubber block, and the filtrate chamber is suspended by a fastening structure of the fixed support frame.
  • the sealed gel block forms an infusion puncture site in the sealed cavity.
  • the exhaust device is a horizontally disposed gas permeable membrane.
  • the exhaust device includes a horizontally disposed exhaust passage and an exhaust valve located in the exhaust passage.
  • the exhaust passage includes a long groove concavely disposed in at least one inner cavity, and the exhaust valve is a cylindrical rod or a spherical valve located in the exhaust passage.
  • a chemical liquid filtration membrane is disposed around the exhaust device, and all the circumferences of the chemical liquid filtration membrane are tightly connected to the inner wall of the sealing chamber.
  • the liquid filtration membrane splicing portion, the liquid chemical filtration membrane and the exhaust device of each layer, and the liquid filtration membrane and the exhaust device of each layer and the sealing rubber block are disposed between the layers.
  • the sealing cavity is provided with a sealing rubber plug.
  • the container body is provided with an infusion puncture position.
  • the container body is provided with a liquid medicine supplementation puncture position.
  • the bottom of the sealing cavity is a releasable sealing cover, and a loopable franging portion is disposed around the releasable sealing cover, and the bottom of the releasable sealing cover is provided with an open cavity pull ring.
  • a ring of snap rings disposed parallel to the releasable sealing cover is disposed in the sealed cavity, and the sealing rubber plug is fastened between the releasable sealing cover and the snap ring.
  • the inner cavity of the container body and the sealing cavity are both columnar structures, and the cross-sectional diameter of the container body is larger than the cross section of the sealing cavity. path.
  • the top of the container body is provided with a lifting eye for hanging.
  • the invention has the beneficial effects that the precision filtering infusion container separates the container body and the sealing cavity by a sealing device, and stores the chemical liquid in the container body in a storage state or when not in use, and makes the liquid medicine when needed. It can enter the sealed cavity, and the infusion puncture is located in the filtrate cavity. During the infusion process, the liquid is filtered through the liquid filtration membrane and then infused through the infusion puncture position, which can better guarantee the purity of the liquid, thus Patients provide higher infusion safety.
  • the support frame and the buckle structure are arranged such that the exhaust device and the chemical liquid filter film form a pre-made module, and the module pre-made by the liquid chemical filter film and the exhaust device is suspended in the sealed cavity body, and is buckled.
  • the structure is simply pressed into the sealed cavity to be fixedly installed, and the precision filtration infusion container can be assembled modularly to reduce the production cost.
  • FIG. 1 is a schematic view showing the entire structure of a first embodiment of the present invention
  • Figure 2 is a schematic view showing the overall structure of a second embodiment of the present invention.
  • FIG. 3 is a horizontal schematic view of the overall structure of the filter chamber according to an embodiment of the present invention.
  • the present invention is a precision filtration infusion container, comprising a container body 1 and a sealed cavity 2 separated from the container body 1 by a sealing device 6;
  • liquid chemical filtering device a liquid chemical filtering device, an exhaust device and a sealing rubber plug 3 are disposed in the sealed cavity 2;
  • the liquid filtering device comprises at least one liquid filtering membrane 4;
  • At least one of the liquid chemical filtration membranes 4 forms a filtrate chamber 5 around the exhaust device, and the filtrate chamber 5 is suspended in the sealing chamber 2;
  • the container body 1 is provided with an infusion puncture position.
  • the precision filtration infusion container separates the container body 1 and the sealing cavity 2 by the sealing device 6, and stores the chemical liquid in the container body 1 in a storage state or when not in use, so that the liquid medicine enters the sealing when needed.
  • the cavity 2 can be used to prevent the liquid filtration membrane 4 from being immersed in the chemical solution for a long time before use, resulting in a decrease in efficiency or even failure, and the infusion puncture is located in the filtrate chamber 5, and the drug solution is applied through the liquid filtration membrane 4 during the infusion process.
  • the liquid After the liquid is filtered, the liquid is infused through the infusion puncture position, and the liquid pressure on the liquid filtration membrane 4 is low, which can reduce or even avoid the passage of the particles of the critical pore size, thereby better ensuring the purity of the liquid, and the liquid filtration membrane 4 Only the particles of the bottle liquid are left on, the unintended reaction of different drug particles is avoided, and the non-pyrogen infusion reaction is reduced, thereby providing a higher infusion safety guarantee for the patient.
  • the inner cavity of the sealing chamber 2 is hollow cylindrical.
  • the sealing device 6 is a releasable sealing block 61 in which the main body is recessed and the outer portion is contracted to the distal end, and the distal end of the releasable sealing block 61 and the sealing cavity 2 are sealed.
  • the inner wall is connected, and a recessed activation lever 62 is connected to the concave portion of the releasable sealing block 61.
  • the releasable sealing block 61 is provided with a frangible portion 64 at the end of the inner wall of the sealing cavity 2, and an outer side of the toggle actuating lever 62 is provided with an operating ring 63.
  • the structure of the sealing device 6 has various implementation forms. When the filtering infusion container is put into use, the sealing device 6 can be opened by hand, so that the container body 1 and the sealing cavity 2 are sealed. The implementation of set 6 is within the scope of the present invention.
  • one end of the releasable sealing block 61 is connected to the inner wall of the sealing cavity 2 to separate the space inside the container body 1 and the sealing cavity 2, and by pulling the toggle enabling lever 62, Breaking the connection between the end of the releasable sealing block 61 and the inner wall of the sealing cavity 2, that is, breaking the frangible portion 64, so that the container body 1 communicates with the inner cavity of the sealing cavity 2, so that the liquid medicine enters the sealing cavity 2 .
  • the sealing device 6 is a sealing plate 65 that is placed across the sealing cavity 2, and at least one of the upper and lower sides of the sealing plate 65 is welded to the inner wall of the sealing cavity 2 by a weak weld.
  • the upper and lower sides of the sealing plate 65 are respectively welded to the inner wall of the sealing cavity 2 by a weak weld.
  • the sealing device 6 of the two sides is soldered in the sealing cavity 2, and the sealing device 6 is cleaned in the invention because of the mature processing process, the quick separation process and the few particles generated.
  • the form of the virtual welding between the single side and the inner wall of the sealing cavity 2 is insufficient to ensure the safety during the transportation of the filtering infusion container, so that the side welding is performed on both sides of the sealing device 6, so that the container can be better protected.
  • the isolation performance between the body 1 and the sealing cavity 2 ensures better safety during transportation.
  • the outer wall of the sealing cavity 2 on the infusion container is squeezed by hand, and the virtual welded joint between the sealing cavity 2 and the sealing device 6 is broken, thereby breaking the sealing device 6, so that the container body 1 and the sealing The chambers 2 are in communication.
  • Destroying the form of the sealing device 6 by pushing the lever or pulling the lever can make the sealing
  • the destruction of the device 6 has a higher success rate, which ensures that the infusion container is quickly put into use in an emergency.
  • the medical liquid filtering device includes at least one medical liquid filtration membrane 4.
  • the medical liquid filtration membrane is a hollow cylindrical shape or a hollow cylinder provided with an opening.
  • the block-shaped chemical liquid filtration membrane can also be surrounded by a cylindrical shape.
  • At least one of the medical liquid filtration membranes 4 surrounds the filtrate chamber 5 with the exhaust device.
  • At least one side wall of the filtrate chamber 5 forms an infusion puncture site.
  • the filtrate chamber 5 is provided with a support frame for keeping the filtrate chamber 5 in a hollow state.
  • the inner wall of the sealing cavity 2 is provided with a snap structure for fixing the support frame.
  • At least one of the liquid chemical filtration membranes 4 forms a filtrate chamber 5 around the exhaust device, and the filtrate chamber 5 is suspended in the sealed chamber 2, and one side wall of the filtrate chamber 5 The infusion puncture site is formed.
  • At least one of the liquid chemical filtration membranes 4 forms a filtrate chamber 5 around the exhaust device, and the filtrate chamber 5 is suspended in the sealing cavity 2 by a fastening structure of the fixed support frame.
  • One side wall of the filtrate chamber 5 forms an infusion puncture site.
  • At least one of the liquid chemical filtration membranes 4 surrounds
  • the venting means forms a filtrate chamber 5 which is suspended in the sealing chamber 2 by a support frame.
  • the support frame and the buckle structure are arranged such that the exhaust device and the chemical liquid filter film 4 form a pre-made module, and the module pre-made by the liquid chemical filter film 4 and the exhaust device is suspended in the sealed cavity 2 It can be fixedly installed by simply pressing the buckle structure into the sealing cavity, and the precision filtration infusion container can be assembled modularly to reduce the production cost.
  • a closed rubber block 8 is provided at the bottom of the filtrate chamber 5.
  • the arrangement of the sealing block 8 can form an infusion puncture position to facilitate the penetration of the puncture needle into the filtrate chamber while avoiding leakage around the puncture needle.
  • At least one of the liquid chemical filtration membranes 4 forms a filtrate chamber 5 around the exhaust device, and a bottom portion of the filtrate chamber 5 is provided with a sealing rubber block 8 which is suspended by a support frame. Sealed inside the cavity 2.
  • At least one of the liquid chemical filtration membranes forms a filtrate chamber around the exhaust device, and a bottom of the filtrate chamber is provided with a sealing rubber block 8 suspended in the sealed cavity, the sealing The glue block 8 forms an infusion puncture position.
  • At least one of the liquid chemical filter membranes forms a filtrate chamber around the exhaust device, and a bottom of the filtrate chamber is provided with a sealing rubber block 8 which is suspended by a snap structure of the fixed support frame. In the sealed cavity, the sealing block 8 forms an infusion puncture site.
  • the infusion puncture needle first enters the sealed cavity 2 through the infusion puncture position on the closed rubber stopper 3, and then enters the filtrate chamber 5 through the infusion puncture position on the sealed rubber block 8.
  • the drug solution needs to enter the filtrate chamber 5 before being input into the patient through the infusion puncture position, and the drug solution passes through the filtrate chamber 5
  • the chemical liquid filtration membrane 4 enters the filtrate chamber 5, that is, the chemical liquid must be filtered through the filtration of the chemical liquid filtration membrane 4 to achieve the effect of filtering the chemical liquid during the infusion.
  • the top end of the filtrate chamber 5 is provided with an exhaust device.
  • the top end of the filtrate chamber 5 is provided with an exhaust device; the exhaust device is a horizontally disposed gas permeable membrane, or the exhaust device includes a horizontally disposed exhaust passage and is located An exhaust valve in the exhaust passage.
  • the exhaust device located at the top of the filtrate chamber 5 is used for discharging the gas in the liquid medicine or entering the sealed chamber 2 into the container body 1. Before the infusion, the gas in the filtrate chamber 5 is discharged to avoid the gas in the infusion container entering the infusion container.
  • the infusion line at the same time, balances the air pressure in the container body 1 and the sealed chamber 2.
  • the exhaust device located at the top of the gas filter 8 is for discharging the gas entering from the outside, and the exhaust device at the top of the filtrate chamber 5 is for discharging the gas in the chemical liquid or entering the sealed cavity 2 into the container body 1, The purity of the liquid in the sealed cavity 2 is ensured, and at the same time, the air pressure in the container body 1 and the sealed cavity 2 can be balanced.
  • the venting means is a horizontally disposed gas permeable membrane.
  • the gas permeable membrane is a water-permeable gas permeable membrane, which prevents the chemical liquid in the container body 1 from directly entering the sealing cavity 2 through the gas permeable membrane, but allows the gas in the sealing cavity 2 to enter the container body 1 through the gas permeable membrane.
  • the exhaust device includes a horizontally disposed exhaust passage and an exhaust valve located within the exhaust passage.
  • the exhaust passage includes at least one inner cavity concave A long groove is provided, and the exhaust valve is a cylindrical rod or a spherical valve located in the exhaust passage.
  • the filter infusion container as a whole When the container body 1 is suspended, the filter infusion container as a whole is inverted, and the sealed cavity 2 is located below the container body 1, and the gas in the sealed cavity 2 escapes upward into the container body 1.
  • the cylindrical rod or the spherical valve forms a seal downwardly and the long grooves closely contacting the two sides, preventing the liquid medicine from entering the sealed cavity 2 through the gap of the long groove.
  • the liquid filtration membrane 4 on both sides of the exhaust passage is arched, and the highest point of the arch is the position of the exhaust passage.
  • a chemical liquid filtration membrane 4 is provided around the exhaust device, and the periphery of the chemical liquid filtration membrane 4 is hermetically connected to the inner wall of the sealed chamber 2.
  • the chemical liquid filtration membrane splicing portion, the liquid chemical filtration membrane and the exhaust device of each layer, the liquid chemical filtration membrane and the exhaust device of each layer, and the sealing rubber block are disposed between the layers.
  • the container body 1 is provided with an infusion puncture position.
  • the sealing cavity 2 is provided with a sealing rubber plug 3.
  • the bottom of the sealing cavity 2 is a releasable sealing cover 7, and a loopable portion 64 is provided around the releasable sealing cover 7, and the bottom of the releasable sealing cover 7 is provided.
  • a ring of snap rings disposed parallel to the releasable sealing cover 7 is disposed in the sealing cavity 2, and the sealing rubber plug 3 is locked between the releasable sealing cover 7 and the snap ring.
  • the releasable sealing cover 7 is provided with a ring of protrusions on the outer periphery of the frangible portion 64 which is equal to the inner diameter of the snap ring. After the frangible portion 64 is broken by the open cavity pull ring 71, the sealing rubber plug 3 passes through the cards on both sides. The ring and the releasable sealing cover are fixed and fixed.
  • the position of the corresponding filtrate chamber 5 on the closed rubber plug 3 is the infusion puncture position, and other areas in the sealed rubber plug 3 avoiding the position of the filtrate chamber 5 and the gas filter 8 can be used as a liquid medicine to supplement the puncture position, and need to be filtered.
  • the puncture liquid can be supplemented by the puncture liquid to complete the supplementary addition of the liquid medicine.
  • the inner cavity of the container body 1 and the sealing cavity 2 are both columnar structures, and the cross-sectional diameter of the container body 1 is larger than the cross-sectional diameter of the sealing cavity 2.
  • the top of the container body 1 is provided with a lifting eye for hanging.

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
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  • Engineering & Computer Science (AREA)
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Abstract

一种精密过滤输液容器，包括容器本体（1）及通过密封装置（6）与容器本体（1）分隔开来的密封腔体（2）；所述密封腔体（2）内设有药液过滤装置、排气装置和密闭胶塞（3）；所述药液过滤装置包括至少一道药液过滤膜（4）；至少一道所述药液过滤膜（4）围绕与排气装置形成滤液腔（5），所述滤液腔（5）悬置于密封腔体（2）内；所述容器本体（1）上设有输液穿刺位。此输液容器能降低生产成本，保障输液安全。

Description

一种精密过滤输液容器 技术领域
本发明涉及医药包装材料领域，特别是涉及一种精密过滤输液容器。
背景技术
在传统治疗手段中，输液治疗是其中一个重要的方式。但输液中存在大量不溶性微粒，其中因药物溶解不充分导致的不溶性微粒占据主要部分。
传统输液容器只提供盛存药液的作用，不能将药液中不溶性微粒过滤。
现阶段临床以应用过滤输液器来解决输液中的微粒问题，普通的过滤输液器因过滤膜与输液容器有一定的高度差，液体压力较大，导致部份临界滤孔大小的微粒亦会通过过滤膜进入人体。临床上亦会出现同一根输液器上需进行多组药物、长时间输注的情况。在非热原输液反应中，药液中微粒数的超标是引起反应的重要因素，而输液过程时使用的输液器，由于较长时间的使用使其滤器的过滤作用大大减弱或丧失，甚至成为一个增加微粒的污染源。同时，不同的药物颗粒会停留在滤网上，增加相互反应的风险。
有应用过滤装置的输液容器，因滤液腔内气体不能在输液前排出，导致滤液腔内气体会随输液穿刺针进入输液管道，不符合临床安全应用要求。
现行精密过滤输液容器需将各个组件多次粘接、组装，增加工序，增加成本，增加病人医疗费用。
发明内容
为解决上述问题，本发明提供一种可过滤注射液中的不溶性颗粒和解决滤液腔内气体在输液前排出问题并可降低生产成本的精密过滤输液容器。
本发明解决其技术问题所采用的技术方案是：
一种精密过滤输液容器，包括容器本体及通过密封装置与容器本体分隔开来的密封腔体；
所述密封腔体内设有药液过滤装置、排气装置和密闭胶塞；所述药液过滤装置包括至少一道药液过滤膜；
至少一道所述药液过滤膜围绕与排气装置形成滤液腔，所述滤液腔悬置于密封腔体内；
所述容器本体上设有输液穿刺位。
进一步作为本发明技术方案的改进，密封腔体的内腔为中空圆柱形。
进一步作为本发明技术方案的改进，密封装置为一主体内部凹陷且外部向远端收缩为尖端的可松脱密封块，所述可松脱密封块外部的远端顶点与密封腔体内壁相连，所述可松脱密封块的内凹部分连接有一拨动启用杆，可松脱密封块与密封腔体内壁相连处设有易裂部，所述拨动启用杆的外侧设有一操作环。
进一步作为本发明技术方案的改进，密封装置为一主体内部凹陷 且外部向远端收缩为尖端的可松脱密封块，所述可松脱密封块外部的远端顶点与密封腔体内壁相连，所述可松脱密封块的内凹部分连接有一拨动启用杆。
进一步作为本发明技术方案的改进，可松脱密封块与密封腔体内壁相连处设有易裂部，所述拨动启用杆的外侧设有一操作环。
进一步作为本发明技术方案的改进，密封装置为横置于密封腔体内的密封板，所述密封板的上下侧边分别与密封腔体内壁间进行虚焊密封。
进一步作为本发明技术方案的改进，所述药液过滤装置包括至少一道药液过滤膜。
进一步作为本发明技术方案的改进，所述药液过滤膜为中空圆柱形或设有开口的中空圆柱体。
进一步作为本发明技术方案的改进，滤液腔的顶端设有排气装置。
进一步作为本发明技术方案的改进，所述滤液腔的顶端设有排气装置；所述排气装置为一层水平设置的透气膜，或者所述排气装置包括水平设置的排气通道和位于所述排气通道内的排气阀门。
进一步作为本发明技术方案的改进，至少一道所述药液过滤膜围绕与排气装置形成滤液腔。
进一步作为本发明技术方案的改进，所述滤液腔的至少一个侧壁为输液穿刺位。
进一步作为本发明技术方案的改进，所述滤液腔上设有用于保持 滤液腔呈中空状态的支撑架。
进一步作为本发明技术方案的改进，所述密封腔体内壁设有用于固定支撑架的卡扣结构。
进一步作为本发明技术方案的改进，至少一道所述药液过滤膜围绕与排气装置形成滤液腔，所述滤液腔悬置于密封腔体内，所述滤液腔的一个侧壁形成输液穿刺位。
进一步作为本发明技术方案的改进，至少一道所述药液过滤膜围绕与排气装置形成滤液腔，所述滤液腔通过固定支撑架的卡扣结构悬置于密封腔体内，所述滤液腔的一个侧壁形成输液穿刺位。
进一步作为本发明技术方案的改进，滤液腔的底部设有密闭胶块。
进一步作为本发明技术方案的改进，至少一道所述药液过滤膜围绕与排气装置形成滤液腔，滤液腔的底部设有密闭胶块，所述滤液腔悬置于密封腔体内。
进一步作为本发明技术方案的改进，至少一道所述药液过滤膜围绕与排气装置形成滤液腔，滤液腔的底部设有密闭胶块，所述滤液腔通过固定支撑架的卡扣结构悬置于密封腔体内，所述密闭胶块形成输液穿刺位。
进一步作为本发明技术方案的改进，排气装置为一层水平设置的透气膜。
进一步作为本发明技术方案的改进，排气装置包括水平设置的排气通道和位于所述排气通道内的排气阀门。
进一步作为本发明技术方案的改进，排气通道包括至少一侧内腔内凹形设置的长槽，所述排气阀门为位于排气通道内的圆柱形杆或者球形阀。
进一步作为本发明技术方案的改进，排气装置的四周设有药液过滤膜，所述药液过滤膜的四周均与密封腔体内壁密闭连接。
进一步作为本发明技术方案的改进，所述药液过滤膜拼接处、各层所述药液过滤膜与排气装置间、各层所述药液过滤膜与排气装置以及密闭胶块间设有保证水密性的密封装置。
进一步作为本发明技术方案的改进，所述密封腔体上设有密闭胶塞。
进一步作为本发明技术方案的改进，所述容器本体上设有输液穿刺位。
进一步作为本发明技术方案的改进，所述容器本体上设有药液补充穿刺位。
进一步作为本发明技术方案的改进，密封腔体的底部为可松脱密闭盖，环绕所述可松脱密闭盖设有一圈易裂部，所述可松脱密闭盖的底部设有开腔拉环。
进一步作为本发明技术方案的改进，密封腔体内设有平行于可松脱密闭盖设置的一圈卡环，所述密闭胶塞卡固在可松脱密闭盖与卡环之间。
进一步作为本发明技术方案的改进，容器本体和密封腔体的内腔均为柱状结构，所述容器本体的横截面直径大于密封腔体的横截面直 径。
进一步作为本发明技术方案的改进，容器本体的顶部设有用于悬挂的吊环。
本发明的有益效果：此精密过滤输液容器通过密封装置将容器本体和密封腔体分隔开来，在储存状态或者未使用时将药液隔离储存在容器本体内，在需要使用时使得药液进入密封腔体即可，且输液穿刺位在滤液腔内，输液过程中通过药液过滤膜对药液进行过滤后通过输液穿刺位进行输液，可更好的保障药液的纯净程度，从而对患者提供更高的输液安全保障。
支撑架和卡扣结构的设置可以使排气装置、药液过滤膜形成一个预制作的模块，由药液过滤膜与排气装置预制作而成的模块悬空设置于密封腔体内，通过卡扣结构简单压入密封腔体即可固定安装，可以模块化组装精密过滤输液容器，降低生产成本。
附图说明
下面结合附图对本发明作进一步说明：
图1是本发明中第一实施例整体结构示意图；
图2是本发明中第二实施例整体结构示意图；
图3是本发明实施例经过滤腔整体结构水平示意图。
具体实施方式
参照图1～图3，本发明为一种精密过滤输液容器，包括容器本体1及通过密封装置6与容器本体1分隔开来的密封腔体2；
所述密封腔体2内设有药液过滤装置、排气装置和密闭胶塞3；所述 药液过滤装置包括至少一道药液过滤膜4；
至少一道所述药液过滤膜4围绕与排气装置形成滤液腔5，所述滤液腔5悬置于密封腔体2内；
所述容器本体1上设有输液穿刺位。
此精密过滤输液容器通过密封装置6将容器本体1和密封腔体2分隔开来，在储存状态或者未使用时将药液隔离储存在容器本体1内，在需要使用时使得药液进入密封腔体2即可，避免药液过滤膜4在使用前长时间浸泡在药液中而导致效能降低甚至失效，且输液穿刺位在滤液腔5内，输液过程中通过药液过滤膜4对药液进行过滤后通过输液穿刺位进行输液，药液过滤膜4上的液体压力低，可减少甚至避免临界滤孔大小的微粒通过，可更好的保障药液的纯净程度，药液过滤膜4上仅存留该瓶药液的微粒，避免不同药物微粒发生非预期反应，减少非热原输液反应，从而对患者提供更高的输液安全保障。
作为本发明优选的实施方式，密封腔体2的内腔为中空圆柱形。
作为本发明优选的实施方式，密封装置6为一主体内部凹陷且外部向远端收缩为尖端的可松脱密封块61，所述可松脱密封块61外部的远端顶点与密封腔体2内壁相连，所述可松脱密封块61的内凹部分连接有一拨动启用杆62。
作为本发明优选的实施方式，可松脱密封块61与密封腔体2内壁相连处设有易裂部64，所述拨动启用杆62的外侧设有一操作环63。密封装置6的结构有多种实现形式，在该过滤输液容器投入使用时，可徒手打开密封装置6，使得容器本体1与密封腔体2相通的密封装 置6的实现形式均在本发明的保护范围内。
在密封装置6的第一种实现形式中，可松脱密封块61的一端与密封腔体2的内壁相连来分隔容器本体1与密封腔体2内空间，通过拉动拨动启用杆62，可破坏可松脱密封块61的端头与密封腔体2内壁间的连接，即破坏易裂部64，使得容器本体1与密封腔体2的内腔相通，从而药液进入密封腔体2内。
作为本发明优选的实施方式，密封装置6为横置于密封腔体2内的密封板65，密封板65的上下两侧至少有一侧与密封腔体2的内壁进行虚焊密封。
作为实施方式的优选，密封板65的上下侧边分别与密封腔体2内壁间进行虚焊密封。
作为密封装置6的第二种实现形式，两侧面虚焊在密封腔体2内的密封装置6的设置形式，因其加工工艺成熟、分离过程快捷且产生的微粒极少，是本发明中密封装置6的最优选实施方式。
单独一侧面与密封腔体2内壁间虚焊固定的形式不足以保证过滤输液容器运输过程中的安全性，故在密封装置6的两侧侧面均进行虚焊，从而可在更好的保障容器本体1与密封腔体2间隔离性能的同时，更好的保障运输过程中的安全性。
在过滤输液容器使用前，徒手挤压过滤输液容器上密封腔体2的外壁，破坏密封腔体2与密封装置6之间的虚焊连接，即可破坏密封装置6，使得容器本体1与密封腔体2相通。
通过推动杆或者拉动杆来破坏密封装置6的形式，能使得对密封 装置6的破坏具有更高的成功率，能保证在紧急情况下，过滤输液容器的快速投入使用。
作为本发明优选的实施方式，所述药液过滤装置包括至少一道药液过滤膜4。
作为本发明优选的实施方式，所述药液过滤膜为中空圆柱状或者为设有开口的中空圆柱体。特别的，也可将块状的药液过滤膜围绕成圆柱状。
作为本发明优选的实施方式，至少一道所述药液过滤膜4围绕与排气装置形成滤液腔5。
作为本发明优选的实施方式，所述滤液腔5的至少一个侧壁形成输液穿刺位。
作为本发明优选的实施方式，所述滤液腔5上设有用于保持滤液腔5呈中空状态的支撑架。
作为本发明优选的实施方式，所述密封腔体2内壁设有用于固定支撑架的卡扣结构。
作为本发明优选的实施方式，至少一道所述药液过滤膜4围绕与排气装置形成滤液腔5，所述滤液腔5悬置于密封腔体2内，所述滤液腔5的一个侧壁形成输液穿刺位。
作为本发明优选的实施方式，至少一道所述药液过滤膜4围绕与排气装置形成滤液腔5，所述滤液腔5通过固定支撑架的卡扣结构悬置于密封腔体2内，所述滤液腔5的一个侧壁形成输液穿刺位。
作为本发明优选的实施方式，至少一道所述药液过滤膜4围绕与 排气装置形成滤液腔5，所述滤液腔5通过支撑架悬置于密封腔体2内。
支撑架和卡扣结构的设置可以使排气装置、药液过滤膜4形成一个预制作的模块，由药液过滤膜4与排气装置预制作而成的模块悬空设置于密封腔体2内，通过卡扣结构简单压入密封腔体即可固定安装，可以模块化组装精密过滤输液容器，降低生产成本。
作为本发明优选的实施方式，滤液腔5的底部设有密闭胶块8。密闭胶块8的设置可形成输液穿刺位便于穿刺针进入滤液腔，同时避免穿刺针周边形成泄漏。
作为本发明优选的实施方式，至少一道所述药液过滤膜4围绕与排气装置形成滤液腔5，滤液腔5的底部设有密闭胶块8，所述滤液腔5通过支撑架悬置于密封腔体2内。
作为本发明优选的实施方式，至少一道所述药液过滤膜围绕与排气装置形成滤液腔，滤液腔的底部设有密闭胶块8，所述滤液腔悬置于密封腔体内，所述密闭胶块8形成输液穿刺位。
作为本发明优选的实施方式，至少一道所述药液过滤膜围绕与排气装置形成滤液腔，滤液腔的底部设有密闭胶块8，所述滤液腔通过固定支撑架的卡扣结构悬置于密封腔体内，所述密闭胶块8形成输液穿刺位。
输液穿刺针先通过密闭胶塞3上输液穿刺位进入密封腔体2，再通过密闭胶块8上输液穿刺位进入滤液腔5。药液在通过输液穿刺位输入进入患者体内前，需进入滤液腔5内，药液通过环绕滤液腔5的 药液过滤膜4进入滤液腔5，即药液必须经过药液过滤膜4的过滤方可输出，达到输液时药液过滤的效果。
作为本发明优选的实施方式，滤液腔5的顶端设有排气装置。
作为本发明优选的实施方式，所述滤液腔5的顶端设有排气装置；所述排气装置为一层水平设置的透气膜，或者所述排气装置包括水平设置的排气通道和位于所述排气通道内的排气阀门。
位于滤液腔5顶端的排气装置用于排出药液中或者进入密封腔体2内的气体至容器本体1内，输液前排出滤液腔5内气体，避免输液时输液容器内气体随穿刺针进入输液管路，同时，可平衡容器本体1和密封腔体2内的气压。
位于气体过滤器8顶部的排气装置用于排出由外界进入的气体，而位于滤液腔5顶端的排气装置用于排出药液中或者进入密封腔体2内的气体至容器本体1内，保证密封腔体2内药液的纯净度，同时，可平衡容器本体1和密封腔体2内的气压。
作为本发明优选的实施方式，排气装置为一层水平设置的透气膜。
优选的，透气膜为隔水透气膜，可防止容器本体1内的药液通过透气膜直接进入密封腔体2内，但能允许密封腔体2内的气体通过透气膜进入容器本体1内。
作为本发明优选的实施方式，排气装置包括水平设置的排气通道和位于所述排气通道内的排气阀门。
作为本发明优选的实施方式，排气通道包括至少一侧内腔内凹形 设置的长槽，所述排气阀门为位于排气通道内的圆柱形杆或者球形阀。
容器本体1通过悬吊使用时，过滤输液容器整体呈倒置形势，密封腔体2位于容器本体1的下方，密封腔体2内的气体向上逸出至容器本体1内。
正常状态下，圆柱形杆或者球形阀向下和紧贴两侧的长槽形成密封，防止药液通过长槽的空隙进入密封腔体2内。
排气通道两侧的药液过滤膜4呈拱形设置，拱形的最高点即为排气通道所在位置，当密封腔体2内的气体向上逸出至一定量时，托住圆柱形杆或者球形阀向上移动，打开排气通道，则气体可通过排气通道逸出至容器本体1内。
作为本发明优选的实施方式，排气装置的四周设有药液过滤膜4，所述药液过滤膜4的四周均与密封腔体2内壁密闭连接。
作为本发明优选的实施方式，所述药液过滤膜拼接处、各层所述药液过滤膜与排气装置间、各层所述药液过滤膜与排气装置以及密闭胶块间设有保证水密性的密封装置。
作为本发明优选的实施方式，所述容器本体1上设有输液穿刺位。
作为本发明优选的实施方式，所述密封腔体2上设有密闭胶塞3。
作为本发明优选的实施方式，密封腔体2的底部为可松脱密闭盖7，环绕所述可松脱密闭盖7设有一圈易裂部64，所述可松脱密闭盖7的底部设有开腔拉环71。
作为本发明优选的实施方式，密封腔体2内设有平行于可松脱密闭盖7设置的一圈卡环，所述密闭胶塞3卡固在可松脱密闭盖7与卡环之间。
可松脱密闭盖7上在易裂部64的外围设有与卡环内径相等的一圈凸起，在通过开腔拉环71破坏易裂部64后，密闭胶塞3即通过两侧的卡环和可松脱密闭盖外围卡固进行固定。
密闭胶塞3上对应滤液腔5位置即为输液穿刺位，在密闭胶塞3上避开滤液腔5和气体过滤器8所在位置的其他区域均可作为药液补充穿刺位，在需要向过滤输液容器内补充药液时，通过穿刺药液补充穿刺位，即可完成药液的补充添加。
作为本发明优选的实施方式，容器本体1和密封腔体2的内腔均为柱状结构，所述容器本体1的横截面直径大于密封腔体2的横截面直径。
作为本发明优选的实施方式，容器本体1的顶部设有用于悬挂的吊环。
当然，本发明创造并不局限于上述实施方式，熟悉本领域的技术人员在不违背本发明精神的前提下还可作出等同变形或替换，这些等同的变型或替换均包含在本申请权利要求所限定的范围内。

Claims (10)

  1. 一种精密过滤输液容器，包括容器本体及通过密封装置与容器本体分隔开来的密封腔体；所述密封腔体内设有药液过滤装置、排气装置和密闭胶塞；所述药液过滤装置包括至少一道药液过滤膜；至少一道所述药液过滤膜围绕与排气装置形成滤液腔，所述滤液腔悬置于密封腔体内；所述容器本体上设有输液穿刺位。
  2. 根据权利要求1所述的精密过滤输液容器，其特征在于：所述密封装置为一主体内部凹陷且外部向远端收缩为尖端的可松脱密封块，所述可松脱密封块外部的远端顶点与密封腔体内壁相连，所述可松脱密封块的内凹部分连接有一拨动启用杆，所述可松脱密封块与密封腔体内壁相连处设有易裂部，所述拨动启用杆的外侧设有一操作环。
  3. 根据权利要求1所述的精密过滤输液容器，其特征在于：所述滤液腔的底部设有密闭胶块。
  4. 根据权利要求1所述的精密过滤输液容器，其特征在于：所述滤液腔上设有用于保持滤液腔呈中空状态的支撑架。
  5. 根据权利要求1所述的精密过滤输液容器，其特征在于：所述密封腔体内壁设有用于固定支撑架的卡扣结构。
  6. 根据权利要求1所述的精密过滤输液容器，其特征在于：至少一道所述药液过滤膜围绕与排气装置形成滤液腔，所述滤液腔悬置于密封腔体内，所述滤液腔的一个侧壁形成输液穿刺位。
  7. 根据权利要求1所述的精密过滤输液容器，其特征在于：至少一 道所述药液过滤膜围绕与排气装置形成滤液腔，所述滤液腔通过固定支撑架的卡扣结构悬置于密封腔体内，所述滤液腔的一个侧壁形成输液穿刺位。
  8. 根据权利要求1所述的精密过滤输液容器，其特征在于：至少一道所述药液过滤膜围绕与排气装置形成滤液腔，滤液腔的底部设有密闭胶块，所述滤液腔悬置于密封腔体内。
  9. 根据权利要求1所述的精密过滤输液容器，其特征在于：至少一道所述药液过滤膜围绕与排气装置形成滤液腔，滤液腔的底部设有密闭胶块，所述滤液腔通过固定支撑架的卡扣结构悬置于密封腔体内，所述密闭胶块形成输液穿刺位。
  10. 根据权利要求1所述的精密过滤输液容器，其特征在于：所述药液过滤膜拼接处、各层所述药液过滤膜与排气装置间、各层所述药液过滤膜与排气装置以及密闭胶块间设有保证水密性的密封装置。
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