WO2017054857A1 - Procédé et ensemble destinés à l'analyse d'haleine, l'analyse étant effectuée non seulement sur un gaz expiré mais aussi sur un condensat d'haleine - Google Patents

Procédé et ensemble destinés à l'analyse d'haleine, l'analyse étant effectuée non seulement sur un gaz expiré mais aussi sur un condensat d'haleine Download PDF

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Publication number
WO2017054857A1
WO2017054857A1 PCT/EP2015/072575 EP2015072575W WO2017054857A1 WO 2017054857 A1 WO2017054857 A1 WO 2017054857A1 EP 2015072575 W EP2015072575 W EP 2015072575W WO 2017054857 A1 WO2017054857 A1 WO 2017054857A1
Authority
WO
WIPO (PCT)
Prior art keywords
breath
humid
receiving
analysis according
sample
Prior art date
Application number
PCT/EP2015/072575
Other languages
German (de)
English (en)
Inventor
Maximilian Fleischer
Andreas Kappel
Erhard Magori
Roland Pohle
Kerstin Wiesner
Oliver von Sicard
Original Assignee
Siemens Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Aktiengesellschaft filed Critical Siemens Aktiengesellschaft
Priority to PCT/EP2015/072575 priority Critical patent/WO2017054857A1/fr
Publication of WO2017054857A1 publication Critical patent/WO2017054857A1/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath

Definitions

  • the present invention relates to an arrangement for breathing ⁇ gas analysis according to the preamble of claim 1.
  • the present invention relates to a method for breathing gas analysis according to the preamble of claim 12.
  • VOCs Metabolites that humans did not produce themselves. Rather, these are due to VOCs, which started through the lungs (outside air), skin (outside air, external Substan ⁇ zen like, for example, ointments and creams), digestive gas tract (food, drugs, tobacco) or other physiological interfaces man and those with whom the body has saturated so that it stores and metabolizes them.
  • the inventive arrangement for breath analysis is designed such that a humid breath sample from a subject the ⁇ art to a device for evaluation of ingredients of a respiratory gas, in particular a Atemsampier is supplied, that these evaluating means at least parts of Ingredients of a breath condensate and at least parts of the ingredients breath gas of the breath sample determined.
  • the method according to the invention enables an accurate analysis of the constituents of the breath of a subject, since both volatile organic substances (VOCs) contained in the respiratory gas and nonvolatile and / or semi-volatile substances contained in the respiratory condensate, so-called Exhaled Breath
  • the inventive arrangement for Atemana ⁇ analysis it is further formed such that the feeder is designed such that a device for receiving the hu ⁇ miden breath sample disposed and is operatively connectable that existing moist breath units may condense in such a way in the housing that they in particular for one of the Zu ⁇ management of Ausellessaussch prior treatment by a manipulation device is stored.
  • the arrangement according to the invention for breathing analysis is developed so that the device for receiving the humid breath sample, such configured and funk ⁇ tionally connected to the evaluation device that the non-condensed in the recording residual breath portions of the feed to the evaluation orientation preceding drying are subjected ,
  • a condensing speeds can cause the further training of the arrangement according to the invention for breath analysis according to the means for receiving the humid breath sample, is designed such that it cools the respiratory gas sample at least from ⁇ cut of the receiving device, make a significant contribution. In addition, this can also lead to a complete drying of the remaining respiratory gas, since cooling can also be used in such a way to withdraw liquid. It is also conceivable freezing of the moist portions of the humid breath sample, so that in principle abruptly the moist ⁇ te is separated from the breathing gas.
  • the arrangement for breath analysis can be such further formed before ⁇ geous, that the device for on ⁇ acquisition of the humid breath sample is so designed with a cooling means that the cooling to a condensation ensuring end, particularly in a ⁇ finally 4 ° C up to and including -20 ° C, temperature is.
  • a cooling device can be designed such that, only a certain Tempe ⁇ raturwert is permanently canceled.
  • a ⁇ a freely selectable position over at least a temperature range, in particular the above-mentioned range, it is also conceivable in this development. It has the advantage of being flexible with regard to the desired type of stored sample of condensate.
  • the device for receiving the humid breath sample is designed such that an arrangement for cooling the sections of the receiving device is designed and functionally connected in such a way that cooling takes place Basis of ice, salt and water based liquid ice, liquid nitrogen and / or electrical cooling, in particular mediated by a cooling hose and / or a cooling sleeve occurs.
  • the invention is putge ⁇ forms that the means for receiving the humid breath sample, such configured and connectable to the evaluation device, that the supply takes place in such a way that gases of the gas space of the condensed Atemgasanteile be recorded controlled. Controlled recording allows the more exact
  • the arrangement is advantageously further developed such that the manipulation device is configured and functionally connectable to the evaluation device such that the stored condensed components are heated and / or vaporized and the heated and / or vaporized components are supplied to the evaluation device.
  • the time of recording by the analysis device controlled be, because by the start of the heating and the contents ⁇ the time of the presence of analyzable Wars ⁇ materials is determined.
  • only certain ingredients can be isolated by the analyzing means are supplied ⁇ performs the evaporation / vaporization temperature of ingredients where appropriate by adjusting certain temperatures.
  • the means for receiving the humid breath sample such out is ⁇ staltet that to control recording of the gases takes place at least partially by adjusting ⁇ a dedicated temperature.
  • At least parts of Einrich ⁇ tung are configured for receiving the humid breath sample, that they can be at least partially subjected to a rinse, so that the following samples are not corrupted Kgs ⁇ nen and / or in the medical environment necessary hygiene is ensured.
  • the invention further relates to a method for breath analysis in which a recording of a humid breath sample of a test person is supplied to a device for evaluating constituents of a breathing gas, in particular breath sampler, that this evaluation device at least parts of the In retaining materials of a breath condensate and at least parts of determined In ⁇ holding materials breathable gas of the breath sample.
  • FIG. 1 shows the schematic diagram of FIG an off ⁇ guide die of the inventive arrangement as well as an exemplary form of the procedure of the invention, that the process.
  • FIG. 1 shows a respiratory analysis system AS. He ⁇ know an arrangement for receiving the humid breath AE is shown according to the invention. It can be seen that in the illustrated embodiment, in order is a multiple-Seg ⁇ elements arrangement, which transition from an input (in the illustrated schematically mouth of a subject) to a output at which an analysis device sensor is arranged, wherein which may be a breath tester.
  • this breath tester can be made of Although this sensor is generally less accurate than other methods, this inaccuracies can be compensated for by the arrangement according to the invention. This also has the advantage that it is in such an array is a very günsti ⁇ ge of analysis.
  • these sensors are used for both SENSOR In ⁇ retaining materials of the respiratory gas, so the dry portion of a breath sample, as used for ingredients of an exhaled breath condensate, so condensed moist play a breath sample.
  • the invention however, a very extensive inde- mutually orthogonal marker of the condensate, and markers of the respiratory gas for analysis dependence achieved by these EBC analysis means and methods, as it allows facilezu provide ⁇ and so an accurate respiratory gas analysis solely by means of the respiratory gas analysis device AE and based thereon To enable diagnosis.
  • a first segment of the recording device AE shown in the FIGURE is a cooling section KM section shown in section, which in a first step S1, following an exhalation, cools the breath sample so that the moist portions of the breath sample are condensed to collect this section.
  • a cooling section KM section shown in section, which in a first step S1, following an exhalation, cools the breath sample so that the moist portions of the breath sample are condensed to collect this section.
  • this Ab ⁇ section is shown running diagonally to a vessel SP. This is intended to schematically collect and concentrate
  • a fifth step S5 the stored condensate is then heated by a heater H so that subsequently in a sixth step S6 also the Atemgas analyses worn, optionally also dried by the dryer ⁇ device TR, and fed in a seventh step S7 Respiratory gas analysis be supplied by the analyzer AE.
  • Analysis of the respiratory gas in the fourth step S4 are used for an exact ⁇ ren determination of relevant markers. For an accurate diagnosis possible. As can be seen in the illustration can be shown in the
  • the individual temperature-changing units KM, H and the respiratory analyzer AE are controlled by a processor ⁇ .
  • the cooling device KM can vary in the design of the type of cooling. For example, if the vomit ⁇ -assured condensate is to be held in liquid form, but rather in solid or a mixed form.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

L'invention concerne un ensemble pour l'analyse d'haleine, qui est conçu de sorte qu'un échantillon d'haleine humide prélevé sur un sujet est amené à un dispositif destiné à évaluer des constituants d'un gaz expiré, en particulier par l'intermédiaire d'un échantillonneur d'haleine, de sorte que ce dispositif d'évaluation détermine au moins des parties des constituants d'un condensat d'haleine et au moins des parties des constituants du gaz expiré de l'échantillon d'haleine. L'invention concerne en outre un procédé correspondant.
PCT/EP2015/072575 2015-09-30 2015-09-30 Procédé et ensemble destinés à l'analyse d'haleine, l'analyse étant effectuée non seulement sur un gaz expiré mais aussi sur un condensat d'haleine WO2017054857A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/EP2015/072575 WO2017054857A1 (fr) 2015-09-30 2015-09-30 Procédé et ensemble destinés à l'analyse d'haleine, l'analyse étant effectuée non seulement sur un gaz expiré mais aussi sur un condensat d'haleine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2015/072575 WO2017054857A1 (fr) 2015-09-30 2015-09-30 Procédé et ensemble destinés à l'analyse d'haleine, l'analyse étant effectuée non seulement sur un gaz expiré mais aussi sur un condensat d'haleine

Publications (1)

Publication Number Publication Date
WO2017054857A1 true WO2017054857A1 (fr) 2017-04-06

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Family Applications (1)

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PCT/EP2015/072575 WO2017054857A1 (fr) 2015-09-30 2015-09-30 Procédé et ensemble destinés à l'analyse d'haleine, l'analyse étant effectuée non seulement sur un gaz expiré mais aussi sur un condensat d'haleine

Country Status (1)

Country Link
WO (1) WO2017054857A1 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130253360A1 (en) * 2010-12-01 2013-09-26 Zhejiang University Integrated analysis device for simultaneously detecting ebcs and vocs in human exhaled breath

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130253360A1 (en) * 2010-12-01 2013-09-26 Zhejiang University Integrated analysis device for simultaneously detecting ebcs and vocs in human exhaled breath

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SANDRA SCHACK: "Untersuchungen zur Anwendbarkeit der Atemkondensatgewinnung beim Pferd und ihre potentiellen Einsatzmöglichkeiten in der Lungendiagnostik", 12 April 2002 (2002-04-12), XP055251963, Retrieved from the Internet <URL:http://geb.uni-giessen.de/geb/volltexte/2002/768/pdf/d020068.pdf> [retrieved on 20160222] *

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