WO2017036605A1 - Adaptateur doté d'un réservoir pour contenant - Google Patents

Adaptateur doté d'un réservoir pour contenant Download PDF

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Publication number
WO2017036605A1
WO2017036605A1 PCT/EP2016/025093 EP2016025093W WO2017036605A1 WO 2017036605 A1 WO2017036605 A1 WO 2017036605A1 EP 2016025093 W EP2016025093 W EP 2016025093W WO 2017036605 A1 WO2017036605 A1 WO 2017036605A1
Authority
WO
WIPO (PCT)
Prior art keywords
reservoir
container
opening
adapter
opening element
Prior art date
Application number
PCT/EP2016/025093
Other languages
German (de)
English (en)
Inventor
Burkhard Metzger
Carolin HOCH
Bruno Guillon
Vincent Sebille
Bruno Guilbert
Florence Bidamant
Original Assignee
Boehringer Ingelheim International Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International Gmbh filed Critical Boehringer Ingelheim International Gmbh
Publication of WO2017036605A1 publication Critical patent/WO2017036605A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1475—Inlet or outlet ports
    • A61J1/1487—Inlet or outlet ports with friction fit, e.g. connecting tubes directly to a protruding port
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/24—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
    • B65D51/28—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials
    • B65D51/2807—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container
    • B65D51/2814—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by piercing, cutting or tearing an element enclosing it
    • B65D51/2821—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by piercing, cutting or tearing an element enclosing it said element being a blister, a capsule or like sealed container
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed

Definitions

  • the present invention relates to an adapter, in particular for connection to a container, according to the preamble of claim 1, a container according to the preamble of claim 14 and a use of an adapter according to the preamble of claim 15.
  • the present invention is concerned with an adapter, in particular for connection to a container opening.
  • the adapter contains a substance which is releasable on the container for the preparation of a mixture or a mixture.
  • DE-PS 460 043 discloses a mixing bottle with an adapter for receiving a solid or liquid mixed component.
  • the mixing component in the adapter in a reservoir is thereby released via an opening element that can be actuated from the outside, so that it falls into the mixing chamber together with the reservoir.
  • the present invention has for its object to provide an adapter, a container and a use of an adapter for a container, wherein a safe and / or comfortable handling and / or repeated removal and the production of an exact or reliable concentration, especially in highly potent liquids or . Medicines are facilitated or facilitated. Further, because of their limited stability, many drugs require preparing a solution or mixture just prior to use.
  • the adapter or the opening element has a connection channel for a removal device.
  • a fluid mixed fluid
  • the adapter is adapted to a connection between the interior of a container and an outside of the container environment or removal device or removal device is formed by the opening element and / or the reservoir therethrough. This enables uncomplicated and application-safe handling.
  • the reservoir is formed by a blister.
  • the substance first enters the container before it can be removed as part of a mixture.
  • the substance taken up by the reservoir can be protected particularly easily and effectively against influences which can lead to a reduction of its durability.
  • the use of a blister allows protection against penetration or damage by moisture and / or oxygen.
  • leakage of the substance in the unopened state can be effectively prevented. This is particularly advantageous in a preferred use of the reservoir for the storage of medical drugs, since an inadvertent contact hereby could have undesirable, if not fatal, effects.
  • the adapter therefore preferably has an opening element with a connection channel.
  • the reservoir is opened and the substance is supplied to the container for mixing with a fluid or other substance located therein. After that opens by pressing the connection channel for removal of the container contents.
  • the opening element is designed such that the reservoir is pressurized, pushed in, invaginated and / or everted to open, preferably whereby the reservoir is opened.
  • the reservoir is breakable by the opening element and / or pierceable, whereby a connection for removing the container contents can be produced.
  • the opening element can thus fulfill a dual function, namely open the reservoir and establish a connection with the container interior for removal. This allows a secure, straightforward, low-error application.
  • the opening element is preferably held on the base body in a non-opening initial position of the reservoir.
  • the opening Clamping element for opening the reservoir in the body pressed or inserted.
  • the opening element for opening the reservoir is movable in a direction facing the container or the reservoir.
  • the opening element is integrated and / or guided in the adapter and / or base body. This allows in particular a simple and secure application.
  • the adapter is designed such that the opening element initially causes only opening of the reservoir in the direction away from the reservoir in the direction away from the opening element direction and only then the access to the container, in particular via the connection channel releases. This ensures that first the mixed fluid must be formed before a withdrawal can take place. Thus, contact with or removal of the pure substance is prevented.
  • the reservoir is preferably integrated in or arranged in the adapter and / or base body. This enables a one-piece, compact solution.
  • connection channel preferably has an at least substantially conical or cylindrical section for the preferably non-positive or tight connection of the removal device.
  • the reservoir is preferably attached to the main body by means of gluing, clamping and / or sealing and / or container side, end, frontally or on a side facing away from the connecting channel of the opening element.
  • the reservoir preferably closes at least substantially tightly with the main body of the adapter and / or closes off the main body.
  • the opening element is preferably movable relative to the reservoir for opening and making the connection for removal.
  • the reservoir is pad-shaped, in particular with a circumferential flange-like edge with which the reservoir is attached to the main body. This allows a secure hold with good accessibility of the cavity and the walls of the cavity for opening through the opening element. It is further preferred that the reservoir has one or more predetermined breaking points for defined opening, preferably on its cover element. This can facilitate the piercing of the reservoir. It is preferred that removal of the mixing fluid takes place through the reservoir.
  • the reservoir as a whole, ie the front or the cover element and the back or the bottom element destroyed for the preparation of the connection for removal.
  • a passage for the mixing fluid through the reservoir or surrounded by the edge of the reservoir is formed.
  • Another, independently realizable aspect of the present invention relates to a container with a proposed adapter, wherein the container contains a fluid and the substance of the reservoir after opening the reservoir with the fluid is miscible.
  • a further, independently realizable aspect of the present invention relates to the use of a proposed adapter for connection to a container, wherein the adapter has an integrated reservoir and a movable opening element for releasing a substance into the container, and wherein by means of a removal device, the opening element is moved or pressed and thereby the reservoir is opened, so that the substance is released into the container and, preferably, subsequently the reservoir is pierced, whereby a connection for the removal of the container contents is made.
  • the reservoir is therefore preferably opened on both sides or on opposite sides for removal.
  • a blister can be understood to mean, in a manner analogous to the packaging industry, a depression in a plastic or aluminum foil (ceramics), which is preferably sealed by a further film.
  • the blister, the blister-like reservoir or a blister-like packaging in the sense of the present invention is in particular a so-called push-through packaging in which material received in the cavity is dispensed by exerting a pressure from one side on an opposite side, preferably by bursting or Tearing the blister on this page.
  • this is a so-called push-through, push or push-through blister.
  • the blister or blister-like reservoir preferably has a lid member having the recess - also called cup or bag - has.
  • the blister or the blister-like reservoir preferably has a bottom element, with which the recess is closed to form a cavity.
  • the cover element and / or the bottom element are preferably in each case foils, in particular aluminum foils or Aluminiumfoilenlaminate or -verbünd substances, or flat material or plate material, in particular thin sheet metal, aluminum sheet o. The like.
  • the depressions are in particular by deep drawing, cold working or hot deformation.
  • the bottom element is preferably arranged in the inserted into the container state with upwardly directed container opening or top mounted adapter below, facing down or into the container or away from the opening element.
  • the bottom element is preferably facing the container interior and / or facing away from the opening element.
  • the cover element is preferably arranged at the top or directed upwards or away from the container or towards the opening element.
  • the cover element is preferably remote from the container interior and / or facing the opening element.
  • the reservoir is preferably arranged and designed such that upon pressure through the opening element onto the reservoir, in particular onto the outer contour of the depression, opening of the reservoir takes place in the direction away from the opening element or towards the interior of the container.
  • the reservoir preferably has differently stable, brittle, brittle or fragile components or sections which directly limit the cavity.
  • the cover element and the base element are mechanically different or fragile mechanically. In this way, it can be achieved that, when the cavity is deformed, when the cavity is pressurized or when an overpressure builds up within the cavity, there is always a specific side or location, in particular a portion of the bottom element that directly delimits the cavity is opened, in particular tears, breaks or bursts.
  • the bottom element is more unstable, fragile, weaker, brittle, brittle and / or thin-walled than the cover element.
  • a preferred or first opening of the cavity in a certain direction preferably in the direction facing away from the opening element, the connection channel or the suction opening or facing the container or container interior, can be advantageously effected or ensured.
  • the bottom element preferably has a so-called blister cover film or is formed thereby. This may, for example, have a (in particular hard) aluminum layer or be at least substantially formed as a result.
  • the layer thickness or material thickness of the bottom element is preferably less than 50 or 30 ⁇ , preferably about 20 ⁇ .
  • the bottom element is preferably so brittle, fragile, fragile and / or brittle that it is possible to push the material out while breaking the bottom element.
  • the cover element preferably has a higher stability or layer thickness than the bottom element.
  • the cover element may comprise a (in particular hard) aluminum layer or at least essentially be formed therefrom.
  • the cover element preferably has a layer thickness or material thickness of more than 80 ⁇ , preferably more than 100 ⁇ and / or less than 300 ⁇ , preferably less than 200 ⁇ , in particular 130 to 170 ⁇ on.
  • the lid member is preferably semi-rigid or has a semi-rigid recess which is sufficiently collapsible to allow for pushing of the fabric through the bottom member by manual indentation or indentation by means of the opening member.
  • the cover element is pierceable, in particular with the opening element.
  • the cover element consists of a brittle material, so that a break can be achieved with low elongation.
  • the use of aluminum is preferred, but the use of plastics or other materials or material mixes is not excluded.
  • the cover element preferably has a layer thickness which is a multiple, preferably at least two, three, four or five times the layer thickness of the bottom element. In this way it can be ensured that pressure on the cover element initially leads to tearing or bursting of the floor element.
  • the bottom element and / or the cover element may be a composite, have one or more coatings or multiple layers.
  • the base element and / or the cover element are produced from coated aluminum foil, for example as is generally known for the production of pharmaceutical blister packs from the prior art.
  • the bottom element and / or the cover element is or are preferably formed in one piece or have one or more holohedral, continuous and / or interruption-free layers over the cavity.
  • the blister or its cavity is preferably produced by sealing, heat sealing, welding or in general by producing a cohesive connection between the bottom element and the cover element.
  • the recesses are particularly preferably first generated, this filled with the substance and then the formation of the blister takes place by enclosing the filled recess.
  • the reservoir preferably has only one cavity. It may alternatively or additionally also be a multi-chamber cavity, in which the cavity is divided, so that areas arise which are separated by a common wall. It is therefore possible for the reservoir to have a cavity with separate regions which, however, adjoin one another directly or are formed by means of one or more common partitions or by dividing the cavity.
  • the reservoir is preferably flat or disk-like with a main extension plane, although several cavities may be arranged side by side or one above the other perpendicular to this main extension plane, but preferably not side by side in the direction of the main extension plane. Furthermore, it is possible that the substance capsules or the like. contains. Such cavities are preferably also understood as blisters with only one cavity.
  • the reservoir is thus preferably not a blister card with a plurality of cavities arranged next to one another which do not adjoin one another directly or have common walls.
  • the reservoir is preferably a disposable container or disposable container or a disposable or disposable packaging.
  • the cavity is preferably sealed, airtight, gas-tight, hermetic and / or uninterrupted, or irreversible or evidently only with destruction or structural impairment to the surroundings of the blister.
  • the reservoir is preferably pad-like or forms a ped.
  • a pedestal can be an at least substantially disc-like container which optionally has a bottom surface forming a flange-like or laterally protruding edge.
  • the reservoir or the blister preferably has a peripheral edge, whereby a, in particular financial intuitions, Päd can be formed.
  • the pedestrian is preferably a portion package, preferably with exactly one portion.
  • the pedestal is preferably formed of two layers of flat material - in the present case preferably the bottom element and the cover element -, wherein these layers are peripherally connected to one another such that the cavity forms between the layers and the edge.
  • the blister or ubend or blisterarige and / or pad-like reservoir preferably forms a shell in which the fabric is enclosed.
  • the reservoir is preferably a blister with only one cavity, which is surrounded by a flange-like edge, so that a pad-like shape is formed.
  • the recess or outward bulge is preferably provided, whereas the bottom element is at least substantially planar or planar.
  • the bottom element also has a depression.
  • the cover element has a smaller depression than the base element or no depression, which can simplify the opening of the reservoir.
  • the reservoir is formed in particular by a so-called asymmetric ubend, in which the cavity predominantly, at least substantially or completely on one side of a plane defined or imagined by the edge, preferably on the side of the cover element or of the opening element.
  • the edge is preferably formed at least partially or substantially by the bottom element connected to the cover element in this area.
  • the blister is preferably closed in the region of the edge or by the edge.
  • the bottom element is connected to the cover element in the region of the edge, so that the cavity is formed.
  • the edge is preferably the section which adjoins the cavity and / or which is formed by the bottom element and the cover element or their composite.
  • the edge is preferably flange-like or laterally projecting.
  • the edge surrounds the cavity preferably ring-like and / or interruption-free.
  • the edge is preferably flat, ring-disk-like and / or symmetrical to a central axis extending transversely to a center or center of gravity of the cavity.
  • the edge is preferably formed in a plane, flat or even.
  • the edge preferably has a material thickness which corresponds at least essentially to the sum of the material thicknesses of the bottom element and the cover element.
  • An edge-side boundary line is preferably formed at least substantially coaxially to a boundary line of the cavity.
  • the edge preferably has an at least substantially constant radial extent.
  • the edge in the radial direction preferably has an extension of more than 0.5 mm, preferably more than 1 mm or 2 mm, and / or less than 6 mm, preferably less than 5 mm or 2 mm, particularly preferably about 3 mm. This allows a secure attachment of the blister by means of the edge or sealing of the adapter.
  • the adapter for connection to a container in addition to a preferably integrated reservoir for a substance to be released on a movable opening element for opening the reservoir, wherein the opening element is held on the base body of the adapter in a non-opening initial position of the reservoir.
  • This preferably allows only when using a sufficiently high and controlled external force, preferably irreversible opening of the reservoir and thus prevents inadvertent opening of the reservoir, for example.
  • the holder of the opening element is very easily realized by a clamping seat or a detent.
  • the receptacle for the removal device on the opening element is designed such that it closes in particular non-positively tight with the removal device.
  • the reservoir is in particular automatically opened.
  • the adapter allows multiple or stepwise removal of the mixing fluid from the container. This allows a repeated use of the adapter or container, wherein, if necessary, different removal devices or for each removal a new removal device can be used.
  • the walls of the reservoir preferably remain on the adapter.
  • the opening element opens in particular at an outer, i. From the side of the container turned off, the reservoir with the substance inside it.
  • the opening element is for this purpose pressed by means of the removal device.
  • the opening element preferably serves as a movable coupling element between the container and the removal device, in particular a pipette, dosing pipette, pipette for oral use, syringe or the like.
  • the fluid mixed after opening of the reservoir or the liquid can therefore in particular directly via the Adapter and / or removed or sucked by means of the removal device.
  • the opening element or a piercing element of the opening element projects beyond an intake opening of the connection channel or lies at least substantially at the same height. This facilitates opening and allows in particular after the complete opening of the reservoir a removal from the container via the connection channel.
  • the container is preferably initially closed by the reservoir, in particular the cover element. Only after the cover element or the reservoir is completely broken, whereby the opening is made via the connection channel.
  • other constructive solutions are possible.
  • the opening element has on the container side or on the reservoir side one or more in particular pointed or edged piercing or piercing elements for opening the reservoir.
  • these piercing elements are adapted to the position of one or more predetermined breaking points of the reservoir.
  • the opening element can be designed to be blunt on the container side or reservoir side so that, when the opening element begins to move, the reservoir is preferably initially pressed, inverted and / or everted on the side facing the container or opening element, for example by bursting and / or or tearing open, and subsequently with the movement of the opening element progresses, the side facing away from the container or opening is opened, in particular by tearing, puncturing, puncturing or puncturing, whereby the adapter and the container are finally opened to the outside for removal.
  • the opening element on the reservoir side one or more piercing elements, which preferably have wing, punch or web-like sections or projections or are formed thereby.
  • the piercing elements are preferably flattened endsteitig or frontally, so that a touchdown on the reservoir to a depression of the reservoir or its cover element leads, initially without in this case the opening element facing the side of the reservoir pierced or pierced.
  • the reservoir is deformed and ruptures or bursts on the side facing away from the opening element or in the region of the bottom element in order to release the substance into the container and to form a mixture with the container contents. This is comparable to pushing out a tablet from a drug blister, but causing the necessary pressure through the orifice member.
  • the suction opening of the opening element preferably forms a fluid passage through the opening element - from an environment of the adapter up to the reservoir - or part of it.
  • the suction opening may be provided in addition to the piercing elements.
  • the intake opening in particular in the middle, is located between the piercing elements.
  • the piercing elements may also be formed together with the suction opening or the suction opening by one or more of the piercing elements.
  • ends or end faces of the piercing elements are located axially at the same or similar height or in or oriented on a common surface or plane or define a common surface or plane.
  • the force acting on the reservoir is initially distributed over a sufficiently large area, so that breakage of the cover element is avoided. This bursts the soil element and releases the substance.
  • the cover element is then perforated by means of the piercing elements, so that a fluidic connection between the interior of the container and the environment can be produced by means of the adapter.
  • the lid member preferably has a convex or outwardly curved outer surface.
  • the lid member is more curved than the bottom element.
  • the bottom element may be at least substantially planar or even. This supports the elongation and breakage of the floor element by pressing in the cover element.
  • one or more of the piercing elements have a more acute corner or edge radially outward than radially inward.
  • the radially inner edge is preferably obtuse. In this way, initially the radially inner, blunt edge acts on the reservoir in order to allow an opening of the cavity towards the interior of the container without piercing the lid element.
  • the cover element By further movement of the opening element in the direction of the container, the point is reached at which the cover element is everted, the surface of the reservoir, which was previously curved convexly or outwards or in the direction of the opening element, by deformation into a concave or inward vaulted surface becomes.
  • the cover element is then arched at least partially in the direction away from the opening element.
  • the radially outer edge of the ends or end faces of the piercing elements is acute-angled or rectangular.
  • the lid element can come into contact with the radially outer, more pointed edges of the piercing elements and be subjected to shearing. This facilitates puncturing or breaking through.
  • the piercing elements sever the cover element of the reservoir, thereby enabling the fluidic connection between the interior of the container and the environment.
  • the suction opening or the section forming this pierces the cover element, whereby a fluidic connection between the interior of the container and the environment can be produced by means of the adapter.
  • the suction opening may be formed or surrounded by a pointed or conically tapered end.
  • the side of the main body facing away from the container can optionally be provided with a diaphragm or engagement opening, which preferably allows the opening element to be moved only by engagement with a suitable removal device and / or with an article formed at least substantially complementary.
  • the reservoir preferably comprises a mechanically easy-to-open wall. This can be realized in particular by a film, preferably made of plastic and / or metal. This facilitates opening. The opening through the opening element can in particular be facilitated by the fact that the reservoir has one or more predefined predetermined breaking points.
  • the reservoir is everted or loaded by the opening element in such a way that the reservoir in particular first tears on the container side. Subsequently, this also takes place on the side facing away from the container so that an opening to the interior of the container is created via the connection channel and removal of the container contents, in particular of a mixture in the form of a fluid, by means of the removal device can be done with preferably placed upside down container.
  • the reservoir is preferably attached to the base body, for example by means of gluing, clamping and / or sealing.
  • the reservoir closes at least substantially tightly with the base body of the adapter and closes the container in particular with likewise tight attachment of the base body to the container.
  • the edge of the reservoir is enclosed by the adapter or base body.
  • the edge or a cut edge of the reservoir in particular before contact with the contents or mixed fluid of the container, is protected or vice versa.
  • the opening element has a valve.
  • This increases the security against an uncontrolled escape of the fluid from the interior of the container, in particular in the case of a reservoir which optionally seals off to the outside but which has already been opened.
  • the valve protects against external interference, z. B. inappropriate handling by a user, since the fluid is then sucked or removed only via the removal channel, if preferably the optionally resilient and / or elastically mounted opening element is actuated, for example.
  • a flap-shaped valve is conceivable, which only opens when inserting a suitably shaped tip, which may be located in particular on the removal device.
  • connection channel it is preferably provided that air can be drawn into the container via a ventilation channel only during removal with a removal device provided for this purpose. This ventilation facilitates the removal of the final mixture or fluid from the container.
  • the adapter to the container can be screwed or clamped with this connectable.
  • This allows a secure attachment of the adapter to the container.
  • a closure or cap is provided, which can be attached with attached adapter for closing and preferably covers the adapter with.
  • the closure may have an integrated repeatable child safety device. This is preferably carried out in the form of a conventional push-turn closure with optional proof of originality.
  • Figure 1 is a perspective vertical section of a proposed container with a proposed adapter according to a preferred embodiment and an associated, not connected removal device.
  • FIG. 2 shows a schematic vertical section of the adapter in a starting position with a still closed reservoir
  • Fig. 3 is a perspective view of the reservoir
  • FIG. 4 shows a schematic vertical section of the adapter with connected removal device and opened reservoir
  • Fig. 5 is an enlarged, schematic perspective view of
  • FIG. 1 shows in a perspective vertical section a preferred embodiment of an adapter 1, here together with or on a container 7 and an associated, not connected removal device 9.
  • the adapter 1 preferably has a main body 2, an opening element 3 and a reservoir 6, which may in particular form an assembly.
  • the base body 2 is shown as the container 7 in Fig. 1 in a perspective vertical section, whereas the movable opening element 3 and the underlying reservoir 6 are shown uncut.
  • the reservoir 6 contains a substance 6A and is manifested by means of the opening element 3 in order to deliver the substance 6A to the associated container 7 or a fluid 7A located therein.
  • Substance 6A is, in particular, a powdered or tabular therapeutic active substance or a medicament. Also possible are a liquid, a gel or a solid.
  • the fluid 7A is in particular a liquid or a powder or other solid forms such as. As pellets or granules.
  • a gas is possible.
  • fluid is thus preferably broadly understood and includes preferably in addition to liquids and other substances with fluid properties or suitability to flow.
  • the fluid 7A may also be a flowable or mixable solid, such as a flowable powder, granules or the like.
  • the fluid 7A is preferably a liquid, a solvent or the like, ie a substance which is in liquid state at room temperature and atmospheric pressure.
  • the container 7 may also have other substances for mixture formation, even if in the following the invention is always explained in connection with the fluid 7A.
  • the fluid 7A is a solvent, diluent and / or a second active ingredient component.
  • the substance 6A and the fluid 7A or other substance which is provided in the container for mixture formation can mix in the container 7 and in particular a suspension, a mixture, an emulsion, a mixture, a solution or the like. here briefly referred to as mixed fluid - form.
  • the "substance” is preferably a solid, active ingredient, powder, granules, Kompaktat, a tablet, capsule, fluid, a liquid o.
  • the substance is preferably to suitable to form a mixture, in particular a solution, a suspension, emulsion or other mixture, in particular a drug-ready mixture or an application form with the fluid or other substance provided in the container for mixture formation.
  • the mixing fluid forms a preferably ready-to-use drug or a therapeutic agent.
  • Advantage for a separate storage of substance 6A and 7A fluid in the container is a longer shelf life of the individual components, especially for highly potent drugs and / or those that require a liquid dosage form.
  • the opening element 3 is preferably movable or depressible for opening the reservoir 6, in particular from the outside.
  • the adapter 1 or the opening element 3 preferably allows a removal of the mixing fluid, in particular by means of the removal device 9, in particular by providing a corresponding access.
  • a removal device 9 in particular a pipette, dosing pipette, syringe or the like can be used.
  • the mixed fluid formed after opening the reservoir 6 in the container 7 is removed or sucked in by means of the removal device 9 and can subsequently be administered to a patient, for example.
  • FIG. 2 shows a schematic vertical section of the proposed adapter 1 according to FIG. 1 with the opening element 3 located in the starting or basic position and with the reservoir 6 not yet open.
  • the adapter 1 is preferably arranged in or on the opening region 7B of the container 7.
  • the adapter 1 is preferably arranged or connected with the container 7 already closed in or on the opening region 7B. It is also possible, the adapter 1 after removing an optional closure 8 (dashed lines indicated) in the opening portion 7B of the container 7 to use or connect. Additionally or alternatively, the adapter 1 can itself form a closure of the container 7.
  • the adapter 1 is preferably connected or connectable to the container 7 via a clamping seat and / or sealing seat.
  • the adapter 1 or main body 2 has a sealing means, such as at least one, preferably a plurality, sealing lamellae 2A, for preferably non-positively and / or positively fluid-tight connection with the container 7.
  • a sealing means such as at least one, preferably a plurality, sealing lamellae 2A, for preferably non-positively and / or positively fluid-tight connection with the container 7.
  • the sealing fins 2A are preferably formed circumferentially or flange and / or are radially. These are in particular integrally formed on the base body 2 of the adapter 1.
  • the sealing lamellae 2A are made from a plastic material that is different from the main body 2, preferably softer, in particular from an elastomer, such as silicone rubber or a thermoplastic elastomer.
  • the adapter 1 in the use state according to FIG. 1 is held in a clamping manner within the opening region 7B of the container 7 via the sealing lamellae 2A.
  • the adapter 1 can also be connected in some other way to the container 7 or opening region 7B and / or external thread 7C, for example by latching, screwing, etc.
  • the adapter 1 in the container 7 and a preferably neck-like opening portion 7 B of the container 7 partially or completely inserted or inserted or the latter can be received.
  • the adapter 1 may be inextricably linked, for example by gluing or sealing, with the container 7. Alternatively, the adapter 1 can also be detachable from the container 7.
  • the adapter 1 or the main body 2 has a preferably circumferential stop or collar 2B.
  • the collar 2B does not protrude radially beyond the core diameter of the external thread 7C, in particular so that preferably the container 7 can be closed by means of the closure 8 even when the adapter 1 is inserted.
  • Fig. 3 shows a perspective view of the reservoir 6.
  • the reservoir 6 is in particular blister- or ubend- or disc-shaped.
  • this is an aluminum blister, preferably aluminum-aluminum blister.
  • the reservoir 6 preferably forms a cavity with the substance 6A therein. But here are also designs with several preferably separate chambers or cavities, possibly also with different materials 6A possible.
  • the reservoir 6 preferably has a base element 6B and / or a cover element 6C and / or an edge 6D.
  • the reservoir 6 is located on the container side on the main body 2 of the adapter 1, in particular below the opening element 3.
  • the reservoir 6 is preferably fixedly fixed to the base body 2, for example, materially bonded and / or fluid-tight and / or by a weld, gluing, clamping, crimping or sealing.
  • the reservoir 6 closes tightly with the outer contour of the main body 2 of the adapter 1 and in particular thereby closes the main body 2 for a tight closure of the container or of the opening region 7B.
  • the edge 6D or a cut edge of the reservoir 6 is in particular completely encompassed or enclosed by the adapter 1 or base body 2.
  • this is realized by means of a deformation of the container-side edge or end of the base body 2, which closes or embraces the edge 6D of the reservoir 6 tightly.
  • the main body 2 can in particular be without interruption circumferentially attached to the edge 6D sealingly, in particular molded, on or sealed, glued and / or received in a groove.
  • the edge 6D or a cutting edge of the reservoir 6 is protected from contact with the fluid of the container 7. This is particularly advantageous in the case of metal-containing walls or foils of the reservoir 6.
  • foils which are made of several layers in different materials, are protected at their cutting edge from chemical reactions such as oxidation by the edge 6D being encompassed.
  • edge 6D is preferably arranged at the end or end side on the base body or a receptacle for the opening element 3 or forms a closure for this purpose.
  • the container can be closed in a fluid-tight manner by means of the adapter 1, preferably wherein the reservoir 6 forms part of the wall closing the container 7.
  • the interior of the container 7 is thus preferably directly bounded by a container wall, the base body 2 and the reservoir 6, preferably its base element 6B.
  • the reservoir 6 has in particular one or more predetermined breaking points 6E for easy and / or defined opening, preferably in the form of material weakening, punching, embossing, grooves, grooves, notches and / or perforations on a wall, such as the bottom element 6B and /. or the lid member 6C.
  • the reservoir 6 is provided with a predetermined breaking point 6E in the form of a preferably cross-shaped notching and / or punching, preferably in the middle region or extending from the center.
  • four or more notch-like desired use points 6E are provided which extend radially.
  • the predetermined breaking points 6E preferably correspond to the reservoir-side end of the opening element 3, in particular to the piercing elements 3B and / or the suction opening 3D, or are arranged or formed complementary thereto.
  • other solutions are possible.
  • the walls of the reservoir 6 are formed in particular of a film, preferably of or comprising plastic or metal, particularly preferably aluminum, into which the substance 6A to be released is preferably tightly sealed, in particular gas-tight or (water) diffusion-tight ,
  • Gas-tight means in particular that no holes, gaps o. The like. Are present, the gas or water vapor exchange with the environment of the reservoir. 6 enable.
  • the reservoir 6 is not a cylinder-piston arrangement or other systems in which a reservoir 6 is formed by mutually displaceable parts, whereby gas or water vapor can enter or leave.
  • the reservoir 6, the bottom element 6B and / or the cover element 6C is / are preferably formed from a material which inhibits or at least substantially prevents a passage of gas, in particular oxygen, and / or water vapor.
  • a material which inhibits or at least substantially prevents a passage of gas in particular oxygen, and / or water vapor.
  • These may be aluminum, PTP aluminum foil, PVC, PVDC, PVDC coated PVC, PVC-PCTFE, OPA-ALU-PVC, laminates or composites.
  • they may be materials which have a water vapor transmission rate or water vapor permeability of less than 0.5 g / m 2 per day, preferably less than 0.2 g / m 2 , in particular less than 0.1 g / m 2 per day (in particular at a temperature of 40 ° C.
  • the movable opening element 3 is used in particular to open the reservoir 6 preferably by tearing, bursting, puncturing, puncturing and / or eversion.
  • the opening element 3 is designed in such a way that it can preferably be pressed into an actuating direction 5 from the outside.
  • the opening element 3 is irreversible and defines movably within the main body 2 in a preferably container-facing and / or reservoir-facing direction.
  • the opening element 3 is held positively and / or non-positively, in particular by the latching projection 2C, in the starting position or starting position.
  • the opening element 3 is designed such that its initial position can be left only after overcoming a greater mechanical resistance, for example realized via a clamping seat or a detent position.
  • the opening element 3 and / or the base body 2 has a latching projection 2C and / or a latching recess 3G.
  • the position of use of the adapter 1 is preferably a depression.
  • the opening element 3 is thereby locked or locked in the end position or secured against removal, preferably latching.
  • the opening element 3 overcomes the or a further latching projection 2C with its latching recess 3G.
  • other corresponding or complementarily formed locking means of the opening element 3 and of the basic body 2 can also form a latching and / or snap connection. As a result, the opening element 3 is held in the end position or stop position.
  • the latching projection 2C is provided in particular at or at the level of a fastening portion, in particular sealing region, of the reservoir 6 on the base body 2 or arranged such that the opening element 3 is locked in its end position or secured against removal.
  • the latching projection 2C or a shoulder of the basic body 2 can be designed to allow a further movement or depression of the opening element 3 from the end position beyond the reservoir 6 into the container 7 and / or to block a movement of the opening element 3 in the direction away from the reservoir 6 from the end position out.
  • the sequence of the opening process in which the reservoir is first opened on a side facing the container and only afterwards on a side facing away from the container, is preferably achieved by different thicknesses / breaking up behavior of the cover element 6C and bottom element 6B, in particular also independently of an intermediate position of the Opening element 3.
  • the opening element 3 has an intermediate position in which the reservoir 6 is opened on the container side, but not yet pierced. In this intermediate position, the reservoir 6 is preferably open towards the container interior, but not yet in the direction of the opening element 3 or its suction opening 3D.
  • the opening element 3 has a pressure point in the intermediate position or is otherwise configured to brake the movement of the opening element 3 in the direction of the reservoir 6, to temporarily inhibit it or to otherwise signal the reaching of the intermediate position.
  • the pressure point can be caused in particular by a latching means or by the fact that the reservoir 6 generates a higher or opposing force when the cover element 3C is pierced than during the preceding deformation of the cover element 3C and opening of the reservoir 6.
  • the intermediate position is preferably characterized by a (latching) position of the opening element 3, at which the opening element 3 is braked or inhibited in its movement in the direction of the reservoir 6.
  • the opening element 3 and the base body 2 preferably have latching means in order to temporarily hold, brake or reversibly restrain the opening element 3 in the intermediate position.
  • the adapter 1 is designed such that a movement of the opening element 3 beyond the intermediate position requires a release, for example, a rotation of the opening member 3 relative to the base body 2 along a common or along the direction of movement of the opening member 3 formed central axis.
  • a Position radially extending guide for the opening element 3 may be provided as a backdrop or the like.
  • the intermediate position can also without the pressure point or without the inhibition, blockage, securing or the like. will be realized.
  • the opening element 3 can first be moved from its initial position into the intermediate position, in particular pushed or pushed. As a result, the reservoir 6 opens and its contents, the substance 6A, is released (into the interior of the container 7). Here, the mixing fluid 7A can be formed.
  • the container 7 is preferably still closed or no connection of the container interior made with the environment of the container.
  • the opening element 3 is preferably moved further in the direction of the reservoir 6 until it reaches an end position, whereby the reservoir 6 is broken by means of the opening element 3.
  • the connection of the container interior is made with the environment, preferably whereby the mixing fluid 7A can be removed via the connection channel 3C from the container interior.
  • the base body 2 has a stop, in particular a collar-like constriction or shoulder, which limits the movement of the opening element 3 and thereby defines the end position.
  • the stop can prevent slippage of the opening element 3 into the container 7.
  • the reservoir 6 is preferably attached with its edge 6D to the stop, the back of the stop or in this area.
  • the opening element 3 is rotationally secured such that it can not be rotated in its axis of symmetry perpendicular to the plane of the container opening 7D.
  • this is realized by means of a guide on the opening element 3 itself and / or on the base body 2.
  • the opening element 3 is preferably conical or cylindrical on the side facing away from the container. In the illustrated example, it has a cylinder portion 3A on the container side facing away from.
  • the base body 2 is preferably designed to guide the opening element 3.
  • the base body 2 forms a linear guide for the opening element 3.
  • the base body 2 is at least for this purpose partially formed complementary to the opening element 3.
  • the base body 2 has a hollow cylindrical section or is formed as a hollow cylinder, preferably such that the opening element 3 can be received in the base body 2, guided in the base body 2 and / or displaceable in the base body 2.
  • the main body 2 with the opening element 3 forms a cylinder-piston arrangement or cylinder-piston-like arrangement, preferably wherein the opening element is movable like a piston in the base body 2, which may be formed like a cylinder.
  • the opening element 3 is guided with other or other outer contours in the base body 2, in particular axially, along a central axis, (common) axis of symmetry o.
  • the opening element 3 on the container side Piercing elements 3B are in particular edged and / or tapered.
  • the piercing elements 3B consist of blunt or planar elements, in particular if the reservoir 6 can simply be completely opened.
  • the opening element 3 preferably has a connection channel 3C with a container-side suction opening 3D and a removal-side outlet opening 3E.
  • a receiving region 3F of the connection channel 3C adjoins the outlet opening 3E.
  • the receiving area 3F is at least substantially cylindrical.
  • the receiving area 3F or the outlet opening 3E has a larger diameter than the connecting channel 3C or the intake opening 3D adjoining the container side.
  • a valve or safety closure, septum or the like may be associated with the withdrawal channel 3C to prevent undesirable leakage of fluid mixture 7A.
  • valves on and / or in the opening element 3 which is preferably mounted resiliently and / or elastically and prevents inadvertent leakage of the fluid mixture 7A, in particular after the opening of the reservoir 6.
  • a valve optionally opens only when reaching or exceeding a certain minimum pressure.
  • a possible constructive solution for a valve is, for example, a spring-mounted and / or diaphragm-like valve, which preferably only when inserting the removal device 9 or a suitable, in particular complementarily shaped object in the opening element 3, in the connection channel 3C, the receiving area 3F and / or in the container side facing away from the ⁇ Stammsele- element 3 opens.
  • the container side facing away from the base body 2 may optionally be provided with a diaphragm, which preferably allows a movement of the opening element 3 only with an associated removal device 9 and / or with an at least substantially complementary shaped object.
  • Fig. 4 shows a schematic vertical section of the proposed adapter 1 according to Fig. 1 with the e.g. By means of removal device 9 actuated opening element 3 and with opened or everted reservoir 6.
  • the removal device 9 shown by way of example is non-positively and / or positively held in the opening element 3, which was moved by means of the removal device 9 from the starting position to an outermost position or opening position in container facing direction.
  • this position is analogous to the starting position of the opening element 3 also fixed in particular latching by means of positive or complementary trained elements, such as a latching projection 2C and / or a detent recess 3G.
  • the piercing element 3B presses onto the reservoir 6.
  • the foil of the reservoir 6 preferably bursts, thus releasing the substance 6A in the reservoir 6 for the fluid 7A in the container.
  • the predetermined breaking points 6E are in particular designed and arranged such that it is adapted to facilitate the opening to the position of the piercing element 3B.
  • the piercing element 3B presses on the predetermined breaking point of the wall of the reservoir 6.
  • the reservoir 6 first opens at least essentially on the base element 6B and only then the cover element 6C. As a result, preferably dissolves the entire contents of the reservoir 6 and is released into the container 7.
  • the bottom element 6B has an easier-to-open wall than the cover element 6C.
  • the walls preferably remain at least substantially at the adapter 1 or the base body 2.
  • the opening element 3 is preferably actuated by means of the removal device 9 in that the end region 9E is introduced into the opening element 3 and the removal element 9 then moves the opening element 3 toward the side facing the container.
  • the opening element 3 or the piercing element 3B is lowered at least to the level of the bottom element 6B of the reservoir 6.
  • an opening of the reservoir 6 is to be ensured safe.
  • a support of the mixing process of the fluid mixture 7A eg. By shaking or panning.
  • the removal device 9 preferably remains tightly closed in the removal channel 3C.
  • the removal device 9 preferably has a housing 9C.
  • This has in particular a connection section or end region 9E, which can be connected to the adapter 1 or removal channel 3C or receiving region 3F in a fluid-tight manner, in particular into the receiving region 3F.
  • the receiving region 3F and the end region 9E are formed at least substantially complementary to one another.
  • the receiving area 3F and the end area 9E allow a standardized connection, in particular a so-called "Luer connection", a connection of this type with a different, preferably larger cone or diameter than that of the "Luer cone” or a similar connection.
  • connection channel 3C of the adapter 1 or of the opening element 3 and of the end region 9E of the removal device 9 a frictionally sealing connection can be produced.
  • the connection channel 3C preferably has an inner cone or the connection channel 3C is formed or bounded with or by an inner cone.
  • the receiving area 3F and / or the end area 9E are preferably conical with the same or similar cone. This allows or facilitates a tight connection with reduced force in the axial direction or connecting direction.
  • the cone preferably has a minimum diameter of more than 4 mm, in particular 4 to 6 mm or about 5 mm. As a result, a tight connection of syringes is avoided and / or a selectivity for the removal device 9 is achieved.
  • the removal device 9 or the housing 9C preferably has an inclined or conically formed shoulder region 9D which carries or forms the end region 9E, in particular so that a ventilation channel 4 is not closed when removal device 9 is connected to the adapter 1.
  • the removal device 9 or the housing 9C preferably has a displaceable piston 9A for receiving or sucking in the container contents or the fluid mixture 7A from the container 7.
  • the piston 9A is provided with an associated operating handle 9B and / or actuated, in this case in the housing 9C in particular axially displaceable.
  • the piston 9A is provided with an associated operating handle 9B and / or actuated, in this case in the housing 9C in particular axially displaceable.
  • other constructive solutions are possible.
  • the container 7 For the removal of the mixing fluid 7A from the container 7, the container 7 is preferably held upside down, ie with the opening portion 7B or the opening 7D with the enclosed or inserted adapter 1 facing down, so that in the container 7 contained fluid mixture 7A on Adapter 1 is pending.
  • the "overhead turning" of the container 7 is preferably carried out after insertion of the removal device 9 in order to avoid an undesired escape of the mixing fluid 7A through the removal channel 3C due to the overhead rotation before the connection of the removal device 9.
  • the adapter 1 allows a multiple or stepwise removal of the mixing fluid 7A from the container 7 in particular in desired doses by means of the removal device.
  • the container 7 or adapter 1 is preferably closed with the closure 8 between the withdrawals so that it closes the container 7 tight and thus protects the mixing fluid 7A in particular from air exchange.
  • the removal device 9 is a suitable apparatus for metered removal of liquids.
  • the removal device 9F is particularly preferably a syringe, a micropipette or a hand dispenser, that is, in particular piston reciprocating devices, which allow a preferably exact metering of the fluid mixture 7A from the container 7 by suction.
  • a manual and an electrical control of the removal direction 9F is possible.
  • the base body 2 or the opening element 3 preferably has a ventilation channel 4.
  • the intake opening 3D is radially offset or radially spaced from the air outlet of a preferably tubular ventilation duct 4 (see also FIG. 5). This prevents in particular that air can be sucked in directly during the removal process and / or a negative pressure builds up in the container.
  • FIG. 5 shows an enlarged, schematic perspective view of the proposed adapter 1 for connection to a container 7.
  • the orientation data "radial” or “axial” refer in particular to FIG. 2 and FIG. 4 to the direction along the main extension of the removal channel 3C and / or at least substantially along the central axis of the adapter 1 or the basic body 2 or the opening region 7B or parallel thereto. If the optional ventilation channel 4 is not provided with a non-return valve or the like, it is theoretically possible, particularly if improperly handled, to discharge the mixed fluid 7A through the ventilation channel 4 in an undesired manner out of the container 7.
  • the cross-section of the ventilation duct 4 is preferably chosen to be so large that no undesired capillary forces occur which could cause the mixing fluid 7A to suck into the ventilation duct 4.
  • the cross-section of the ventilation duct 4 - in particular regionally or on the tank side - may also be chosen to be so small that occurring capillary forces reliably hold mixing fluid 7A entering the ventilation duct 4 in the ventilation duct 4.
  • the ventilation channel 4 preferably has a substantially smaller cross-section than the removal channel 3C.
  • the smallest cross section of the removal channel 30 is at least 50%, preferably 100% or more, larger than the smallest cross section of the ventilation channel 4.
  • the term "cross section" here refers selectively to the cross sectional area or the diameter. This assists that the fluid mixture 7A does not undesirably exit through the ventilation duct 4.
  • the adapter 1 has an at least substantially cylindrical or conical basic body 2.
  • the base body 2 at least partially on an at least substantially hollow cylindrical and / or conical body.
  • the adapter 1 or main body 2 or the opening element 3 are preferably made of different plastics, in particular with or made of polypropylene and polyethylene.
  • the opening element 3 is made of polypropylene and the base body 2 is formed with or made of polyethylene. Both elements can also be made of the same plastic.
  • the base body 2 and / or the opening element 3 are integrally formed.
  • the container 7 may in particular be a bottle or the like.
  • the container 7 is preferably dimensionally stable.
  • the container 7 may optionally be soft or deformable, rigid or rigid, that is to say in particular non-deformable, or semi-rigid.
  • the container 7 preferably has an opening region 7B, in particular at least substantially hollow cylindrical or conical, for receiving the adapter 1 or for removing the fluid mixture 7A.
  • the container 7 or the opening portion 7B on the outside a holding means or external thread 7C for receiving or securing a closure 8 for the container 7.
  • the closure 8 is in particular a rotary closure and / or has a child safety lock.
  • other solutions are also conceivable here.
  • the container 7 and the adapter 1 with an optional closure 8 and / or an optional removal device preferably form a kit or an independently marketable sales unit.
  • the container 7, the adapter 1 with an optional closure 8 and the removal device 9 form a proposed removal system for the particularly metered preparation of the fluid mixture 7A, in particular a liquid.
  • the components of the proposed kit or system are placed on the market in a common package or the like. However, it is also possible that said components form a loose composite for joint use.
  • the proposed adapter 1 is also separately marketable. In particular, it can also be used as needed only locally in the container 7 or connected to this.
  • the adapter 1 may form a closure 8 of the container 7 and, for example, to open the ventilation channel 4 and / or the removal channel 3C - optionally by actuating the opening element 3, in particular only by preferably completely opening the reservoir 6 become.
  • the adapter 1 may additionally be provided with a corresponding closure, not shown, for example a sealing film or the like.

Abstract

L'invention concerne un adaptateur, un contenant équipé de ce dernier et une utilisation de l'adaptateur, l'adaptateur comprenant un corps de base, un réservoir destiné à une substance à administrer et un élément d'ouverture mobile permettant d'ouvrir le réservoir, l'élément d'ouverture présentant un canal de raccordement destiné à un dispositif de prélèvement; et/ou l'adaptateur étant conçu de manière à ce qu'une liaison soit formée entre l'intérieur du contenant et un environnement ou un dispositif de prélèvement hors du contenant, passant par l'élément d'ouverture et/ou le réservoir; et/ou le réservoir étant constitué d'un blister.
PCT/EP2016/025093 2015-09-03 2016-08-31 Adaptateur doté d'un réservoir pour contenant WO2017036605A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15002593.0 2015-09-03
EP15002593 2015-09-03

Publications (1)

Publication Number Publication Date
WO2017036605A1 true WO2017036605A1 (fr) 2017-03-09

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Application Number Title Priority Date Filing Date
PCT/EP2016/025093 WO2017036605A1 (fr) 2015-09-03 2016-08-31 Adaptateur doté d'un réservoir pour contenant

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WO (1) WO2017036605A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102022116057A1 (de) 2022-06-28 2023-12-28 Sarstedt Ag & Co. Kg Verfahren zur Herstellung eines Druckausgleichs sowie zugehöriges Set

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000019961A1 (fr) * 1998-10-02 2000-04-13 Giuseppe Santoro Receptacle pour medicaments injectables constitues de deux phases
US20020040856A1 (en) * 1997-10-14 2002-04-11 Bo Mollstam Two-compartment container

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020040856A1 (en) * 1997-10-14 2002-04-11 Bo Mollstam Two-compartment container
WO2000019961A1 (fr) * 1998-10-02 2000-04-13 Giuseppe Santoro Receptacle pour medicaments injectables constitues de deux phases

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102022116057A1 (de) 2022-06-28 2023-12-28 Sarstedt Ag & Co. Kg Verfahren zur Herstellung eines Druckausgleichs sowie zugehöriges Set

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