WO2017020795A1 - 一种角膜保存和复水装置 - Google Patents

一种角膜保存和复水装置 Download PDF

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Publication number
WO2017020795A1
WO2017020795A1 PCT/CN2016/092432 CN2016092432W WO2017020795A1 WO 2017020795 A1 WO2017020795 A1 WO 2017020795A1 CN 2016092432 W CN2016092432 W CN 2016092432W WO 2017020795 A1 WO2017020795 A1 WO 2017020795A1
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WO
WIPO (PCT)
Prior art keywords
cornea
corneal
box body
lid
rehydration
Prior art date
Application number
PCT/CN2016/092432
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English (en)
French (fr)
Inventor
王维博
张斌
Original Assignee
深圳艾尼尔角膜工程有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201510466857.7A external-priority patent/CN105076111B/zh
Priority claimed from CN201520572717.3U external-priority patent/CN204860784U/zh
Application filed by 深圳艾尼尔角膜工程有限公司 filed Critical 深圳艾尼尔角膜工程有限公司
Priority to US15/745,123 priority Critical patent/US10952429B2/en
Publication of WO2017020795A1 publication Critical patent/WO2017020795A1/zh

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0263—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
    • A01N1/0273—Transport containers
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0263—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0095—Packages or dispensers for prostheses or other implants

Definitions

  • the invention relates to the technical field of corneal preservation, in particular to a corneal preservation and rehydration device.
  • the cornea is a transparent film at the front of the eye.
  • the cornea used in corneal transplantation can donate the cornea to the artificial cornea or the human body.
  • the prior art packaging box is a vial or a common box structure, and the cornea is directly placed in the box for storage.
  • the cornea is likely to cause the cornea to slip, subvert, wrinkle or deform, or even be damaged during the transportation and transportation to the clinical use, in a package preserved using a desiccant.
  • the sliding of the cornea will cause the cornea to be contaminated by contact with the desiccant, and it is difficult to maintain the original shape, and it is also likely to cause changes in the positive and negative directions of the artificial biological cornea, thereby affecting clinical use.
  • the prior art rehydration process requires the clinician to remove the cornea and complete it in another container, which undoubtedly increases the risk of contamination and damage to the cornea.
  • Embodiments of the present invention provide a corneal preservation and rehydration device, which can achieve effective positioning of the cornea, fixed preservation, and maintain the original shape of the cornea, thereby preventing deformation of the cornea during transportation.
  • embodiments of the present invention provide a corneal preservation and rehydration device including a case body and a lid, the case body being detachably coupled to the cover body, and the case body is provided for carrying a cornea
  • the cornea bracket has a convex spherical surface for placing the cornea, and a stopper for preventing the cornea from falling out around the convex spherical surface.
  • a corneal preservation and rehydration device is provided. Since a corneal bracket for carrying a cornea is provided in the cartridge body, the cornea can be placed on the corneal tray, because the corneal bracket is used for placing the cornea surface.
  • the convex spherical surface, and the cornea is a convex spherical type sheet structure, so the cornea can be attached to the convex spherical surface to maintain the structural shape of the cornea, and the cornea cannot be removed from the convex spherical surface to prevent the cornea from falling out.
  • the convex sphere slides down. Before using the cornea, water can be injected into the box to soak the cornea in water to rehydrate it.
  • the cornea can be effectively positioned and fixed by using the above-mentioned corneal preservation and rehydration device to store the cornea, thereby preventing the cornea from being deformed during transportation and transportation, and the cornea can be performed in the device before use. Rehydration reduces the risk of contaminating the cornea with rehydration with other containers.
  • FIG. 1 is an assembled view of a corneal preservation and rehydration device according to an embodiment of the present invention
  • FIG. 2 is a cross-sectional view of the bottom of the capsule of the corneal preservation and rehydration device of the embodiment of the present invention
  • FIG. 3 is a perspective view of a bottom of a box for a corneal preservation and rehydration device according to an embodiment of the present invention
  • FIG. 4 is a perspective view of a box body of a corneal preservation and rehydration device according to an embodiment of the present invention
  • Figure 5 is a cross-sectional view showing a lid of a corneal preservation and rehydration device according to an embodiment of the present invention
  • Figure 6 is a perspective view of a lid of a corneal preservation and rehydration device according to an embodiment of the present invention.
  • Figure 7 is a cross-sectional view showing the casing of the corneal preservation and rehydration device of the embodiment of the present invention.
  • Figure 8 is a perspective view of a corneal preservation and rehydration device in accordance with an embodiment of the present invention.
  • the cornea preservation and rehydration device of the present embodiment includes a case and a lid 1, the case and the cover 1 detachably connected, the capsule body is provided with a cornea bracket 2 for carrying a cornea, the surface of the cornea bracket 2 for placing the cornea is a convex spherical surface 21, and the convex spherical surface 21 is provided around the convex spherical surface 21 for preventing the cornea from falling out Stop 22 .
  • a corneal preservation and rehydration device is provided. Since the cornea bracket 2 for carrying the cornea is provided in the cartridge body, the cornea can be placed on the corneal tray 2, because the corneal bracket 2 is used for placing the cornea.
  • the surface is a convex spherical surface 21, and the cornea is a convex spherical type sheet structure, so that the cornea can be attached to the convex spherical surface 21 to maintain the original structural shape of the cornea, since the convex spherical surface 21 is provided around the convex spherical surface 21 for preventing the cornea from falling out.
  • the dam 22 is so that the cornea cannot slip off the convex spherical surface 21.
  • the cornea Before using the cornea, water can be injected into the box to soak the cornea in water to rehydrate it.
  • the cornea can be effectively positioned and fixed by using the above-mentioned corneal preservation and rehydration device to store the cornea, thereby preventing the cornea from being deformed during transportation and transportation, and the cornea can be performed in the device before use. Rehydration reduces the risk of contaminating the cornea with rehydration with other containers.
  • connection form between the box body and the cover 1 can be designed as a detachable connection to facilitate the placement and removal of the cornea, and in order to realize the case and the cover 1
  • the detachable connection between the case and the cover 1 can be made as shown in FIG. 1.
  • the outer wall of the top of the case 1 is provided with external threads
  • the inner wall of the bottom of the cover 1 is provided with Internal thread that mates with the external thread.
  • the threaded connection between the box body and the lid 1 can make the assembly and disassembly process of the lid 1 simple and stable.
  • the box body can adopt the structure shown in FIG. 1.
  • the box body comprises a box body 3 and a box bottom 4 at the bottom of the box body 3.
  • the cornea bracket 2 is located above the box bottom 4, and the box bottom 4 and the cornea Between the brackets 2, a receiving cavity 5 is provided.
  • the cover 1 is used to cover the casing, and the cornea carrier 2 and the cover 1 have a cornea bearing space, and the receiving cavity 5 communicates with the corneal bearing space, thereby When a substance having a specific action is placed in the accommodating chamber 5, the working space of the substance can be expanded to the corneal bearing space, so that the cornea placed in the corneal bearing space can function.
  • a desiccant having a dry cornea effect in order to dry and preserve the cornea, a desiccant having a dry cornea effect can be placed in the accommodating chamber 5.
  • a desiccant 6 is placed in the accommodating chamber 5, and the desiccant 6 can absorb the moisture at the cornea position. Thereby achieving a dry preservation of the cornea.
  • the accommodating chamber 5 is provided with a limiting structure 7 for fixing the desiccant 6.
  • the limiting structure 7 can adopt the structure as shown in FIG. 2, specifically, The limiting structure 7 is a plurality of buckles, and the lower ends of the plurality of buckles are connected to the bottom of the receiving cavity 5, the gap width between the adjacent two buckles is smaller than the maximum width of the desiccant 6, and each of the buckles comprises a vertical convex Up to 71 and the horizontal protrusions 72, the vertical protrusions 71 can be formed as a rectangular parallelepiped structure as shown in FIG.
  • the horizontal protrusions 72 are disposed on the vertical protrusions 71.
  • the top portion, and facing the central axis direction of the plurality of buckles, the plurality of snap vertical protrusions 71 are used to prevent the desiccant 6 from moving horizontally, and the plurality of buckle horizontal protrusions 72 are used to block the upper and lower sides of the desiccant 6 Tilting, thereby defining the position of the desiccant 6.
  • the connection between the box body 3 and the bottom 4 of the box can be designed as a detachable connection to facilitate the placement and removal of the desiccant.
  • the box bottom 4 adopts a structure as shown in FIG. 3.
  • the box bottom 4 includes a base 41 and a cylindrical protrusion 42 disposed on the upper surface of the base, and is cylindrical.
  • the cavity surrounded by the protrusion 42 is a receiving cavity 5, and the cylindrical protrusion 42
  • the outer wall is provided with an external thread, and as shown in Fig. 7, the inner wall of the bottom of the casing 3 is provided with an internal thread engageable with the external thread.
  • the stopping portion 22 may be a cylindrical cylindrical structure whose lower end is connected to the edge of the convex spherical surface 21, and may also be a plurality of protruding pillar structures disposed around the convex spherical surface 21.
  • the second solution can be used to properly design the gap between two adjacent protrusions.
  • the width of the gap is made smaller than the maximum width of the cornea, which is larger than The width of the special iliac crest of the cornea is taken to effectively stop the cornea from sliding off the convex spherical surface 21, and at the same time, it is convenient to use a special sputum to place or take the cornea.
  • the stopper portion 22 is a plurality of pillar structures provided around the convex spherical surface 21, for example, it can be configured as shown in FIG. 4, that is, the stopper portion 22 includes a plurality of protrusions disposed around the convex spherical surface 21, adjacent to each other.
  • the two columns have a certain gap between them, and the width of the gap is 1 to 3 mm, so as to effectively stop the cornea from sliding and wrinkling deformation from the convex spherical surface 21, and at the same time, it is convenient to use a special file to place or take the cornea.
  • the corneal preservation and rehydration device may be provided with the stopper 22 to prevent the cornea from sliding off the convex spherical surface 21, and the lower surface of the lid 1 may be reasonably set.
  • a distance between the upper surfaces of the stoppers 22 to prevent the cornea from falling out from between the lower surface of the cover 1 and the upper surface of the stopper 22, specifically, the distance between the upper surface of the stopper 22 and the lower surface of the cover 1 It is set to be less than 0.2 mm to prevent the cornea from falling out between the lower surface of the cover 1 and the upper surface of the stopper 22 due to excessive vibration of the upper and lower sides during moving transportation.
  • the height of the above-mentioned convex column can be set to be smaller than the diameter of the cornea, or even lower, in short, through the above-mentioned convex column
  • the height setting and the distance between the stop portion 22 and the lid 1 can effectively prevent the cornea from being subverted, thereby avoiding the influence on clinical use.
  • the position of the stop portion 22 can be designed to be higher, so that the highest point of the stop portion 22 is close to the lower surface of the cover 1, That is, the highest point of the stop portion 22 is higher than the upper end surface of the casing, and vice versa, the outer wall of the cover 1 is designed to be lower, so that the lower surface of the cover 1 is higher than the highest of the stop portion 22. That is, the highest point of the stopper 22 is lower than the upper end surface of the casing.
  • the special cymbal When the highest point of the stopping portion 22 is higher than the upper end surface of the casing, the special cymbal can extend into the convex spherical surface 21 region by the side gap of the stopping portion 22, so as to conveniently place or grasp the cornea with a special sputum, at this time, rehydration
  • the operation may be: pouring water into the box body 3, removing the cornea from the convex spherical surface 21 by using a special sputum, putting it into the water of the box body 3 for rehydration, and taking it out after a period of time, that is, the rehydration operation of the cornea is completed.
  • the liquid level of the preservation liquid in the box body can reach the position where the cornea is completely submerged, thereby effectively performing the cornea.
  • the specific process of the rehydration operation can be simplified as follows: directly injecting water into the box body to soak the cornea in the water, and take it out after a period of time. That is, the rehydration of the cornea is completed, and the operation is simple and convenient.
  • the water used for rehydration is water for clinical use, preferably water for injection.
  • the highest point of the stopping portion 22 is the highest point of the plurality of studs. Specifically, when the heights of the plurality of studs are equal, the highest position of the stopping portion 22 is the top position of any of the studs; When the heights of the studs are inconsistent, the highest point of the stop portion 22 is the top end position of the highest stud among the plurality of studs.
  • the recessed portion 11 may adopt a structure as shown in FIG. 6, that is, the shape of the recessed portion 11 is a regular hexagon.
  • the shape of the recessed portion 11 may also be The position of the recessed portion 11 may be a central position of the cover 1 or a central position of the cover 1, which is not limited herein.
  • the cornea bracket 2 can adopt a structure as shown in FIG. 7.
  • the cornea bracket 2 includes a pallet 23 and a boss 24 provided on the pallet, and the boss 24 is convex toward the direction of the lid 1, and is convex.
  • the upper surface of the table 24 is a convex spherical surface 21 for placing a cornea
  • the supporting plate 23 is for supporting a boss 24 provided thereon.
  • the edge of the supporting plate 23 is connected to the inner wall of the casing 3, and the supporting plate 23 is opened therethrough.
  • the through hole 25 of the upper and lower surfaces of the pallet 23 communicates with the upper and lower cavities separated by the pallet 23, wherein the cavity below the pallet 23 is the accommodating cavity 5, and the cavity above the pallet 23 is
  • the cornea carries space for placement of the cornea.
  • connection between the pallet 23 and the casing 3 can be made detachable, and the pallet 23 and the casing 3 can be made into an integrally formed structure.
  • the tray 23 and the box body 3 are two different parts, which need to be separately produced, and the manufacturing process is complicated. Therefore, in order to avoid the above problem, it is preferable to form the pallet 23 and the casing 3 into an integrally formed structure, for example, a structure as shown in Fig. 7, thereby simplifying the manufacturing process.
  • boss 24 may be of a cylindrical shape or a rectangular parallelepiped shape. Of course, the boss 24 may have other shapes, which is not limited thereto.
  • the pallet 23 since the pallet 23 is used to support the boss 24 provided thereon, the pallet 23 receives the pressure from the boss 24, and in order to prevent the pallet 23 from being deformed by the pressure, it is necessary to rationally design the structure of the pallet 23.
  • the pallet 23 may have a conical plate structure or a flat plate structure. When the pallet 23 is subjected to a constant pressure from the boss, the conical plate structure is less likely to be deformed than the flat plate structure. Therefore, it is preferable to form the pallet 23 into a conical plate structure, for example, as shown in FIG. Conical plate structure.
  • the through holes 25 are uniformly arranged on the conical plate, and each of the through holes 25 may have a shape of a rectangle, a circle or a polygon, or the like. It is not limited here.
  • an insulating structure can be provided in the corneal preservation and rehydration device.
  • the side wall of the casing can be made into a double-layer structure, and the inner side wall of the casing is There is a gap between the outer wall and the outer side wall, and the gap is filled with air. Since the air is a poor conductor of heat, the corneal preservation and heat exchange between the inside and the outside of the rehydration device can be hindered, thereby achieving constant temperature preservation of the cornea.
  • the side wall of the box body has a double-layer structure, and the gap between the two side walls is filled with air.
  • reinforcing ribs may be disposed in the gap of the double layer structure. In order to prevent the casing from being deformed by being squeezed by the outside world.
  • a first sealing ring 8 can be provided at the junction of the box body 3 and the lid 1, and a second sealing ring can be provided at the junction of the box bottom 4 and the box body 3.
  • a groove for placing the first sealing ring 8 may be disposed around the outer wall of the case 3, and the depth of the groove is smaller than the diameter of the first sealing ring 8, and then the first sealing ring 8 is placed in the concave In the groove;
  • a groove for placing the second sealing ring 9 may be disposed around the outer wall of the cylindrical protrusion 42 and the depth of the groove is small At the diameter of the second sealing ring 9, the second sealing ring 9 is then placed in the groove.
  • the portion of the first sealing ring 8 located outside the groove can be pressed by the inner side wall of the lid 1, thereby achieving the sealed connection between the box body 3 and the lid 1;
  • the portion of the second seal ring 9 located outside the recess can be pressed by the inner side wall of the box body 3, thereby achieving a sealed connection between the box bottom 4 and the box body 3.
  • the curvature of the convex spherical surface 21 is close to the curvature of the cornea so that the cornea and the convex spherical surface 21 can be completely fitted, thereby effectively preventing corneal deformation.
  • the first anti-slip protrusion 12 and the second anti-slip protrusion 43 are respectively disposed on the outer wall of the cover 1 and the outer wall of the box bottom 4 to facilitate the realization between the box body 3 and the cover 1 and the box body 3. Disassembly and installation between the bottom 4 and the bottom of the box.

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Abstract

一种角膜保存和复水装置，涉及眼角膜保存技术领域。为解决现有技术角膜包装盒未对角膜进行有效定位的问题。该角膜保存和复水装置包括：盒体和盒盖（1），所述盒体与所述盒盖可拆卸连接，所述盒体内设有用于承载角膜的角膜托架（2），所述角膜托架用于放置角膜的表面为凸球面（21），所述凸球面周围设有用于防止角膜掉出的止挡部（22）。该角膜保存和复水装置可用于角膜包装、保存、运输，以及角膜使用前的复水。

Description

一种角膜保存和复水装置
本申请要求于2015年7月31日提交中国专利局、申请号为201510466857.7、发明名称为“一种角膜保存和复水装置”的中国专利申请的优先权，其全部内容通过引用结合在本申请中。
技术领域
本发明涉及眼角膜保存技术领域，尤其涉及一种角膜保存和复水装置。
背景技术
眼角膜是眼睛前端一层透明薄膜。当角膜损坏或发生病变时，需要通过角膜移植手术进行治疗。而角膜移植手术使用的角膜可以为人工生物眼角膜或人体捐献眼角膜。
人工生物眼角膜或人体捐献眼角膜在进行移植手术前，都需要对其进行包装、保存和运输，避免角膜在储运过程中污染或变质。在角膜保存过程中，通常需要对角膜进行保存或干燥保存，而干燥保存的角膜，在使用之前，需要将角膜放置于水中进行复水。
现有技术的包装盒为西林瓶或普通的盒体结构，直接将角膜放置于盒体内保存。这样，由于在包装盒内没有对角膜进行有效定位，使得角膜在移动运输过程中至临床使用之前，容易导致角膜滑落、颠覆，发生褶皱或变形，甚至损坏，在使用干燥剂保存的包装盒中，角膜移动滑落将会导致角膜与干燥剂接触而受到污染，不易保持原有的形状，也容易导致人工生物角膜的正反方向发生改变，从而影响临床使用。并且，在进行移植手术前，通常需要对角膜进行复水，现有技术的复水过程需要临床医生将角膜取出，在另一容器中完成，这无疑增加了角膜被污染和损坏的风险。
发明内容
本发明的实施例提供一种角膜保存和复水装置，能够实现角膜的有效定位，固定保存，保持角膜原有形状，从而避免角膜在移动运输过程中发生变形。
为达到以上目的，本发明的实施例提供了一种角膜保存和复水装置，包括盒体和盒盖，所述盒体与所述盒盖可拆卸连接，所述盒体内设有用于承载角膜的角膜托架，所述角膜托架用于放置角膜的表面为凸球面，所述凸球面周围设有用于防止角膜掉出的止挡部。
本发明实施例提供的一种角膜保存和复水装置，由于盒体内设有用于承载角膜的角膜托架，因此可将角膜放置于角膜托架上，由于角膜托架用于放置角膜的表面为凸球面，且角膜为凸球型片体结构，因此角膜可以与凸球面相贴合，以保持角膜的结构形状，由于凸球面周围设有用于防止角膜掉出的止挡部，因此角膜不能从凸球面滑落。在使用角膜之前，可向盒体中注入水，使角膜浸泡于水中使其复水。与现有技术相比，采用上述角膜保存和复水装置包装角膜，能够实现角膜的有效定位，固定保存，从而避免角膜在移动运输过程中发生变形，并且，角膜使用前可在本装置内进行复水，降低了使用其他容器复水而使角膜受到污染的风险。
附图说明
为了更清楚地说明本发明实施例或现有技术中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。
图1为本发明实施例角膜保存和复水装置的装配图；
图2为本发明实施例角膜保存和复水装置的盒底的剖视图；
图3为本发明实施例角膜保存和复水装置的盒底的立体图；
图4为本发明实施例角膜保存和复水装置的盒身的立体图；
图5为本发明实施例角膜保存和复水装置的盒盖的剖视图；
图6为本发明实施例角膜保存和复水装置的盒盖的立体图；
图7为本发明实施例角膜保存和复水装置的盒身的剖视图；
图8为本发明实施例角膜保存和复水装置的立体图。
具体实施方式
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
在本发明的描述中，需要理解的是，术语“中心”、“上”、“下”、“前”、“后”、“左”、“右”、“竖直”、“水平”、“顶”、“底”、“内”、“外”等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便于描述本发明和简化描述，而不是指示或暗示所指的装置或部件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本发明的限制。在本发明的描述中，除非另有说明，“多个”的含义是两个或两个以上。
参照图1，图1为本发明实施例角膜保存和复水装置的一个具体实施例，本实施例的角膜保存和复水装置包括盒体和盒盖1，所述盒体与所述盒盖1可拆卸连接，所述盒体内设有用于承载角膜的角膜托架2，所述角膜托架2用于放置角膜的表面为凸球面21，所述凸球面21周围设有用于防止角膜掉出的止挡部22。
本发明实施例提供的一种角膜保存和复水装置，由于盒体内设有用于承载角膜的角膜托架2，因此可将角膜放置于角膜托架2上，由于角膜托架2用于放置角膜的表面为凸球面21，且角膜为凸球型片体结构，因此角膜可以与凸球面21贴合，以保持角膜原有的结构形状，由于凸球面21周围设有用于防止角膜掉出的止挡部22，因此角膜不能从凸球面21滑落。在使用角膜之前，可向盒体中注入水，使角膜浸泡于水中使其复水。与现有技术相比，采用上述角膜保存和复水装置包装角膜，能够实现角膜的有效定位，固定保存，从而避免角膜在移动运输过程中发生变形，并且，角膜使用前可在本装置内进行复水，降低了使用其他容器复水而使角膜受到污染的风险。
在上述实施例中，盒体与盒盖1之间的连接形式可以设计为可拆卸连接，以方便角膜的放置与取出，且为了实现盒体与盒盖1之 间的可拆卸连接，盒体与盒盖1之间的连接部分可以制作为如图1所示的结构，具体地，盒体1顶部外壁设有外螺纹，盒盖1的底部内壁设有可与该外螺纹配合的内螺纹。盒体与盒盖1之间的螺纹连接结构，可使盒盖1的拆装过程简单、平稳。
其中，盒体可以采用如图1所示的结构，参见图1，盒体包括盒身3和位于盒身3底部的盒底4，角膜托架2位于盒底4上方，盒底4与角膜托架2之间设有容纳腔5，盒盖1用于盖住盒体，角膜托架2与盒盖1之间具有角膜承载空间，且容纳腔5与角膜承载空间连通，由此，当容纳腔5中放置具有特定作用的物质时，该物质的作用空间可以扩展至角膜承载空间，从而可以对角膜承载空间内放置的角膜发挥作用。
在上述实施例中，为了对角膜进行干燥保存，容纳腔5中可以放置具有干燥角膜作用的干燥剂，参见图1，容纳腔5内放置有干燥剂6，干燥剂6能够吸收角膜位置的水分，从而实现了角膜的干燥保存。
进一步地，为了固定存放于容纳腔5内的干燥剂6，容纳腔5内设有用于固定干燥剂6的限位结构7，限位结构7可以采用如图2所示的结构，具体地，限位结构7为多个卡扣，多个卡扣下端与容纳腔5的底部连接，相邻两个卡扣之间的间隙宽度小于干燥剂6的最大宽度，每个卡扣包括竖直凸起71以及水平凸起72，竖直凸起71可以制作为如图2所示的长方体结构，还可以制作为圆柱体结构，在此不做限定，水平凸起72设置于竖直凸起71顶部，且朝向该多个卡扣的中心轴线方向，多个卡扣的竖直凸起71用于阻止干燥剂6水平移动，多个卡扣的水平凸起72用于阻止干燥剂6的上下窜动，从而限定了干燥剂6的位置。盒身3与盒底4之间的连接形式可以设计为可拆卸连接，以方便干燥剂的放置与取出。
为了实现盒身3与盒底4的可拆卸连接，优选盒底4采用如图3所示结构，具体地，盒底4包括底座41以及设置于底座上表面的筒状凸起42，筒状凸起42围成的空腔为容纳腔5，筒状凸起42的 外壁设有外螺纹，如图7所示，盒身3的底部内壁设有可与该外螺纹配合的内螺纹。盒身3与盒底4之间的螺纹连接结构，可使盒底4的拆装过程简单、平稳。
具体地，止挡部22可以为下端连接于凸球面21边缘的圆柱形筒状结构，还可以为凸球面21周围设置的多个凸柱结构。相比于上述第一种方案，采用上述第二种方案，可通过合理设计相邻两个凸柱之间的间隙，具体地，将该间隙的宽度制作为小于角膜的最大宽度，大于用于夹取角膜的专用镊的宽度，以有效止挡角膜从凸球面21滑落，同时方便采用专用镊放置或者拿取角膜。因此，优选止挡部22为凸球面21周围设置的多个凸柱结构，例如可以制作为如图4所示结构，即止挡部22包括凸球面21周围设置的多个凸柱，相邻两凸柱之间具有一定的间隙，且间隙的宽度为1～3毫米，以有效止挡角膜从凸球面21滑落和褶皱变形，同时方便采用专用镊放置或拿取角膜。进一步地，由于角膜在移动运输过程中可能出现上下抖动，因此角膜保存和复水装置除了设置止挡部22以阻止角膜从凸球面21滑落之外，还可以合理设置盒盖1下表面与止挡部22上表面之间的距离，以阻止角膜从盒盖1下表面与止挡部22上表面之间掉出，具体地，止挡部22的上表面与盒盖1的下表面的距离设置为小于0.2毫米，以防止角膜在移动运输过程中由于上下抖动幅度过大，而从盒盖1下表面与止挡部22上表面之间掉出。为了保证角膜在凸球面上由止挡部围成的空间内发生颠覆，造成角膜正反方向调换，可以将上述凸柱的高度设置为小于角膜的直径，甚至更低，总之，通过上述凸柱的高度设置和止挡部22与盒盖1的间距设置可有效防止角膜发生颠覆，进而避免了对临床使用的影响。
为了保证止挡部22的最高处到盒盖1的下表面的距离较小，可以将止挡部22的位置设计的较高，使止挡部22的最高处靠近盒盖1的下表面，也即是，止挡部22的最高处高于盒体的上端面，也可反过来，将盒盖1的外壁的设计的较低，使盒盖1的下表面靠近止挡部22的最高处，也即是，止挡部22的最高处低于盒体的上端面。 当止挡部22的最高处高于盒体的上端面时，专用镊可以由止挡部22的侧面间隙伸入凸球面21区域，以方便采用专用镊放置或者夹取角膜，此时复水操作可以为：向盒身3内灌入水，采用专用镊将角膜从凸球面21上取下，放入盒身3的水内进行复水，一段时间后取出，即完成了角膜的复水操作；当止挡部22的最高处低于盒体的上端面时，在需要通过保存液保存角膜的情况下，盒身内保存液的液位可以达到完全淹没角膜的位置，从而对角膜进行有效的保存，除此之外，由于止挡部22的最高处低于盒体的上端面，因此复水操作的具体过程可以简化为：直接向盒身内灌入水使角膜浸泡在水中，一段时间后取出，即完成了角膜的复水，操作简单、方便。优选地，复水所用的水为满足临床使用的水，优选注射用水。
其中，止挡部22的最高处为多个凸柱的最高处，具体地，当多个凸柱的高度相等时，止挡部22的最高处为任一凸柱的顶端位置；当多个凸柱的高度不一致时，止挡部22的最高处为多个凸柱中最高凸柱的顶端位置。
当盒盖1的外壁向靠近止挡部22的方向凹陷时，凹陷部分11可以采用如图6所示的结构，即凹陷部分11的形状为正六边形，当然，凹陷部分11的形状还可以为圆形、椭圆形或者三角形等等，且凹陷部分11的位置可以在盒盖1的中心位置，也可以不在盒盖1的中心位置，在此不作限定。
具体地，角膜托架2可以采用如图7所示的结构，角膜托架2包括托板23和设置于托板上的凸台24，凸台24向靠近盒盖1的方向凸起，凸台24的上表面为用于放置角膜的凸球面21，托板23用于支撑设置于其上的凸台24，托板23的边缘与盒身3的内壁连接，托板23上开设有贯穿托板23上、下表面的通孔25，通孔25连通了托板23隔开的上下两个腔体，其中托板23以下的腔体为容纳腔5，托板23以上的腔体为角膜承载空间，用于放置角膜。
其中，托板23与盒身3之间的连接可以制作为可拆卸连接，还可以将托板23与盒身3制作为一体成型结构。当采用上述第一种方 案时，托板23与盒身3为两个不同的部件，需要分别制作，制作工艺较复杂。因此，为了避免上述问题，优选将托板23与盒身3制作为一体成型结构，例如可以制作为如图7所示的结构，从而简化了制作工艺。
另外，凸台24可以是圆柱型，也可以是长方体型，当然，凸台24还可以是其他形状，对此不作限定。
再者，由于托板23用于支撑设置于其上的凸台24，因此托板23受到来自凸台24的压力，为了防止托板23因受压而变形，需要合理设计托板23的结构，托板23可以采用圆锥形板结构，还可以采用平板结构。当托板23受到来自凸台的压力一定时，相比于平板结构，圆锥形板结构更不易变形，因此优选将托板23制作为圆锥形板结构，例如可以制作为如图7所示的圆锥形板结构。
为了使容纳腔5中存放的干燥剂能够均匀有效地对角膜进行干燥处理，优选通孔25在圆锥形板上均匀布置，且每一个通孔25的形状可以为长方形、圆形或者多边形等等，在此不作限定。
为了对角膜进行恒温保存，可在角膜保存和复水装置中设置保温结构，在图1所示的实施例中，可将盒体的侧壁制作为双层结构，盒体的内层侧壁和外层侧壁之间具有间隙，间隙中充满了空气，由于空气为热的不良导体，因此可以阻碍角膜保存和复水装置内部与外部之间的热量交换，从而实现了角膜的恒温保存。
参见图1，盒体的侧壁为双层结构，且两层侧壁之间的间隙内充满了空气，为了增大盒体侧壁的强度，在双层结构的间隙内可以设置加强筋，以防止盒体因受到外界的挤压而产生变形。
为了保证角膜保存和复水装置具有良好的密封性，可在盒身3与盒盖1的连接处设置第一密封圈8，并且在盒底4与盒身3的连接处设置第二密封圈9。具体地，可以围绕盒身3的外壁一周设置用于放置第一密封圈8的凹槽，且凹槽的深度小于第一密封圈8的直径，然后将第一密封圈8设置于所述凹槽内；可以围绕筒状凸起42的外壁一周设置用于放置第二密封圈9的凹槽，且凹槽的深度小 于第二密封圈9的直径，然后将第二密封圈9设置于所述凹槽内。由此，当盒身3与盒盖1连接后，第一密封圈8位于凹槽外的部分可被盒盖1的内侧壁挤压，从而实现盒身3与盒盖1的密封连接；同理，当盒底4与盒身3连接后，第二密封圈9位于凹槽外的部分可被盒身3的内侧壁挤压，从而实现盒底4与盒身3的密封连接。由此，可保证角膜保存和复水装置的整体密封性，从而防止外部的空气和杂质进入角膜保存和复水装置内部，对角膜产生影响。并且，当角膜保存和复水装置内部有保存液时，可以防止保存液流出。
为了更有效地保持角膜的结构形状，优选凸球面21的曲率与角膜的曲率相近，以使角膜与凸球面21能够完全地贴合，从而有效地防止了角膜变形。
由于盒身3和盒盖1之间、盒身3和盒底4之间的连接均为螺纹连接，因此在拆卸和安装时，需要对各部件进行转动，为了防止在转动过程中出现打滑现象，参见图8，优选在盒盖1的外壁以及盒底4的外壁分别设置第一防滑凸起12和第二防滑凸起43，以方便实现盒身3和盒盖1之间、盒身3和盒底4之间的拆卸和安装。
以上所述，仅为本发明的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，可轻易想到变化或替换，都应涵盖在本发明的保护范围之内。因此，本发明的保护范围应以所述权利要求的保护范围为准。

Claims (12)

  1. 一种角膜保存和复水装置，其特征在于，包括盒体和盒盖，所述盒体与所述盒盖可拆卸连接，所述盒体内设有用于承载角膜的角膜托架，所述角膜托架用于放置角膜的表面为凸球面，所述凸球面周围设有用于防止角膜掉出的止挡部。
  2. 根据权利要求1所述的角膜保存和复水装置，其特征在于，所述盒体包括盒身和位于盒身底部的盒底，所述角膜托架位于所述盒底上方，所述盒底与所述角膜托架之间设有容纳腔，所述盒盖用于盖住盒体，所述角膜托架与所述盒盖之间具有角膜承载空间，所述容纳腔与所述角膜承载空间连通。
  3. 根据权利要求2所述的角膜保存和复水装置，其特征在于，所述容纳腔内设有用于固定干燥剂的限位结构，所述盒身与所述盒底可拆卸连接。
  4. 根据权利要求3所述的角膜保存和复水装置，其特征在于，所述盒底包括底座以及设置于所述底座上表面的筒状凸起，所述筒状凸起围成的空腔为所述容纳腔，所述筒状凸起的外壁设有外螺纹，所述盒身的底部内壁设有与所述外螺纹配合的内螺纹。
  5. 根据权利要求1所述的角膜保存和复水装置，其特征在于，所述止挡部包括围绕所述凸球面一周设置的多个凸柱，相邻两凸柱之间具有间隙，所述间隙的宽度为1～3毫米。
  6. 根据权利要求1所述的角膜保存和复水装置，其特征在于，所述止挡部的最高处与所述盒盖的下表面的距离小于0.2毫米。
  7. 根据权利要求1所述的角膜保存和复水装置，其特征在于，所述盒体的上端面高于所述止挡部的最高处，所述盒盖的外壁向靠近所述止挡部的方向凹陷。
  8. 根据权利要求1～7中任一项所述的角膜保存和复水装置，其特征在于，所述角膜托架包括托板和设置于所述托板上的凸台，所述凸台向靠近所述盒盖的方向凸起，所述凸台的上表面为用于放置角膜的所述凸球面，所述托板的边缘与所述盒身的内壁连接，所述托板上开设有贯穿托板的通 孔。
  9. 根据权利要求8所述的角膜保存和复水装置，其特征在于，所述托板为圆锥形板，所述通孔在所述圆锥形板上均匀布置。
  10. 根据权利要求1～7中任一项所述的角膜保存和复水装置，其特征在于，所述盒体的侧壁为双层，双层之间具有间隙，所述间隙内设有加强筋。
  11. 根据权利要求4所述的角膜保存和复水装置，其特征在于，所述盒身顶部外壁设有外螺纹，所述盒盖的侧部内壁设有与所述外螺纹配合的内螺纹，所述盒身与盒盖的螺纹连接处设置有第一密封圈，所述盒身与盒底的连接处设置有第二密封圈。
  12. 根据权利要求1～7中任一项所述的角膜保存和复水装置，其特征在于，所述凸球面的曲率与角膜的曲率相近。
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