WO2017012764A1 - Crème dentifrice à inactivation réduite du fluorure - Google Patents

Crème dentifrice à inactivation réduite du fluorure Download PDF

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Publication number
WO2017012764A1
WO2017012764A1 PCT/EP2016/062606 EP2016062606W WO2017012764A1 WO 2017012764 A1 WO2017012764 A1 WO 2017012764A1 EP 2016062606 W EP2016062606 W EP 2016062606W WO 2017012764 A1 WO2017012764 A1 WO 2017012764A1
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WO
WIPO (PCT)
Prior art keywords
weight
calcium
ppm
fluoride
mouth
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Application number
PCT/EP2016/062606
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German (de)
English (en)
Inventor
Thomas Welss
Nicole Duschek
Wilfried Howorka
Kristin Miehlich
Original Assignee
Henkel Ag & Co. Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henkel Ag & Co. Kgaa filed Critical Henkel Ag & Co. Kgaa
Priority to EP16726604.8A priority Critical patent/EP3324918A1/fr
Publication of WO2017012764A1 publication Critical patent/WO2017012764A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds

Definitions

  • the present invention relates to oral and dental care and cleaning compositions containing fluoride and calcium salt (s).
  • the aforementioned agent has improved storage stability and anti-enamel activity.
  • Enamel consists mainly of calcium hydroxyapatite of the formula Caio (PO 4) 6 (OH) 2, which may be partially substituted with anions such as carbonates or fluorides and cations such as zinc or magnesium. Furthermore, enamel may also contain non-apatitic mineral phases such as octacalcium phosphate and calcium carbonate.
  • the loss of tooth enamel can be caused by caries.
  • Caries are local cavities caused by the action of bacterial acids on the enamel.
  • the formation of bacterial acids is carried out by microorganisms, which are contained in the surrounding biofilm (plaque) and convert carbohydrates from food to acids.
  • the action of the bacterial acids dissolves calcium phosphates from the enamel and demineralises it continuously. This demineralization eventually leads to the formation of local cavities of the enamel and the tooth in the form of caries.
  • the loss of enamel can be caused by non-bacterial acids, which lead to a surface erosion (also called erosion) of the enamel.
  • the action of acids on enamel leads to a demineralization, which results in a softening of the tooth surface as well as in a decrease of the mineral density and tooth hardness.
  • the demineralized enamel regenerates through the saliva containing remineralizing calcium and phosphate compounds.
  • salivation results in washout of the acid and an increase in pH at which minerals can deposit in the enamel.
  • fluoride-containing compounds are used to prevent erosion of the enamel and the formation of decay.
  • fluoride can not completely prevent the loss of enamel and caries.
  • Bivalent cations such as calcium, are other important building blocks of natural remineralization processes. To aid this natural process, a variety of dentifrice formulations contain an additional source of calcium or other bivalent cations.
  • the desirable use of calcium salts in fluoride-containing oral and dental care and cleaning agents can therefore lead to inactivation of the fluoride, the so-called "fluoride depletion", especially during prolonged storage of the corresponding products.
  • the present invention relates to oral and dental care and cleaning compositions, containing - based on their weight - a) 500 to 1600 ppm fluoride, calculated as F ⁇ ,
  • oral and dental care compositions and “oral and dental cleansing compositions” are understood as meaning oral and dental powders, oral and toothpastes, liquid mouth and tooth creams and oral and dental gels. Particularly preferred are toothpastes and liquid dentifrices, which are present as more or less flowable or plastic toothpastes, as used for cleaning the teeth using a toothbrush.
  • the compositions according to the invention contain 500 to 1600 ppm of fluoride, corresponding to 0.05 to 0, 16 wt .-% F ⁇ .
  • Particularly preferred oral and dental care and cleaning compositions of the invention are characterized by having 1225 to 1575 ppm, preferably 1250 to 1550 ppm, more preferably 1275 to 1525 ppm, even more preferably 1300 to 1500 ppm, even more preferably 1325 to 1475 ppm and especially 1350 to 1450 ppm fluoride.
  • This may be provided in the form of inorganic fluoride salts (sodium fluoride, stannous fluoride, sodium monofluorophosphate, etc.), but amine fluorides such as olaflur are also suitable. Regardless of the type of fluoride compound used, the amount used is calculated as F ⁇ .
  • 1% by weight of sodium monofluorophosphate corresponds to 0.132% by weight of fluoride, corresponding to approximately 1320 ppm of fluoride, so that preferred agents according to the invention are characterized from 0.38 to 1.2% by weight, preferably from 0.4 to 1.5% by weight, more preferably from 0.5 to 1.1% by weight, even more preferably from 0 to 1% by weight , 6 to 1, 05 wt .-%, and in particular 0.75 to 1 wt .-% sodium monofluorophosphate.
  • the oral and dental care and cleansing compositions of the present invention contain from 0.001 to 5 weight percent calcium glycerophosphate, i. 0.001 to 5 wt .-% of at least one calcium salt of at least one glycerophosphoric acid.
  • the glycerophosphoric acid is a dibasic acid which occurs in two isomeric forms, depending on whether the phosphoric acid group is bound to a terminal or the medial OH group of glycerol.
  • the form in which the phosphoric acid moiety is bonded to a terminal OH group of the glycerol is also referred to as an alpha isomer
  • the form in which the phosphoric acid moiety is bonded to the medial OH group of the glycerol is also referred to as a beta isomer.
  • the alpha isomer is additionally optically active and occurs in the two enantiomeric forms sn-glycerol-1-phosphoric acid and sn-glycerol-3-phosphoric acid.
  • glycerol derivatives The prefix sn for glycerol derivatives is "stereospecifically numbered" and requires that the 2-hydroxy group be pointing to the left in the Fischer projection used above. Glycerol-2-phosphate is not optically active. The glycerophosphoric acids are about as strong as phosphoric acid.
  • the use of the alpha-isomer is preferred, regardless of which of the two enantiomers is used. If the use of enantiomerically pure compounds is desired, the calcium salt of sn-glycerol-3-phosphoric acid is preferably used.
  • oral and dental care and cleaning compositions according to the invention which contain calcium salts of the glycerophosphoric acids of the formulas (Ia) and (Ib) are preferred
  • Particularly preferred mouth and tooth care and cleaning compositions according to the invention are characterized in that the weight ratio of the calcium salts of the formulas (Ia) to (Ib) is above 50:50, preferably above 60:40, particularly preferably above 70:30 and in particular above 80:20.
  • Preferred oral and dental care and cleaning compositions according to the invention contain - based on their weight - 0.01 to 2.5 wt .-%, preferably 0.25 to 2.0 wt .-%, particularly preferably 0.05 to 1, 0 wt .-%, more preferably 0.075 to 0.75 wt .-% and in particular 0.1 to 0.5 wt .-% calcium glycerophosphate.
  • the agents according to the invention may contain further calcium salts.
  • calcium ion sources are also calcium hydrogen phosphate dihydrate, CaHPO ⁇ hbO or the sulfate or the salts of organic acids.
  • Particularly preferred mouth and dental care and cleaning agents according to the invention are characterized in that they additionally contain further calcium salts, preferably one or more representatives from the group calcium carbonate, calcium hydrogen phosphate dihydrate, calcium sulfate, calcium lactate, calcium citrate, calcium gluconate, wherein the further (n ) Calcium salt (s) particularly preferably in amounts of 0.001 to 5 wt .-%, preferably from 0.0025 to 4 wt .-%, more preferably from 0.005 to 3 wt .-%, particularly preferably from 0.0075 to 2 wt .-%, still more preferably from 0.01 to 1 wt .-% and in particular from 0.015 to 0.5 wt .-%, calculated as Ca 2+ , in each case based on the total Means are included.
  • further calcium salts preferably one or more representatives from the group calcium carbonate, calcium hydrogen phosphate dihydrate, calcium sulfate, calcium lactate, calcium citrate, calcium gluconate, where
  • Mouth and dental care and cleansing compositions according to the invention which contain calcium hydrogen phosphate dihydrate, CaHPO 3 hhO as the calcium salt have distinct advantages over other agents. Accordingly, oral and dental care and cleaning compositions according to the invention are preferred which contain from 0.25 to 7.5% by weight, preferably from 0.5 to 7.0% by weight, particularly preferably from 1.0 to 6.0% by weight. %, more preferably 2.0 to 5.0 wt .-% and in particular 3.5 to 4.5 wt .-% calcium hydrogen phosphate dihydrate.
  • the oral and dental care and cleansing compositions of the present invention contain from 0.5% to 20% by weight of erythritol (erythritol or (2S, 3R) butane-1,2,3,4-tetrol).
  • erythritol erythritol or (2S, 3R) butane-1,2,3,4-tetrol.
  • high amounts of erythritol to achieve the effect of the invention are not necessary, so that preferred oral and dental care and cleaning agent - based on their weight - 0.75 to 17.5 wt .-%, preferably 1 to 15 wt. %, more preferably 1, 25 to 12.5 wt .-% and in particular 1, 5 to 10 wt .-% erythritol.
  • the agents according to the invention may contain further sugar alcohols. Interestingly, these have no effect on "fluoride depletion,” but prevent toothpaste from drying out, and serve as a matrix in so-called liquid tooth creams with flowable rheology and are used in higher amounts.
  • oral and dental care and cleaning compositions according to the invention are preferred which - based on their weight - 0.5 to 60 wt .-%, preferably 0.75 to 55 wt .-%, particularly preferably 1 to 50 wt .-% and in particular 2 to 40 wt .-% of at least one polyhydric alcohol from the group sorbitol and / or glycerol and / or 1, 2-Propylenglycol .-% or mixtures thereof.
  • sorbitol is preferred.
  • mixtures of two of the three or all three may be preferred.
  • a mixture of glycerol, sorbitol and 1,2-propylene glycol in a weight ratio of 1: (0.5-1) :( 0.1-0.5) has proved to be particularly advantageous.
  • suitable further polyhydric alcohols are those having at least 2 OH groups, preferably mannitol, xylitol, polyethylene glycol, polypropylene glycol and mixtures thereof. Among these compounds, those having 2 to 12 OH groups, and especially those having 2, 3, 4, 5, 6 or 10 OH groups are preferred.
  • the (n, n + 1) or (n, n + 2) - diols with non-terminal OH groups can also be used.
  • polyhydroxy compounds having 2 OH groups are also the polyethylene and polypropylene glycols.
  • polyhydric alcohols may, for. B. xylitol, propylene glycols, polyethylene glycols, especially those having average molecular weights of 200-800 are used.
  • sorbitol particularly preferred is the use of sorbitol, so that agents which contain no other polyhydric alcohols other than sorbitol are particularly preferred.
  • erythtritol c) and calcium glycerophosphate b) are characterized in that the weight ratio of erythtritol c) to calcium glycerophosphate b) (calculated as CsHzCaOeP) at> 5: 1, preferably at> 7.5: 1, more preferably at > 10: 1, more preferably> 15: 1, even more preferably> 20: 1 and especially> 25: 1.
  • the agents according to the invention contain, in addition to calcium glycerophosphate b), further calcium salt (s), it is preferred that erythritol be used in excess of calcium. Mouth and dental care and cleaning compositions according to the invention are preferred in which the weight ratio of erythritol c) to calcium salt (s) (calculated as Ca 2+ ) is> 5: 1, preferably> 10: 1, more preferably> 25 : 1, more preferably> 50: 1, even more preferably> 75: 1 and especially> 100: 1.
  • compositions according to the invention may additionally contain at least one polishing agent.
  • a polishing agent are in principle all known for toothpastes contain friction body.
  • suitable polishing agent components are therefore silicic acids, aluminum hydroxide, aluminum oxide, sodium aluminum silicates, organic polymers or mixtures of such friction bodies.
  • the total content of polishing agents is preferably in the range of 5 to 50% by weight of the dentifrice.
  • Agents preferred according to the invention contain polishing agents within narrower ranges.
  • Suitable silicas are e.g. Gel silicas, hydrogel silicas and precipitated silicas.
  • Gel silicas are prepared by reacting sodium silicate solutions with strong, aqueous mineral acids to form a hydrosol, aging to the hydrogel, washing and drying. If the drying takes place under mild conditions to water contents of 15 to 35 wt .-%, the so-called hydrogel silicas are obtained. Drying to water contents below 15% by weight results in an irreversible shrinkage of the previously loose structure of the hydrogel to the dense structure of the so-called xerogel.
  • a second, particularly suitable group of silica polishes are the precipitated silicas. These are obtained by precipitation of silica from dilute alkali silicate solutions by addition of strong acids under conditions in which aggregation to the sol and gel can not occur.
  • Suitable methods for preferably suitable is a precipitated silica having a BET surface area of 15 to 10 m 2 / g, a particle size of 0.5 to 20 ⁇ m, where at least 80% by weight of the primary particles are below 5 ⁇ m, and one Viscosity in 30% glycerol-water (1: 1) dispersion of 30 - 60 Pa.s (20 ° C) in an amount of 10 - 20 wt .-% of the toothpaste.
  • Particularly suitable precipitated silicas of this type have rounded corners and edges and are commercially available under the trade name ® Sident 12 DS (DEGUSSA).
  • silicas having a particle size of less than 5 ⁇ m, preferably at least 3% by weight Silica with a particle size of 1 - 3 ⁇ .
  • thickening silicas with a BET surface area of 150-250 m 2 / g for example, the commercially available product ® Sident 22S.
  • Aluminum oxide in the form of slightly calcined alumina with a content of aluminum oxide and aluminum oxide in an amount of about 1-5% by weight may also be present as a further polishing component.
  • Such a suitable alumina is available under the trade designation "Polianton earth P10 finest" (Giulini Chemie).
  • polishing agent As a polishing agent are all further known for toothpastes friction body such.
  • oral and dental care and cleaning compositions according to the invention are preferred which additionally comprise cleaning bodies, preferably silicic acids, aluminum hydroxide, aluminum oxide, calcium pyrophosphate, chalk, dicalcium phosphate dihydrate (CaHPC.sub.2H.sub.2O), sodium aluminum silicates, in particular zeolite A, organic polymers, in particular polymethacrylates or mixtures this friction body, preferably in amounts of from 1 to 30% by weight, preferably from 2.5 to 25% by weight and in particular from 5 to 22% by weight, in each case based on the total agent.
  • cleaning bodies preferably silicic acids, aluminum hydroxide, aluminum oxide, calcium pyrophosphate, chalk, dicalcium phosphate dihydrate (CaHPC.sub.2H.sub.2O), sodium aluminum silicates, in particular zeolite A, organic polymers, in particular polymethacrylates or mixtures this friction body, preferably in amounts of from 1 to 30% by weight, preferably from 2.5 to 25% by weight and in particular from 5 to 22% by
  • compositions according to the invention contain, based on their weight, from 1 to 30% by weight of precipitated silica (s) having a specific surface area according to ISO 5794-1, Annex D of ⁇ 55 m 2 / g.
  • the precipitated silicas having corresponding specific surface areas are used within narrower ranges of amounts, and particularly preferably precipitated silicas are used which have even lower specific surface areas according to ISO 5794-1, Annex D.
  • Preferred oral and dental care and cleaning compositions according to the invention contain from 2.5 to 25% by weight, preferably from 5 to 20% by weight, more preferably from 7.5 to 17.5% by weight, more preferably from 8.0 to 15.0 wt .-% and in particular 10.0 to 13.0 wt .-% precipitated silica (s) having a specific surface area according to ISO 5794-1, Annex D of ⁇ 55 m 2 / g.
  • Particularly preferred mouth and dental care and cleaning agents according to the invention are characterized in that all precipitated silica contained in the middle have a specific surface area according to ISO 5794-1, Annex D of ⁇ 53 m 2 / g, preferably of ⁇ 51 m 2 / g , more preferably of ⁇ 49 m 2 / g and in particular of ⁇ 47 m 2 / g.
  • Surface-active substances can also be used in the agents according to the invention. They serve, for example, in toothpastes to support the cleaning action and, if desired, also for the development of foam in tooth brushing and for stabilizing the polishing body dispersion in the carrier and are usually used in an amount of 0.1-5 wt .-%.
  • Suitable surfactants are, for. B. linear sodium alkyl sulfates having 12-18 C atoms in the alkyl group. These substances additionally have an enzyme-inhibiting effect on the bacterial metabolism of the dental plaque.
  • Other suitable surfactants are alkali metal salts, preferably sodium salts of alkylpolyglycol ether sulfate with 12-16 C atoms in the linear alkyl group and 2-6 glycol ether groups in the molecule, of linear alkane (C 12- cis) sulfonate, of Sulfobernsteinklamonoalkyl (Ci2-Ci8) esters of sulfated fatty acid monoglycerides, sulfated fatty acid alkanolamides, sulfoacetic acid alkyl (Ci2-Ci6) esters, acylsarcosines, acyl taurides and Acylisothionaten each having 8-18 C atoms in the acyl group.
  • zwitterionic, ampholytic and nonionic surfactants are suitable, for.
  • mouth and dental care and cleaning compositions according to the invention which - based on their weight - less than 5 wt .-%, preferably less than 4 wt .-%, more preferably less than 3 wt .-% and in particular less than 2 wt .-% surfactant (s), according to the invention particularly preferred.
  • preferred oral and dental care and cleaning compositions according to the invention are characterized in that they contain less than 2% by weight, preferably less than 1% by weight, more preferably less than 0.5% by weight and in particular less than 0, 1 wt .-% anionic (s) surfactant (s), preferred agents being free of anionic surfactants.
  • Preferred surfactant-containing oral and dental care and cleaning compositions according to the invention contain from 0.1 to 5% by weight, preferably from 0.25 to 4% by weight, particularly preferably from 0.5 to 3.0% by weight, more preferably 0, 75 to 2.0 wt .-% and in particular 1, 0 to 1, 5 wt .-% amphoteric surfactant (s).
  • Particularly preferred oral and dental care and cleaning agents according to the present invention contain from 0.1 to 5% by weight, preferably from 0.2 to 4% by weight, particularly preferably from 0.25 to 3% by weight, more preferably 0, 3 to 2 wt .-% and in particular 0.4 to 0.8 wt .-% cocoamidopropyl betaine.
  • compositions according to the invention can also additionally other wound-healing and anti-inflammatory substances, eg. B. agents for gingivitis included.
  • B. agents for gingivitis included Such substances may, for. B. be selected from allantoin, azulen, chamomile extracts, tocopherol, panthenol, bisabolol, sage extracts.
  • Oral and dental care and cleaning agents may e.g. also contain substances that are effective against plaque and / or tartar.
  • Anti-calculus substances may be, for example, chelating agents such.
  • chelating agents such as ethylenediaminetetraacetic acid and its sodium salts
  • pyrophosphate salts such as water-soluble dialkali or tetraalkali metal pyrophosphate salts, e.g. Na4P20, K4P2O7, Na2K2P2Ü7, Na2H2P207 and K2H2P2O7 or polyphosphate salts, e.g. B. from water-soluble Alkalimethalltripolyphosphaten as sodium tripolyphosphate and potassium tripolyphosphate can be selected.
  • preferred oral and dental care and cleaning agents are characterized in that they additionally phosphate (s), preferably alkali metal phosphate (s) and in particular sodium tripolyphosphate, preferably in amounts of 1 to 10 wt .-%, particularly preferably from 2 to 8 wt .-% and in particular from 3 to 7 wt .-%, each based on the total agent included.
  • phosphate preferably alkali metal phosphate (s) and in particular sodium tripolyphosphate
  • a consistency regulator serve z.
  • natural and / or synthetic water-soluble polymers such as alginates, carrageenan, tragacanth, starch and starch ethers, cellulose ethers such. Carboxymethylcellulose (Na salt), hydroxyethylcellulose, methylhydroxypropylcellulose, guar, acacia, agar, xanthan gum, succinoglycan gum, locust bean gum, pectins, water-soluble carboxyvinyl polymers (e.g., Carbopo D types), polyvinyl alcohol, polyvinylpyrrolidone, Polyethylene glycols, in particular those having molecular weights of 1 500-1 000 000.
  • z. B phyllosilicates
  • montmorillonite clays colloidal thickened silicas such.
  • airgel silicas fumed silicas or finely ground precipitated silicas.
  • viscosity-stabilizing additives from the group of cationic, zwitterionic or ampholytic nitrogenous surfactants, hydroxypropyl-substituted hydrocolloids or polyethylene glycol / polypropylene glycol copolymers having an average molecular weight of 1000 to 5000 or a combination of the compounds mentioned in the toothpastes.
  • Xanthan gum or xanthan gum is a natural, renewable resource and is excreted as an anionic polysaccharide by the bacterium Xanthomonas campestris.
  • the molecular weight of the xanthan gum used is preferably from 2 0 6 to 20 10 6 g / mol.
  • Particularly preferred mouth and dental care and cleaning compositions according to the invention contain - based on their weight - 0, 15 to 5 wt .-%, preferably 0.2 to 4 wt .-%, particularly preferably 0.25 to 2.5 parts by weight. %, more preferably 0.3 to 1, 5 wt .-%, even more preferably 0.35 to 1, 25 wt .-% and in particular 0.4 to 1 wt .-% xanthan.
  • compositions according to the invention can be improved, for example, by adding aroma oils and sweeteners in their organoleptic properties.
  • aroma oils all the natural and synthetic flavors customary for oral and dental care products can be used.
  • Natural flavors can be contained both in the form of natural essential oils isolated from drugs and the individual components isolated therefrom.
  • Suitable flavors are e.g. Whistle oil, spearmint oil, eucalyptus oil, aniseed oil, fennel oil, caraway oil, menthyl acetate, cinnamaldehyde, anethole, vanillin, thymol and mixtures of these components. in the
  • Suitable sweeteners are e.g. Saccharin sodium, sodium cyclamate, sucrose, lactose, meltose, fructose.
  • Solvents and solubilizers e.g. lower monohydric or polyhydric alcohols or ethers, e.g. Ethanol, 1, 2-propylene glycol, diethylene glycol or butyl diglycol
  • Titanium dioxide e.g. Titanium dioxide
  • Buffer substances e.g. primary, secondary or tertiary alkali phosphates or citric acid / Na citrate
  • wound healing or anti-inflammatory agents e.g. Allantoin, urea, azulene,
  • vitamins such as e.g. Ascorbic acid, biotin, tocopherol or rutin
  • Mineral salts such as manganese, zinc or magnesium salts.
  • the toothpaste E according to the invention and the comparative example V (absence of erythritol) were prepared and samples of the respective toothpastes were stored for 6 or 12 weeks at room temperature (20 ° C.), at 40 ° C. and at 45 ° C. (long-term storage).

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
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  • Inorganic Chemistry (AREA)
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  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

Produits pour l'hygiène bucco-dentaire contenant - exprimés par rapport au poids - de 500 à 1600 ppm de fluorure, mesuré en tant que F-, de 0,001 à 5 % en poids de glycérophosphate de calcium, et de 0,5 à 20 % en poids d'érythritol. Ces produits présentent une protection améliorée contre l'érosion de l'émail dentaire et l'apparition de caries, même en cas d'entreposage prolongé.
PCT/EP2016/062606 2015-07-21 2016-06-03 Crème dentifrice à inactivation réduite du fluorure WO2017012764A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP16726604.8A EP3324918A1 (fr) 2015-07-21 2016-06-03 Crème dentifrice à inactivation réduite du fluorure

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102015213724.4A DE102015213724A1 (de) 2015-07-21 2015-07-21 Zahncreme mit verringerter Fluoridinaktivierung
DE102015213724.4 2015-07-21

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Publication Number Publication Date
WO2017012764A1 true WO2017012764A1 (fr) 2017-01-26

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PCT/EP2016/062606 WO2017012764A1 (fr) 2015-07-21 2016-06-03 Crème dentifrice à inactivation réduite du fluorure

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020174914A1 (fr) * 2019-02-28 2020-09-03 花王株式会社 Composition pour cavité buccale
TWI842814B (zh) 2019-02-28 2024-05-21 日商花王股份有限公司 口腔用組合物

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000191486A (ja) * 1998-12-25 2000-07-11 Kao Corp 口腔用組成物
WO2010068359A1 (fr) * 2008-12-11 2010-06-17 3M Innovative Properties Company Particules de phosphate de calcium traitées en surface pour soins buccaux et compositions dentaires
JP2011126788A (ja) * 2009-12-15 2011-06-30 Lion Corp 口腔用組成物
WO2013094504A1 (fr) * 2011-12-21 2013-06-27 ライオン株式会社 Composition orale

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000191486A (ja) * 1998-12-25 2000-07-11 Kao Corp 口腔用組成物
WO2010068359A1 (fr) * 2008-12-11 2010-06-17 3M Innovative Properties Company Particules de phosphate de calcium traitées en surface pour soins buccaux et compositions dentaires
JP2011126788A (ja) * 2009-12-15 2011-06-30 Lion Corp 口腔用組成物
WO2013094504A1 (fr) * 2011-12-21 2013-06-27 ライオン株式会社 Composition orale

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020174914A1 (fr) * 2019-02-28 2020-09-03 花王株式会社 Composition pour cavité buccale
JP2020143041A (ja) * 2019-02-28 2020-09-10 花王株式会社 口腔用組成物
CN113507966A (zh) * 2019-02-28 2021-10-15 花王株式会社 口腔用组合物
JP7281423B2 (ja) 2019-02-28 2023-05-25 花王株式会社 口腔用組成物
CN113507966B (zh) * 2019-02-28 2024-01-30 花王株式会社 口腔用组合物
TWI842814B (zh) 2019-02-28 2024-05-21 日商花王股份有限公司 口腔用組合物

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EP3324918A1 (fr) 2018-05-30

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