WO2016062450A1 - Agents de soins et de nettoyage buccal et dentaire avec combinaison d'agents de polissage améliorée - Google Patents
Agents de soins et de nettoyage buccal et dentaire avec combinaison d'agents de polissage améliorée Download PDFInfo
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- WO2016062450A1 WO2016062450A1 PCT/EP2015/070557 EP2015070557W WO2016062450A1 WO 2016062450 A1 WO2016062450 A1 WO 2016062450A1 EP 2015070557 W EP2015070557 W EP 2015070557W WO 2016062450 A1 WO2016062450 A1 WO 2016062450A1
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- precipitated silica
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Definitions
- the invention relates to oral and dental care products with a synergistic combination of active ingredients for gentle and effective cleaning of the teeth.
- Dentifrices are available in various forms on the market and are primarily used to clean the tooth surface and to prevent tooth and gum disease. They usually contain a combination of polishes, humectants, surfactants, binders, flavorings and fluoride-containing and antimicrobial agents. In addition to toothpowder, which play a minor role because of their increased abrasiveness, dentifrices are mainly offered in paste, cream and translucent or transparent gel form. Liquid or liquid toothpastes and mouthwashes have also become increasingly important in recent years.
- Tooth whitening Another way to whiten the teeth is to effectively remove plaque that makes the teeth look darker.
- This method of tooth whitening is also described as "natural whitening.”
- a high cleaning performance is best achieved by cleaning bodies, for example, silica, alumina, or calcium carbonate in combination with a surfactant
- toothpastes with an effective system of one or more cleaning bodies are also common high abrasiveness, thus leading to a certain, albeit very slight, abrasion of the tooth surface, which may be disadvantageous if the enamel of a tooth is already thin, as is the case with persons with sensitive teeth Persons with sensitive teeth also have exposed tooth necks, ie parts of the tooth in the immediate vicinity of the gum, where no enamel is present as a protective layer and the underlying dentin is exposed.
- friction bodies that are suitable for use in toothpastes. These friction bodies can be characterized by their physical parameters, such as particle size, oil absorption capacity, BET surface area, bulk and tamped density, etc.
- the RDA test Radioactive Dentine Abrasion Test
- Rubbers with high RDA values tend to be more abrasive, which can cause problems, especially for people with sensitive teeth.
- Friction bodies with low RDA values may possibly have disadvantages in effectively cleaning the teeth compared with other friction bodies.
- the present invention relates in a first embodiment to oral and dental care and cleaning compositions containing, based on their weight, a) 5 to 20% by weight of at least one precipitated silica A, which has the following properties:
- a weight average particle size (Malvern Mastersizer Model X with a 45 mm lens and an MS-5 sample presentation unit) of 8 to 13 ⁇ ; b. a BET surface area (standard nitrogen adsorption method of Brunauer, Emmett and Teller, using a single point method with a Sorpty 1750 instrument of the Carlo Erba Company, Italy) of 40 to 60 m 2 / g; c. an RDA value (determined according to Journal of Dental Research 55 (4) 563, 1976) of 50 to 120
- a weight average particle size (Malvern Mastersizer Model X with a 45 mm lens and a MS-5 sample presentation unit) of 8 to 10 ⁇
- Oral and dental care as well as oral and dental cleaning agents in the context of the invention are preparations that can be used for cleaning and care of the oral cavity and teeth.
- preferred agents according to the invention are mouthwashes and toothpowder, mouth and toothpastes, (semi-) liquid mouth and tooth creams and oral and dental gels.
- suitable are toothpastes and liquid dentifrices.
- the oral and dental care and cleaning agents for example in the form of toothpastes, liquid toothpastes, toothpowder or possibly also as gum, z. B. as chewing gum, present.
- they are present as more or less flowable or plastic toothpastes, as they are used for cleaning the teeth using a toothbrush.
- compositions according to the invention contain, based on their weight, 5 to 20% by weight of at least one precipitated silica A.
- This precipitated silica A has a weight-average particle size (Malvern Mastersizer Model X with a 45 mm lens and an MS-5 sample presentation unit) of 8 to 13 ⁇ m.
- the weight average particle size of the silica is determined using a Malvern Mastersizer Model X with a 45 mm lens and an MS-5 sample presentation unit.
- This instrument manufactured by Malvern Instruments, Malvern, Worcestershire, uses the principle of Fraunhoffer refraction, using a low energy He / Ne laser. Prior to measurement, the sample is dispersed in water using ultrasound for 7 minutes to form an aqueous dispersion.
- the Malvern Mastersizer measures the weight-based particle size distribution of the silica.
- the weight-average particle size (dso;) or 50-percentile, the 10-percentile (dio;), and the 90-percentile (dgo;) are easily obtained from the data generated by the instrument.
- precipitated silica A products which have an even narrower particle size distribution.
- Particularly preferred oral and dental care and cleaning agents according to the invention are characterized in that the precipitated silica A has a weight-average particle size of 9 to 12 ⁇ , preferably from 9.5 to 1 1, 5 ⁇ and in particular from 10 to 1 1 ⁇ .
- the measurement conditions are room temperature (25 ° C.) and normal pressure (1013.25 mbar).
- Precipitated silica A also has a BET surface area (standard nitrogen adsorption method from Brunauer, Emmett and Teller, using a single point method with a Sorpty 1750 instrument from the Carlo Erba Company, Italy) of 40 to 60 m 2 / g.
- the surface area is determined using the standard nitrogen adsorption methods of Brunauer, Emmett and Teller (BET) using a single point method with a Sorpty 1750 instrument supplied by Carlo Erba Company of Italy.
- BET Brunauer, Emmett and Teller
- the precipitated silica A moreover has an RDA value (determined according to Journal of Dental Research 55 (4) 563, 1976) of 50 to 120.
- the procedure is consistent with the method of determining dentifrice abrasiveness recommended by the American Dental Association.
- drawn human teeth are irradiated with a neutron flux and subjected to a standard cleaning procedure.
- the radioactive phosphorus removed from the dentin in the roots is used as an index of the abrasiveness of the dentifrice tested.
- a hostssaufschlämmung containing 10 g of calcium pyrophosphate in 50 cm 3 (ml) containing a 0.5% aqueous solution of sodium carboxymethyl cellulose is also measured and the RDA of this mixture is arbitrarily taken as the 100th
- the precipitated silica to be tested is prepared as a suspension of 6.25 g in 50 cm 3 (ml) of a 0.5% aqueous solution of sodium carboxymethylcellulose and used in the same cleaning procedure.
- precipitated silicas A which have a certain DBP absorption give the products according to the invention an even more pleasant "feel", ie a more pleasant product feel during use Therefore, characterized in that the precipitated silica A is a DBP absorption (ASTM Spatel method American Society Of Test Material Standards D, 281) of 100 to 200 cm 3 / 100g, preferably from 1 10 to 150 cm 3 / 100g, more preferred from 1 15 to 140 cm 3 / 100g and in particular from 120 to 130 cm 3 / 100g.
- DBP absorption ASTM Spatel method American Society Of Test Material Standards D, 281
- the test is based on the principle of mixing linseed oil (oil absorption) or dibutyl phthalate (DBP absoption) with a silica by wiping with a spatula on a smooth surface until a stiff, putty-like paste has formed which does not break or disintegrate when she is cut with a spatula.
- the volume of oil used is then inserted into the following equation:
- the compositions of the invention contain - based on their weight - 0.1 to 10 wt .-% of at least one further precipitated silica B. This differs from the precipitated silica A in particular in the RDA value, because it has according to the invention an RDA value (determined according to Journal of Dental Research 55 (4) 563, 1976) from 125 to 150.
- the precipitated silicas A and B additionally differ in their BET surface area (standard nitrogen adsorption methods from Brunauer, Emmett and Teller, using a single point method with a Sorpty 1750 instrument from the Carlo Erba Company, Italy), because the precipitated silica A has a BET surface area of 40 to 60 m 2 / g, while and the precipitated silica B has a BET surface area of 65 to 80 m 2 / g.
- the precipitated silicas A and B preferably also differ in terms of their weight-average particle size (Malvern Mastersizer Model X with a 45 mm lens and an MS-5 sample presentation unit), wherein it is preferred that the precipitated silica A has a weight-average particle size of 10.5 ⁇ 0.4 ⁇ and the precipitated silica B has a weight-average particle size of 9 ⁇ 0.6 ⁇ .
- precipitated silicas B which have a certain oil absorption give the products according to the invention an even more pleasant "feel", ie a more pleasant product feel during use characterized in that the precipitated silica B has an oil absorption capacity (ASTM Spatel method American Society of Test Material Standards D, 281) of 40 to 120 cm 3 / 100g, preferably from 50 to 1 10 cm 3 / 100g, more preferably from 60 to 100 cm 3 / 100g and in particular from 70 to 90 cm 3 / 100g ..
- oil absorption capacity ASTM Spatel method American Society of Test Material Standards D, 281
- Preferred agents according to the invention contain both the precipitated silica A and the precipitated silica B within narrower quantitative ranges, which further optimizes the reduction in abrasiveness and the increase in the cleaning performance.
- Preferred oral and dental care and cleaning agents according to the invention are characterized in that they contain, based on their weight, from 6 to 18% by weight, preferably from 7 to 16% by weight, especially preferably 8 to 14 wt .-%, most preferably 9 to 13 wt .-% and in particular 10 to 12 wt .-% precipitated silica A included.
- oral and dental care and cleaning agents according to the invention are characterized in that they contain, based on their weight, from 0.25 to 8% by weight, preferably from 0.5 to 7% by weight, particularly preferably from 0.75 to 5 wt .-%, exceptionally preferably 1 to 3 wt .-% and in particular 1, 5 to 2.5 wt .-% precipitated silica contain B ..
- Preferred oral and dental care and cleaning agents according to the invention are characterized in that the weight ratio of precipitated silica A to precipitated silica is B> 4, preferably> 4.5, more preferably> 5 and in particular> 6.
- polishing agents in the compositions according to the invention in addition to the precipitated silicas A and B. It should be noted, however, that depending on the type and amount of additional polishing agent, the abrasiveness increases or the cleaning performance is reduced, i. the success of the invention could be thwarted.
- Particularly preferred oral and dental care and cleaning agents according to the invention are therefore characterized in that they contain no further polishing agents apart from the precipitated silicas A and B.
- the oral and dental care and cleaning compositions according to the invention contain further ingredients. Preference is given here to the use of so-called humectants, which prevent dehydration in toothpastes and increase the effectiveness of the combination according to the invention. In so-called liquid tooth creams with flowable rheology these serve as a matrix and are used in higher amounts.
- oral and dental care and cleaning compositions according to the invention are preferred which - based on their weight - 0.5 to 60 wt .-%, preferably 0.75 to 55 wt .-%, particularly preferably 1 to 50 wt .-% and in particular 2 to 40 wt .-% of at least one polyhydric alcohol from the group sorbitol and / or glycerol and / or 1, 2-Propylenglycol .-% or mixtures thereof.
- sorbitol is preferred.
- mixtures of two of the three or all three may be preferred.
- a mixture of glycerol, sorbitol and 1,2-propylene glycol in a weight ratio of 1: (0.5-1) :( 0.1-0.5) has proved to be particularly advantageous.
- suitable further polyhydric alcohols are those having at least 2 OH groups, preferably mannitol, xylitol, polyethylene glycol, polypropylene glycol and mixtures thereof. Among these compounds, those having 2 to 12 OH groups, and especially those having 2, 3, 4, 5, 6 or 10 OH groups are preferred.
- the (n, n + 1) or (n, n + 2) - diols with non-terminal OH groups can also be used.
- polyhydroxy compounds having 2 OH groups are also the polyethylene and polypropylene glycols.
- polyhydric alcohols may, for. B. xylitol, propylene glycols, polyethylene glycols, especially those having average molecular weights of 200-800 are used.
- sorbitol particularly preferred is the use of sorbitol, so that agents which contain no other polyhydric alcohols other than sorbitol, are particularly preferred.
- Agents preferred according to the invention contain fluoride. This may be provided in the form of inorganic fluoride salts (sodium fluoride, stannous fluoride, sodium monofluorophosphate, etc.), and amine fluorides such as olaflur are also suitable.
- Particularly preferred oral and dental care and cleaning agents according to the invention are characterized in that they 1225 to 1575 ppm, preferably 1250 to 1550 ppm, more preferably 1275 to 1525 ppm, even more preferably 1300 to 1500 ppm, even more preferably 1325 to 1475 ppm and especially 1350 to 1450 ppm fluoride.
- fluoride When fluoride is provided in the form of sodium fluoride, 1% by weight of sodium fluoride corresponds to about 4524 ppm of fluoride, so that preferred agents of the invention are from 0.27 to 0.35% by weight, preferably from 0.28 to 0.34% by weight. more preferably 0.29 to 0.33 wt .-% and in particular 0.30 to 0.32 wt .-% sodium fluoride.
- the agents according to the invention may contain from 0.001 to 10.0% by weight of at least one calcium salt.
- Particularly preferred calcium salt (s) are used within narrower ranges, so that preferred oral and dental care and cleaning agent 0.05 to 7.5% by weight, preferably 0.1 to 5% by weight, more preferably 0.15 to 2.5% by weight and in particular 0.2 to 1.25% by weight of calcium salt (s) contain.
- Calcium hydrogen phosphate dihydrate, CaHPO ⁇ HBO is also referred to as "brushite” or as dicalcium phosphate dihydrate, depending on the reference according to the invention is preferred to use CaHP04 '2H 2 0 obtained by the CAS-Nr.: Is described 7789-77-7.
- Mouth and dental care and cleaning compositions according to the invention which contain calcium hydrogen phosphate dihydrate, CaHPO.hhO as the calcium salt have distinct abrasiveness advantages over other agents.
- the gentle cleaning of sensitive teeth is therefore compatible with the inventive combination of polylactic acid, defined silicate and calcium hydrogen phosphate dihydrate Calcium salt once again better.
- the agents of the present invention may more preferably be calcium glycerophosphate, i. a calcium salt of at least one glycerophosphoric acid.
- the glycerophosphoric acid is a dibasic acid which occurs in two isomeric forms, depending on whether the phosphoric acid group is bound to a terminal or the medial OH group of glycerol.
- the form in which the phosphoric acid moiety is bonded to a terminal OH group of the glycerol is also referred to as an alpha isomer
- the form in which the phosphoric acid moiety is bonded to the medial OH group of the glycerol is also referred to as a beta isomer.
- the alpha isomer is additionally optically active and occurs in the two enantiomeric forms sn-glycerol
- Glycerol-2-phosphate is not optically active.
- the glycerophosphoric acids are about as strong as phosphoric acid. According to the invention, the use of the alpha-isomer is preferred, regardless of which of the two enantiomers is used. If the use of enantiomerically pure compounds is desired, the calcium salt of sn-glycerol-3-phosphoric acid is preferably used.
- oral and dental care and cleaning compositions according to the invention which contain calcium salts of the glycerophosphoric acids of the formulas (Ia) and (Ib) are preferred
- Particularly preferred mouth and tooth care and cleaning agents according to the invention are characterized in that the weight ratio of the calcium salts of the formulas (Ia) to (Ib) is above 50:50, preferably above 60:40, particularly preferably above 70:30 and in particular above 80:20.
- Preferred oral and dental care and cleaning compositions according to the invention contain - based on their weight - 0.01 to 2.5 wt .-%, preferably 0.05 to 2.0 wt .-%, particularly preferably 0.1 to 1, 0 wt .-%, more preferably 0 1 1 to 0.75 wt .-% and in particular 0, 12 to 0.5 wt .-% calcium glycerophosphate.
- Very particularly preferred agents according to the invention contain 0.25 to 7.5% by weight, preferably 0.5 to 7.0% by weight, more preferably 1.0 to 6.0% by weight, more preferably 2.0 to 5.0% by weight and in particular 3.5 to 4.5% by weight of calcium hydrogen phosphate dihydrate and 0.01 to 2.5% by weight, preferably 0.05 to 2.0% by weight, particularly preferably 0.1 to 1, 0 wt .-%, more preferably 0.1 to 0.75 wt .-% and in particular 0.12 to 0.5 wt .-% calcium glycerophosphate.
- Surface-active substances can also be used in the agents according to the invention. They serve, for example, in toothpastes to support the cleaning action and, if desired, also for the development of foam in tooth brushing and for stabilizing the polishing body dispersion in the carrier and are usually used in an amount of 0.1-5 wt .-%.
- Suitable surfactants are, for. B. linear sodium alkyl sulfates having 12-18 C atoms in the alkyl group. These substances additionally have an enzyme-inhibiting effect on the bacterial metabolism of the dental plaque.
- Further suitable surfactants are alkali metal salts, preferably sodium salts of alkylpolyglycol ether sulfate having 12-16 C atoms in the linear alkyl group and 2-6 glycol ether groups in the molecule, of linear alkane (C 12- C 18) sulfonate, of sulfosuccinic acid monoalkyl (C 12-18) -ester, of sulfated fatty acid monoglycerides, sulfated fatty acid alkanolamides, sulfoacetic acid alkyl (C 12 -C 16) esters, acylsarcosines, acyl taurides and acyl isothionates each having 8-18 C atoms in the acyl group.
- zwitterionic, ampholytic and nonionic surfactants are suitable, for.
- mouth and dental care and cleansing preparations according to the invention which - based on their weight - less than 5 wt .-%, preferably less than 4 wt .-%, more preferably less than 3 wt .-% and in particular less than 2 wt .-% surfactant (s), according to the invention particularly preferred.
- preferred oral and dental care and cleaning compositions according to the invention are characterized in that they contain less than 2% by weight, preferably less than 1% by weight, more preferably less than 0.5% by weight and in particular less than 0, 1 wt .-% anionic (s) surfactant (s), preferred agents being free of anionic surfactants.
- Preferred surfactant-containing oral and dental care and cleaning compositions according to the invention contain from 0.1 to 5% by weight, preferably from 0.25 to 4% by weight, particularly preferably from 0.5 to 3.0% by weight, more preferably 0, 75 to 2.0 wt .-% and in particular 1, 0 to 1, 5 wt .-% amphoteric surfactant (s).
- Particularly preferred oral and dental care and cleaning agents according to the present invention contain from 0.1 to 5% by weight, preferably from 0.2 to 4% by weight, particularly preferably from 0.25 to 3% by weight, more preferably 0, 3 to 2 wt .-% and in particular 0.4 to 0.8 wt .-% cocoamidopropyl betaine.
- compositions according to the invention can also additionally other wound-healing and anti-inflammatory substances, eg. B. agents for gingivitis included.
- B. agents for gingivitis included Such substances may, for. B. be selected from allantoin, azulen, chamomile extracts, tocopherol, panthenol, bisabolol, sage extracts.
- Oral and dental care and cleaning agents may e.g. also contain substances that are effective against plaque and / or tartar.
- Anti-calculus substances may be, for example, chelating agents such.
- chelating agents such as ethylenediaminetetraacetic acid and its sodium salts, pyrophosphate salts such as the water-soluble dialkali or Tetraalkalimetallpyrophosphat- salts, z. Na4P20, K4P2O7, Na2K2P2Ü7, Na2H2P2Ü7 and K2H2P2O7 or polyphosphate salts, e.g. B. from water-soluble Alkalimethalltnpolyphosphaten such as sodium tripolyphosphate and Kaliumtnpolyphosphat may be selected.
- Oral and dental care and cleaning agents which are preferred according to the invention are characterized in that they additionally contain phosphate (s), preferably alkali metal phosphate (s) and in particular sodium tripolyphosphate, preferably in amounts of from 1 to 10% by weight, more preferably from 2 to 8% by weight .-% and in particular from 3 to 7 wt .-%, each based on the total agent included.
- phosphate preferably alkali metal phosphate (s) and in particular sodium tripolyphosphate, preferably in amounts of from 1 to 10% by weight, more preferably from 2 to 8% by weight .-% and in particular from 3 to 7 wt .-%, each based on the total agent included.
- a consistency regulator serve z.
- natural and / or synthetic water-soluble polymers such as alginates, carrageenan, tragacanth, starch and starch ethers, cellulose ethers such. Carboxymethylcellulose (Na salt), hydroxyethylcellulose, methylhydroxypropylcellulose, guar, acacia, agar, xanthan gum, succinoglycan gum, locust bean gum, pectins, water-soluble carboxyvinyl polymers (e.g., Carbopo D types), polyvinyl alcohol, polyvinylpyrrolidone, Polyethylene glycols, in particular those having molecular weights of 1 500-1 000 000.
- z. B phyllosilicates
- montmorillonite clays colloidal thickened silicas such.
- airgel silicas fumed silicas or finely ground precipitated silicas.
- viscosity-stabilizing additives from the group of cationic, zwitterionic or ampholytic nitrogenous surfactants, hydroxypropyl-substituted hydrocolloids or polyethylene glycol / polypropylene glycol copolymers having an average molecular weight of 1000 to 5000 or a combination of the compounds mentioned in the toothpastes.
- viscosity-stabilizing additives from the group of cationic, zwitterionic or ampholytic nitrogenous surfactants, hydroxypropyl-substituted hydrocolloids or polyethylene glycol / polypropylene glycol copolymers having an average molecular weight of 1000 to 5000 or a combination of the compounds mentioned in the toothpastes.
- the precipitated silicas A or B nor do they have any rendering properties.
- the agents according to the invention can e.g. be improved by the addition of aromatic oils and sweeteners in their organoleptic properties.
- aroma oils all the natural and synthetic flavors customary for oral and dental care products can be used. Natural flavors can be contained both in the form of natural essential oils isolated from drugs and the individual components isolated therefrom.
- Suitable flavors are e.g. Whistle oil, spearmint oil, eucalyptus oil, aniseed oil, fennel oil, caraway oil, menthyl acetate, cinnamaldehyde, anethole, vanillin, thymol and mixtures of these components. in the
- Suitable sweeteners include saccharin sodium, sodium cyclamate, sucrose, lactose, meltose, fructose.
- Other common auxiliaries and additives for toothpastes and mouthwashes or mouthwashes are
- Solvents and solubilizers e.g. lower monohydric or polyhydric alcohols or ethers, e.g. Ethanol, 1, 2-propylene glycol, diethylene glycol or butyl diglycol
- Titanium dioxide e.g. Titanium dioxide
- Buffer substances e.g. primary, secondary or tertiary alkali phosphates or citric acid / Na citrate
- wound healing or anti-inflammatory agents e.g. Allantoin, urea, azulene,
- vitamins such as e.g. Ascorbic acid, biotin, tocopherol or rutin
- Mineral salts such as e.g. Manganese, zinc or magnesium salts.
- Another object of the present invention is the use of mixtures of a) at least one precipitated silica A, which has the following properties:
- a weight average particle size (Malvern Mastersizer Model X with a 45 mm lens and an MS-5 sample presentation unit) of 8 to 13 ⁇ ; b. a BET surface area (standard nitrogen adsorption method of Brunauer, Emmett and Teller, using a single point method with a Sorpty 1750 instrument of the Carlo Erba Company, Italy) of 40 to 60 m 2 / g; c. an RDA value (determined according to Journal of Dental Research 55 (4) 563, 1976) of 50 to 120
- compositions according to the invention can be formulated as toothpastes or toothpastes.
- Another object of the present invention is the use of agents according to the invention Cleaning teeth with manually operated or electric toothbrushes.
- the compositions according to the invention have the further advantage that they are effective even in small amounts and, moreover, do not impair the mechanics of the electric brush head.
- Another object of the present invention is a method for cleaning teeth, characterized in that an inventive agent is applied to the brush head of an electric toothbrush and brushed with the electric toothbrush teeth.
- Another object of the present invention is a method for cleaning teeth, characterized by the steps
- Another object of the present invention is a polish mixture comprising - based on their weight - a) 50 to 80 wt .-% of at least one precipitated silica A, which has the following properties:
- a weight average particle size (Malvern Mastersizer Model X with a 45 mm lens and an MS-5 sample presentation unit) of 8 to 13 ⁇ ; b. a BET surface area (standard nitrogen adsorption method of Brunauer, Emmett and Teller, using a single point method with a Sorpty 1750 instrument of the Carlo Erba Company, Italy) of 40 to 60 m 2 / g; c. an RDA value (determined according to Journal of Dental Research 55 (4) 563, 1976) of 50 to 120
- a weight average particle size (Malvern Mastersizer Model X with a 45 mm lens and a MS-5 sample presentation unit) of 8 to 10 ⁇
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Abstract
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DE112015004818.9T DE112015004818A5 (de) | 2014-10-22 | 2015-09-09 | Mund- und Zahnpflege- und -reinigungsmittel mit verbesserter Poliermittelkombination |
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DE102014221450.5 | 2014-10-22 | ||
DE102014221450.5A DE102014221450A1 (de) | 2014-10-22 | 2014-10-22 | Mund- und Zahnpflege- und -reinigungsmittel mit verbesserter Poliermittelkombination |
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WO2016062450A1 true WO2016062450A1 (fr) | 2016-04-28 |
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PCT/EP2015/070557 WO2016062450A1 (fr) | 2014-10-22 | 2015-09-09 | Agents de soins et de nettoyage buccal et dentaire avec combinaison d'agents de polissage améliorée |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN117503630A (zh) * | 2023-11-27 | 2024-02-06 | 广州舒客实业有限公司 | 一种牙齿护理组合物和牙膏 |
CN117503630B (zh) * | 2023-11-27 | 2024-06-28 | 广州舒客实业有限公司 | 一种牙齿护理组合物和牙膏 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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DE102017207930A1 (de) * | 2017-05-10 | 2018-11-15 | Henkel Ag & Co. Kgaa | Zahncreme mit bambusbasierter Cellulose |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2004043419A1 (fr) * | 2002-11-13 | 2004-05-27 | J.M. Huber Corporation | Compositions abrasives pour dentifrice transparent |
WO2005065634A1 (fr) * | 2004-01-09 | 2005-07-21 | Ineos Silicas Limited | Systeme abrasif dentaire |
DE102010062611A1 (de) * | 2010-12-08 | 2012-06-14 | Henkel Ag & Co. Kgaa | Mund- und Zahnpflege- und -reinigungsmittel mit gesteigerter antibakterieller Wirkung II |
-
2014
- 2014-10-22 DE DE102014221450.5A patent/DE102014221450A1/de not_active Withdrawn
-
2015
- 2015-09-09 DE DE112015004818.9T patent/DE112015004818A5/de not_active Ceased
- 2015-09-09 WO PCT/EP2015/070557 patent/WO2016062450A1/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004043419A1 (fr) * | 2002-11-13 | 2004-05-27 | J.M. Huber Corporation | Compositions abrasives pour dentifrice transparent |
WO2005065634A1 (fr) * | 2004-01-09 | 2005-07-21 | Ineos Silicas Limited | Systeme abrasif dentaire |
DE102010062611A1 (de) * | 2010-12-08 | 2012-06-14 | Henkel Ag & Co. Kgaa | Mund- und Zahnpflege- und -reinigungsmittel mit gesteigerter antibakterieller Wirkung II |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117503630A (zh) * | 2023-11-27 | 2024-02-06 | 广州舒客实业有限公司 | 一种牙齿护理组合物和牙膏 |
CN117503630B (zh) * | 2023-11-27 | 2024-06-28 | 广州舒客实业有限公司 | 一种牙齿护理组合物和牙膏 |
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DE102014221450A1 (de) | 2016-04-28 |
DE112015004818A5 (de) | 2017-08-10 |
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