WO2016208750A1 - Mécanisme d'administration de médicament et procédé de production d'unité de pompe pour mécanisme d'administration de médicament - Google Patents

Mécanisme d'administration de médicament et procédé de production d'unité de pompe pour mécanisme d'administration de médicament Download PDF

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Publication number
WO2016208750A1
WO2016208750A1 PCT/JP2016/068910 JP2016068910W WO2016208750A1 WO 2016208750 A1 WO2016208750 A1 WO 2016208750A1 JP 2016068910 W JP2016068910 W JP 2016068910W WO 2016208750 A1 WO2016208750 A1 WO 2016208750A1
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Prior art keywords
pump
unit
characteristic data
pump unit
main body
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PCT/JP2016/068910
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English (en)
Japanese (ja)
Inventor
道 水谷
憲彦 岡本
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日東電工株式会社
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Priority to JP2017525461A priority Critical patent/JP6821270B2/ja
Publication of WO2016208750A1 publication Critical patent/WO2016208750A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body

Definitions

  • the present invention relates to a dosing mechanism for administering a liquid medicine filled in a medicine container to a patient, and a method for manufacturing a pump unit for the dosing mechanism.
  • an infusion pump device described in Patent Document 1 as a dosing mechanism for administering a liquid medicine (medical solution) filled in a medicine container to a patient.
  • This infusion pump device is configured such that a pump unit can be attached to and detached from a main body ("power supply unit" in Patent Document 1) that drives the pump.
  • a pump having a piezoelectric element like the “micro diaphragm pump” described in Patent Document 2.
  • a pump including this piezoelectric element is configured to move a diaphragm with a driving force generated by applying a voltage to the piezoelectric element to suck and discharge a fluid.
  • the piezoelectric constant of the piezoelectric element is not constant for each individual, if it is used as it is, the individual will vary in the relationship between the drive frequency input to the pump and the discharge flow rate. For this reason, in order to perform accurate drug administration to a patient, when a pump having a piezoelectric element is used in the dosing mechanism, it is necessary to suppress variations in the discharge flow rate as much as possible. Therefore, it is necessary to correct the control so that the discharge flow rate is as controlled. In other words, a trial run of a pump actually used for drug administration is performed, and the relationship between the drive frequency and the actual discharge flow rate is grasped, and then the pump control is corrected based on the relationship between the drive frequency and the discharge flow rate obtained in the trial run. There is a need to.
  • an object of the present invention is to provide a dosing mechanism that can easily correct the control when a pump including a piezoelectric element is used and the pump is replaced, and a method for manufacturing a pump unit for the dosing mechanism.
  • the present invention comprises a drug container, a main body, and a pump unit attached to the main body, a dosing mechanism for administering a liquid drug filled in the drug container to a patient
  • the pump unit comprises: A pump driven by a piezoelectric element; and a characteristic data holding unit that holds characteristic data relating to input / output of the pump in a readable manner, and the main body reads the characteristic data held in the characteristic data holding unit A reading unit; a correction unit that determines a control correction value based on the characteristic data read by the reading unit; and a pump control unit that controls the pump based on the determined control correction value.
  • This is a dosing mechanism.
  • the characteristic data is data regarding a relationship between a driving frequency input to the pump and a discharge flow rate of the pump, and the pump control unit sets the driving frequency input to the pump to the control correction value.
  • the pump can be controlled correspondingly.
  • the characteristic data holding unit may be a means for presenting information in one direction to the reading unit.
  • a method of manufacturing a pump unit for a dosing mechanism comprising: a pump driven by a piezoelectric element; and a characteristic data holding unit for holding characteristic data relating to input / output of the pump in a readable manner.
  • a plurality of actual measurement data indicating the relationship between the discharge flow rate with respect to a plurality of drive frequencies by performing a trial operation using the pump unit actually with respect to the relationship between the drive frequency input to the pump and the discharge flow rate for the pump unit.
  • a method for manufacturing a pump unit for a dosing mechanism comprising: a pump driven by a piezoelectric element; and a characteristic data holding unit for holding characteristic data relating to input / output of the pump in a readable manner.
  • FIG. 2B is a longitudinal sectional view taken along the line AA in FIG. 2A showing the main body and the pump unit with the lid portion removed according to the present embodiment. It is a rear view which shows the main body and pump unit of the state of this embodiment in the state which removed the cover part. It is a block diagram of the principal part in the medication mechanism of this embodiment.
  • the medication mechanism 1 of this embodiment includes a main body 2 and a pump unit 3 that can be attached to and detached from the main body 2. As shown in FIG. 1, the dosing mechanism 1 is attached in the middle of a dosing route F from a drug container F1 such as an infusion bag to a patient P.
  • a drug container F1 such as an infusion bag
  • the main body 2 is a part for holding the pump unit 3 and performing various detections, controls, and managements.
  • a drug container side tube F2 and a patient side tube F5 are connected to the pump unit 3 held by the main body 2.
  • the cover part which can be opened and closed is provided in the front side of the main body 2.
  • FIG. The lid portion comes into contact with the side surfaces of the suction side tube 33 and the discharge side tube 34 of the pump unit 3 when closed.
  • the upper side shown in FIGS. 2A to 2D is the drug container F1 side (suction side) when the medication mechanism 1 is used, and the lower side is the patient P side (discharge side) when used.
  • the main body 2 is provided with a pump unit arrangement recess 22 which is a recess into which the pump unit 3 can be fitted. Although a specific shape is not shown, a main body side electrical contact 2P (see FIG. 3) is provided on the bottom surface of the pump unit arrangement recess 22. When the pump unit 3 is fitted in the pump unit arrangement recess 22, electric power for driving the pump 31 can be supplied from the main body side electrical contact 2 ⁇ / b> P to the pump unit 3.
  • the pump unit arrangement recess 22 is provided with a reading unit 27 (see FIG. 3) for reading the characteristic data held in the characteristic data holding unit 38 provided in the pump unit 3.
  • the reading unit 27 uses a CCD camera when a bar code or the like is used as the characteristic data holding unit 38, and uses an electromagnetic coil when an IC chip or the like is used.
  • tube arrangement grooves 23 for arranging the suction side tube 33 and the discharge side tube 34 of the pump unit 3 are formed above and below the pump unit arrangement recess 22.
  • the main body 2 is provided with a sensor capable of detecting the liquid feeding status of the pump unit 3.
  • a pressure sensor 24 and a bubble sensor 25 are provided as this sensor.
  • the pressure sensors 24 are provided at two locations on the main body 2 on the drug container F1 side and the patient P side. However, it can be provided only at one place on the medicine container F1 side or the patient P side.
  • Each pressure sensor 24 is provided at a position corresponding to the suction side tube 33 and the discharge side tube 34 in the pump unit 3 attached to the main body 2.
  • This pressure sensor 24 utilizes a phenomenon in which the tube expands when the pressure in the tube increases, and the tube diameter expands, and when the pressure in the tube decreases, the tube contracts when the tube pressure decreases. Then, a change in pressure in each of the tubes 33 and 34 is detected by a change in the diameter of the suction side tube 33 and the discharge side tube 34.
  • each pressure sensor 24 is provided with a movable block 241 having a groove into which the tubes 33 and 34 are fitted so as to be movable between the front side and the back side. .
  • an element 242 that can output a voltage by reference to the received load is disposed in contact with the movable block 241.
  • the tubes 33 and 34 are restricted from moving to the front side by a lid (not shown) of the main body 2. For this reason, the movable block 241 moves according to the expansion / contraction of the tubes 33, 34, and the voltage output from the element 242 changes according to the load applied to the element 242. Can detect pressure changes.
  • the pump in the upstream side of the pump 31 in the pump unit 3 keeps the drug solution from flowing from the drug container F1 side. Since 31 performs suction, the suction side tube 33 contracts as the inside of the pump 31 continues to be driven to a negative pressure.
  • the pump 31 discharges in a state in which the drug solution does not easily flow to the patient P side, so that the internal pressure becomes positive and the discharge side tube 34 expands by continuing to drive the pump 31. To do. For this reason, the occurrence of the blockage can be grasped by the detection of the pressure sensor 24.
  • a bypass pipe 35 and a bypass opening / closing valve 36 are provided in the pump unit 3 as a relief flow path for releasing excess chemical liquid generated at the time of closure so that no inconvenience occurs after the closure is released. May be.
  • the main body 2 includes, for example, a control unit 261 that performs pump control of the pump unit 3 and processing and storage of detection results of each sensor, an internal power supply unit 262 in which a battery is disposed, an external power input jack 263, a medicine container A flow rate jack 264 for inputting a detection value of a flow rate sensor for detecting a drip amount and the like attached to a drip tube (not shown) located on the patient P side from F1, communication for outputting medication history data and sensor detection results, etc.
  • a jack 265 may be provided.
  • a display portion 266 having a liquid crystal display or the like that can display various information, and an input portion 267 (see FIG. 3) having operation buttons and the like can be provided.
  • wearing the main body 2 to the patient's P body, the part for attaching to the drip stand etc. which are used in a medical institution can also be provided.
  • the control unit 261 controls the pump 31 based on the correction unit 2611 that determines the control correction value based on the characteristic data of the pump 31 in the pump unit 3 read by the reading unit 27 and the determined control correction value.
  • the pump unit 3 includes a pump 31, a free flow prevention valve 32, a suction side tube (suction side piping) 33, a discharge side tube (discharge side piping) 34, and the like.
  • the pump 31 and the free flow prevention valve 32 are housed in a case 37 (see FIGS. 2A and 2C) and integrated. For this reason, the pump unit 3 can be easily attached to and detached from the main body 2.
  • connectors 331 and 341 that can be connected to the drug containers F1 or the tubes F2 and F5 extending from the patient P are provided.
  • a pump unit side electrical contact 3P (see FIG. 3) that can be connected to the main body side electrical contact 2P is formed on the back surface of the case 37. Therefore, the pump 31 is made by making the back surface of the case 37 coincide with the bottom surface of the pump unit arrangement recess 22 of the main body 2 and electrically connecting the main body side electric contact 2P and the pump unit side electric contact 3P (see FIG. 3). It can be made into a state which can be driven by energizing.
  • the pump unit 3 includes a characteristic data holding unit 38 that holds the characteristic data related to the input / output of the pump 31 in a readable manner.
  • the characteristic data is different for each individual pump 31.
  • the characteristic data is data about the relationship between the drive frequency input to the pump 31 and the discharge flow rate that is the output of the pump 31.
  • the characteristic data varies among the individual pumps 31 because the piezoelectric constants of the piezoelectric elements incorporated in the pump 31 are not constant for each individual, so that the operation (vibration) of the diaphragm by the piezoelectric elements is uniform for all the individual elements. It is thought that one factor is not. In addition to the above factors, other factors may have a combined effect.
  • This characteristic data is obtained for a plurality of (six points in this embodiment) by actually using the pump unit 3 for a trial operation of the relationship between the driving frequency input to the pump 31 and the discharge flow rate for each pump unit 3.
  • a plurality of actual measurement data indicating the relationship of the discharge flow rate with respect to the drive frequency is obtained and determined based on the actual measurement data.
  • the characteristic data holding unit 38 a means for presenting information in one direction to the reading unit 27 of the main body 2 can be used.
  • a two-dimensional code such as a barcode or a QR code (registered trademark in Japan) is used. Examples include IC chips that are not written (overwritten), but are not limited to these, and various means can be used.
  • the characteristic data holding unit 38 is formed in the pump unit 3 by being attached to the surface of the case 37 or being embedded in the pump unit 3, for example. Since the means for presenting information in one direction is used as the characteristic data holding unit 38, the reading unit 27 can be configured to only read the characteristic data. Therefore, the configuration of the characteristic data holding unit 38 and the reading unit 27 is simplified. Can be
  • the pump 31 can suck a liquid medicine (medical solution) from the medicine container F1 and discharge it to the patient P.
  • a diaphragm type pump is used.
  • Employing a diaphragm pump as the pump 31 eliminates the need for a motor, so that the pump can be made smaller than a pump that requires a motor. For this reason, since the pump unit 3 can also be reduced in size, the dosing mechanism 1 can be reduced in weight. Therefore, the burden when the patient P carries the medication mechanism 1 is reduced, and the merit is particularly great for the patient P who needs to always administer the drug solution.
  • the diaphragm pump can control the discharge amount of the chemical solution with high accuracy.
  • the pump 31 of the present embodiment is a pump in which a diaphragm is driven by a piezoelectric element (piezo element), specifically, a pump using MEMS technology related to an integrated device.
  • piezoelectric element piezo element
  • MEMS technology related to an integrated device.
  • Japanese Unexamined Patent Publication No. 2013-117211 are used.
  • the free flow prevention valve 32 is provided to prevent an unintended flow passing through the pump 31 from being generated due to the pressure of the chemical liquid generated by gravity when the pump 31 is not driven.
  • the suction side tube 33 is a tube extending from the pump 31 to the medicine container F1 side.
  • the discharge side tube 34 is a tube extending from the pump 31 to the patient P side.
  • These tubes 33 and 34 are made of a soft resin such as silicon rubber, for example. Since changes in the diameters of the tubes 33 and 34 are detected by the pressure sensor 24 of the main body 2, at least a portion arranged in the pressure sensor 24 in advance with respect to material (mixing of resin, density, etc.), tube thickness, and tube diameter. It must be formed within a predetermined error range.
  • a hard pipe can also be used for the pump unit 3 without using a soft tube.
  • the connectors 331 and 341 are provided at the tips of the tubes 33 and 34, respectively.
  • the connectors 331 and 341 are general-purpose products made of hard resin. For example, by screwing, as shown in FIG. 1, the medicine container side tube F2 and the patient side tube F5 (each can be connected to the connectors 331 and 341 of the pump unit 3).
  • the connectors F3 and F4 having the shapes of “male” and “female”.
  • the connectors 331 and 341 allow the pump unit 3 and the drug container side tube F2 to be separated, and the pump unit 3 and the patient side tube F5 can be separated, so that the distance between the drug container F1 and the patient P with respect to the dosing mechanism 1 can be freely set. Can be set. Therefore, when the patient P carries the medication mechanism 1, the tubes F2 and F5 are unlikely to get in the way.
  • the pump unit 3 of this embodiment can be disposable. For this reason, the medication mechanism 1 can be used hygienically and safely. Depending on the type and usage of the medicine, the pump unit 3 is usually replaced in about 3 days, or in about 30 days if it is long. By making the pump unit 3 disposable, it is not necessary to perform a discharge accuracy test performed by a clinical engineer (ME) in a medical institution. Therefore, management of the medication mechanism 1 in a medical institution becomes easy, and in the future, there is a possibility that the medication mechanism 1 can be managed by a nurse or the like on a ward basis without the need of a clinical engineer. In some cases, the pump unit 3 is not disposable and can be reused.
  • ME clinical engineer
  • the method for manufacturing the pump unit 3 includes at least the following three steps.
  • One shows the relationship between the discharge flow rate with respect to a plurality of drive frequencies by performing a trial operation using the pump unit 3 in practice on the relationship between the drive frequency input to the pump 31 and the discharge flow rate that is the output of the pump 31.
  • This is a step of obtaining a plurality of actually measured data.
  • the other is a step of determining characteristic data based on the plurality of actually measured data obtained in the trial operation.
  • the other is a step of holding the predetermined characteristic data in the characteristic data holding unit 38.
  • the present embodiment obtains actual measurement data of the discharge flow rate for six driving frequencies (n1, n2,..., N6) of different sizes. For this reason, the characteristic data of this embodiment includes seven discharge flow rates (0 to n1 (less than), n1 (more than) to n2 (less than),..., N6 (or more) to) divided by the six points. Determined.
  • the property data is stored in the property data holding unit 38.
  • an object formed by printing a barcode, a two-dimensional code or the like is used as the property data holding unit 38, the property data is converted into a code on a sheet-like body. After the printed product is printed, it is affixed to the surface of the case 37, or the code is directly printed on the surface of the case 37. Further, in the case where an object formed by electromagnetic processing such as an IC chip is used as the characteristic data holding unit 38, the characteristic data converted into electromagnetic information is written and then attached to the surface of the case 37. Is made by However, the method is not limited to these exemplified methods, and the characteristic data can be held in the characteristic data holding unit 38 by various methods.
  • the tube F2 extending from the medicine container F1 and the tube F5 extending from the patient P side are connected to the pump unit 3.
  • the pump unit 3 in a state where the tube F2 and the tube F5 are connected to each other is mounted on the main body 2 to obtain the state shown in FIG. If necessary, a drip tube or a flow sensor is attached.
  • air bubbles in the administration route F are removed.
  • the needle F6 is inserted into the patient P.
  • driving of the pump 31 is started. Thereby, a chemical
  • a medical worker such as a nurse sets the pump unit 3 on the main body 2 (step S1). Thereafter, when a medical worker turns on the power of the main body 2, the control unit 261 reads the characteristic data held in the characteristic data holding unit 38 via the reading unit 27 (step S2). Next, the discharge flow rate is set by an input to the input unit 267 by the medical staff (step S3).
  • step S3 when the discharge flow rate set in step S3 exceeds the reference value n1 and is equal to or smaller than the reference value n2 larger than the reference value n1 (steps S4 and S8), the correction unit 2611 applies the coefficients A and B.
  • the determination of the driving frequency is the same as described above.
  • the characteristic data is set for seven sections (the discharge flow rate is set to 0 to n1 (less than), n1 (more) to n2 (less than),..., N6 (more than)), so that the driving frequency is set. This is determined in seven stages as the discharge flow rate set by the medical staff increases.
  • the “determined drive frequency” is a drive in which the drive frequency input to the pump 31 is increased or decreased corresponding to the control correction value so that a desired discharge flow rate is discharged when the pump 31 is actually operated. Is the frequency. Therefore, the pump control unit 2612 controls the pump 31 by increasing or decreasing the drive frequency input to the pump 31 corresponding to the control correction value. Thus, even if the pump unit 3 is replaced with another individual, a desired discharge flow rate can be easily obtained by inputting the increased or decreased drive frequency to the pump 31, so that the characteristic data of the pump unit 3 after replacement can be obtained. Accordingly, the drug solution can be administered to the patient P with a discharge flow rate that is slightly different from the discharge flow rate set by the medical staff.
  • FIG. 5 is a flow diagram obtained by modifying FIG. In the flow of FIG. 5, the blood pressure correction is different from the flow of FIG.
  • a and B are set in the correction unit 2611 (steps S5 and S9), it is determined whether or not blood pressure correction is performed (step S10).
  • the necessity of blood pressure correction can be set in advance by, for example, an input to the input unit 267 by a medical worker. Further, when the medication mechanism 1 is configured to measure the blood pressure of the patient P, the necessity of blood pressure correction can be automatically set with a predetermined blood pressure as a boundary.
  • step S10 If NO in step S10 ("None" in the figure), the flow is exactly the same as in the flow of FIG. On the other hand, in the case of “Yes” (“Yes” in the figure), the drive frequency is fixed (Step S6) after being corrected by the correction coefficient preset in the correction unit 2611 (Step S11), and the control is corrected. Such setting is completed (step S7).
  • the correction coefficient is corrected so that the drive frequency becomes higher when the discharge flow rate setting is the same as the flow in FIG. Thereby, it can suppress that the dosage of the chemical
  • the pump unit 3 holds the characteristic data holding unit 38 so that the reading unit 27 can read it. For this reason, even if the pump unit 3 is replaced, the control correction value is easily determined, and accurate control corresponding to different characteristics for each individual pump 31 can be quickly performed.
  • the actually measured data of the discharge flow rate with respect to the driving frequency of 6 points is obtained.
  • the present invention is not limited to this. You can also.
  • the embodiment includes a medicine container F1, a main body 2, and a pump unit 3 attached to the main body 2, and a dosing mechanism 1 for administering a liquid medicine filled in the medicine container F1 to a patient P.
  • the pump unit 3 includes a pump 31 driven by a piezoelectric element, and a characteristic data holding unit 38 that holds characteristic data relating to input / output of the pump 31 in a readable manner.
  • a reading unit 27 that reads the characteristic data held in the characteristic data holding unit 38, a correction unit 2611 that determines a control correction value based on the characteristic data read by the reading unit 27, and the determined control correction And a pump control unit 2612 that controls the pump 31 based on a value.
  • the pump unit 3 holds the characteristic data holding unit 38 so that the reading unit 27 can read it. For this reason, even if the pump unit 3 is replaced, the control correction value can be easily determined, and accurate control according to different characteristics for each individual pump unit 3 can be quickly performed.
  • the characteristic data is data about the relationship between the drive frequency input to the pump 31 and the discharge flow rate of the pump 31, and the pump control unit 2612 sets the drive frequency input to the pump 31 to the drive frequency.
  • the pump 31 can be controlled by increasing or decreasing in accordance with the control correction value.
  • the target discharge flow rate can be easily obtained by increasing or decreasing the drive frequency.
  • the characteristic data holding unit 38 may be a means for presenting information in one direction to the reading unit 27.
  • the reading unit 27 can be configured to only read the characteristic data, the configuration of the characteristic data holding unit 38 and the reading unit 27 can be simplified.
  • the embodiment also includes a pump unit 3 for a dosing mechanism, which includes a pump 31 driven by a piezoelectric element, and a characteristic data holding unit 38 that holds characteristic data relating to input / output of the pump 31 in a readable manner.
  • a pump unit 3 for a dosing mechanism which includes a pump 31 driven by a piezoelectric element, and a characteristic data holding unit 38 that holds characteristic data relating to input / output of the pump 31 in a readable manner.
  • the characteristic data is determined by a trial operation that actually uses the pump unit 3, the characteristic data can be accurately determined.
  • the control correction value is easily determined even when the pump unit 3 is replaced, and accurate control according to different characteristics for each individual pump unit 3 can be quickly performed. Therefore, when the pump 31 is replaced, the control can be easily corrected.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne un mécanisme d'administration de médicament qui permet d'administrer un médicament liquide emballé dans un récipient de médicament (F1) à un patient. Le mécanisme d'administration de médicament est pourvu du récipient de médicament (F1), d'un corps principal (2), et d'une unité de pompe (3) fixée au corps principal (2). L'unité de pompe (3) est dotée d'une pompe qui est entraînée par un élément piézoélectrique et d'une unité de conservation de données caractéristiques destinée à conserver de façon lisible des données caractéristiques (38) relatives à l'entrée/la sortie de la pompe. Le corps principal (2) est pourvu des éléments suivants : une unité de lecture (27) qui lit les données caractéristiques conservées par l'unité de conservation des données caractéristiques (38) ; une unité de correction (2611) qui détermine une valeur de correction de commande sur la base des données caractéristiques lues par l'unité de lecture (27) ; et une unité de commande de pompe (2612) qui commande la pompe sur la base de la valeur de correction de commande déterminée.
PCT/JP2016/068910 2015-06-26 2016-06-24 Mécanisme d'administration de médicament et procédé de production d'unité de pompe pour mécanisme d'administration de médicament WO2016208750A1 (fr)

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CN113058500A (zh) * 2020-01-02 2021-07-02 中国石油天然气集团有限公司 钻井液制备设备及钻井液制备方法

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CN106730130A (zh) * 2017-01-17 2017-05-31 深圳市好克医疗仪器股份有限公司 一种带有压力自动调零和验证的输液泵
CN113058500A (zh) * 2020-01-02 2021-07-02 中国石油天然气集团有限公司 钻井液制备设备及钻井液制备方法
CN113058500B (zh) * 2020-01-02 2024-05-31 中国石油天然气集团有限公司 钻井液制备设备及钻井液制备方法

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