WO2016197276A1 - 一种含有牛蒡子苷元的中药组合物及其制备方法 - Google Patents

一种含有牛蒡子苷元的中药组合物及其制备方法 Download PDF

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WO2016197276A1
WO2016197276A1 PCT/CN2015/000421 CN2015000421W WO2016197276A1 WO 2016197276 A1 WO2016197276 A1 WO 2016197276A1 CN 2015000421 W CN2015000421 W CN 2015000421W WO 2016197276 A1 WO2016197276 A1 WO 2016197276A1
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chinese medicine
traditional chinese
medicine composition
arctigenin
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PCT/CN2015/000421
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杨磊
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杨磊
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates

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  • the invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition containing arctigenin and a preparation method thereof.
  • Hair loss is divided into seborrheic alopecia, androgenetic alopecia, mental alopecia, endocrine dysfunctional alopecia, hemorrhagic alopecia, chemical alopecia, nutritional metabolic alopecia, hair loss.
  • Excessive mental stress is a common cause of hair loss.
  • Mental stress, depression, fear or severe insomnia can cause neurological disorders, capillaries continue to contract, hair follicles do not have sufficient blood supply, and the scalp is at the uppermost end of the body, so the hair is most likely to fall off.
  • the object of the present invention is to provide a traditional Chinese medicine composition containing arctigenin which is capable of preventing hair loss and capable of hair growth, and a preparation method thereof, to solve the problems raised in the above background art.
  • the present invention provides the following technical solutions:
  • a traditional Chinese medicine composition containing arctigenin consisting of the following components: 50-60 parts of arctigenin, 15-20 parts of Ophiopogon japonicus, 10-15 parts of Atractylodes, 5-10 parts of Chuanxiong, and 5-10 pieces of borneol 5 parts, cinnamon 5-10 parts, hazelnut 5-10 parts, French mid-summer 1-5 parts, eucalyptus 1-5 parts, psoralen 1-5 parts, hawthorn 5-10 parts, forsythia 5-10 parts 5-10 copies of honeysuckle.
  • the traditional Chinese medicine composition containing arctigenin comprises the following components: 53-57 parts of arctigenin, 16-18 parts of Ophiopogon, 12-14 parts of Atractylodes, and Chuanxiong 7-9 parts, 7-9 parts of borneol, 7-9 parts of cinnamon, 7-9 parts of wolfberry, 2-3 parts of Pinellia ternata, 2-3 parts of Polygonatum, 2-3 parts of psoralen, and 7-inch hawthorn 9 parts, 7-9 copies of forsythia, 7-9 parts of honeysuckle.
  • the traditional Chinese medicine composition containing arctigenin comprises the following components: 55 parts of arctigenin, 17 parts of Ophiopogon japonicus, 13 parts of Atractylodes, 8 parts of Chuanxiong, 8 parts of borneol, and cinnamon. 8 parts, 8 parts of medlar, 2 parts of French Pinellia, 2 parts of Polygonatum, 2 parts of psoralen, 8 parts of Hawthorn, 8 pieces of Forsythia, and 8 parts of honeysuckle.
  • the preparation method of the traditional Chinese medicine composition containing arctigenin uses supercritical extraction method, and the specific steps include:
  • arctiin has anti-pancreatic cancer activity, and one of its action mechanisms is to induce apoptosis.
  • This product can cause vasodilation, blood pressure drop; chills in cold-blooded and warm-blooded animals, respiratory failure in large doses, and redness of skin in mice, diarrhea, inhibition of isolated rabbit intestines and uterus. It is paralyzed by motor nerves and bones and can cause mild tail-tailing reactions in mice.
  • Cangshu dampness and spleen, phlegm and cold, eyesight Used for wet resistance in the coke, abdominal fullness, diarrhea, edema, athlete's foot sputum, rheumatism, cold, cold, night blindness, eyes fainting.
  • Ligustrazine in Chuanxiong can expand coronary arteries, increase coronary blood flow, improve myocardial oxygen supply, and reduce myocardial oxygen consumption; ligustrazine can dilate cerebral vessels, reduce vascular resistance, and significantly increase brain and limb blood flow.
  • Improve microcirculation reduce platelet surface activity, inhibit platelet aggregation, prevent thrombus formation; contain low dose of ferulic acid neutral ingredient, high dose inhibit uterine smooth muscle; water decoction has sedative to animal central nervous system Function, and has obvious and lasting antihypertensive effect; can accelerate the absorption of local hematoma in the fracture, promote the formation of osteophytes; have anti-vitamin E deficiency; can inhibit a variety of bacilli; have anti-histamine and choleretic effects.
  • the borneol is fragrant and fragrant, with the effect of refreshing, clearing away heat and dispersing poison, clearing the eye and retreating. It treats fever, high fever, fainting, stroke, epilepsy, soreness, clearing, throat, deafness, sore gums, sores ⁇ , red eyes and swelling, aponeurosis
  • Cinnamon has the effect of supplementing the fire and helping the yang, igniting the fire, returning the cold, relieving the pain, and warming the meridians.
  • Cinnamon has the effect of supplementing the fire and helping the yang, igniting the fire, returning the cold, relieving the pain, and warming the meridians.
  • Hazelnut fruit contains alfalfa polysaccharide, which contains betaine, atropine, and scorpionamine. It also contains zeaxanthin, physalein, cryptoxanthin, and scopoletin. ), carotene, riboflavin, niacin, vitamins B1, B2, and C. Seeds contain amino acids: aspartic acid, valine, alanine, leucine, and the like. Nourish the liver and kidney, benefit the eyesight. For liver and kidney yin deficiency, this product is Ganping quality, flattening liver and kidney, has nourishing and strong effect, all liver and kidney yin deficiency can be applied.
  • the law is dry and phlegm in the summer. It is used for dry throat, phlegm and cough, sputum, dizziness, dizziness, and headache.
  • Yuzhu Yuzhu has the functions of nourishing yin, moistening dryness, clearing heat, producing fluid and relieving cough. Used as a nourishing drug, attending fever, yin, heat, dry cough, heart disease, diabetes, tuberculosis and other symptoms.
  • Hawthorn digestion and stomach qi and phlegm, turbidity and lipid-lowering. It is used for meat stagnation, stomach cramps, diarrhea, abdominal pain, blood stasis, postpartum sputum, tingling, chest pain, suffocation, hyperlipidemia.
  • Jiaoshan ⁇ digestion on food is enhanced. It is used for stagnant meat and is not good for diarrhea.
  • Honeysuckle is sweet and fragrant, sweet and cold, without damaging the stomach. Honeysuckle can not only dispel the wind and heat, but also clear the blood and poison, used for various heat and sexual diseases, such as body heat, rash, hair spots, heat sores, sore throat and so on, all have significant effects.
  • the invention has the beneficial effects that the invention is used for treating hair loss, has good therapeutic effect, and can promote hair growth, and the total effective rate is over 95%.
  • the raw materials are convenient to take, the price is low, the preparation process is simple, the cost is low, and the industrial production is easy.
  • a traditional Chinese medicine composition containing arctigenin is composed of the following components: 50 parts of arctigenin, 15 parts of Ophiopogon, 10 parts of Atractylodes, 5 parts of Chuanxiong, 5 parts of borneol, and 5 parts of cinnamon. 5 parts, 5 dumplings, 1 part of French Pinellia, 1 part of Polygonatum, 1 part of psoralen, 5 parts of hawthorn, 5 parts of forsythia, 5 parts of honeysuckle.
  • the preparation method of the traditional Chinese medicine composition containing arctigenin uses supercritical extraction method, and the specific steps include:
  • a traditional Chinese medicine composition containing arctigenin is composed of the following components: 60 parts of arctigenin, 20 parts of Ophiopogon, 15 parts of Atractylodes, 10 parts of Chuanxiong, 10 parts of borneol, and 10 pieces of cinnamon. 10 parts, 10 medlar, 5 parts of Pinellia, 5 parts of Polygonatum, 5 parts of psoralen, 10 parts of Hawthorn, 10 parts of Forsythia, and 10 parts of honeysuckle.
  • the preparation method of the traditional Chinese medicine composition containing arctigenin uses supercritical extraction method, and the specific steps include:
  • a traditional Chinese medicine composition containing arctigenin is composed of the following components: 53 parts of arctigenin, 16 parts of Ophiopogon japonicus, 12 parts of Atractylodes, 7 parts of Chuanxiong, 7 parts of borneol, and 7 pieces of cinnamon. 7 parts, 7 medlar, 2 parts of Pinellia, 2 parts of Polygonatum, 2 parts of psoralen, 7 parts of Hawthorn, 7 pieces of Forsythia, and 7 parts of honeysuckle.
  • the preparation method of the traditional Chinese medicine composition containing arctigenin uses supercritical extraction method, and the specific steps include:
  • a traditional Chinese medicine composition containing arctigenin is composed of the following components: 57 parts of arctigenin, 18 parts of Ophiopogon japonicus, 14 parts of Atractylodes, 9 parts of Chuanxiong, 9 parts of borneol, and 9 pieces of cinnamon. 9 parts, 9 medlar, 3 parts of Pinellia, 3 parts of Polygonatum, 3 parts of psoralen, 9 parts of Hawthorn, 9 pieces of Forsythia, 9 parts of honeysuckle.
  • the preparation method of the traditional Chinese medicine composition containing arctigenin uses supercritical extraction method, and the specific steps include:
  • a traditional Chinese medicine composition containing arctigenin is composed of the following components: 55 parts of arctigenin, 17 parts of Ophiopogon japonicus, 13 parts of Atractylodes, 8 parts of Chuanxiong, 8 parts of borneol, and 8 pieces of cinnamon. 8 parts, scorpion 8 parts, French pinellia 2 2 parts, 2 pieces of Polygonatum, 2 parts of psoralen, 8 parts of Hawthorn, 8 pieces of Forsythia, 8 pieces of honeysuckle.
  • the preparation method of the traditional Chinese medicine composition containing arctigenin uses supercritical extraction method, and the specific steps include:
  • the traditional Chinese medicine composition prepared in the above examples was applied to the affected part of the patient with symptoms of alopecia, twice a day, one course of treatment was 8 days, and the number of patients per implementation was 20. After 2 courses of treatment, the patient's hair loss after observation, the removal of the image is completely stopped as an effective case, the de-discovery image stops and there is a new occurrence, for the special effect case, calculate the number of effective cases and special effects cases, as shown in Table 1. Shown.

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Abstract

一种含有牛蒡子苷元的中药组合物及其制备方法，由以下成分组成：牛蒡子苷元50-60份、麦冬15-20份、苍术10-15份、川穹5-10份、冰片5-10份、肉桂5-10份、枸杞子5-10份、法半夏1-5份、玉竹1-5份、补骨脂1-5份、山楂5-10份、连翘5-10份、金银花5-10份，采用超临界萃取法制得，用于治疗脱发，治疗效果佳，并能促进生发，总有效率达到95％以上，各原料取材方便，价格低廉，制备过程操作简便，成本低，易于工业化生产。

Description

一种含有牛蒡子苷元的中药组合物及其制备方法 技术领域
本发明涉及中药领域，具体是一种含有牛蒡子苷元的中药组合物及其制备方法。
背景技术
脱发分为脂溢性脱发、雄激素性脱发、精神性脱发、内分泌失调性脱发、失血性脱发、化学性脱发、营养代谢障碍性脱发、头癣性脱发。精神压力过度是导致脱发常见病因。精神紧张、忧郁、恐惧或严重失眠等均能致使神经功能紊乱，毛细血管持续处于收缩状态，毛囊得不到充足的血液供应，而头皮位于人体的最上端，因而头发最易脱落。贫血、营养不良、急性高热、感染性疾病或长期肝病，如果干扰了发根部毛母细胞的功能，则会影响头发的生长与色泽，甚至使毛母细胞正常分裂被抑制，而使毛发处于休止期，出现头发脱落。现有技术中能防止脱发的中药配方较多，但是在防治脱发的同时还能够生发的中药较少。
发明内容
本发明的目的在于提供一种防治脱发并能生发的含有牛蒡子苷元的中药组合物及其制备方法，以解决上述背景技术中提出的问题。
为实现上述目的，本发明提供如下技术方案：
一种含有牛蒡子苷元的中药组合物，由以下成分组成：牛蒡子苷元50-60份、麦冬15-20份、苍术10-15份、川穹5-10份、冰片5-10份、肉桂5-10份、枸杞子5-10份、法半夏1-5份、玉竹1-5份、补骨脂1-5份、山楂5-10份、连翘5-10份、金银花5-10份。
作为本发明进-步的方案：所述含有牛蒡子苷元的中药组合物，由以下成分组成：牛蒡子苷元53-57份、麦冬16-18份、苍术12-14份、川穹7-9份、冰片7-9份、肉桂7-9份、枸杞子7-9份、法半夏2-3份、玉竹2-3份、补骨脂2-3份、山楂7-9份、连翘7-9份、金银花7-9份。
作为本发明进一步的方案：所述含有牛蒡子苷元的中药组合物，由以下成分组成：牛蒡子苷元55份、麦冬17份、苍术13份、川穹8份、冰片8份、肉桂8份、枸杞子8份、法半夏2份、玉竹2份、补骨脂2份、山楂8份、连翘8份、金银花8份。
所述含有牛蒡子苷元的中药组合物的制备方法，采用超临界萃取法，具体步骤包括：
1)将麦冬、苍术、川穹、冰片、肉桂、枸杞子、法半夏、玉竹、补骨脂、山楂、连翘、金银花的混合物粉碎，过100-140目筛，置于萃取釜中进行萃取，萃取温度为80-90□，萃取压力为5-10MPa，萃取时间为5-6h，收集挥发油，即得混合物的提取物；
2)向提取物中放入牛蒡子苷元，混合均匀后浓缩成浸膏，将浸膏放入真空干燥箱中干燥，得到干膏，干燥温度为50-55℃，干燥时间为24-36h；
3)将干膏粉碎，加入药学上可接受的辅料制备成药学上常用的中药组合物。
作为本发明进一步的方案：用于治疗脱发。
本发明中各原料的作用机理：牛蒡子苷具有抗胰腺癌活性，其作用机理之一是诱导细胞凋亡。本品能引起血管扩张，血压下降；使冷血及温血动物产生惊厥，大剂量引起呼吸衰竭，并使小鼠皮肤发红，腹泻，对离体兔肠及子宫则抑制之。对运动神经及骨胳呈麻痹作用，并能引起小鼠的轻度举尾反应。
麦冬养阴生津，润肺清心。用于肺燥干咳，阴虚痨嗽，喉痹咽痛，津伤口渴，内热消渴，心烦失眠，肠燥便秘。
苍术燥湿健脾，祛风散寒，明目。用于湿阻中焦，脘腹胀满，泄泻，水肿，脚气痿蹙，风湿痹痛，风寒感冒，夜盲，眼目昏涩。
川穹中的川芎嗪能扩张冠状动脉，增加冠状动脉血流量，改善心肌的血氧供应，并降低心肌的耗氧量；川芎嗪可扩张脑血管，降低血管阻力，显著增加脑及肢体血流量，改善微循环；能降低血小板表面活性，抑制血小板凝集，预防血栓的形成，；所含阿魏酸的中性成分小剂量促进，大剂量抑制子宫平滑肌；水煎剂对动物中枢神经系统有镇静作用，并有明显而持久的降压作用；可加速骨折局部血肿的吸收，促进骨痂形成；有抗维生素E缺乏作用；能抑制多种杆菌；有抗组织胺和利胆作用。
冰片清香宣散，具有开窍醒神，清热散毒，明目退翳的功效，主治热病高热神昏，中风痰厥惊痫，暑湿蒙蔽清窍，喉痹耳聋，口疮齿肿，疮痈疳痔，目赤肿痛，翳膜遮睛
肉桂有补火助阳，引火归元，散寒止痛，温通经脉的功效。用于阳痿宫冷，腰膝冷痛，肾虚作喘，虚阳上浮，眩晕目赤，心腹冷痛，虚寒吐泻，寒疝腹痛，痛经经闭。
枸杞子果实含枸杞多糖，又含甜菜碱(betaine)、阿托品、天仙子胺；另含玉蜀黍黄素(zeaxanthin)、酸浆红素(physalein)、隐黄质(cryptoxanthin)、东莨菪素(scopoletin)、胡萝卜素、核黄素、烟酸、维生素B1、B2及C.种子含氨基酸：天冬氨酸、脯氨酸、丙氨酸、亮氨酸等。滋补肝肾，益精明目。用于肝肾阴虚证本品甘平质润，平补肝肾，有滋补强壮作用，凡肝肾阴虚诸证均可应用。
法半夏燥湿化痰。用于咽喉干燥，痰多咳喘，痰饮眩悸，风痰眩晕，痰厥头痛。
玉竹玉竹具养阴、润燥、清热、生津、止咳等功效。用作滋补药品，主治热病伤阴、虚热燥咳、心脏病、糖尿病、结核病等症。
补骨脂补肾壮阳，固精缩尿，肾虚腰痛，小便频数，小儿遗尿，肾漏，温脾止泻，纳气平喘。用于治疗肾虚阳痿，腰膝酸软冷痛，肾虚遗精，遗尿，尿频等。用于治疗脾肾阳虚引起的五更泄泻。用于治疗肾不纳气之虚寒喘咳。
山楂消食健胃，行气散瘀，化浊降脂。用于肉食积滞，胃脘胀满，泻痢腹痛，瘀血经闭，产后瘀阻，心腹刺痛，胸痹心痛，疝气疼痛，高脂血症。焦山楂消食导滞作用增强。用于肉食积滞，泻痢不爽。
连翘清热，解毒，散结，消肿。治温热，丹毒，斑疹，痈疡肿毒，瘰疬，小便淋闭。
金银花性甘寒气芳香，甘寒清热而不伤胃，芳香透达又可祛邪。金银花既能宣散风热，还善清解血毒，用于各种热性病，如身热、发疹、发斑、热毒疮痈、咽喉肿痛等症，均效果显著。
与现有技术相比，本发明的有益效果是：本发明用于治疗脱发，治疗效果佳，并能促进生发，总有效率达到95％以上。本发明中各原料取材方便，价格低廉，制备过程操作简便，成本低，易于工业化生产。
具体实施方式
下面将结合本发明实施例，对本发明实施例中的技术方案进行清楚、完整地描述，显 然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1
本发明实施例中，一种含有牛蒡子苷元的中药组合物，由以下成分组成：牛蒡子苷元50份、麦冬15份、苍术10份、川穹5份、冰片5份、肉桂5份、枸杞子5份、法半夏1份、玉竹1份、补骨脂1份、山楂5份、连翘5份、金银花5份。
所述含有牛蒡子苷元的中药组合物的制备方法，采用超临界萃取法，具体步骤包括：
1)将麦冬、苍术、川穹、冰片、肉桂、枸杞子、法半夏、玉竹、补骨脂、山楂、连翘、金银花的混合物粉碎，过100-140目筛，置于萃取釜中进行萃取，萃取温度为80□，萃取压力为10MPa，萃取时间为6h，收集挥发油，即得混合物的提取物；
2)向提取物中放入牛蒡子苷元，混合均匀后浓缩成浸膏，将浸膏放入真空干燥箱中干燥，得到干膏，干燥温度为50℃，干燥时间为36h；
3)将干膏粉碎，加入药学上可接受的辅料制备成药学上常用的中药组合物。
实施例2
本发明实施例中，一种含有牛蒡子苷元的中药组合物，由以下成分组成：牛蒡子苷元60份、麦冬20份、苍术15份、川穹10份、冰片10份、肉桂10份、枸杞子10份、法半夏5份、玉竹5份、补骨脂5份、山楂10份、连翘10份、金银花10份。
所述含有牛蒡子苷元的中药组合物的制备方法，采用超临界萃取法，具体步骤包括：
1)将麦冬、苍术、川穹、冰片、肉桂、枸杞子、法半夏、玉竹、补骨脂、山楂、连翘、金银花的混合物粉碎，过100-140目筛，置于萃取釜中进行萃取，萃取温度为90□，萃取压力为5MPa，萃取时间为5h，收集挥发油，即得混合物的提取物；
2)向提取物中放入牛蒡子苷元，混合均匀后浓缩成浸膏，将浸膏放入真空干燥箱中干燥，得到干膏，干燥温度为55℃，干燥时间为24h；
3)将干膏粉碎，加入药学上可接受的辅料制备成药学上常用的中药组合物。
实施例3
本发明实施例中，一种含有牛蒡子苷元的中药组合物，由以下成分组成：牛蒡子苷元53份、麦冬16份、苍术12份、川穹7份、冰片7份、肉桂7份、枸杞子7份、法半夏2份、玉竹2份、补骨脂2份、山楂7份、连翘7份、金银花7份。
所述含有牛蒡子苷元的中药组合物的制备方法，采用超临界萃取法，具体步骤包括：
1)将麦冬、苍术、川穹、冰片、肉桂、枸杞子、法半夏、玉竹、补骨脂、山楂、连翘、金银花的混合物粉碎，过100-140目筛，置于萃取釜中进行萃取，萃取温度为82□，萃取压力为6MPa，萃取时间为5.2h，收集挥发油，即得混合物的提取物；
2)向提取物中放入牛蒡子苷元，混合均匀后浓缩成浸膏，将浸膏放入真空干燥箱中干燥，得到干膏，干燥温度为51℃，干燥时间为25h；
3)将干膏粉碎，加入药学上可接受的辅料制备成药学上常用的中药组合物。
实施例4
本发明实施例中，一种含有牛蒡子苷元的中药组合物，由以下成分组成：牛蒡子苷元57份、麦冬18份、苍术14份、川穹9份、冰片9份、肉桂9份、枸杞子9份、法半夏3份、玉竹3份、补骨脂3份、山楂9份、连翘9份、金银花9份。
所述含有牛蒡子苷元的中药组合物的制备方法，采用超临界萃取法，具体步骤包括：
1)将麦冬、苍术、川穹、冰片、肉桂、枸杞子、法半夏、玉竹、补骨脂、山楂、连翘、金银花的混合物粉碎，过100-140目筛，置于萃取釜中进行萃取，萃取温度为87□，萃取压力为8MPa，萃取时间为5.7h，收集挥发油，即得混合物的提取物；
2)向提取物中放入牛蒡子苷元，混合均匀后浓缩成浸膏，将浸膏放入真空干燥箱中干燥，得到干膏，干燥温度为54℃，干燥时间为30h；
3)将干膏粉碎，加入药学上可接受的辅料制备成药学上常用的中药组合物。
实施例5
本发明实施例中，一种含有牛蒡子苷元的中药组合物，由以下成分组成：牛蒡子苷元55份、麦冬17份、苍术13份、川穹8份、冰片8份、肉桂8份、枸杞子8份、法半夏2 份、玉竹2份、补骨脂2份、山楂8份、连翘8份、金银花8份。
所述含有牛蒡子苷元的中药组合物的制备方法，采用超临界萃取法，具体步骤包括：
1)将麦冬、苍术、川穹、冰片、肉桂、枸杞子、法半夏、玉竹、补骨脂、山楂、连翘、金银花的混合物粉碎，过100-140目筛，置于萃取釜中进行萃取，萃取温度为85□，萃取压力为7MPa，萃取时间为5.5h，收集挥发油，即得混合物的提取物；
2)向提取物中放入牛蒡子苷元，混合均匀后浓缩成浸膏，将浸膏放入真空干燥箱中干燥，得到干膏，干燥温度为52℃，干燥时间为30h；
3)将干膏粉碎，加入药学上可接受的辅料制备成药学上常用的中药组合物。
实施例6
将上述实施例制得的中药组合物涂抹在有脱发症状的患者的患病部位，每天涂2次，一个疗程为8天，每个实施例的实施患者数量为20名。患者在经过2个疗程的治疗后，观察后患者的脱发情况，脱发现象完全停止为有效例，脱发现象停止并且有新发生出，为特效例，计算有效例和特效例的数量，如表1所示。
表1
  特效例 有效例 无效例
实施例1 13 6 1
实施例2 12 7 1
实施例3 16 4 0
实施例4 17 3 0
实施例5 18 2 0
对于本领域技术人员而言，显然本发明不限于上述示范性实施例的细节，而且在不背离本发明的精神或基本特征的情况下，能够以其他的具体形式实现本发明。因此，无论从哪一点来看，均应将实施例看作是示范性的，而且是非限制性的，本发明的范围由所附权利要求而不是上述说明限定，因此旨在将落在权利要求的等同要件的含义和范围内的所有 变化囊括在本发明内。
此外，应当理解，虽然本说明书按照实施方式加以描述，但并非每个实施方式仅包含一个独立的技术方案，说明书的这种叙述方式仅仅是为清楚起见，本领域技术人员应当将说明书作为一个整体，各实施例中的技术方案也可以经适当组合，形成本领域技术人员可以理解的其他实施方式。

Claims (5)

  1. 一种含有牛蒡子苷元的中药组合物，其特征在于，由以下成分组成：牛蒡子苷元50-60份、麦冬15-20份、苍术10-15份、川穹5-10份、冰片5-10份、肉桂5-10份、枸杞子5-10份、法半夏1-5份、玉竹1-5份、补骨脂1-5份、山楂5-10份、连翘5-10份、金银花5-10份。
  2. 根据权利要求1所述的含有牛蒡子苷元的中药组合物，其特征在于，由以下成分组成：牛蒡子苷元53-57份、麦冬16-18份、苍术12-14份、川穹7-9份、冰片7-9份、肉桂7-9份、枸杞子7-9份、法半夏2-3份、玉竹2-3份、补骨脂2-3份、山楂7-9份、连翘7-9份、金银花7-9份。
  3. 根据权利要求2所述的含有牛蒡子苷元的中药组合物，其特征在于，由以下成分组成：牛蒡子苷元55份、麦冬17份、苍术13份、川穹8份、冰片8份、肉桂8份、枸杞子8份、法半夏2份、玉竹2份、补骨脂2份、山楂8份、连翘8份、金银花8份。
  4. 一种如权利要求1-3任一所述的含有牛蒡子苷元的中药组合物的制备方法，其特征在于，采用超临界萃取法，具体步骤包括：
    1)将麦冬、苍术、川穹、冰片、肉桂、枸杞子、法半夏、玉竹、补骨脂、山楂、连翘、金银花的混合物粉碎，过100-140目筛，置于萃取釜中进行萃取，萃取温度为80-90□，萃取压力为5-10MPa，萃取时间为5-6h，收集挥发油，即得混合物的提取物；
    2)向提取物中放入牛蒡子苷元，混合均匀后浓缩成浸膏，将浸膏放入真空干燥箱中干燥，得到干膏，干燥温度为50-55℃，干燥时间为24-36h；
    3)将干膏粉碎，加入药学上可接受的辅料制备成药学上常用的中药组合物。
  5. 根据权利要求1-3任一所述的含有牛蒡子苷元的中药组合物，其特征在于，用于治疗脱发。
PCT/CN2015/000421 2015-06-11 2015-09-06 一种含有牛蒡子苷元的中药组合物及其制备方法 WO2016197276A1 (zh)

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