WO2016195526A1 - Composition apaisante réduisant l'excitabilité des chats et des chiens en chaleur - Google Patents
Composition apaisante réduisant l'excitabilité des chats et des chiens en chaleur Download PDFInfo
- Publication number
- WO2016195526A1 WO2016195526A1 PCT/RU2015/000349 RU2015000349W WO2016195526A1 WO 2016195526 A1 WO2016195526 A1 WO 2016195526A1 RU 2015000349 W RU2015000349 W RU 2015000349W WO 2016195526 A1 WO2016195526 A1 WO 2016195526A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- theanine
- dogs
- cats
- tryptophan
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 26
- 241000282472 Canis lupus familiaris Species 0.000 title claims abstract description 10
- 241000282326 Felis catus Species 0.000 title claims abstract description 10
- 239000000932 sedative agent Substances 0.000 title abstract description 5
- 230000001624 sedative effect Effects 0.000 title abstract description 5
- 206010001497 Agitation Diseases 0.000 title description 2
- 230000012173 estrus Effects 0.000 title 1
- DATAGRPVKZEWHA-YFKPBYRVSA-N N(5)-ethyl-L-glutamine Chemical compound CCNC(=O)CC[C@H]([NH3+])C([O-])=O DATAGRPVKZEWHA-YFKPBYRVSA-N 0.000 claims abstract description 32
- 241001465754 Metazoa Species 0.000 claims abstract description 20
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims abstract description 19
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims abstract description 17
- 230000001568 sexual effect Effects 0.000 claims abstract description 16
- 229940026510 theanine Drugs 0.000 claims abstract description 9
- 230000037396 body weight Effects 0.000 claims abstract description 6
- 230000001914 calming effect Effects 0.000 claims description 12
- 230000037007 arousal Effects 0.000 claims description 8
- 230000000694 effects Effects 0.000 abstract description 8
- 229960004799 tryptophan Drugs 0.000 description 17
- DATAGRPVKZEWHA-UHFFFAOYSA-N L-gamma-glutamyl-n-ethylamine Natural products CCNC(=O)CCC(N)C(O)=O DATAGRPVKZEWHA-UHFFFAOYSA-N 0.000 description 10
- 235000001014 amino acid Nutrition 0.000 description 10
- 150000001413 amino acids Chemical class 0.000 description 10
- 239000003674 animal food additive Substances 0.000 description 6
- 235000013355 food flavoring agent Nutrition 0.000 description 6
- 239000000546 pharmaceutical excipient Substances 0.000 description 6
- 239000005454 flavour additive Substances 0.000 description 5
- 229940113931 theanine 50 mg Drugs 0.000 description 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 244000269722 Thea sinensis Species 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 235000013312 flour Nutrition 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000004471 Glycine Substances 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 206010029216 Nervousness Diseases 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 239000005862 Whey Substances 0.000 description 2
- 102000007544 Whey Proteins Human genes 0.000 description 2
- 108010046377 Whey Proteins Proteins 0.000 description 2
- 235000006886 Zingiber officinale Nutrition 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000002180 anti-stress Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000035611 feeding Effects 0.000 description 2
- 235000008397 ginger Nutrition 0.000 description 2
- 235000009569 green tea Nutrition 0.000 description 2
- 230000003054 hormonal effect Effects 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000000324 neuroprotective effect Effects 0.000 description 2
- 239000000419 plant extract Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- DATAGRPVKZEWHA-RXMQYKEDSA-N (2r)-2-azaniumyl-5-(ethylamino)-5-oxopentanoate Chemical compound CCNC(=O)CC[C@@H](N)C(O)=O DATAGRPVKZEWHA-RXMQYKEDSA-N 0.000 description 1
- LDCYZAJDBXYCGN-VIFPVBQESA-N 5-hydroxy-L-tryptophan Chemical compound C1=C(O)C=C2C(C[C@H](N)C(O)=O)=CNC2=C1 LDCYZAJDBXYCGN-VIFPVBQESA-N 0.000 description 1
- 229940000681 5-hydroxytryptophan Drugs 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 244000126014 Valeriana officinalis Species 0.000 description 1
- 235000013832 Valeriana officinalis Nutrition 0.000 description 1
- 241000234314 Zingiber Species 0.000 description 1
- 244000273928 Zingiber officinale Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 235000010633 broth Nutrition 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000003433 contraceptive agent Substances 0.000 description 1
- 230000002254 contraceptive effect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000000816 effect on animals Effects 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- LDCYZAJDBXYCGN-UHFFFAOYSA-N oxitriptan Natural products C1=C(O)C=C2C(CC(N)C(O)=O)=CNC2=C1 LDCYZAJDBXYCGN-UHFFFAOYSA-N 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000004895 regional blood flow Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- 235000014268 sports nutrition Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 229940069506 theanine 100 mg Drugs 0.000 description 1
- 235000016788 valerian Nutrition 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
Definitions
- the invention relates to veterinary medicine and animal feeding, namely the production of sedatives for cats and dogs.
- State of the art relates to veterinary medicine and animal feeding, namely the production of sedatives for cats and dogs.
- Veterinary preparations, feed additives and other products for animals are known that have a calming and anti-stress effect that are used, including when excited by sexual hunting (Stop-stress, Cot-Bayun, etc.). They contain as active substances various groups of compounds (plant extracts, pheromone-like substances). However, these funds do not have a fast enough effect and during sexual arousal are used mainly as an additional tool.
- the closest analogue of the invention are chewing tablets for dogs and cats "Anxitane®" (manufactured by Virbac Corporation, France), containing the active ingredient amino acid L-theanine. Tablets promote relaxation, relieve nervousness, anxiety, stress (L. Kern. La transmission de la dairy. In: La Communication. Collection Zoopsychiatrie, Beata C. ed. Marseille, Solal Editeurs, 2005).
- L-Theanine an amino acid that is part of Anxitane®, has a calming and neuroprotective effect on laboratory animals (Vlasov TD, Barkovskaya A.A., Zukhurova M.A., Tsverina V.M. Mechanisms of the neuroprotective effect of green tea component - L-theanine / Regional blood circulation and microcirculation. - 2010.-N 4.- ⁇ .67-71.).
- L-theanine as a sedative in the composition of feed additives, dietary supplements, in sports nutrition, as well as food products.
- Anxitane® does not reduce arousal during sexual hunting in cats and dogs and has a long course of use to achieve a calming effect. Disclosure of invention
- the objective of the invention was the creation on the basis of the amino acid L-theanine sedative for cats and dogs, which, unlike the analogue, has a quick action and effective, including during sexual hunting.
- compositions based on the amino acid L-theanine and additional soothing components in particular glycine, tryptophan, ginger and valerian root, were studied.
- Tests were carried out for each composition on 10 cats and 10 dogs of different ages, sex and different breeds in stressful situations (exhibitions, visits to a veterinarian, etc.), as well as those in arousal caused by sexual hunting. The results are presented in the examples below.
- Excipients lactose, starch, dry whey, talc
- flavor additives up to 0.3 g.
- Tests have shown the calming effect of the composition only in cases where the arousal is not caused by the presence of sexual hunting or sexual arousal.
- the composition did not have a calming effect in 4 cats that were in the period of sexual hunting and in 2 dogs in a state of sexual arousal.
- This composition had a sedative effect in 36% of animals after application for 3 times a day. Almost had no effect on animals that are sexually aroused.
- the composition had a long lasting soothing effect.
- L-Tryptophan is an essential amino acid that, along with other amino acids, is widely used as a feed additive to balance the diets of farm and domestic animals.
- a calming feed additive containing tryptophan (Equilizer (France)) is also known. horses with a pronounced reaction to stress and with increased nervousness.
- tryptophan reduces sexual arousal during sexual hunting in animals.
- the term “Theanine” (L-theanine, 1-thianine, 1-Theanine, 1-teanin) of the present invention is an amino acid derived from glutamic acid ( ⁇ -glutamyl ethylamide), obtained primarily from tea leaves, as well as synthetic and microbiological . Any form of the amino acid L-theanine, D-theanine and DL-theanine can be used, but it is preferable to use the L-form.
- Theanine of the present invention can be used both as an amino acid and as an extract of green tea.
- the tryptophan of the present invention can be 1-tryptophan, 5-hydroxytryptophan, plant extracts containing tryptophan and its derivatives and other biologically active forms of tryptophan and its derivatives obtained by various methods.
- This composition had a calming effect on all animals, but the effect was less pronounced and not long.
- the solution was used in a dose of 5 ml per 10 kg of body weight. Tests have shown that in the form of a solution, the composition is no less effective than the solid form and has a calming effect on all animals.
- the optimal composition is the one containing theanine - 50 mg and tryptophan - 8 mg per 10 kg of animal body weight.
- composition can be incorporated into feed additives, feed, treats and other feed products for cats and dogs. It can be used in combination with well-known auxiliary substances and excipients (lactose, starch, whey, cheese powder, milk flour, vegetable flour, meat flour, sugar syrup, broth and other feed and pharmaceutical ingredients).
- the composition is effective both in the form of solid forms (for example, tablets), and in the composition of liquid feed products.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention se rapporte à la médecine vétérinaire. L'invention concerne une composition apaisante ayant une action de diminution de l'excitation sexuelle chez les chiens et les chats qui contient dans une dose pour 10 kg en poids du corps de l'animal, de 5 à 100 mg de théanine et de 2 à 16 mg de tryptophane. Cette composition normalise le comportement des animaux dans les 30 à 60 minutes suivant l'absorption.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/RU2015/000349 WO2016195526A1 (fr) | 2015-06-03 | 2015-06-03 | Composition apaisante réduisant l'excitabilité des chats et des chiens en chaleur |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/RU2015/000349 WO2016195526A1 (fr) | 2015-06-03 | 2015-06-03 | Composition apaisante réduisant l'excitabilité des chats et des chiens en chaleur |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2016195526A1 true WO2016195526A1 (fr) | 2016-12-08 |
Family
ID=57441297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/RU2015/000349 WO2016195526A1 (fr) | 2015-06-03 | 2015-06-03 | Composition apaisante réduisant l'excitabilité des chats et des chiens en chaleur |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2016195526A1 (fr) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080044499A1 (en) * | 2004-04-06 | 2008-02-21 | Taiyokagaku Co., Ltd. | Sleep Improvement Composition |
| RU2479316C2 (ru) * | 2007-09-04 | 2013-04-20 | Дзе Проктер Энд Гэмбл Компани | Пероральные композиции, продукты и способы применения |
-
2015
- 2015-06-03 WO PCT/RU2015/000349 patent/WO2016195526A1/fr active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080044499A1 (en) * | 2004-04-06 | 2008-02-21 | Taiyokagaku Co., Ltd. | Sleep Improvement Composition |
| RU2479316C2 (ru) * | 2007-09-04 | 2013-04-20 | Дзе Проктер Энд Гэмбл Компани | Пероральные композиции, продукты и способы применения |
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