WO2016183784A1 - 一种用于治疗过敏性鼻炎的中药 - Google Patents

一种用于治疗过敏性鼻炎的中药 Download PDF

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WO2016183784A1
WO2016183784A1 PCT/CN2015/079227 CN2015079227W WO2016183784A1 WO 2016183784 A1 WO2016183784 A1 WO 2016183784A1 CN 2015079227 W CN2015079227 W CN 2015079227W WO 2016183784 A1 WO2016183784 A1 WO 2016183784A1
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allergic rhinitis
chinese medicine
traditional chinese
magnolia
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PCT/CN2015/079227
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French (fr)
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张甘霖
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张甘霖
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/264—Aristolochia (Dutchman's pipe)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)

Definitions

  • the invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine for treating allergic rhinitis.
  • Allergic rhinitis also known as allergic rhinitis, with episodes of nasal itching and continuous sneezing as the main clinical features, often accompanied by flow clearing and nasal congestion.
  • Allergic rhinitis also known as allergic rhinitis, with episodes of nasal itching and continuous sneezing as the main clinical features, often accompanied by flow clearing and nasal congestion.
  • It can induce bronchial asthma, sinusitis, nasal polyps, otitis media, etc., or coincide with allergic conjunctivitis.
  • Modern medicine believes that allergic rhinitis is a specific inflammatory mediator of nasal mucosa involved in the release of IgE-mediated mediators (mainly histamine) after exposure to allergens, and a variety of immune-active cells and cytokines. .
  • Anti-allergic drugs can only alleviate allergic symptoms, can not change allergies, so the condition is easy to recurrent.
  • Allergic rhinitis belongs to the category of "snoring" of traditional
  • Xanthium Laozizi, Congzi, Qufu, Cangtou, Mao Congzi, crazy head, sheep with return.
  • Source This product is the dried and mature fruit of the genus Chrysanthemum. When the autumn fruit matures, it is harvested, dried, and removes impurities such as stems and leaves. Whole grass can also be used as medicine.
  • [Sexual taste] Xin, bitter, warm; [Return] to the lungs, liver.
  • Indications Disperse wind and dehumidification, through the nose. It is used for cold headaches, nasal flow, rash, itching, and wetness.
  • Jiantang 3 ⁇ 9g.
  • the headache of blood deficiency and romance are not allowed.
  • Excerpt "Chinese Materia Medica”.
  • Xinyihua wooden pen flower, spring flower, spring flower, magnolia, purple magnolia, white magnolia, February flower, Guangyulan.
  • This product is a dried flower bud of Magnolia, Magnolia or Magnolia. Harvested at the end of winter and early spring when the flowers are not open, remove the branches and dry.
  • [Sexual taste] Xin, warm. [Return] to the lungs, stomach. [Indications] scattered cold, through the nose. For cold headache, nasal congestion, nose, nose and turbidity.
  • Aconite [alias] attached tablets, salt aconite, black smooth, white attached tablets.
  • This product is a processed product of the root of Aconite of Ranunculaceae. Excavation from the end of June to the beginning of August, removing the mother roots, fibrous roots and sediment, known as "mud aconite", processed into the following varieties.
  • [Sexual taste] Xin, Gan, hot; poisonous.
  • Indications Return to the sun to save the fever, supplement the fire to help the yang, and the wind and cold dampness.
  • Huanren [alias] ⁇ , ⁇ , ⁇ , ⁇ .
  • This product is a dry and mature seed of the grass family. When the fruit is ripe in autumn, the plants are harvested, dried, and the fruits are dried, dried, and the outer shell, yellow-brown seed coat and impurities are removed, and the kernels are collected. [Sexual taste] sweet, light, cool. [Return] to the spleen, stomach, lung. [Indications] Spleen and spleen, in addition to phlegm and diarrhea, clear heat and thick. For edema, athlete's foot, urinary unfavorable, wet sputum, spleen diarrhea, lung sputum, intestinal fistula; flat wart. [Usage and dosage] Oral: Jiantang, 9 ⁇ 30g. [Note] It is difficult for the spleen to be pregnant and pregnant. [Excerpt] "Chinese Materia Medica”.
  • Atractylodes [alias] in surgery, winter surgery, Zhejiang surgery, seed surgery. [Source] This product is the dried atractylodes of Asteraceae Dry roots. In the winter, when the lower leaves are yellow and the upper leaves become brittle, they are excavated, removed from the sediment, dried or dried, and then the roots are removed. [Sexual taste] bitter, sweet, warm. [Return to the spleen] stomach, stomach. [Indications] spleen and qi, dampness and water, antiperspirant, and fetus. For spleen deficiency, less bloating, diarrhea, sputum, edema, edema, spontaneous sweating, fetal movement.
  • the invention aims to provide a traditional Chinese medicine for treating allergic rhinitis, and achieve the purpose of safely and effectively curing allergic rhinitis by selecting an appropriate medicinal material and its ratio.
  • a traditional Chinese medicine for treating allergic rhinitis wherein it is prepared from the following raw materials of weight ratio: 10 parts of Xanthium, 15 parts of Magnolia, 10 parts of ebony, 10 parts of white peony, 5 parts of Asarum 5 parts of aconite, 30 parts of coix seed, 10 parts of Atractylodes.
  • the treatment group was orally administered the capsule prepared according to the specific example 3 of the present invention 3 times a day.
  • the treatment lasts for one month.
  • the control group received oral cetirizine tablets 10 mg once a day. The treatment lasts for one month.
  • the medicine prepared by the invention can safely and effectively treat allergic rhinitis and has the promotion value.

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

一种治疗过敏性鼻炎的中药由以下原料制备而成（重量份数）：苍耳子（10），辛夷花（15），乌梅（10），白芷（10），细辛（5），附子（5），薏苡仁（30），白术（10）。临床实验证明所述中药能够安全有效地治疗过敏性鼻炎。

Description

一种用于治疗过敏性鼻炎的中药 技术领域
本发明涉及一种中药，具体涉及一种用于治疗过敏性鼻炎的中药。
背景技术
过敏性鼻炎又称变应性鼻炎，以发作性鼻痒、连续喷嚏为主要临床特征，常伴流清涕和鼻塞。严重影响现代人的生活质量。并可诱发支气管哮喘、鼻窦炎、鼻息肉、中耳炎等，或与变应性结膜炎同时发生。现代医学认为变应性鼻炎是特异性个体接触致敏原后由IgE介导的介质(主要是组胺)释放，并有多种免疫活性细胞和细胞因子等参与的鼻黏膜慢性炎症反应性疾病。抗过敏药物仅可以缓解过敏症状，不能改变过敏体质，故病情易反复发作。过敏性鼻炎属于中医“鼻鼽”范畴。历代医家多认为“鼻鼽”与肺、脾、肾三脏虚弱，功能失调有关。
本发明所涉及药材研究现状如下：
苍耳子【别名】苍耳、老苍子、苍子、葈耳、苍刺头、毛苍子、痴头猛、羊带归。【来源】本品为菊科植物苍耳的干燥成熟带总苞的果实。秋季果实成熟时采收，干燥，除去梗、叶等杂质。全草亦可入药。【性味】辛、苦，温；【归经】归肺、肝经。【功能主治】散风除湿，通鼻窍。用于风寒头痛，鼻渊流涕，风疹瘙痒，湿痹拘挛。【用法用量】内服：煎汤，3～9g。【注意】血虚之头痛、痹痛忌服。【摘录】《中华本草》。
辛夷花【别名】木笔花、望春花、春花、木兰、紫玉兰、白玉兰、二月花、广玉兰。【来源】本品为木兰科植物望春花、玉兰或武当玉兰的干燥花蕾。冬末春初花未开放时采收，除去枝梗，阴干。【性味】辛，温。【归经】归肺、胃经。【功能主治】散风寒，通鼻窍。用于风寒头痛，鼻塞，鼻渊，鼻流浊涕。【用法用量】内服：煎汤，3～9g。【注意】芎藭为之使。恶五石脂。畏菖蒲、蒲黄、黄连、石膏、黄环。气虚人忌，头脑痛属血虚火炽者忌，齿痛属胃火者忌。【摘录】《中华本草》。
乌梅【别名】酸梅、黄仔、合汉梅、干枝梅。【来源】本品为蔷薇科植物梅的干燥近成熟果实。夏季果实近成熟时采收，低温烘干后闷至色变黑。【性味】酸、涩，平。【归经】归肝、脾、肺、大肠经。【功能主治】敛肺，涩肠，生津，安蛔。用于肺虚久咳，久痢滑肠，虚热消渴，蛔厥呕吐腹痛，胆道蛔虫症。【用法用量】内服：煎汤，6～12g。【注意】咳嗽初起，气实喘促，胸膈痞闷，恐酸以束邪气，戒之。【摘录】《中华本草》。
白芷【别名】薛、芷，芳香，苻蓠、泽芬，白茝，香白芷。【来源】本品为伞型科植物白芷或杭白芷的干燥根。夏、秋间叶黄时采挖，除去须根及泥沙，晒干或低温干燥。【性味】辛，温。【归经】归胃、大肠、肺经。【功能主治】散风除湿，通窍止痛，消肿排脓。用于感冒头痛，眉棱骨痛，鼻塞，鼻渊，牙痛，白带，疮疡肿痛。【用法用量】内服：煎汤，3～9g。【注意】阴虚血热者忌服。当归为之使。恶旋覆花。【摘录】《中华本草》。
细辛【别名】小辛，细草，少辛，独叶草、金盆草，山人参。【来源】本品为马兜铃科植物北细辛、汉城细辛或华细辛的干燥全草。前二种习称“辽细辛”。夏季果熟期或初秋采挖，除去泥沙，阴干。【性味】辛，温。【归经】归心、肺、肾经。【功能主治】祛风散寒，通窍止痛，温肺化饮。用于风寒感冒，头痛，牙痛，鼻塞鼻渊，风湿痹痛，痰饮喘咳。【用法用量】内服：煎汤，1～3g。【注意】不宜与藜芦同用。【摘录】《中华本草》。
附子【别名】附片、盐附子、黑顺片、白附片。【来源】本品为毛茛科植物乌头的子根的加工品。6月下旬至8月上旬采挖，除去母根、须根及泥沙，习称“泥附子”，加工成下列品种。【性味】辛、甘，大热；有毒。【归经】归心、肾、脾经。【功能主治】回阳救逆，补火助阳，逐风寒湿邪。用于亡阳虚脱，肢冷脉微，阳萎，宫冷，心腹冷痛，虚寒吐泻，阴寒水肿，阳虚外感，寒湿痹痛。【用法用量】内服：煎汤，3～15g。【注意】孕妇禁用。不宜与半夏、瓜蒌、天花粉、贝母、白蔹、白及同用。【摘录】《中华本草》。
薏苡仁【别名】薏苡、苡米、薏仁米、沟子米。【来源】本品为禾本科植物薏苡的干燥成熟种仁。秋季果实成熟时采割植株，晒干，打下果实，再晒干，除去外壳、黄褐色种皮及杂质，收集种仁。【性味】甘、淡，凉。【归经】归脾、胃、肺经。【功能主治】健脾渗湿，除痹止泻，清热排浓。用于水肿，脚气，小便不利，湿痹拘挛，脾虚泄泻，肺痈，肠痈；扁平疣.【用法用量】内服：煎汤，9～30g。【注意】脾约便难及妊妇慎服。【摘录】《中华本草》。
白术【别名】于术、冬术、浙术、种术。【来源】本品为菊科植物白术的干 燥根茎。冬季下部叶枯黄、上部叶变脆时采挖，除去泥沙，烘干或晒干，再除去须根。【性味】苦、甘，温。【归经】归脾、胃经。【功能主治】健脾益气，燥湿利水，止汗，安胎。用于脾虚食少，腹胀泄泻，痰饮眩悸，水肿，自汗，胎动不安。土白术健脾，和胃，安胎。用于脾虚食少，泄泻便溏，胎动不安。【用法用量】内服：煎汤，6～12g。【注意】阴虚燥渴，气滞胀闷者忌服。【摘录】《中华本草》。
发明内容
本发明旨在提供一种用于治疗过敏性鼻炎的中药，通过选择合适的药材及其配比，达到安全有效治愈过敏性鼻炎的目的。
为了达到上述目的，本发明采用以下技术方案：
一种用于治疗过敏性鼻炎的中药，其中，它是由以下重量配比的原料药材制备而成：苍耳子10份、辛夷花15份、乌梅10份、白芷10份、细辛5份、附子5份、薏苡仁30份、白术10份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2012年10月～2013年10月间共收集门诊及住院过敏性鼻炎患者101例，随机分为治疗组54例与对照组47例。治疗组男33例，女21例，年龄14～49岁，病程7个月～15年；对照组男27例，女20例，年龄16～52岁，病程9个月～18年。2组性别、年龄及病程比较差异无统计学意义，具有可比性。
诊断标准
依据全国溃疡性结肠炎临床专业会议的诊断标准：(1)鼻痒、喷嚏、鼻分泌物和鼻塞，常年性者在有症状的日子里每日累计达0.5～1h以上。(2)鼻腔检查可见鼻黏膜苍白、水肿或充血、肿胀；花粉症患者往往有明显的结膜充血、肿，严重者眼睑肿胀；发作期鼻分泌物涂片和(或)结膜刮片嗜酸性粒细胞检查阳性；变应原皮肤试验呈阳性反应。
2、试验方法
2.1治疗方法
治疗组口服本发明按照具体实施例3制得的胶囊剂，每日3次。疗程一个月。
对照组口服西替利嗪片10mg 1次/天。疗程一个月。
3、疗效标准与治疗结果
3.1疗效标准
临床控制：症状、体征消失，3月以上无复发；
显效：症状、体征消失，3月以上有复发；
有效：发作时症状及体征减轻，发作次数减少；
无效：症状、体征无明显改善。
3.2治疗结果见表1。
表1两组疗效比较
Figure PCTCN2015079227-appb-000001
可见，本发明制得的药物能够安全有效治疗过敏性鼻炎，具有推广价值。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
实施例1
称取：苍耳子10克、辛夷花15克、乌梅10克、白芷10克、细辛5克、附子5克、薏苡仁30克、白术10克；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120克，即得符合正常成人一天用量的煎剂。
用于治疗过敏性鼻炎。口服，每日分早午晚三次服用。
实施例2
称取：苍耳子10克、辛夷花15克、乌梅10克、白芷10克、细辛5克、附子5克、薏苡仁30克、白术10克；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得符合正常成人一天用量的散剂。
用于治疗过敏性鼻炎。口服，每日分早午晚三次服用。
实施例3
称取：苍耳子10克、辛夷花15克、乌梅10克、白芷10克、细辛5克、 附子5克、薏苡仁30克、白术10克；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗过敏性鼻炎。口服，每日分早午晚三次服用。

Claims (4)

  1. 一种用于治疗过敏性鼻炎的中药，其中，它是由以下重量配比的原料药材制备而成：苍耳子10份、辛夷花15份、乌梅10份、白芷10份、细辛5份、附子5份、薏苡仁30份、白术10份。
  2. 如权利要求1所述的用于治疗过敏性鼻炎的中药，其中，其制备方法为：称取：苍耳子10份、辛夷花15份、乌梅10份、白芷10份、细辛5份、附子5份、薏苡仁30份、白术10份；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120份，即得煎剂；上述份均是指重量份。
  3. 如权利要求1所述的用于治疗过敏性鼻炎的中药，其中，其制备方法为：称取：苍耳子10份、辛夷花15份、乌梅10份、白芷10份、细辛5份、附子5份、薏苡仁30份、白术10份；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得散剂；上述份均是指重量份。
  4. 如权利要求1所述的用于治疗过敏性鼻炎的中药，其中，其制备方法为：称取：苍耳子10份、辛夷花15份、乌梅10份、白芷10份、细辛5份、附子5份、薏苡仁30份、白术10份；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得胶囊剂；上述份均是指重量份。
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CN107496504A (zh) * 2017-09-04 2017-12-22 大连大学 一种治疗过敏性鼻炎的中药复方搽剂及其制备方法
CN108042676A (zh) * 2017-12-29 2018-05-18 南宁市共健源健康科技有限公司 用于过敏性鼻炎的中药制剂及其制备方法
CN110064047A (zh) * 2019-04-23 2019-07-30 深圳前海千水生物科技有限公司 一种植物复合酶鼻腔清毒喷洗剂
CN114028491A (zh) * 2021-12-28 2022-02-11 万粮张生物科技(河南)有限公司 一种治疗鼻甲肿大、鼻黏膜水肿的中药膏及其制备方法

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CN1300605A (zh) * 2000-12-11 2001-06-27 曹保刚 治疗过敏性鼻炎的药物
CN101152253A (zh) * 2007-09-20 2008-04-02 吴月 治疗各种鼻炎的中药
CN104840817A (zh) * 2015-05-18 2015-08-19 西宁科进工业设计有限公司 一种用于治疗过敏性鼻炎的中药

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CN1300605A (zh) * 2000-12-11 2001-06-27 曹保刚 治疗过敏性鼻炎的药物
CN101152253A (zh) * 2007-09-20 2008-04-02 吴月 治疗各种鼻炎的中药
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107496504A (zh) * 2017-09-04 2017-12-22 大连大学 一种治疗过敏性鼻炎的中药复方搽剂及其制备方法
CN108042676A (zh) * 2017-12-29 2018-05-18 南宁市共健源健康科技有限公司 用于过敏性鼻炎的中药制剂及其制备方法
CN110064047A (zh) * 2019-04-23 2019-07-30 深圳前海千水生物科技有限公司 一种植物复合酶鼻腔清毒喷洗剂
CN114028491A (zh) * 2021-12-28 2022-02-11 万粮张生物科技(河南)有限公司 一种治疗鼻甲肿大、鼻黏膜水肿的中药膏及其制备方法
CN114028491B (zh) * 2021-12-28 2022-09-09 万粮张生物科技(河南)有限公司 一种治疗鼻甲肿大的中药膏及其制备方法

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