WO2016177013A1 - 姜黄素及其药用盐的应用 - Google Patents
姜黄素及其药用盐的应用 Download PDFInfo
- Publication number
- WO2016177013A1 WO2016177013A1 PCT/CN2016/000188 CN2016000188W WO2016177013A1 WO 2016177013 A1 WO2016177013 A1 WO 2016177013A1 CN 2016000188 W CN2016000188 W CN 2016000188W WO 2016177013 A1 WO2016177013 A1 WO 2016177013A1
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- Prior art keywords
- acid
- curcumin
- tumor
- use according
- preparation
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- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 title claims abstract description 126
- 235000012754 curcumin Nutrition 0.000 title claims abstract description 63
- 229940109262 curcumin Drugs 0.000 title claims abstract description 63
- 239000004148 curcumin Substances 0.000 title claims abstract description 63
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 title claims abstract description 63
- 150000003839 salts Chemical class 0.000 title claims abstract description 24
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- 208000011580 syndromic disease Diseases 0.000 claims abstract description 30
- 230000000259 anti-tumor effect Effects 0.000 claims abstract description 24
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- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 9
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- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 9
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- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 3
- 235000011054 acetic acid Nutrition 0.000 claims description 3
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- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 3
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- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 claims description 3
- 235000019260 propionic acid Nutrition 0.000 claims description 3
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 3
- 239000011975 tartaric acid Substances 0.000 claims description 3
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/10—Natural spices, flavouring agents or condiments; Extracts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/21—Plant extracts
- A23V2250/2112—Curcumin, turmeric
Definitions
- the incidence of various tumor anemias was 81% for gynecologic tumors, 77% for lung cancer, 73% for lymphoma and myeloma, 61% for gastrointestinal tumors, 62% for breast cancer, and 51% for genitourinary tumors.
- Chemotherapy has a significant relationship with the incidence of anemia and the degree of anemia. Coiffier et al.'s survey of more than 1,000 cancer patients showed that the incidence of anemia began to increase after one month of chemotherapy, and that patients who received chemotherapy for 10 to 12 months experienced moderate (hemoglobin 8). ⁇ 10.0g / dl) or severe (hemoglobin ⁇ 8.0g / dl) anemia in more than 50%. Effective control and treatment of anemia-related tumor-related syndromes is of great significance in the comprehensive treatment of tumors.
- the tumor is fibrosarcoma or non-small cell lung cancer.
- the preparation form of the anti-tumor related syndrome drug is a liquid preparation, a granule, a tablet, a granule, a capsule, a capsule, a sustained release preparation, an orally disintegrating preparation or an injection.
- the curcumin pharmaceutically acceptable salt is a salt formed by curcumin and an organic acid.
- the present invention simultaneously performs the same experimental study as the above experiment with the non-small cell lung cancer A549 as a tumor model, and obtains almost identical results.
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (10)
- 姜黄素及其药用盐在制备抗肿瘤相关性综合症药物中的应用。
- 如权利要求1所述的应用,其特征在于,所述肿瘤为纤维肉瘤或非小细胞肺癌。
- 如权利要求1所述的应用,其特征在于,所述抗肿瘤相关性综合症药物的制剂形式为液体制剂、颗粒剂、片剂、冲剂、胶丸、胶囊、缓释剂、口崩制剂或注射剂。
- 如权利要求1-3任一项所述的应用,其特征在于,所述姜黄素药用盐为姜黄素与无机酸形成的盐。
- 如权利要求4所述的应用,其特征在于,所述无机酸为盐酸、氢溴酸、硫酸、硝酸和磷酸中任一种或几种。
- 如权利要求1-3任一项所述的应用,其特征在于,所述姜黄素药用盐为姜黄素与有机酸形成的盐。
- 如权利要求6所述的应用,其特征在于,所述有机酸为甲酸、乙酸、丙酸、草酸、丙二酸、琥珀酸、富马酸、马来酸、乳酸、苹果酸、酒石酸、柠檬酸、苦味酸、甲磺酸和甲基苯磺酸中任一种或几种。
- 如权利要求1-3任一项所述的应用,其特征在于,所述姜黄素药用盐为姜黄素与酸性氨基酸的酸形成的盐。
- 如权利要求8所述的应用,其特征在于,所述酸性氨基酸为天门氨酸或谷氨酸。
- 以姜黄素为主要成分的植物在制备抗肿瘤相关性综合症药物或食品中的应用。
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2017558371A JP2018515505A (ja) | 2015-05-06 | 2016-04-11 | クルクミン及びその薬用塩の応用 |
US15/572,066 US20180214391A1 (en) | 2015-05-06 | 2016-04-11 | Use of curcumin and pharmaceutically acceptable salt thereof |
EP16789007.8A EP3292865A1 (en) | 2015-05-06 | 2016-04-11 | Use of curcumin and pharmaceutically acceptable salt thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510227963.XA CN105311004B (zh) | 2015-05-06 | 2015-05-06 | 姜黄素及其药用盐的应用 |
CN201510227963.X | 2015-05-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2016177013A1 true WO2016177013A1 (zh) | 2016-11-10 |
Family
ID=55239970
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CN2016/000188 WO2016177013A1 (zh) | 2015-05-06 | 2016-04-11 | 姜黄素及其药用盐的应用 |
Country Status (5)
Country | Link |
---|---|
US (1) | US20180214391A1 (zh) |
EP (1) | EP3292865A1 (zh) |
JP (1) | JP2018515505A (zh) |
CN (1) | CN105311004B (zh) |
WO (1) | WO2016177013A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2018159852A1 (ja) * | 2017-03-03 | 2019-12-26 | 三栄源エフ・エフ・アイ株式会社 | クルクミン含有製剤 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105311004B (zh) * | 2015-05-06 | 2018-12-11 | 江苏靶标生物医药研究所有限公司 | 姜黄素及其药用盐的应用 |
CN109942395B (zh) * | 2019-03-29 | 2021-09-21 | 四川大学 | 一种姜黄素类离子液体及其应用 |
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CN1994286A (zh) * | 2006-12-29 | 2007-07-11 | 神威药业有限公司 | 总姜黄素在制备预防及延缓慢性肾功能衰竭药物中的应用 |
CN103404667A (zh) * | 2013-08-19 | 2013-11-27 | 北京绿源求证科技发展有限责任公司 | 一种改善营养性贫血的食品养血茶冲剂 |
CN105311004A (zh) * | 2015-05-06 | 2016-02-10 | 江苏靶标生物医药研究所有限公司 | 姜黄素及其药用盐的应用 |
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JP2004075666A (ja) * | 2002-05-15 | 2004-03-11 | Keio Gijuku | 造血器腫瘍の治療薬、免疫抑制剤、およびp53を標的分子とする分子標的治療薬 |
WO2004000229A2 (en) * | 2002-06-24 | 2003-12-31 | Research Development Foundation | Treatment of human multiple myeloma by curcumin |
JP2014148474A (ja) * | 2013-01-31 | 2014-08-21 | Chube Univ | Glp−1分泌促進剤 |
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CN1994286A (zh) * | 2006-12-29 | 2007-07-11 | 神威药业有限公司 | 总姜黄素在制备预防及延缓慢性肾功能衰竭药物中的应用 |
CN103404667A (zh) * | 2013-08-19 | 2013-11-27 | 北京绿源求证科技发展有限责任公司 | 一种改善营养性贫血的食品养血茶冲剂 |
CN105311004A (zh) * | 2015-05-06 | 2016-02-10 | 江苏靶标生物医药研究所有限公司 | 姜黄素及其药用盐的应用 |
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JPWO2018159852A1 (ja) * | 2017-03-03 | 2019-12-26 | 三栄源エフ・エフ・アイ株式会社 | クルクミン含有製剤 |
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CN105311004A (zh) | 2016-02-10 |
EP3292865A1 (en) | 2018-03-14 |
CN105311004B (zh) | 2018-12-11 |
US20180214391A1 (en) | 2018-08-02 |
JP2018515505A (ja) | 2018-06-14 |
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