WO2016152225A1 - Puce de mesure de fluides corporels et ensemble dispositif de mesure de composants - Google Patents

Puce de mesure de fluides corporels et ensemble dispositif de mesure de composants Download PDF

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Publication number
WO2016152225A1
WO2016152225A1 PCT/JP2016/051761 JP2016051761W WO2016152225A1 WO 2016152225 A1 WO2016152225 A1 WO 2016152225A1 JP 2016051761 W JP2016051761 W JP 2016051761W WO 2016152225 A1 WO2016152225 A1 WO 2016152225A1
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Prior art keywords
flow path
boundary
respect
chip
thickness direction
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PCT/JP2016/051761
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English (en)
Japanese (ja)
Inventor
嘉哉 佐藤
健行 森内
雅夫 滝浪
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テルモ株式会社
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator

Definitions

  • the present invention relates to a body fluid measurement chip and a component measurement device set, and in particular, even when the body fluid as a specimen has a high viscosity (particularly, whole blood having a high hematocrit value),
  • the present invention relates to a body fluid measurement chip and a component measurement device set that can quickly flow into a flow path portion provided with a reagent.
  • a component measuring apparatus for measuring a predetermined component in a body fluid such as blood or urine has been widely used (for example, see Patent Documents 1 and 2).
  • this type of component measuring device there is a colorimetric component measuring device that optically measures the degree of coloration when a body fluid such as blood is injected into a body fluid measuring chip having a reagent and the reagent and the body fluid are reacted. It is known (see, for example, Patent Document 3).
  • This colorimetric component measuring device includes a chip mounting portion on which a body fluid measurement chip is mounted, an irradiation unit that irradiates a reaction product of a body fluid and a reagent, and a measurement light that is transmitted through or reflected from the reaction product. And a processing unit for processing a signal obtained from the measurement light.
  • Such a component measuring apparatus needs to set a small cross-sectional area of the flow path portion where the reagent is provided due to the limitation of the sample amount.
  • a body fluid measurement chip has a problem in that when measuring a component in a highly viscous body fluid (particularly, whole blood having a high hematocrit value), the component cannot be measured accurately.
  • the present inventors surprisingly found that the high-viscosity bodily fluid has a body fluid measuring chip 700 as shown in FIG. Even when supplied to the supply port 10, if the inner diameter (width and thickness direction distance) of the flow path 20 is small and constant, it cannot quickly flow into the flow path portion 20 b provided with the reagent 30. (See FIG. 9B).
  • an object of the present invention is to provide a body fluid measurement chip capable of quickly flowing a body fluid having a high viscosity into a flow channel portion provided with a reagent even when the body fluid as a specimen has a high viscosity. It is to provide a component measuring device set.
  • a bodily fluid measurement chip is a bodily fluid measurement chip that can be attached to a component measurement device that measures a predetermined component in a bodily fluid.
  • a cross-sectional area of the flow path when the position of the upstream end of the reagent in the flow path is a boundary. And the downstream side is reduced from the upstream side.
  • the distance in the chip thickness direction of the flow path is decreased on the downstream side from the upstream side across the boundary. It is preferable.
  • the width of the flow path in the direction orthogonal to the chip thickness direction sandwiches the boundary, and the upstream It is preferable that the downstream side is decreased from the side.
  • the distance in the chip thickness direction of the flow channel on the upstream side with respect to the boundary is 80 ⁇ m or more.
  • a component measuring device set as a second aspect of the present invention is a component measuring device set comprising a body fluid measuring chip as a first aspect of the present invention and a component measuring device for measuring a predetermined component in body fluid.
  • the component measuring device includes an irradiation unit that irradiates light to a reaction product of the body fluid and the reagent, a light receiving unit that receives measurement light transmitted through the reaction product or reflected from the reaction product, and the measurement light. And a processing unit for processing the obtained signal.
  • the body fluid measurement chip and the component measurement capable of quickly flowing the high viscosity body fluid into the flow path portion provided with the reagent A device set can be provided.
  • FIG. 1 It is a top view which shows the bodily fluid measurement chip
  • FIG. 9 is a photograph showing a state after blood inflow (3 seconds after blood with a hematocrit value of 70) flows in a flow path portion provided with a reagent in a blood inflow experiment using the body fluid measurement chip shown in FIG. 8.
  • the yellowish green part in a photograph is a flow-path part into which the blood does not flow in, and a reddish brown part is blood.
  • Body fluid measurement chip Body fluid measurement chip
  • an embodiment of a body fluid measurement chip according to the present invention will be described with reference to FIGS.
  • symbol is attached
  • FIG. 1 is a plan view showing a body fluid measurement chip according to an embodiment of the present invention.
  • 2A is a cross-sectional view taken along line II in FIG.
  • FIG. 2B is a cross-sectional view showing a modification of the body fluid measurement chip shown in FIG.
  • FIG. 3 is a cross-sectional view showing another modification of the body fluid measurement chip shown in FIG.
  • FIG. 4 is a plan view showing still another modification of the body fluid measurement chip shown in FIG.
  • the body fluid measurement chip 100 in this embodiment includes a supply port 10, a flow path 20, and a reagent 30.
  • the body fluid measuring chip 100 includes a first base material 1 that forms a bottom surface portion, a second base material 2 that forms a top surface portion, and the first base material 1 and the second base material 2.
  • Adhesives 3 and 4 are provided between the base materials 2 and at both ends in the width direction orthogonal to the chip thickness direction.
  • the first base material 1 and the first base material 1 and the second base material 2 are sandwiched with a spacer (not shown) having an arbitrary thickness.
  • a spacer not shown
  • the gap of the predetermined size becomes a flow path 20 having the supply port 10 formed at one end, and body fluid can flow into the body fluid measurement chip 100.
  • a reagent 30 is provided in the flow path 20.
  • a material of the 1st base material 1 According to the objective (light irradiation and light reception), it can select suitably, for example, a polyethylene terephthalate (PET), polymethylmethacrylate, polystyrene, And transparent organic resin materials such as cyclic polyolefin, cyclic olefin copolymer, and polycarbonate; transparent inorganic materials such as glass and quartz; and the like.
  • PET polyethylene terephthalate
  • transparent organic resin materials such as cyclic polyolefin, cyclic olefin copolymer, and polycarbonate
  • transparent inorganic materials such as glass and quartz; and the like.
  • the objective light irradiation / light reception
  • transparent organic resin materials such as a hydrophilic treatment polyester film, etc. are mentioned. It is done.
  • the thickness of the bonding portions 3 and 4 is appropriately adjusted in order to set the distance in the chip thickness direction of the flow path 20 to a desired value.
  • a spacer having an arbitrary thickness is disposed between the first base material and the second base material and then bonded or fused, or the spacer is used as an adhesive member for bonding the first base material and the second base material. You may use the double-sided tape which serves as a function.
  • the reagent 30 is not particularly limited as long as it reacts with body fluids, and can be appropriately selected according to the purpose.
  • the reagent 30 is a known color that reacts with blood to give a color corresponding to the blood glucose concentration. Reagents, and the like.
  • reagent 30 is formed on the first base material 1 by a known method such as coating, but is not limited thereto, and is provided in the flow channel 20 without closing the flow channel 20. It only has to be.
  • the cross-sectional area of the flow channel 20 is The downstream side is decreased from the upstream side across the boundary B.
  • the cross-sectional area of the flow path 20 is such that the downstream side is smaller than the upstream side across the boundary B” means, for example, the cross-sectional area A1 of the flow path 20 (20a) on the upstream side with respect to the boundary B. (Not shown) means that it is larger than the cross-sectional area A2 (not shown) of the flow path 20 (20b) on the downstream side with respect to the boundary B.
  • the “boundary B” is “the position of the upstream end 30a of the reagent 30”. In other words, “the channel portion 20a where the reagent 30 is not provided” and “the reagent 30”. This is a boundary with the flow path portion 20b "provided. Therefore, the reagent 30 is not provided on the upstream side of the boundary B, and the reagent 30 is provided on the downstream side of the boundary B.
  • a step X as a cross-sectional area changing portion may be formed between the flow path portion 20a and the flow path portion 20b.
  • the taper part Y as a cross-sectional area change part straddling the flow-path part 20a and the flow-path part 20b may be formed.
  • the second base material 2 that forms the flow path portion 20a is in line contact with the second base material 2 that forms the flow path portion 20b.
  • the present invention is not limited to this. As shown in FIG.
  • the second base material 2 that forms the flow path portion 20a and the second base material 2 that forms the flow path portion 20b may overlap and overlap each other.
  • the boundary B and the position of the cross-sectional area change portion do not necessarily match as shown in FIG. 2A, and may be in the vicinity even if they are shifted as shown in FIG. 2B. .
  • the cross-sectional area A1 of the channel 20 (20a) on the upstream side with respect to the boundary B means “the boundary B or a portion located in the vicinity thereof in the channel portion 20a where the reagent 30 is not provided”.
  • the boundary B and the position of the cross-sectional area changing portion (step X) coincide with each other.
  • “cross-sectional area A1” is “a cross-sectional area of a portion of the flow path portion 20a not provided with the reagent 30 that is closest to the flow path portion 20b provided with the reagent 30”.
  • Cross-sectional area A1 is “the flow path portion 20a where the reagent 30 is not provided.
  • the cross-sectional area A2 of the flow channel 20 (20b) on the downstream side with respect to the boundary B” means “the cross-sectional area located at or near the boundary B in the flow channel portion 20b where the reagent 30 is provided”.
  • Cross-sectional area of flow path 20 (20b) after change (after decrease) in the change part for example, when the boundary B and the position of the cross-sectional area change part (step X) coincide as shown in FIG. 2A
  • Cross-sectional area A2 is “the cross-sectional area of the flow channel portion 20b provided with the reagent 30 that is closest to the flow channel portion 20a provided with no reagent 30”. As shown in FIG.
  • the cross-sectional area A1 of the flow path 20 (20a) on the upstream side with respect to the boundary B is not particularly limited as long as it is larger than the cross-sectional area A2 of the flow path 20 (20b) on the downstream side with respect to the boundary B.
  • it can be selected appropriately according to the above, 0.1 mm 2 to 0.5 mm 2 is preferable, and 0.13 mm 2 to 0.42 mm 2 is more preferable.
  • the cross-sectional area A2 of the flow path 20 (20b) on the downstream side with respect to the boundary B is not particularly limited as long as it is smaller than the cross-sectional area A1 of the flow path 20 (20a) on the upstream side with respect to the boundary B. Although it can be appropriately selected depending on the thickness, 0.05 mm 2 to 0.2 mm 2 is preferable, and 0.08 mm 2 to 0.16 mm 2 is more preferable.
  • the ratio (A1 / A2) between the cross-sectional area A1 and the cross-sectional area A2 is not particularly limited as long as it is larger than 1, and can be appropriately selected according to the purpose, but is preferably 1.6 to 2.6. When the ratio is within a preferable range, a highly viscous body fluid as a specimen can be quickly flowed into the flow path portion 20b.
  • the position of the upstream end 30a of the reagent 30 in the flow path 20 is defined as the boundary B as shown in FIGS.
  • This distance is preferably such that the downstream side is smaller than the upstream side across the boundary B.
  • “the distance in the chip thickness direction of the flow path 20 is smaller on the downstream side than the upstream side across the boundary B” means, for example, that of the flow path 20 (20a) on the upstream side with respect to the boundary B
  • the distance D1 in the chip thickness direction is larger than the distance D2 in the chip thickness direction of the flow path 20 (20b) on the downstream side with respect to the boundary B.
  • the distance D1 in the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B is not particularly limited and may be appropriately selected depending on the intended purpose, but is preferably 80 ⁇ m or more, and preferably 130 ⁇ m to 1 mm. More preferably, 130 ⁇ m to 200 ⁇ m is particularly preferable.
  • the distance D1 in the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B is larger, it becomes possible to quickly cause a highly viscous body fluid as a specimen to flow into the flow path portion 20b. This is advantageous in that the measurement time can be shortened.
  • a smaller distance D1 in the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B is advantageous in that the sample amount can be reduced. Therefore, the upper limit and the lower limit of the distance D1 are determined in consideration of the balance between the flow of the sample into the flow path portion 20b and the sample amount.
  • the distance D2 in the chip thickness direction of the flow path 20 (20b) on the downstream side with respect to the boundary B is not particularly limited and may be appropriately selected depending on the intended purpose, but is preferably 50 ⁇ m to 100 ⁇ m.
  • the distance D2 in the chip thickness direction of the flow path 20 (20b) on the downstream side with respect to the boundary B is larger, it becomes possible to quickly flow a highly viscous body fluid as a specimen into the flow path portion 20b. It is advantageous in that the measurement time can be shortened, and the smaller one is advantageous in that transmitted light can be obtained efficiently and the amount of specimen can be further reduced.
  • the upper limit and the lower limit of the distance D2 are determined in consideration of the balance between the inflow of the sample into the flow channel portion 20b, the sample amount, and the obtained transmitted light amount. Note that, by reducing the amount of the sample, it is possible to prevent the sample flowing into the flow path portion 20b from scattering the measurement light and accurately measure a predetermined component in the body fluid.
  • the thickness T of the reagent 30 formed on the first substrate 1 is not particularly limited and may be appropriately selected depending on the intended purpose, but is preferably 15 ⁇ m to 30 ⁇ m.
  • the position of the upstream end 30 a of the reagent 30 in the flow path 20 is defined as the boundary B, it is orthogonal to the chip thickness direction of the flow path 20.
  • the width in the direction is preferably such that the downstream side is smaller than the upstream side across the boundary B.
  • “the width of the flow path 20 in the direction perpendicular to the chip thickness direction is smaller on the downstream side than the upstream side across the boundary B”
  • the width W1 in the direction orthogonal to the chip thickness direction of the path 20 (20a) is larger than the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) on the downstream side with respect to the boundary B.
  • the width in the direction perpendicular to the chip thickness direction means “to the chip thickness direction (see FIGS. 2 and 3)” and the flow channel longitudinal direction (see FIGS. 1 to 4).
  • the width W1 and the width W2 in FIGS. 1 and 4 are applicable.
  • the width W1 in the direction orthogonal to the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B is not particularly limited and may be appropriately selected depending on the intended purpose. Is preferred.
  • the larger the width W1 in the direction orthogonal to the chip thickness direction of the channel 20 (20a) on the upstream side with respect to the boundary B the faster the sample can flow into the channel portion 20b.
  • the smaller one is advantageous, and the smaller one is advantageous in that the sample amount can be reduced. Therefore, the upper limit and the lower limit of the width W1 are determined in consideration of the balance between the flow of the sample into the flow channel portion 20b and the sample amount.
  • the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) on the downstream side with respect to the boundary B is not particularly limited and may be appropriately selected depending on the intended purpose. ⁇ 2 mm is preferred.
  • the larger the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) on the downstream side with respect to the boundary B the larger the area of the irradiation spot can be taken in the width direction. It is advantageous in that the measurement can be performed, and the smaller one is advantageous in that the amount of the sample can be reduced. Therefore, the upper limit and the lower limit of the width W2 are determined in consideration of the balance between the area of the irradiation spot and the sample amount.
  • the length L1 in the direction (flow channel longitudinal direction) orthogonal to the chip thickness direction of the flow channel 20 (20a) on the upstream side with respect to the boundary B is not particularly limited and may be appropriately selected depending on the purpose. However, 5 mm to 10 mm is preferable.
  • the longer length L1 in the direction (flow channel longitudinal direction) perpendicular to the chip thickness direction of the flow channel 20 (20a) on the upstream side with respect to the boundary B is attached to the component measuring device ( This is advantageous in that it is easy to insert) and the entry of ambient light into the optical measurement unit is reduced.
  • the shorter one is advantageous in that the amount of specimen can be reduced. Therefore, the upper limit and the lower limit of the length L1 are determined in consideration of the ease of mounting (insertion) on the component measuring apparatus, the influence of ambient light, and the balance of the sample amount.
  • the length L2 in the direction (flow channel longitudinal direction) orthogonal to the chip thickness direction of the flow channel 20 (20b) on the downstream side with respect to the boundary B is not particularly limited and may be appropriately selected depending on the purpose. However, 1 mm to 4 mm is preferable, and 1 mm to 2 mm is more preferable.
  • the longer one of the length L2 in the direction (flow channel longitudinal direction) perpendicular to the chip thickness direction of the flow channel 20 (20b) on the downstream side with respect to the boundary B is the length of the irradiation spot area. Since it can be greatly taken in the direction, it is advantageous in that the measurement can be performed with high accuracy, but the shorter one is advantageous in that the amount of the sample can be reduced. Therefore, the upper limit and the lower limit of the length L2 are determined in consideration of the balance between the measurement accuracy and the sample amount.
  • a component measuring device set as an embodiment of the present invention includes the above-described body fluid measuring chip of the present invention and a component measuring device that measures a predetermined component in the body fluid.
  • a component measurement device set including a transmission-type component measurement device that measures light transmitted through a reaction product of a body fluid and a reagent will be described, the present invention is not limited to this, for example, the reaction It may be a component measuring device set including a reflection type component measuring device that measures light reflected from an object.
  • FIG. 5 shows a blood glucose meter set 500 as a component measuring device set according to an embodiment of the present invention.
  • the blood glucose meter set 500 includes a blood glucose meter 110 and a blood glucose measurement chip 100a as the body fluid measurement chip 100.
  • the blood glucose measurement chip 100a is attached to the tip of the blood glucose meter 110.
  • the blood glucose meter 110 includes a display 111 for displaying measurement results and operation details, a power button 112 for instructing activation and termination of the blood glucose meter 110, an operation button 113, a removal lever 114 for removing the blood glucose measurement chip 100a, It has.
  • the display 111 is composed of a liquid crystal or LED.
  • FIG. 6 is a longitudinal sectional view showing separately the tip of the blood glucose meter 110 of the blood glucose meter set 500 and the blood glucose measurement chip 100a.
  • a mounting portion 22 having an opening 21 formed at the tip of the blood glucose meter 110 is provided, and a mounting hole 23 for mounting the blood glucose measuring chip 100a is defined inside the blood glucose meter 110.
  • a predetermined component of a body fluid collected in the blood glucose measurement chip 100a (this embodiment will be described mainly using blood as an example) (this embodiment will be described mainly using a blood glucose level as an example).
  • An optical measurement unit 24 is provided for measuring.
  • the blood glucose meter 110 includes a processing unit 25 that processes a signal obtained from the measurement light and calculates a blood glucose level, and an eject pin 26 that removes the blood glucose measurement chip 100a in conjunction with the removal lever 114.
  • a processing unit 25 that processes a signal obtained from the measurement light and calculates a blood glucose level
  • an eject pin 26 that removes the blood glucose measurement chip 100a in conjunction with the removal lever 114.
  • the blood glucose measuring chip 100a When measuring, the blood glucose measuring chip 100a is mounted in the mounting hole 23.
  • the mounting operation is performed manually by the user.
  • an appropriate lock mechanism or the like for fixing the blood glucose measurement chip 100a to a predetermined position in the mounting hole 23 is preferably installed.
  • the optical measurement unit 24 includes an irradiation unit 31 that irradiates light to a reaction product of a reagent and blood, and a light receiving unit 32 that receives light transmitted through the reaction product as measurement light.
  • a light emitting diode LED
  • a halogen lamp, a laser, or the like may be used.
  • a photodiode (PD) is used for the light receiving unit 32.
  • the light receiving unit 32 may be any device that can convert received light into a predetermined signal, and may be a CCD, a CMOS, or the like.
  • the irradiation unit 31 includes a first light emitting element 51 that emits light having a first wavelength, and a second light emitting element 52 that emits light having a second wavelength different from the first wavelength.
  • the first wavelength is a wavelength for detecting the degree of color development according to the blood glucose level, and is in the wavelength band of 600 to 900 nm, for example.
  • the second wavelength is a wavelength for detecting the concentration of red blood cells in blood, and is in the wavelength band of 510 to 590 nm, for example.
  • the arrangement of the irradiation unit 31 and the light receiving unit 32 and the positional relationship between them will be described.
  • a first space 41 and a second space 42 are formed inside the blood glucose meter 110.
  • the irradiation unit 31 is disposed in the first space 41
  • the light receiving unit 32 is disposed in the second space 42.
  • the first space 41 and the second space 42 face each other with the attachment hole 23 therebetween (see FIG. 6).
  • the first space 41 and the second space 42 sandwich the position where the reagent 30 on the blood glucose measurement chip 100a is held. opposite.
  • the irradiation part 31 is arrange
  • a spectral filter may be provided to extract only a specific wavelength as the irradiation light 33.
  • a method including a condensing lens is also suitable for effective implementation with low-energy irradiation.
  • the processing unit 25 includes a calculation unit 25A that calculates a blood glucose level based on a signal obtained from the measurement light, and a prediction unit 25B that predicts a predetermined range including the blood glucose level based on a signal obtained from the measurement light. Including.
  • First base material 1 Polyethylene terephthalate (PET) film (manufacturing company name: Toray Industries, Inc., trade name: Lumirror T60, thickness: 188 ⁇ m)
  • Second base material 2 hydrophilic treatment polyester film (manufacturer name: 3M company, trade name: hydrophilic treatment polyester film 9901P, thickness: 100 ⁇ m)
  • Adhesion part 3 4: Double-sided tape (manufacturer name: 3M company, product name: polyester film substrate, double-sided adhesive tape 9965, thickness: 80 ⁇ m)
  • Reagent 30 Mixture of WST-4 (manufacturer name: Dojindo Laboratories), m-PMS (manufacturer name:
  • ⁇ Blood inflow experiment> The prepared blood sample 6 mm 3 is supplied to the supply port of the prepared body fluid measurement chip, and the state after blood inflow (3 seconds after blood inflow) in the flow path portion 20b provided with the reagent 30 is observed. Evaluation was performed according to the following evaluation criteria. The evaluation results are shown in Table 1. -Evaluation criteria- ⁇ : Blood completely flowed into the flow path portion 20b (for example, FIG. 7B). (Triangle
  • Comparative Example 2 In Comparative Example 1, (1) the first base material 1: the length of the polyethylene terephthalate (PET) film is 8 mm, (2) the second base material 2: the length of the hydrophilic polyester film is 8 mm, ( 3) Adhering portions 3 and 4: The length of the double-sided tape is 8 mm, and (9) the direction perpendicular to the chip thickness direction of the flow channel 20 (20a) on the upstream side with respect to the boundary B (flow channel longitudinal direction) (1) First base material 1: Polyethylene terephthalate (PET) film length is 11 mm, and (2) Second base material 2: length of hydrophilic treated polyester fill Length: 11 mm, (3) Adhesive part 3, 4: Double-sided tape length is 11 mm, and (9) Direction perpendicular to the chip thickness direction of the flow path 20 (20a) upstream from the boundary B (Flow channel longitudinal direction) Except that the L1 and 9mm is, in the same manner as in Comparative Example 1, preparation of the body fluid measuring chip, the preparation of the specimen
  • Example 1 In Comparative Example 1, a bodily fluid measurement chip having the configuration shown in the plan view of FIG. 1 and the cross-sectional view of FIG. 8 is prepared, and the distance D1 in the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B is set. Instead of 80 ⁇ m, a bodily fluid measurement chip having the configuration shown in the plan view of FIG. 1 and the cross-sectional view of FIG. In the same manner as in Comparative Example 1, except that the thickness was set to 130 ⁇ m, the preparation of the body fluid measurement chip, the preparation of the specimen, and the blood inflow experiment were performed. The evaluation results are shown in Table 1.
  • Example 2 In Comparative Example 2, a body fluid measurement chip having the configuration shown in the plan view of FIG. 1 and the cross-sectional view of FIG. 8 is prepared, and the distance D1 in the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B is set. Instead of 80 ⁇ m, a body fluid measurement chip having the configuration shown in the plan view of FIG. 1 and the cross-sectional view of FIG. 2 is prepared, and the distance D1 in the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B was prepared in the same manner as in Comparative Example 2 except that the body fluid measurement chip was prepared, the sample was prepared, and the blood inflow experiment was performed. The evaluation results are shown in Table 1.
  • Example 3 In Comparative Example 1, a bodily fluid measurement chip having the configuration shown in the plan view of FIG. 1 and the cross-sectional view of FIG. 8 is prepared, and the distance D1 in the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B is set. Instead of 80 ⁇ m, a bodily fluid measurement chip having the configuration shown in the plan view of FIG. 1 and the cross-sectional view of FIG. The sample was prepared for the body fluid measurement chip, the sample was prepared, and the blood inflow experiment was conducted in the same manner as in Comparative Example 1 except that the thickness was set to 160 ⁇ m. The evaluation results are shown in Table 1.
  • Example 4 In Comparative Example 2, a body fluid measurement chip having the configuration shown in the plan view of FIG. 1 and the cross-sectional view of FIG. 8 is prepared, and the distance D1 in the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B is set. Instead of 80 ⁇ m, a body fluid measurement chip having the configuration shown in the plan view of FIG. 1 and the cross-sectional view of FIG. 2 is prepared, and the distance D1 in the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B In the same manner as in Comparative Example 2 except that the thickness was set to 160 ⁇ m, the preparation of the body fluid measurement chip, the preparation of the specimen, and the blood inflow experiment were performed. The evaluation results are shown in Table 1.
  • Example 5 In Comparative Example 1, a bodily fluid measurement chip having the configuration shown in the plan view of FIG. 1 and the cross-sectional view of FIG. 8 is prepared, and the distance D1 in the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B is set. Instead of 80 ⁇ m, a body fluid measurement chip having the configuration shown in the plan view of FIG. 1 and the cross-sectional view of FIG. 2 is prepared, and the distance D1 in the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B The preparation of the body fluid measurement chip, the preparation of the sample, and the blood inflow experiment were performed in the same manner as in Comparative Example 1 except that the thickness was 210 ⁇ m. The evaluation results are shown in Table 1.
  • Example 6 In Comparative Example 2, a body fluid measurement chip having the configuration shown in the plan view of FIG. 1 and the cross-sectional view of FIG. 8 is prepared, and the distance D1 in the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B is set. Instead of 80 ⁇ m, a body fluid measurement chip having the configuration shown in the plan view of FIG. 1 and the cross-sectional view of FIG. 2 is prepared, and the distance D1 in the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B
  • the preparation of the body fluid measurement chip, the preparation of the sample, and the blood inflow experiment were performed in the same manner as in Comparative Example 2 except that the thickness was 210 ⁇ m. The evaluation results are shown in Table 1.
  • Comparative Example 3 In Comparative Example 1, (12) the width W1 in the direction orthogonal to the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B is 1 mm, and (13) on the downstream side with respect to the boundary B. Instead of setting the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) to 1 mm, (12) with respect to the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B Comparative example except that the width W1 in the orthogonal direction is 2 mm and (13) the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) on the downstream side with respect to the boundary B is 2 mm. In the same manner as in Example 1, preparation of a body fluid measurement chip, preparation of a specimen, and blood inflow experiment were performed. The evaluation results are shown in Table 1.
  • Comparative Example 4 In Comparative Example 2, (12) the width W1 in the direction orthogonal to the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B is set to 1 mm, and (13) on the downstream side with respect to the boundary B. Instead of setting the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) to 1 mm, (12) with respect to the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B Comparative example except that the width W1 in the orthogonal direction is 2 mm and (13) the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) on the downstream side with respect to the boundary B is 2 mm. In the same manner as in Example 2, preparation of a body fluid measurement chip, preparation of a sample, and blood inflow experiment were performed. The evaluation results are shown in Table 1.
  • Example 7 In Example 1, (12) the width W1 in the direction orthogonal to the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B is set to 1 mm, and (13) on the downstream side with respect to the boundary B. Instead of setting the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) to 1 mm, (12) with respect to the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B Example 13 except that the width W1 in the orthogonal direction is 2 mm and (13) the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) on the downstream side with respect to the boundary B is 2 mm. In the same manner as in Example 1, preparation of a body fluid measurement chip, preparation of a specimen, and blood inflow experiment were performed. The evaluation results are shown in Table 1.
  • Example 8 the width W1 in the direction orthogonal to the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to (12) the boundary B is set to 1 mm, and (13) on the downstream side with respect to the boundary B.
  • the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) is set to 1 mm, and (13) on the downstream side with respect to the boundary B.
  • the width W1 in the orthogonal direction is 2 mm and (13) the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) on the downstream side with respect to the boundary B is 2 mm.
  • Example 9 the width W1 in the direction orthogonal to the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to (12) the boundary B is set to 1 mm, and (13) on the downstream side with respect to the boundary B.
  • the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) is set to 1 mm, and (13) on the downstream side with respect to the boundary B.
  • the width W1 in the orthogonal direction is 2 mm and (13) the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) on the downstream side with respect to the boundary B is 2 mm.
  • Example 10 the width W1 in the direction orthogonal to the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to (12) the boundary B is set to 1 mm, and (13) on the downstream side with respect to the boundary B.
  • the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) is set to 1 mm, and (13) on the downstream side with respect to the boundary B.
  • the width W1 in the orthogonal direction is 2 mm and (13) the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) on the downstream side with respect to the boundary B is 2 mm.
  • Example 11 In Example 5, (12) the width W1 in the direction orthogonal to the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B is set to 1 mm, and (13) on the downstream side with respect to the boundary B.
  • the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) is set to 1 mm, and (13) on the downstream side with respect to the boundary B.
  • the width W1 in the orthogonal direction is 2 mm and (13) the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) on the downstream side with respect to the boundary B is 2 mm.
  • Example 12 the width W1 in the direction orthogonal to the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B is set to 1 mm, and (13) on the downstream side with respect to the boundary B.
  • the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) is set to 1 mm, and (13) on the downstream side with respect to the boundary B.
  • the width W1 in the orthogonal direction is 2 mm and (13) the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) on the downstream side with respect to the boundary B is 2 mm.
  • Example 13 In Example 1, (1) the first base material 1: the length of the polyethylene terephthalate (PET) film is 8 mm, (2) the second base material 2: the length of the hydrophilic treated polyester film: 8 mm, ( 3) Adhering portions 3 and 4: The length of the double-sided tape is 8 mm, and (10) the direction perpendicular to the chip thickness direction of the flow channel 20 (20b) on the downstream side with respect to the boundary B (flow channel longitudinal direction) (1) First base material 1: Polyethylene terephthalate (PET) film length is 9 mm, and (2) Second base material 2: length of hydrophilic treated polyester fill Length: 9 mm, (3) Adhesive part 3, 4: Double-sided tape length is 9 mm, (10) Direction perpendicular to chip thickness direction of flow path 20 (20b) on the downstream side with respect to boundary B Length of (flow channel longitudinal direction) Except that 2 was a 3 mm, in the same manner as in Example 1, preparation of the body fluid measuring chip, the preparation of the sample
  • Example 14 In Example 2, (1) 1st base material 1: The length of a polyethylene terephthalate (PET) film shall be 11 mm, (2) 2nd base material 2: The length of a hydrophilic treatment polyester fill: 11 mm, ( 3) Adhering portions 3 and 4: The length of the double-sided tape is 11 mm, and (10) the direction perpendicular to the chip thickness direction of the flow channel 20 (20b) on the downstream side with respect to the boundary B (flow channel longitudinal direction) (1) First base material 1: Polyethylene terephthalate (PET) film length is 12 mm, and (2) Second base material 2: length of hydrophilic treated polyester fill Length: 12 mm, (3) Adhesive part 3, 4: Double-sided tape length is 12 mm, (10) Direction orthogonal to chip thickness direction of flow path 20 (20b) on the downstream side with respect to boundary B (Flow path length Except that the length L2 of the direction) was set to 3 mm, in the same manner as in Example 2, preparation of the body fluid measurement chip, the
  • Example 15 In Example 3, (1) the first base material 1: the length of the polyethylene terephthalate (PET) film is 8 mm, (2) the second base material 2: the length of the hydrophilic treated polyester film: 8 mm, ( 3) Adhering portions 3 and 4: The length of the double-sided tape is 8 mm, and (10) the direction perpendicular to the chip thickness direction of the flow channel 20 (20b) on the downstream side with respect to the boundary B (flow channel longitudinal direction) (1) First base material 1: Polyethylene terephthalate (PET) film length is 9 mm, and (2) Second base material 2: length of hydrophilic treated polyester fill Length: 9 mm, (3) Adhesive part 3, 4: Double-sided tape length is 9 mm, (10) Direction perpendicular to chip thickness direction of flow path 20 (20b) on the downstream side with respect to boundary B Length of (flow channel longitudinal direction) Except that 2 was a 3 mm, in the same manner as in Example 3, preparation of the body fluid measuring chip, the preparation of the sample
  • Example 16 In Example 4, (1) 1st base material 1: The length of a polyethylene terephthalate (PET) film shall be 11 mm, (2) 2nd base material 2: The length of a hydrophilic treatment polyester fill: 11 mm, ( 3) Adhering portions 3 and 4: The length of the double-sided tape is 11 mm, and (10) the direction perpendicular to the chip thickness direction of the flow channel 20 (20b) on the downstream side with respect to the boundary B (flow channel longitudinal direction) (1) First base material 1: Polyethylene terephthalate (PET) film length is 12 mm, and (2) Second base material 2: length of hydrophilic treated polyester fill Length: 12 mm, (3) Adhesive part 3, 4: Double-sided tape length is 12 mm, (10) Direction orthogonal to chip thickness direction of flow path 20 (20b) on the downstream side with respect to boundary B (Flow path length Except that the length L2 of the direction) was set to 3 mm, in the same manner as in Example 4, preparation of the body fluid measuring chip, the
  • Example 17 In Example 5, (1) 1st base material 1: The length of a polyethylene terephthalate (PET) film shall be 8 mm, (2) 2nd base material 2: The length of a hydrophilic treatment polyester fill: 8 mm, ( 3) Adhering portions 3 and 4: The length of the double-sided tape is 8 mm, and (10) the direction perpendicular to the chip thickness direction of the flow channel 20 (20b) on the downstream side with respect to the boundary B (flow channel longitudinal direction) (1) First base material 1: Polyethylene terephthalate (PET) film length is 9 mm, and (2) Second base material 2: length of hydrophilic treated polyester fill Length: 9 mm, (3) Adhesive part 3, 4: Double-sided tape length is 9 mm, (10) Direction perpendicular to chip thickness direction of flow path 20 (20b) on the downstream side with respect to boundary B Length of (flow channel longitudinal direction) Except that 2 was a 3 mm, in the same manner as in Example 5, preparation of the body fluid measuring chip, the
  • Example 18 In Example 6, (1) 1st base material 1: The length of a polyethylene terephthalate (PET) film shall be 11 mm, (2) 2nd base material 2: The length of a hydrophilic treatment polyester fill: 11 mm, ( 3) Adhering portions 3 and 4: The length of the double-sided tape is 11 mm, and (10) the direction perpendicular to the chip thickness direction of the flow channel 20 (20b) on the downstream side with respect to the boundary B (flow channel longitudinal direction) (1) First base material 1: Polyethylene terephthalate (PET) film length is 12 mm, and (2) Second base material 2: length of hydrophilic treated polyester fill Length: 12 mm, (3) Adhesive part 3, 4: Double-sided tape length is 12 mm, (10) Direction orthogonal to chip thickness direction of flow path 20 (20b) on the downstream side with respect to boundary B (Flow path length Except that the length L2 of the direction) was set to 3 mm, in the same manner as in Example 6, preparation of the body fluid measurement chip, the
  • Comparative Example 7 In Comparative Example 5, (12) the width W1 in the direction orthogonal to the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B is 1 mm, and (13) on the downstream side with respect to the boundary B. Instead of setting the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) to 1 mm, (12) with respect to the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B Comparative example except that the width W1 in the orthogonal direction is 2 mm and (13) the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) on the downstream side with respect to the boundary B is 2 mm.
  • preparation of a body fluid measurement chip, preparation of a specimen, and blood inflow experiment were performed. The evaluation results are shown in Table 1.
  • Example 19 In Example 13, (12) the width W1 in the direction orthogonal to the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B is set to 1 mm, and (13) on the downstream side with respect to the boundary B. Instead of setting the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) to 1 mm, (12) with respect to the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B Example 13 except that the width W1 in the orthogonal direction is 2 mm and (13) the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) on the downstream side with respect to the boundary B is 2 mm. In the same manner as in Example 13, preparation of a body fluid measurement chip, preparation of a sample, and blood inflow experiment were performed. The evaluation results are shown in Table 1.
  • Example 20 In Example 14, (12) the width W1 in the direction orthogonal to the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B is 1 mm, and (13) on the downstream side with respect to the boundary B.
  • the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) is 1 mm
  • (12) with respect to the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B Example 13 except that the width W1 in the orthogonal direction is 2 mm and (13) the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) on the downstream side with respect to the boundary B is 2 mm.
  • preparation of a body fluid measurement chip, preparation of a specimen, and blood inflow experiment were performed. The evaluation results are shown in Table 1.
  • Example 21 In Example 15, (12) the width W1 in the direction orthogonal to the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B is set to 1 mm, and (13) on the downstream side with respect to the boundary B.
  • the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) is set to 1 mm, and (13) on the downstream side with respect to the boundary B.
  • the width W1 in the orthogonal direction is 2 mm and (13) the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) on the downstream side with respect to the boundary B is 2 mm.
  • body fluid measurement chip preparation, sample preparation, and blood inflow experiment were performed. The evaluation results are shown in Table 1.
  • Example 22 In Example 16, (12) the width W1 in the direction orthogonal to the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B is set to 1 mm, and (13) on the downstream side with respect to the boundary B.
  • the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) is set to 1 mm, and (13) on the downstream side with respect to the boundary B.
  • the width W1 in the orthogonal direction is 2 mm and (13) the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) on the downstream side with respect to the boundary B is 2 mm.
  • Example 23 In Example 17, (12) the width W1 in the direction orthogonal to the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B is set to 1 mm, and (13) on the downstream side with respect to the boundary B.
  • the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) is set to 1 mm, and (13) on the downstream side with respect to the boundary B.
  • the width W1 in the orthogonal direction is 2 mm and (13) the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) on the downstream side with respect to the boundary B is 2 mm.
  • Example 24 In Example 18, (12) the width W1 in the direction orthogonal to the chip thickness direction of the flow path 20 (20a) on the upstream side with respect to the boundary B is set to 1 mm, and (13) on the downstream side with respect to the boundary B.
  • the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) is set to 1 mm, and (13) on the downstream side with respect to the boundary B.
  • the width W1 in the orthogonal direction is 2 mm and (13) the width W2 in the direction orthogonal to the chip thickness direction of the flow path 20 (20b) on the downstream side with respect to the boundary B is 2 mm.
  • Example 25 In Comparative Example 7, a body fluid measurement chip having the configuration shown in the plan view of FIG. 1 and the cross-sectional view of FIG. 8 is prepared, and (13) in the chip thickness direction of the flow path 20 (20b) on the downstream side with respect to the boundary B. Instead of setting the width W2 in the direction orthogonal to 2 mm, a bodily fluid measurement chip having the configuration shown in the plan view of FIG. 4 and the cross-sectional view of FIG. 8 is prepared. (13) The preparation of the body fluid measurement chip, the preparation of the sample, and the blood inflow experiment were performed in the same manner as in Comparative Example 7, except that the width W2 in the direction orthogonal to the chip thickness direction of the channel 20 (20b) was set to 1 mm. It was. The evaluation results are shown in Table 1.
  • Example 26 In Comparative Example 8, a bodily fluid measurement chip having the configuration shown in the plan view of FIG. 1 and the cross-sectional view of FIG. 8 is prepared. (13) In the chip thickness direction of the flow path 20 (20b) on the downstream side with respect to the boundary B Instead of setting the width W2 in the direction orthogonal to 2 mm, a bodily fluid measurement chip having the configuration shown in the plan view of FIG. 4 and the cross-sectional view of FIG. 8 is prepared. (13) The preparation of the body fluid measurement chip, the preparation of the sample, and the blood inflow experiment were performed in the same manner as in Comparative Example 8 except that the width W2 in the direction orthogonal to the chip thickness direction of the channel 20 (20b) was set to 1 mm. It was. The evaluation results are shown in Table 1.
  • the present invention relates to a body fluid measurement chip and a component measurement device set, and in particular, even when the body fluid as a specimen has a high viscosity (particularly, whole blood having a high hematocrit value),
  • the present invention relates to a body fluid measurement chip and a component measurement device set that can quickly flow into a flow path portion provided with a reagent.
  • Adhesion part 4 Adhesion part 10: Supply port 20: Channel 20a: Channel part 20b without a reagent: Channel part with a reagent 21: Opening part 22: Mounting part 23: Mounting hole 24: Optical measurement part 25: Processing part 25A: Calculation part 25B: Prediction part 26: Eject pin 30: Reagent 30a: Upstream end 31: Irradiation part 32: Light receiving part 33 : Irradiation light 41: First space 42: Second space 51: First light emitting element 52: Second light emitting element 100: Body fluid measurement chip 100a: Blood glucose measurement chip 110: Blood glucose meter 111: Display 112: Power button 113: Operation button 114: Detach lever 500: Blood glucose meter set (component measuring device) 700: Body fluid measurement chip B: Boundary D1: Distance in the chip thickness direction of the channel on the upstream side with respect to the boundary D2: Distance L1 in the chip thickness direction of the channel on the downstream side with

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Abstract

Cette invention concerne une puce de mesure de fluides corporels (100) pouvant se monter dans un dispositif de mesure de composants (500) qui mesure les composants prédéfinis d'un fluide corporel, ledit dispositif comprenant un orifice d'introduction (10) dans lequel un fluide corporel est introduit, une voie d'écoulement (20) à une extrémité de laquelle l'orifice d'introduction (10) est formé, et un réactif (30) qui est introduit dans la voie d'écoulement (20). Quand la position de l'extrémité côté amont (30a) du réactif (30) dans la voie d'écoulement (20) est traitée comme une bordure (B), l'aire de la section transversale de la voie d'écoulement (20) est inférieure côté aval à celle côté amont de la bordure (B).
PCT/JP2016/051761 2015-03-24 2016-01-15 Puce de mesure de fluides corporels et ensemble dispositif de mesure de composants WO2016152225A1 (fr)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019012865A1 (fr) * 2017-07-14 2019-01-17 テルモ株式会社 Puce de mesure du niveau de glycémie et ensemble dispositif de mesure du niveau de glycémie
WO2019138681A1 (fr) * 2018-01-15 2019-07-18 テルモ株式会社 Système de mesure de composant, dispositif de mesure et pointe de mesure
WO2020137532A1 (fr) * 2018-12-28 2020-07-02 テルモ株式会社 Bandelette de test et système de mesure de composant

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008126403A1 (fr) * 2007-04-05 2008-10-23 Panasonic Corporation Puce analytique à liquide échantillon
WO2008136473A1 (fr) * 2007-04-29 2008-11-13 Arkray, Inc. Instrument d'analyse
JP2009031102A (ja) * 2007-07-26 2009-02-12 Panasonic Corp 試料分析チップ
JP2011141302A (ja) * 2003-12-04 2011-07-21 Panasonic Corp ヘマトクリット（Ｈｃｔ）の測定方法およびそれに用いるセンサならびに測定装置
WO2014049704A1 (fr) * 2012-09-26 2014-04-03 テルモ株式会社 Embout de mesure

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011141302A (ja) * 2003-12-04 2011-07-21 Panasonic Corp ヘマトクリット（Ｈｃｔ）の測定方法およびそれに用いるセンサならびに測定装置
WO2008126403A1 (fr) * 2007-04-05 2008-10-23 Panasonic Corporation Puce analytique à liquide échantillon
WO2008136473A1 (fr) * 2007-04-29 2008-11-13 Arkray, Inc. Instrument d'analyse
JP2009031102A (ja) * 2007-07-26 2009-02-12 Panasonic Corp 試料分析チップ
WO2014049704A1 (fr) * 2012-09-26 2014-04-03 テルモ株式会社 Embout de mesure

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110291185B (zh) * 2017-07-14 2022-08-09 泰尔茂株式会社 血糖值测定芯片及血糖值测定装置套组
JP7184770B2 (ja) 2017-07-14 2022-12-06 テルモ株式会社 血糖値測定チップ及び血糖値測定装置セット
CN110291185A (zh) * 2017-07-14 2019-09-27 泰尔茂株式会社 血糖值测定芯片及血糖值测定装置套组
US20200124610A1 (en) * 2017-07-14 2020-04-23 Terumo Kabushiki Kaisha Blood glucose level measuring chip and blood glucose level measuring device set
JPWO2019012865A1 (ja) * 2017-07-14 2020-05-07 テルモ株式会社 血糖値測定チップ及び血糖値測定装置セット
US11719701B2 (en) 2017-07-14 2023-08-08 Terumo Kabushiki Kaisha Blood glucose level measuring chip and blood glucose level measuring device set
JP2022186748A (ja) * 2017-07-14 2022-12-15 テルモ株式会社 血糖値測定チップ及び血糖値測定装置セット
WO2019012865A1 (fr) * 2017-07-14 2019-01-17 テルモ株式会社 Puce de mesure du niveau de glycémie et ensemble dispositif de mesure du niveau de glycémie
CN111630375A (zh) * 2018-01-15 2020-09-04 泰尔茂株式会社 成分测定系统、测定装置以及测定芯片
JPWO2019138681A1 (ja) * 2018-01-15 2021-01-14 テルモ株式会社 成分測定システム、測定装置及び測定チップ
WO2019138681A1 (fr) * 2018-01-15 2019-07-18 テルモ株式会社 Système de mesure de composant, dispositif de mesure et pointe de mesure
JP7241033B2 (ja) 2018-01-15 2023-03-16 テルモ株式会社 成分測定システム及び測定装置
JPWO2020137532A1 (ja) * 2018-12-28 2021-11-11 テルモ株式会社 テストストリップ及び成分測定システム
WO2020137532A1 (fr) * 2018-12-28 2020-07-02 テルモ株式会社 Bandelette de test et système de mesure de composant
JP7442461B2 (ja) 2018-12-28 2024-03-04 テルモ株式会社 成分測定システム

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