WO2016116580A1 - Composition nutritionnelle utile dans le traitement de patients atteints d'une ibd - Google Patents

Composition nutritionnelle utile dans le traitement de patients atteints d'une ibd Download PDF

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Publication number
WO2016116580A1
WO2016116580A1 PCT/EP2016/051275 EP2016051275W WO2016116580A1 WO 2016116580 A1 WO2016116580 A1 WO 2016116580A1 EP 2016051275 W EP2016051275 W EP 2016051275W WO 2016116580 A1 WO2016116580 A1 WO 2016116580A1
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WIPO (PCT)
Prior art keywords
composition
nutritional composition
free form
ibd
acid
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Application number
PCT/EP2016/051275
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English (en)
Inventor
Stéphanie Blum-Sperisen
Magali Faure
Denis Breuille
Emil CHUANG
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Nestec S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nestec S.A. filed Critical Nestec S.A.
Priority to CN201680004920.8A priority Critical patent/CN107106653A/zh
Priority to JP2017536953A priority patent/JP2018504405A/ja
Priority to BR112017014107A priority patent/BR112017014107A2/pt
Priority to AU2016208455A priority patent/AU2016208455A1/en
Priority to EP16701315.0A priority patent/EP3247343A1/fr
Priority to CA2973433A priority patent/CA2973433A1/fr
Priority to US15/544,088 priority patent/US10137108B2/en
Publication of WO2016116580A1 publication Critical patent/WO2016116580A1/fr
Priority to HK18105261.1A priority patent/HK1245658A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
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    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A—HUMAN NECESSITIES
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Definitions

  • the invention relates to a nutritional composition that is useful in the treatment of inflammatory bowel disease (IBD) patients. Further, the invention relates to a nutritional composition that is suitable in the prevention or postponement of a relapse in inflammatory bowel disease patients.
  • IBD inflammatory bowel disease
  • IBD Inflammatory bowel disease
  • CD Crohn's disease
  • UC ulcerative colitis
  • IBD Intra-detiology
  • a subset of commensal enteric bacteria in a genetically susceptible host with disease initiated by environmental triggers.
  • sustained intestinal infections, mucosal barrier defects, mucosal immune dysregulation, and genetic and environmental factors all seem to contribute to the disease process.
  • anti-inflammatory drugs like corticosteroid drugs or mesalazine, antibiotics and, in very severe cases surgery are the preferred choices for treating IBD. While in some cases the above described drugs can already induce clinical remission and reduce intestinal symptoms of IBD, an acute resurgence/re lapse of the symptoms can appear following treatment. For example, in children, Crohn's disease has a chronic relapsing course in which up to 50% of the patients eventually need surgery (Davies, G et al; 1990; Br. J. Surg.; 77: 81-94). The natural clinical course of inflammatory bowel disease (IBD) is characterized by episodes of relapse and remission.
  • IBD inflammatory bowel disease
  • the main treatment goal in IBD is to induce and maintain remission by effective control of the gut inflammatory process.
  • the assessment of the level of resolution of the inflammatory process at the intestinal level remains uncertain in the current clinical practice.
  • Subclinical inflammation and incomplete mucosal healing may still persist at the end of a therapeutic cycle that otherwise can be considered successful from a clinical point of view.
  • An "incomplete" biological remission of the inflammatory process is supposed to represent a higher risk for earlier relapse.
  • IBD inflammatory bowel disease
  • Escherichia coli has been shown to stimulate the release of proinflammatory cytokines, whereas other bacterial species such as Lactobacillus casei and L. plantarum downregulate the expression of proinflammatory cytokines and prevent mucosal damage.
  • prebiotics such as oligosaccharides and probiotics (live nonpathogenic bacteria) in animals and healthy human subjects has proven effective for altering the gut microbiome, suggesting that these strategies may be useful in IBD.
  • a nutritional composition comprising (a) the amino acids threonine, serine, and proline in free form, (b) carbohydrates and proteins comprising whey TGF-Beta, and (c) at least one essential fatty acid.
  • a nutritional composition comprising (a) the amino acids threonine, serine, and proline in free form, (b) carbohydrates and proteins comprising whey TGF- Beta, and (c) at least one essential fatty acid for use in the treatment of inflammatory bowel disease (IBD).
  • IBD inflammatory bowel disease
  • a nutritional composition comprising (a) the amino acids threonine, serine, and proline in free form, (b) carbohydrates and proteins comprising whey TGF- Beta, and (c) at least one essential fatty acid for use in prolonging remission of IBD in an IBD patient.
  • a nutritional composition comprising (a) the amino acids threonine, serine, and proline in free form, (b) carbohydrates and proteins comprising whey TGF- Beta, and (c) at least one essential fatty acid for use in in maintaining or improving the mucosa health status of an IBD patient.
  • composition of the invention may be administered for at least 10, 20, 24, 30, 40, 42, 50, or 60 weeks.
  • a composition accord to the invention is efficacious with respect to the medical indications of claim 2. a, 2.b, or 2.c for at least 10, 20, 24, 30, 40, 42, 50, or 60 weeks or at a time point selected from any time point between 10 and 60 weeks, between 10 and 50 weeks, between 20 and 50 weeks, between 20 and 30 weeks, or between 40 and 50 weeks.
  • the IBD is Crohn's Disease (CD) or ulcerative colitis (UC).
  • the IBD is CD.
  • the composition of the invention may be administered in combination with a medicament effective against IBD, said medicament preferably being an immunosuppressant, preferably a combination of infliximab and adalimumab, or 5-aminosalicylic acid (5-ASA).
  • the composition according to the invention is in the form of a dry powder formulation.
  • the composition according to the invention in the form of a dry powder formulation comprises 9.0-1 l .Og threonine in free form, 7.0-9.0g proline in free form, and 7.0- 9.0g serine in free form, per lOOg of powder formulation.
  • composition according to the invention in the form of a dry powder formulation comprises 20-200 meg whey TGF-Beta /100 g.
  • the composition according to the invention comprises at least one essential fatty acid is selected from the group consisting of alpha-linolenic acid, linolenic acid, eicosapentaenoic acid, and docosahexaenoic acid, or combinations thereof.
  • the composition according to the invention in the form of a dry powder formulation comprises 0.1 - 1.0 g alpha-linolenic acid/100 g, 1.0 - 8.0 g linolenic acid/ 100 g, 0.01 g - 0.2 g eicosapentaenoic acid /100 g, and 0.005 - 0.200 g docosahexaenoic acid /100 g.
  • the dry powder formulation is reconstituted in water.
  • the composition of the invention is in the form of a liquid composition.
  • the composition of the invention is in the form of a ready-to-drink, formulation.
  • the composition of the invention in the form of a liquid composition comprises 1.0-3.0 g threonine in free form /100ml, 1.0-2.5 g serine in free form/100ml, and 1.0 - 2.5 g proline in free form/100 ml.
  • the composition of the invention in the form of a liquid composition comprises 10-80 meg whey TGF -Beta/100 ml.
  • the essential fatty acids are selected from the group consisting of alpha- linolenic acid, linolenic acid, eicosapentaenoic acid, and docosahexaenoic acid or combinations thereof.
  • a kit comprising: a first container comprising (a) the amino acids threonine, serine, and proline in free form, and (b) protein and essential fatty acids; and a second container comprising whey TGF-Beta.
  • a method of treating IBD comprising administrating to a patient in need thereof a nutritional composition comprising (a) the amino acids threonine, serine, and proline in free form, (b) carbohydrates and proteins comprising whey TGF-Beta, and (c) at least one essential fatty acid.
  • a method of prolonging remission in an IBD patient comprising administrating to a patient in need thereof a nutritional composition comprising (a) the amino acids threonine, serine, and proline in free form, (b) carbohydrates and proteins comprising whey TGF-Beta, and (c) at least one essential fatty acid.
  • a method of maintaining or improving the mucosa health status of an IBD patient comprising administrating to a patient in need thereof a nutritional composition comprising (a) the amino acids threonine, serine, and proline in free form, (b) carbohydrates and proteins comprising whey TGF-Beta, and (c) at least one essential fatty acid.
  • the invention is directed to a nutritional composition useful for the treatment of IBD or the prevention or postponement of IBD relapse events during remission. All ranges disclosed in this section also cover the integer and/or non-integer values covered by the range.
  • IBD Inflammatory bowel disease
  • IBD refers to diseases which cause inflammation in the digestive tract, including Crohn's disease and ulcerative colitis.
  • the causes of IBD are multifactorial and still not completely understood.
  • IBD-associated symptoms include abdominal cramps/pain, bloody diarrhea and weight loss.
  • IBD is characterized by phases of relapse and remission.
  • Treatment of IBD in the sense of the invention comprises prevention or postponement of IBD during remission.
  • CD Crohn's disease or CD refers to a chronic inflammatory disorder of the gastrointestinal (GI) tract. It may occur in any portion of the GI tract but is most often found to affect the distal small intestine and/or colon. Unlike ulcerative colitis, CD can affect the entire thickness of the bowel wall.
  • the subjects to be treated with the claimed composition are subjects suffering from CD.
  • Ulcerative colitis or UC refers to a chronic disease marked by inflammation and ulceration of the mucosa (innermost lining) of the colon or large intestine.
  • UC differs from CD in that UC involves only the large intestine, the inflammation involves the entire rectum extending up the colon in a continuous manner without areas of normal intestine interspersed with diseased areas, and UC affects only the innermost lining of the colon.
  • Enteral feeding means oral or tube feeding.
  • Milk proteins comprise casein protein and whey protein with the former representing 80% of the milk protein and whey protein 20% of the milk protein.
  • the former representing 80% of the milk protein and whey protein 20% of the milk protein.
  • Casein is found in milk as a suspension of particles called “casein micelles.”
  • the hydrophilic parts reside at the surface and they are spherical.
  • the interior of a casein micelle is highly hydrated.
  • the caseins in the micelles are held together by calcium ions and hydrophobic interactions.
  • Casein proteins comprise alpha-casein, beta-casein, and kappa-casein. Casein proteins are rather insoluble in water.
  • Casein is prepared from whole milk by microfiltration with the casein (casein micelles) remaining in the retentate while the whey protein can be found in the permeate.
  • Whey protein comprises a mixture of beta-lacto globulin (-65%), alpha-lactalbumin (-25%), bovine serum albumin (-8%) and other proteins.
  • Caseinate is prepared by acid precipitation of casein. Caseinate is more soluble in water than casein (i.e. casein micelles).
  • a microbiome is the ecological community of commensal, symbiotic, and pathogenic microorganisms that share our body space.
  • "Microbiome” and “microbiota” are defined to describe either the collective genomes of the microorganisms that reside in an environmental niche or the microorganisms themselves, respectively (The NIH HMP Working Group. 2009. The NIH Human Microbiome Project. Genome Res. 2009 December; 19(12): 2317-2323; Backhed, F; Ley, R.E.; Sonnenburg, J.L.; Peterson, D.A.; Gordon, J.I. 2005. Host-Bacterial Mutualism in the Human Intestine.
  • Nutritional composition can be provided as a powder nutritional composition (dry powder formulation), a liquid nutritional composition, or in the form of kit comprising a liquid nutritional composition comprising one or more components of the nutritional composition in one container and comprising in a further container a powder composition, or a second liquid composition, comprising other component(s) of the nutritional composition.
  • the nutritional compositions of the invention are useful for oral consumption or enteral feeding.
  • the liquid nutritional composition or the reconstituted powder nutritional composition or liquid nutritional composition derived from the kit can have an energy content of 70 - 250 kcal / 100 ml. In an embodiment, the liquid nutritional composition or the reconstituted powder nutritional composition or liquid nutritional composition derived from the kit can have an energy content of 70 - 200 kcal / 100 ml. In an embodiment, the liquid nutritional composition or the reconstituted powder nutritional composition or liquid nutritional composition derived from the kit can have an energy content of 70 - 140 kcal / 100 ml. In a preferred embodiment, the liquid nutritional composition or the reconstituted powder nutritional composition or liquid nutritional composition derived from the kit can have an energy content of 80-130 kcal/ 100 ml.
  • the liquid nutritional composition or the reconstituted powder nutritional composition or liquid nutritional composition derived from the kit can have an energy content of 80 - 120 kcal/lOOml. In an embodiment, the liquid nutritional composition or the reconstituted powder nutritional composition or liquid nutritional composition derived from the kit can have an energy content of 90 - 1 10 kcal/lOOml.
  • the nutritional composition preferably comprises carbohydrates, protein and fat.
  • carbohydrates can provide 10 - 50 energy percent, 20 - 40 energy percent, or 25 - 35 energy percent of the composition; total protein (including free amino acids) can provide 30-60 energy percent, 35 - 55 energy percent, or 40 - 50 energy percent of the composition; and fat can provide 10-40 energy percent, 15 - 35 energy percent, or 18-30 energy percent, or 20-25 energy percent of the composition.
  • carbohydrates can provide 10 - 50 energy percent of the composition; total protein (including amino acids in free form) can provide 30-60 energy of the composition; and fat can provide 10-40 energy percent of the composition.
  • carbohydrates can provide 20 - 40 energy percent of the composition; total protein (including amino acids in free form) can provide 35-55 energy of the composition; and fat can provide 15-35 energy percent of the composition.
  • carbohydrates can provide 25 - 35 energy percent of the composition; total protein (including amino acids in free form) can provide 40-50 energy of the composition; and fat can provide 18-25 energy percent of the composition.
  • the liquid enteral nutritional composition according to the invention may have the form of a complete food, i.e. it can meet all nutritional needs of the user. As such, it preferably contains 1200 to 2500 kcal per daily dosage.
  • the daily dosage amounts are given with respect to a daily energy supply of 2000 kcal to a healthy adult having a body weight of 70 kg. For persons of different condition and different body weight, the levels should be adapted accordingly. It is understood that the average daily energy intake preferably is about 2000 kcal.
  • the complete food can be in the form of multiple dosage units.
  • a liquid enteral nutritional composition according to the invention of 2.0 kcal/ml ,from 4 (250 ml/unit) to 20 (50 ml/unit) per day may be given. .
  • the liquid enteral nutritional composition can also be a food supplement, for example to be used in addition to a non-medical food.
  • the liquid enteral nutritional composition contains per daily dosage less than 1500 kcal, in particular as a supplement, the liquid enteral nutritional composition contains 400 to 1000 kcal per daily dose.
  • the food supplement can be in the form of a single dodage unit per day, or can be in the form of multiple dosage units, e.g. from 2 to 10 dosage units per day.
  • a unit dosage comprises any amount of the liquid enteral nutritional composition according to the invention between 10 ml and 250 ml, the end values of this range included, preferably any amount between 25 ml and 200 ml, the end values of this range included, more preferably any amount between 50 ml and 150 ml, the end values of this range included.
  • a unit dosage comprises about 135 ml. In one embodiment of the present invention, a unit dosage comprises about 125 ml.
  • the composition is provided in a ready to use liquid form and does not require reconstitution or mixing prior to use.
  • the composition according to the invention can be tube fed or administered orally.
  • the composition according to the invention can be provided in a can, in a carton, in a bottle, in a pouch, and/or hang bag.
  • a composition may be provided to a person in need thereof in powder form, suitable for reconstitution using an aqueous solution or water such that the composition according to the invention is produced.
  • the present composition is in the form of a powder, accompanied with instructions to dissolve or reconstitute in an aqueous composition or water to arrive at the liquid nutritional enteral composition according to the present invention.
  • the present liquid nutritional enteral composition may thus be obtained by dissolving or reconstituting a powder, preferably in an aqueous composition, in particular water.
  • the powder nutritional composition after reconstitution in water and the ready to use composition preferably have a viscosity of 10-100 mPa.s.at room temperature.
  • the nutritional composition according to the invention is heat-treated in order to make the composition suitable for commercial use, i.e. the nutritional composition according to the invention is subjected to a heat-treatment such as pasteurization or sterilization such that the microbacterial load is reduced.
  • a heat-treatment such as pasteurization or sterilization such that the microbacterial load is reduced.
  • the composition according to the invention is packaged.
  • the packaging may have any suitable form of a container, for example a sachet, carton, bottle, pouch, cups, tube, beaker, or capsule.
  • the carton or plastic/glass beaker or tube may have a removable cover; a bottle for example for the 80 ml to 250 ml range, and cups for example for the 10 ml to 30 ml range.
  • Another suitable packaging mode is a powder in a container, e.g. a sachet, preferably with instructions to dissolve or reconstitute in an aqueous composition or water.
  • the containers may be packed into a carton.
  • the nutritional composition of the invention comprises the amino acids threonine, serine, and proline both in bound and in free form.
  • the liquid nutritional formulation comprises in toto 1.0 g - 4 g proline / 100 ml. In an embodiment, the liquid nutritional formulation comprises in toto 1.5 g - 3.0 g proline /100 ml. In an embodiment, the liquid nutritional formulation comprises in toto or 1.8 - 2.5 g proline/ 100 ml. In an embodiment, the liquid nutritional formulation comprises 0.6 g - 3.0 g proline in the free form 100 ml. In an embodiment, the liquid nutritional formulation comprises 1.0 g -2.5 g proline in the free form /100 ml. In an embodiment, the liquid nutritional formulation comprises 1.5 - 2.0 g proline in the free form / 100 ml.
  • the liquid nutritional formulation comprises in toto 1.0 g - 4 g serine / 100 ml. In an embodiment, the liquid nutritional formulation comprises in toto 1.5 g - 3.0 g serine/100 ml. In an embodiment, the liquid nutritional formulation comprises in toto, or 1.8 - 2.5 g serine/ 100 ml. In an embodiment, the liquid nutritional formulation comprises 0.6 g - 3.0 g serine in the free form / 100 ml. In an embodiment, the liquid nutritional formulation comprises 1.0 g -2.5 g serine in the free form /100 ml. In an embodiment, the liquid nutritional formulation comprises 1.5 - 2.0 g serine in the free form / 100 ml.
  • the liquid nutritional formulation comprises in toto 1.5 - 4.0 g threonine / 100 ml. In an embodiment, the liquid nutritional formulation comprises 2.0 - 3.5 g threonine /100 ml. In an embodiment, the liquid nutritional formulation comprises 2.2 - 3.0 g threonine/ 100 ml.
  • the liquid nutritional formulation comprises 1.0 - 3.5 g threonine in the free form /100ml In an embodiment, the liquid nutritional formulation comprises 1.5 - 3.0 g threonine in the free form /100 ml. In an embodiment, the liquid nutritional formulation comprises 1.8 - 2.5 g threonine in the free form / 100 ml.
  • the powder nutritional formulation comprises in toto 5.0 - 15.0 g proline/ 100 g. In an embodiment, the powder nutritional formulation comprises 7.0 - 13.0 g proline /100 g. In an embodiment, the powder nutritional formulation comprises 8.5 - 11.0 g proline / 100 g. In an embodiment, the powder nutritional formulation comprises 4.0 - 12.0 g proline in the free form /100g. In an embodiment, the powder nutritional formulation comprises 6.0 - 10.0 g proline in the free form / 100 g. In an embodiment, the powder nutritional formulation comprises 7.0 - 9.0 g proline in the free form / 100 g. In an embodiment, the powder nutritional formulation comprises 7.3 to 8.5g proline in the free form /100g.
  • the powder nutritional formulation comprises in toto 5.0 -15. Og serine / 100 g. In an embodiment, the powder nutritional formulation comprises 7.0 - 13.0 g serine /100 g. In an embodiment, the powder nutritional formulation comprises 8.5 - 11.0 g serine / 100 g.
  • thepowder nutritional formulation comprises 4.0 - 12.0 g serine in the free form /100g. In an embodiment, the powder nutritional formulation comprises 6.0 - 10.0 g serine in the free form /100 g. In an embodiment, the powder nutritional formulation comprises 7.0 - 9.0 g serine in the free form / 100 g. In an embodiment, the powder nutritional formulation comprises 7.5 to 8.7g serine in the free form /lOOg.
  • the powder nutritional formulation comprises in toto 7.0 - 16.0g threonine /100g. In an embodiment, the powder nutritional formulation comprises 9.0 - 14.0 g threonine /100 g. In an embodiment, the powder nutritional formulation comprises or 10.0 - 13.0 g threonine / 100 g. In an embodiment, the powder nutritional formulation comprises 1 1.0 - 12.0 g threonine / 100 g.
  • the powder nutritional formulation comprises 6.0 - 14.0 g threonine in the free form/1 OOg. In an embodiment, the powder nutritional formulation comprises 8.0 - 12.0 g threonine in the free form /100 g. In an embodiment, the powder nutritional formulation comprises 9.0 - 11.0 g threonine in the free form / 100 g. In an embodiment, the powder nutritional formulation comprises 9.4 - 10.4 g threonine in the free form / 100 g.
  • the nutritional composition comprises protein or a protein component, in addition to the amino acids prloine, serine and threonine in free form, wherein one of the proteins is whey TGF-beta.
  • the liquid nutritional composition can comprise in toto 5-20 g protein /100 ml. In an embodiment, the liquid nutritional composition comprises in toto 6-18 g protein /l 00 ml. In an embodiment, the liquid nutritional composition comprises in toto 6-16 g protein /100 ml. In an embodiment, the liquid nutritional composition comprises in toto 8-16 g protein /l 00 ml. In an embodiment, the liquid nutritional composition comprises in toto 8-14 g protein /100 ml of protein.
  • the powder nutritional composition can comprise in toto 20-80 g protein /100 g . In an embodiment, the powder nutritional composition comprises in toto 30-70 g protein /100 g - In an embodiment, the powder nutritional composition comprises in toto or 40-60 g protein /100 g
  • the protein preferably comprises one or more dairy-protein. In a preferred embodiment the protein can comprise micellar casein, caseinate or whey, or any combination thereof.
  • the liquid nutritional composition comprises whey protein.
  • the powder nutritional composition comprises caseinate and whey proteins.
  • Caseinate can be Na-caseinate, Mg-caseinate, K-caseinate, Ca-caseinate or any mixture thereof or combinations thereof such as Na/K-caseinate and Na/Mg caseinate are used as the source of caseinate.
  • Ca-caseinate, or a caseinate comprising Ca is not used when micellar casein is used because micellar casein already contains a sufficient amount of calcium, and the formation of further calcium crystals is not desired.
  • the liquid nutritional composition can comprise 0.5 - 5 g of caseinate /100 ml. In an embodiment, the liquid nutritional composition can comprise 1- 4 g caseinate /100 ml. In an embodiment, the liquid nutritional composition can comprise 1.5 -3.5 g caseinate/100 ml .
  • the powder nutritional composition can comprise 2 -10 g caseinate /100 g In an embodiment, the powder nutritional composition can comprise 3 - 8 g caseinate /100 g . In an embodiment, the powder nutritional composition can comprise 4 - 6 g caseinate/100 g .
  • the liquid nutritional composition can comprise 0.5 - 5 g casein /100 ml. In an embodiment the liquid nutritional composition can comprise 1 - 4 g casein /100 ml. In an embodiment the liquid nutritional composition can comprise 1 -3 g casein 100 ml.
  • the powder nutritional composition can comprise 1 - 8 g casein /100g. In an embodiment the powder nutritional composition can comprise 2 - 7g casein /100 g. In an embodiment the powder nutritional composition can comprise 3 - 6g casein/1 OOg.
  • Whey protein in the sense of the invention is crude whey protein which is obtained by microfiltration or whey protein isolate which is obtained by further filtration steps removing all components except for the protein.
  • Whey protein isolate differs from whey protein in general in that it does not contain any other molecules than water and protein. Whey protein isolate is virtually or factually lactose free, carbohydrate free, fat free, and cholesterol free while whey protein can still contain lactose, carbohydrates, fat or cholesterol.
  • the nutritional compositions of the invention can thus contain whey protein which is crude whey protein or whey protein isolate, or a combination thereof.
  • the liquid nutritional composition can comprise 1 -15g whey protein /100ml.
  • the liquid nutritional composition can comprise 2-10g whey protein /100ml. In an embodiment, the liquid nutritional composition can comprise 3-8g whey protein /100ml. In an embodiment, the liquid nutritional composition can comprise 4-6g whey protein /100ml. . In an embodiment, the powder nutritional composition can comprise 5-50g whey protein/1 OOg. In an embodiment, the powder nutritional composition can comprise 10-40g whey protein 1 OOg. In an embodiment, the powder nutritional composition can comprise 15-30g whey protein/lOOg. In an embodiment, the powder nutritional composition can comprise 20-25g whey protein/lOOg..
  • the weight ratio of micellar casein to caseinate preferably ranges from 90: 10 to 35:65, more preferably from 80:20 to 40:60.
  • micellar casein and/or caseinate can range from 95:5 to 70:30.
  • the osmolarity of the composition can preferably be lower than 900 mOsm/1 , preferably lower than 800 mOsm/1, or lower than 700 mOsm/1.
  • the density of the composition can preferably range between 1.0 g/ml and 1.20 g/ml or between 1.02 g/ml and 1.18 g/ml.
  • the protein component comprises TGF-beta.
  • TGF-beta designates a family of different growth factors, in particular, TGF-beta 1 and TGF-beta 2 which are two homologous forms of TGF-beta. They are homodimeric and consist of two polypeptide chains each containing 1 12 amino-acids which are linked by a disulfide bridge. Their molecular mass is 25,000 Daltons. Cow's milk derived whey contains both TGF-beta 1 or TGF-beta 2.
  • TGF-beta 2 is the main component and represents 90% in weight of TGF-beta found in milk, while TGF-beta 1 , on the other hand, represents 10% in weight of the total TGF-beta content in milk.
  • TGF-beta content in milk can be from 12 to 150 ⁇ g/l in colostrum, from 3.7 to 3.8 ⁇ g/l in crude and pasteurized milk, 4.3 ⁇ g/l in skimmed milk, and 3.7 ⁇ g/l in whey.
  • TGF-beta Biological activities of TGF-beta are numerous, which give to this polypeptide a great therapeutical interest for prevention or treatment of a large variety of diseases or pathologies.
  • TGF-beta is inter alia an anti-inflammatory agent because it decreases pro -inflammatory cytokines production. Thus, it has immunosuppressive properties and inhibits the proliferation of activated T-lymphocytes.
  • TGF-beta is present in whey protein. It is also possible to provide preparations of whey that contain TGF-beta in higher amounts than crude whey. A process for the preparation of whey TGF-beta which comprises both whey TGF-beta 1 and 2 from whey is described European patent application no. EP 0 527 283 which is herewith incorporated by reference.
  • TGF-beta is present in the amounts described in the following:
  • the liquid nutritional composition can preferably comprise 10-80 meg TGF- Beta /100 ml, preferably 20-70 meg TGF-Beta /100 ml, or 30-60 meg TGF-beta/100 ml.
  • the dry powder formulation can preferably comprise 20-200 meg TGF- beta/lOOg, preferably 30-180 meg TGF-beta/ lOOg; or 40-150 meg TGF-beta/100g.
  • the amount of whey TGF-beta can be determined by any standard procedure, in particular, with the means of antibodies against whey TGF-beta in an Enzyme-linked Immunosorbent Assay (ELISA).
  • the nutritional composition comprises oil and, particularly, essential fatty acids.
  • the nutritional composition can comprise essential fatty acids linoleic acid (LA, 18:2n-6), alpha-linolenic acid (ALA, 18:3n-3), docosahexaenoic acid (DHA, 22:6n-3), or eicosapentaenoic acid (EPA, 20:5n-3), or combinations thereof.
  • all of these essential fatty acids are comprised in the nutritional composition.
  • the powder nutritional composition can comprise essential fatty acids in an amount of 0.05 - 0.4 g / lOOg, 0.01 - 0.5 g,/ 100 g, or 0.1 -0.3 g/ 100 g.
  • the powder nutritional composition can comprise alpha-linolenic acid in an amount of 0.05 - 1.75 g/100 g, 0.1 - 1.0 g/100 g, or 0.2 - 0.5 g/ 100 g,. In an embodiment, the powder nutritional composition can comprise linolenic acid in an amount of 0.5 - 9.0 g / 100 g, 1.0 -8.0 g/ 100 g, or 1.5. -5.0 g / 100 g.
  • the powder nutritional composition can comprise eicosapentaenoic acid in an amount of 0.010 g/100 g - 0.200 g/100 g, 0.025 g/100 g - 0.175 g/100 g, or 0.030 g/100 g - 0.150 g/100 g.
  • the powder nutritional composition can comprise docosahexaenoic acid in an amount of 0.005-0.200g / lOOg, 0.01 -0.175g/100g, or 0.010-150g/100g.
  • the liquid nutritional composition can comprise 0.005 - 1.75 g/100 ml, 0.01 - 1.25 g/100 ml, 0.02 - 1.0 g/ 100 ml alpha-lino lenic acid.
  • the liquid nutritional composition can comprise linolenic acid in an amount of 0.5 - 9.0 g / 100 ml, 1.0 -8.0 g/ 100 ml, or 1.5. - 7.5 g/ 100 ml.
  • the liquid nutritional composition can comprise eicosapentaenoic acid in an amount of 0.010 g- 0.200 g/100 ml, 0.025 0.175 g/100 ml, or 0.030 - 0.150 g/100 ml.
  • the liquid nutritional composition can comprise docosahexaenoic acid in an amount of 0.005-0.200g / 100ml, 0.01-0.175g/100ml, or 0.010-150g/100ml .
  • the ratio of the eicosapentaenoic acid to docosahexaenoic acid in the powder and the liquid formulation is from 5:1 to 1 :5, 2:1 to 1 :2, or 1.2:1 to 1 : 1.2.
  • the oil fraction in the powder and the liquid formulation can comprise at least one medium chain fatty acid (MCFA) or/and at least one mono -unsaturated fatty acid (MUFA).
  • MCFA medium chain fatty acid
  • MUFA mono -unsaturated fatty acid
  • the carbohydrates to be included into the composition can be digestible carbohydrates or indigestible carbohydrates.
  • Digestible carbohydrates are digested to deliver monosacharrides that are then absorbed in the small intestine, while indigestible carbohydrates are not digested and reach the colon.
  • the compositions of the invention can comprise digestible carbohydrates or/and indigestible carbohydrates.
  • the digestible carbohydrates can be sucrose, glucose, glucose syrup, com starch, or any combination thereof.
  • the indigestible carbohydrates can be resistant starches, pectins, mucilages, hemicellulose, cellulose, maltodextrin, inulin, oligofructose, and gums.
  • the nutritional composition can comprise further ingredients like acidulants, flavors, vitamins, minerals, emulsifiers, stabilizers, colorants or gums.
  • Acidulants to be used in the composition are food grade acidulants and can be citric acid, phosphoric acid, orthophosphoric acid, or any acidulant.
  • the nutritional composition can comprise at least one vitamin or preferably a vitamin mix.
  • the vitamins are preferably selected from the group consisting of vitamin A, vitamin D3, vitamin E, vitamin C, vitamin Bl , vitamin B2, vitamin B6, niacin, folic acid, vitamin B12, choline, panthotenic acid, or biotin or any combination thereof.
  • the composition comprises all vitamins listed above.
  • Emulgators to be used in the invention are food grade emulgators and can be lecithin, mono and diglycerides of food grade fatty acids, sugar esters of food grade fatty acids.
  • the nutritional composition can comprise at least one micronutrient, mineral or preferably a mineral or micronutrient mix.
  • the micronutrients are preferably selected from a group consisting of iron, copper, iodine, selenium, manganese, chromium, molybdenum, calcium, magnesium, potassium, sodium, and zinc, or any combination thereof. In a preferred embodiment all of these micronutrients are included into the nutritional composition of the invention. They can be added to the nutritional composition in the form of food grade salts. Kits
  • kits which differ from the liquid nutritional composition of the invention merely in that a liquid or dry composition containing whey TGF-beta is kept in a separate container.
  • the invention also relates to a kit comprising a first container comprising a further liquid composition the amino acids threonine, serine, and proline in free form and protein and essential fatty acids.
  • the kit also contains a second container comprising whey TGF-beta.
  • the kit might also contain a third or more further containers containing one or more additional components as described above in relation to the liquid nutritional composition if this is desired.
  • the first container can thus contain all components and exhibit all characteristics that have been described above in relation to the liquid nutritional composition.
  • the concentrations of the components of the first container will be adapted in a way that after mixing the content of the second container with the content of the first container the final concentrations will have the values that have been described for the liquid nutritional composition.
  • the second container will contain a composition comprising TGF-Beta in an amount that after mixing the content of the second container to the content of the first container TGF-Beta will be present in an amount that has been described above for the liquid nutritional composition.
  • TGF- Beta can be present in a liquid or dry form.
  • the composition in the first container might have a volume of 10-500 ml, 20-400 ml, 30-300 ml, 20-200 ml, or 50-100 ml.
  • the composition in the second container might have a volume of 1-50 ml, 2-40 ml, 3-30 ml, 2-20 ml, or 5-10 ml.
  • the ratio of the compositions in the first container to the container in the second container can be 10:1 , 50:1 , or 100:1.
  • the mixing of the contents of the first container and the second container might occur in the first container. In that case as size of the first container is chosen that allows the addition of the second container without any spill over.
  • a third container is contained in the kit that has a volume that allows the combination and mixing of the contents of the first and the second container. Mixing the components of the kit will result in a liquid nutritional composition reconstituted from the compositions contained in the two containers.
  • compositions including those contained in the kits can be used in the treatment of subjects.
  • the compositions are suitable for enterable feeding. Thus, they can be administered orally or via tube feeding.
  • the invention thus also relates to the nutritional composition of the invention for use in the treatment of IBD, for use in the treatment of a subject being in remission of IBD, or for use in delaying or preventing a relapse of IBD in a subject, or prolonging remission of IBD.
  • the composition of the invention is for use in the treatment of inflammatory bowel disease (IBD), prolonging remission of IBD, or in maintaining or improving the mucosa health status of an IBD patient.
  • IBD inflammatory bowel disease
  • IBD Crohn's Disease (CD) or ulcerative colitis (UC), CD is preferred.
  • CD Crohn's Disease
  • UC ulcerative colitis
  • composition of the invention can be administered for at least 10, 20, 24, 30, 40, 42, 50, or 60 weeks.
  • the composition of the invention can preferably be administered for between 10 and 60 weeks, between 20 and 50 weeks, between 15 and 30 weeks, or between 35 and 45 weeks.
  • composition of the invention can maintain or improve the mucosa health status of an IBD patient, as indicated by the maintenance of an endoscopic-proven healthy mucosa.
  • the maintenance of the endoscopic-proven healthy mucosa can be assessed by the simple endoscopic score - Crohn's Disease (SES-CD).
  • the improvement of the endoscopic-proven healthy mucosa can be indicated by a reduction in the mean SES-CD score from the onset of administration of the composition of the invention to a time point between 20 and 45 weeks, preferably 20 and 30 weeks, for example week 24, after the onset of administration of the composition of the invention (endoscopic improvement).
  • the maintenance of the endoscopic-proven healthy mucosa can be indicated by a maintenance of the endoscopic response, wherein an endoscopic response is indicated as effecting an SES-CD decrease of at least 3 points from the onset of administration of the composition of the invention to a time point between 20 and 45 weeks, preferably between 20 and 30 weeks, for example week 24, after the onset of administration of the composition of the invention.
  • the maintenance of the endoscopic-proven healthy mucosa can also be indicated by a maintenance of the clinical remission, wherein clinical remission is indicated as effecting a CDAI of less than 150 points at a time point of between20 and 45 weeks, preferably 20 and 30 weeks, for example week 24, after the onset of administration of the composition of the invention.
  • composition of the invention can prolong the time until endoscopic or clinical relapse.
  • composition of the invention can reduce the economic impact of CD as indicated by surgery, hospitalization and CD complication rates.
  • the composition of the invention can improve quality of life as indicated, for instance, by IBDQ, SF-36v2 and EQ-5 determined at a time point of between 20 and 45 weeks, preferably 20 and 30 weeks, for example week 24, after the onset of administration of the composition of the invention.
  • the composition of the invention can improve the composition and functionality of the gut microbiome.
  • composition of the invention can improve non-invasive biomarkers like CRP or fecal calprotectin.
  • composition of the invention is also characterized in that the administration of said composition is efficacious with respect to the medical indications indicated above for at least 10, 20, 24, 30, 40, 42, 50, or 60 weeks or at a time point selected from any time point between 10 and 60 weeks, between 10 and 50 weeks, between 20 and 50 weeks, between 20 and 30 weeks, or between 40 and 50 weeks after the onset of administration of the composition.
  • the invention also relates to a method comprising administrating the liquid nutritional composition of the invention or the reconstituted powder nutritional composition of the invention, or the liquid nutritional composition reconstituted from the kit of the invention to a subject having IBD.
  • the nutritional composition of the invention can be combined with standard treatments common in the treatment of IBD. These standard treatments comprise surgery, antibiotics, immunosuppressants and anti-inflammatory drugs.
  • Immuno -suppressants can be selected from the group consisting of prednisone, TNF or TNFalpha inhibitors (e.g. infliximab, adalimumab), azathioprine (Imuran), methotrexate, and 6-mercaptopurine.
  • a preferred anti-inflammatory drug is mesalamine (USAN) or 5-aminosalicylic acid (5-amino-2-hydroxybenzoic acid, 5-ASA).
  • the composition is administered in combination with at least one TNF inhibitor or TNF inhibitor therapy.
  • the at least one TNF inhibitor is a TNF alpha inhibitor.
  • the at least one TNF alpha inhibitor is infliximab or adalimumab and most preferred the TNF alpha inhibitors are a combination of infliximab and adalimumab.
  • Preferred is the administration of any of the above cited immuno-suppressants and antiinflammatory drugs in combination with the nutritional composition of the invention. The combination results in a cooperative effect of the administered compounds.
  • the invention also relates to the nutritional composition of the invention for use in the treatment of IBD, for use in the treatment of a subject being in remission of IBD, or for use in preventing or delaying a relapse of IBD in a subject wherein the nutritional compositions is to be administered in combination with medicament effective against IBD, said medicament preferably being an immunosuppressant or 5-aminosalicylic acid (5-ASA).
  • This subject could be a subject that has undergone surgery or will undergo surgery.
  • the administration of the nutritional composition can occur before, during or after the administration of the above cited drugs.
  • the invention also relates to a method comprising administrating the liquid nutritional composition of the invention or the reconstituted powder nutritional composition of the invention, or the liquid nutritional composition reconstituted from the kit of the invention and a medicament effective against IBD, said medicament preferably being an immunosuppressant or 5-aminosalicylic acid (5-ASA) to a subject having IBD or a relapse of IBD thereby treating a subject suffering from IBD or to a subject being in remission of IBD and thereby delaying or preventing a relapse of IBD.
  • a medicament effective against IBD said medicament preferably being an immunosuppressant or 5-aminosalicylic acid (5-ASA) to a subject having IBD or a relapse of IBD thereby treating a subject suffering from IBD or to a subject being in remission of IBD and thereby delaying or preventing a relapse of IBD.
  • 5-ASA 5-aminosalicylic acid
  • the invention also relates to a method comprising administrating the liquid nutritional composition of the invention or the reconstituted powder nutritional composition of the invention, or the liquid nutritional composition reconstituted from the kit of the invention to a subject before undergoing surgery or after having undergone surgery with the aim of treating IBD and thereby treating IBD.
  • composition is an exemplary powder nutritional composition.
  • Example 2 Liquid nutritional composition
  • composition is an exemplary liquid nutritional composition.
  • CDAI score 0-300 inclusive a known history of symptomatic CD confirmed by endoscopy or radiology, clinical remission or mild- to moderate disease (CDAI score 0-300 inclusive), active endoscopic disease (SES-CD score > 4) documented during the study screening phase, able to consume oral nutrition for up to 24 weeks and optionally initiation of induction infliximab or adalimumab therapy at least 12 weeks prior to randomization(maximum 20 weeks).
  • composition to be tested and regimen The composition is a nutritionally-based, anti-inflammatory therapy with a high protein content consisting of whey and casein protein (14 g per serving), whey-TGF (10-40 meg TGF-beta per serving), plus the free amino acids: threonine in free form (3.3 g per serving), serine in free form (2.75 g per serving) and proline in free form (2.75 g per serving).
  • the placebo is an appearance and volume -matched formulation consisting of maltodextrin and skimmed milk powder, which will be used in the control group.
  • composition is provided in a powder formulation that is reconstituted with 120 ml of water, which yield to a 135 mL formulation. Patients take 2 times 135 ml servings orally between meals each day for 24 weeks.
  • the study is a randomized placebo-controlled trial to assess the impact of a nutritional intervention in the maintenance and improvement of the intestinal mucosa health status of CD's patients.
  • the shift in the patient's nutritional status is hypothesized to be achieved through the administration of the medical food.
  • the assessment of the effectiveness of the composition is based on the results of colonoscopy, biopsy, questionnaires and other parameters as explained below.
  • Colonoscopy is performed during the study screening phase and at week 24 after initiating the treatment with the medical food. Colonoscopy includes SES-CD scoring.
  • biopsies are taken and assessed for the presence of inflammation, e.g. using the global histologic disease activity score.
  • questionnaires are to be completed by the participants of the study (for instance, SF- 36v2, EQ-5D, WPAI-CD) and other parameters determined (fecal calprotectin, c-reactive protein, fecal microbiome).
  • the nutritional status of patients are recorded (weight gain, albumin & prealbumin levels, serum levels of AAs amd micronutrients, BMI, % body fat)
  • a significant improvement or maintenance of the values of the parameters compared to the values determined in the control group is indicative for the effectiveness of the administration of the composition.
  • Gastrointest Endosc 2004;60:505- 12. evaluates 4 endoscopic variables (ulcer size, proportion of the surface area that is ulcerated, proportion of the surface area affected, and stenosis) by scoring each variable on a scale from 0 to 3 where higher scores indicate more severe disease, in five colonic segments (ileum, right colon, transverse colon, left colon, and rectum).
  • the score for each endoscopic variable is the sum of the values obtained for each segment.
  • the SES-CD Total is the sum of the 4 endoscopic variable scores.
  • Endoscopic Improvement Reduction in the mean SES-CD score from baseline to Week 24.
  • Endoscopic Response SES-CD decrease of at least 3 points
  • CDAI Crohn's disease activity index
  • the Crohn's disease activity index (CDAI) score provides a measurement of the active status of Crohn's disease in a patient over a given week.
  • the CDAI will be calculated combining subject, Investigator and laboratory entries.
  • Components of the CDAI are the following:
  • CDAI Crohn's Disease Activity Index
  • CDAI decreased by at least 100 points from the randomization visit
  • the Global Histologic Disease Activity Score assesses the extent and severity of histologic inflammation in colonic or ileal biopsy samples in CD. 7 characteristic factors are taken into account including epithelial and architecture changes, inflammatory cell infiltrates, erosions or ulcers, granulomas, and an adjustment for the number of biopsy samples affected (D'Haens GR, Geboes K, Peeters M, et al. Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum. Gastroenterology 1998; 114:262-7; Geboes K, Dalle I. Influence of treatment on morphological features of mucosal inflammation. Gut 2002;50:iii37-iii42.).
  • the total score is the sum of all individual
  • Histopathologic Remission GHAS total ⁇ 4 Histopathologic Improvement: GHAS decrease.
  • the SF-36 questionnaire (Version 2; SF-36v2;) is a validated generic health-related quality of life instrument which consists of 36 questions aggregated into 8 domains (Smith JJ, Netuveli G, Sleight SP, et al. Development of a social morbidity score in patients with chronic ulcerative colitis as a potential guide to treatment. Colorectal Dis 2012;14:e250-7). These domains are further summarised into two components, a physical component summary (PCS) scale and a mental component summary (MCS) scale. Each scale ranges from 0 to 100 with higher scores indicating better functional status.
  • PCS physical component summary
  • MCS mental component summary
  • the EQ-5D was developed as a cardinal index of health, which takes into account physical, mental and social functions, and is simple to complete (Stark RG, Reitmeir P, Leidl R, et al. Validity, reliability, and responsiveness of the EQ-5D in inflammatory bowel disease in Germany. Inflamm Bowel Dis 2010;16:42-51).
  • the questionnaire contains 5 questions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression. The 5 questions are summarized into one global score, the EQ- 5D single index. Higher scores are associated with more impairment.
  • the instrument generates a single numeric index of health status which ranges from 0 to 100 measured on a visual analogue scale, with 0 and 100 indicating worst and best imaginable health state respectively.
  • the EQ-5D questionnaire will be self-administered by the study subjects.
  • the WPAI-CD (Reilly MC, Gerlier L, Brabant Y, et al. Validity, reliability, and responsiveness of the work productivity and activity impairment questionnaire in Crohn's disease. Clin Ther 2008;30:393-404; Feagan BG, Reilly MC, Gerlier L, et al. Clinical trial: the effects of certolizumab pegol therapy on work productivity in patients with moderate-to-severe Crohn's disease in the PRECiSE 2 study. Aliment Pharmacol Ther 2010;31 :1276-85) consists of 6 questions that evaluate absenteeism (work time missed), presenteeism (reduced work productivity), overall work impairment, and activity impairment. The WPAI- CD questionnaire will be self-administered by the study subjects.
  • Stool samples will be obtained at day 0, at week 12 and at week 24 for the measurement of fecal calprotectin levels.
  • C-reactive protein will be assessed at day 0, at week 12 and at week 24.
  • C-reactive protein belongs to the pentraxin family of proteins, is made exclusively in the liver and is secreted in increased amounts within 6 hours of an acute inflammatory stimulus.
  • the plasma level can double at least every 8 hours, reaching a peak after about 50 hours. After effective treatment or removal of the inflammatory stimulus, levels can fall almost as rapidly as the 5-7 -hour plasma half-life of labelled exogenous CRP.
  • the only condition that interferes with the "normal" CRP response is severe hepatocellular impairment.
  • CD is one of the most common conditions associated with major elevations of CRP levels (Vermeire S, Van Assche G, Rutgeerts P. C-reactive protein as a marker for inflammatory bowel disease. Inflamm Bowel Dis 2004;10:661-5). While an elevated CRP value is not specific for any condition, it is a sensitive index of ongoing inflammation, and thus provides a valuable adjunct to a careful clinical assessment. Once a diagnosis has been established, CRP may be used to monitor the subject's response to therapy. Serial CRP measurements are important adjuncts in clinical practice, as CRP levels are not affected by drug therapy or thermoregulatory factors. In CD, CRP levels correspond well to disease activity and treatment efficacy (Vermeire S, Van Assche G, Rutgeerts P. C-reactive protein as a marker for inflammatory bowel disease. Inflamm Bowel Dis 2004;10:661 -5).

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Abstract

L'invention concerne des compositions et des méthodes qui sont utiles dans le traitement de patients atteints d'une maladie inflammatoire de l'intestin (IBD). Les compositions et procédés selon l'invention sont appropriés pour prévenir ou retarder une rechute chez des patients atteints d'une maladie intestinale inflammatoire.
PCT/EP2016/051275 2015-01-23 2016-01-22 Composition nutritionnelle utile dans le traitement de patients atteints d'une ibd WO2016116580A1 (fr)

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CN201680004920.8A CN107106653A (zh) 2015-01-23 2016-01-22 可用于治疗ibd患者的营养组合物
JP2017536953A JP2018504405A (ja) 2015-01-23 2016-01-22 Ｉｂｄ患者の治療に有用な栄養組成物
BR112017014107A BR112017014107A2 (pt) 2015-01-23 2016-01-22 composição nutricional útil no tratamento de pacientes com ibd
AU2016208455A AU2016208455A1 (en) 2015-01-23 2016-01-22 Nutritional composition useful in the treatment of IBD patients
EP16701315.0A EP3247343A1 (fr) 2015-01-23 2016-01-22 Composition nutritionnelle utile dans le traitement de patients atteints d'une ibd
CA2973433A CA2973433A1 (fr) 2015-01-23 2016-01-22 Composition nutritionnelle utile dans le traitement de patients atteints d'une ibd
US15/544,088 US10137108B2 (en) 2015-01-23 2016-01-22 Nutritional composition useful in the treatment of IBD patients
HK18105261.1A HK1245658A1 (zh) 2015-01-23 2018-04-23 可用於治療ibd患者的營養組合物

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US10201513B2 (en) 2016-12-19 2019-02-12 Axcella Health Inc. Amino acid compositions and methods for the treatment of liver diseases
US10596136B2 (en) 2018-06-20 2020-03-24 Axcella Health Inc. Compositions and methods for the treatment of fat infiltration in muscle
JP2020513014A (ja) * 2017-04-07 2020-04-30 チルドレンズ ホスピタル メディカル センター ２’−フコシルラクトース化合物による炎症性腸疾患の治療
US10660870B2 (en) 2017-08-14 2020-05-26 Axcella Health Inc. Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting
WO2022002862A1 (fr) * 2020-06-30 2022-01-06 B. Braun Melsungen Ag Préparation pour nutrition entérale
EP4295843A1 (fr) * 2022-06-23 2023-12-27 Professional Dietetics S.p.A. Compositions comprenant des acides aminés destinées à être utilisées dans la prévention et/ou le traitement de maladies intestinales

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WO2018220588A1 (fr) 2017-05-31 2018-12-06 Nestec S.A. Procédés d'évaluation de la cicatrisation des muqueuses chez des patients atteints de la maladie de crohn
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Cited By (15)

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Publication number Priority date Publication date Assignee Title
US10238617B2 (en) 2016-12-19 2019-03-26 Axcella Health Inc. Amino acid compositions and methods for the treatment of liver diseases
US10471034B2 (en) 2016-12-19 2019-11-12 Axcella Health Inc. Amino acid compositions and methods for the treatment of liver diseases
US10201513B2 (en) 2016-12-19 2019-02-12 Axcella Health Inc. Amino acid compositions and methods for the treatment of liver diseases
US11602511B2 (en) 2016-12-19 2023-03-14 Axcella Health Inc. Amino acid compositions and methods for the treatment of liver diseases
US11129804B2 (en) 2016-12-19 2021-09-28 Axcella Health Inc. Amino acid compositions and methods for the treatment of liver diseases
JP2020513014A (ja) * 2017-04-07 2020-04-30 チルドレンズ ホスピタル メディカル センター ２’−フコシルラクトース化合物による炎症性腸疾患の治療
US11571404B2 (en) 2017-08-14 2023-02-07 Axcella Health Inc. Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting
US10660870B2 (en) 2017-08-14 2020-05-26 Axcella Health Inc. Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting
US10682325B2 (en) 2017-08-14 2020-06-16 Axcella Health Inc. Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting
US10596136B2 (en) 2018-06-20 2020-03-24 Axcella Health Inc. Compositions and methods for the treatment of fat infiltration in muscle
US10973793B2 (en) 2018-06-20 2021-04-13 Axcella Health Inc. Compositions and methods for the treatment of fat infiltration in muscle
US11833127B2 (en) 2018-06-20 2023-12-05 Axcella Health Inc. Compositions and methods for the treatment of fat infiltration in muscle
WO2022002862A1 (fr) * 2020-06-30 2022-01-06 B. Braun Melsungen Ag Préparation pour nutrition entérale
EP4295843A1 (fr) * 2022-06-23 2023-12-27 Professional Dietetics S.p.A. Compositions comprenant des acides aminés destinées à être utilisées dans la prévention et/ou le traitement de maladies intestinales
WO2023248035A1 (fr) * 2022-06-23 2023-12-28 Professional Dietetics S.P.A. Compositions comprenant des acides aminés destinées à être utilisées dans la prévention et/ou le traitement de maladies intestinales

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