WO2016103504A1 - Biocapteur - Google Patents

Biocapteur Download PDF

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Publication number
WO2016103504A1
WO2016103504A1 PCT/JP2014/084670 JP2014084670W WO2016103504A1 WO 2016103504 A1 WO2016103504 A1 WO 2016103504A1 JP 2014084670 W JP2014084670 W JP 2014084670W WO 2016103504 A1 WO2016103504 A1 WO 2016103504A1
Authority
WO
WIPO (PCT)
Prior art keywords
muscle
light
biosensor
receiving unit
unit
Prior art date
Application number
PCT/JP2014/084670
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English (en)
Japanese (ja)
Inventor
裕 松井
悠史 居鶴
Original Assignee
パイオニア株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by パイオニア株式会社 filed Critical パイオニア株式会社
Priority to JP2016565842A priority Critical patent/JPWO2016103504A1/ja
Priority to PCT/JP2014/084670 priority patent/WO2016103504A1/fr
Publication of WO2016103504A1 publication Critical patent/WO2016103504A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/107—Measuring physical dimensions, e.g. size of the entire body or parts thereof

Definitions

  • the present invention relates to a biosensor, and more particularly, to a technical field of a biosensor that measures a state of a living body using optical technology.
  • a device that is fixed to the subject's arm by a wearing band, has a push member that changes according to the contraction state of the muscle, and outputs a detection signal corresponding to the displacement of the push member. (See Patent Document 2).
  • JP 2001-70289 A Japanese Patent Laid-Open No. 5-068675
  • Patent Document 1 monitors the oxygen saturation level that is lowered (ie, changes appear) due to muscle contraction for a certain period of time, and therefore cannot detect instantaneous muscle contraction. There is a point.
  • Patent Document 2 since the wearing band is wound around the subject's arm, for example, contraction combining the movement of the main muscle and the movement of the antagonistic muscle is detected, and the contraction of each muscle can be detected. There is a technical problem that cannot be done.
  • the electromyograph that measures the body surface potential requires labor and attention when attaching the sensor, and in addition, a technical problem that a highly accurate detection circuit for detecting weak potential is necessary. There is.
  • the present invention has been made in view of the above-mentioned problems, for example, and an object of the present invention is to provide a biosensor that can detect the movement of individual muscles and is simple to mount and configure.
  • the biosensor of the present invention is a biosensor attached to a living body as a subject, and a light emitting unit that emits light to the living body, and at least one part of the living body
  • a light receiving unit that receives return light from the muscle of the device, and an output unit that outputs information related to the deformation of the muscle of the one part based on a detection signal from the light receiving unit according to the received return light, Is provided.
  • the biosensor according to the embodiment is a biosensor attached to a living body as a subject, and receives a return light from a light emitting unit that irradiates light to the living body and muscles of at least one part of the living body. And an output unit that outputs information related to the deformation of the muscle of one part based on a detection signal from the light receiving unit corresponding to the received return light.
  • the biosensor is attached to a living body when it is used.
  • the biological sensor may be attached to the living body by a dedicated attachment member such as a band, or may be attached to the living body by, for example, a medical paper tape.
  • the light emitting part emits light (red light to infrared light) having a wavelength of, for example, 660 ⁇ m to 940 ⁇ m.
  • the wavelength of the light emitted from the light emitting unit is not limited to the above-described wavelength, and may be appropriately set according to the measurement target, for example.
  • the light receiving unit receives at least return light from the muscle of one part of the living body.
  • an output unit including a memory, a processor, and the like outputs information related to the deformation of the muscle of one part based on the detection signal from the light receiving unit.
  • the muscle of one part contracts, the physical distance between the light emitting unit and the light receiving unit decreases and the muscle pressure increases as compared to when the muscle is stretched (when relaxed). .
  • the amount of return light received by the light receiving unit increases compared to when the muscle expands (that is, the signal level of the detection signal increases).
  • the output unit outputs, for example, information indicating the signal level of the detection signal as information related to the deformation of the muscle of one part.
  • information on the deformation of the muscle is output based on the return light from the muscle at one site, so that an instantaneous change in the muscle at one site can be detected. It is.
  • the detection signal from the light receiving unit is closest to the biological sensor. The effect of muscle deformation is dominant. That is, according to the biosensor, only the deformation of the muscle of one part can be detected.
  • the biosensor optically detects muscle deformation
  • the configuration can be simplified and handling can be facilitated compared to an electromyograph that measures a weak potential on the body surface. it can.
  • the output unit determines that the increase in the signal level of the detection signal is contraction of the muscle of one part.
  • the light emitting unit and the light receiving unit are disposed on a flexible member.
  • the distance between the light emitting unit and the light receiving unit on the member can be kept constant, the measurement result by the biosensor can be given reproducibility and the biosensor can be easily applied to the living body. Can be attached to.
  • the biological sensor further includes attenuation means for attenuating a signal component having a period longer than a predetermined period included in the detection signal.
  • the detection signal includes the influence of physiological responses such as changes in cardiac output.
  • the influence of the physiological response included in the detection signal is longer than the fluctuation period of the detection signal due to the change in the muscle.
  • the signal component having a period longer than the predetermined period included in the detection signal is attenuated by the attenuation means. Therefore, according to this aspect, it is possible to suitably detect the deformation of the muscle at one site.
  • FIG. 1 is a block diagram illustrating an outline of the biosensor according to the embodiment.
  • the biosensor 100 includes a light emitting unit 11, a light receiving unit 12, a calculation unit 13, and a display unit 14.
  • the light emitting unit 11 includes a light emitting element such as an LED (Light Emitting Diode).
  • the wavelength of the light emitted from the light emitting unit 11 may be appropriately set according to the measurement target, for example.
  • the light receiving unit 12 includes a light receiving element such as PD (Photodioe).
  • the light emitting unit 12 receives at least the return light from the measurement target muscle of the living body as the subject.
  • return light typically means light scattered or reflected by a living body.
  • the light receiving unit 12 outputs a biological signal as “a detection signal corresponding to the received return light” according to the present invention.
  • the calculation unit 13 includes a bandpass filter 131 and a normalization unit 132 as shown in FIG. Details of the operation of the calculation unit 13 will be described later.
  • FIG. 2 is a diagram for explaining the measurement principle of the biosensor according to the embodiment.
  • each of the light emitting unit 11 and the light receiving unit 12 of the biological sensor 100 is attached to a site including the muscle to be measured of the subject.
  • Each of the light emitting unit 11 and the light receiving unit 12 may not be attached to the subject's skin directly or via a gel or cream.
  • the movement of the muscle to be measured such as clothes that are in close contact with the skin, appears. If it is such clothes, it may be worn from above the clothes.
  • each of the light emitting unit 11 and the light receiving unit 12 is preferably disposed on a flexible member (in FIG. 2B, the flexible member is illustrated for convenience of explanation. Not shown). However, each of the light emitting unit 11 and the light receiving unit 12 may not be disposed on the flexible member.
  • the “flexible member” according to the embodiment is an example of the “flexible member” according to the present invention.
  • the myosin filament draws the actin filament into the close center, and the myosin filament and the actin filament overlap each other deeply. It changes into a shape (see FIG. 2B).
  • the amount of light detected by the light receiving unit 12 that is, the signal level of the output biological signal
  • the change in the muscle to be measured have a correlation.
  • the leg muscles of the subject periodically repeat contraction and relaxation.
  • the biological signal output from the light receiving unit 12 has a period synchronized with pedaling, for example, as shown in FIG.
  • the biological signal includes the influence of a physiological reaction such as a change in cardiac output. Specifically, as shown in FIG. 4A, due to a physiological response, the entire biological signal fluctuates up and down at a relatively long period. Note that the biological signal shown in FIG. 4 shows fluctuation over about 10 minutes.
  • the component due to the physiological reaction included in the biological signal is attenuated by the bandpass filter 131 (see FIG. 1B) of the calculation unit 13.
  • the signal output from the bandpass filter 131 is as shown in FIG.
  • the filtered signal output from the bandpass filter 131 is normalized by the normalization unit 132 (see FIG. 1B). Specifically, the normalization unit 132 normalizes the signal after filtering by setting the maximum value of the signal amplitude of the filtered signal as the maximum contraction state of the muscle and the minimum value of the signal amplitude as the non-contraction state of the muscle.
  • the normalization unit 132 sets the maximum value of the normalized signal to 100% muscle contraction rate and the minimum value of the normalized signal to 0% muscle contraction rate.
  • the “information indicating the time variation of the contraction rate of the muscle” according to the embodiment is an example of “information relating to the deformation of the muscle of one part” according to the present invention.
  • crank angle of the bicycle that the subject is pedaling is detected by the crank angle sensor 20 (for example, a pedaling monitor).
  • the display unit 14 of the biometric sensor 100 uses the crank angle detected by the crank angle sensor 20, and for example, corresponds to the crank angle and information indicating time variation of the muscle contraction rate output from the calculation unit 13. Attached and displayed (see FIG. 5).
  • the biosensor 100 is not limited to the pair of light emitting units 11 and the light receiving unit 12, and may include a plurality of pairs of light emitting units and light receiving units. If comprised in this way, for example, used for the pedaling movement of a bicycle, the rectus femoris muscle (thigh front part), the femoral triceps muscle (hamstrings outer side), the gluteus dorsi muscles (buttocks), semi-tendon-like muscles (hamstring inner side ), The transition of contraction rate of each of a plurality of muscles such as the anterior tibial muscle (front calf) and the gastrocnemius (back calf) can be detected (see FIG. 6).
  • the electromyograph detects an action potential resulting from a command to contract the muscle from the brain.
  • the biological sensor 100 optically detects a change in muscle as described above.
  • the biosensor 100 detects a result of a change in muscle.
  • the electromyograph and the biosensor 100 have different measurement principles, but as shown in FIG. 7, the measurement results for each muscle are very similar.
  • the measurement result by the biosensor 100 is appropriate and has the same measurement accuracy as the electromyograph. That is, the biosensor 100 can measure an instantaneous muscle change with high accuracy for each muscle, like an electromyograph.
  • the electromyograph measures the action potential of muscle, it can also measure muscle contraction that does not involve muscle deformation, such as isometric contraction.
  • the biosensor 100 measures muscle contraction from a change in the amount of received light caused by a change in muscle, it cannot measure muscle contraction that does not involve muscle deformation.
  • the biosensor 100 can measure changes in the muscle if the light emitting unit 11 and the light receiving unit 12 can be physically fixed to a region including the muscle to be measured, and the handling thereof is very easy. is there.
  • the biological sensor 100 only needs to be able to detect a signal at a speed at which the subject operates (for example, 10 Hz or less), so that, for example, the circuit configuration and the like can be simplified and the size can be reduced.
  • the biological sensor 100 can preferably measure the state of the muscle in a field where the muscle is actively moved, such as a sports field.
  • bicycle pedaling is taken as an example.
  • the biological sensor 100 is a relatively simple periodic motion such as jogging or running, the biological sensor 100 can perform measurement as shown in FIGS. The result can be displayed.
  • the “calculation unit 13” and the “bandpass filter 131” according to the embodiment are examples of the “output unit” and the “attenuating unit” according to the present invention, respectively.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

La présente invention concerne un biocapteur (100) qui est porté sur un corps vivant en tant que sujet du test, lors de son utilisation. Le biocapteur est pourvu d'une unité électroluminescente (11) permettant d'exposer ledit corps vivant à de la lumière, d'une unité (12) de réception de lumière permettant de recevoir la lumière réfléchie à partir d'un muscle dans au moins un emplacement du corps vivant, et d'une unité de sortie (13) permettant de délivrer des informations relatives à la déformation du muscle dans un emplacement sur la base d'un signal de détection en provenance de l'unité de réception de lumière en correspondance avec la lumière réfléchie reçue.
PCT/JP2014/084670 2014-12-26 2014-12-26 Biocapteur WO2016103504A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2016565842A JPWO2016103504A1 (ja) 2014-12-26 2014-12-26 生体センサ
PCT/JP2014/084670 WO2016103504A1 (fr) 2014-12-26 2014-12-26 Biocapteur

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2014/084670 WO2016103504A1 (fr) 2014-12-26 2014-12-26 Biocapteur

Publications (1)

Publication Number Publication Date
WO2016103504A1 true WO2016103504A1 (fr) 2016-06-30

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JP (1) JPWO2016103504A1 (fr)
WO (1) WO2016103504A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0568675A (ja) * 1991-05-02 1993-03-23 Yamaha Corp 生体測定装置
JP2010029633A (ja) * 2008-06-30 2010-02-12 Tokai Rubber Ind Ltd 筋肉動の検出方法および筋肉動検出装置
JP2014226417A (ja) * 2013-05-24 2014-12-08 パナソニック株式会社 運動状態測定装置

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0568675A (ja) * 1991-05-02 1993-03-23 Yamaha Corp 生体測定装置
JP2010029633A (ja) * 2008-06-30 2010-02-12 Tokai Rubber Ind Ltd 筋肉動の検出方法および筋肉動検出装置
JP2014226417A (ja) * 2013-05-24 2014-12-08 パナソニック株式会社 運動状態測定装置

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