WO2016059602A3 - Méthodes de traitement du cancer et compositions associées - Google Patents
Méthodes de traitement du cancer et compositions associées Download PDFInfo
- Publication number
- WO2016059602A3 WO2016059602A3 PCT/IB2015/057947 IB2015057947W WO2016059602A3 WO 2016059602 A3 WO2016059602 A3 WO 2016059602A3 IB 2015057947 W IB2015057947 W IB 2015057947W WO 2016059602 A3 WO2016059602 A3 WO 2016059602A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- antigen binding
- binding proteins
- combination therapy
- treat cancer
- her3
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
La présente invention concerne des protéines de liaison à un antigène, telles que des anticorps, qui se lient à HER3, des polynucléotides codant pour ces protéines de liaison à un antigène, des compositions pharmaceutiques comprenant lesdites protéines de liaison à un antigène, et des procédés de fabrication. La présente invention porte en outre sur l'utilisation de ces protéines de liaison à un antigène dans le traitement ou la prophylaxie de maladies associées au cancer du sein, des ovaires, de la prostate, de la vessie, du pancréas, et de l'estomac, au mélanome et à d'autres types de cancer surexprimant HER3.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462064559P | 2014-10-16 | 2014-10-16 | |
US62/064,559 | 2014-10-16 | ||
US201562121639P | 2015-02-27 | 2015-02-27 | |
US62/121,639 | 2015-02-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2016059602A2 WO2016059602A2 (fr) | 2016-04-21 |
WO2016059602A3 true WO2016059602A3 (fr) | 2016-06-09 |
Family
ID=54477033
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2015/057947 WO2016059602A2 (fr) | 2014-10-16 | 2015-10-15 | Méthodes de traitement du cancer et compositions associées |
Country Status (1)
Country | Link |
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WO (1) | WO2016059602A2 (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
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KR20210060670A (ko) | 2008-12-09 | 2021-05-26 | 제넨테크, 인크. | 항-pd-l1 항체 및 t 세포 기능을 향상시키기 위한 그의 용도 |
BR112013004266A8 (pt) | 2010-08-23 | 2018-01-02 | Univ Texas | anticorpos anti-ox40 e métodos de uso dos mesmos. |
MX2016010082A (es) | 2014-02-04 | 2016-10-07 | Pfizer | Combinacion de un antagonista de proteina de muerte programada 1 (pd-1) y un inhibidor del receptor del factor de crecimiento endotelial vascular (vegfr) para tratar cancer. |
IL278423B2 (en) | 2015-02-26 | 2024-04-01 | Merck Patent Gmbh | Fidi-1 / Fidi-AL1 inhibitors for cancer treatment |
SG11201707383PA (en) | 2015-03-13 | 2017-10-30 | Cytomx Therapeutics Inc | Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof |
KR20180015650A (ko) | 2015-05-07 | 2018-02-13 | 아게누스 인코포레이티드 | 항-ox40 항체 및 이의 사용 방법 |
WO2016205277A1 (fr) | 2015-06-16 | 2016-12-22 | Merck Patent Gmbh | Polythérapies faisant intervenir un antagoniste de pd-l1 |
CN108368170B (zh) | 2015-07-13 | 2022-04-15 | 西托姆克斯治疗公司 | 抗pd-1抗体、可活化抗pd-1抗体及其使用方法 |
KR20180083944A (ko) | 2015-12-02 | 2018-07-23 | 아게누스 인코포레이티드 | 항체 및 이의 사용 방법 |
US11542332B2 (en) | 2016-03-26 | 2023-01-03 | Bioatla, Inc. | Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof |
US11596699B2 (en) | 2016-04-29 | 2023-03-07 | CureVac SE | RNA encoding an antibody |
JP6729926B2 (ja) * | 2016-05-12 | 2020-07-29 | 国立大学法人神戸大学 | ErbB3活性化に伴うシグナルの伝達抑制物質及びそのスクリーニング方法 |
AU2017339856A1 (en) | 2016-10-06 | 2019-05-23 | Merck Patent Gmbh | Dosing regimen of avelumab for the treatment of cancer |
AU2017359467A1 (en) | 2016-11-09 | 2019-05-02 | Agenus Inc. | Anti-OX40 antibodies, anti-GITR antibodies, and methods of use thereof |
US11040027B2 (en) | 2017-01-17 | 2021-06-22 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
US10311977B2 (en) | 2017-02-16 | 2019-06-04 | Huff & Enterprises, LLC | Proactive disease state management system |
JP2020522486A (ja) | 2017-06-01 | 2020-07-30 | サイトメックス セラピューティクス インコーポレイテッド | 活性化可能抗pdl1抗体、およびその使用方法 |
WO2018225034A1 (fr) * | 2017-06-09 | 2018-12-13 | Glaxosmithkline Intellectual Property Development Limited | Polythérapie avec un agoniste icos et un agoniste ox40 pour traiter le cancer |
AU2020284288A1 (en) * | 2019-05-27 | 2022-01-20 | Promis Neurosciences Inc. | Conformation-specific epitopes in tau, antibodies thereto and methods related thereof |
GB201913079D0 (en) * | 2019-09-11 | 2019-10-23 | Hummingbird Bioscience Holdings Pte Ltd | Treatment and prevention of cancer using her3 antigen-binding molecules |
US20230029157A1 (en) * | 2019-11-26 | 2023-01-26 | The Regents Of The University Of California | Combination therapy for head and neck cancer |
MX2022008412A (es) | 2020-01-07 | 2022-08-08 | Univ Texas | Variantes de enzima que agotan metiltioadenosina/adenosina mejorada humana para terapia de cancer. |
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EP2161336A1 (fr) * | 2005-05-09 | 2010-03-10 | ONO Pharmaceutical Co., Ltd. | Anticorps monoclonaux humains pour mort programmée 1 (PD-1) et procédés de traitement du cancer à l'aide d'anticorps anti-PD-1 seuls ou combinés à d'autres formulations immunothérapeutiques |
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WO2012031198A2 (fr) * | 2010-09-03 | 2012-03-08 | Glaxo Group Limited | Nouvelles protéines de liaison à un antigène |
WO2013071058A1 (fr) * | 2011-11-09 | 2013-05-16 | The Uab Research Foundation | Anticorps her3 et utilisations de ceux-ci |
WO2014083178A1 (fr) * | 2012-11-30 | 2014-06-05 | F. Hoffmann-La Roche Ag | Identification de patients ayant besoin d'une cothérapie par un inhibiteur de pd-l1 |
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Publication number | Priority date | Publication date | Assignee | Title |
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EP2161336A1 (fr) * | 2005-05-09 | 2010-03-10 | ONO Pharmaceutical Co., Ltd. | Anticorps monoclonaux humains pour mort programmée 1 (PD-1) et procédés de traitement du cancer à l'aide d'anticorps anti-PD-1 seuls ou combinés à d'autres formulations immunothérapeutiques |
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Non-Patent Citations (3)
Title |
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C. MIRSCHBERGER ET AL: "RG7116, a Therapeutic Antibody That Binds the Inactive HER3 Receptor and Is Optimized for Immune Effector Activation", CANCER RESEARCH, vol. 73, no. 16, 15 August 2013 (2013-08-15), US, pages 5183 - 5194, XP055239599, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-13-0099 * |
J. B. FITZGERALD ET AL: "MM-141, an IGF-IR- and ErbB3-Directed Bispecific Antibody, Overcomes Network Adaptations That Limit Activity of IGF-IR Inhibitors", MOLECULAR CANCER THERAPEUTICS, vol. 13, no. 2, 1 February 2014 (2014-02-01), US, pages 410 - 425, XP055218661, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-13-0255 * |
N. JIANG ET AL: "Combination of Anti-HER3 Antibody MM-121/SAR256212 and Cetuximab Inhibits Tumor Growth in Preclinical Models of Head and Neck Squamous Cell Carcinoma", MOLECULAR CANCER THERAPEUTICS, vol. 13, no. 7, 18 April 2014 (2014-04-18), US, pages 1826 - 1836, XP055239604, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-13-1093 * |
Also Published As
Publication number | Publication date |
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WO2016059602A2 (fr) | 2016-04-21 |
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