WO2015159620A1 - Système d'automatisation d'inspection d'échantillon, module de contrôle et procédé de contrôle d'échantillon - Google Patents

Système d'automatisation d'inspection d'échantillon, module de contrôle et procédé de contrôle d'échantillon Download PDF

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Publication number
WO2015159620A1
WO2015159620A1 PCT/JP2015/057573 JP2015057573W WO2015159620A1 WO 2015159620 A1 WO2015159620 A1 WO 2015159620A1 JP 2015057573 W JP2015057573 W JP 2015057573W WO 2015159620 A1 WO2015159620 A1 WO 2015159620A1
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Prior art keywords
container
sample
unit
automation system
test automation
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PCT/JP2015/057573
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English (en)
Japanese (ja)
Inventor
孝浩 佐々木
巌 鈴木
元 末成
樹生 中川
佳奈子 江崎
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株式会社日立ハイテクノロジーズ
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Priority to JP2016513672A priority Critical patent/JP6516727B2/ja
Publication of WO2015159620A1 publication Critical patent/WO2015159620A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G01N2035/00742—Type of codes
    • G01N2035/00752—Type of codes bar codes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0474—Details of actuating means for conveyors or pipettes
    • G01N2035/0491—Position sensing, encoding; closed-loop control
    • G01N2035/0493—Locating samples; identifying different tube sizes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N2035/1025—Fluid level sensing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/22—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance

Definitions

  • the present invention relates to a specimen test automation system and a check module for automatically checking the state of a biological sample such as blood collected in a container and a reagent used for the analysis, and a sample checking method.
  • Patent Document 1 in order to detect whether or not the tip of a probe that sucks or discharges liquid has reached the liquid level, the level of serum is detected based on the amount of change in capacitance.
  • an automatic analyzer provided with a liquid level detection device that detects a true liquid level with reference to a liquid level detection based on a change in pressure in the probe during dispensing is disclosed.
  • pretreatment Technology that automatically performs the necessary processing (centrifuge processing, plugging processing, dispensing processing, etc., hereinafter referred to as pretreatment) before putting the biological sample into the automatic analyzer, and automatic transport to the automatic analyzer
  • pretreatment A technique for performing the above is provided as a pretreatment system.
  • the dispensing process is a subdivision process for creating a child sample to be transported to the automatic analyzer.
  • the number of child samples and the amount dispensed have been determined according to the requested items. Therefore, if the amount of collected biological sample is small and less than the amount required for the measurement of the requested item, the dispensing process is not completed and the process is not completed. There were times when it ended. This led to wasteful consumption of the child sample container and the barcode attached thereto.
  • a barcode label containing important information such as patient ID, personal information, and parameters necessary for device operation is attached to the surface of the container, and in some cases, the blood collection tube depends on the type of blood collection tube and the size of the label.
  • the entire tube wall is covered, or is overlaid with multiple labels. For this reason, the contents may become invisible from the outside. This has been an obstacle to capacity measurement in the field.
  • Patent Document 1 As a technique that can provide a useful result for this purpose even under such conditions, there is a technique as described in Patent Document 1, for example.
  • the detection method using the capacitance and the pressure in the probe as described in Patent Document 1 needs to contact the liquid surface with a dispensing probe, and wants to measure the volume of a biological sample before dispensing. It does not meet the request.
  • the liquid level can be detected in advance, there is an advantage in that the dispensing probe can be prevented from colliding with the separating agent during dispensing.
  • the object of providing information for controlling a workflow for quickly and accurately grasping the state cannot be achieved.
  • the shape of a container may be prepared for each test object such as for serum testing or urine testing, or may be prepared depending on test items such as for hematology testing or biochemical testing.
  • Each container is developed, manufactured and put on the market based on the shape of each manufacturer's original design concept.
  • the pretreatment system is introduced into a relatively large facility, and a wide variety of containers are used in the operation of the system in such a facility, and the charging order is irregular. Therefore, it is necessary to construct a technique that can withstand the practicality of the inspection apparatus system.
  • the present invention relates to a specimen that can achieve an improvement in processing capacity in a specimen test automation system for performing a pretreatment of a specimen or the like to be put into an automatic analyzer that performs qualitative / quantitative analysis of the component concentration of a biological sample, for example.
  • An inspection automation system, a check module, and a sample checking method are provided.
  • the present invention includes a plurality of means for solving the above-mentioned problems.
  • a sample test automation system for checking a sample contained in a container, which is input into the sample test automation system.
  • the specified part for specifying the type of the container, the stopper type of the container, and the upper surface of the sample in the container in a non-contact manner according to the type of the container specified by the specifying part and the stopper type of the container An irregularly shaped container corresponding measuring unit that is detected by the electrostatic capacity method, a vertically moving unit that moves the irregularly shaped container corresponding measuring unit up and down relative to the container, and information on the plug type specified by the specifying unit And a control unit that controls to detect the upper surface of the sample in the container while moving the measurement unit corresponding to the irregularly shaped container up and down with respect to the container by the vertical movement unit. Characterized in that was.
  • the conventional visual confirmation work can be reduced, and thus the sample in the container contributes to the reduction of manual work and the optimization of a complicated processing flow composed of a plurality of analysis items. Therefore, it is possible to improve the detection accuracy for obtaining information on the information, and to improve the processing capability.
  • FIG. 1 is a configuration diagram showing an overall configuration of a sample test automation system according to a first embodiment of the present invention and a positional relationship with an automatic analyzer. It is a figure which shows an example of the outline of the sample container checked with the sample test automation system in the 1st Embodiment of this invention. It is a figure which shows an example of the outline of the sample container checked with the sample test automation system in the 1st Embodiment of this invention. It is a figure which shows an example of the outline of the sample container checked with the sample test automation system in the 1st Embodiment of this invention.
  • FIG. 1 is a block diagram showing a positional relationship between an overall configuration of a sample test automation system and an automatic analyzer according to an embodiment of the present invention.
  • a biological sample (blood) collected from a patient is preprocessed and automatically analyzed.
  • the structure analyzed with an apparatus is shown.
  • the specimen test automation system for checking a biological sample contained in a container 101 includes a transport line 2, a loading module 201, a centrifuge module 202, a biological sample check module 203 a, a capping module 204, a labeler 205, a minute
  • the sample pretreatment system 200 includes a plurality of modules including a note module 206, a capping module 207, a classification module 208, and a storage module 209 as basic elements, and a control personal computer 210 that controls the entire sample pretreatment system 200.
  • Connected to the tip of the sample pretreatment system 200 is an automatic analyzer 211 that performs qualitative and quantitative analysis of the component concentration of the biological sample.
  • the loading module 201 is a module for loading the container 101 containing the sample into the sample pretreatment system 200, and includes a camera (container information acquisition unit) 221.
  • the centrifuge module 202 is a module that centrifuges the input specimen.
  • the opening module 204 is a module for opening the stopper 102 of the container 101 containing the centrifuged specimen.
  • the dispensing module 206 is used to analyze the sample in the centrifuged container 101 based on information on the sample volume calculated in the volume calculation unit 19d2 described later, or to analyze the uncentrifuged sample with the automatic analyzer 211 or the like. It is a module to subdivide.
  • the labeler 205 is a module that attaches a barcode to a container that accommodates a sample to be subdivided by the dispensing module 206.
  • the closing module 207 is a module for closing the stoppers on the subdivided containers and the dispensing source container 101.
  • the classification module 208 is a module that classifies the dispensed containers.
  • the storage module 209 is a module that stores a closed container.
  • the control personal computer 210 controls the operation of each module in the sample pretreatment system 200 and each mechanism in each module.
  • the conveyance line 2 is a line for conveying the charged container 1 to each module.
  • blood is taken as an example of the biological sample that is the contents of the container 101.
  • a container 101 having a separating agent 112 is used. From the top, the blood is separated into three layers of serum 111, separating agent 112, and blood clot 113 by centrifugation after blood collection.
  • the container 101 is provided with a stopper 102 and a barcode 103.
  • the barcode is attached in a state where the size of the barcode 103 as shown in FIG. 2 is smaller than the diameter of the container 101 and attached only on one side, that is, the state 104 where the contents can be seen from the gap,
  • the measurement object includes a container 101 that has not been centrifuged after blood collection.
  • the state 106 is a two-layer structure 106 of whole blood 117 and the separating agent 112 that has sunk down.
  • the present invention can uniformly cope with any state. This will be described below with reference to the example of the three-layer structure shown in FIGS.
  • FIG. 5 is a schematic diagram of a module having a function of measuring the volume of a biological sample in the sample test automation system according to an embodiment of the present invention.
  • the biological sample volume measuring device 1 is installed in the biological sample check module 203a of the specimen pretreatment system 200 as shown in FIG.
  • the transport line 2 relating to the biological sample check module 203a includes a main line 2d that transports the container 101 that stops at the biological sample check module 203a, an overtaking line 2c that transports the passing container 101 without stopping at the biological sample check module 203a, and a waiting for measurement. Consists of four lines: a buffer line 2b that allows the container 101 to temporarily stand by and stop for measurement, and a carry-out line 2a that performs measurement and returns the container 101 after measurement to the main line 2d. Has been. Arrows 3a, 3b, 3c indicate the moving direction of the line 2.
  • the device 1 is installed on the carry-out line 2 a shown in FIG. 5, and the position of the device 1 becomes the measurement position 7. Below the measurement position 7, a sensor (for example, RFID) that detects the arrival of the holder 4 holding the container 101 and a stopper that stops the holder 4 at the measurement position 7 are provided.
  • a sensor for example, RFID
  • FIG. 6 is a configuration diagram (side view) of a mechanism for measuring the volume of a biological sample according to an embodiment of the present invention, and shows a state immediately before the start of measuring the volume as a representative example.
  • the biological sample volume measuring device 1 includes, as one of main components, a detection mechanism 12, a rotating rod 17 for moving the detection mechanism 12 up and down, and a motor 11 that rotates the rotating rod 17. have.
  • the rotating rod 17 has a screw, and the detection mechanism 12 connected to the rotating rod 17 operates in the direction of the arrow 13a.
  • the detection mechanism 12 has a capacitance sensor 31 at its left and right center positions, and an irradiation section 21 and a light receiving section 22 at positions that are symmetrical with respect to the center line.
  • the capacitance sensor 31 provided in the device 1 is a sensor that detects the upper surface of the sample in the container 101 from the outside of the container 101 by a non-contact capacitance method, and is excellent in liquid detection.
  • the non-contact capacitance method will be briefly described below.
  • a positive voltage is applied to a certain conductor (hereinafter referred to as an electrode) with respect to the ground, a positive charge is generated in the electrode, and an electric field is generated between the electrode and the ground.
  • an oscillation circuit is used for the detection circuit, and the capacitance C of a terminal (electrode) of the oscillation circuit is used.
  • the oscillation circuit is configured so that becomes an element of the oscillation condition, and an object approaching the electrode is detected by starting or stopping oscillation according to the change in C of the electrode.
  • the change in the capacitance of the electrode is related to the size, thickness, and relative permittivity ⁇ s in the case of a dielectric, and the capacitance change is larger as ⁇ s is larger, thicker, and larger ⁇ s.
  • This relative dielectric constant ⁇ s indicates the degree to which the charge in the object is polarized due to electrostatic induction. If it is 1 on the basis of the vacuum, the liquid is relatively large including about 80 of water, and 10 for the solid. There are many of the following. From this, by detecting the change in capacitance of the electrode when an object approaches the detection electrode and detecting the difference in capacitance, the liquid phase and other layers (gas phase, solid layer) Detect boundaries.
  • the capacitance sensor 31 is used to detect the upper surface 114 of the serum 111 (the boundary between the serum 111 and the air layer).
  • the irradiation unit 21 irradiates the side surface of the container 101 with light.
  • the light receiving unit 22 measures the amount of transmitted light irradiated from the irradiation unit 21 and passed through the container 101. That is, the light detection system including the irradiation unit 21 and the light receiving unit 22 detects a boundary between layers based on a difference in transmitted light amount, and is excellent in detecting a boundary between an optically thick layer and a layer that is not. .
  • a fiber sensor that is resistant to noise is suitable for the light receiving unit 22.
  • a photodiode, CCD, CMOS or the like may be used.
  • an irradiation unit 21 that has a strong light quantity.
  • an LED light source is used.
  • the irradiation unit 21 may of course be a laser light source or a halogen lamp.
  • infrared light about 940 nm
  • the wavelength band is not particularly limited as long as the transmittance is high.
  • LED infrared light as irradiation light easily passes through relatively optically thin layers such as serum 111 and separating agent 112.
  • This feature is an invariable principle even when the barcode 103 is pasted as described above.
  • an optically thick layer such as the clot 113 is difficult to transmit.
  • this feature is used to detect the interface 116 between the optically thick clot 113 and the optically relatively thin separation agent 112.
  • a threshold value for distinguishing the transmitted light amount of the LED light with respect to the serum 111 and the separating agent 112 and the transmitted light amount of the LED light with respect to the blood clot 113 is installed in the signal amount acquisition unit 19b in advance.
  • the transmitted light amount of LED light with respect to the blood clot 113 is extremely smaller than the transmitted light amount of LED light with respect to the serum 111 or the separating agent 112, so that it can be detected without variation largely without depending on the threshold value.
  • the electrostatic capacitance sensor 31 and the light detection system can stably detect the upper surface 114 and the boundary surface 116.
  • the upper surface 114 and the boundary surface 116 are detected by moving the detection mechanism 12 including the capacitance sensor 31 and the light detection system from the upper side to the lower side of the container 101.
  • a method of fixing the detection mechanism 12 with a sensor and moving the container 101 up and down is common.
  • the serum 111 is shaken, which causes a measurement error. Therefore, in this embodiment, measurement is performed by moving the detection mechanism 12 up and down without moving the container 101.
  • the distance between the center of the capacitance sensor 31 and the center of the irradiation unit 21 is set to an interval h0 corresponding to the width of the biological sample accommodated in the container 101.
  • This interval h0 is determined as follows.
  • the irradiation unit 21 shifts to detection of the boundary surface 116 between the separating agent 112 and the clot 113.
  • the detection mechanism 12 is controlled. Therefore, the boundary surface 116 is detected as soon as the detection by the capacitance sensor 31 is completed, that is, the shorter the scanning time by the irradiation unit 21, the better the processing capability.
  • the electrostatic capacitance sensor 31 reaches the upper surface 114 of the serum 111, it is desirable that the irradiation unit 21 be in the vicinity of the boundary surface 116.
  • the container 101 blood collection tube
  • the average amount of blood generally collected in the laboratory can be defined with a certain degree of accuracy. From this general amount, the average value of the serum 111 height can be determined to some extent.
  • the average value of the height of the serum 111 and the value obtained by adding the height of the separating agent 112 are the distance between the serum upper surface 114 and the boundary surface 116. This distance is set as the interval h0 described above.
  • the biological sample volume measuring apparatus 1 further includes a configuration for accommodating containers 101 having different shapes as main components.
  • the horizontal movement unit for moving the capacitance sensor 31 in the horizontal direction (the direction of the arrow 13b in FIG. 6) according to the shape, particularly the diameter, of the container 101 to be measured.
  • the motor 24 for rotating the rotating rod 25 is provided as the horizontal movement unit for moving the capacitance sensor 31 in the horizontal direction (the direction of the arrow 13b in FIG. 6) according to the shape, particularly the diameter, of the container 101 to be measured.
  • the motor 24 for rotating the rotating rod 25 is provided.
  • the rotating rod 25 has a screw, and the detection mechanism 12 connected to the rotating rod 25 operates in the direction of the arrow 13b.
  • the biological sample volume measuring device 1 includes a control unit 19a, a signal amount acquisition unit 19b, a data storage unit 19c, an analysis calculation unit 19d, and a communication line 18 for exchanging control signals and sensor signals as main components. ing.
  • the control unit 19a controls the operation of each element in the device 1 described above.
  • the control unit 19a recognizes that the container 101 containing the sample is loaded in the loading module 201
  • the control unit 19a controls the camera 221 to perform imaging of the loaded container 101.
  • the motor 24 is controlled so as to move the capacitance sensor 31 in the horizontal direction with respect to the container 101, and specified by the container information specifying unit 19d1 while moving the capacitance sensor 31 in the vertical direction with respect to the container 101.
  • the motor 11, the capacitance sensor 31, and the irradiation unit 21 so as to detect the upper surface 114 of the sample in the container 101 and the boundary surface 116 between the separating agent 112 and the blood clot 113 according to the information on the type of the stopper 102 that has been provided. And controls the light receiving unit 22.
  • the control unit 19a determines the distance between the container 101 and the capacitance sensor 31 based on the shape of the container 101 specified by the container information specifying unit 19d1, particularly information on the diameter of the container 101.
  • the horizontal movement distance of the capacitance sensor 31 is calculated so as to be an optimum distance for the detection, and the calculation result is output to the motor 24 as a signal.
  • the motor 24 is rotated by this movement distance signal, and the rotating rod 25 is rotated by this rotational movement, whereby the detection mechanism 12 is operated in the direction of the arrow 13b.
  • the detection mechanism 12 moves (moves to the position 12a or 12b)
  • the position of the capacitance sensor 31 also moves (moves to the position 31a or 31b).
  • the “optimum distance” is determined in advance for each type of container 101 and is stored in advance in the data storage unit 19c so that it can be referred to when necessary.
  • the sensitivity of the electrostatic capacity sensor 31 increases as it approaches the wall surface of the container 101. However, if the electrostatic capacity sensor 31 is too close, it reacts easily with objects other than the liquid surface and false detection increases. On the other hand, if the capacitance sensor 31 is moved away from the wall surface of the container 101, the sensitivity is deteriorated, and the error in detecting the liquid level is increased. Due to the balance of both effects, there is an optimum interval for each container.
  • the detection mechanism 12 is moved so that the capacitance sensor 31 approaches the container 101 (for example, the position of 12b (dotted line)), and in the case of a 16 mm diameter container, the capacitance sensor 31. Is moved away from the container 101 (for example, the position of 12a).
  • the distance between the wall surface of the container 101 and the capacitance sensor 31 is optimally about 1 cm for a 13 mm diameter container, and about 1.5 cm is optimal for a 16 mm diameter container.
  • FIG. 7 is an example of experimental data indicating the sensitivity of the capacitance sensor.
  • the horizontal axis is the height position of the container, the unit is mm, and the one closer to the origin corresponds to the upper part of the container.
  • the vertical axis is a voltage value obtained by converting the capacitance value, and the unit is V.
  • the output of the capacitance sensor 31 during detection of the upper surface of the sample is only ON and OFF, but in this figure, analog data is shown as an output on the vertical axis in order to explain the sensitivity of the sensor.
  • Solid line 311 indicates capacitance data for a 13 mm diameter container (the distance between the sensor and the container is equal to the distance for the 16 mm container), and thick line 312 indicates capacitance data for the 13 mm diameter container (the distance between the sensor and the container for the 16 mm container).
  • the broken line 314 is the capacitance data for a 16 mm diameter container shown as a reference value.
  • the difference in capacitance before and after the liquid level 313 is large and sharp.
  • a large difference in capacitance indicates that the liquid level 313 can be easily detected, and a sharp difference indicates that an accurate position can be detected.
  • the detection sensitivity for the 16 mm container is high.
  • the waveform is slightly smooth and before and after the liquid level as shown by the solid line 311 in FIG.
  • the sensitivity is small compared to the result of the 16 mm container.
  • the distance between the capacitance sensor 31 and the container 101 is reduced, the waveform before and after the liquid level 313 becomes sharp and the difference increases as indicated by the thick line 312 in FIG.
  • the sensitivity of the capacitance sensor can be improved by adjusting the distance of the sensor.
  • FIG. 8 is an explanatory diagram showing sensor control and output for measuring the volume of a biological sample according to an embodiment of the present invention.
  • the capacitance sensor 31 is stationary at the position above the stopper 102. In this state, the power supply 64 is OFF.
  • the control unit 19a moves the detection mechanism 12 downward and turns the sensor power supply 64 from OFF to ON at the timing when the capacitance sensor 31 reaches the bottom of the plug 102 (62a).
  • the reason for such control is that if the power supply 64 of the capacitance sensor 31 is always turned on, the output 65 may be turned on due to the presence of the plug 102, and thus the position of the plug can be determined. Misrecognized as the upper surface of serum. Therefore, for the purpose of preventing this erroneous recognition, a control method is adopted in which the power source 64 is initially turned off and the power source 64 is turned on only after the capacitance sensor 31 passes through the plug 102. The position of the bottom of the stopper 102 is determined depending on the container 101, and the information is specified by the container information specifying unit 19d1 described later.
  • the capacitance sensor 31 is normally set to be OFF and ON for the detection of the serum 111. Therefore, when the capacitance sensor 31 reaches the serum upper surface 114, the sensor output 65 is switched from OFF to ON (62b). The serum upper surface 114 is detected by this output switching.
  • the control unit 19a turns off the power source 64 of the capacitance sensor 31 (63a) and simultaneously turns on the power source 66 of the irradiation unit 21 from OFF (62c).
  • the output 65 returns to OFF (63b), and the irradiation unit 21 is at the position of the serum 111, so that the output of the light receiving unit 22 is turned on (62d).
  • the output 67 of the light receiving unit 22 is the amount of light transmitted through the container 101.
  • a threshold value for distinguishing the transmitted light amount of the LED light with respect to the serum 111 and the separating agent 112 and the transmitted light amount of the LED light with respect to the blood clot 113 is installed in the data storage unit 19c in advance.
  • the LED light 23 is blocked by the blood clot 113, and the amount of transmitted light continues.
  • the output 67 is turned OFF (63d). By this output switching, the boundary surface 116 between the separating agent 112 and the blood clot 113 is detected.
  • control unit 19a turns off the power of the irradiation unit 21 (63c).
  • control unit 19a When the electrostatic capacitance sensor 31 and the irradiation unit 21 are both in the OFF state, the control unit 19a returns the detection mechanism 12 to the upper position of the stopper 102, which is the original position, in preparation for the next specimen measurement.
  • the signal amount acquisition unit 19b acquires the signal amounts of the capacitance sensor 31 and the light receiving unit 22 (both are collectively referred to as sensor signals).
  • the data storage unit 19c stores the signal amount of the capacitance sensor 31 and the light receiving unit 22 acquired by the signal amount acquisition unit 19b, and information processed by each unit of the analysis calculation unit 19d described later.
  • the analysis calculation unit 19d includes a container information specifying unit 19d1 and a capacity calculation unit 19d2.
  • the container information specifying unit 19d1 specifies the type of the container 101 put into the charging module 201 and the type of the stopper 102 of the container 101. Specifically, the container information specifying unit 19d1 recognizes the type of the container 101 by performing image processing on the captured image of the container 101 that has been imaged by the camera 221 and that has been input to the input module 201. As a recognition method, for example, there is a method of providing a database in which a container to be used in advance is photographed and performing matching with a captured image. Further, the container information specifying unit 19d1 acquires information on the position of the bottom of the stopper 102 attached to the container 101 and the diameter of the container 101 from the type of the container 101. The obtained information is transmitted to the control personal computer 210.
  • This information is also transmitted to the analysis calculation unit 19d of the biological sample volume measuring device 1 via the biological sample check module 203a, the stage 15b, and the communication line 18.
  • the position of the bottom of the stopper 102 of the container 101 is used as information for determining a position where the power source 64 of the capacitance sensor 31 is turned on in the control unit 19a.
  • the diameter information of the container 101 is calculated together with the height information of the serum 111 and the whole blood 117 obtained by the measurement of the biological sample volume measuring device 1, and the volume of the serum 111 and the whole blood 117 is calculated in the volume calculation unit 19d2. Used when doing.
  • the capacity calculation unit 19d2 specifies the diameter of the container 101 and the presence or absence of the separating agent 112 from the type of the container 101 specified by the container information specifying unit 19d1, and obtains the boundary surface 116 between the clot 113 and the separating agent 112. Then, the capacity of the sample in the container 101 is calculated from this identification result, information on the boundary surface 116, and information on the upper surface 114 of the sample in the container 101 detected by the capacitance sensor 31. Specifically, the capacitance calculation unit 19d2 first determines the high level of the detection mechanism 12 from the signal amount of the capacitance sensor 31 (the state of whether the capacitance sensor 31 is OFF or ON) acquired by the signal amount acquisition unit 19b. Information h1 is obtained.
  • This height (h1) is calculated by subtracting the movement distance corresponding to the rotation speed of the motor 11 from the initial position. Further, the height information h2 of the detection mechanism 12 is obtained from the signal amount of the light receiving unit 22 (the value at which the value of the transmitted light detected by the light receiving unit 22 rapidly decreases), and based on the amount of transmitted light measured by the light receiving unit 22, the container A boundary surface 116 between the clot 113 and the separating agent 112 in 101 is obtained. This height (h2) is calculated by subtracting the moving distance corresponding to the rotation speed of the motor 11 from the initial position. Thereafter, the height hs of the h1-h2-separating agent 112 is calculated to calculate the serum 111 height.
  • the amount of the separating agent 112 is known to be a substantially constant value depending on the type of the container 101, and therefore is stored in advance in the analysis calculation unit 19d as a fixed value. Therefore, the height hs of the separating agent 112 is obtained from the container information specified by the container information specifying unit 19d1 by calculating from the diameter information of the container 101 and the amount information of the separating agent 112. Thereafter, the volume of the serum 111 is calculated as a specific volume value by using information regarding the diameter of the container 101.
  • the device 1 also includes a stage 15b for physically communicating with other modules of the sample pretreatment system 200 and the control personal computer 210.
  • the user inputs the container 101 containing blood into the input module 201.
  • the camera 221 recognizes the type of the container 101.
  • the container 101 containing the blood is installed on the dedicated holder 4, moves on the transport line 2, and is transported to the centrifuge module 202 as necessary. For example, if it corresponds to an item such as a blood cell counter, the centrifuge module 202 is skipped and allowed to pass through without being centrifuged.
  • the container that has been subjected to the centrifugal separation process is transported to the biological sample check module 203a to measure the capacity. The measured capacity is transmitted by the control personal computer 210.
  • control personal computer 210 starts a process for determining a subdivision plan (number of subdivisions, subdivision amount, etc.).
  • the subdivision schedule is basically determined by the requested measurement item, but in this embodiment, capacity is further taken into account. For example, when all the analysis is possible or not possible with the measured capacity among the requested items, an appropriate subdivision is made using as parameters the number of items that can be analyzed.
  • the container 101 for which the volume measurement has been completed in the biological sample check module 203a is carried to the opening module 204 and an opening process is performed.
  • the preparation of the subdividing container based on the above-described schedule is performed by the labeler 205, and then the actual subdividing is performed by the dispensing module 206. After that, depending on the application, after being transported to the automatic analyzer 211 and subjected to a closing process by the closing module 207, classification by the classification module 208 or storage in the storage module 209 is performed.
  • the container 101 transported to the biological sample check module 203a is transported to the measurement position 7 through the buffer line 2b.
  • the sensor detects the holder 4 and transmits the information to the control personal computer 210, and the control personal computer 210 transmits a processing start instruction signal to the control unit 19 a of the device 1.
  • the stopper is operated, and the container 101 is stopped at the measurement position 7 during measurement.
  • the container 101 stops at the center position (measurement position 7) of the detection mechanism 12 while being placed on the holder 4.
  • the control unit 19 a calculates the rotation amount of the motor 24 based on the information on the container 101 specified by the container information specifying unit 19 d 1, particularly information on the diameter of the container 101, and outputs it to the motor 24.
  • the motor 24 is rotated, and the rotating rod 25 is rotated by this rotational movement so that the detection mechanism 12 (capacitance sensor 31) approaches the container 101 (positions 12b and 31b), or It moves away (positions 12a and 31a), and when it reaches the detection execution position, the motor 24 stops and the rotating rod 25 and the detection mechanism 12 also stop.
  • step S41 measurement on the container 101 is started (step S41).
  • the height of the detection mechanism 12 from the stage is a fixed position (hereinafter referred to as an initial position) that is taught in advance in the manufacturing stage.
  • step S42 When the motor 11 is operated by the controller 19a, the rotating rod 17 rotates in the direction of the arrow 16 and the detection mechanism 12 descends in the direction of the arrow 13a (step S42).
  • the power supply of the capacitance sensor 31 is switched on. This position depends on the type of the stopper 102 of the container 101, and is known in advance by the container information specifying unit 19d1. Thereafter, the signal is continuously lowered while being transmitted to the signal amount acquiring unit 19b through the communication line 18, and it is continuously determined whether the output information of the capacitance sensor 31 is ON or OFF (step S43). The descent continues until it is turned ON.
  • the control unit 19a gives a stop signal to the motor 11 through the communication line 18 and instantaneously stops the detection mechanism 12 (step S46).
  • the motor 11 that has received this signal stops, and the rotating rod 17 and the detection mechanism 12 stop in conjunction with this.
  • the data storage unit 19c records the height information (h1) of the detection mechanism 12 (step S47).
  • the control unit 19a After the height h1 is recorded, the control unit 19a then sends a light emission signal to the irradiation unit 21 through the communication line 18 to detect the boundary surface 116 between the separating agent 112 and the clot 113, and electrostatically A signal for turning off the power of the capacitance sensor 31 is output.
  • the electrostatic capacity sensor 31 that has received this signal is turned off, and the irradiating unit 21 is turned on to start LED emission (step S48).
  • the control unit 19a again gives an operation signal to the motor 11 through the communication line 18, and the motor 11 that has received this signal starts to rotate, and the detection mechanism 12 resumes descent in conjunction with this (step S49). ).
  • the light receiving unit 22 on the light receiving side measures the value of the transmitted light and constantly transmits this information to the signal amount acquiring unit 19b via the communication line 18, and is below a predetermined threshold value. Is monitored (step S50). When it is larger than the predetermined threshold value, the detection mechanism 12 continues to descend (in the case of No in step S50).
  • the control unit 19a gives a stop signal to the motor 11 through the communication line 18, and the motor 11 that has received this signal stops, and in conjunction with this, the rotating rod 17 and the detection mechanism 12 stop (step S53). .
  • the data storage unit 19c records the height information (h2) of the detection mechanism 12 (step S54).
  • the control unit 19 a After the height h ⁇ b> 2 is recorded, the control unit 19 a sends a stop signal to the irradiation unit 21 through the communication line 18 to stop the LED emission by the irradiation unit 21. This is a measure for not shortening the life of the LED light source.
  • control unit 19a controls the detection mechanism 12 to return to the initial position in preparation for the next measurement of the container 101 (step S55). Specifically, the operation signal is again given to the motor 11 through the communication line 18. Receiving this signal, the motor 11 starts rotating, and the detection mechanism 12 starts to rise in conjunction with the rotation. In addition, when raising the detection mechanism 12, it is good to operate the motor 11 in the reverse direction to the case of a fall.
  • the capacitance calculation unit 19d2 of the analysis calculation unit 19d receives the height information (h1) of the detection mechanism 12 based on the information on the state (OFF or ON) of the capacitance sensor 31 recorded in step S47. Then, the height of the serum 111 is calculated using the information with the height information (h2) of the detection mechanism 12 recorded in step S54. Next, the volume calculation unit 19d2 uses the information regarding the diameter of the container 101 specified by the container information specifying unit 19d1 and the information about the height of the serum 111 obtained previously, so that the volume of the serum is obtained as a specific volume value. Is calculated.
  • the container 101 is imaged by the camera 221, and the type of the container 101 and the type of the stopper 102 of the container 101 are specified by the container information specifying unit 19d1. Then, the detection mechanism 12 is moved in the horizontal direction so that the detection accuracy by the capacitance sensor 31 is increased. Thereafter, the capacitance sensor 31 is moved downward, and the timing at which the capacitance sensor 31 reaches the bottom of the plug 102 is specified from the information on the type of the specified plug 102. At this timing, the sensor power supply 64 is turned off. The upper surface 114 of the serum 111 is detected by the capacitance sensor 31.
  • the blood clot 113 is detected by the transmitted light amount acquired by the light receiving unit 22 using a light detection system including the irradiation unit 21 and the light receiving unit 22. And the boundary surface 116 between the separation agent 112 and the separation agent 112 are detected. Then, the height and volume of the serum 111 are calculated from the upper surface 114 and the boundary surface 116.
  • the container 101 has a different shape and diameter, or the inside of the container 101 is in a state in which the inside is not visible with a barcode label. Even if the shape and state of the blood vessel are not constant, the upper surface 114 of the serum 111 and the boundary surface 116 between the separating agent 112 and the blood clot 113 in the specimen in the container 101 can be obtained even if the user puts the container 101 without consciousness in advance. It is possible to detect with high accuracy, and the height of the measurement object, and thus the capacity, can be calculated by only one scanning, and information on the capacity can be acquired more quickly than in the past.
  • the conventional visual confirmation work can be reduced, the manual work of the user can be reduced, and information on the volume of the biological sample can be obtained, so that prioritization of measurement items can be performed,
  • the processing order can be optimized. Therefore, a specimen test automation system and a sample check method capable of reducing the burden on the patient and preventing the delay in reporting the processing result are provided. Furthermore, since instructions for blood collection can be promptly issued as necessary, it contributes to reducing the burden on patients and preventing delays in reporting processing results. Accompanying this, it is possible to reduce the possibility of infection accompanying the contact of the worker.
  • the capacitance sensor 31, the irradiation unit 21, and the light receiving unit 22 are arranged at intervals according to the width of the biological sample accommodated in the container 101, so that the detection by the capacitance sensor 31 is completed. After that, the boundary surface 116 is immediately detected, and the scanning time by the irradiating unit 21 can be shortened, thereby improving the processing capability.
  • the holder 4 When measurement in the biological sample check module 203a is not required, such as when a retest is requested or when a user's judgment is prioritized, the holder 4 is transported to the overtaking line 2c according to an instruction from the control personal computer 210 or the like. Can be processed without measurement.
  • the control unit 19a does not move the detection mechanism 12 in the waterside direction without operating the motor 24, but the shape of the container 101 (for example, an inverted cone) Depending on the shape and the like, it is possible to control the detection of the upper surface 114 by the capacitance sensor 31 while operating the motor 24 so as to keep the distance between the capacitance sensor 31 and the container 101 appropriate.
  • the irradiation direction of the LED light in the irradiation unit 21 may be opposite to the above-described direction.
  • FIG. 10 is a diagram showing an outline of a configuration for measuring the volume of a biological sample in the sample test automation system according to the second embodiment of the present invention.
  • the biological sample volume measuring device 1 As shown in FIG. 10, in the biological sample volume measuring device 1 according to the present embodiment, as a configuration for dealing with containers 101 having different shapes, instead of the horizontal direction moving unit of the capacitance sensor 31, for long distance use.
  • the long-distance capacitance sensor 33 is relatively larger in size than the short-distance capacitance sensor 34.
  • the control unit 19a selects either the long-distance capacitance sensor 33 or the short-distance capacitance sensor 34 according to the diameter of the container 101 specified by the container information specifying unit 19d1. Select whether to use the sensor. For example, if the container has a diameter of 13 mm, the long-distance electrostatic capacity sensor 33 is selected to be used, and if the container has a diameter of 16 mm, the short-distance electrostatic capacity sensor 34 is selected. The liquid level is controlled to be detected. At this time, the stop position (measurement position 7) of the container 101 is also adjusted and fixed so that the container 101 is directly below the selected capacitance sensor.
  • the senor is used depending on the container 101, so that the sample test automation system and the sample check method described above can be compared with the first embodiment. In substantially the same manner, even when the shape and state of the container 101 are not constant, an effect that the measurement accuracy can be ensured can be obtained.
  • the types of capacitance sensors provided are not limited to two types, and three or more types can be used so that the containers 101 having different shapes can be finely accommodated.
  • FIG. 11 is a diagram showing an outline of a configuration for measuring the volume of a biological sample in a sample test automation system according to the third embodiment of the present invention.
  • the biological sample volume measuring device 1 includes a detection mechanism 35 instead of the detection mechanism 12 as a configuration for dealing with containers 101 having different shapes.
  • the detection mechanism 35 has a box shape when the device 1 is viewed from above, and the two capacitance sensors 38 and 39 are arranged inside each other so as to face each other.
  • two circles 101a and 101b drawn inside the detection mechanism 35 represent measurement positions of the 16 mm diameter container 101a and the 13 mm diameter container 101b, respectively.
  • the 13 mm diameter container 101b is measured by the electrostatic capacity sensor 38 disposed on the lower side of FIG. 11, and the 16 mm diameter container 101a is measured by the electrostatic capacity sensor 39 disposed on the upper side. Has been.
  • control unit 19a appropriately adjusts the arrangement of the capacitance sensors 38 and 39 according to the diameter of the container 101 specified by the container information specifying unit 19d1, thereby adjusting the diameter of the container 101. Therefore, it is possible to measure at the same measurement position 7. This will be specifically described below with reference to FIG.
  • L be the distance between the two capacitance sensors 38 and 39.
  • the distances (hereinafter, detectable distances) for obtaining an effective measurement result are D1 and D2, respectively.
  • the radius of the outer edge of the 13 mm diameter container 101b is r1
  • the radius of the outer edge of the 16 mm diameter container 101a is r2.
  • a coordinate y with the detection surface of the capacitance sensor 38 as the origin is set, and the center point of the 13 mm diameter container 101b and the center point of the 16 mm diameter container 101a are set as y1 and y2, respectively.
  • y2 is L ⁇ (r2 + D2) ⁇ y2 ⁇ L ⁇ r2 (Condition 3) It is necessary to satisfy.
  • both D1 and D2 are 2.0, it means that a long-distance sensor that can be measured even at a distance of 2.0 mm is used for both capacitance sensors 38 and 39.
  • the center points y1 and y2 of the container which means that both the 13 mm container 101b and the 16 mm container 101a can be measured at the same measurement position.
  • the middle point (see the center line 36) of both the capacitance sensors 38 and 39 is the point of the coordinate 8.5, whereas the center line 37 passing through the center of the container 101 is the coordinate. It is the point of 8.25.
  • both the capacitance sensors 38 and 39 are non-targeted with respect to the container 101.
  • the distance d1 between the outer edge of the 13 mm diameter container 101b and the lower sensor 38 is 1.75
  • the distance d2 between the outer edge of the 16 mm diameter container 101a and the upper sensor 39 is 0.75. Within possible distance. It can also be seen that none of the containers physically interfere with the capacitance sensors 38 and 39.
  • the distance d1 between the outer edge of the 13 mm diameter container 101b and the capacitance sensor 38 is 1.55, and the distance d2 between the outer edge of the 16 mm diameter container 101a and the upper sensor 34 is 0.75. It can be seen that it is within the detectable distance. It can also be seen that none of the containers physically interfere with the sensors 38, 39.
  • the third embodiment of the specimen test automation system and the sample check method of the present invention also includes the first and second embodiments of the specimen test automation system and the sample check method described above.
  • the measurement accuracy is ensured at the common measurement position without changing the measurement position for each diameter of the container 101 by appropriately arranging the capacitance sensor. The effect that it can measure in a state is acquired.
  • FIG. 12 is a diagram showing an outline of a module having a function of measuring the volume of a biological sample in the specimen test automation system according to the fourth embodiment of the present invention.
  • the biological sample check module (check module) 203b is provided with a camera 221b, not the input module 201.
  • this recognition method includes, for example, a method in which a database in which a container to be used is captured is provided and matching is performed with the captured image.
  • the container information specifying unit 19d1 recognizes the type of the container 101, thereby specifying the diameter of the container 101, the type of the stopper 102, and the position of the bottom of the stopper 102. These pieces of information are used as information for calculating the position at which the power supply 64 of the capacitance sensor 31 is turned on and the capacity of the serum 111. Subsequent operations are substantially the same as those in the first embodiment.
  • the check module alone can grasp the state of the sample in the blood collection tube, and can be a module suitable for addition to an existing specimen pretreatment system.
  • the check module as in the present embodiment can also be applied to the measurement of the remaining amount of reagent in the reagent container stored in the reagent cooler of the automatic analyzer 211. Since the reagent stored in the reagent cooler is usually operated in a colored container for light shielding purposes, the remaining amount cannot be visually confirmed. However, since the check module as in this embodiment is provided in the reagent cooler of the automatic analyzer 211 or in the vicinity thereof, the remaining amount of the reagent in the reagent container can be checked even in a situation where the reagent capacity cannot be visually confirmed. Is possible.
  • FIG. 13 is a diagram showing an outline of a module having a function of measuring the volume of a biological sample in a sample test automation system according to the fifth embodiment of the present invention.
  • a lifting mechanism 71 is provided for volume measurement by the biological sample volume measuring device 1. Control of each operation of the lifting mechanism 71 is performed by the control unit 19a. Specifically, after grasping the container 101 by the lifting mechanism 71, the lifting mechanism 71 is raised in the direction of the arrow 73 until the bottom side of the container 101 becomes higher than the rack 72 and stopped. Thereafter, in the stopped state, the volume measurement by the biological sample volume measuring device 1 is performed as in the first embodiment.
  • the sample test automation system, the check module, and the sample checking method of the present embodiment are also applied to uncentrifuged blood. Is applicable.
  • FIG. 4 described above a two-layer structure of the whole blood 117 and the separating agent 112 that has sunk down is formed, and the blood clot 113 does not exist.
  • the amount of transmitted light does not decrease and h2 is not detected, or the blood clot 113 is continuously searched and scanned, and the LED light 23 descends to the height of the holder 4, and this back blocks the transmission.
  • h2min a threshold value for h2 (for example, h2min) is provided in advance, and if h2 ⁇ h2min, or if h2 is not found, the control unit uniformly considers the sample as uncentrifuged.
  • 19a, signal amount acquisition unit 19b and analysis calculation unit 19d are set in advance.
  • the height of h1-separating agent is the height of the whole blood 117.
  • capacitance of the whole blood 117 is calculated as a concrete volume value by using the information regarding the diameter of the container 101 specified in the container information specific
  • specimen test automation system the check module, and the sample check method of the present embodiment can be applied even when containers without a separating agent coexist. This will be described below.
  • Some types of containers 101 have no separation agent, and are transported to the specimen pretreatment system 200 in a state where a container with a separation agent and a container without a separation agent are mixed.
  • the specimen In a container without a separating agent, the specimen has a two-layer structure of plasma and blood clot when centrifuged, or one layer of whole blood when not centrifuged.
  • the upper surface of the plasma is detected by the capacitance sensor 31 to obtain h1, and the boundary between the plasma and the clot is detected by the light detection system to obtain h2.
  • the upper surface of whole blood is detected by the capacitance sensor 31 and is set to h1, but since there is no boundary surface, boundary surface detection by the light detection system is impossible.
  • the type of the charged container 101 can be specified by the camera 221 such as the input module 201 or the container information specifying unit 19d1. Moreover, since the presence or absence of the separating agent is determined by the type of the container, the presence or absence of the separating agent can be known if the type can be specified.
  • control part 19a the signal amount acquisition part 19b, the data memory
  • the boundary surface 116 is detected using a light detection system, and the height and capacity of the serum 111 are calculated from the upper surface 114 and the boundary surface 116.
  • the volume of the serum 111 may be obtained from the information on the upper surface 114.
  • the container information specifying unit 19d1 can specify information regarding the presence or absence of the separating agent 112 in the container 101 and the diameter of the container 101.
  • the blood volume collected in the container 101 is not substantially different for each container 101 and is almost the same, and the solid layer (for example, the amount and height of the blood clot 113) in the blood volume is grasped to some extent. Can do. Therefore, by detecting the upper surface 114 by the capacitance sensor 31, the amount of liquid in the container 101 (for example, the volume of the serum 111) can be grasped with a certain degree of accuracy based on these pieces of information.
  • the irregularly shaped container corresponding measurement unit configured to accommodate differently shaped containers 101 includes a horizontal movement mechanism as in the first embodiment, and a plurality of static electricity as in the second and third embodiments. Not only the capacitance sensor but also a corresponding method by controlling the current value (gain) of the capacitance sensor 31 by the signal amount acquisition unit 19b or the analysis calculation unit 19d is also effective.
  • 1 biological sample volume measuring unit, 2 ... Conveying line, 2a ... Unloading line, 2b ... buffer line, 2c ... Overtaking line, 2d ... Main line, 3 ... transport direction, 4 ... Holder, 5 ... Camera, 6 ... Shading plate, 7 ... Measurement position, 11 ... motor, 12 ... detection mechanism, 12a, 12b ... the position of the detection mechanism, 13a, 13b ... arrows (arrows indicating the operating direction of the detection mechanism), 14 ... backboard, 15a ... stage, 15b ... stage, 17 ... rotating rod, 18 ... communication line, 19a ... control unit, 19b ... Signal amount acquisition unit, 19c: Data storage unit, 19d ... analysis operation part, 21 ...

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Abstract

La présente invention améliore la capacité de traitement de, par exemple, un système d'automatisation d'inspection d'échantillon destiné à réaliser le prétraitement sur un échantillon, ou similaire, inséré dans un dispositif d'analyse automatique pour analyse qualitative et quantitative d'une concentration de constituant d'un échantillon biologique. Un appareil photo (221) photographie un récipient (101) et une unité de spécification d'informations de récipient (19d1) spécifie le type de récipient (101) et le type de bouchon (102) de récipient (101). Un mécanisme de détection (12) est déplacé dans la direction horizontale de manière à améliorer la précision de détection d'un capteur de capacité (31). Le mécanisme de détection (12) est par la suite déplacé vers le bas. Sur la base des informations de type de bouchon (102) spécifié, une alimentation électrique (64) est allumée lorsqu'un capteur de capacité (31) atteint la base du bouchon (102), et la surface supérieure (104) de sérum (111) est détectée. Un système de détection optique est utilisé pour détecter l'interface (116) d'un caillot (113) et d'un agent de séparation (112) sur la base de quantités de transmittance acquises par une unité de réception de lumière (22). La hauteur et la quantité du sérum (111) sont calculées à partir de la surface supérieure (114) et de l'interface (116).
PCT/JP2015/057573 2014-04-17 2015-03-13 Système d'automatisation d'inspection d'échantillon, module de contrôle et procédé de contrôle d'échantillon WO2015159620A1 (fr)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3553528A4 (fr) * 2016-12-09 2020-07-08 Hitachi High-Tech Corporation Dispositif d'analyse d'échantillon biologique
CN112613139A (zh) * 2020-12-14 2021-04-06 成都飞机工业（集团）有限责任公司 一种理化试样自动排样的方法
KR20210088663A (ko) * 2018-11-08 2021-07-14 퍼킨엘머 헬스 사이언시즈, 아이엔씨. 버피 코트 이미지 촬상을 위한 방법 및 장치
US11263433B2 (en) 2016-10-28 2022-03-01 Beckman Coulter, Inc. Substance preparation evaluation system

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04218726A (ja) * 1990-01-18 1992-08-10 E I Du Pont De Nemours & Co 容量性液体境界面センサ
JP2000266768A (ja) * 1999-03-18 2000-09-29 Hitachi Ltd 自動分析装置
JP2008046033A (ja) * 2006-08-18 2008-02-28 Sysmex Corp 検体分析装置
JP2010133925A (ja) * 2008-10-31 2010-06-17 Sysmex Corp 検体処理装置
JP2010240510A (ja) * 2009-04-01 2010-10-28 Panasonic Corp ディスペンサおよび液状材料の残量確認方法
JP2014006094A (ja) * 2012-06-22 2014-01-16 Hitachi High-Technologies Corp 検出装置および生体試料分析装置

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001108506A (ja) * 1999-10-13 2001-04-20 Aloka Co Ltd 層境界面検出装置

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04218726A (ja) * 1990-01-18 1992-08-10 E I Du Pont De Nemours & Co 容量性液体境界面センサ
JP2000266768A (ja) * 1999-03-18 2000-09-29 Hitachi Ltd 自動分析装置
JP2008046033A (ja) * 2006-08-18 2008-02-28 Sysmex Corp 検体分析装置
JP2010133925A (ja) * 2008-10-31 2010-06-17 Sysmex Corp 検体処理装置
JP2010240510A (ja) * 2009-04-01 2010-10-28 Panasonic Corp ディスペンサおよび液状材料の残量確認方法
JP2014006094A (ja) * 2012-06-22 2014-01-16 Hitachi High-Technologies Corp 検出装置および生体試料分析装置

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11263433B2 (en) 2016-10-28 2022-03-01 Beckman Coulter, Inc. Substance preparation evaluation system
EP3553528A4 (fr) * 2016-12-09 2020-07-08 Hitachi High-Tech Corporation Dispositif d'analyse d'échantillon biologique
US11085913B2 (en) 2016-12-09 2021-08-10 Hitachi High-Tech Corporation Biological sample analyzer
KR20210088663A (ko) * 2018-11-08 2021-07-14 퍼킨엘머 헬스 사이언시즈, 아이엔씨. 버피 코트 이미지 촬상을 위한 방법 및 장치
KR102504240B1 (ko) 2018-11-08 2023-02-27 퍼킨엘머 헬스 사이언시즈, 아이엔씨. 버피 코트 이미지 촬상을 위한 방법 및 장치
CN112613139A (zh) * 2020-12-14 2021-04-06 成都飞机工业（集团）有限责任公司 一种理化试样自动排样的方法
CN112613139B (zh) * 2020-12-14 2022-05-10 成都飞机工业（集团）有限责任公司 一种理化试样自动排样的方法

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