WO2015052367A1 - Composition de liège et applications de celle-ci - Google Patents

Composition de liège et applications de celle-ci Download PDF

Info

Publication number
WO2015052367A1
WO2015052367A1 PCT/ES2014/070772 ES2014070772W WO2015052367A1 WO 2015052367 A1 WO2015052367 A1 WO 2015052367A1 ES 2014070772 W ES2014070772 W ES 2014070772W WO 2015052367 A1 WO2015052367 A1 WO 2015052367A1
Authority
WO
WIPO (PCT)
Prior art keywords
cork
composition according
composition
active substance
matrix
Prior art date
Application number
PCT/ES2014/070772
Other languages
English (en)
Spanish (es)
Inventor
Jose María LINARES VIDAL
Original Assignee
Avicola De Tarragona, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avicola De Tarragona, S.A. filed Critical Avicola De Tarragona, S.A.
Publication of WO2015052367A1 publication Critical patent/WO2015052367A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05G—MIXTURES OF FERTILISERS COVERED INDIVIDUALLY BY DIFFERENT SUBCLASSES OF CLASS C05; MIXTURES OF ONE OR MORE FERTILISERS WITH MATERIALS NOT HAVING A SPECIFIC FERTILISING ACTIVITY, e.g. PESTICIDES, SOIL-CONDITIONERS, WETTING AGENTS; FERTILISERS CHARACTERISED BY THEIR FORM
    • C05G5/00—Fertilisers characterised by their form
    • C05G5/40—Fertilisers incorporated into a matrix

Definitions

  • the present invention relates to compositions for the progressive release of active substances in different media. More specifically, the object of the invention is a composition formed by a lipophilic cork matrix for the progressive release of active substances that cover the cork matrix or are absorbed therein.
  • This composition has important applications in the field of agriculture and food, particularly in aquaculture.
  • Cork is a 100% natural, completely renewable material, which comes from the bark of certain trees, the best known being the cork oak (Quercus super L.), a tree whose natural habitat is the western Mediterranean basin.
  • the cork oak is the basis of a unique ecological system in the world, contributing to the survival of many species of native fauna and flora and for the prevention of desertification in vulnerable areas, being essential to safeguard the environment.
  • the cork oak has a duration between 170 and 200 years, during this period it can be barked 15 to 18 times.
  • the cork oak forest occupies an area of 2.3 million hectares in the world, from which about 340,000 tons of cork are extracted each year.
  • the chemical composition of virgin cork is:
  • Suberine (45%), a polyester complex, is the main component of the cell wall, responsible for the elasticity of the cork; • lignin (27%), insulation compound;
  • tannins 6%
  • polyphenolic compounds responsible for color
  • cork The main basis of the functionality of the cork is in its cellular structure.
  • the interior of the cork is composed of a honeycomb of small suberine cells, filled with a gas mixture almost identical to that of air.
  • Each cubic centimeter of cork contains, on average, 40 million cells.
  • the structure and chemical composition of the cork give it a set of unique qualities:
  • cork and rubber compounds This excess material is granulated and used in a wide variety of applications such as cork and rubber compounds, general purpose agglomerates and for floor and wall coverings.
  • the cork granules are mixed with a polymeric binder and compressed under heat and pressure.
  • the variables to consider in this process are the size and fraction of cork granules in the mixture, the type of polymer and the final density. Certain items such as shoe soles, memory cards, panels, etc., are produced in this way.
  • cork properties are involved, such as the high coefficient of friction and the damping capacity, in the case of soles, or its ability to absorb energy during an impact, in the case of mechanical insulation applications. (Silva et al. "Cork: properties, capabilites and applications. International Materials Reviews. 2005. Vol 50. No. 6).
  • cork In addition, its internal structure, as well as the properties of certain types of cork, serve to be used as an absorbent against possible spills of liquids, fats or oils (PT103492).
  • cork is currently produced with lipophilic and hydrophobic properties, or with lipophilic and hydrophilic properties depending on its industrial manufacturing process.
  • the cork has acquired importance in its use as an absorbent of pollutants, thanks above all to the advantages that derive from its low cost and its biodegradable nature.
  • There are studies that cite the advantages of cork for bioabsorption of heavy metals such as Cu (II), Zn (ll), Cr (IV) and Ni (ll) (Silva et al).
  • the lipophilic properties of the cork ensure optimal behavior in contact with fats.
  • cork is achieved by heating it, subjecting it to water vapor and temperature processes, until the gas contained in its alveoli migrates and leaves them empty (WO2010047610). In some cases, it can also be subjected to microwaves to increase its volume and therefore its absorption capacity
  • Cork is usually used in grainy presentation. This presentation consists of an irregular primary structure, depending on its size and secondary structure formed by an ordered sequence of alveoli with approximate sizes of 30 microns, with an arrangement similar to a panel of bees. It is the cavities of these alveoli that absorb and house the aforementioned liquids. Still full of liquid or grease, the cork still maintains its floating property.
  • compositions based on the use of lipophilic cork that include at least one active substance.
  • the cork in this case can act as an absorbent matrix of said active substance or be totally or partially impregnated by it.
  • the properties of the cork allow the progressive release of the absorbed substances, which, together with other characteristics of the cork, has allowed the authors of the present invention to develop surprising new applications of this material, based mainly on their hydrophobic, floating and / or progressive release of the cork, a consequence of the specific use of its honeycomb structure.
  • Industrial aquaculture has been developed and industrialized to meet the food demand of the world's population. In the field of aquaculture, and specifically in the use of products for the conservation of water quality, its pH, or food for nutritional or pharmacological purposes, there is interest in products capable of absorbing and generating a progressive or orderly release of the substances absorbed inside its particles. The alveolar structure of the cork gives these properties.
  • buoyancy is an important parameter, which the cork provides, and which is a novelty because there is no history of its use for this purpose. Its nature makes cork an ecological and environmentally friendly product, being an especially interesting product for use in this field of fish feeding.
  • cork has been used as an absorbent support for oral use and progressive or orderly release of Nutrients or drugs
  • the vegetable and natural composition of the cork guarantees its safety, in addition to the fact that throughout the digestive process, its structure of insoluble vegetable fiber remains intact, acting as an ideal support, which will be eliminated with the feces after crossing the entire intestinal transit.
  • Figure 1 ESEM image (x60) of a matrix of granulated cork supporting a load of 50% of its weight of soy lecithin.
  • Figure 9. ESEM image (x535) of a matrix of lipophilic-hydrophobic granulated cork.
  • composition for the progressive release of active substances comprising a lipophilic cork matrix and at least one active substance, is contemplated.
  • the progressive release of the active substance is produced by the orderly arrangement of consecutive layers of the cork alveoli, so that it is carried out in an orderly manner from the outer layers of the alveoli towards the cork core.
  • the release of active substances can be carried out in liquid media (for example in the dispersion of medicines in aquariums, phytosanitary products in the field, etc.); biological systems (for example in the stomach of animals) and / or in the air (suitable for volatile substances, for example insecticides).
  • the active substances can be incorporated into the composition of the invention in the form of liquid or solubilized acids (organic and inorganic), aqueous and / or oily liquids, being able to be selected, preferably from nutrients (eg fats or vegetable or animal oils , soy lecithin, fish oil, zinc oxide solubilized in glycerin, etc.), nutraceuticals, drugs (eg fat-soluble active ingredients, such as lidocaine, vitamin A, vitamin D, vitamin E, vitamin K, etc.), insecticides (eg a mixture of specific essential oils such as clove, lemon, pine, orange; pyrethrins and their synthetic derivatives, which are fat soluble, supported on a hydrogenated fat or on any oil, etc.), fertilizers (e.g. zinc oxide solubilized in glycerin) and mixtures thereof.
  • nutrients eg fats or vegetable or animal oils , soy lecithin, fish oil, zinc oxide solubilized in glycerin, etc.
  • the active substance (s) impregnate totally or partially the surface of the cork matrix.
  • the active substance (s) are absorbed by the cork matrix, occupying the space formed by the alveoli of the material.
  • the cork acts as an absorbent support for said substances.
  • the active substances can be absorbed directly into the cork matrix (as is the case with natural vitamin E or essential oils). However, in other cases the active substance is absorbed by the cork through the use of an intermediate support (eg water, acid, oil, alcohol, such as glycerin, etc.).
  • an intermediate support eg water, acid, oil, alcohol, such as glycerin, etc.
  • aqueous active substances water alone fails to penetrate inside the hydrophobic cork, so, in these cases, it is possible to use organic or inorganic acids, for use in food, as intermediate support , such as butyric acid.
  • organic or inorganic acids for use in food, as intermediate support , such as butyric acid.
  • the lipophilic and hydrophobic cork perfectly absorbs this substance, so using a mixture of Butyric acid with Water, for example in a 50/50 ratio, all the water in the mixture will be absorbed by the cork.
  • the active substances are preferably oils and / or liquid fats.
  • they are solid fats it is possible to heat them until liquefied, then adding it to the cork in order to absorb said fat. Once absorbed the product can be refrigerated with C0 2 .
  • the presentation of the product can be in ground, micronized or granulated form.
  • the presentation of the product is in the form of cork granules, from 0.01 mm to 20 mm.
  • the vegetable and natural composition of the cork guarantees its safety, in addition to the fact that throughout the digestive process, its structure of insoluble vegetable fiber remains intact, acting as an ideal support, which will be eliminated with the feces after going through the entire intestinal transit.
  • cork is a natural source of dietary fiber, more specifically insoluble fiber, its contribution in the diet facilitates digestive transit, intestinal motility, as well as the transport of water to ensure adequate stool volume and avoid problems with constipation.
  • Cork is a fiber that is not digested but can be used in animal feed as a source of fiber and as a support for nutrients, drugs, vitamins or other substances to enrich, complete or supplement the ration.
  • the contribution of the cork replaces and compensates the fiber needs in the food formulas, also providing the composition of the invention with greater floating capacity, and thus allowing to regulate the desired buoyancy.
  • the active substances when absorbed by the cork matrix occupy, depending on the amount added, a greater or lesser number of the alveoli that make up the cork matrix so, after taking into account the different ingredients that make up the composition, The percentage contributed by active substances, which determines the percentage of cork present in the composition, will determine the greater or lesser buoyancy of the granule or pellet, thus being able to adapt it to the species to which it is intended.
  • the present invention contemplates the possibility that the cork granules with the absorbed product can be coated with a retarding product so that it does not release the absorbed substances (nutrients, drugs, etc.) before reaching the intestine .
  • the cork matrix is sprayed with molten hydrogenated grease, or other protective agents to give an outer covering, and once solidified at room temperature, allows, after ingestion, to preserve the content of the Cork matrix of gastric acids, to be subsequently released by the action of pancreatic and intestinal lipases, or intestinal pH from the intestine.
  • composition of the invention in agriculture is contemplated.
  • insecticides or fertilizers are used as active substances.
  • compositions are very useful for the use of fertilizers that must have specific properties, for example, the cultivation of algae, rice, etc.
  • the hydrophobicity properties, the slow or orderly release of active or nutritional ingredients, or the buoyancy of the cork favor this application.
  • lipophilic and hyphrophobic cork prevents deterioration of the composition by preventing the penetration of irrigation water or water rain in the cork.
  • insecticidal compositions their use is favored by the progressive and orderly release properties of active ingredients.
  • lipophilic and hyphrophobic cork prevents the deterioration of the active substances contained in the composition by protecting it from environmental humidity, irrigation waters or rains.
  • An example of an insecticidal composition is that formed by essential oils contained in cork granules.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Animal Husbandry (AREA)
  • Organic Chemistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Nutrition Science (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fertilizers (AREA)

Abstract

La présente invention concerne une composition permettant la libération contrôlée de substances actives, qui comprend une matrice de liège lipophile et au moins une substance active, laquelle substance active imprègne complètement ou partiellement la matrice de liège ou bien est absorbée par celle-ci. Cette invention porte également sur l'emploi de cette composition en vue de son utilisation par voie orale, pour l'administration de nutriments et/ou de substances pharmaceutiques dans l'alimentation humaine et animale et pour son emploi dans l'agriculture.
PCT/ES2014/070772 2013-10-11 2014-10-10 Composition de liège et applications de celle-ci WO2015052367A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES201331498A ES2535453B1 (es) 2013-10-11 2013-10-11 Composición de corcho y aplicaciones de la misma.
ESP201331498 2013-10-11

Publications (1)

Publication Number Publication Date
WO2015052367A1 true WO2015052367A1 (fr) 2015-04-16

Family

ID=52812550

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2014/070772 WO2015052367A1 (fr) 2013-10-11 2014-10-10 Composition de liège et applications de celle-ci

Country Status (2)

Country Link
ES (1) ES2535453B1 (fr)
WO (1) WO2015052367A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991017741A1 (fr) * 1990-05-18 1991-11-28 Peterson Ray L Composition et substrat de degradatioin de substances residuaires et de mauvaises odeurs
CN2197055Y (zh) * 1994-08-02 1995-05-17 贺丰杰 药物海绵栓
JPH11199359A (ja) * 1998-01-07 1999-07-27 Uchiyama Mfg Corp 肥料含浸コルク粒
CN102153413A (zh) * 2011-05-06 2011-08-17 广西崇左市湘桂糖业有限公司 一种有机无机复合肥料及其制备方法
EP2570034A1 (fr) * 2011-09-15 2013-03-20 Landwirtschaftliches Zentrum für Rinderhaltung, Grünlandwirtschaft, Milchwirtschaft, Wild und Fischerei Baden-Württemberg Alimentation pour animaux aquacoles

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991017741A1 (fr) * 1990-05-18 1991-11-28 Peterson Ray L Composition et substrat de degradatioin de substances residuaires et de mauvaises odeurs
CN2197055Y (zh) * 1994-08-02 1995-05-17 贺丰杰 药物海绵栓
JPH11199359A (ja) * 1998-01-07 1999-07-27 Uchiyama Mfg Corp 肥料含浸コルク粒
CN102153413A (zh) * 2011-05-06 2011-08-17 广西崇左市湘桂糖业有限公司 一种有机无机复合肥料及其制备方法
EP2570034A1 (fr) * 2011-09-15 2013-03-20 Landwirtschaftliches Zentrum für Rinderhaltung, Grünlandwirtschaft, Milchwirtschaft, Wild und Fischerei Baden-Württemberg Alimentation pour animaux aquacoles

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 199942, 27 October 2014 Derwent World Patents Index; Class C04 *
DATABASE WPI Week 201181, 27 October 2014 Derwent World Patents Index; Class C04 *

Also Published As

Publication number Publication date
ES2535453B1 (es) 2016-02-23
ES2535453A1 (es) 2015-05-11

Similar Documents

Publication Publication Date Title
US20040086541A1 (en) Biodegradable sorbents
CN101297645B (zh) 印楝油微胶囊及其制备方法
US20170320573A1 (en) Method and system for delivering biodegradable shelled portions
CN103535383A (zh) 一种含天然菌物高效防治松墨天牛的生物农药及用途
KR101659173B1 (ko) 고흡수성 수분흡수제와 그 제조 방법
ES2535453B1 (es) Composición de corcho y aplicaciones de la misma.
KR101305384B1 (ko) 피톤치드 겔 조성물의 제조방법 및 상기 방법에 의해 제조된 항균효과와 공기정화 기능이 구비된 피톤치드 겔 조성물
KR20120106322A (ko) 다기능 젤라틴 캡슐 및 그 제조 방법
CN100397993C (zh) 印楝油微胶囊及其制备方法
ES2971707T3 (es) Un desodorizante aglomerante que comprende un núcleo de carbón activado
Chen et al. Diet and effects of Sanford’s brown lemur (Eulemur sanfordi, Archbold 1932) gut-passage on the germination of plant species in Amber forest, Madagascar
JP2016037494A (ja) 忌避剤及び忌避製品
CN104336016A (zh) 一种灭鼠药
CA3162023A1 (fr) Formulation de plastique a liberation prolongee
ES2733244T3 (es) Procedimiento de elaboración de un material compuesto no poroso hidro- y/o lipo-absorbente de composiciones activas líquidas
ES2338823T3 (es) Producto compuesto apto para difundir un agente activo.
KR101077889B1 (ko) 문화재용 고흡습제 및 그 제조방법
US20170291706A1 (en) Method and system for delivering biodegradable shelled portions
CN105638741A (zh) 一种苏云金芽孢杆菌缓释漂浮片剂及其制备方法
CN203097360U (zh) 一种中药饮片养护存储装置
CN108329010B (zh) 一种适用于草地的空心多孔隙球型水分调节器
CN105444626B (zh) 一种用于植被区域的防雹弹
WO2021212245A1 (fr) Substrat et sable écologiques à base d'algues marines pour animaux, animaux de compagnie et petits animaux
KR200334505Y1 (ko) 숯과 황토를 이용한 탈취제
CN207683074U (zh) 一种防水防火驱虫合成革

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 14851626

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 14851626

Country of ref document: EP

Kind code of ref document: A1