WO2015025902A1 - Nasal brain function regulator and method for nasally regulating brain function - Google Patents

Abstract

Provided is a nasal brain function regulator which acts on specific places in a subject's brain using the sense of smell to stimulate or suppress activity of the specific places in the brain, the regulator comprising, as an active ingredient, a lemongrass extract extracted by an extraction method which includes a step of extraction of stirring lemongrass with an impeller while crushing the same, and applying heat from outside and reducing pressure during the crushing and stirring. Also provided is a method for nasally regulating the brain function by administering the nasal brain function regulator to a subject to act on specific places in the subject's brain so as to stimulate or suppress activity of the specific places in the brain.

Description

Nasal brain function regulator and method for regulating brain function nasally

The present invention relates to a nasal brain function regulator comprising, as an active ingredient, an extract extracted from a specific plant, and the nasal brain function regulator is administered to give a brain function nasally. It relates to the method of adjustment.

It is known that extracts extracted from plants such as fragrances and essential oils can be used as symptomatic treatment for psychiatric symptoms.
However, its use is often only symptomatic treatment, and there are many unknowns about its effects, and it has been unclear whether or not the benefits can be obtained by using a prior examination or the like. Moreover, the individual difference of this effect is also strong, and it was not clear whether it was effective for everyone or always.

However, in Japan, even if such a situation is subtracted, aromatherapy using essential oil for medical treatment is being carried out.
Patent Document 1 describes a preventive or therapeutic agent for senile dementia containing a β-secretase inhibitor containing an essential oil component having a specific functional group. Such essential oil components include clove oil and tea tree. It is said to be contained in oil.

Further, Patent Document 2 describes an olfactory function improving agent containing sage essential oil as an active ingredient, and is said to be effective when administered to a patient with dementia.

Thus, it is thought that essential oil and a fragrance | flavor have various effect | actions, when the fragrance is sensorially received by the human body.
However, it is not clear whether the effect is effective for anyone or always, and the method in which the scent component is used more effectively has not been sufficiently studied.
In addition, it is not sufficient to search for scent components, study the effectiveness of scent components, determine effective nasal doses of scent components, and activate any function in any location of the brain, suppress enhancement Also, evaluation methods such as adjustment were not sufficient, and further study was necessary.

Under such circumstances, little is known about nasal brain function regulators supported by effective evaluation methods for brain function activation, hyperactivity suppression, adjustment, etc., and there is no clear support. Some nasal brain function regulators have been desired.

JP 2010-254607 A JP 2013-014537 A

The present invention has been made in view of the above-mentioned background art, and its problem is to search for unknown actions of “substances extracted from plants” such as essential oils, fragrances, and extract liquids, and in particular, various effects on brain function. To provide a novel “nasal brain function regulator containing an extract extracted from a plant as an active ingredient” capable of effectively regulating brain function, and using the same The object is to provide a method for adjusting brain function nasally.

As a result of intensive studies to solve the above problems, the present inventor has found that an extract from a specific plant can perform local adjustment of the brain with reproducibility. Thus, the present invention has been completed.
The present invention, which contains an extract extracted from a “specific plant” as an active ingredient, has been found for the first time a remarkable effect that is extremely effective in the medical field, etc. It was newly made as a “regulator”.

That is, the present invention is a transnasal brain function regulator that acts on a specific location of the subject's brain using the sense of smell and activates or suppresses the activity of the specific location of the brain, Contains lemongrass extract extracted as an active ingredient by an extraction method that involves stirring the lemongrass with a stirring blade and extracting it under reduced pressure while applying heat from the outside under crushing and stirring. It is a nasal brain function regulator characterized by being.
Hereinafter, the “extraction method having a step of stirring while crushing with a stirring blade and extracting under reduced pressure while applying heat from the outside under crushing and stirring” is simply abbreviated as “low-temperature vacuum extraction method”.

In addition, the present invention provides the above-mentioned nasal brain function regulator to a specific place in the patient's brain by administering it to a patient having a psychiatric disorder or systemic disorder that exhibits psychiatric symptoms, It is a method for adjusting brain function nasally, characterized by activating or suppressing activity at a specific location in the brain.

In addition, the present invention provides the above-mentioned nasal brain function regulator to a specific location in the brain of the patient by administering it to a patient having an organic brain degeneration. It is a method of adjusting brain function nasally characterized by activating or suppressing the activity of a place.

In addition, the present invention provides the above-mentioned nasal brain function regulator to a specific place in the brain of a person by administering it to a person who does not have a disease, and thereby the activity of the specific place in the brain is controlled. It is a method for adjusting brain function nasally characterized by activation or suppression.

According to the present invention, the above-mentioned problems and the above-mentioned problems are solved, and brain function activation, brain activity activation, including the activity location of the brain, the degree of the activity, etc. An effective nasal brain function regulator that is clearly supported by the evaluation method can be provided.
In addition, it is possible to provide an effective nasal cerebral function regulator whose brain activation location and degree, inhibition suppression location and degree, etc. are clearly clarified.
In addition, it is possible to provide a nasal brain function regulator having a specific effect for a person having a specific disease, a person who wants to adjust the activity of a specific brain function, or the like.

The nasal brain function regulator of the present invention can stimulate the brain and regulate blood flow in a specific part of the brain, which can be performed in a short-term or continuously.
The nasal cerebral function regulator of the present invention includes blood flow volume, blood volume, “volume of blood containing oxygen-bound hemoglobin”, “blood containing oxygen-bound hemoglobin, The ratio of the amount of blood containing hemoglobin to which no oxygen is bound can be adjusted.

In addition, since the main action is obtained by the scent, it is possible to provide a nasal brain function regulator with less burden and side effects on the subject.
Therefore, the nasal brain function regulator of the present invention can be used not only as a pharmaceutical product, but also as a prophylactic agent for people who do not have a disease, cosmetics, aromatherapy products, fragrances, care products, etc. It can also be used effectively for further adjustment of brain function activity of healthy subjects.
There is no drug other than the nasal brain function regulator of the present invention that can selectively adjust the brain locally by a simple method.

In addition, the nasal brain function regulator of the present invention may be administered to provide data for evaluating cranial nerve disease by a specific technique, or to provide data for regulating brain function activity. it can.
If such a technique is used, it is also effective for determination of dose, determination of administration time, determination of administration method, and the like.
Since the amount of brain activity of the subject can be improved, the use of the nasal brain function regulator of the present invention leads to improvement of cognitive functions such as improvement of work amount.

The nasal brain function-regulating agent of the present invention reduces the risk of suffering from patients with psychiatric or systemic diseases that exhibit mental symptoms such as dementia, patients with organic brain degeneration, or those who do not have the disease. It can be used effectively for people who want to have it, and for healthy people who want to adjust their brain function activities.

In addition, when the method for adjusting brain function nasally according to the present invention is used, the subject (for example, a patient having a mental disorder or systemic disorder exhibiting psychiatric symptoms, a patient exhibiting organic brain degeneration, or a disorder) The activity of a brain function can be adjusted by activating or suppressing the activity of a specific place in the brain of a person who does not have ().

In addition, the present invention can treat cranial nerve diseases or adjust the activity of brain function, and by using the method of providing the data of the present invention, determination of dosage, determination of timing of administration, administration method It is also effective in determining
Since it is possible to improve the amount of brain activity, the use of the present invention can improve cognitive functions such as an improvement in the amount of work.

It is the schematic which shows one form of the apparatus used for the extraction process in this invention. It is an expanded sectional view which shows one form of the container of the apparatus used for the extraction process in this invention. It is a perspective view which shows one form of a structure of the stirring blade in the container of the apparatus used for the extraction process in this invention. It is the figure by the near infrared spectroscopy which shows activation of the activity of the brain when the nasal brain function regulator containing the extract from chamomile as an active ingredient is administered. Indicates activation). (A) Head right side, (b) Head left side, (c) Head front It is the figure by the near infrared spectroscopy which shows the activation of the activity of the brain when the nasal brain function regulator containing the extract from the grapefruit as an active ingredient is administered. Indicates activation). (A) Head right side, (b) Head left side, (c) Head front It is the figure by the near infrared spectroscopy which shows the activation of the brain activity when the nasal brain function regulator containing the extract from lemon grass as an active ingredient is administered. Is activated). (A) Head right side, (b) Head left side, (c) Head front It is the figure by the near infrared spectroscopy which shows the activation of the brain activity when the nasal brain function regulator containing the extract from patchouli as an active ingredient is administered. Indicates activation). (A) Head right side, (b) Head left side, (c) Head front It is the figure by the near infrared spectroscopy which shows activation of the brain activity when the nasal brain function regulator containing the extract from frankincense as an active ingredient is administered. Indicates activation). (A) Head right side, (b) Head left side, (c) Head front It is a graph which shows the result (transition of cognitive dysfunction) which administered the lemon grass extracted by the low temperature vacuum extraction method to the subject of Alzheimer's dementia.

Hereinafter, the present invention will be described, but the present invention is not limited to the following specific embodiments, and can be arbitrarily modified within the scope of the technical idea.

The present invention is a transnasal brain function regulator that acts on a specific location of a target person's brain using olfaction and activates or suppresses the activity of the specific location of the brain. A nasal brain function regulator characterized by containing an extract of lemongrass extracted by an extraction method as an active ingredient.

Since the present invention utilizes the human sense of smell, the extract extracted from lemongrass has a “scent”.
Lemongrass (C. citratus) is a perennial that belongs to the genus Cymbopogon of the Poaceae family.

Lemongrass may be extracted from any tissue of the lemongrass, and extracted from the leaves of lemongrass; stems; corolla such as petals; buds; fruits; seeds; Extracting from leaves, stems is preferred.
It is preferable to extract from “lemongrass tissue” containing a large amount of scent components. Moreover, you may extract from several structure | tissues of lemon grass.

What is used for extraction may be either sufficiently dried, not dried at all (raw as it is), or moderately dried, but is preferably sufficiently dried.
The nasal brain function regulator of the present invention contains an extract extracted from lemongrass using a low-temperature vacuum extraction method as an active ingredient. That is, lemon grass extracted by “extraction method having a step of stirring while crushing with a stirring blade and extracting under reduced pressure while applying heat from the outside under crushing and stirring” (low-temperature vacuum extraction method) Contains glass extract as an active ingredient.
Here, the form of lemongrass to be subjected to the low temperature vacuum extraction method, that is, the form before stirring the lemongrass while being crushed with a stirring blade, can be easily put into the apparatus used for the low temperature vacuum extraction method, and adapts to the apparatus. Although it will not specifically limit if it is a form, It is also preferable that it is cut | disconnected moderately. In the case of cutting, the length after cutting is preferably 0.5 cm to 20 cm, more preferably 1 cm to 15 cm, and particularly preferably 2 cm to 10 cm.

The nasal brain function regulator of the present invention acts on a specific location of a subject's brain using olfaction, and activates or suppresses the activity of the specific location of the brain. It is a regulator and contains an extract extracted from lemongrass as an active ingredient using a low-temperature vacuum extraction method.
Here, the “low-temperature vacuum extraction method” is an extraction method having a step of stirring while crushing with a stirring blade and extracting under reduced pressure while applying heat from the outside under crushing and stirring. Hereinafter, this extraction method is simply abbreviated as “low temperature vacuum extraction method”.

In the low-temperature vacuum extraction method, it is preferable to perform direct extraction by reducing the pressure at a low temperature without substantially using an extraction medium such as an organic solvent, water, or water vapor. Here, “low temperature” means a temperature lower than a general temperature when solvent extraction is performed without reducing pressure. In the case of the present invention, specifically, (the temperature of the extraction vessel is The temperature of the lemongrass is preferably 90 ° C. or less. The extraction temperature will be described in detail.

<Extraction by crushing, stirring, decompressing while applying heat from outside>
The method for producing an extract according to the present invention preferably includes a step of stirring the lemongrass once dried with crushing with a stirring blade, and extracting under reduced pressure while applying heat from the outside under crushing and stirring. .

<< Extraction device >>
FIG. 1 is a schematic view showing an embodiment of an apparatus used for an extraction step in the method for producing an extract of the present invention. As long as it is within the scope of the present invention, the nasal brain function adjusting agent of the present invention is not limited to that extracted by the apparatus shown in the figure.
1 is a container containing lemongrass, stirred while being crushed with a stirring blade, and extracted under reduced pressure while applying heat from outside while being crushed and stirred, and 2 is for cooling the steam from the container 1 It is a cooling tank.

The container 1 is composed of a lower semi-cylindrical portion 7 containing a stirring blade 6 and an upper square portion 8 formed thereon. Around the lower semi-cylindrical portion 7, there is a steam chamber 9 for applying heat to the inside of the container 1.
In the center of the lowermost part of the lower semi-cylindrical part 7, there is provided a discharge port 10 for taking out the crushed lemongrass after extraction.

An upper portion of the upper rectangular portion 8 is provided with an exhaust port 14 for sucked steam, and a pipe 16 connected to the cooling tank 2 is connected to the exhaust port 14.
At the top of the upper rectangular portion 8, a lemongrass inlet 17 is provided, and a lid 18 for closing the inlet 17 is provided.

In the method for producing an extract of the present invention, it is essential to stir lemongrass while crushing it with a stirring blade and perform extraction under crushing and stirring. By extracting in this way, extraction becomes possible as soon as a freshly crushed surface is formed, so that denaturation due to thermal decomposition or the like of effective aroma components can be prevented.
The crushing / stirring is particularly preferably performed in an extraction apparatus having a movable blade and / or a fixed blade in order to obtain the above-described effect.

For example, FIG. 3 is a perspective view showing the configuration of the stirring blade 6, and the stirring blade 6 is rotated by a motor provided outside the container 1, and is attached to the end walls 20 and 21 of the container 1. By comprising left and right end plates 22 and 23 that are rotatably supported, and vanes 24 and 25 having a substantially "<" shape, both ends of which are fixed between the ends thereof, there is no central axis. It is structured into a structure.

Reference numeral 26 denotes a plurality of fixed blades fixed to the inner surface of the lower semi-cylindrical portion 7. The portions corresponding to the fixed blades 26 in the blade bodies 24 and 25 pass through the fixed blade 26 portions of the blade bodies 24 and 25. Grooves 24a and 25a are formed, and movable blades 24b and 25b for cutting the lemongrass 31 between the fixed blades 26 are formed on both sides of the grooves.
In FIG. 3, the fixed blade 26 and the movable blades 24 b and 25 b are arranged with their positions shifted in the circumferential direction so that the meshing is sequentially performed with a shift in time, whereby the drive motor of the stirring blade 6 is driven. The momentary increase in power is prevented.

As shown in FIG. 2, there is an inclined surface 30 at the upper part of one side of the lower semi-cylindrical part 7 so that the lemongrass 31 placed thereon falls smoothly.
32 is a vacuum gauge for measuring the degree of vacuum in the container 1, and 33 and 34 are thermometers, which measure the pressure (decompression degree) and temperature in the container in the extraction process, and the temperature of the lemongrass during extraction. Is provided for indirectly measuring, and is provided for determining the start and end of extraction.

<< Extraction process >>
The operation / operation of this vacuum drying apparatus is performed as follows, for example.
First, at the start of work, the cooling tank 2 is filled with cooling water. Next, lemongrass is introduced into the container 1 from the inlet 17 and the lid 18 is closed. The stirring blade 6 is rotated in the direction of the arrow R in FIGS. 1 to 3, and the lemon grass is crushed small between the movable blades 24b and 25b and the fixed blade 26 while stirring the lemon grass in the container 1. To do.

Extraction while crushing lemongrass enables extraction from a fresh crushing surface and prevents denaturation of aroma components.

Simultaneously with the stirring and crushing, heat is applied from the outside by supplying heating steam into the steam chamber 9. Heat applied to the container 1 is transmitted to the lemongrass, and the lemongrass 31 is agitated by the agitating blades 6 so that the extraction is promoted. This extraction is further promoted by the lemongrass 31 being crushed and reduced by the movable blades 24b, 25b and the fixed blade 26.
At that time, the temperature and amount of the heating steam fed into the steam chamber 9 are adjusted so that the temperature of the lemongrass falls within a preferable range described later.

By sucking with a decompression device 46 such as an ejector or a vacuum pump, the gas in the container 1, that is, the vapor and air of the extract, is sucked through the pipe 16 and is contained in the lemongrass in the container 1. Vapor and water evaporation begins.
At that time, the amount of suction and the suction force with the decompression device 46 are adjusted so that the pressure (degree of decompression) at the time of extraction is in a preferable range described later.

“Vapor of the extract contained in the lemongrass” and “water vapor” in the container 1 are sucked through the pipe 16, introduced and liquefied into the cooling tank 2, and collected in the recovery tank 41 as a recovered liquid. .

When the recovered liquid (oil layer 50 and aqueous layer 51) is stored in the recovery tank 41 to a predetermined amount, the suction by the decompression device 46 is stopped, the valve 45 is closed, and the valve 49 is opened to recover the recovered liquid. The recovered liquid may be allowed to stand and be separated, and the oil layer 50 and the aqueous layer 51 may be recovered as extract liquids.
It is preferable to select whether to use the extract of the oil layer 50 or the extract of the aqueous layer 51 according to the application of the nasal brain function regulator of the present invention.
Moreover, when there is almost no oil layer or there are many active ingredients in an aqueous layer (aqueous phase), it is preferable to use an aqueous layer (aqueous phase), and there is almost no aqueous layer or an active ingredient is an oil layer. In the case of a large amount in (oil phase), it is preferable to use an oil layer (oil phase). Moreover, it is preferable to select the layer (phase) having more medicinal components according to the application.

In the present invention, it is suitable for atomization using a diffuser (aroma diffuser) which is a suitable device (high diffuser compatibility), blood flow in a specific place in the brain, “oxygen binding For adjusting the amount (ratio) of “blood containing hemoglobin” and adjusting the function of the brain, the content ratio of the alcohol component being higher than the aldehyde component (see Example 3), etc. It is particularly preferred to use an aqueous layer (aqueous phase, aqueous fraction).

<< Extraction conditions >>
In the method for producing the extract of the present invention, the temperature of the extraction is not particularly limited, but it is preferable that the lemongrass is maintained at a temperature of 55 ° C. or lower. More preferably, the extraction is performed such that lemongrass maintains a temperature of 20 ° C. or higher and 50 ° C. or lower, particularly preferably 25 ° C. or higher and 45 ° C. or lower, and more preferably 30 ° C. or higher and 40 ° C. or lower. It is below ℃.

When the lower limit is within the above range, the extraction time can be shortened, so that the decomposition and loss of the aroma components are suppressed, and there is no unnecessary time loss, which is economical. Moreover, a fragrance component can fully be extracted.
In the method for producing an extract according to the present invention, lemon grass is stirred while being crushed with a stirring blade, and extraction is performed with the crushing and stirring, so that extraction can be quickly performed when a fresh crushed surface is formed. However, when the lower limit is within the above range, the effect of suppressing the decomposition and loss of the fragrance component is more synergistic.
On the other hand, when the upper limit is within the above range, the active ingredient can be prevented from being denatured by heat, and the aromatic component can be sufficiently extracted while suppressing decomposition of the aromatic component. Moreover, unnecessary components are not extracted.

In the method for producing an extract of the present invention, the degree of decompression of the extraction is not particularly limited, but it is preferably performed while maintaining a pressure of 80 kPa or more lower than 101.3 kPa (1 atm). More preferably, it is carried out while maintaining a pressure of 85 kPa or lower relative to 101.3 kPa (1 atm), particularly preferably a pressure of 90 kPa or higher, and still more preferably a pressure of 95 kPa or higher.

When the pressure is the above value (the degree of decompression is the above), it becomes possible to extract the aroma component at a low temperature, so that denaturation of the active ingredient can be prevented and the decomposition of the aroma component is suppressed, Aroma components can be extracted sufficiently. Moreover, since the extraction time can be shortened, decomposition and loss of the aroma components are suppressed, and there is no unnecessary time loss, which is economical. Moreover, it becomes possible to sufficiently extract the aroma component.
In the method for producing an extract according to the present invention, lemon grass is stirred while being crushed with a stirring blade, and extraction is performed with the crushing and stirring, so that extraction can be quickly performed when a fresh crushed surface is formed. However, when the degree of decompression is as low as the above value, the effect of suppressing the decomposition and loss of the aroma component is more synergistic.

<Comparison with other extraction methods>
As described above, various methods such as a steam distillation method, a direct extraction method, a solvent extraction method, a pressing method, and a supercritical extraction method are known as the extraction method, in addition to the low-temperature vacuum extraction method of the present invention.

Of these, the steam distillation method and direct extraction method are sufficient to extract scents that are effective for adjusting brain function because the aroma components are denatured due to the high temperature heating of lemongrass and the aroma components are dissipated. It was not obtained.
Further, in the solvent extraction method, it is difficult to extract a water-soluble component, the solvent remains in the extract, and the aromatic component may be removed when the solvent is removed.
Even in the squeezing method, the oily component used as the extraction solvent remains in the extract, and it is sometimes impossible to remove the oily component.
The supercritical extraction method has problems such as lack of an appropriate extraction solvent and high pressure because it requires high-pressure equipment.
In addition, there is a case where an effective aroma component for adjusting brain function cannot be efficiently extracted by a method of extracting lemon grass after crushing and stirring instead of crushing and stirring lemon grass. In a method of extracting by heating / depressurizing instead of crushing / stirring as in a normal decompression extraction method or the like, an effective aroma component may not be extracted in order to adjust brain function.

In addition, the above-mentioned other extraction methods, including the usual vacuum extraction method of extracting lemongrass by heating and decompressing it “not while crushing”, have various components contained in the tissues and cells of lemongrass. However, since it flows out together with the fragrance component, the fragrance component may not be extracted efficiently in order to adjust the brain function.
In addition, when taking out a fragrance component together with moisture from lemongrass, other components contained in the lemongrass flow out together with the fragrance component, but other components come into contact with the fragrance component in water. In some cases, the fragrance component was modified.

In addition, for example, as shown in Example 3, the aqueous phase (aqueous layer) of the extract from lemongrass has been confirmed to have a higher alcohol component content than the aldehyde component, and the extract of the present invention. According to the production method of the above (according to the low temperature vacuum extraction method), an extract containing an aroma component that could not be obtained by a conventional extraction method or an aroma component of a component ratio that could not be obtained was obtained. Particularly effective as a nasal brain function regulator.

<Operation after extraction>
According to the low-temperature vacuum extraction method of the present invention, aromatic water is obtained from the aqueous fraction (aqueous layer, aqueous phase), and essential oil is obtained from the oily fraction (aqueous layer, oil phase).
In the present invention, the operation after extraction is not particularly limited, but it is preferable to separate and remove unnecessary components recovered simultaneously. For separation, decantation, liquid separation operation, or the like using the difference in specific gravity or the like is used.
The present invention also has an advantage that the extract is obtained as “aromatic water or essential oil” that does not contain components not derived from plants.

Extraction and separation of aroma components from plants other than the low-temperature vacuum extraction method include extraction using a steam distillation method and separation of the upper layer divided into two layers; Direct extraction method that separates the upper layer from the distillate components divided into two layers; Solvent extraction method that extracts using a solvent; Squeezing method that extracts by adding oily components and squeezing; Supercritical fluid that extracts using a supercritical fluid Examples include extraction methods.

The extract extracted from the plant may be oil-soluble or water-soluble. Moreover, although essential oil (essential oil), resin, a fragrance | flavor, etc. may be sufficient, Preferably it is a water-soluble extract.
If it is a water-soluble extract, it can be easily sprayed indoors using a general-purpose sprayer (for example, a humidifier), and the filter etc. is not contaminated. It has the effect that it is not necessary. In addition, an effect that it is effective for activation, suppression, adjustment, etc. of brain function can be obtained. In addition, a larger amount of the water-soluble extract can be recovered in one extraction step than the oil-soluble extract. In addition, it has a light odor compared to oil-soluble extracts, but it has a relatively pleasant odor intensity and is easy to use at medical sites and at home. Furthermore, it is superior to oil-soluble extracts in that containers and parts can be easily cleaned.

“Nasal brain function adjustment” refers to acting on a specific part of the subject's brain using the sense of smell and activating or suppressing the activity of that “specific part of the brain” In other words, the sensory organs are stimulated by sensing the scent, and the stimulus acts on a specific location in the brain to activate or suppress the activity at that location, or activate or suppress the excessive enhancement of the location. That means.
Activation or suppression of activity at a specific location in the brain is detected by, for example, blood flow at that location. Therefore, when the blood flow is detected, specifically, “brain function adjustment” is, for example, acting on a specific location of the brain to increase the blood flow at that location, or conversely It means reducing or balancing (for example, equalizing) a place where the blood flow is high and a place where the blood flow is low.
Brain function adjustment is quantitative and relative control of brain activity, and is reduction or treatment of reduction in brain activity caused by reduction of unnecessary increase in brain activity, decrease in blood flow in the brain, and the like.
Activation or suppression of activity at a specific location in the brain is detected by, for example, the “amount of hemoglobin bound to oxygen” or “the ratio of the amount of hemoglobin bound to oxygen to the amount of hemoglobin bound to oxygen”. Is done. Therefore, when the blood flow is detected, specifically, “brain function adjustment” refers to the amount of “blood containing hemoglobin combined with oxygen” acting on a specific place in the brain. It means increasing the ratio, conversely decreasing the blood volume or the blood ratio, and balancing (for example, making uniform) a place where the blood flow is high and a place where the blood flow is low.
Brain function adjustment is quantitative and relative control of brain activity, such as reducing unnecessary hyperactivity of the brain, reducing the amount (ratio) of the brain's “blood containing oxygen-bound hemoglobin”, etc. It is the alleviation or treatment of the resulting decrease in brain activity.
In the present invention, “the amount of hemoglobin to which oxygen is bound” or “the ratio of hemoglobin to which oxygen is bound to hemoglobin to which oxygen is not bound” may be simply abbreviated as “blood volume” or “blood flow”.

The lemongrass is known to be used for aromatherapy, but as in the present invention, it can be used for “transnasal brain function adjustment” as defined above. There are no known nasal brain function modifiers that act on specific locations in the person's brain.
The present invention newly found a remarkable effect effective for medical treatment, etc., as described above, as an “intranasal brain function regulator”, containing an extract extracted from lemongrass as an active ingredient. It was made.

The “specific location of the brain” that regulates the brain function is preferably the frontal lobe, temporal lobe, parietal lobe, occipital lobe, limbic system or frontal orbital field.
In particular, a portion where an increase in blood volume (activation of activity) and a decrease in blood volume (inhibition of activity) can be easily controlled as an image (pattern) is preferable.

The frontal lobe has a role of managing mental actions such as thinking and judgment and voluntary movement.
The association area is located between the motor area and the sensory area, and is divided into the frontal association area, the parietal association area, the temporal association area, the visual anterior area, and the marginal lobe. The frontal association area is an area ahead of the premotor area and consists of the frontal eye field, prefrontal area, orbital area, and frontal language area.

Further specific locations of the frontal lobe include the upper frontal gyrus, middle frontal gyrus, lower frontal gyrus, central previous, frontal pole, direct rotation, frontal gyrus, primary motor area, prefrontal cortex, or frontal orbital area, Or those vicinity parts are preferable.
Above all, the central previous time, frontal pole, prefrontal cortex, or frontal orbital field, or the vicinity thereof, it is easier to control the increase in blood volume (activation of activity) and the decrease in blood volume (inhibition of activity). This is particularly preferable.

Additional specific locations of the temporal lobe include upper temporal gyrus, middle temporal gyrus, lower temporal gyrus, fusiform gyrus, lateral temporal gyrus, temporal pole, primary auditory cortex, and language areas including Wernicke area Or a temporal-parietal junction part or those vicinity parts are preferable.
Among them, the upper temporal gyrus, middle temporal gyrus, lower temporal gyrus, lateral temporal gyrus, or temporal pole, or the vicinity thereof, increase blood volume (activate activity) and decrease blood volume ( It is particularly preferable in terms of easier control of activity suppression.

The further specific location of the parietal lobe is preferably the central retrorotation, the upper parietal lobe, the lower parietal lobe, the wedge front, the central paralobule, or the vicinity thereof.

As a further specific location of the occipital lobe, a wedge portion, a lingual gyrus, a occipital pole, a primary visual cortex, or a vicinity thereof is preferable.

In the frontal lobe, temporal lobe, parietal lobe, occipital lobe, limbic system or frontal orbital field, the transnasal brain function regulator of the present invention can effectively regulate blood flow and regulate brain function. Such a place is easily controlled as a pattern of near infrared spectroscopy (NIRS) when the nasal brain function regulator of the present invention is administered.
Moreover, in the above-mentioned “further specific place”, the nasal brain function regulator of the present invention can regulate the blood flow more effectively to regulate the brain function. In other words, it is easy to control as a pattern of near infrared spectroscopy (NIRS).

Further, the present invention was made by detecting the blood volume at each location of the brain by near infrared spectroscopy (NIRS: Near-Infrared Spectroscopy or fNIRS: functional Near-Infrared Spectroscopy). The “specific location of the brain” is preferably a location where blood flow is easily detected by NIRS or the like.

Near-infrared spectroscopy (NIRS), also called near-infrared light topography (“optical topography” is a registered trademark), is used to measure oxygen hemoglobin (hemoglobin combined with oxygen) and hemoglobin concentration changes. Can be detected and mapped for each location.

FIGS. 4 to 8 are diagrams by near-infrared spectroscopy showing activation of brain activity when a nasal brain function regulator containing an extract from a specific plant as an active ingredient is administered. 4 to 8, (a) shows the left frontal orbital field, (b) shows the right temporal region, and (c) shows the left temporal region.

Subjects who received each extract (a nasal cerebral function regulator containing as an active ingredient) are characterized by their respective characteristics and regions, mainly in the prefrontal cortex, temporal lobe, and parietal lobe. Shows limited adjustment action. The shades of colors in FIGS. 4 to 8 indicate that the standard value is gray, and that the closer to black, the more brain activity is suppressed, and the closer to white, the more brain activity is activated. .

Extracts from chamomile, clary sage, grapefruit, cypress, sandalwood, patchouli, frankincense, pepper, bergamot, benzoin, lemon, lemongrass, myrrh, eucalyptus and cypress all significantly increase blood volume at each brain location (Activation of activity) or a significant decrease in blood volume (inhibition of activity) could be detected.
On the other hand, extracts from plants other than the above (plants that are not specific plants) can detect an increase in brain blood volume (activation of activity) or a decrease in blood volume (inhibition of activity) within the experimental range. Or the increase (activation) width or the decrease (suppression) width was small.

4 is chamomile, FIG. 5 is grapefruit, FIG. 6 is lemongrass, FIG. 7 is patchouli, and FIG. 8 is a nasal brain function regulator containing an extract extracted from frankincense as an active ingredient. It is a figure which shows activation of the activity of the brain by a near infrared spectroscopy. 4 to 8, a significant increase (activation) or a significant decrease (suppression) of the blood volume (activity) for each brain location can be detected.

FIG. 4 shows a case where an extract extracted from chamomile was administered, and an increase (activation) of blood volume (activity) was observed in the left frontal orbital field, the right temporal region and the left temporal region.
FIG. 5 shows a case where an extract extracted from grapefruit was administered, and a strong increase in blood volume (activity) (strong activation) was observed in the entire frontal orbital area.
FIG. 6 shows the case where an extract extracted from lemongrass was administered, but a slightly strong increase in blood volume (activity) was observed (somewhat strong activation) in the entire frontal orbital area.
FIG. 7 shows a case where an extract extracted from patchouli was administered, and a strong blood volume (activity) decrease (strong suppression) was observed in the left temporal region, and a slightly strong blood volume (activity) was observed in the right temporal region. ) (A somewhat strong suppression).
FIG. 8 shows a case where an extract extracted from frankincense was administered, and a slight increase in blood volume (activity) was observed from the upper temporal gyrus to the lower temporal gyrus of the right temporal lobe. .

The transnasal brain function regulator of the present invention acts on the brain of a target person using olfaction.
In the present invention, the subject person is preferably a patient having a mental illness or systemic illness that exhibits psychiatric symptoms because the therapeutic effect is easily achieved.
In other words, the present invention allows the above-mentioned nasal brain function regulator to act on a specific place in the brain of a patient by administering it to a patient having a mental or systemic disease that exhibits psychiatric symptoms. It is also a method for adjusting brain function nasally, characterized by activating or suppressing the activity of a specific location of the brain.

In addition, it is also preferable that the subject person is a patient having organic brain degeneration because the therapeutic effect is easily achieved.
In other words, the present invention relates to the identification of the brain by administering the above-mentioned nasal brain function regulator to a patient having an organic brain degeneration, and acting on a specific location of the patient's brain. It is also a method for adjusting brain function nasally, characterized by activating or suppressing the activity of the place.

It is also preferred that the subject person is a person who does not have a disease and is administered prophylactically in order to reduce the risk of disease.
In addition, even if the subject person is a healthy person, it is also preferable that the person is a person who is administered to adjust the activity of brain function.
In other words, the present invention allows the above-mentioned nasal brain function regulator to be administered to a person who does not have a disease, so that it acts on a specific part of the person's brain, and the activity of the specific part of the brain. It is also a method of adjusting brain function nasally characterized by activating or suppressing the above.

That is, the administration subject of the nasal brain function regulator of the present invention may be a healthy subject or a subject suffering from a disease.
By using the “nasal brain function adjusting agent”, “method for adjusting brain function nasally”, and “method for providing data for evaluating cranial nerve disease” of the present invention, Effective treatment with alleviation of mental symptoms in mental disorders such as depression and depressive neurosis, and adjustment of brain activity in other organic cranial nerve diseases such as dementia Connected.

Adjusting the function of a specific location in the brain is a kind of (or included) in activating or suppressing the activity in a specific location in the brain.

Among psychiatric diseases, the target diseases include all diseases that cause anxiety and mood disorders such as depression and depressive neurosis.
Furthermore, dementia includes Alzheimer's disease, Parkinson's disease, frontotemporal dementia, Pick's disease, Lewy body disease, Huntington's disease, progressive supranuclear palsy and other degenerative dementia; Creutzfeldt-Jakob disease, Dementia associated with infections such as HIV; and the like.
Furthermore, it is used not only for these therapeutic purposes but also for preventive purposes, and is used to adjust the activity of brain functions even in healthy individuals.

Accordingly, the present invention is also a preventive and therapeutic agent for nasal mental disorders, a preventive and therapeutic agent for nasal depressive neurosis, a preventive and therapeutic agent for nasal organic brain degeneration, and a preventive treatment for nasal dementia. It is also an agent.

When the nasal brain function regulator of the present invention is administered nasally, data for evaluating cranial nerve diseases can be provided by detecting the blood volume in the brain by near infrared spectroscopy.
According to the present invention, a cerebral nerve disease as described above can be treated or prevented by nasally administering a nasal brain function regulator and detecting the blood volume of the brain by near infrared spectroscopy. Can diagnose again.

In addition, if the nasal brain function regulator of the present invention is administered intranasally, data for adjusting brain function activity is provided by detecting the blood volume of the brain by near infrared spectroscopy. it can.
ADVANTAGE OF THE INVENTION According to this invention, a nasal brain function regulator is administered nasally and the activity of a brain function can be adjusted and a diagnosis can be performed by detecting the blood volume of a brain by a near-infrared spectroscopy. .

When the nasal brain function regulator of the present invention is administered nasally, the brain function having the step of mapping as described above by detecting the blood volume at each brain location by near infrared spectroscopy. A method for determining or adjusting the activity of a person can be provided.
A method for determining or adjusting brain function activity comprising a step of detecting and mapping a blood volume at each brain location by nasal administration of a nasal brain function regulator, by near infrared spectroscopy Can provide.

The dosage of the nasal brain function regulator of the present invention can be determined by determining the amount by which the amount of brain activity changes significantly by detecting the blood volume in the brain by near infrared spectroscopy.
The dosage of the nasal brain function adjusting agent can be determined by determining the amount by which the amount of brain activity changes significantly by detecting the blood volume of the brain by near infrared spectroscopy.
For example, the dose can be determined by observing the shading of the color representing the signal intensity of the measurement image of near infrared spectroscopy (NIRS).

The present invention provides a method for providing data for treating cranial nerve disease or adjusting brain function activity, wherein a nasal brain function regulator is administered nasally, and a near infrared spectroscopy method is provided. Thus, it is also a method of providing data characterized by detecting and mapping the blood volume at each brain location.
Moreover, it is data for treating cranial nerve disease or adjusting the activity of brain function, and is also a “brain activity fluctuation map by scent” obtained by mapping as described above.
The “brain activity fluctuation map by scent” of the present invention is a patient having a psychiatric disorder or systemic disorder exhibiting psychiatric symptoms; a patient having an organic brain degeneration; It is useful for healthy people who want to do it.

The lemon grass may be used for aromatherapy. However, in general, it is not considered that aromatherapy is effective by adjusting the amount of brain activity. Also, even if it was assumed that aromatherapy was thought to act on the brain, in the case of aromatherapy, it would normally have been thought to simply stimulate parts of the brain, such as the olfactory brain and limbic system And because the details were unknown, it wasn't thought that aromatherapy would regulate brain activity and even specific locations in the brain. In that respect, the nasal brain function regulator and the aromatherapy material of the present invention are different.

The present invention, which contains an extract extracted from lemongrass as an active ingredient, as described above, works directly on a specific part of the brain to treat and prevent various diseases such as neuropsychiatric disorders. It was newly discovered as a remarkable effect effective in medical treatment including nasal and was made as a “nasal brain function regulator”.

The method of using the nasal brain function regulator of the present invention and the method of administration to the subject may be nasal, and any known method may be used. The “agent” is preferably diluted appropriately with a solvent such as water, ethanol, vegetable oil, or a mixed solvent thereof, and atomized using a diffuser (aroma diffuser).
Particularly preferred is a method of diluting with a solvent such as water or ethanol and atomizing with a diffuser from the viewpoint that the dose can be adjusted.

In addition to the method of atomizing using a diffuser, the nasal brain function regulator of the present invention is heated by the heat of a candle, light bulb, etc. and diffused in the air, paper such as tissue paper, handkerchief, etc. It is also possible to use a method of soaking in a cloth or the like and diffusing in the air, a method of mixing with water and diffusing as mist in the air, a method of diffusing in the air by vibration, or the like. It can also be used in a bath, or diluted with carrier oil and used for massage.

In addition, the “extract extracted from lemongrass” or “diluted product” soaked in felt, gauze, non-woven fabric, etc. may be sniffed by the subject or placed indoors. You may make it sniff.
Further, they may be evaporated by heating, or may be used by being attached to what they wear. Moreover, you may make them contain in any raw material of what wears them.

The dose and administration time are preferably 1 second to 3 hours at a time, more preferably 10 seconds to 60 minutes, and particularly preferably 1 minute to 10 minutes.
The administration frequency is preferably once every 3 hours to 10 days, more preferably once every 6 hours to 3 days, and particularly preferably once every 12 hours to 1 day.

In addition, it cannot be overemphasized that the administration method to the object of the nasal brain function regulator of this invention is not limited above.

The nasal brain function regulator of the present invention may contain one or more extracts from other than lemongrass. It is also preferable that the nasal brain function regulator contains an extract having an action of regulating brain function, for example, chamomile, clary sage, grapefruit, cypress, sandalwood, patchouli, frankincense, pepper, bergamot, benzoin, It is preferable to contain an extract extracted from at least one plant selected from the group consisting of lemon, myrrh, eucalyptus and marjuram.
In addition, the nasal brain function regulator of the present invention may appropriately contain other components usually used in inhalation preparations.

The nasal brain function regulator of the present invention can be used for pharmaceuticals, quasi drugs, vaporizing and sucking agents, compositions for external use, blended fragrances, cosmetics, bath preparations, fibers and the like. When used in these applications, various additives can be blended there if necessary.

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In the present invention, the action / principle that the lemongrass extract extracted by the low-temperature vacuum extraction method can adjust the brain function of a specific place of the brain by smell (by smelling the smell) is not clear. Further, the present invention is not limited to the scope of such action and principle, but the following can be considered.
In other words, the low-temperature vacuum extraction method is an “extraction method having a step of stirring while crushing with a stirring blade and extracting under reduced pressure while applying heat from the outside under crushing and stirring” and includes impurities in the extraction step. It will never be. In addition, since extraction is performed at a lower temperature compared to conventional extraction methods, it is possible to extract components that are difficult to extract by conventional extraction methods (such as heat-sensitive components and volatile components), and specific components of the brain can be extracted from these components. It is considered that the effect of the present invention appears due to the action of adjusting the brain function of the place.

Hereinafter, the present invention will be described more specifically with reference to examples and comparative examples. However, the present invention is not limited to these examples as long as the gist thereof is not exceeded.

Example 1
For normal healthy people, camomile (Matricaria recutita), clarisage (Salvia sclarea), grapefruit (Citrus paradisi), cypress (Cupressus sempervire), sandalwood (Santalum album), patchouli (Pogostemon cablin), frankincense (Boswellia carterii), pepper (Piper nigrum), bergamot (Citrus bergamia), benzoin (Styrax benzoin), lemon (Citrus limon), lemongrass (Cymbopogon citratus), myrrha (Commiphora myrrha), eucalyptus (Eucalyptus), cypress (Chamaecyparis obtusa), majuram (igan) Majorana) were extracted with sweat-like odor, garlic-like odor, propolis-like odor, city gas-like odor, and brain function changes were examined.

Extraction from each plant was performed in a preferred manner for each plant by steam distillation, pressing extraction or solvent extraction.
The obtained essential oil was used as a stock solution, and the essential oil or fragrance volatilized by the air compressor was administered to the subject by allowing it to flow into the nasal cavity of the subject for 30 seconds using a device prepared for fragrance exposure.
The apparatus is designed to allow air from a compressor to flow into a chamber containing an extract such as essential oil, and to flow the air through a gas mask worn by the subject. It is intended to be exposed to the subject.

The nasal brain function regulator was examined in 12 healthy subjects (9 males, 3 females, mean ± SD = 33.20 ± 15.19 years old) as all subjects.

Within 1 second to 15 minutes after administration, non-invasive mapping was performed on the scalp by near infrared spectroscopy using a near infrared light topography apparatus (SMARTNIRS: manufactured by Shimadzu Corporation).

As a result, blood volume (activity) in specific locations of the brain in chamomile, clariage, grapefruit, cypress, sandalwood, patchouli, frankincense, pepper, bergamot, benzoin, lemon, lemongrass, myrrh, eucalyptus, majuram and cypress ) Increase (activation) and / or blood volume (activity) decrease (suppression).

On the other hand, extracts from other plants that were evaluated (including those known for aromatherapy) and especially simple substances such as sweat-like odor, garlic-like odor, propolis-like odor, city gas-like odor, etc. In the case of a single fragrance, an increase (activation) of blood volume (activity) and / or a decrease (suppression) of blood volume (activity) was not observed or was observed in a specific place in the brain Was very little.

Figures 4-8 show the results of extracts from chamomile, grapefruit, lemongrass and patchouli.
Further, FIG. 8 shows the result of an extract from frankincense, which showed an increase or decrease in blood volume but was not significantly observed.
Thus, in addition to the presence or absence of the effects of the present invention, such as high effects, low effects, and intermediate effects, a difference in degree was also observed.
It was shown that the nasal brain function regulator of the present invention has a local brain function regulating action. The nasal brain function regulator of the present invention can adjust (increase or decrease) the blood volume (activity) in a specific location in the brain to activate or suppress the activity in a specific location in the brain. Indicated.

Example 2
Next, the harvested lemongrass was put in a dryer and dried in air at 30 to 50 ° C. for 24 hours.

The dried lemongrass was extracted in the containers shown in FIGS.
The extraction conditions were as follows.
(1) Lemongrass temperature: 30-40 ° C
(2) Set temperature in the container: 30-40 ° C
(3) Pressure: 93-97 kPa lower pressure than 101.3 kPa (1 atm) (4) Rotation speed of stirring blade (movable blade): 4 rpm (rotation / min)

Among the collected liquid collected in the collection tank 41, the liquid in the aqueous layer (aqueous phase) 51 was used as the target extract.

Example 3
The difference in the components contained in the lemongrass extract extracted by the low-temperature vacuum extraction method and the lemongrass extract extracted by the steam distillation method was compared using a gas chromatography method.
The results are shown in Table 1. In Table 1, “%” indicates “mass%”, and “RT” indicates “retention time”.

Of the four main components contained in the lemongrass extract extracted by steam distillation, 78% are aldehyde-type components (Neral and Geranial), and 12% are alcohol-type components (Nellore and Geraniol). I found out.
On the other hand, among the four main components contained in the lemongrass extract extracted by the low-temperature vacuum extraction method, the alcohol-type component is 39%, which is more contained than that extracted by the steam distillation method. I found out.
Further, it is said that the alcohol type component is safer and less toxic and irritating than the aldehyde type component, and has a sedative effect.

Example 4
We investigated the improvement of intelligence function (cognitive function) by lemongrass extract extracted by low-temperature vacuum extraction.
A commercially available ultrasonic humidifier was installed on the wall of the cafeteria in a nursing home for the elderly, and the lemongrass extract was administered to the subject using the humidifier. Nineteen residents (average age ± standard deviation; 83.2 ± 8.61 years old) in nursing care health facilities were targeted. When it was difficult to obtain informed consent from the person himself, the parent was given consent after explaining to the parent.
The administration time was about 2 hours every day for 16 weeks. GBS scale Japanese version (GBSS-J, Japanese version of senile dementia rating scale) was implemented and the subordinate items of GBSS-J were also implemented to examine the results of administration of the lemongrass extract. (Homma A, Niina R, Ishii T and Hasegawa K: Alzheimer Dis Assoc Disord 5: 40-48, (1991)).

Among the 19 subjects mentioned above, 4 patients (mean age ± standard error; 85.53 ± 3.00 years) diagnosed with mild to moderate Alzheimer-type dementia were subject to GBSS-JA (Intellectual Function Evaluation) FIG. 9 shows the result of the above. The vertical axis of the graph in FIG. 9 indicates that the larger the number, the worse the intellectual function (cognitive function) disorder.
As a result, a significant improvement in cognitive dysfunction was seen between 8 and 16 weeks after the start of the study compared to before the start of the study. This suggests that the lemongrass extract has an action of suppressing the development of cognitive impairment.

From the results of the above examples, it is a nasal brain function regulator that activates or suppresses the activity of a specific place in the brain, and an extract extracted from lemongrass by a low-temperature vacuum extraction method, particularly extraction of an aqueous phase Those containing a liquid (a water layer component) as an active ingredient have been found to be extremely useful.

The nasal brain function regulator containing an extract extracted from a specific plant of the present invention as an active ingredient is excellent in regulating the local function of the brain. It is also widely used in the fields of therapy products, fragrances, care products and cosmetics.

This application is based on Japanese Patent Application No. 2013-71088, which is a Japanese patent application filed on August 21, 2013, the entire contents of which are incorporated herein by reference and disclosed in the specification of the present invention. It is taken in.

DESCRIPTION OF SYMBOLS 1 Container 2 Cooling tank 6 Stirring blade 7 Lower semi-cylindrical part 8 Upper square part 9 Steam chamber 10 Discharge port 14 Exhaust port 16 Pipe 17 Input port 18 Lid 20 End wall 21 End wall 22 End plate 23 End plate 24 Blade body 24a Groove 24b Movable blade 25 Blade plate 25a Groove 25b Movable blade 26 Fixed blade 30 Inclined surface 31 Lemongrass 32 Vacuum gauge 33 Thermometer 34 Thermometer 41 Recovery tank 45 Valve 46 Depressurizer 49 Valve 50 Oil layer 51 Water layer R Rotating direction

Claims (11)

1. A nasal cerebral function regulator that acts on a specific part of the target person's brain using olfaction and activates or suppresses the activity of the specific part of the brain. It is characterized by containing as an active ingredient a lemongrass extract extracted by an extraction method having a step of stirring while crushing and extracting under reduced pressure while applying heat from the outside under crushing and stirring. Nasal brain function regulator.
2. The nasal cerebral function regulator according to claim 1, wherein the extraction was performed while lemongrass was maintained at a temperature of 55 ° C or lower.
3. The nasal brain function regulator according to claim 1 or 2, wherein the extraction is performed while the lemongrass is maintained at a temperature of 20 ° C to 50 ° C.
4. The nasal brain function regulator according to any one of claims 1 to 3, wherein the extraction is performed while maintaining a pressure lower by 80 kPa or more than 101.3 kPa (1 atm).
5. The nasal brain function regulator according to any one of claims 1 to 4, wherein the stirring while crushing is performed in an extraction device having a movable blade and / or a fixed blade.
6. The nasal brain function regulator according to any one of claims 1 to 5, wherein the subject person is a patient having a mental illness or systemic illness that exhibits psychiatric symptoms.
7. The transnasal brain function regulator according to any one of claims 1 to 5, wherein the subject person is a patient having an organic brain degeneration.
8. The subject person is a person who does not have a disease, and is administered prophylactically to reduce the risk of suffering from the disease, or is administered to regulate the activity of brain function. The nasal brain function regulator according to claim 5.
9. The agent for regulating nasal brain function according to claim 6 is administered to a patient having a mental illness or systemic illness exhibiting a psychiatric symptom, thereby acting on a specific location of the brain of the patient, A method for adjusting brain function nasally, characterized by activating or suppressing activity in a specific place.
10. The agent for regulating nasal brain function according to claim 7 is administered to a patient having an organic brain degeneration so as to act on a specific location of the brain of the patient, thereby causing a specific location of the brain. A method of adjusting brain function nasally, characterized by activating or suppressing activity.
11. The agent for regulating nasal brain function according to claim 8 is administered to a person who does not have a disease to act on a specific part of the person's brain to activate or activate the activity of the specific part of the brain. A method of adjusting brain function transnasally, characterized by suppressing.

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