WO2018211742A1 - Mask for activating brain, and mask for preventing/treating dementia - Google Patents
Mask for activating brain, and mask for preventing/treating dementia Download PDFInfo
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- WO2018211742A1 WO2018211742A1 PCT/JP2018/001956 JP2018001956W WO2018211742A1 WO 2018211742 A1 WO2018211742 A1 WO 2018211742A1 JP 2018001956 W JP2018001956 W JP 2018001956W WO 2018211742 A1 WO2018211742 A1 WO 2018211742A1
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- mask
- lemongrass
- extraction
- brain activation
- brain
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- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
- A41D13/00—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches
- A41D13/05—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches protecting only a particular body part
- A41D13/11—Protective face masks, e.g. for surgical use, or for use in foul atmospheres
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- the present invention relates to a brain activation mask, a dementia prevention treatment mask, etc., which are impregnated with an aqueous extract extracted from lemongrass by a specific method.
- Patent Document 1 describes a preventive or therapeutic agent for senile dementia containing a ⁇ -secretase inhibitor, which is an essential oil component, and the essential oil component is included in clove oil or tea tree oil.
- Patent Document 2 describes an olfactory function improving agent containing sage essential oil as an active ingredient, and is said to be effective when administered to a patient with dementia.
- fragrances and essential oils are thought to have various effects because their scent is perceptually received by the human body, but their effects are often sensual, medical, It lacked scientific verification.
- the use of the fragrances and essential oils was vague, such as for aromatherapy, and was not limited based on evidence based on more basic medical and scientific experiments. .
- Patent Document 3 describes a high-quality aromatic component-containing extract extracted from a plant such as lavender, rosemary, lemongrass, etc. by a specific extraction method. Further, in Patent Document 4, an extract extracted from lemongrass or the like by a specific extraction method acts on a specific location in a human brain using olfaction, or activates the activity in a specific location in the brain. Inhibitory transnasal brain function modifiers are described.
- Patent Document 3 merely lists fragrant plants as extraction targets, and does not examine differences in effects among plants, and thus applicability to specific applications.
- the uses are such as aromatherapy, fragrance, cosmetics, food, medicine and the like, and the extract from a specific plant was not found to be particularly excellent for a specific use.
- Patent Document 3 mainly obtains essential oil and is characterized by being easily mixed with a fat-soluble raw material.
- Patent Document 4 describes a nasal brain function regulator that acts on or affects various brain functions using near infrared spectroscopy (NIRS), but near infrared spectroscopy (NIRS) is described. ) Measurement results only, and based on practical measurement results (evidence) directly linked to the human condition, no use (dementia prevention treatment, anti-stress, cortisol secretion suppression, appetite enhancement) For example) was not limited and could not be limited.
- NIRS near infrared spectroscopy
- any of the above patent documents has no limitation on the method of using the extract, and it is considered that the extract is mainly used after being volatilized in a space, and is not described as being used as a mask impregnated with an aqueous extract. .
- brain activation supported by medical measurements, analytical measurements, measurements directly related to humans, etc.
- a brain activator that is hardly known in natural products and has a clear scientific support, its use form, its use, and the like have been desired.
- the present invention has been made in view of the above-described background art, and its problem is to solve the above-mentioned problems, find an excellent brain activator backed by practical measurement results (evidence), and contain it
- An object of the present invention is to provide a mask for brain activation.
- the present inventor obtained an aqueous extract extracted from lemongrass by a specific method / condition as an extract from other aromatic plants in the form of a mask.
- the inventors have found that they exhibit excellent brain function activation, dementia prevention treatment effect, anti-stress effect and the like, and have completed the present invention.
- the present invention is an aqueous extract of lemongrass extracted by an extraction method having a step of crushing lemongrass with a stirring blade and extracting under reduced pressure while applying heat from the outside under crushing and stirring. It is intended to provide a brain activation mask characterized by being impregnated.
- the present invention is also a mask for preventing and treating dementia that enhances cranial nerve activity as a measure against dementia, stirring lemon grass while crushing with a stirring blade, and applying heat from the outside under the crushing and stirring.
- the present invention provides a mask for preventing and treating dementia, which is impregnated with an extract of lemongrass extracted by an extraction method having a step of extracting under reduced pressure.
- the present invention also provides a mask for preventing or treating dementia, an anti-stress mask, a cortisol secretion-suppressing mask, and an appetite-enhancing mask characterized by being the brain activation mask described above.
- extraction method having a step of stirring while crushing with a stirring blade and extracting under reduced pressure while applying heat from the outside under crushing and stirring is simply abbreviated as “low-temperature vacuum extraction method”. To do.
- NIRS near infrared spectroscopy
- the aqueous extract used for the brain activation mask of the present invention is obtained by a low-temperature vacuum extraction method, it is evaporated from a fresh crushed surface, and it is necessary to use an extraction solvent such as water or an organic solvent. Therefore, only plant-derived components (including cell water) are recovered as an aqueous liquid with high concentration and high yield.
- the extract can contain no substance derived from the extraction solvent, it can be composed only of naturally derived components including cell water, and is extremely safe and can be provided with peace of mind. Moreover, there is no extraction solvent odor.
- the lemongrass aqueous extract obtained by the low-temperature vacuum extraction method has the “component” or “component ratio” that was not found in the lemongrass extract by other general-purpose extraction methods. It is possible to provide a high-quality and novel aqueous extract derived from the origin. Moreover, the aqueous extract which does not contain a decomposition product, an external additive, etc. can be provided. In addition to not using a solvent, the low-temperature vacuum extraction method can suppress the heat applied to lemongrass, so it does not contain degradation products, etc. A high quality and novel aqueous extract can be provided.
- the lemongrass aqueous extract obtained by the low-temperature vacuum extraction method was more effective when combined with the mask form.
- lemongrass is the most excellent as an impregnation mask than other plants by sucking and extracting liquid extracts by low temperature vacuum extraction methods from a plurality of plants in the form of an impregnation mask. I have confirmed that.
- the mask is effective for a specific human brain because it is effective in a small amount and has little influence on the surroundings, unlike being volatilized in space. Therefore, the brain activation mask of the present invention is excellent in matching properties when used in, for example, facilities where there are many patients with dementia and the like.
- the present invention it has been confirmed that a large amount of “blood containing oxygen-bound hemoglobin” flows by NIRS as a brain activation mask, and cortisol is secreted in human saliva. Is confirmed to be suppressed, and it is confirmed that the rate of weight gain is large in rats. Therefore, the present invention is actually useful as a brain activation mask, anti-stress mask, cortisol secretion suppression mask, and appetite enhancement mask. Furthermore, being useful for the above-mentioned use is also useful as a mask for preventing and treating dementia.
- Example 1 it is a figure which shows the result of having measured the NIRS in the form of a mask about the extract obtained from the lemongrass.
- Comparative Example 1 it is a figure which shows the result of having carried out the NIRS measurement in the form of a mask about the extract obtained from the cherry tree.
- comparative example 2 it is a figure which shows the result of having measured the NIRS measurement in the form of the mask about the extract obtained from the lavender.
- Comparative Example 3 it is a figure which shows the result of having measured the NIRS in the form of a mask about the extract obtained from the orchid.
- 3 is a table summarizing the results of Example 1 and Comparative Examples 1, 2, and 3.
- It is a conceptual diagram which shows the principle of the function evaluation of the mask for brain activation of this invention. It is a graph which shows the change of the amount (microgram / dL) of cortisol in saliva when using the brain activation mask of this invention, ie, an anti-stress effect. It is a photograph which shows the measuring method of the appetite increase effect of the aqueous extract obtained from lemon grass. It is a graph which shows the measurement result of the change of a body weight when an aqueous extract obtained from lemongrass was made to smell a rat.
- the mask for brain activation according to the present invention is characterized by being impregnated with an aqueous extract of lemongrass.
- Extraction from lemongrass may be performed from any tissue of the lemongrass, but is preferably extracted from the leaves of lemongrass.
- what is used for extraction may be either non-dried (raw) or somewhat dried, but preferably non-dried (substantially raw) cells. It is preferable because it contains sufficient water and does not deteriorate.
- the variety of lemongrass used in the present invention is not particularly limited.
- an extraction solvent including water in order to obtain the effect of the present invention.
- an aqueous extract is mainly obtained.
- an oily component which is also referred to as an essential oil, is dissolved to be uniform as an aqueous solution, or a small amount of an oily component is separated into an upper layer or dispersed in an aqueous phase. This aqueous phase is also included.
- a small amount of oily component is separated into the upper layer, it can be used as a uniform aqueous dispersion (also referred to as “aqueous extract” in the present invention) by stirring and the like.
- the water of the aqueous extract is cell water of lemongrass. Therefore, all of the aqueous extract is derived from a natural product (plant) called lemongrass. In addition, when extracted by a low-temperature vacuum extraction method, alteration due to heat does not occur, so that it remains a natural product (plant). Further, since the cell water is extracted while stirring with a specific stirring blade, it passes through the cell membrane of lemon grass.
- cellular water refers to intracellular fluid contained in plant cells.
- the “aqueous extract of lemongrass” in the present invention is extracted by an extraction method having a step of stirring lemongrass while crushing with a stirring blade and extracting under reduced pressure while applying heat from the outside under crushing and stirring. It is essential. That is, the “lemongrass aqueous extract” in the present invention is obtained using a low-temperature vacuum extraction method.
- the “aqueous extract of lemongrass” contains an extremely large amount of active ingredients, so identifying those ingredients and identifying the active ingredients that exhibit the effects of the present invention from those ingredients Impossible or nearly impractical (there is “impossible / impractical circumstances”). Therefore, the “lemongrass aqueous extract” in the present invention has no method other than specifying by the production method (extraction method).
- the “lemongrass aqueous extract” in the present invention is agitated while crushing lemongrass with a stirring blade without adding an extraction solvent, and the temperature range of 20 ° C. to 50 ° C. is maintained under the crushing and stirring.
- the above extraction is performed by heating from the outside and cooling by evaporating heat of cell water or the like so that lemongrass maintains a temperature of 20 ° C. or higher and 50 ° C. or lower. This is preferable because the above-described effects of the present invention can be obtained.
- the form of lemongrass to be subjected to the low temperature vacuum extraction method that is, the form before stirring the lemongrass while being crushed with a stirring blade, can be easily put into the apparatus used for the low temperature vacuum extraction method, and adapts to the apparatus.
- it will not specifically limit if it is a form, It is also preferable that it is cut
- Leaf area after cutting if necessary as the area of leaves when added to a vessel is not particularly limited, preferably 0.2 cm 2 ⁇ 50 cm 2, more preferably 1cm 2 ⁇ 40cm 2, 2cm 2 ⁇ 30cm 2 is particularly preferred.
- the organic solvent, water, water vapor, carbon dioxide and other extraction media in the supercritical extraction method, etc. are not substantially used, and the solvent cannot remain by direct extraction at a low temperature under reduced pressure. Therefore, it is possible to produce an extract with only natural components, no odor of solvent remains, components are not thermally decomposed, components are not dissipated, cell water is not dissipated, and a large amount of extract is obtained. It is preferable from the point of being able to do.
- low temperature means a temperature lower than a general temperature when solvent extraction is performed without reducing pressure.
- the temperature of the extraction vessel is It is preferable that the temperature of the lemongrass itself is 20 ° C. or more and 50 ° C. or less. The extraction temperature will be described in detail later.
- FIG. 1 is a schematic view showing an embodiment of an apparatus used for an extraction step in a method for producing an aqueous extract of lemongrass.
- the container 1 contains lemongrass and is stirred while being crushed by the stirring blade 6, and maintains a temperature range of 20 ° C to 50 ° C from the outside (the temperature refers to the temperature of lemongrass) while being crushed and stirred.
- the cooling tank 2 is a device that cools the vapor coming out of the container 1.
- the container 1 is composed of a lower semi-cylindrical portion 7 containing a stirring blade 6 and an upper square portion 8 formed thereon.
- a steam chamber 9 for applying heat to the inside of the container 1.
- a discharge port 10 for taking out a crushed product of extracted lemon grass, that is, an extraction residue.
- An upper portion of the upper rectangular portion 8 is provided with an exhaust port 14 for sucked steam, and a pipe 16 connected to the cooling tank 2 is connected to the exhaust port 14.
- a lemongrass inlet 17 is provided, and a lid 18 for closing the inlet 17 is provided.
- the aqueous extract of lemongrass in the present invention can be obtained by stirring lemongrass while crushing with a stirring blade and performing extraction under crushing and stirring. In this way, if a freshly crushed surface is obtained by extraction, it becomes possible to immediately extract from the surface, so that the active ingredient can be prevented from being denatured by thermal decomposition, oxidation, etc. before being put into the extraction device. It is possible to prevent dissipation due to evaporation of the active ingredient from the crushing surface when crushing.
- the crushing / stirring is particularly preferably performed in an extraction apparatus having a movable blade and / or a fixed blade in order to obtain the above-described effect.
- FIG. 3 is a perspective view showing the configuration of the stirring blade 6, and the stirring blade 6 is rotated by a motor provided outside the container 1, and is attached to the end walls 20 and 21 of the container 1.
- a motor provided outside the container 1
- vanes 24 and 25 having a substantially " ⁇ " shape, both ends of which are fixed between the ends thereof, there is no central axis. It is structured into a structure.
- Reference numeral 26 denotes a plurality of fixed blades fixed to the inner surface of the lower semi-cylindrical portion 7.
- the portions corresponding to the fixed blades 26 in the blade bodies 24 and 25 pass through the fixed blade 26 portions of the blade bodies 24 and 25.
- Grooves 24a and 25a are formed, and movable blades 24b and 25b for cutting the lemongrass 31 between the fixed blades 26 are formed on both sides of the grooves.
- the fixed blade 26 and the movable blades 24 b and 25 b are arranged with their positions shifted in the circumferential direction so that the meshing is sequentially performed at different times. The momentary increase in power is prevented.
- the inclined surface 30 exists in the upper part of one side of the lower semi-cylindrical part 7 so that the lemongrass 31 on this may fall smoothly.
- 32 is a vacuum gauge for measuring the degree of vacuum in the container 1
- 33 and 34 are thermometers, which measure the pressure (decompression degree) and temperature in the container in the extraction process, and the lemongrass 31 at the time of extraction
- the temperature is also provided for indirectly measuring, and is provided for determining the start and end of extraction.
- the gas in the container 1 that is, the vapor and air of the extract
- a decompression device 46 such as an ejector or a vacuum pump
- the gas in the container 1 that is, the vapor and air of the extract
- cell water starts to evaporate.
- the amount of suction and the suction force with the decompression device 46 are adjusted so that the pressure (degree of decompression) at the time of extraction is in a preferable range described later. Further, the temperature range is maintained within a preferable range described later by cooling the lemongrass by the evaporation heat of water.
- the decompressor 46 is preferably an ejector using water.
- the ejector using water does not increase the degree of decompression (vacuum degree), but can increase the exhaust capacity, and thus is suitable as the decompression device 46 in the present invention. It is more preferable to use cooling water, and it is particularly preferable from the above point that the ejector is a horizontal ejector.
- the suction in the decompression device 46 is stopped, the valve 45 is closed, and the valve 49 is opened to collect the collection liquid.
- the oil layer 50 essential oil
- the oil layer 50 may be uniformly dispersed in the aqueous phase and recovered entirely.
- an aqueous layer (aqueous phase, aqueous fraction) should be used as the extraction liquid because it can be suitably used for impregnation with a mask, and is effective for activating brain functions.
- the aqueous extract can recover a larger amount in one extraction step than the oil extract (essential oil or the like).
- the odor is lighter than that of an oily extract (essential oil, etc.), but the odor is relatively comfortable and easy to use as a mask in medical settings and at home.
- oil-based extracts such as essential oils
- the temperature of the extraction is not particularly limited, but it is preferably performed so that the lemongrass itself maintains a temperature of 20 ° C. or more and 50 ° C. or less, more preferably 25 ° C. or more and 45 ° C. or less, and particularly preferably 30 It is not less than 40 ° C and not less than
- the extraction time can be shortened, so that decomposition / loss of the active ingredient is suppressed, and there is no unnecessary time loss, which is economical.
- the active ingredient can be sufficiently extracted.
- lemon grass is stirred while being crushed with a stirring blade, and extraction is performed under the crushed and stirred, so that it may be extracted as soon as a fresh crushed surface is formed.
- the lower limit of the temperature is equal to or higher than the above, the effect is further synergized with the fact that the extraction time can be shortened.
- the upper limit is less than or equal to the above, the active ingredient can be extracted while preventing the active ingredient from being modified or decomposed by heat.
- the degree of decompression of the extraction is not particularly limited, but it is preferably performed while maintaining a pressure lower than 80 kPa with respect to 101.3 kPa (1 atm). More preferably, it is carried out while maintaining a pressure of 85 kPa or lower relative to 101.3 kPa (1 atm), particularly preferably a pressure of 90 kPa or higher, and still more preferably a pressure of 95 kPa or higher. Further, it is preferably carried out while maintaining the pressure at 1 kPa [-1 atm (101.3 kPa) to ⁇ 100.3 kPa] or more and 10 kPa [1 atm (101.3 kPa) to ⁇ 91.3 kPa] or less.
- it is 2 kPa [-99.3 kPa with respect to 1 atm] or more and 9 kPa [-92.3 kPa with respect to 1 atm], and particularly preferably 3 kPa [-98.3 kPa with respect to 1 atm].
- the above is 8 kPa [ ⁇ 93.3 kPa with respect to 1 atm].
- the active ingredient can be extracted at a low temperature in consideration of the boiling point of water. Can be prevented and the active ingredient can be extracted sufficiently. Further, since the extraction time can be shortened, decomposition and loss of active ingredients are suppressed, and there is no unnecessary time loss, which is economical.
- the degree of vacuum is as low as the above value, the extraction rate is fast and the active ingredient The effect of suppressing decomposition and loss of is more synergistic.
- the above-mentioned effect of the present invention is that the extraction is performed by “heating from the outside” and “cooling by evaporating heat of cell water or the like” so that the lemongrass maintains a temperature of 20 ° C. or more and 50 ° C. or less. It is preferable to obtain.
- the volume of the container is small, there exists a vacuum pump that can lower the degree of vacuum than the above.
- the exhaust capacity needs to be large. From the practical “relationship between exhaust capacity and degree of decompression”, that is, from the point that the decompression device 46 must be present, the degree of decompression (particularly the lower limit of pressure) is preferably in the above range.
- the brain activation mask is obtained by impregnating a mask with an aqueous lemongrass extract.
- the size, material, formation form, etc. of the mask are not limited.
- the material may be natural fiber, synthetic fiber, composite or combination thereof.
- the form of formation may be any of woven fabric, knitted fabric, lace, felt, non-woven fabric, paper, breathable film, etc., or may be a laminate of a plurality of different or similar fabrics.
- a mask as a whole, may be formed by holding or adhering a carrier such as a cloth, paper, or film that supports or absorbs liquid, either outside, inside, or inside the mask.
- a carrier such as a cloth, paper, or film that supports or absorbs liquid, either outside, inside, or inside the mask.
- the extract may be impregnated into the carrier, and the carrier may be sandwiched or pasted.
- only the soaked carrier can be exchanged and used repeatedly as a whole.
- the aqueous extract of lemongrass extracted by the low-temperature vacuum extraction method is characterized by containing only components derived from lemongrass. Therefore, it is preferable to impregnate it without dilution, but impregnation after dilution is not excluded.
- the dilution solvent include water, ethanol, a mixed solvent thereof and the like.
- the place to be impregnated is not limited, and may be the entire mask, or may be the central portion or the end portion of the mask.
- the amount to be impregnated as the “lemongrass aqueous extract by low-temperature vacuum extraction method” is not limited for the entire mask, but in order to obtain the effect of the invention, 30 mg or more is preferable, and 100 mg or more is more preferable. 200 mg or more is particularly preferable.
- FIG. 5 and FIG. 6 show the principle and measurement method.
- NIRS near infrared spectroscopy
- FIG. 6 An actual measurement method is shown in FIG. In FIG. 6, A, B, and C are as follows.
- a decrease in nerve activity (brain calming) is observed in the central part of the prefrontal cortex, and a decrease in nerve activity (brain activation) is observed in other regions.
- FIGS. 6B and 6C The vertical measure (scale) on the right side of each of FIGS. 6B and 6C is red as it goes up (activated) and blue as it goes down (sedation). Since FIG. 6 is black and white and the color cannot be distinguished, an indicator line is shown in the figure. In FIGS. 7 to 10, the color is indicated by the instruction line in the same manner.
- ⁇ mask for dementia prevention treatment (1) From examples and the like, it was found that the lemongrass aqueous extract obtained by the specific extraction method of the present invention activates brain function. Therefore, the mask impregnated with the extract is useful for use as a brain activation mask, and further, dementia is improved in the direction of activating the brain, so it is useful for the prevention and treatment of dementia. In other words, the brain activation mask of the present invention is useful as a mask for preventing and treating dementia.
- the present invention is a mask for dementia prevention and treatment that enhances cranial nerve activity as a countermeasure against dementia, wherein the lemongrass is stirred while being crushed with a stirring blade, and the pressure is reduced while applying heat from the outside under the crushing and stirring. It is also a mask for the prevention and treatment of dementia, which is impregnated with a lemongrass extract extracted by an extraction method having a step of extraction. Further, preferable masks for dementia prevention and treatment (form, manufacturing method, etc.) are as described in the above-mentioned “brain activation mask”.
- Cortisol secretion suppression mask, anti-stress mask The brain activation mask of the present invention is useful as a mask for suppressing cortisol secretion. It has been confirmed that when the brain activation mask of the present invention is used, secretion of cortisol, which is a stress hormone in saliva, is actually suppressed.
- FIG. 12 shows the correlation between anti-stress and cortisol secretion in blood or saliva.
- corticotropin-releasing hormone CH
- adrenal cortex stimulating hormone ACTH
- cortisol is secreted and cortisol in blood or saliva increases. Therefore, if a decrease in cortisol in saliva is seen, it can be said that the state is the same as when there is no stress.
- the brain activation mask of the present invention When the brain activation mask of the present invention was used, cortisol in saliva was reduced (see FIG. 13). This indicates that when the lemongrass aqueous extract is aspirated, it has an anti-stress effect. Therefore, it can be said that the brain activation mask of the present invention is a cortisol secretion suppression mask, and the brain activation mask of the present invention is useful for anti-stress. In other words, the brain activation mask of the present invention can be said to be an anti-stress mask.
- the brain activation mask of the present invention is an appetite enhancement mask.
- the brain activation mask is useful as a mask for preventing and treating dementia.
- the brain activation mask of the present invention exhibits the effect of the present invention particularly when used for a dementia patient or a person who wants to prevent dementia.
- the present invention is a mask for preventing and treating dementia that enhances cranial nerve activity as a measure against dementia, stirring lemon grass while crushing with a stirring blade, and applying heat from the outside under the crushing and stirring. It is also a mask for preventing and treating dementia, which is impregnated with a lemongrass extract extracted by an extraction method having a step of extracting under reduced pressure.
- the recovered liquid collected in the recovery tank 41 was only a uniform aqueous layer (aqueous phase) 51.
- the solution was used as the target lemongrass aqueous extract.
- the oil component is considered to be dissolved in the aqueous phase.
- Preparation Example 2 Preparation of aqueous extract other than lemongrass by low temperature vacuum extraction> A cherry extract, a lavender extract, and an orchid extract were prepared in the same manner as in Preparation Example 1 except that cherry, lavender, and orchid were used instead of lemongrass.
- Preparation Example 3 ⁇ Preparation of mask> As shown in FIG. 4, the aqueous extract obtained by low-temperature vacuum extraction from lemongrass, cherry, lavender and orchid is soaked in 0.1 g filter paper as it is without being diluted with water or the like. A mask was prepared by inserting each into a general-purpose commercially available mask.
- Example 1 ⁇ Measurement of non-invasive brain activity by NIRS (measurement of brain activation and calming)>
- the masks impregnated with the lemongrass aqueous extract obtained in Preparation Example 3 were worn for 10 minutes for 10 subjects, and then NIRS measurement was performed.
- This mask is abbreviated as “lemongrass mask” in FIG.
- “no mask” was evaluated.
- the same “general-purpose commercial mask made of gauze” as used in the preparation example in which the aqueous extract was not soaked was worn for 30 minutes, and then NIRS measurement was performed.
- This mask is abbreviated as “commercially available mask” in FIG.
- FIG. 7 The results are shown in FIG. Among 10 subjects, 6 were observed to activate cranial nerve activity when wearing a lemongrass mask. In FIG. 7, the red portion is activated and the blue portion is calmed down. However, since black and white are indistinguishable from red and blue, an indication line is shown in FIG. 7. The vertical gauge on the right side is red as it goes up (activated) and blue as it goes down (sedation). The same applies to FIGS.
- Example 1 evaluation by NIRS was performed in the same manner as in Example 1 except that lemongrass was replaced with cherry. The results are shown in FIG. Among the 10 subjects, activation of cranial nerve activity was observed in 5 subjects when the cherry mask was worn.
- Example 2 evaluation by NIRS was performed in the same manner as in Example 1 except that lemongrass was replaced with lavender. The results are shown in FIG. Of the 10 subjects, 5 were observed to activate cranial nerve activity when wearing a lavender mask.
- Example 3 evaluation by NIRS was performed in the same manner as in Example 1 except that lemongrass was replaced with orchid. The results are shown in FIG. Of the 10 subjects, 7 had no change in cranial nerve activity when the run mask was worn.
- Example 2 ⁇ Measurement of salivary cortisol (measurement of anti-stress)> Masks impregnated with the aqueous extract of lemongrass obtained in Preparation Example 3 were worn for 10 subjects for 30 minutes, and the amount of cortisol in saliva was measured. This mask is abbreviated as “lemongrass mask” in FIG. As a control, “no mask” was evaluated. In addition, as a control, the same “general-purpose commercial mask made of gauze” as used in the preparation example in which the lemongrass aqueous extract was not soaked was worn for 30 minutes. This mask is abbreviated as “commercially available mask” in FIG. Cortisol in saliva was measured according to a conventional method.
- FIG. 13 shows that the amount of cortisol in saliva decreases when this lemongrass mask is worn. This indicates that the lemongrass mask is useful as a cortisol secretion suppression mask, and therefore as an anti-stress mask, and also useful as a mask for dementia prevention and treatment.
- Example 3 As shown in FIG. 14, in a breeding box containing sufficient food, the rats were allowed to smell the lemongrass aqueous extract obtained in Preparation Example 1 for 30 minutes every day for 6 days. Changes were measured. The change in body weight of each of four rats was measured, and the arithmetic mean was determined. The results are shown in FIG.
- the brain activation mask of the present invention is useful as an appetite enhancement mask, and further, since appetite is enhanced, it is also useful as a mask for dementia prevention treatment.
- the lemongrass extract impregnated in the brain activation mask of the present invention contains lemongrass cell water as it is and has a component composition different from that of conventional lemongrass extracts.
- the lemongrass extract in the present invention is derived from a plant, and it is not necessary to use an extraction solvent in the extraction process. Therefore, the brain activation mask of the present invention is useful for preventing or treating dementia, for inhibiting cortisol secretion, for anti-stress, and for promoting appetite, and is therefore widely used in the medical field, pharmaceutical field, nursing care field, etc. It is what is done.
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Abstract
Description
特許文献1には、精油成分であるβ-セクレターゼ阻害剤を含有する老人性痴呆症の予防又は治療薬が記載されており、かかる精油成分は、クローブ油やティーツリー油に含まれるとしている。
また、特許文献2には、セージ精油を有効成分として含む嗅覚機能改善剤が記載されており、認知症患者に投与すれば有効であるとされている。 It is known that fragrances and essential oils extracted from plants can be used as symptomatic treatment for psychiatric symptoms.
また、その香料や精油の用途についても、アロマセラピー用等と言った漠然としたものであり、医学的・科学的に更に基礎的な実験に基づいた証拠に基づいて用途を限定したものではなかった。 In this way, fragrances and essential oils are thought to have various effects because their scent is perceptually received by the human body, but their effects are often sensual, medical, It lacked scientific verification.
In addition, the use of the fragrances and essential oils was vague, such as for aromatherapy, and was not limited based on evidence based on more basic medical and scientific experiments. .
また、特許文献4には、レモングラス等から特定の抽出方法で抽出された抽出液が、嗅覚を利用して人の脳の特定の場所に作用して脳の特定の場所の活動を賦活又は抑制する経鼻的脳機能調整剤が記載されている。
Further, in
また、特許文献3は、主に精油を獲得するものであり、脂溶性の原料に容易に混合できることを特徴としている。 However,
また、該抽出液は、抽出溶媒由来の物質を含有させないことが可能であるため、細胞水を含め天然由来の成分だけで構成させることができ、極めて安全であり、また安心して提供ができ、また抽出溶媒臭がない。 Since the aqueous extract used for the brain activation mask of the present invention is obtained by a low-temperature vacuum extraction method, it is evaporated from a fresh crushed surface, and it is necessary to use an extraction solvent such as water or an organic solvent. Therefore, only plant-derived components (including cell water) are recovered as an aqueous liquid with high concentration and high yield.
In addition, since the extract can contain no substance derived from the extraction solvent, it can be composed only of naturally derived components including cell water, and is extremely safe and can be provided with peace of mind. Moreover, there is no extraction solvent odor.
低温真空抽出法は、溶媒を使用しないことに加え、レモングラスに加わる熱を抑制できるので、分解物等を含有しない、従来品にはなかった「成分」又は「成分比」のレモングラス由来の高品質及び新規性のある水性抽出液を提供することができる。 In addition, the lemongrass aqueous extract obtained by the low-temperature vacuum extraction method has the “component” or “component ratio” that was not found in the lemongrass extract by other general-purpose extraction methods. It is possible to provide a high-quality and novel aqueous extract derived from the origin. Moreover, the aqueous extract which does not contain a decomposition product, an external additive, etc. can be provided.
In addition to not using a solvent, the low-temperature vacuum extraction method can suppress the heat applied to lemongrass, so it does not contain degradation products, etc. A high quality and novel aqueous extract can be provided.
従って、本発明は、実際に、脳活性化用マスク、抗ストレス用マスク、コルチゾール分泌抑制用マスク、食欲増進用マスクとして有用である。更に、上記用途に有用であると言うことは、認知症予防治療用マスクとしても有用である。 In addition, in the present invention, it has been confirmed that a large amount of “blood containing oxygen-bound hemoglobin” flows by NIRS as a brain activation mask, and cortisol is secreted in human saliva. Is confirmed to be suppressed, and it is confirmed that the rate of weight gain is large in rats.
Therefore, the present invention is actually useful as a brain activation mask, anti-stress mask, cortisol secretion suppression mask, and appetite enhancement mask. Furthermore, being useful for the above-mentioned use is also useful as a mask for preventing and treating dementia.
本発明の脳活性化用マスクは、レモングラスの水性抽出液を含浸させたものであることを特徴とする。 <Lemongrass aqueous extract>
The mask for brain activation according to the present invention is characterized by being impregnated with an aqueous extract of lemongrass.
また、抽出に用いられるものは、乾燥をしないもの(生のままのもの)、ある程度乾燥したものの何れでもよいが、好ましくは、乾燥をしないもの(実質的に生のままのもの)が、細胞水を十分に含有し、変質もないために好ましい。
なお、本発明で使用されるレモングラスの品種は特に限定されない。 Extraction from lemongrass may be performed from any tissue of the lemongrass, but is preferably extracted from the leaves of lemongrass.
In addition, what is used for extraction may be either non-dried (raw) or somewhat dried, but preferably non-dried (substantially raw) cells. It is preferable because it contains sufficient water and does not deteriorate.
The variety of lemongrass used in the present invention is not particularly limited.
レモングラスを低温真空抽出法で抽出すると、主に水性抽出液が得られる。該「水性抽出液」には、精油とも言われる油性成分が溶解していて水溶液として均一になっている場合も、少量の油性成分が上層に分離していたり水相に分散していたりする場合の該水相も含まれる。少量の油性成分が上層に分離している場合は、撹拌等を行って均一な水性分散液(本発明ではこれも「水性抽出液」と言う)として使用することもできる。 In the extraction in the present invention, it is preferable not to use an extraction solvent including water in order to obtain the effect of the present invention.
When lemongrass is extracted by a low-temperature vacuum extraction method, an aqueous extract is mainly obtained. In the “aqueous extract”, an oily component, which is also referred to as an essential oil, is dissolved to be uniform as an aqueous solution, or a small amount of an oily component is separated into an upper layer or dispersed in an aqueous phase. This aqueous phase is also included. When a small amount of oily component is separated into the upper layer, it can be used as a uniform aqueous dispersion (also referred to as “aqueous extract” in the present invention) by stirring and the like.
なお、本明細書において「細胞水」とは、植物細胞に含まれる細胞内液のことである。 The water of the aqueous extract is cell water of lemongrass. Therefore, all of the aqueous extract is derived from a natural product (plant) called lemongrass. In addition, when extracted by a low-temperature vacuum extraction method, alteration due to heat does not occur, so that it remains a natural product (plant). Further, since the cell water is extracted while stirring with a specific stirring blade, it passes through the cell membrane of lemon grass.
In the present specification, “cellular water” refers to intracellular fluid contained in plant cells.
上記抽出は、外部からの加熱と、細胞水等の蒸発熱による冷却で、レモングラスが20℃以上50℃以下の温度を維持するようにしてなされるものであることが、変質がなく全て天然物であり、それによって前記した本発明の効果が得られるために好ましい。 The “lemongrass aqueous extract” in the present invention is agitated while crushing lemongrass with a stirring blade without adding an extraction solvent, and the temperature range of 20 ° C. to 50 ° C. is maintained under the crushing and stirring. Thus, it is preferable to obtain the product obtained by extraction by reducing the pressure while applying heat.
The above extraction is performed by heating from the outside and cooling by evaporating heat of cell water or the like so that lemongrass maintains a temperature of 20 ° C. or higher and 50 ° C. or lower. This is preferable because the above-described effects of the present invention can be obtained.
図1は、レモングラスの水性抽出液の製造方法において、抽出工程に用いられる装置の一形態を示す概略図である。なお、本発明の趣旨の範囲内であれば、図に示された装置で抽出されたものには限定されない。
容器1は、レモングラスを収容し、撹拌羽根6で破砕しながら撹拌し、該破砕・撹拌下に外部から20℃以上50℃以下の温度範囲(該温度はレモングラスの温度を言う)を維持しながら熱を加えつつ減圧して抽出する容器であり、冷却槽2は、容器1から出る蒸気を冷却する装置である。 << Extraction device >>
FIG. 1 is a schematic view showing an embodiment of an apparatus used for an extraction step in a method for producing an aqueous extract of lemongrass. In addition, it is not limited to what was extracted with the apparatus shown by the figure, if it is in the range of the meaning of this invention.
The
下部半円筒部7の最下部の中央には、抽出後のレモングラスの破砕物すなわち抽出残渣を取り出す排出口10が設けられている。 The
At the center of the lowermost part of the lower
前記上部角形部8の上部には、レモングラスの投入口17を設けると共に、その投入口17を塞ぐ蓋18を設けている。 An upper portion of the upper
At the top of the upper
上記破砕・撹拌は、可動刃及び/又は固定刃を備えた抽出装置内で行うことが、上記効果を得るために特に好ましい。 The aqueous extract of lemongrass in the present invention can be obtained by stirring lemongrass while crushing with a stirring blade and performing extraction under crushing and stirring. In this way, if a freshly crushed surface is obtained by extraction, it becomes possible to immediately extract from the surface, so that the active ingredient can be prevented from being denatured by thermal decomposition, oxidation, etc. before being put into the extraction device. It is possible to prevent dissipation due to evaporation of the active ingredient from the crushing surface when crushing.
The crushing / stirring is particularly preferably performed in an extraction apparatus having a movable blade and / or a fixed blade in order to obtain the above-described effect.
なお、図3では、固定刃26と可動刃24b、25bとは、噛み合いが時間をずらして順次行なわれるように、周方向に位置をずらして配設し、これにより撹拌羽根6の駆動モータの動力の瞬間的増大が起こらないようにしている。
In FIG. 3, the fixed
32は前記容器1内の真空度を計測する真空計、33、34は温度計であり、これらは抽出工程における容器内の圧力(減圧度)と温度を測定し、抽出時のレモングラス31の温度も間接的に測定するために設けられたものであり、また、抽出の開始と終了を判定するために設けられたものである。 As shown in FIG. 2, it is preferable that the
32 is a vacuum gauge for measuring the degree of vacuum in the
この真空乾燥装置の操作・動作は、例えば、下記のように行なわれる。
まず、作業開始に当り、冷却槽2に冷却水が充填される。次いで、レモングラス31を投入口17から容器1内に投入して蓋18を閉じる。そして、撹拌羽根6は、図1~図3の矢印Rの方向に回転させ、容器1内のレモングラスを撹拌しながら、可動刃24b、25bと固定刃26との間でレモングラス31を小さく破砕する。 << Extraction process >>
The operation / operation of this vacuum drying apparatus is performed as follows, for example.
First, at the start of work, the
その際、蒸気室9内に送り込む加熱用蒸気の温度や量を調節して、レモングラス31自体の温度を、後記する好ましい範囲にする。 Simultaneously with the stirring and crushing, heat is applied from the outside by supplying heating steam into the steam chamber 9. The heat applied to the
At that time, the temperature and amount of the steam for heating fed into the steam chamber 9 are adjusted so that the temperature of the
その際、減圧装置46で吸引する量や吸引力を調節して、抽出時の圧力(減圧度)を後記する好ましい範囲にする。また、水の蒸発熱によるレモングラスの冷却によって温度範囲を後記する好適範囲に維持する。 By sucking with a
At that time, the amount of suction and the suction force with the
水性抽出液は、油性抽出液(精油等)に比べて、1回の抽出工程でより多くの量を回収することができる。また、油性抽出液(精油等)に比べて匂いが薄いが、比較的心地よく感じるレベルの匂いであり、マスクとして医療現場や家庭で使い易い。更に、容器や部品等の洗浄が容易である点で、油性抽出液(精油等)より優れている。 In the present invention, an aqueous layer (aqueous phase, aqueous fraction) should be used as the extraction liquid because it can be suitably used for impregnation with a mask, and is effective for activating brain functions. Is particularly preferred.
The aqueous extract can recover a larger amount in one extraction step than the oil extract (essential oil or the like). In addition, the odor is lighter than that of an oily extract (essential oil, etc.), but the odor is relatively comfortable and easy to use as a mask in medical settings and at home. Furthermore, it is superior to oil-based extracts (such as essential oils) in that containers and parts can be easily cleaned.
上記抽出の温度は特に限定されないが、レモングラス自体が20℃以上50℃以下の温度を維持するように行うことが好ましく、より好ましくは、25℃以上45℃以下であり、特に好ましくは、30℃以上40℃以下である。 << Extraction conditions >>
The temperature of the extraction is not particularly limited, but it is preferably performed so that the lemongrass itself maintains a temperature of 20 ° C. or more and 50 ° C. or less, more preferably 25 ° C. or more and 45 ° C. or less, and particularly preferably 30 It is not less than 40 ° C and not less than
特に、下限が上記以上であると、抽出時間を短くできるので、有効成分の分解・逸失が抑制され、また、不必要な時間のロスがなく経済的である。また、有効成分を十分に抽出可能である。本発明における抗酸化剤の製造方法では、レモングラスを撹拌羽根で破砕しながら撹拌し、該破砕・撹拌下に抽出を行うので、新鮮な破砕面ができた時点で早く抽出してしまうことができるが、温度の下限が上記以上であると抽出時間を短くできることと相まって効果がより相乗される。
一方、上限が上記以下であると、有効成分の熱による変性・分解を防止しつつ有効成分を抽出できる。 If it is this range, it will be easy to show the effect of the above-mentioned this invention.
In particular, when the lower limit is not less than the above, the extraction time can be shortened, so that decomposition / loss of the active ingredient is suppressed, and there is no unnecessary time loss, which is economical. In addition, the active ingredient can be sufficiently extracted. In the method for producing an antioxidant according to the present invention, lemon grass is stirred while being crushed with a stirring blade, and extraction is performed under the crushed and stirred, so that it may be extracted as soon as a fresh crushed surface is formed. However, if the lower limit of the temperature is equal to or higher than the above, the effect is further synergized with the fact that the extraction time can be shortened.
On the other hand, when the upper limit is less than or equal to the above, the active ingredient can be extracted while preventing the active ingredient from being modified or decomposed by heat.
また、1kPa[1気圧(101.3kPa)に対して、-100.3kPa]以上10kPa[1気圧(101.3kPa)に対して、-91.3kPa]以下に維持ししつつ行うことが好ましい。より好ましくは2kPa[1気圧に対して、-99.3kPa]以上9kPa[1気圧に対して、-92.3kPa]以下であり、特に好ましくは3kPa[1気圧に対して、-98.3kPa]以上8kPa[1気圧に対して、-93.3kPa]以下である。 When the low temperature vacuum extraction method is used, the degree of decompression of the extraction is not particularly limited, but it is preferably performed while maintaining a pressure lower than 80 kPa with respect to 101.3 kPa (1 atm). More preferably, it is carried out while maintaining a pressure of 85 kPa or lower relative to 101.3 kPa (1 atm), particularly preferably a pressure of 90 kPa or higher, and still more preferably a pressure of 95 kPa or higher.
Further, it is preferably carried out while maintaining the pressure at 1 kPa [-1 atm (101.3 kPa) to −100.3 kPa] or more and 10 kPa [1 atm (101.3 kPa) to −91.3 kPa] or less. More preferably, it is 2 kPa [-99.3 kPa with respect to 1 atm] or more and 9 kPa [-92.3 kPa with respect to 1 atm], and particularly preferably 3 kPa [-98.3 kPa with respect to 1 atm]. The above is 8 kPa [−93.3 kPa with respect to 1 atm].
低温真空抽出法では、レモングラスを撹拌羽根で破砕しながら撹拌し、該破砕・撹拌下に抽出を行うので、減圧度が上記値のように低いと、抽出速度が速いという点で、有効成分の分解・逸失が抑制される効果がより相乗される。 If the pressure (especially the upper limit) is in the above range (the degree of decompression is in the above range), the active ingredient can be extracted at a low temperature in consideration of the boiling point of water. Can be prevented and the active ingredient can be extracted sufficiently. Further, since the extraction time can be shortened, decomposition and loss of active ingredients are suppressed, and there is no unnecessary time loss, which is economical.
In the low-temperature vacuum extraction method, the lemongrass is stirred while being crushed with a stirring blade, and extraction is performed with the crushed and stirred. Therefore, if the degree of vacuum is as low as the above value, the extraction rate is fast and the active ingredient The effect of suppressing decomposition and loss of is more synergistic.
容器の体積が小さいときは、減圧度を上記より低くできる真空ポンプは存在する。しかし、工業的に実施しようとすると、低温真空抽出法の場合、水の蒸発熱でレモングラスを冷却して温度範囲を前記範囲に維持するために、排気容量が大きい必要がある。現実的な「排気容量と減圧度の関係」から、すなわち減圧装置46が存在しなくてはならない等の点から、減圧度(特に圧力の下限)は上記範囲が好ましい。 The above-mentioned effect of the present invention is that the extraction is performed by “heating from the outside” and “cooling by evaporating heat of cell water or the like” so that the lemongrass maintains a temperature of 20 ° C. or more and 50 ° C. or less. It is preferable to obtain.
When the volume of the container is small, there exists a vacuum pump that can lower the degree of vacuum than the above. However, when trying to implement industrially, in the case of the low temperature vacuum extraction method, in order to cool the lemongrass with the heat of evaporation of water and maintain the temperature range within the above range, the exhaust capacity needs to be large. From the practical “relationship between exhaust capacity and degree of decompression”, that is, from the point that the
脳活性化用マスクは、マスクにレモングラスの水性抽出液を含浸させたものである。マスクの大きさ、材質、形成形態等は限定されない。材質は、天然繊維であっても、合成繊維であっても、それらの複合、組み合わせ等であってもよい。形成形態は、織物、編物、レース、フェルト、不織布、紙、通気フィルム等の何れでもよく、それらの異種又は同種の布が複数積層されたものでもよい。 <Brain activation mask>
The brain activation mask is obtained by impregnating a mask with an aqueous lemongrass extract. The size, material, formation form, etc. of the mask are not limited. The material may be natural fiber, synthetic fiber, composite or combination thereof. The form of formation may be any of woven fabric, knitted fabric, lace, felt, non-woven fabric, paper, breathable film, etc., or may be a laminate of a plurality of different or similar fabrics.
この形態の場合、染みこませた担持体だけを交換して、全体としては繰り返し使用することができる。 A mask, as a whole, may be formed by holding or adhering a carrier such as a cloth, paper, or film that supports or absorbs liquid, either outside, inside, or inside the mask. In that case, the extract may be impregnated into the carrier, and the carrier may be sandwiched or pasted.
In the case of this form, only the soaked carrier can be exchanged and used repeatedly as a whole.
マスク全体に対して、「低温真空抽出法によるレモングラスの水性抽出液」として含浸させる量は、限定はされないが、発明の前記効果を得るために、30mg以上が好ましく、100mg以上がより好ましく、200mg以上が特に好ましい。 The place to be impregnated is not limited, and may be the entire mask, or may be the central portion or the end portion of the mask.
The amount to be impregnated as the “lemongrass aqueous extract by low-temperature vacuum extraction method” is not limited for the entire mask, but in order to obtain the effect of the invention, 30 mg or more is preferable, and 100 mg or more is more preferable. 200 mg or more is particularly preferable.
本発明の脳活性化用マスクは、近赤外分光分析法(NIRS)を用いて、非侵襲的に脳活動を測定した。図5、図6にその原理と測定法を示す。
脳が活動すると、血液中の酸素化ヘモグロビンは神経細胞に酸素供給する。NIRSは、近赤外光を用いてその変化(脳表面の酸素状態変化)を捉える。
図5に示したように、頭表から近赤外光を脳内に照射し、大脳皮質で吸収・散乱を起こした光を、頭表上の光ファイバで集光・検出し、この検出光の変化で脳活動(脳活性化と脳沈静化)を測定する。 << Brain activation and brain calming by NIRS (measurement) >>
The brain activation mask of the present invention measured brain activity non-invasively using near infrared spectroscopy (NIRS). FIG. 5 and FIG. 6 show the principle and measurement method.
When the brain is active, oxygenated hemoglobin in the blood supplies oxygen to nerve cells. NIRS captures the change (change in the oxygen state of the brain surface) using near-infrared light.
As shown in FIG. 5, near-infrared light is irradiated into the brain from the head surface, and the light that has been absorbed and scattered in the cerebral cortex is collected and detected by an optical fiber on the head surface. Changes in brain activity (brain activation and brain calming) are measured.
A:本発明で用いた機器と測定(装着)方法を示す。
B:NIRSで測定した前頭葉の活動イメージ例を示す。
C:脳活動、脳内の神経活動の例、上に行くほど赤く活性の上昇(活性化)を示し、下に行くほど青く活性の低下(沈静化)を示す。
図6の例では、前頭前野中央部で神経活動の低下(脳沈静化)、それ以外の領域で神経活動の低下上昇(脳活性化)が認められている。 An actual measurement method is shown in FIG. In FIG. 6, A, B, and C are as follows.
A: Shows the equipment and measurement (wearing) method used in the present invention.
B: shows an example of frontal lobe activity image measured by NIRS.
C: Examples of brain activity and neural activity in the brain, the higher the activity, the higher the activity (activation), and the lower the activity, the lower the activity (sedation).
In the example of FIG. 6, a decrease in nerve activity (brain calming) is observed in the central part of the prefrontal cortex, and a decrease in nerve activity (brain activation) is observed in other regions.
実施例等から、本発明における特定の抽出方法で得られたレモングラスの水性抽出液は、脳機能を活性化させることが分かった。従って、該抽出液を含浸させたマスクは、脳活性化用マスクとしての用途に有用であり、更に、認知症は脳を活性化する方向で改善するので、認知症予防治療用として有用である、言い換えれば、本発明の脳活性化用マスクは、認知症予防治療用マスクとして有用である。 << mask for dementia prevention treatment (1) >>
From examples and the like, it was found that the lemongrass aqueous extract obtained by the specific extraction method of the present invention activates brain function. Therefore, the mask impregnated with the extract is useful for use as a brain activation mask, and further, dementia is improved in the direction of activating the brain, so it is useful for the prevention and treatment of dementia. In other words, the brain activation mask of the present invention is useful as a mask for preventing and treating dementia.
更に、認知症予防治療用マスクとして好ましいもの(形態、製造方法等)は、前記の「脳活性化用マスク」の部分で記載した通りである。 The present invention is a mask for dementia prevention and treatment that enhances cranial nerve activity as a countermeasure against dementia, wherein the lemongrass is stirred while being crushed with a stirring blade, and the pressure is reduced while applying heat from the outside under the crushing and stirring. It is also a mask for the prevention and treatment of dementia, which is impregnated with a lemongrass extract extracted by an extraction method having a step of extraction.
Further, preferable masks for dementia prevention and treatment (form, manufacturing method, etc.) are as described in the above-mentioned “brain activation mask”.
本発明の脳活性化用マスクは、コルチゾール分泌抑制用マスクとして有用である。本発明の脳活性化用マスクを使用すると、実際に、唾液中のストレスホルモンであるコルチゾールの分泌が抑制されることが確かめられている。 << Cortisol secretion suppression mask, anti-stress mask >>
The brain activation mask of the present invention is useful as a mask for suppressing cortisol secretion. It has been confirmed that when the brain activation mask of the present invention is used, secretion of cortisol, which is a stress hormone in saliva, is actually suppressed.
ストレスがあると視床下部から副腎皮質刺激ホルモン放出ホルモン(CRH)が下垂体前葉に作用し、下垂体前葉からは、副腎皮質刺激ホルモン(ACTH)が副腎皮質に作用する。その結果、コルチゾールが分泌され、血液又は唾液中のコルチゾールが増加する。
従って、唾液中のコルチゾールの減少が見られれば、ストレスがないときと同様の状態であると言える。 FIG. 12 shows the correlation between anti-stress and cortisol secretion in blood or saliva.
When stress is present, corticotropin-releasing hormone (CRH) acts on the anterior pituitary gland from the hypothalamus, and adrenal cortex stimulating hormone (ACTH) acts on the adrenal cortex from the anterior pituitary gland. As a result, cortisol is secreted and cortisol in blood or saliva increases.
Therefore, if a decrease in cortisol in saliva is seen, it can be said that the state is the same as when there is no stress.
従って、本発明の脳活性化用マスクは、コルチゾール分泌抑制用マスクであると言え、また、本発明の脳活性化用マスクは、抗ストレス用として有用である。言い換えると、本発明の脳活性化用マスクは、抗ストレス用マスクであるとも言える。 When the brain activation mask of the present invention was used, cortisol in saliva was reduced (see FIG. 13). This indicates that when the lemongrass aqueous extract is aspirated, it has an anti-stress effect.
Therefore, it can be said that the brain activation mask of the present invention is a cortisol secretion suppression mask, and the brain activation mask of the present invention is useful for anti-stress. In other words, the brain activation mask of the present invention can be said to be an anti-stress mask.
本発明の脳活性化用マスクをラットに対して使用すると、体重の増加速度が上昇した(図15参照)。従って、本発明の脳活性化用マスクは、食欲増進用マスクであると言える。 << Appetite enhancement mask >>
When the brain activation mask of the present invention was used on rats, the rate of weight gain increased (see FIG. 15). Therefore, it can be said that the brain activation mask of the present invention is an appetite enhancement mask.
健常人において、脳活動が亢進し脳が活性化し、コルチゾールの分泌が増えて抗ストレス効果があり、更に食欲増進が見られると言うことは、本発明のレモングラスの水性抽出液を含浸させた脳活性化用マスクが、認知症予防治療用マスクとして有用であることを示している。本発明の脳活性化用マスクは、認知症患者又は認知症を予防したい人に対して使用することが特に本発明の効果を発揮する。
従って、本発明は、認知症対策用として脳神経活動を亢進させる認知症予防治療用マスクであって、レモングラスを撹拌羽根で破砕しながら撹拌し、該破砕・撹拌下に外部から熱を加えつつ減圧して抽出する工程を有する抽出法により抽出されたレモングラスの抽出液を含浸させたものであることを特徴とする認知症予防治療用マスクでもある。 << Mask for Dementia Prevention Treatment (2) >>
In healthy individuals, brain activity is enhanced, the brain is activated, cortisol secretion is increased, there is an anti-stress effect, and further appetite enhancement is impregnated with the lemongrass aqueous extract of the present invention. This shows that the brain activation mask is useful as a mask for preventing and treating dementia. The brain activation mask of the present invention exhibits the effect of the present invention particularly when used for a dementia patient or a person who wants to prevent dementia.
Accordingly, the present invention is a mask for preventing and treating dementia that enhances cranial nerve activity as a measure against dementia, stirring lemon grass while crushing with a stirring blade, and applying heat from the outside under the crushing and stirring. It is also a mask for preventing and treating dementia, which is impregnated with a lemongrass extract extracted by an extraction method having a step of extracting under reduced pressure.
<低温真空抽出法によるレモングラスの水性抽出液の調製>
レモングラスを、図1~3に示した容器(株式会社F・E・C製)に入れて抽出を行った。
抽出条件は以下であった。
(1)レモングラスの温度:30~40℃
(2)容器内の設定温度:35~40℃
(3)圧力:101.3kPa(1気圧)に対し、93~97kPa低い圧力
(4)撹拌羽根(可動刃)の回転数:4rpm(回転/分) Preparation Example 1
<Preparation of Lemongrass aqueous extract by low-temperature vacuum extraction method>
Lemongrass was extracted into the container (manufactured by FE Co., Ltd.) shown in FIGS.
The extraction conditions were as follows.
(1) Lemongrass temperature: 30-40 ° C
(2) Set temperature in the container: 35-40 ° C
(3) Pressure: 93-97 kPa lower pressure than 101.3 kPa (1 atm) (4) Rotation speed of stirring blade (movable blade): 4 rpm (rotation / min)
<低温真空抽出法によるレモングラス以外の水性抽出液の調製>
レモングラスに代えて、サクラ、ラベンダー、ランを用いた以外は、調製例1と同様にして、サクラの抽出物、ラベンダーの抽出物、及び、ランの抽出物をそれぞれ調製した。 Preparation Example 2
<Preparation of aqueous extract other than lemongrass by low temperature vacuum extraction>
A cherry extract, a lavender extract, and an orchid extract were prepared in the same manner as in Preparation Example 1 except that cherry, lavender, and orchid were used instead of lemongrass.
<マスクの調製>
図4に示したように、レモングラス、サクラ、ラベンダー及びランからの低温真空抽出法による水性抽出物を、水等で希釈せずにそのまま、それぞれ0.1gろ紙に染みこませ、ガーゼでできた汎用の市販のマスク内にそれぞれ挿入してマスクを調製した。 Preparation Example 3
<Preparation of mask>
As shown in FIG. 4, the aqueous extract obtained by low-temperature vacuum extraction from lemongrass, cherry, lavender and orchid is soaked in 0.1 g filter paper as it is without being diluted with water or the like. A mask was prepared by inserting each into a general-purpose commercially available mask.
<NIRSによる非侵襲的脳活動の測定(脳の活性化と沈静化の測定)>
調製例3で得られたレモングラスの水性抽出液が含侵されたマスクを、10名の被験者について、30分間装着してもらい、その後、NIRS測定を行った。このマスクを、図7では「レモングラスマスク」と略記する。
対照として、「マスク未装着」を評価した。
また、対照として、水性抽出物を染みこませない調製例で使用したのと同様の「ガーゼでできた汎用の市販のマスク」を30分装着してもらい、その後、NIRS測定を行った。このマスクを、図7では「市販のマスク」と略記する。 Example 1
<Measurement of non-invasive brain activity by NIRS (measurement of brain activation and calming)>
The masks impregnated with the lemongrass aqueous extract obtained in Preparation Example 3 were worn for 10 minutes for 10 subjects, and then NIRS measurement was performed. This mask is abbreviated as “lemongrass mask” in FIG.
As a control, “no mask” was evaluated.
Further, as a control, the same “general-purpose commercial mask made of gauze” as used in the preparation example in which the aqueous extract was not soaked was worn for 30 minutes, and then NIRS measurement was performed. This mask is abbreviated as “commercially available mask” in FIG.
なお、図7では、赤部分が活性化、青部分が沈静化であるが、白黒であって赤と青の区別が付かないため、図7中に指示線を記載した。右側にある縦長のゲージは、上に行くほど赤く(活性化)、下に行くほど青い(沈静化)。図8~10でも同様である。 The results are shown in FIG. Among 10 subjects, 6 were observed to activate cranial nerve activity when wearing a lemongrass mask.
In FIG. 7, the red portion is activated and the blue portion is calmed down. However, since black and white are indistinguishable from red and blue, an indication line is shown in FIG. 7. The vertical gauge on the right side is red as it goes up (activated) and blue as it goes down (sedation). The same applies to FIGS.
実施例1において、レモングラスをサクラに代えた以外は、実施例1と同様にNIRSによる評価を行った。
結果を図8に示す。被験者10名の内、5名はサクラマスク装着時に脳神経活動の活性化が観察された。 Comparative Example 1
In Example 1, evaluation by NIRS was performed in the same manner as in Example 1 except that lemongrass was replaced with cherry.
The results are shown in FIG. Among the 10 subjects, activation of cranial nerve activity was observed in 5 subjects when the cherry mask was worn.
実施例1において、レモングラスをラベンダーに代えた以外は、実施例1と同様にNIRSによる評価を行った。
結果を図9に示す。被験者10名の内、5名はラベンダーマスク装着時に脳神経活動の活性化が観察された。 Comparative Example 2
In Example 1, evaluation by NIRS was performed in the same manner as in Example 1 except that lemongrass was replaced with lavender.
The results are shown in FIG. Of the 10 subjects, 5 were observed to activate cranial nerve activity when wearing a lavender mask.
実施例1において、レモングラスをランに代えた以外は、実施例1と同様にNIRSによる評価を行った。
結果を図10に示す。被験者10名の内、7名はランマスク装着時に脳神経活動の変化がなかった。 Comparative Example 3
In Example 1, evaluation by NIRS was performed in the same manner as in Example 1 except that lemongrass was replaced with orchid.
The results are shown in FIG. Of the 10 subjects, 7 had no change in cranial nerve activity when the run mask was worn.
被験者10名における、各マスク装着による脳神経活動の変化(脳の活性化と沈静化)を図11にまとめた。図11では、被験者10名中、活性化、変化なし、沈静化の人数を表中に記載した。
調製例1で得られた「レモングラスの水性抽出液」を含浸させたレモングラスマスクで、最も脳神経活動の活性化が見られた。
このことは、該レモングラスマスクが、脳活性化用マスクであることを示し、認知症予防治療用マスクであることも示している。 <Summary of Example 1 and Comparative Examples 1 to 3>
The changes in cranial nerve activity (activation and calming of the brain) of each of the 10 subjects wearing the masks are summarized in FIG. In FIG. 11, among the 10 subjects, the number of activation, no change, and calming is shown in the table.
In the lemongrass mask impregnated with the “lemongrass aqueous extract” obtained in Preparation Example 1, activation of cranial nerve activity was most observed.
This indicates that the lemongrass mask is a brain activation mask and also a dementia prevention and treatment mask.
<唾液中のコルチゾールの測定(抗ストレスの測定)>
調製例3で得られたレモングラスの水性抽出液が含侵されたマスクを、10名の被験者について、30分間装着してもらい、唾液中のコルチゾールの量を測定した。このマスクを、図13では「レモングラスマスク」と略記する。
対照として、「マスク未装着」を評価した。
また、対照として、レモングラスの水性抽出物を染みこませない調製例で使用したのと同様の「ガーゼでできた汎用の市販のマスク」を30分装着してもらった。このマスクを、図13では「市販のマスク」と略記する。
唾液中のコルチゾールの測定は、常法に従って行った。 Example 2
<Measurement of salivary cortisol (measurement of anti-stress)>
Masks impregnated with the aqueous extract of lemongrass obtained in Preparation Example 3 were worn for 10 subjects for 30 minutes, and the amount of cortisol in saliva was measured. This mask is abbreviated as “lemongrass mask” in FIG.
As a control, “no mask” was evaluated.
In addition, as a control, the same “general-purpose commercial mask made of gauze” as used in the preparation example in which the lemongrass aqueous extract was not soaked was worn for 30 minutes. This mask is abbreviated as “commercially available mask” in FIG.
Cortisol in saliva was measured according to a conventional method.
このことは、該レモングラスマスクが、コルチゾール分泌抑制用マスク、従って抗ストレス用マスクとしても有用であることを示し、更に認知症予防治療用マスクとしても有用であることも示している。 The results are shown in FIG. FIG. 13 shows that the amount of cortisol in saliva decreases when this lemongrass mask is worn.
This indicates that the lemongrass mask is useful as a cortisol secretion suppression mask, and therefore as an anti-stress mask, and also useful as a mask for dementia prevention and treatment.
図14に示したように、充分なエサをいれた飼育箱の中で、ラットに毎日30分間、調製例1で得られたレモングラスの水性抽出液の香りを嗅がせ、6日間、体重の変化を測定した。それぞれ4匹のラットの体重変化を測定し相加平均を求めた。結果を図15に示す。 Example 3
As shown in FIG. 14, in a breeding box containing sufficient food, the rats were allowed to smell the lemongrass aqueous extract obtained in Preparation Example 1 for 30 minutes every day for 6 days. Changes were measured. The change in body weight of each of four rats was measured, and the arithmetic mean was determined. The results are shown in FIG.
このことは、レモングラスの水性抽出液が、食欲増進に効果があることを示している。
従って、本発明の脳活性化用マスクは、食欲増進用マスクとして有用であることを示し、更には食欲が増進するので、認知症予防治療用マスクとして有用であることも示している。 As can be seen from FIG. 15, the rate of increase in the average body weight of the rat sniffed with the lemongrass aqueous extract was significantly increased compared to the rat normally reared without sniffing.
This indicates that the lemongrass aqueous extract is effective in promoting appetite.
Therefore, the brain activation mask of the present invention is useful as an appetite enhancement mask, and further, since appetite is enhanced, it is also useful as a mask for dementia prevention treatment.
調製例1において、レモングラスから低温真空抽出法によって抽出することに代えて、レモングラスから、水蒸気蒸留法、水・エタノール混合抽出溶媒による溶媒抽出法を用いて抽出した。調製例3と同様にしてマスクを作製して、実施例1と同様にして評価したが、実施例1に比較して何れも活性化が低減した。
その原因として、有効成分の変質又は散逸;レモングラス由来ではない物質(天然物ではない物質)の混入;等が考えられた。 Comparative Example 4
In Preparation Example 1, instead of extracting from lemongrass by a low-temperature vacuum extraction method, extraction was performed from lemongrass using a steam distillation method or a solvent extraction method using a water / ethanol mixed extraction solvent. A mask was produced in the same manner as in Preparation Example 3 and evaluated in the same manner as in Example 1. However, the activation was reduced in all cases compared with Example 1.
Possible causes include alteration or dissipation of active ingredients; contamination of substances not derived from lemongrass (non-natural products); and the like.
従って、本発明の脳活性化用マスクは、認知症予防治療用、コルチゾール分泌抑制用、抗ストレス用、食欲増進用として有用であるため、医療品分野、医薬品分野、介護用品分野等において広く利用されるものである。 The lemongrass extract impregnated in the brain activation mask of the present invention contains lemongrass cell water as it is and has a component composition different from that of conventional lemongrass extracts. In addition, the lemongrass extract in the present invention is derived from a plant, and it is not necessary to use an extraction solvent in the extraction process.
Therefore, the brain activation mask of the present invention is useful for preventing or treating dementia, for inhibiting cortisol secretion, for anti-stress, and for promoting appetite, and is therefore widely used in the medical field, pharmaceutical field, nursing care field, etc. It is what is done.
2 冷却槽
6 撹拌羽根
7 下部半円筒部
8 上部角形部
9 蒸気室
10 排出口
14 排気口
16 配管
17 投入口
18 蓋
20 端壁
21 端壁
22 端板
23 端板
24 羽根体
24a 溝
24b 可動刃
25 羽根体
25a 溝
25b 可動刃
26 固定刃
30 傾斜面
31 レモングラス
32 真空計
33 温度計
34 温度計
41 回収槽
45 バルブ
46 減圧装置
49 弁
50 油層
51 水層
R 回転方向 DESCRIPTION OF
Claims (12)
- レモングラスを撹拌羽根で破砕しながら撹拌し、該破砕・撹拌下に外部から熱を加えつつ減圧して抽出する工程を有する抽出法により抽出されたレモングラスの水性抽出液を含浸させたものであることを特徴とする脳活性化用マスク。 It is impregnated with an aqueous extract of lemongrass extracted by an extraction method that has a step of crushing lemongrass with a stirring blade and extracting under reduced pressure while applying heat from the outside under crushing and stirring. A mask for brain activation characterized by being.
- 上記抽出は、外部からの加熱と蒸発熱による冷却で、レモングラスが20℃以上50℃以下の温度を維持するようにしてなされた請求項1に記載の脳活性化用マスク。 The brain activation mask according to claim 1, wherein the extraction is performed by external heating and cooling by evaporation heat so that the lemongrass maintains a temperature of 20 ° C or higher and 50 ° C or lower.
- 上記抽出が、101.3kPa(1気圧)に対し、80kPa以上低い圧力を維持しつつなされた請求項1又は請求項2に記載の脳活性化用マスク。 3. The brain activation mask according to claim 1 or 2, wherein the extraction is performed while maintaining a pressure lower by 80 kPa or more than 101.3 kPa (1 atm).
- 少なくとも主たる抽出中は、1kPa以上10kPa以下の圧力を維持しつつ抽出された請求項1ないし請求項3の何れかの請求項に記載の脳活性化用マスク。 The brain activation mask according to any one of claims 1 to 3, wherein the mask is extracted while maintaining a pressure of 1 kPa to 10 kPa at least during main extraction.
- 上記破砕しながらの撹拌が、可動刃及び/又は固定刃を備えた抽出装置内でなされた請求項1ないし請求項4の何れかの請求項に記載の脳活性化用マスク。 The brain activation mask according to any one of claims 1 to 4, wherein the agitation while crushing is performed in an extraction device including a movable blade and / or a fixed blade.
- 認知症予防治療用である請求項1ないし請求項5の何れかの請求項に記載の脳活性化用マスク。 The mask for brain activation according to any one of claims 1 to 5, wherein the mask is for dementia prevention treatment.
- 抗ストレス用である請求項1ないし請求項6の何れかの請求項に記載の脳活性化用マスク。 The mask for brain activation according to any one of claims 1 to 6, wherein the mask is for anti-stress.
- 認知症対策用として脳神経活動を亢進させる認知症予防治療用マスクであって、レモングラスを撹拌羽根で破砕しながら撹拌し、該破砕・撹拌下に外部から熱を加えつつ減圧して抽出する工程を有する抽出法により抽出されたレモングラスの抽出液を含浸させたものであることを特徴とする認知症予防治療用マスク。 A mask for preventing and treating dementia that enhances cranial nerve activity as a measure against dementia, a process in which lemongrass is stirred while being crushed with a stirring blade, and extracted by decompressing while applying heat from the outside under the crushing and stirring. A mask for preventing and treating dementia, which is impregnated with an extract of lemongrass extracted by an extraction method comprising:
- 請求項1ないし請求項7の何れかの請求項に記載の脳活性化用マスクであることを特徴とする認知症予防治療用マスク。 A mask for preventing and treating dementia, which is the brain activation mask according to any one of claims 1 to 7.
- 請求項1ないし請求項7の何れかの請求項に記載の脳活性化用マスクであることを特徴とする抗ストレス用マスク。 An anti-stress mask, which is the brain activation mask according to any one of claims 1 to 7.
- 請求項1ないし請求項7の何れかの請求項に記載の脳活性化用マスクであることを特徴とするコルチゾール分泌抑制用マスク。 A mask for suppressing cortisol secretion, which is the brain activation mask according to any one of claims 1 to 7.
- 請求項1ないし請求項7の何れかの請求項に記載の脳活性化用マスクであることを特徴とする食欲増進用マスク。 An appetite promoting mask, which is the brain activation mask according to any one of claims 1 to 7.
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JP2020147547A (en) * | 2019-03-15 | 2020-09-17 | Shiodaライフサイエンス株式会社 | Autonomic nerve regulator and gas nasal administration agent containing autonomic nerve regulator |
JP7260090B2 (en) | 2019-03-15 | 2023-04-18 | Shiodaライフサイエンス株式会社 | AUTONOMIC NERVE MODULATING AGENT AND GAS TRANSNASAL ADMINISTRATION CONTAINING THE AUTONOMIC NERVE MODULATING AGENT |
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