JPS63199292A - Perfume composition and cosmetics containing the same - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION <Industrial Application Field> The present invention relates to a perfume composition and a perfumed cosmetic product flavored with the perfume composition. More specifically, the present invention relates to a fragrance composition containing sandalwood oil and/or chamomile oil (camomile oil) in the fragrance, and to cosmetics flavored with the composition.

<Conventional technology> Traditionally, in Europe, starting from "herbal therapy,""phytotherapy" and "phytotherapy," which use the therapeutic effects of complexes of ingredients that are understood as active substances, have been introduced as folk remedies. However, French comparative pathologist R.M. Gaftefosse named the therapeutic application of the essential oils, taste substances, spices, and flavor components of herbs in aromatic herbal medicines as ``aromatherapy.'' Methods include rubbing aroma preparations, electrotherapy, spraying, dripping, or inhalation.

Its effects include awakening, hypnosis, suppressing appetite, promoting appetite, aversion to smoking, antiemetics, anti-syncope, aphrodisiac, and asexualization. Essential oils for excitement or awakening (drowsiness) include mint, eucalyptus, lemon, verbena,
Citronella, Kayabuchi.

Salvia, thyme, cloves, rosemary, basil, onion, garlic, etc. are listed as extracts. A list of soothing properties include aloe, chamomile, salvia, jasmine, neroli, rose, bergamot, camphor, geranium, sandalwood, ylang-ylang, lavender, mint, melissa, basil, patchouli, juniper, sage, lemon, eucalyptus, and thyme. (Okuda, Fragrance Ha 14G, 1
9. (1983)) (Volume 8, Fragrance Journal Extra Edition 6.241 (1986)).

As mentioned above, many people have talked about the effects of fragrance on the mind and psychology, but these are all based on what each person felt individually and according to legends. However, there is hardly anything that has been proven using modern scientific methods, which is why, as seen in the empirical classification above, lemon, flower, and eucalyptus.

There is an imbalance in thyme, which is classified as either sedation or excitement.

An example of scientific proof of this psychological effect is psychosomatic therapy (ear-nose perspective use) by Yo Hase et al.

(6), 753. (1973)), and the forest therapy of Susuda et al. (Environmental Information Science, 10-3. (1981)) are well known, but they are still being explored in the dark. However, recently, according to Lowell Ponch, human behavior is said to be influenced by scent, and its effects are rapidly attracting attention (Reader's Digest, Hisashi, 117. (198
3)).

Nutmeg oil and mace extract are used to relieve stress in humans by utilizing the psychological effects of aroma.

There are patent applications for substances selected from neroli oil and valerian oil, myristicin, elmicin, and isonilemicin (
In order to objectively investigate the effect, we investigated mental processes such as attention 1 expectation and anticipation, as well as slow potential fluctuations in the brain related to fluctuations in the level of consciousness (Cont.
ingent NegativeVariation
It has been reported that CN V (concomitant negative variation) can be an effective indicator of efficacy. That's Ashton
found an increase in CNV amplitude upon administration of caffeine, which is known to induce excitement or arousal, and a decrease in CNV amplitude upon administration of the sedative nitrazepam (Neurophysiol, 37, 59.
(1971)) A similar effect was observed in the amplitude of CNV before a nap and after drinking coffee following a nap. A similar increase in CNV amplitude was observed when smelling jasmine oil, which is empirically known to have a stimulant effect, and a decrease in CNV amplitude when a lavender-based preparation, Lavand, which is empirically known to have a sedative effect. (Torii et al., Abstracts of the Symposium on Taste and Smell, 65. (1895)).

<Problems to be Solved by the Invention> However, in these conventional techniques, various essential oils are simply selected empirically according to the purpose of sedation or stimulation, and it is not possible to determine the effect by using what and how much. I couldn't even predict how much I would get.

Therefore, we need a means to measure the effects of fragrances that have been predicted empirically, and we need to find and mix substances that produce certain effects to achieve specific effects.

For example, it has been desired to create a fragrance composition that causes excitement or sedation, and to eliminate mental and psychological troubles that are a problem in modern society by smelling the fragrance composition or cosmetics.

<Object of the Invention> Therefore, the object of the present invention is to select an active essential oil that exhibits a definite sedative or hypnotic effect from various essential oils, and to prepare a fragrance composition containing the active essential oil and a fragrance, and a fragrance composition containing the fragrance composition. The purpose is to provide cosmetics.

<Means for Solving the Problems> In order to realize the above-mentioned possibility, the present inventors have conducted extensive research, and as a result, have developed various techniques using Torii et al.'s concomitant negative variation (hereinafter abbreviated as CNV). As a result of researching the effects of essential oils and their respective concentrations, we found that the concentrations of essential oils conventionally used as fragrance materials, such as sandalwood extract and chamomile oil (hereinafter referred to as active essential oils), were found to be at higher concentrations than those normally used. The present invention was completed by discovering that when inhaled at a high content, a substance that was previously used for either sedation or stimulation, or for both, can have a mild sedative or hypnotic effect on humans.

That is, according to the present invention, it contains sandalwood oil and/or chamomile oil and a fragrance.

Sandalwood oil and/or chamomile oil
Provided is a fragrance composition characterized in that it contains 5% by weight or more of a sedative or hypnotic effect upon inhalation. Further, according to the present invention, there is provided a cosmetic product numbered with the perfume composition.

The sandalwood oil that can be used in the present invention has been used conventionally and is obtained by steam distilling the roots and heartwood of the sandalwood tree, whose Japanese name is sandalwood. The essential oil of the heartwood is pale yellow,
It has a yellowish brown color and is of excellent quality, and the sapwood is called ``sandalwood'', while the heartwood is called ``sandalwood''. The essential oil is a viscous liquid with a soft, sweet, wheezy, balsamic aroma.

Sandalwood oil is one of the most important fragrance materials due to its remarkable long-lasting properties, and blends well with essential oils such as rose, violet, tuberose, lavender, bergamot, chypre, fouzea carnation, origan, and almost all other blended fragrances. It is indispensable not only for heavy oriental fragrances, but also for modern modern floral, aldehydic, and spice fragrances.
981)).

There are two types of chamomile oil that can be used in the present invention: German chamomile and Roman chamomile, both of which can be used. By steam distilling these flower heads, you can obtain honey oil. Absolute is also called extracted honey oil. Chamomile is a folk medicine that has been used in Europe for a long time, and today's cosmetics use complex plant extracts such as chamomile, arnica, and hamamelis. When used alone, chamomile has anti-inflammatory effects, relieves congestion, and promotes wound healing, and is well known in Japan.From a cosmetic point of view, it gives luster to the skin and is effective against cracks and red spots. This is what is said to indicate. The scent of chamomile, reminiscent of the outdoors, is an eau de toilette fragrance for men with lavender and pine tones.

It is also used in amber-based mixed fragrances and Benedictine-type liqueurs (Kinumura, fragrance, kan 124.65
．． (1979)).

The above two types of "active essential oils" are effective alone or as a mixture in an amount of 5% by weight or more, preferably 5 to 20% by weight, which is outside the range of normal use as a fragrance. If it is less than 5% by weight, the sedative or hypnotic effect will not be significant and it cannot be used.
Although the upper limit is not particularly critical, the effect will not increase even if it exceeds 20% by weight, so 50% by weight is usually used as the upper limit, but 100% by weight may also be used.

Modulate it by adding fragrance ingredients that harmonize with it using normal perfumery methods, and finish by adding retention and body to create a good combination of top notes, middle notes, body notes, and last notes that will become attractive over time. Certain scents include floral scents such as rose, carnation, and jasmine, bouquet, modern,
Assemble a blended fragrance composition with characteristics such as chypre, laser, oriental, sitotaru, utsudi, aldehyde, etc.

This blended fragrance composition is as is (100%).

Or it can be used as a colon. "Active essential oil"
In order to ensure the effective amount of cologne, it is preferable to take into account the amount used, the number of times it is used, and the type of prescription, such as summer or winter use. Cologne is a blended fragrance that is made up of 1 to 99% blended fragrance and the remainder is alcohol or aqueous alcohol. The amount of water and alcohol in the aqueous alcohol may be 50% by weight or more.

You may add solubilizers, softeners, thickeners, bacteriostatic agents, and other base materials used in cosmetics to this cologne product.Normally, you can inhale a blended fragrance or cologne containing this "active essential oil." By doing so, this "active essential oil" is brought to the olfactory area and exhibits its effect.

The present invention can be carried out as a cosmetic product by using a cosmetic base material that is compatible with a mixed fragrance composition containing "active essential oil" and the above-mentioned mixed fragrance composition.

Cosmetics include basic cosmetics, hair cosmetics, finishing cosmetics,
Examples include toiletry products and fragrances.

Fabric softeners and talc are base materials used in cosmetics.

Examples include solid or liquid anionic, cationic, and nonionic active agents, polymeric agents, fats and oils, guar gum, xanthan gum, gum arabic, and gelatin. The weight ratio of blended fragrance and cosmetic base material is 0.5:・99.5 to 10
0:1, preferably in the range of 1:100 to 20:80 (Iwasaki, Fragrance Encyclopedia, 5
4. 1980 Asakura Shoten).

The weak sedative or hypnotic effect of perfume compositions and cosmetics prepared in this way can be applied to the skin or hair as a cosmetic, or can be applied to clothing, bath salts, fragrances, or by sniffing cosmetics used by others. The active essential oil is inhaled and brought to the nasal cavity, stimulating the olfactory receptors in the nasal cavity, causing pulses from the receptors to reach the brain and be perceived as a smell.

At that time, it is thought to have a mild sedative or hypnotic effect. Waiter to measure this weak effect.

The method of V.G. et al. (Nature, 203, 380.
(1964)), and the influence of partial sleep deprivation on CNV by Yamasui et al. (Clinical EEG 24, 252. (19
Taking a hint from 82)), the present inventors focused on slow potential fluctuations in the brain.

He thought that this could be expressed as mental processes such as expectations and expectations, or as changes in the level of consciousness.

EEG electrodes for CNV recording were attached to the frontal and central unilateral regions, and unipolar drift was recorded using indifferent electrodes directly connected to the left and right ear lobes with a time constant of 10.0 to 5 seconds. In order to determine the state of eye movement artifacts mixed into the brain waves, we recorded the left eyeball in the vertical direction, and as a breathing monitor, we attached a breathing flow rate sensor under the nasal cavity with double-sided tape and recorded it.

The subject's response to light stimulation (LED) is recorded by attaching an electromyogram electrode to the ball of the foot. The CNV paradigm consists of three instructions: "Inhale, exhale."

The subject was made to breathe according to the experimenter's instructions, and during the third and final inhalation period, the odor bottle was brought close to the front of the subject's nasal cavity and the subject was allowed to smell it. Approximately 1 second after the subject smells the odor, a sound stimulus is presented (at this time a buzzer sounds: S,
), followed by SZ where the light emitting diode turns on after about 2 to 3 seconds.
>, the subject immediately makes a motor response (MR) by pressing a button held in the dominant hand to turn off the LED as quickly as possible. Wait for the EEG baseline drift to subside, start recording, and after the subject has become sufficiently accustomed to the CNV paradigm with a practice trial using a blank stimulus of sniffing something with no odor, use the sample for 20 to 40 minutes. Records are made with an interval of 20-30 seconds between trials. CNV recordings made before a 20-40 minute nap and after drinking coffee after the nap are designated as blank (2) and blank (2), respectively, and compared with the subsequent sample measurements.

The data was analyzed using A-D conversion (sampling frequency 100 Hz) L using a NEC 11 microcomputer PC-9801F2, and each irritating odor was added 10 to 16 times to obtain an average summation waveform of CNV. When adding,
Only trials without eye movements, artifacts due to myoelectric activity, or drifts in the electroencephalogram baseline are added up. CNV
The baseline is determined from the average voltage of 400 m5ec before S1. When the average addition waveform of the obtained CNV was examined for various essential oils, it was 400 to 100 after 81 presentations.
Focusing on the relaxation of the amplitude of the so-called early component of 0 m5ec, a decrease in the amplitude compared to the blank is observed for sandalwood oil and chamomile oil at specific concentrations. The concentration is also supported by the questionnaire results of subjects' awareness, and as mentioned above, it is 5% by weight or more, preferably 5 to 20% by weight. In particular, it is preferable to use sandalwood oil in an amount of 10% by weight or more and chamomile oil in an amount of 5% by weight or more.

Regarding the concentration that remains in the nasal cavity, considering the same as in the case of δ-9-tetrahydrocanapinol when inhaling marijuana smoke, the average inhalation rate of the subjects was 10 Q/l1in, and 50% of the evaporated substance was 50 inhaled and inhaled
Considering that % is evaporated, the amount retained in the nasal cavity is considered to be 25% of the evaporated amount of the sample amount.

<Examples> Next, the present invention will be explained by Examples and Test Examples.The test amounts used in the six Examples and Test Examples are as follows.

Sandalwood oil Mysore (produced in India) plant is Sa
A viscous liquid obtained by steam distillation of the wood and roots of ntalum album.

Specific gravity: d! s=0.969-0.978 refractive index:
n:' = 1.505-1.507 Chamomile oil (camomile oil) Manufactured by Roman FD Alcoworld Fragrances The plant is Matricaria chamo + mllla
It is an essential oil obtained by steam distillation of flower heads.

Specific gravity: d□, = 0.905 to 0.920 Refractive index = n″@
= 1.442~1.458 Lavand
) Bender-based blended fragrance manufactured by Rocher-Galley in France Fragrance content 5-10% Jasmine rNight blooming J manufactured by Jime Pan Company in the United States
asisinJ spray cologne Fragrance content 5-10% Preparation of active essential oil and active essential oil mixture
1, 10, 100% by weight) in diethyl phthalate (manufactured by Wako Pure Chemical Industries, Ltd.), 0.2 g of it was absorbed into a filter paper placed at the bottom of a wide-mouth bottle (6 am φ x 7 Gm), and immediately used for the test. provided.

1 liter Preparation of mixed fragrances Various mixed fragrances containing 10% or more of active essential oil mixture (
Chamomile oil (for air fresheners, neutral creams, colognes, bath salts, and soaps) as shown in Prescription Example 1.
50 indole
5 coumarin
10 oakmoss absolute
5 cis-3-hexenol °10% 30 cis-3-hexenyl acetate 10% 10 phenylacetaldehyde dimethyl acetal 30 styralyl acetate 10 cis-jasmone 15 α-methyl-3,4-
Methylenedioxyhydrocinnamic aldehyde
10 Hydroxy Citronella JL/'
200 phenylethyl alcohol 300
Methyl dihydrodiasmonate 50 diasmine base &2 75 [1] J Preparation of fragrance d-limonene 87.0 g, amino acid-based oil gelling agent N
-Lauroylglutamic acid dibutyl acid (CP-1
” manufactured by Ajinomoto Co., Inc.) 2.0 g, 1,2-polybutadiene (rJSRRB-8404 manufactured by Japan Synthetic Rubber Co., Ltd.)
Put 0.5g and 70.5g of BH into a 200mG beaker, heat and stir to dissolve at 135°C for 15 minutes, and then dissolve at 90°C.
The blended fragrance Lo of "Example 2" is maintained at 5 to 100°C.
g and stirred for 15 minutes until uniform. Thereafter, the mixture was filled into a transparent glass container, sealed, and left to cool. At this time, rapid cooling caused distortion in gel formation, which was not preferable. A firm, stable, gel-like fragrance was thus prepared.

Preparation of backyard bush eau de cologne 5 g of the blended fragrance obtained in Example 2 (Lorina FG-1 Takasago Fragrance Industry Co., Ltd. mK) and 75 g of brucine denatured alcohol,
The mixture was thoroughly mixed with 20 g of water, left in a cool, dark place at about 10° C. for 4 days, and then filtered through a filter paper to obtain an eau de toilette.

Preparation of Neutral Cream According to the following recipe, take distilled water in an emulsifier, add ingredients A one after another, and heat to 85°C while stirring.

After uniformity at this temperature, the mixture was gradually cooled. When the temperature reached 50°C, component B was added. When the mixture became sufficiently homogeneous, component C was added little by little to adjust the pH to 4, and the mixture was poured into a predetermined container at about 40° C. and cooled to obtain a neutral cream.

Formulation example 2 (parts by weight) Component A: Monostearic acid glyceride
3.0 [“Arasel 165” manufactured by Kao Atlas Co., Ltd.
]Cetanol 3.5
Stearic acid 1.0 White petrolatum 5.0 Glycerin 5.0 Monostearic acid glyceride 3.0 [Nikko Chemical Co., Ltd. "Nitsuko/L/MGS-BSE"] Paraaminobenzoic acid butyl and methyl ester each Q, 1 Distilled water Amount B where the total amount is 100
Ingredients: Mixed fragrance obtained in Example 2 10.0
Ingredients: Citric acid and sodium citrate (50:50) aqueous solution 0.5% [111] Preparation of bath agent According to the following Formulation Example 3, first take distilled water into an emulsifying pot with a stirrer equipped with a heating and cooling device. Ingredients A were added and mixed one after another, heated to 85° C. with stirring, sufficiently uniformed at this temperature, and then slowly cooled.

When the temperature reached 50°C, component B was added thereto and stirring was continued. Then, the entire mixture was made uniform to obtain a bath additive.

The amount of this bath salt used is 15 for a normal family bath (-use).
It was appropriate to add about 10 g to 0Ω bath water.

Formulation example 3 (parts by weight) Component A: monostearic acid glyceride -1,
0 [Niracol MGS-BS manufactured by Nikko Chemical Co., Ltd.
H”] monostearic acid glyceride 1.5
[“Aracel 165” manufactured by Kao Atlas Co., Ltd.] Setanol 0.5 Nonionic surfactant 3.0 [“Emarex 5EP-4” manufactured by Nippon Emulzimin Co., Ltd.] Glycerin 10.0 Dehydroacetic acid
0.2 distilled water
Amount with the total amount being 100 Ingredient B: Mixed fragrance for bath additives prepared in Example 2 5.0 ml Preparation of machine-kneaded transparent soap Mixed fat and oil consisting of 70 parts of beef tallow, 20 parts of coconut oil, and 10 parts of castor oil was saponified with a mixture of 42.48 parts of a 35.36% aqueous sodium hydroxide solution and 2 parts of water, the excess free alkali was neutralized using 0.6 part of coconut oil fatty acid, and the resulting soap glue was placed on a cooling roll. The mixture was cooled and solidified to obtain ribbon-shaped soap pieces (sheet-shaped bodies). This was repeated by repeating the roll milling process in a conventional manner, and the material became transparent as water evaporated.

Next, 1.5% by weight of the floral bouquet fragrance obtained in Example 2 was added to and mixed with this ribbon, followed by roll milling and refiner treatment, and the ribbon was sent to a final vacuum extruder, from which one extruded soap was prepared. .

<Test example> k kayu The methods and procedures are as follows.

1) Subjects: Five examiners (38 to 45 years old) and five healthy adults (female, 23 to 35 years old) were the subjects.

2) Trial amount used: The trial amount used is as shown in Tables 1 and 2, and a blank, which is an odorless stimulus, was prepared as a control.

3) CNV recording: The electroencephalogram electrode is attached only to the frontal region (F2) on the midline, and the time constant is 3 with the earlobe as the indifferent electrode.
．． Single pole was derived in 0 seconds. Also.

Vertical eye movements of the left eye were also recorded.

4) CNV paradigm: CNV paradigm is Sl (sound stimulation by buzzer) - 82 (light stimulation by LED) interval 2
．． 3 seconds, and the motor response (M
R) was carried out. The fragrance was presented 1 to 2 seconds before S1.
The odor bottle was brought close to the front of the nasal cavity in time with the subject's inhalation phase.

After one practice trial, the subjects were asked to take a nap for 20 to 30 minutes in order to maintain a constant level of consciousness, and after waking up, they were made to drink coffee. Then take a 15-20 minute break,
First, for the blank, 2 with a trial interval of 10 to 20 seconds.
Five trials were recorded.

Following the blank, in Test Example 1, each test amount was recorded by 3 to 4 people, and 2 to 3 types of test amounts were measured for each test subject.

In Test Example 2, sandalwood oil, chamomile oil, or their mixture were tested at four concentrations (0, 1).
, 1, 5, 10, 100%), and three people each recorded the amount of each sample.

Analysis of data: The average addition waveform of CNV was calculated using a microcomputer (PC-9801 manufactured by NEC Corporation), excluding artifacts such as eye movement, and 10 to 1 for irritating odors.
It was calculated by adding 8 times. Further, the baseline of CNV was determined from the average pressure of 400+sec before Sl.

1L Addition amount of CNV early and early components for various sample amounts Example 2 The blended fragrance obtained in Example 1 and the sample amounts obtained in Examples 3 to 7 were placed in a wide-mouth bottle (6C! lφ x 7am). A certain amount was taken and used for CNV measurement. There were 3 test subjects for each sample. Table 1 shows the total amount of CNV early component in the trial amount.

2 Kamomino Masuyu 10% DEPI 0.2
g 25 47 803 Prescription example 1 fragrance example 2) 0.2g 29 42 744 Air freshener □□□Travel example 3) 2g 24
46 625 Haute Colon Gorge Example 4) 2
g3045646 Neutral cream chariot example 5)
2g2841727 Bath salt compensation example 6)
2g 30 47 708 Machine kneaded transparent soap compensation example 7) 2g 31 48 7
79 Jasmine (Roger Galley BDO, 2g
117 140 151 The relationship between the sample and the CNV amplitude is shown in FIG.

Various concentrations of sandalwood oil and chamomile oil, either individually or as a mixture, were prepared by diluting them with diethyl phthalate (DEP) and subjected to a test according to Test Example 1 to measure CNV. Measurement was carried out by 3 people per sample, and the percentage was calculated based on the value in the quasi-state of the total amount of CNV early and early components. Table 2 shows the average amplitude percentage and questionnaire results at each concentration.

0.1 95 30.1 9
5 3&3. Sandalwood oil + chamomile oil (50:50) 0.1 96
310 50 ・12 Nα4. Sandalwood oil + chamomile oil (70:30)
0.1 92 3 From the results in Table 2, the relationship between the concentration of "active essential oil" and CNV average amplitude % is shown in a graph as shown in FIG.

Table 12 Combining the CNV measurement results shown in Table 2 and the results of the 7-point scale questionnaire regarding sedation or hypnosis after sniffing each sample amount, it was found that a sedative or hypnotic effect was expressed at 5% by weight or more. In particular, it has been found that sandalwood oil exhibits a significant sedative or hypnotic effect at concentrations of 10% by weight or more and chamomile oil at 5% by weight or more.

<Effects of the Invention> The fragrance composition of the present invention and the cosmetics labeled with the fragrance composition as described above have a slight sedative or hypnotic effect on humans when inhaled, and therefore suppress the nervous irritability of modern society. However, it can be used for a wide range of purposes and can be expected to have some effect without having to take any medicine.

[Brief explanation of the drawing]

FIG. 1 is a graph showing the relationship between the sample according to Test Example 1 and the CNV amplitude. FIG. 2 is a graph showing the relationship between the concentration of active essential oil and CNV average amplitude % according to Test Example 2.

Claims (1)

[Claims] 1) Contains sandalwood oil and/or chamomile oil (chocolate oil) and a fragrance, and contains 5% by weight or more of sandalwood oil and/or chamomile oil (coconut oil) and is inhalable. A fragrance composition characterized by exerting a sedative or hypnotic effect. 2) Contains sandalwood oil and/or chamomile oil and fragrance, and contains 5% by weight or more of sandalwood oil and/or chamomile oil to produce a sedative or hypnotic effect when inhaled. 1. A cosmetic product characterized by being scented with a fragrance composition that gives a fragrance. 3) The cosmetic product according to claim 2, wherein the weight ratio of the fragrance composition to the cosmetic base material as a carrier is from 0.5:99.5 to 100:1.