WO2015018124A1 - 一种降血压中药制剂及其制备方法 - Google Patents
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- WO2015018124A1 WO2015018124A1 PCT/CN2013/085094 CN2013085094W WO2015018124A1 WO 2015018124 A1 WO2015018124 A1 WO 2015018124A1 CN 2013085094 W CN2013085094 W CN 2013085094W WO 2015018124 A1 WO2015018124 A1 WO 2015018124A1
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- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
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- A61P9/12—Antihypertensives
Definitions
- the invention relates to a traditional Chinese medicine preparation for lowering blood pressure, in particular to a traditional Chinese medicine preparation for reducing blood pressure and a preparation method thereof.
- cardiovascular disease As a common disease in human body, cardiovascular disease has become one of the major factors threatening the health of today's human beings.
- cardiovascular disease has become one of the major factors threatening the health of today's human beings.
- the pace of life and work has accelerated, and the eating habits have developed toward high-heating and high-lipidity.
- the number of hypertensive patients in the population has been increasing year after year.
- the commonly used antihypertensive drugs in domestic hospitals mainly include calcium channel blockers (levels), ACE-I (Puli) and angiotensin-II (sartans).
- Drug-based, Western medicine lipid-lowering drugs are statins as the leading products.
- traditional Chinese medicine cardiovascular disease treatment preparations have gradually become the best-selling varieties in the domestic market.
- traditional Chinese medicine preparations have the characteristics of "multi-target, multi-effect". Because Chinese medicine theory believes that the human body is a whole, the traditional Chinese medicine for blood stasis has the ability to remove atherosclerotic plaque, dredge blood vessels and accelerate blood circulation.
- the object of the present invention is to provide a traditional Chinese medicine preparation for preventing and treating hypertension, based on the above-mentioned deficiencies, combined with modern Chinese and Western medicine technology, and in particular to provide such a traditional Chinese medicine preparation and a preparation method thereof.
- the invention belongs to a traditional Chinese medicine compound medicine for clearing heat and calming liver, dissolving blood stasis and promoting blood circulation, treating symptoms such as head vertigo caused by hypertension and liver yang sputum, and the invention can quickly achieve antihypertensive effect, and is non-toxic and has no side effects.
- the pressure drop is stable, the effect is stable, and the preparation process is simple and easy.
- the preparation of the invention is pure water, stone cassia, wild chrysanthemum, solo, eucommia, hawthorn, motherwort, yinyanghuo, defensive, apocynum venetum, peony bark, yarrow, uncaria, chuanxiong, bupleurum, prunella , a liquid preparation of a composition prepared from a solution of bismuth, white sugar and 65% ethanol, wherein the mass ratio of each component is:
- the preferred original mass ratio of the present invention is: pure water 5000-8000g stone cassia 10-20g wild chrysanthemum 20-30g ⁇ 20-30g Eucommia 25-30g Hawthorn 20_25g Motherwort 15-20g Cistanche 20-25g Anti-self 20_25g Apocynum venetum 20-25g Mudanpi 20-25g Valerian 30-35g Uncaria 30-35g Chuanxiong 20-25g Bupleurum 20- 25g Prunella 20-30g ⁇ 10_20g White sugar 20-30g
- the present invention can also be used as a preferred raw material quality with purified water 6000g stone cassia 15g wild chrysanthemum 25g
- the preparation method of the above blood pressure lowering traditional Chinese medicine preparation comprises the following steps:
- Decoction for half an hour add 2 times the amount of water for 20 minutes, add for the third time. Decoction for 5 minutes with 5 times the amount of water, then combine the decoction and filter, set aside;
- apocynum venetum, peony bark, valerian, uncaria, chuanxiong, Bupleurum, Prunella, and sputum are proportioned, crushed by a pulverizer and passed through a 80 mesh sieve, and then at 50-70 ° C Dry at high temperature, then naturally dry to room temperature for use;
- the prepared Chinese medicine composition solution preparation can be used for oral administration, and if it can be consumed once in the morning and evening and long-term drinking, the effect is better.
- the theoretical basis of the present invention is: stone cassia, which is a shell of abalone variegated abalone, abalone, auricular abalone, and abalone.
- stone cassia As a traditional Chinese medicine, it tastes salty, cold, and has the effects of clearing heat, calming, lowering blood pressure, and sympathetic nerves.
- the stone cassia is salty and cold, and the quality is heavy and yang. It is specialized in the liver, and it has the functions of Pingganyang and Qingganzhe. It is the medicine for Lianggan and Zhengan.
- Stone Cassia also uses liver and kidney yin deficiency, liver and yang vertigo, liver yang sputum, liver sputum, dizziness, headache, irritability and irritability, can be with Prunella, Uncaria, wild chrysanthemum, etc. use. Wild chrysanthemum, the head of the perennial herb of the Compositae, is similar to chrysanthemum. It is wild on the hillside grassland and on the side of the road. Wild chrysanthemum can be widely used for detoxification, treatment of acne swelling, sore throat, red eyes, headache and dizziness.
- the single-flavored decoction has a general effect, but it is very effective in combination with other traditional Chinese medicines of the present invention.
- Living alone is the dry root of the genus Umbelliferae. Mainly produced in Sichuan, Hubei, Anhui and other places. In the early spring or late autumn, remove the roots and sediment, simmer until half dry, stack for 2 to 3 days, soften and then simmer until dry, then slice and use.
- Eucommia ulmoides the dry bark of Eucommia ulmoides, is a valuable nourishing herb in China.
- Eucommia ulmoides tea with eucommia ulmoides as raw material has many functions such as nourishing liver and kidney, strengthening bones and muscles, lowering blood pressure and curing fetus.
- Eucommia ulmoides is sweet and warm, has the functions of tonifying the liver and kidney, strengthening the bones and strengthening the fetus, and reducing the blood pressure with the combination of Duhuo and Mudanpi, and lowering the blood pressure without coldness.
- Hawthorn an edible plant, stone fruit, hard, thin flesh, slightly sour.
- Hawthorn is a deciduous shrub. Branches dense, with fine thorns, young branches with pilose. Branchlets purple brown, old branches taupe.
- Hawthorn is a unique combination of fruit and fruit in China.
- Hawthorn can eliminate product, sputum, stagnation, hawthorn and sour lush, hawthorn can prevent cardiovascular disease, have dilated blood vessels, strong heart, increase coronary blood flow, improve heart vitality, excite the central nervous system, reduce blood Compression and cholesterol, softening blood vessels and diuresis and sedative effects; prevention and treatment of arteriosclerosis, anti-aging, anti-cancer effect.
- Hawthorn acid also has a strong heart effect and is also beneficial for senile heart disease.
- Motherwort the whole grass of the motherwort of the Labiatae family. Wei Xin; bitter; sexual micro-introduction, can promote blood, phlegm, menstruation, water.
- Cistanche deserticola is an endangered species of the genus Cistanche, alias ⁇ , ⁇ , Cistanche, Chagan yue (Mongolian).
- Cistanche deserticola is a parasitic plant that is parasitic in the desert tree Haloxylon ammodendron and roots of red willow. It is distributed in Inner Mongolia, Ningxia, Gansu and Xinjiang. It is known as "desert ginseng" and has high medicinal value. It is a traditional Chinese traditional medicine.
- Cistanche is rich in alkaloids, crystalline neutral substances, amino acids, trace elements, vitamins and other ingredients. It can replenish kidney yang and benefit essence blood, can inhibit the appearance of "yang deficiency" symptoms and prevent weight loss. Anti-self, bitter, cold. You can drink water and shed heat. Treatment of edema and swelling, hot and cold athlete's foot, hand and foot pain, hemorrhoids swollen. For edema athlete's foot, urinary adverse, eczema sore, rheumatic pain, high blood pressure and other symptoms.
- Apocynum venetum leaves leaves of Apocynum venetum, more shrinking and curling, some broken, can treat high blood pressure, Apocynum venetum decoction has antihypertensive effect; Apocynum venetum decoction has a strong heart effect; Apocynum venetum leaf extract has Calm, anticonvulsant, and have strong diuretic, lower blood lipids, and immune Mudanpi, a dried root bark of the peony of the Ranunculaceae. Produced in Anhui, Shandong and other places. In the autumn, the roots are excavated, the fine roots are removed, the root bark is peeled off, and dried. Raw or fried.
- Valerian annual herb, cold, sin, bitter, liver, kidney, rheumatoid arthritis, weakness, weak waist, limb paralysis, hemiplegia, rubella, other blood vessels and blood pressure It has hurricane and collaterals, clearing heat and reducing blood pressure, and can be used in combination with Eucommia for hypertension and rheumatism.
- Uncaria also known as the big hooked, double hooked vine, is the hooked vine of the genus Uncaria or the genus Hookus and its genus of various plants with hooked branches, climbing shrubs, unripe vines, sweet and slightly cold, can calm the liver De-fire and heat, can be used with liver yang sputum caused by dizziness, head pass, red eyes and other diseases, hook vine stems contain a variety of steroidal alkaloids, including rhynchophylline, isoflavone, Uncaria , as well as non-alkaloids.
- the main effective antihypertensive components in Uncaria are rhynchophylline and isoflavone, and the latter has a stronger antihypertensive effect than rhynchophylline.
- Chuanxiong a kind of traditional Chinese medicine plant, is often used for promoting blood circulation, relieving pain and relieving pain. It is mainly cultivated in Sichuan, Yunnan, Guizhou, Guangxi, Hubei and other places. Chuanxiong Xin Wenxiang dry, go without keeping, can not only disperse, up to the dome; and into the blood, down to blood.
- Activating blood circulation Pan suitable for blood stasis to block various diseases; hurricane pain, good effect, can cure head wind headache, rheumatism and pain.
- Chuanxiong was a gas medicine in the blood, and it was said that it had functions such as disintegration, depression, accessibility, and pain relief.
- Bupleurum, sexually cold, bitter taste, Xin return to the liver, gallbladder, with the effect of soothing liver and gallbladder, suffocating and relieving depression, scattered fire.
- Symptoms because it has a good ability to clear the liver and fire, can be taken or decoction, for hypertension is liver heat, impotence. It is a terrestrial arthropod.
- the body is composed of many body segments. Each section has a foot foot, so it is a multi-legged creature. They are fast and aggressive.
- 65% ethanol solution contains alcohol.
- Liquor is known as "the longest of 100 medicines”. The liquor is stable, safe and effective, and because alcohol is a good semi-polar organic solvent, the various active ingredients of traditional Chinese medicine are soluble. Among them, the medicine exerts its effectiveness by means of alcohol and alcohol to help the drug, and improves the therapeutic effect.
- hypertension is a pathological process in which blood pressure regulation disorders and systemic arterial blood pressure continue to rise.
- the diagnostic criteria for hypertension refer to an increase in arterial systolic and/or diastolic blood pressure (140/90 mm Hg) at rest, often accompanied by disorders of fat and glucose metabolism, and heart, brain, Functional or organic changes in organs such as the kidney and retina, systemic diseases characterized by organ remodeling.
- the blood pressure of 140/90mmHg measured on 2 different times on the same day can be diagnosed as hypertension.
- many hypertensive patients, especially obese, are often accompanied by diabetes, and diabetes is also associated with high blood pressure, so the two are called homologous diseases.
- People with diabetes have increased blood sugar, increased blood viscosity, damaged blood vessel walls, and increased vascular resistance, which may cause high blood pressure. It can be seen that both hypertension and diabetes are related to hyperlipidemia. Therefore, both hypertension and diabetes should lower blood pressure and regulate blood lipids.
- Chinese traditional Chinese medicine believes that hypertension is caused by emotional internal injuries, unhealthy diet, fatigue and fatigue, or due to old age, kidney loss, etc., leading to imbalance of yin and yang, wind and fire endogenous, phlegm and stasis, qi and blood Caused by chaos.
- Treatment is usually divided into the following types: liver yang upper sputum type, liver and kidney yin deficiency type, yin and yang deficiency type, turbid middle resistance type, congestion block type, rushing disorder type.
- Western medicine also treats high blood pressure, and Western medicine often has frequent additions and subtractions to achieve the target blood pressure. Therefore, blood pressure fluctuations often occur.
- the traditional Chinese medicine has a mild antihypertensive effect and a good blood pressure stabilization effect.
- the invention is particularly suitable for early, middle-aged and elderly hypertensive patients, and the heavier hypertension is combined with the traditional Chinese medicine treatment of the present invention, and can also prevent large blood pressure fluctuations.
- the oral liquid of the preparation of the present invention is taken 1 hour after the meal, 3 times a day, 300 ml each time, 1 month is a course of treatment, and two courses are observed as therapeutic effects.
- the oral liquid of the preparation of the present invention is taken 1 hour after the meal, 3 times a day, 300 ml each time, 1 month is a course of treatment, and two courses are observed as therapeutic effects.
- the beneficial effects of the present invention are that the preparation prepared by the invention can achieve the symptoms of clearing heat and calming the liver, removing blood stasis and promoting blood circulation, lowering blood pressure and treating head vertigo caused by liver yang sputum.
- the invention can quickly achieve the antihypertensive effect, and is non-toxic, has no side effects, has stable blood pressure, stable effect, and the preparation process is simple and easy.
- the preparation of the invention is pure water, stone cassia, wild chrysanthemum, solo, eucommia, hawthorn, motherwort, yinyanghuo, defensive, apocynum venetum, peony bark, yarrow, uncaria, chuanxiong, bupleurum, prunella , a liquid preparation of a composition prepared from a solution of bismuth, white sugar and 65% ethanol, wherein the mass ratio of each component is:
- the preparation method of the above blood pressure lowering traditional Chinese medicine preparation comprises the following steps:
- apocynum venetum, peony bark, valerian, uncaria, chuanxiong, Bupleurum, Prunella, and sputum are proportioned, crushed by a pulverizer and passed through a 80 mesh sieve, and then at 50-70 ° C Dry at high temperature, then naturally dry to room temperature for use;
- the preparation of the above-mentioned traditional Chinese medicine composition solution can be used for oral administration, and if it can be consumed once in the morning and evening and long-term drinking, the effect is better.
- Example 2 The preferred raw material quality of the present invention is (g):
- the preparation method is as in Example 1.
- the mass of each component is (g):
- the mass of each component is (g):
- the preparation method is as in Example 1.
- the mass of each component is (g):
- the preparation method is as in Example 1.
- the mass of each component is (g):
- the preparation method is as in Example 1.
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Abstract
一种降血压中药制剂及其制备方法。本发明制剂是由纯净水、石决明、野菊花、独活、杜仲、山楂、益母草、淫羊霍、防己、罗布麻叶、牡丹皮、豨莶草、钩藤、川芎、柴胡、夏枯草、蜈蚣、白糖和65%乙醇溶液经过粉碎、煎煮、混合、搅拌等工艺制备成的液态制剂。所述制剂,可以清热平肝,化痰活血,降低血压和治疗肝阳上亢引起的头部眩晕等症状,能够较快的达到降压效果,而且无毒,无副作用,降压平稳,效果稳定,制取工艺简便易行。
Description
一种降血压中药制剂及其制备方法 技术领域
本发明涉及一种降血压作用的中药制剂,具体的说是涉及这种降 血压作用的中药制剂及其制备方法。 背景技术
作为人身常见的一种疾病,心血管疾病已经成为威胁当今人类健 康的重大因素之一。近年来, 随着我国人口的老龄化以及人们生活水 平的提高, 生活、 工作节奏的加快, 饮食习惯向高热化、 高脂化方向 的发展, 人群中的高血压患者连年呈递增趋势。
目前, 针对降血压问题, 国内医院常用抗高血压药物主要以钙通 道阻滞剂(地平类)、 ACE— I (普利类)和血管紧张素酶一 II抑制(沙 坦类)三大类药物为主, 西药类降血脂药是他汀类为主导产品, 近些 年来中药类心血管病治疗制剂已逐渐成为国内市场上的畅销品种。与 西药制剂相比, 中药制剂具有 "多靶点、 多效应 "的特点, 因为中医 理论认为, 人体是一个整体, 故活血瘀类中药具有削除动脉粥样硬化 斑块, 疏通血管和加速血液循环等多种效果, 故中医类心血管病制剂 与作用单一的西药制剂相比更具优势。这表明我国广大病人对中药类 心血管制剂临床效果的认可,但目前市场上的中药药物治疗有些治标 不治本, 有些使用价格昂贵的成分, 很多产品降压效果不明显, 降压 后效果不稳定, 很容易反弹上升, 所述缺陷值得改进。
本发明的目的即在于针对上述不足, 在祖传秘方的基础上, 结合 现代中西医技术, 提供一种预防和治疗高血压的中药制剂, 具体的说 是提供这种中药制剂及其制备方法, 本发明属于一种清热平肝, 化痰 活血,主治高血压和肝阳上亢引起的头部眩晕等症状的中药复方药物, 本发明能够较快的达到降压效果, 而且无毒, 无副作用, 降压平稳, 效果稳定, 制取工艺简便易行。
本发明的技术方案如下所述:
本发明制剂是由纯净水、 石决明、 野菊花、 独活、 杜仲、 山楂、 益母草、 淫羊霍、 防己、 罗布麻叶、 牡丹皮、 豨莶草、 钩藤、 川芎、 柴胡、夏枯草、蜈蚣、白糖和 65%乙醇溶液制备成的组合物液态制剂, 其中各组分的质量配比为:
纯净水 4000-8000g 石决明 10- 30g 野菊花 20-40g 独活 20-40g 杜仲 25-35g 山楂 20- 30g 益母草 15-25g 肉苁蓉 20- 30g 防己 20-30g 罗布麻叶 20-30g 牡丹皮 20- 30g 豨莶草 30- 40g 钩藤 30-40g 川芎 20-30g 柴胡 20-30g 夏枯草 20-35g 蜈蚣 10- 20g 白糖 20-30g
65%乙醇溶液 15-30g。
为了获得更好的效果, 本发明可优选的原 质量配比为: 纯净水 5000-8000g 石决明 10— 20g 野菊花 20-30g
独活 20-30g 杜仲 25-30g 山楂 20_25g 益母草 15-20g 肉苁蓉 20-25g 防己 20_25g 罗布麻叶 20-25g 牡丹皮 20-25g 豨莶草 30-35g 钩藤 30-35g 川芎 20-25g 柴胡 20-25g 夏枯草 20-30g 蜈蚣 10_20g 白糖 20-30g
65%乙醇溶液 15-25g (
当然, 为了获得进一步好的效果, 本发明还可优选的原料质量配 纯净水 6000g 石决明 15g 野菊花 25g
独活 25g 杜仲 25g 山楂 20g
益母草 15g 肉苁蓉 20g 防己 20g
罗布麻叶 25g 牡丹皮 20g 豨莶草 30g
钩藤 30g 川芎 20g 柴胡 20g
夏枯草 25g 蜈蚣 15g 白糖 30g
65%乙醇溶液 20gc
上述降血压中药制剂的制备方法, 包括如下步骤:
1 )、 将石决明、 野菊花、 独活、 杜仲、 山楂、 益母草、 淫羊霍、 防己按比例配好, 经过粉碎机粉碎并过 80目筛, 然后在 50— 70°C的 高温下烘干, 然后自然晾到室温备用;
2 )、将上述步骤中石决明、野菊花、独活、杜仲、 山楂、益母草、 淫羊霍、 防己的粉末混合物加入纯净水煎煮三次, 第一次加入 10倍
:水煎煮半个小时, 第二次加入 5倍量水煎煮 20分钟, 第三次加入
5倍量水煎煮 10分钟, 然后合并煎液并过滤, 备用;
3 )、将罗布麻叶、牡丹皮、豨莶草、钩藤、川芎、柴胡、夏枯草、 蜈蚣按比例配好, 经过粉碎机粉碎并过 80目筛, 然后在 50— 70°C的 高温下烘干, 然后自然晾到室温备用;
4)、 将上述罗布麻叶、 牡丹皮、 豨莶草、 钩藤、 川芎、 柴胡、 夏 枯草、 蜈蚣的粉末混合物加入 10倍量的纯净水煎煮半个小时, 然后 取煎液并过滤, 备用;
5 )、 在室温状态下, 将上述步骤 2 ) 和步骤 4) 中获得的煎液混 合, 并加入 65%乙醇溶液并搅拌均匀, 形成中药组合物溶液制剂;
6 )、 将上述步骤 5 ) 中的中药组合物溶液制剂加入白糖, 并搅拌 5分钟, 即可制得。
制取的上述中药组合物溶液制剂可以用于口服,如果能够早中晚 各饮用一次并长期饮用, 效果更好。 本发明的理论依据在于: 石决明, 为鲍科动物杂色鲍、 皱纹盘鲍、 耳鲍、 羊鲍等的贝壳。 作为中药, 它味咸, 性寒, 有清热、 镇静、 降血压、 拟交感神经的作 用。 石决明咸寒清热, 质重潜阳, 专入肝经, 而有平肝阳、 清肝热之 功, 为凉肝、 镇肝之要药。 石决明还用治肝肾阴虚、 肝阳眩晕症, 肝 阳上亢、 肝火亢盛、 头晕头痛、 烦躁易怒者, 可与夏枯草、 钩藤、 野 菊花等清热、 平肝药物同用。
野菊花, 为菊科多年生草本植物野菊的头状花序, 外形与菊花相 似, 野生于山坡草地、 田边路旁。 野菊花可广泛用于清热解毒, 治疗 疔疮痈肿、 咽喉肿痛、 风火赤眼、 头痛眩晕等病证。 同时又有很好的 降压作用, 可用于高血压病的辅助治疗。 单味煎服效果一般, 但是与 本发明其他中药为伍, 则效果非常突出。 独活, 为伞形科植物重齿毛当归的干燥根。 主产于四川、 湖北、 安徽等地。 春初或秋末采挖, 除去须根及泥沙, 炕至半干, 堆置 2〜 3天,发软后再炕至全干,然后切片,生用。我国医书古籍《本草正》: "专理下焦风湿, 两足痛痹, 湿痒拘挛。 "独活味苦, 微温。 归肝、 肾、 膀胱经, 现代研究, 独活有抗炎、 镇痛及镇静作用, 对血小板聚 集有抑制作用, 并有降血压作用。 杜仲, 为杜仲科植物杜仲的干燥树皮, 是中国名贵滋补药材。 以 杜仲叶为原料的杜仲茶具补肝肾、强筋骨、降血压、安胎等诸多功效。 杜仲性味甘温, 有补肝肾、 强筋骨、 安胎降压效用, 与独活、 牡丹皮 等配伍可降血压, 且对体虚之人降血压无寒凉之弊。 山楂, 为可食用植物, 核果类水果, 质硬, 果肉薄, 味微酸涩。 山楂树是落叶灌木。 枝密生, 有细刺, 幼枝有柔毛。 小枝紫褐色, 老 枝灰褐色。 山楂是我国特有的药果兼用树种。 山楂可以消积, 行瘀, 化滞, 山楂味酸甘性微温, 山楂能防治心血管疾病, 具有扩张血管、 强心、 增加冠脉血流量、 改善心脏活力、 兴奋中枢神经系统、 降低血
压和胆固醇、 软化血管及利尿和镇静作用; 防治动脉硬化, 防衰老、 抗癌的作用。 山楂酸还有强心作用, 对老年性心脏病也有益处。 益母草, 为唇形科植物益母草的全草。 味辛; 苦; 性微进, 可以 活血, 祛瘀, 调经, 消水。 治月经不调, 胎漏难产, 胞衣不下, 产后 血晕, 瘀血腹痛, 崩中漏下, 尿血, 泻血, 痈肿疮疡等症。 肉苁蓉, 肉苁蓉属列当科濒危种, 别名大芸、 寸芸、 苁蓉、 查干 告亚(蒙语) 。 肉苁蓉是一种寄生在沙漠树木梭梭、 红柳根部的寄生 植物,分布于内蒙古、宁夏、甘肃和新疆,素有 "沙漠人参"之美誉, 具有极高的药用价值, 是我国传统的名贵中药材, 也是历代补肾壮阳 类处方中使用频度最高的补益药物之一。 肉苁蓉含有丰富的生物碱、 结晶性的中性物质、 氨基酸、 微量元素、 维生素等成分。 能补肾阳、 益精血, 能抑制 "阳虚"症状的出现, 防止体重减轻。 防己, 味苦, 寒。 可以行水, 泻下焦湿热。 治水肿臌胀, 湿热脚 气, 手足挛痛, 癣疥疮肿。 用于水肿脚气, 小便不利, 湿疹疮毒, 风 湿痹痛, 高血压等症。 罗布麻叶, 为罗布麻的叶子, 多皱缩卷曲, 有的破碎, 可以治疗 高血压, 罗布麻叶煎剂有降压作用; 罗布麻根煎剂有强心作用; 罗布 麻叶浸膏有镇静, 抗惊厥作用, 并有较强的利尿、 降低血脂、 调节免
牡丹皮, 为毛茛科植物牡丹干燥根皮。 产于安徽、 山东等地。 秋 季采挖根部, 除去细根, 剥取根皮, 晒干。 生用或炒用。 我国古代医 术《本草纲目》 : "滋阴降火, 解斑毒, 利咽喉, 通小便血滞。 后人 乃专以黄蘖治相火, 不知丹皮之功更胜也。 赤花者利, 白花者补, 人 亦罕悟, 宜分别之。 "现代研究, 所含牡丹酚及其以外的糖苷类成分 均有抗炎作用; 牡丹皮的甲醇提取物有抑制血小板作用; 牡丹酚有镇 静、 降温、 解热、 镇痛、 解痉等中枢抑制作用及抗动脉粥样硬化、 利 尿、 抗溃疡等作用。 豨莶草, 一年生草本, 寒、 辛、 苦, 归肝经、 肾经, 用于风湿关 节炎、 筋骨无力 、 腰膝酸软、 四肢麻痹、 半身不遂、 风疹湿疮, 另 有扩张血管以及降压功能,有祛风通络,清热降压作用,可同杜仲等配 伍,用于高血压及风湿病。 钩藤, 别名又叫大钩丁、 双钩藤, 为茜草科植物钩藤或华钩藤及 其同属多种植物的带钩枝条, 攀援状灌木, 钩藤味甘、 性微寒, 可以 平肝熄火清热, 可用与肝阳上亢所致的眩晕、 头通、 目赤等症, 钩藤 茎枝中含有多种吲哚类生物碱, 包括钩藤碱、 异钩藤碱、 钩藤总碱, 以及非生物碱。钩藤中主要有效降压成分为钩藤碱和异钩藤碱, 后者 的降压效果强于钩藤碱。 川芎, 一种中药植物, 常用于活血行气, 祛风止痛, 主要栽培于 四川、 云南、 贵州、 广西、 湖北等地。 川芎辛温香燥, 走而不守, 既 能行散, 上行可达巅顶; 又入血分, 下行可达血海。 活血祛瘀作用广
泛, 适宜瘀血阻滞各种病症; 祛风止痛, 效用甚佳, 可治头风头痛、 风湿痹痛等症。 昔人谓川芎为血中之气药, 殆言其寓辛散、 解郁、 通 达、 止痛等功能。 柴胡, 性微寒、 味苦、 辛、 归肝经、 胆经, 具疏肝利胆、 疏气解 郁、 散火之功效。 夏枯草, 味辛, 苦, 性寒, 有清肝泻火、 疏肝散结、 化痰、 降压 效用, 常用于治疗高血压病且伴有头痛、 目炫、 耳鸣、 烦热、 失眠等 症状, 因为其有精良清泄肝火效用, 可泡服或煎服, 用于高血压病属 肝热、 阳亢者。 蜈蚣为陆生节肢动物, 身体由许多体节组成, 每一节上均长有步 足, 故为多足生物。 它们行动迅速, 具攻击性。 在中医上, 蜈蚣归肝 经,能够息风镇痉,功毒散结,通络止痛。用于小儿惊风,抽搐痉挛, 中风口歪,半身不遂,破伤风,风湿顽痹,疮疡,瘰疬,毒蛇咬伤等。
65%乙醇溶液含酒精,白酒素有"百药之长"之称,白酒性质稳定、 安全有效, 而且因为酒精是一种良好的半极性有机溶剂, 中药的各种 有效成分都易溶于其中, 药借酒力、 酒助药势而充分发挥其效力, 提 高治疗效果。 众所周知, 高血压病是指血压调控障碍, 体循环动脉血压持续升 高的病理过程。 高血压的诊断标准是指在静息状态下动脉收缩压和 / 或舒张压增高( 140/90mmHg) ,常伴有脂肪和糖代谢紊乱以及心、脑、
肾和视网膜等器官功能性或器质性改变,以器官重塑为特征的全身性 疾病。休息 5分钟以上, 2次以上非同日测得的血压 140/90mmHg可 以诊断为高血压。临床上很多高血压病人特别是肥胖型常伴有糖尿病, 而糖尿病也较多的伴有高血压, 因此将两者称之同源性疾病。糖尿病 人由于血糖增高, 血粘稠度增加, 血管壁受损, 血管阻力增加, 易引 起高血压。 由此可知高血压与糖尿病都与高血脂有关, 因此防治高血 压病与糖尿病都应该同时降血压、 调节血脂。 我国中医认为, 高血压病是因情志内伤、 饮食不节、 劳倦损伤, 或因年老体衰, 肾精亏损等导致脏腑阴阳平衡失调, 风火内生, 痰淤 交阻, 气血逆乱所致。 治疗时通常分为以下几种类型: 肝阳上亢型、 肝肾阴虚型、 阴阳两虚型、 痰浊中阻型、 淤血阻滞型、 冲任失调型等 几种。 西药也治疗高血压,西医常常有为达到目标血压而频繁加减药量 等情况, 因此, 也常常出现血压波动幅度较大的现象。 而中药降压作 用缓和, 稳定血压效果较好, 本发明尤其适用于早期, 中老年高血压 患者, 较重的高血压病配合本发明的中药治疗, 也可防止血压较大波 动。 临床实验 1:
1 )、观察时间:在本发明技术方案未曾披露的情况下,选择 2013 年 1月到 2013年 3月的 3个月时间。
2 )、观察对象:在广东省深圳市中医院选择 10例病例:男 5例, 女 5例; 年龄: 45— 55岁 5例, 55— 75岁 5例; 职业: 民营企业主 5例, 退休人员 5例。 病程: 清晨测量血压不低于 150/100mmHg, 偶 有头部眩晕, 目视不清, 四肢无力症状。
3 )、 使用方法: 将本发明制剂口服液在餐后 1小时服用, 每日 3 次, 每次 300ml, 1个月为 1疗程, 两个疗程作为疗效观察。
4)、 观察效果:
在连续服用两个疗程后,其中 4例患者降至不高于 120/90mmHg, 3 例降至不高于 130/90mmHg, 3例降至不高于 110/90mmHg。 停药 7天后 观察, 没有明显反弹迹象, 血压平稳, 头部眩晕消失, 目视不清、 四 肢无力状况大大改善。
临床实验 2:
1 )、观察时间: 在本发明技术方案未曾披露的情况下, 选择 2013 年 4月到 2013年 6月的 3个月时间。
2 )、 观察对象: 在广东省深圳市福田区中医院选择 10例病例: 男 6例, 女 4例; 年龄: 55— 65岁 5例, 65— 75岁 5例; 职业: 曾 担任岗位领导的肥胖型公务员 5例, 肥胖型普通退休公务员 5例。病 程:清晨测量血压不低于 170/110mmHg,常伴随头部眩晕, 目视不清, 四肢无力症状。
3 )、 使用方法: 将本发明制剂口服液在餐后 1小时服用, 每日 3 次, 每次 300ml, 1个月为 1疗程, 两个疗程作为疗效观察。
4)、 观察效果:
在连续服用两个疗程后, 其中 4 例患者降至不高于 130/100mmHg, 3 例降至不高于 120/100mmHg, 3 例降至不高于 1 10/90mmHg o 停药 7天后观察, 没有明显反弹迹象, 血压平稳, 头部 眩晕消失, 目视不清、 四肢无力状况有所改善。
结合以上临床数据及本发明的理论依据,可见本发明有益效果在 于, 本发明制成的制剂, 可以达到清热平肝, 化痰活血, 降低血压和 治疗肝阳上亢引起的头部眩晕等症状,本发明能够较快的达到降压效 果,而且无毒,无副作用,降压平稳,效果稳定,制取工艺简便易行。 具体实舫式
下面结合实施例对本发明详细加以说明:
实施例 1:
本发明制剂是由纯净水、 石决明、 野菊花、 独活、 杜仲、 山楂、 益母草、 淫羊霍、 防己、 罗布麻叶、 牡丹皮、 豨莶草、 钩藤、 川芎、 柴胡、夏枯草、蜈蚣、白糖和 65%乙醇溶液制备成的组合物液态制剂, 其中各组分的质量配比为:
纯净水 4000g 石决明 10g 野菊花 20g
独活 20g 杜仲 25g 山楂 20g
益母草 15g 肉苁蓉 20g 防己 20g
罗布麻叶 20g 牡丹皮 20g 豨莶草 30g
钩藤 30g 川芎 20g 柴胡 20g
夏枯草 20g 蜈蚣 10g 白糖 20g
65%乙醇溶液 15g。
上述降血压中药制剂的制备方法, 包括如下步骤:
1 )、 将石决明、 野菊花、 独活、 杜仲、 山楂、 益母草、 淫羊霍、 防己按比例配好, 经过粉碎机粉碎并过 80目筛, 然后在 50— 70°C的 高温下烘干, 然后自然晾到室温备用;
2 )、将上述步骤中石决明、野菊花、独活、杜仲、 山楂、益母草、 淫羊霍、 防己的粉末混合物加入纯净水煎煮三次, 第一次加入 10倍 量水煎煮半个小时, 第二次加入 5倍量水煎煮 20分钟, 第三次加入 5倍量水煎煮 10分钟, 然后合并煎液并过滤, 备用;
3 )、将罗布麻叶、牡丹皮、豨莶草、钩藤、川芎、柴胡、夏枯草、 蜈蚣按比例配好, 经过粉碎机粉碎并过 80目筛, 然后在 50— 70°C的 高温下烘干, 然后自然晾到室温备用;
4)、 将上述罗布麻叶、 牡丹皮、 豨莶草、 钩藤、 川芎、 柴胡、 夏 枯草、 蜈蚣的粉末混合物加入 10倍量的纯净水煎煮半个小时, 然后 取煎液并过滤, 备用;
5 )、 在室温状态下, 将上述步骤 2 ) 和步骤 4) 中获得的煎液混 合, 并加入 65%乙醇溶液并搅拌均匀, 形成中药组合物溶液制剂;
6 )、 将上述步骤 5 ) 中的中药组合物溶液制剂加入白糖, 并搅拌 5分钟, 即可制得。
制取的上述中药组合物溶液制剂可以用于口服,如果能够早中晚 各饮用一次并长期饮用, 效果更好。
实施例 2:
本发明还可优选的原料质量为 (克):
纯净水 8000g 石决明 30g 野菊花 40g 独活 40g 杜仲 35g 山楂 30g 益母草 25g 肉苁蓉 30g 防己 30g 罗布麻叶 30g 牡丹皮 30g 豨莶草 40g 钩藤 40g 川芎 30g 柴胡 30g 夏枯草 35g 蜈蚣 20g 白糖 30g
65%乙醇溶液 15g。
制备方法如实施例 1。
实施例 3:
其中各组分的质量为 (克):
纯净水 5000g 石决明 15g 野菊花 25g 独活 25g 杜仲 30g 山楂 25g 益母草 20g 肉苁蓉 25g 防己 25g 罗布麻叶 25g 牡丹皮 25g 豨莶草 35g 钩藤 35g 川芎 25g 柴胡 25g 夏枯草 25g 蜈蚣 15g 白糖 25g 65%乙醇溶液 20g。
制备方法如实施例 1
实施例 4:
其中各组分的质量为 (克):
纯净水 6000g 石决明 20g 野菊花 30g
独活 30g 杜仲 35g 山楂 30g 益母草 25g 肉苁蓉 30g 防己 30g 罗布麻叶 30g 牡丹皮 30g 豨莶草 35g 钩藤 35g 川芎 30g 柴胡 30g 夏枯草 30g 蜈蚣 20g 白糖 30g 65%乙醇溶液 25gc
制备方法如实施例 1。
实施例 5:
其中各组分的质量为 (克):
纯净水 7000g 石决明 10g 野菊花 20g 独活 20g 杜仲 25g 山楂 20g 益母草 25g 肉苁蓉 30g 防己 30g 罗布麻叶 30g 牡丹皮 30g 豨莶草 30g 钩藤 30g 川芎 20g 柴胡 20g 夏枯草 35g 蜈蚣 20g 白糖 20g 65%乙醇溶液 30gc
制备方法如实施例 1。
实施例 6:
其中各组分的质量为 (克):
纯净水 4500g 石决明 12g 野菊花 28g 独活 28 杜仲 28g 山楂 26g 母草 18g 肉苁蓉 22g 防己 22g
罗布麻叶 22g 牡丹皮 22g 豨莶草 38g 钩藤 38g 川芎 21g 柴胡 21g
夏枯草 23g 蜈蚣 12g 白糖 28g
65%乙醇溶液 18g。
制备方法如实施例 1。
上述实施例仅是本发明众多实施方式的几种,如将各配方按技术方案
I大或减小药量, 制得的这种降血压制剂疗效并不受影响, 也将落在本发明的权利保护范围之内。
Claims
1、一种降血压中药制剂,其特征在于,本发明制剂是由纯净水、 石决明、 野菊花、 独活、 杜仲、 山楂、 益母草、 淫羊霍、 防己、 罗布 麻叶、 牡丹皮、 豨莶草、 钩藤、 川芎、 柴胡、 夏枯草、 蜈蚣、 白糖和
65%乙醇溶液制备成的组合物液态制剂, 其中各组分的质量配比为: 纯净水 4000- 8000g 石决明 10-30g 野菊花 20- 40g 独活 20-40g 杜仲 25-35g 山楂 20- 30g 益母草 15-25g 肉苁蓉 20-30g 防己 20-30g 罗布麻叶 20-30g 牡丹皮 20-30g 豨莶草 30- 40g 钩藤 30-40g 川芎 20-30g 柴胡 20- 30g 夏枯草 20-35g 蜈蚣 10-20g 白糖 20-30g
65%乙醇溶液 15- - 30g。
2、 根据权利要求 1 ,所述的降血压中药制剂, 其特征还在于, 纯净水 5000-8000g 石决明 10-20g 野菊花 20-30g 独活 20-30g 杜仲 25-30g 山楂 20-25g 益母草 15-20g 肉苁蓉 20-25g 防己 20-25g 罗布麻叶 20-25g 牡丹皮 20-25g 豨莶草 30-35g 钩藤 30-35g 川芎 20-25g 柴胡 20-25g 夏枯草 20-30g 蜈蚣 10_20g 白糖 20-30g
65%乙醇溶液 15-25g。
3、根据权利要求 1或 2所述的降血压中药制剂,其特征还在于,
其中各组分的质量配比为
纯净水 6000g 石决明 15g 野菊花 25g
独活 25g 杜仲 25g 山楂 20g
益母草 15g 肉苁蓉 20g 防己 20g
罗布麻叶 25g 牡丹皮 20g 豨莶草 30g
钩藤 30g 川芎 20g 柴胡 20g
夏枯草 25g 蜈蚣 15g 白糖 30g
65%乙醇溶液 20gc
4、 一种降血压中药制剂的制备方法, 其特征在于, 其包括如下
1 )、 将石决明、 野菊花、 独活、 杜仲、 山楂、 益母草、 淫羊霍、 防己按比例配好, 经过粉碎机粉碎并过 80目筛, 然后在 50— 70°C的 高温下烘干, 然后自然晾到室温备用;
2 )、将上述步骤中石决明、野菊花、独活、杜仲、 山楂、益母草、 淫羊霍、 防己的粉末混合物加入纯净水煎煮三次, 第一次加入 10倍 量水煎煮半个小时, 第二次加入 5倍量水煎煮 20分钟, 第三次加入 5倍量水煎煮 10分钟, 然后合并煎液并过滤, 备用;
3 )、将罗布麻叶、牡丹皮、豨莶草、钩藤、川芎、柴胡、夏枯草、 蜈蚣按比例配好, 经过粉碎机粉碎并过 80目筛, 然后在 50— 70°C的 高温下烘干, 然后自然晾到室温备用;
4)、 将上述罗布麻叶、 牡丹皮、 豨莶草、 钩藤、 川芎、 柴胡、 夏 枯草、 蜈蚣的粉末混合物加入 10倍量的纯净水煎煮半个小时, 然后
取煎液并过滤, 备用;
5)、 在室温状态下, 将上述步骤 2 ) 和步骤 4) 中获得的煎液混 合, 并加入 65%乙醇溶液并搅拌均匀, 形成中药组合物溶液制剂; 6 )、 将上述步骤 5 ) 中的中药组合物溶液制剂加入白糖, 并搅拌 5分 钟, 即可制得, 制取的上述中药组合物溶液制剂可以用于口服, 如果 能够早中晚各饮用一次并长期饮用, 效果更好。
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