WO2014189130A1 - 細胞採取装置 - Google Patents

細胞採取装置 Download PDF

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Publication number
WO2014189130A1
WO2014189130A1 PCT/JP2014/063706 JP2014063706W WO2014189130A1 WO 2014189130 A1 WO2014189130 A1 WO 2014189130A1 JP 2014063706 W JP2014063706 W JP 2014063706W WO 2014189130 A1 WO2014189130 A1 WO 2014189130A1
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WO
WIPO (PCT)
Prior art keywords
cell collection
collection member
tube body
collection device
end side
Prior art date
Application number
PCT/JP2014/063706
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
典久 笹山
由以 萩原
友恵 森田
Original Assignee
ニプロ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ニプロ株式会社 filed Critical ニプロ株式会社
Priority to KR1020217016281A priority Critical patent/KR102351823B1/ko
Priority to JP2015518301A priority patent/JP6365534B2/ja
Priority to KR1020157035011A priority patent/KR102292694B1/ko
Publication of WO2014189130A1 publication Critical patent/WO2014189130A1/ja

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0291—Instruments for taking cell samples or for biopsy for uterus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B2010/0216—Sampling brushes

Definitions

  • the present invention relates to a cell collection device in which a cell collection member can be attached to and detached from the tip of a tube or a rod.
  • cervical cancer a method is used in which cells are collected from the cervix, and the collected cells are smeared on a slide glass and observed with a microscope. Such a diagnosis is called cervical cytology.
  • the collected cells are transported to an inspection center and observed at the inspection center.
  • a device in which a brush or the like is provided at the tip of a rod-shaped member is used (see Patent Document 1).
  • a brush or the like By rotating the rod-shaped member while the brush of the device is in contact with the cervix, cells of the cervix are collected by the brush or the like.
  • the cells are smeared by rubbing a brush or the like to which the cells are attached against the slide glass. Further, when an inspection is performed at the inspection center, only a portion such as a brush of the device is put into a container and conveyed to the inspection center by breaking a rod-shaped member.
  • a thin break point 16 is provided in the shaft portion 15 in order to put only a portion such as a brush of the device into the container. Therefore, the shaft portion 15 can be broken at the breaking point 16 and only the brush end portion can be put into the container. It is also conceivable to adopt a structure that can pull out a brush or the like from the tube.
  • the device when collecting cervical cells, the device is repeatedly moved or rotated in the insertion / removal direction.
  • the breaking point 16 may break in the vagina or the brush or the like may come off from the tube.
  • the present invention has been made in view of the above-described problems, and the object of the present invention is that the cell collection member does not come off the tube when collecting cells of the cervix, and can easily be removed after collection.
  • the object is to provide means that can be removed from the bar.
  • a cell collection device includes a tube having a first end and a second end, a cell collection member that can be attached to the first end of the tube, and the cell collection member that is attached to the tube.
  • a lock portion that holds the cell collection member attached to the first end, and a lock posture that holds the cell collection member attached to the first end of the tube, or the cell collection member of the tube body first.
  • an operation member that changes the posture of the lock portion in a release posture that is not held in a state of being attached to the end.
  • the operation member is configured to change the posture of the lock portion when the second end side is operated in a state of being inserted into the tubular body.
  • the cell collection device is used for collecting cervical cells in a state where the cell collection member is attached to the tube and the operation member is in the locked position. In this state, even if the cell collection member is fixed to the tube and the tube is moved in the longitudinal direction or rotated around the longitudinal direction, the cell collection member does not come off the tube. Further, since the operation member is operated on the second end side of the tubular body, even if an external force is applied to the first end side of the tubular body, the lock portion does not unexpectedly enter the release posture.
  • the lock member is changed from the locked position to the released position by operating the operation member on the second end side of the tubular body. Thereby, the cell collection member can be detached from the tube.
  • the lock portion may be provided on the operation member.
  • the cell collection member may have a deformable portion that can be elastically deformed, and the lock portion may press the deformable portion against the tubular body in a locked posture.
  • the cell collection member is fixed to the tube body by friction generated between the deformed portion pressed by the lock portion and the tube body. Since it is not necessary to provide a structure for engaging a claw or a hole in the cell collection member and the tube body, the structure is simplified.
  • the deformable portion may be engaged with the tubular body by being pressed by the lock portion.
  • the cell collection member is securely fixed to the tube body by the engagement between the deformed portion and the tube body.
  • the operation member may be held on the second end side of the tubular body by being screwed with the tubular body so that the lock portion is in a locked posture.
  • the operation member may be held on the second end side of the tubular body by being engaged with the tubular body so that the lock portion is in a locked posture.
  • the lock portion includes a fitting portion in which the cell collection member and the tubular body are fitted so as not to rotate around a virtual line passing through the first end and the second end, the operation member, and the cell. It may have a screwing portion with which the sampling member is screwed.
  • the rotation of the tube is transmitted to the cell collection member by the fitting portion, and the force in the direction in which the cell collection member is separated from the tube is transmitted by the screwing portion.
  • the force is transmitted from the tube body to the cell collection member separately in the fitting portion and the screwing portion, so that the load on the lock portion is reduced.
  • the lock portion includes a fitting portion in which the cell collection member and the tubular body are fitted around the imaginary line passing through the first end and the second end so as not to be mutually rotatable, the operation member, and the cell. And an engaging portion that engages with the sampling member.
  • the rotation of the tube is transmitted to the cell collection member by the fitting portion, and the force in the direction in which the cell collection member is separated from the tube is transmitted by the engagement portion.
  • the force is transmitted from the tubular body to the cell collection member separately in the fitting portion and the engaging portion, so that the load on the lock portion is reduced.
  • the engagement portion engages with the cell collection member in a locked posture at the first rotation position of the operation member around the imaginary line passing through the first end and the second end, and the second rotation position It may be in a release posture and not engaged with the cell collection member.
  • the present invention relates to a cell collection device in which an engagement portion is provided on one of a rod and a cell collection member, and the cell collection member can be attached to and detached from the tip of the rod.
  • the engaging portion protrudes toward the outside of the rod or the cell collection member, and a protrusion or a recess extending along the longitudinal direction of the rod or the cell collection member, and is released from the engagement posture.
  • a claw that is exposed on the outer surface of the rod or the cell collection member and is pressed to change the position of the claw from the engaged position to the released position.
  • a cylindrical part in which the convex part or concave part and the claw can be inserted into an internal space, a concave part or convex part in which the convex part or concave part can be inserted, and the cylindrical part A hole that is provided on the peripheral wall and that can be engaged by inserting the claw in the engaging posture is provided.
  • the cell collection device is used in a state in which a cell collection member is attached to a rod for collecting cervical cells.
  • the convex portion or concave portion of the engaging portion and the claw are inserted into the internal space of the cylindrical portion, the convex portion is inserted into the concave portion, and the claw is engaged with the hole in the peripheral wall, whereby the cell collection member is It is fixed with respect to the material with respect to the longitudinal direction and the direction of rotation about the longitudinal direction.
  • the nail in the engaged posture is changed to the released posture by pressing the pressing portion.
  • position remove
  • a pair of the claw, the pressing portion, and the hole is provided at a position that is symmetric with respect to a center line along the longitudinal direction of the rod or the cell collection member.
  • the recess may be disposed on the center line.
  • the pair of the nail, the pressing portion, and the hole is provided at a position that is symmetric with respect to the center line along the longitudinal direction of the rod or the cell collection member, external force is applied to both pressing portions at once. Less likely to join.
  • the engaging portion may be provided on the bar.
  • the convex portion may be provided on the bar.
  • the convex portion has a tapered shape that tapers toward the tip, and in a state where the cell collection member is attached to the tip of the rod, the tapered surface presses against the concave portion. Also good.
  • the force of the practitioner pressing and rotating the bar material is transmitted to the cell collection member by the press contact between the tapered surface of the convex portion and the concave portion, and these forces are transmitted to the engagement portion between the nail and the hole of the peripheral wall.
  • the load is not.
  • the posture of the lock portion that holds the tubular body and the cell collection member is changed.
  • the cell collection member is not detached from the tube, and the cell collection member is easily removed from the tube after collection.
  • the cell collection member is inserted into the rod when collecting cells of the cervix by inserting the projection into the recess and engaging the claw in the engagement posture with the hole in the peripheral wall of the cylindrical portion.
  • the cell collection member is easily detached from the rod after collection without being detached from the material.
  • FIG. 1 is a perspective view showing an external configuration of a cell collection device 10 according to the first embodiment.
  • FIG. 2 is a perspective view showing an external configuration of the tube body 11.
  • FIG. 3 is a perspective view showing an external configuration of the cell collection member 12.
  • FIG. 4 is a perspective view showing an external configuration of the operation member 13.
  • FIG. 5 is an enlarged cross-sectional view showing a cross section including the center line 102 of the cell collection device 10.
  • FIG. 6 is an enlarged cross-sectional view of the cell collection device 10 in a state where the elastic pieces 42 and 43 are changed to the release posture.
  • FIG. 7 is a perspective view showing an external configuration of the cell collection device 50 according to the second embodiment.
  • FIG. 8 is a perspective view showing an external configuration of the tubular body 51.
  • FIG. 9 is a perspective view showing an external configuration of the cell collection member 52.
  • FIG. 10 is a perspective view showing an external configuration of the operation member 53.
  • 11 is a cross-sectional view showing a XI-XI cross section of FIG.
  • FIG. 12 is an enlarged cross-sectional view showing a cross section including the center line 102 of the cell collection device 50.
  • FIG. 13 is an enlarged cross-sectional view of the cell collection device 50 showing a process in which the male screw portion 61 changes its posture to the release posture.
  • FIG. 14 is a perspective view showing the vicinity of the engaging portion 72 of the cell collection device 70 according to a modification of the second embodiment.
  • FIG. 15 is an enlarged cross-sectional view showing a cross section including the center line 102 of the cell collection device 70.
  • FIG. 16 is an enlarged cross-sectional view of the cell collection device 70 in a state in which the engagement portion 72 is changed in the release posture.
  • FIG. 17 is a perspective view showing an external configuration of the cell collection device 80 according to the third embodiment.
  • FIG. 18 is a perspective view showing the external configuration of the tube body 81 and the cap 84.
  • FIG. 19 is a perspective view showing an external configuration of the cell collection member 52.
  • FIG. 20 is a perspective view showing an external configuration of the operation member 53.
  • FIG. 21 is an enlarged cross-sectional view showing a cross section including the center line 102 of the cell collection device 50.
  • FIG. 22 is an enlarged cross-sectional view of the cell collection device 80 in a state in which the lock unit 96 is changed to the release posture.
  • FIG. 23 is a cross-sectional view showing a modification of the fourth embodiment.
  • FIG. 24 is a cross-sectional view showing a release posture in a modification of the fourth embodiment.
  • FIG. 25 is a perspective view showing an external configuration of the cell collection device 110 according to the fifth embodiment.
  • FIG. 26 is a perspective view showing the external configuration of the tube body 111, the operation member 113, and the coil spring 131.
  • FIG. 27 is a perspective view showing an external configuration of the cell collection member 112.
  • FIG. 28 is a perspective view showing an external configuration of the lock member 114.
  • FIG. 29 is an enlarged cross-sectional view showing a cross section including the center line 102 of the cell collection device 110.
  • FIG. 30 is an enlarged cross-sectional view of the cell collection device 110 in a state where the lock member 114 is changed to the release posture.
  • FIG. 31 is a perspective view showing an external configuration of a cell collection device 150 according to the sixth embodiment.
  • FIG. 32 is a perspective view showing an external configuration of the tubular body 151.
  • FIG. 33 is a perspective view showing an external configuration of the cell collection member 152.
  • FIG. 34 is a perspective view showing an external configuration of the operation member 153.
  • FIG. 35 is a cross-sectional view taken along the line VV of FIG.
  • FIG. 36 is an enlarged cross-sectional view of the cell collection device 150 showing a cross section including the center line 102 of the cell collection device 150.
  • FIG. 31 is a perspective view showing an external configuration of a cell collection device 150 according to the sixth embodiment.
  • FIG. 32 is a perspective view showing an external configuration of the tubular body 151.
  • FIG. 33 is a perspective view showing an external configuration of the cell collection
  • FIG. 37 is an enlarged cross-sectional view of the cell collection device 150 showing the process of changing the posture of the male screw portion 161 to the release posture.
  • FIG. 38 is a perspective view showing an external configuration of the cell collection device 210 according to the seventh embodiment.
  • FIG. 39 is a perspective view showing an external configuration of the bar 211.
  • FIG. 40 is a perspective view showing an external configuration of the cell collection member 212.
  • FIG. 41 is an enlarged cross-sectional view showing a cross section including the center line 102 of the cell collection device 210.
  • FIG. 42 is an enlarged cross-sectional view of the cell collection device 210 in a state where the claws 222 and 223 are changed to the release posture.
  • FIG. 43 is an enlarged cross-sectional view showing a modification in which the bar 211 is provided with a recess 246 and the cell collection member 212 is provided with a protrusion 221.
  • 44 is an enlarged cross-sectional view showing a modification in which only one of the pair of claws 222 and 223, the pressing portions 224 and 225, and the holes 249 and 250 is provided.
  • FIG. 45 is an enlarged cross-sectional view of a modified example in which a coil spring 235 is provided in the recess 246 of the cell collection member 212.
  • FIG. 46 is an enlarged cross-sectional view showing a release state of a modified example in which the coil spring 235 is provided in the concave portion 246 of the cell collection member 212.
  • FIG. 47 is an exploded perspective view showing a modified example of the cell collection device 210.
  • FIG. 48 is an exploded perspective view showing a modified example of the cell collection device 210.
  • 49A is a view of the rod 211 in the modification of the cell collection device 210 as viewed along the center line 102 of the convex portion 221, and
  • FIG. 49A is a modification of the cell collection device 210.
  • FIG. 6 is a view of the concave portion 246 of the cell collection member 212 in FIG.
  • FIG. 50A is an enlarged cross-sectional view along the vertical direction (direction in which the pressing portions 224 and 225 are provided) showing a state where the cap 300 is attached in the modification of the cell collection device 210.
  • FIG. B) is an enlarged cross-sectional view along the left-right direction (direction in which the pressing portions 224 and 225 are not provided) showing a state in which the cap 300 is attached in the modification of the cell collection device 210.
  • FIG. FIG. 51A is an enlarged cross-sectional view along the vertical direction (the direction in which the pressing portions 224 and 225 are provided) showing a state where the cap 300 is attached in the modification of the cell collection device 210.
  • FIG. B) is an enlarged cross-sectional view along the left-right direction (direction in which the pressing portions 224 and 225 are not provided) showing a state in which the cap 300 is attached in the modification of the cell collection device 210.
  • FIG. 51A is an enlarged cross-sectional view along the vertical direction (the direction in which the pressing portions 224 and 225 are provided) showing a state where the cap 300 is attached in the modification of the cell collection device 210.
  • FIG. B) is an enlarged cross-sectional view along the left-right direction (
  • FIG. 52A is an enlarged cross-sectional view along the vertical direction (direction in which the pressing portions 224 and 225 are provided) showing a state where the cap 300 is attached in the modification of the cell collection device 210.
  • FIG. B) is an enlarged cross-sectional view along the left-right direction (direction in which the pressing portions 224 and 225 are not provided) showing a state in which the cap 300 is attached in the modification of the cell collection device 210.
  • FIG. 53A is an enlarged cross-sectional view along the vertical direction (the direction in which the pressing portions 224 and 225 are provided) showing a state where the cap 300 is attached in the modification of the cell collection device 210.
  • FIG. B) is an enlarged cross-sectional view along the left-right direction (direction in which the pressing portions 224 and 225 are not provided) showing a state in which the cap 300 is attached in the modification of the cell collection device 210.
  • FIG. 54A is an enlarged cross-sectional view along the vertical direction (direction in which the pressing portions 224 and 225 are provided) showing a state where the cap 300 is attached in the modification of the cell collection device 210.
  • FIG. B) is an enlarged cross-sectional view along the left-right direction (direction in which the pressing portions 224 and 225 are not provided) showing a state in which the cap 300 is attached in the modification of the cell collection device 210.
  • FIG. 54A is an enlarged cross-sectional view along the vertical direction (direction in which the pressing portions 224 and 225 are provided) showing a state where the cap 300 is attached in the modification of the cell collection device 210.
  • FIG. B) is an enlarged cross-sectional view along the left-right direction (direction
  • the cell collection device 10 includes a tube body 11, a cell collection member 12, and an operation member 13.
  • the cell collection member 12 is detachably attached to the distal end side of the tube body 11.
  • the operation member 12 is inserted into the tube body 11.
  • the direction in which the elongated tube 11 extends is referred to as the longitudinal direction 101.
  • a virtual line passing through the center of the tube body 11 along the longitudinal direction 101 is referred to as a center line 102.
  • a direction of rotation about the center line 102 is referred to as a rotation direction 103.
  • the side of the practitioner is referred to as the proximal end side (right side in FIG.
  • the distal end of the tubular body 11 corresponds to the first end, and the proximal end of the tubular body 11 corresponds to the second end.
  • the tube body 11 is a member having a circular tube shape that is elongated in the longitudinal direction 101.
  • the tube body 11 is open at the front end and the rear end, and the internal space is continuous between the front end and the rear end.
  • the tube 11 is formed as a molded product of synthetic resin, for example.
  • the material and shape of the tube body 11 are not particularly limited, and for example, the outer shape may be a polygonal shape.
  • the external dimensions of the tube 11 and the length in the longitudinal direction 101 are optimally set so that the practitioner has the proximal end side and allows the cell collection member 12 to reach the cervix.
  • holes 20 and 21 are provided on the distal end side of the tube body 11.
  • the holes 20 and 21 penetrate the wall of the tubular body 11 in the radial direction on the distal end side of the tubular body 11.
  • the holes 20 and 21 have a quadrangular shape formed by their peripheral edges.
  • the holes 20 and 21 are arranged as a pair at positions symmetrical with respect to the center line 102.
  • a female screw 22 is formed on the inner wall on the proximal end side of the tube body 11.
  • the female screw 22 is screwed with the male screw 33 of the operation member 13.
  • the cell collection member 12 includes a main body 40, a brush 41, and elastic pieces 42 and 43.
  • the main body 40 is, for example, a synthetic resin molded product.
  • the brush 41 is inserted into a hole 44 formed on the front end side of the main body 40 and fixed by an adhesive or the like.
  • the brush 41 has a plurality of synthetic resin fibers fixed to a stainless steel shaft.
  • a known one such as an elastomer molded product may be employed. Therefore, as in this embodiment, the shaft may extend along the center line 102 of the tube body 11, and the fibers may expand radially from the shaft, or other shapes may be employed. Also good.
  • the main body 40 has a generally cylindrical outer shape. Protrusions 48 and 49 projecting from the surface of the base end side of the main body 40 are provided.
  • the convex portions 48 and 49 each have a semi-cylindrical shape. The diameter of the circle along the outer peripheral surface of the convex portions 48 and 49 is slightly smaller than the inner diameter of the tube body 11.
  • the elastic pieces 42 and 43 protrude from the base end side surface of the main body 40.
  • Each of the elastic pieces 42 and 43 has a thin plate shape that can be elastically deformed, and is disposed at a position that is symmetrical with respect to the center line 102 with the front and back surfaces facing each other in parallel.
  • the elastic pieces 42 and 43 have claws 45 and 46 at their protruding ends.
  • the claws 45 and 46 protrude outward from the elastic pieces 42 and 43, respectively, away from the center line 102.
  • the claws 45 and 46 have a size and shape that can enter the holes 20 and 21 of the tube body 11.
  • the distance between the tips of the claws 45 and 46 is shorter than the inner diameter of the tube body 11. Therefore, in a state where the elastic pieces 42 and 43 are not elastically deformed, the elastic pieces 42 and 43 enter the opening at the tip of the tube body 11 without being pressed against the peripheral edge of the opening or the inner wall of the tube body 11. And can leave. That is, in a state where the elastic pieces 42 and 43 are not elastically deformed, the cell collection member 12 attached to the tip of the tube body 11 has the cell collection member 12 on the lower side and the longitudinal direction 101 of the tube body 11 is in the gravity direction. If it is in the state along, it will easily fall out of the tube 11 by gravity.
  • the elastic pieces 42 and 43 correspond to the deformed portion.
  • a hole 47 extending toward the distal end side along the center line 102 is formed between the elastic pieces 42 and 43 on the base end side of the main body 40.
  • the hole 47 has a cylindrical shape and is an operation member described later.
  • the tip portions of the 13 lock portions 31 can enter.
  • the operation member 13 includes a rod part 30, a lock part 31, and a knob part 32.
  • the rod portion 30 is a substantially cylindrical member that is elongated in the longitudinal direction 101.
  • the rod portion 30 has an outer diameter that can be inserted into the internal space of the tube body 11, and the length in the longitudinal direction 101 is the same as or slightly shorter than the length of the tube body 11 in the longitudinal direction 101.
  • the rod portion 30 may have a plurality of elongated grooves formed in the longitudinal direction 101 in order to reduce the amount of resin.
  • a lock portion 31 is provided on the distal end side of the operation member 13.
  • the lock portion 31 is formed integrally with the rod portion 30, and is a portion that is tapered in a tapered shape on the distal end side of the rod portion 30.
  • the distal end of the lock portion 31 has an outer diameter that can enter the hole 47 from between the elastic pieces 42 and 43 of the cell collection member 12.
  • the proximal end side of the lock portion 31 is continuous with the outer peripheral surface of the rod portion 30, and the outer diameter thereof is larger than the distance between the surfaces where the elastic pieces 42 and 43 face each other.
  • a knob portion 32 is provided at the proximal end of the rod portion 30.
  • the knob portion 32 has a cylindrical shape having an outer diameter larger than the outer diameter of the rod portion 30 and the inner diameter of the tube body 11.
  • the outer diameter of the rod portion 30 is slightly smaller than the inner diameter of the tube body 11.
  • a plurality of concave grooves along the longitudinal direction are formed on the outer peripheral surface of the knob portion 32 at intervals in the circumferential direction to prevent slipping.
  • a male screw 33 is formed on the outer peripheral surface of the base end portion of the rod portion 30.
  • the male screw 33 is such that the rod portion 30 is inserted into the internal space of the tube body 11 and is screwed into the female screw 22 of the tube body 11.
  • the cell collection device 10 is used, for example, in the collection of cervical cells, with the cell collection member 12 mounted on the tube 11 and the operation member 13 having the lock portion 31 in the locked posture.
  • the lock portion 31 is in the locked posture
  • the cell collection member 12 is fixed with respect to the tube body 11 in the longitudinal direction 101 and the rotation direction 103. Therefore, when the practitioner holds the proximal end side of the tube body 11 and performs operations such as pushing and pulling and rotating, the force is transmitted to the cell collection member 12, and the cell collection member 12 is integrated with the tube body 11. Move or rotate.
  • the operation member 13 in a state where the cell collection member 12 is attached to the distal end of the tube body 11, the operation member 13 is inserted from the proximal end, and the male screw 33 of the operation member 13 and the female screw of the tube body 11.
  • the lock portion 31 of the operation member 13 is in the most advanced state on the distal end side of the tube body 11.
  • the tip of the lock portion 31 has entered the hole 47 of the cell collection member 12.
  • the peripheral surface of the lock portion 31 enters between the elastic pieces 42 and 43 of the cell collection member 12 and elastically deforms the claw 45 and 46 side of the elastic pieces 42 and 43 outwardly away from the center line 102.
  • the operating member 13 does not move in the longitudinal direction 101 with respect to the tube body 11 unless the male screw 33 and the female screw 22 are unscrewed.
  • the elastic pieces 42 and 43 are pressed outward by the lock portion 31 and elastically deformed, and the claws 45 and 46 enter the holes 20 and 21 of the tube body 11, respectively. Further, the thin plate portions of the elastic pieces 42 and 43 closer to the main body 40 than the claws 45 and 46 are sandwiched between the lock portion 31 and the peripheral edges of the holes 20 and 21 of the tube body 11. It will be in the state pressed.
  • the elastic pieces 42 and 43 move along the longitudinal direction 101 with respect to the tube body 11 or rotate. There is no rotation along the direction 103.
  • the elastic pieces 42 and 43 are moved along the longitudinal direction 101 with respect to the tube body 11 by the engagement between the claws 45 and 46 and the holes 20 and 21. It is prevented from moving or rotating along the rotation direction 103.
  • the posture of the lock portion 31 that elastically deforms the elastic pieces 42 and 43 corresponds to the lock posture.
  • the operator holds the knob 32 of the operation member 13 and the proximal end side of the tube 11, and the knob 32 is located with respect to the tube 11. Is rotated. Thereby, the screwing of the female screw 22 of the tube 11 and the male screw 33 of the operation member 13 is released. Then, as the operation member 13 is moved in the direction of being pulled out from the proximal end of the tube body 11, the lock portion 31 is separated from the elastic pieces 42 and 43 of the cell collection member 12. When the lock portion 31 is no longer pressed, the elastic pieces 42 and 43 are elastically restored to the original state. That is, the distance between the tips of the claws 45 and 46 is shorter than the inner diameter of the tube body 11. Thus, the posture of the lock portion 31 (the position in the longitudinal direction 101 in this embodiment) at which the elastic pieces 42 and 43 are not elastically deformed corresponds to the release posture.
  • the elastic pieces 42 and 43 that have returned to the original state can enter and exit the opening at the tip of the tube body 11 without being pressed against the periphery of the opening or the inner wall of the tube body 11. Therefore, the cell collection member 12 attached to the tip of the tube body 11 can be easily formed by gravity when the longitudinal direction 101 of the tube body 11 is along the gravity direction with the cell collection member 12 on the lower side. Drop off 11 The dropped cell collection member 12 is accommodated in a storage container (not shown).
  • the cell collection member 12 in collecting cervical cells, the cell collection member 12 is attached to the tube 11, and the cell collection member 12 is fixed to the tube 11 by the lock portion 31 of the operation member 13. Even if the tube body 11 is moved in the longitudinal direction 101 or rotated in the rotation direction 103, the cell collection member 12 is not detached from the tube body 11.
  • the operation member 13 since the operation member 13 is operated on the proximal end side of the tube body 11, even if an external force is applied to the distal end side of the tube body 11, the lock portion 31 does not move (posture change) unexpectedly.
  • the operation member 13 is operated on the proximal end side of the tube body 11 so that the lock unit 31 moves (posture change), and the cell collection member 12 moves to the tube body. 11 can be removed.
  • the lock part 31 is provided in the operation member 13, the number of parts of the cell collection device 10 is reduced and the device structure is simplified.
  • the cell collection member 12 includes elastic pieces 42 and 43 that can be elastically deformed. Since the lock portion 31 presses the elastic pieces 42 and 43 against the tube body 11, the cell collection member 12 is pressed by the lock portion 31. The cell collection member 12 is fixed to the tube body 11 by friction generated between the elastic pieces 42 and 43 and the tube body 11. In the present embodiment, the elastic pieces 42 and 43 are provided with the claws 45 and 46, but even if the claws 45 and 46 are not provided, the cell collection member 12 is fixed to the tubular body 11. By not providing the nails 45 and 46, the structure of the cell collection device 10 is simplified.
  • the claws 45 and 46 of the elastic pieces 42 and 43 are engaged with the holes 20 and 21 of the tube body 11 by being pressed by the lock portion 31, so that the cell collection member 12 is securely fixed to the tube body 11.
  • the operation member 13 is held on the proximal end side of the tube body 11 so as not to move in the longitudinal direction 101 with respect to the tube body 11 by screwing the female screw 22 and the male screw 33, the operation member 13 is operated unexpectedly. It is prevented that the member 13 moves in the longitudinal direction 101 and the cell collection member 12 is detached from the tube body 11.
  • the cell collection device 50 includes a tube body 51, a cell collection member 52, and an operation member 53.
  • the cell collection member 52 is detachably attached to the distal end side of the tube body 51.
  • the operation member 53 is inserted into the tube body 51.
  • the direction in which the elongated tube 51 extends is referred to as the longitudinal direction 101.
  • a virtual line passing through the center of the tubular body 51 along the longitudinal direction 101 is referred to as a center line 102.
  • a direction of rotation about the center line 102 is referred to as a rotation direction 103.
  • the side of the practitioner is referred to as a proximal end side (right side in FIG.
  • the distal end of the tubular body 51 corresponds to the first end, and the proximal end of the tubular body 51 corresponds to the second end.
  • the tube body 51 is a tubular member having a long and narrow outer shape in the longitudinal direction 101.
  • the tube body 51 has an opening at the front end and a rear end, and a circular internal space is continuous between the front end and the rear end.
  • the tubular body 51 is formed, for example, as a synthetic resin molded product.
  • the material and shape of the tubular body 51 are not particularly limited, and for example, the outer shape may be a cylindrical shape.
  • the outer dimensions of the tube 51 and the length in the longitudinal direction 101 are optimally set so that the practitioner has the proximal end side and allows the cell collection member 52 to reach the cervix.
  • a groove 54 is provided on the surface of the tube body 51 on the tip side.
  • the groove 54 is recessed in the longitudinal direction from the surface on the distal end side of the tubular body 51, and has a hexagonal shape along the outer shape of the tubular body 51 as viewed from the viewpoint along the center line 102.
  • the convex piece 58 of the cell collection member 52 is inserted in the groove 54. Therefore, the depth along the center line 102 of the groove 54 is approximately the same as the dimension of the convex piece 58 protruding from the main body 55 along the center line 102 in the cell collection member 52.
  • the cell collection member 52 has a main body 55 and a brush 56.
  • the main body 55 is, for example, a synthetic resin molded product.
  • the brush 56 is inserted into a hole 57 formed on the distal end side of the main body 55 and fixed by an adhesive or the like.
  • the brush 56 has a plurality of synthetic resin fibers fixed to a stainless steel shaft.
  • a known one such as an elastomer molded product may be employed. Therefore, as in this embodiment, the shaft may extend along the center line 102 of the tube body 51, and the fibers may expand radially from the shaft, or other shapes may be employed. Also good.
  • the main body 55 has a generally hexagonal cylindrical shape. On the surface on the base end side of the main body 55, a convex piece 58 protruding from the surface is provided.
  • the convex piece 58 protrudes along the center line 102 from the base end side surface of the main body 55, and has a hexagonal shape when viewed from the viewpoint along the center line 102.
  • the dimension that the protruding piece 58 protrudes from the main body 55 along the center line 102 is approximately the same as the dimension along the center line 102 of the male screw portion 61 of the operation member 53 described later.
  • the thickness of the convex piece 58 is set so that it can be inserted into the groove 54 of the tubular body 51.
  • the convex piece 58 is inserted into the groove 54 of the tubular body 51, and the surface on the proximal end side of the main body 55 and the surface on the distal end side of the tubular body 51 come into contact with each other. It is positioned and mounted at a position where the axes match. By fitting the convex piece 58 and the groove 54, the main body 55 does not rotate in the rotation direction 103 with respect to the tubular body 51.
  • the groove 54 and the convex piece 58 correspond to the fitting portion.
  • a screw hole 59 extending to the distal end side along the center line 102 is formed inside the convex piece 58 on the base end side of the main body 55.
  • the screw hole 59 has a cylindrical shape, and will be described later. It is threadedly engaged with the male screw part 61 of 53.
  • the depth along the center line 102 of the screw hole 59 is approximately the same as the dimension along the center line 102 of the male screw portion 61 of the operation member 53 described later.
  • the operation member 53 includes a rod portion 60, a male screw portion 61, and a knob portion 62.
  • the rod portion 60 is a substantially cylindrical member that is elongated in the longitudinal direction 101.
  • the rod portion 60 has an outer diameter that can be inserted into the internal space of the tubular body 51, and the length in the longitudinal direction 101 is slightly longer than the length in the longitudinal direction 101 of the tubular body 51.
  • a male screw 61 is provided on the distal end side of the operation member 53.
  • the male screw portion 61 is integrally formed on the distal end side of the rod portion 60.
  • the male screw part 61 can enter and screw into the screw hole 59 of the cell collection member 52.
  • the male screw part 61 corresponds to a lock part and a screwing part.
  • the posture in which the male screw portion 61 is screwed into the screw hole 59 corresponds to the lock posture, and the posture in which the male screw portion 61 is extracted from the screw hole 59 corresponds to the release posture.
  • a knob portion 62 is provided at the proximal end of the rod portion 60.
  • the knob portion 62 has a hexagonal column shape whose outer diameter is larger than the outer diameter of the rod portion 60 and the inner diameter of the tube body 51.
  • the outer diameter of the rod portion 60 is slightly smaller than the inner diameter of the tube body 51.
  • the cell collection device 50 is used, for example, in the collection of cervical cells, with the cell collection member 52 attached to the tube 51 and the male screw portion 61 of the operation member 53 screwed into the screw hole 59.
  • the male screw portion 61 is in the locked posture, the cell collection member 52 is fixed with respect to the tube body 51 in the longitudinal direction 101 and the rotation direction 103. Therefore, when the practitioner holds the proximal end side of the tube body 51 and performs operations such as pushing and pulling and rotating, the force is transmitted to the cell collection member 52, and the cell collection member 52 is integrated with the tube body 51. Move or rotate.
  • the convex piece 58 of the cell collection member 52 and the groove 54 of the tube 51 are fitted. Thereby, the cell collection member 52 does not rotate in the rotation direction 103 with respect to the tube body 51. Further, the operation member 53 is inserted from the base end, and the male screw portion 61 of the operation member 53 is screwed into the screw hole 59 of the cell collection member 52. Thereby, the cell collection member 52 does not move in the longitudinal direction 101 with respect to the tube body 51.
  • the operator holds the knob 62 of the operation member 53 and the proximal end side of the tube 51, and the knob 62 is attached to the tube 51. Is rotated. Thereby, the male screw portion 61 of the operation member 53 is extracted from the screw hole 59 of the cell collection member 52.
  • the cell collection member 52 attached to the tip of the tube body 51 is easily pulled by gravity when the longitudinal direction 101 of the tube body 51 is along the gravity direction with the cell collection member 52 on the lower side. Fall out of 51.
  • the dropped cell collection member 52 is accommodated in a storage container (not shown).
  • the operation member 53 is held by the user so that the relative position along the center line 102 between the tube 51 and the operation member 53 does not change. Then, the male thread portion 61 of the operation member 53 comes out from the screw hole 59 of the cell collection member 52, the cell collection member 52 moves away from the tip of the tube body 51, and the convex piece 58 comes out of the groove 54.
  • the rotation of the tube 51 is transmitted to the cell collection member 52 by the fitting of the groove 54 of the tube 51 and the convex piece 58 of the cell collection member 52, and the screw hole 59 of the cell collection member 52 and the male of the operation member 53.
  • a force in a direction in which the cell collection member 52 is separated from the tube body 51 is transmitted by screwing with the screw portion 61 or contact between the tip of the tube body 51 and the main body 55 of the cell collection member 52. Since the force is transmitted from the tube body 51 to the cell collection member 52 by being divided into such fitting and screwing, the load on each member constituting the cell collection device 50 is reduced.
  • an engagement hole 71 is provided instead of the screw hole 59 of the cell collection member 52, and the operation member 53 is provided.
  • the other structure is the same except that an engaging portion 72 is provided instead of the male screw portion 61.
  • the engagement hole 71 and the engagement portion 72 will be described in detail.
  • members having the same reference numerals as those assigned to the cell collection device 50 according to the second embodiment are members similar to those of the cell collection device 50.
  • an engagement hole 71 extending toward the distal end side along the center line 102 is formed on the inner side of the convex piece 58 on the base end side of the main body 55 of the cell collection member 52. ing.
  • the engagement hole 71 is generally cylindrical.
  • convex portions 73 and 74 projecting inwardly toward the opening, that is, inwardly approaching the center line 102 are provided at symmetrical positions with the center line 102 as the center.
  • the convex portions 73 and 74 project so as to narrow the inner diameter of the engagement hole 71. Further, a space is formed between the convex portions 73 and 74 so as to continue to the back side of the engagement hole 71 (the front end side of the main body 55).
  • An engaging portion 72 is provided on the distal end side of the operation member 53.
  • the engaging portion 72 is integrally formed on the distal end side of the rod portion 60.
  • the engaging portion 72 has a small diameter portion 75 and wing pieces 76 and 77.
  • the small diameter portion 75 has an outer diameter smaller than the outer diameter of the rod portion 60, and can enter between the convex portions 73 and 74 of the engagement hole 71 along the center line 102.
  • wing pieces 76 and 77 are provided at symmetrical positions around the center line 102. Wings 76 and 77 protrude outwardly away from center line 102.
  • Each of the wing pieces 76 and 77 has a partial circular shape, and has a size and a shape capable of entering the space between the convex portions 73 and 74 of the engagement hole 71.
  • the surfaces on the rod part 60 side in the blade pieces 76 and 77 are inclined surfaces 78 and 79 that are inclined in a direction approaching the rod part 60. The blade pieces 76 and 77 can enter the engagement hole 71 and engage with the convex portions 73 and 74.
  • the convex piece 58 of the cell collection member 52 and the groove 54 of the tube body 51 are fitted in a state where the cell collection member 52 is attached to the tip of the tube body 51. Thereby, the cell collection member 52 does not rotate in the rotation direction 103 with respect to the tube body 51.
  • the operation member 53 is inserted from the proximal end, and the engagement portion 72 of the operation member 53 is engaged with the engagement hole 71 of the cell collection member 52.
  • the operating member 53 is positioned at the second rotational position where the engaging portion 72 and the blade pieces 76 and 77 are located between the convex portions 73 and 74 of the engaging hole 71.
  • the In the second rotational position the engaging portion 72 of the operating member 53 inserted into the tubular body 51 from the proximal end side of the tubular body 51 is engaged with the blade pieces 76 and 77 through the space between the convex portions 73 and 74. It enters the back (front end side) of the hole 71.
  • the blade pieces 76 and 77 move to positions where they come into contact with the convex portions 73 and 74.
  • the inclined surfaces 78 and 79 of the blade pieces 76 and 77 abut against the convex portions 73 and 74, and are guided by the inclined surfaces 78 and 79, so that the engaging portion 72 comes into contact with the inner surface of the engaging hole 71. Thereby, the operation member 53 cannot be rotated beyond the first rotation position. Due to the engagement between the engagement portion 72 and the engagement hole 71, the cell collection member 52 does not move in the longitudinal direction 101 with respect to the tube body 51. The engaging portion 72 at the first rotational position is in the locked posture, and the engaging portion 72 at the second rotational position is in the released posture.
  • the operator holds the knob 62 of the operation member 53 and the proximal end side of the tube 51, and the knob 62 is attached to the tube 51. And rotated from the first rotation position to the second rotation position. Then, when the knob portion 62 is slightly pulled away from the tube body 51, the engaging portion 72 of the operation member 53 is extracted from the engaging hole 71 of the cell collection member 52.
  • the cell collection member 52 attached to the tip of the tube body 51 is easily pulled by gravity when the longitudinal direction 101 of the tube body 51 is along the gravity direction with the cell collection member 52 on the lower side. Fall out of 51.
  • the dropped cell collection member 52 is accommodated in a storage container (not shown).
  • the knob portion 62 of the operation member 53 is merely rotated about 90 °, so that the engagement portion 72 changes its posture with a simple operation. .
  • the cell collection device 80 includes a tube body 81, a cell collection member 82, an operation member 83, and a cap 84.
  • the cell collection member 82 is detachably attached to the distal end side of the tube body 81.
  • the cell collection member 82 is inserted into the tube body 81.
  • the cap 84 is attached to the proximal end side of the tubular body 81.
  • the direction in which the elongated tube 81 extends is referred to as the longitudinal direction 101.
  • a virtual line passing through the center of the tubular body 81 along the longitudinal direction 101 is referred to as a center line 102.
  • a direction of rotation about the center line 102 is referred to as a rotation direction 103.
  • the side of the practitioner is referred to as the proximal side (the right side in FIG. 17), and the side to which cell collection member 82 is attached is referred to as the distal side (the left side in FIG. 17).
  • the distal end of the tubular body 81 corresponds to the first end, and the proximal end of the tubular body 81 corresponds to the second end.
  • the tube body 81 is a member having an elongated outer shape in the longitudinal direction 101.
  • the tubular body 81 has an opening at the front end and a rear end, and a circular internal space is continuous between the front end and the rear end.
  • the tubular body 81 is formed, for example, as a synthetic resin molded product.
  • the material and shape of the tubular body 81 are not particularly limited, and for example, the outer shape may be a polygonal shape.
  • the outer dimensions of the tube 81 and the length in the longitudinal direction 101 are optimally set so that the practitioner holds the proximal end side and allows the cell collection member 82 to reach the cervix.
  • a male screw portion 85 is provided on the outer peripheral surface of the proximal end side of the tube body 81.
  • a cap 84 is attached to the male screw portion 85.
  • the cap 84 has a cylindrical shape that can cover the proximal end side of the tubular body 81, and closes the opening on the proximal end side of the tubular body 81.
  • an internal thread portion 86 is formed on the inner peripheral surface of the cap 84.
  • the female screw portion 86 and the male screw portion 85 are screwed together, and the proximal end of the tube body 81 is covered and closed by the cap 84.
  • a groove 87 is provided on the surface of the tube 81 on the tip side.
  • the groove 87 is recessed in the longitudinal direction from the surface on the distal end side of the tubular body, and has a circular shape along the outer shape of the tubular body 51 as viewed from the viewpoint along the center line 102.
  • the convex piece 91 of the cell collection member 82 is inserted.
  • a large-diameter portion 95 having an enlarged internal space is formed on the distal end side of the tube body 81.
  • the large diameter portion 95 is formed slightly on the proximal end side from the distal end of the tube body 81.
  • the large-diameter portion 95 has a shape in which the central portion in the longitudinal direction 101 has the largest inner diameter, and the inner diameter decreases in a tapered shape toward the distal end side and the proximal end side.
  • the cell collection member 82 has a main body 88 and a brush 89.
  • the main body 88 is, for example, a synthetic resin molded product.
  • the brush 89 is inserted into a hole 90 formed on the front end side of the main body 88 and fixed by an adhesive or the like.
  • the brush 89 has a plurality of synthetic resin fibers fixed to a stainless steel shaft.
  • a known one such as an elastomer molded product may be employed. Therefore, as in this embodiment, the shaft may extend along the center line 102 of the tube body 81, and the fibers may spread radially from the shaft, or other shapes may be employed. Also good.
  • the main body 88 has a substantially cylindrical outer shape. On the base end side surface of the main body 88, a convex piece 91 protruding from the surface is provided.
  • the convex piece 91 protrudes along the center line 102 from the base end side surface of the main body 88 and has a circular shape when viewed from the viewpoint along the center line 102.
  • the thickness of the convex piece 91 is set so that it can be inserted into the groove 87 of the tubular body 81.
  • the convex piece 91 is inserted into the groove 87 of the tubular body 81, and the surface on the proximal end side of the main body 88 and the surface on the distal end side of the tubular body 81 come into contact with each other. It is positioned and mounted at a position where the axes match.
  • the elastic pieces 92 and 93 protrude from the surface on the base end side inside the convex piece 91 on the surface on the base end side of the main body 88.
  • Each of the elastic pieces 92 and 93 has a thin plate shape that can be elastically deformed, and is arranged at a position that is symmetrical with respect to the center line 102 with the front and back surfaces facing each other in parallel.
  • the distance between the positions farthest from the center line 102 in the elastic pieces 92 and 93 is shorter than the inner diameter of the tube 81. Therefore, in a state where the elastic pieces 92 and 93 are not elastically deformed, the elastic pieces 92 and 93 can easily enter and leave the opening at the tip of the tube body 11.
  • the elastic pieces 92 and 93 correspond to the deformed portion.
  • a hole 94 extending toward the distal end side along the center line 102 is formed between the elastic pieces 92, 93 on the base end side of the main body 88, and the hole 94 has a cylindrical shape, and will be described later.
  • 83 lock portions 96 are inserted.
  • the operation member 83 is a substantially quadrangular prism-shaped member that is elongated in the longitudinal direction 101.
  • the operation member 83 has an outer diameter that can be inserted into the internal space of the tube 81, and the length in the longitudinal direction 101 is slightly longer than the length in the longitudinal direction 101 of the tube 81.
  • a lock portion 96 is provided on the distal end side of the operation member 83.
  • the lock portion 96 has a pair of elastic deformation portions 97 and 98 facing each other through a slit 99 penetrating the operation member 83 in a direction orthogonal to the longitudinal direction 101 on the distal end side of the operation member 83.
  • the elastic deformation portions 97 and 98 are curved outward in a state where no external force is applied. When a compressive force along the longitudinal direction 101 is applied to the lock portion 96, the elastic deformation portions 97 and 98 are elastically deformed so as to be greatly bent outward.
  • the elastic deformation portion 97 is formed with a long hole 100 along the longitudinal direction 101 in order to facilitate deformation. A similar long hole 100 is also formed in the elastic deformation portion 98.
  • the cell collection member 82 In the cell collection device 80, for example, in the collection of cervical cells, the cell collection member 82 is attached to the tube 81, the operation member 83 is inserted into the tube 81, and the proximal end side of the tube 81 is closed by the cap 84. Used in the state. In this state, the lock unit 96 is in the locked posture. In the locked posture, the cell collection member 82 is fixed with respect to the tube body 81 in the longitudinal direction 101 and the rotation direction 103. Therefore, when the practitioner holds the proximal end side of the tube body 81 and performs operations such as pushing and pulling and rotating, the force is transmitted to the cell collection member 82, and the cell collection member 82 is integrated with the tube body 81. Move or rotate.
  • the lock portion 96 becomes large.
  • the diameter 95 is reached.
  • the distal end of the lock portion 96 enters the hole 90 of the cell collection member 82, and the elastic deformation portions 97 and 98 are located inside the elastic pieces 92 and 93 of the cell collection member 82.
  • the base end side of the operation member 83 protrudes outward from the base end of the tube body 81.
  • the cap 84 When the cap 84 is screwed into the male thread portion 85 of the tube 81, the proximal end side of the operation member 83 protruding from the proximal end of the tube 81 is pushed into the internal space of the tube 81. As a result, in the large-diameter portion 95 of the tubular body 81, the elastic deformation portions 97 and 98 of the lock portion 96 are pressed against the inner wall of the large-diameter portion 95 via the elastic pieces 92 and 93, and the lock portion 96 is moved in the longitudinal direction 101. Compression force is applied.
  • the elastic deformation portions 97 and 98 are elastically deformed outward, and the elastic pieces 92 and 93 are sandwiched between the inner wall of the large diameter portion 95 while being elastically deformed. That is, the elastic deformation portions 97 and 98 elastically deform the elastic pieces 92 and 93 outward and press them against the inner wall of the large diameter portion 95.
  • the elastic pieces 92 and 93 When the elastic pieces 92 and 93 are sandwiched between the lock portion 31 and the inner wall of the large-diameter portion 95 of the tube body 11, the elastic pieces 92 and 93 move along the longitudinal direction 101 with respect to the tube body 81. , It does not rotate along the rotation direction 103.
  • the posture of the lock portion 96 that elastically deforms the elastic pieces 92 and 93 in this way corresponds to the lock posture.
  • the cap 84 is removed from the tubular body 81 by the practitioner as shown in FIG. As a result, the compressive force applied to the lock portion 96 disappears, and the elastically deformable portions 97 and 98 return to the original state. Then, as the operation member 83 is moved in the direction of pulling out from the proximal end of the tube body 81, the lock portion 96 is pulled out from the large diameter portion 95, and the elastic deformation portions 97 and 98 are elastic pieces of the cell collection member 82. Separate from 92,93. Thus, the posture of the lock portion 96 (the position in the longitudinal direction 101 in this embodiment) where the elastic pieces 92 and 93 are not elastically deformed corresponds to the release posture.
  • the elastic pieces 92 and 93 that have been restored to the original state can easily enter and leave the opening at the tip of the tube body 81. Therefore, the cell collection member 82 attached to the tip of the tube body 81 is easily separated by gravity when, for example, the longitudinal direction 101 of the tube body 81 is along the gravity direction with the cell collection member 82 on the lower side. The tube 81 falls off. The dropped cell collection member 82 is accommodated in a storage container (not shown).
  • the cap 84 is screwed into the male threaded portion 85 of the tube body 81 so that the compression force is applied to the lock portion 96.
  • the male threaded portion 85 and the female threaded portion 86 are retained.
  • the cap 84 may be engaged with the proximal end side of the tubular body 81 without being provided with a movement in the longitudinal direction 101.
  • the lock portion 96 changes its posture from the lock posture to the release posture, but the elastic deformation portions 97 and 98 of the operation member 83 elastically deform from the expanded state to the narrowed state.
  • the lock member 96 may be changed in posture from the lock posture to the release posture by the operation member 83 being pushed into the tube body 81.
  • the elastic deformation portions 97 and 98 are elastically restored, and the elastic deformation portions 97 and 98 of the lock portion 96 are moved. Press against the inner wall of the large diameter portion 95.
  • the elastic pieces 92 and 93 do not move along the longitudinal direction 101 with respect to the tubular body 81 or rotate along the rotation direction 103.
  • the operation member 83 is not attached to the tube body 81 by the spacer 104 or the like being interposed on the proximal end side of the tube body 81 or being engaged with the tube body 81. It is held so as not to be pushed in.
  • the operation member 83 can be pushed into the tube 81 by removing the spacer described above or releasing the engagement.
  • the tip of the lock portion 96 advances to the back of the hole 94 of the cell collection member 82, and the elastic deformation portions 97 and 98 are narrowed. It is elastically deformed.
  • the elastic pieces 92 and 93 are elastically restored and can come out of the large diameter portion 95 of the tube body 81.
  • the cell collection member 82 is removed from the distal end of the tube 81 by pressing the cell collection member 82 with the distal end of the lock portion 96 abutting against the end surface of the hole 94.
  • the cell collection device 110 includes a tube body 111, a cell collection member 112, an operation member 113, and a lock member 114.
  • the cell collection member 112 is detachably attached to the distal end side of the tube body 111.
  • the operation member 113 is inserted into the tube body 111.
  • the lock member 114 is housed in the tube body 111 and engages with the cell collection member 112.
  • the direction in which the elongated tube body 111 extends is referred to as the longitudinal direction 101.
  • a virtual line passing through the center of the tube body 111 along the longitudinal direction 101 is referred to as a center line 102.
  • a direction of rotation about the center line 102 is referred to as a rotation direction 103.
  • the side of the practitioner is referred to as the proximal end side (right side in FIG. 25), and the side to which the cell collection member 112 is attached is referred to as the distal end side (left side in FIG. 25).
  • the distal end of the tube body 111 corresponds to the first end, and the proximal end of the tube body 11 corresponds to the second end.
  • the tube body 111 is a member having a circular tube shape that is elongated in the longitudinal direction 101.
  • the tube body 111 is open at the front end and the rear end, and the internal space is continuous between the front end and the rear end.
  • the tube body 111 is formed, for example, as a synthetic resin molded product.
  • the material and shape of the tube body 111 are not particularly limited, and for example, the outer shape may be a polygonal shape.
  • the outer dimensions of the tube body 111 and the length in the longitudinal direction 101 are optimally set so that the practitioner holds the proximal end side and allows the cell collection member 112 to reach the cervix.
  • a seat portion 119 for positioning the cell collection member 112 is provided on the distal end side of the internal space of the tube body 111.
  • the seat portion 119 has a through hole 120 along the center line 102.
  • the cell collection member 112 has a main body 115 and a brush 116.
  • the main body 115 is, for example, a synthetic resin molded product.
  • the brush 116 is inserted into a hole 117 formed on the front end side of the main body 115 and fixed by an adhesive or the like.
  • the brush 116 has a plurality of synthetic resin fibers fixed to a stainless steel shaft.
  • a known one such as an elastomer molded product may be employed. Therefore, as in the present embodiment, the shaft may extend along the center line 102 of the tube body 111, and the fibers may expand radially from the shaft, or other shapes may be employed. Also good.
  • the brush 116 is omitted.
  • the main body 115 has a substantially conical outer shape.
  • the outer diameter of the base end side of the main body 115 is slightly smaller than the inner diameter of the tube body 111. Therefore, the main body 115 can be inserted into the internal space from the tip of the tube body 111.
  • An engagement portion 118 that protrudes along the center line 102 from the surface is provided on the base end surface of the main body 115.
  • the engaging portion 118 has a substantially cylindrical shape, and a flange-shaped engaging piece 129 having an outer diameter expanding is formed at the protruding end.
  • the engaging portion 118 has an outer dimension that can be inserted into the through hole 120 of the seat portion 119 of the tubular body 111.
  • the engaging portion 118 passes through the through hole 120 of the seat portion 119, and the base end side surface of the main body 115 contacts the seat portion 119. As a result, the main body 115 is positioned and attached to the tip of the tube body 111.
  • the operation member 113 is a member having a circular tube shape elongated in the longitudinal direction 101.
  • the operation member 113 has an outer diameter that can be inserted into the internal space of the tube body 111, and the length in the longitudinal direction 101 is slightly shorter than the length in the longitudinal direction 101 of the tube body 11.
  • the distal end of the operation member 113 is open, and a tapered guide surface 121 whose inner diameter increases is provided on the inner peripheral surface side of the periphery.
  • a flange portion 122 that protrudes outward away from the center line 102 is provided.
  • the outer diameter of the flange portion 122 is larger than the inner diameter of the tube body 111. Therefore, the operation member 113 inserted from the proximal end side of the tube body 111 is restricted from being further inserted by the flange portion 122 coming into contact with the proximal end of the tube body 111.
  • the lock member 114 includes an outer cylinder portion 123 and a pinch portion 124.
  • the outer cylinder portion 123 has a cylindrical shape in which a space for operating the pinch portion 124 is cut out.
  • the outer cylinder parts 123 arranged with a space therebetween are connected by a connecting part 132.
  • the outer diameter of the outer cylinder portion 123 is smaller than the inner diameter of the tube body 111. Further, the outer diameter of the outer cylinder portion 123 is set so as to be able to contact the seat portion 119 of the tube body 111. Therefore, the lock member 114 inserted into the internal space from the proximal end side of the tube body 111 is positioned with respect to the distal end direction by the outer cylinder portion 123 coming into contact with the seat portion 119.
  • the pinch part 124 is connected to the proximal end side of the outer cylinder part 123.
  • the pinch portion 124 can be changed in posture so that the pair of flat plate members 125 and 126 are rotated by elastic deformation of a connection portion between the connecting portion 132 and the outer cylinder portion 123.
  • the pair of flat plate members 125 and 126 are in a posture in which the proximal end side is relatively expanded with respect to the distal end side in a state where no external force is applied.
  • flange portions 127 and 128 are formed, respectively, protruding in opposite directions.
  • the hooks 127 and 128 are fitted into the proximal end side of the main body 115 from the engagement piece 129 of the engagement portion 118 of the cell collection member 112 and can be engaged with the engagement portion 118.
  • a coil spring 131 is disposed between the lock member 114 and the operation member 113 with the longitudinal direction 101 as the compression direction.
  • the coil spring 131 is in contact with the outer cylinder portion 123 of the lock member 114 and the distal end of the operation member 113, and urges the operation member 113 in a direction to exit from the proximal end of the tube body 111.
  • the guide surface 121 of the operation member 113 urged by the coil spring 131 is in a position in contact with or close to the base ends of the flat plate members 125 and 126 of the lock member 114.
  • the flat plate members 125 and 126 do not receive a force sufficient to change the posture from the operation member 113, and are held in a posture in which the proximal end side is relatively expanded with respect to the distal end side.
  • the posture of the lock member 114 at this time corresponds to the lock posture.
  • the cell collection member 112 In the cell collection device 110, for example, in the collection of cervical cells, the cell collection member 112 is mounted on the tube body 111, the operation member 113 is engaged with the locking member 114 and the engagement portion 118 of the cell collection member 112. Used in the locked position. Due to the engagement between the lock member 114 and the engagement portion 118 of the cell collection member 112, the main body 115 is pressed against the seat portion 119, and the cell collection member 112 is moved in the longitudinal direction 101 and the rotation direction 103 with respect to the tube body 111. It is fixed against. Therefore, when the practitioner holds the proximal end side of the tube body 111 and performs operations such as pushing and pulling and rotating, the force is transmitted to the cell collection member 112, and the cell collection member 112 is integrated with the tube body 111. Move or rotate.
  • the lock member 114, the coil spring 130, the coil spring 131, and the operation member 113 are sequentially arranged from the proximal end side of the tube body 111. Inserted. In the state where the flange portions 127 and 128 of the flat plate members 125 and 126 of the lock member 114 are in contact with the engaging portion 118 of the cell collection member 112 inserted through the through hole 120 of the seat portion 119, the biasing force of the coil spring 131 is applied.
  • the guide surface 121 of the operation member 113 slides against the base ends of the flat plate members 125 and 126, and the flat plate members 125 and 126 along the guide surface 121. Is guided in the direction of narrowing the interval. Thereby, the front end side of the flat plate members 125 and 126 is expanded, and the interval between the flange portions 127 and 128 is larger than the outer diameter of the engagement piece 129 of the engagement portion 118.
  • the coil spring 130 In order to resist the biasing force of the coil spring 130, when the operation member 113 is further pushed into the tube body 111 in a state where the cell collection member 112 is fixed to the tube body 111 so as not to come out, the coil spring 130 is compressed and deformed. The lock member 114 moves until it comes into contact with the seat 119. Thereafter, when the pushing of the operating member 113 is stopped, the operating member 113 is moved in a direction of coming out of the tube body 111 by the biasing force of the coil spring 130. Along with this, the guide surface 121 of the operation member 113 also moves to the proximal end side of the tube body 111.
  • the flat plate members 125 and 126 are elastically returned to the posture in which the proximal end side is relatively expanded with respect to the distal end side, and the flange portions 127 and 128 are engaged with the engagement portion 118 of the cell collection member 112.
  • the lock member 114 and the engaging portion 118 engage with each other by entering the base end side of the main body 115 from the piece 129.
  • the cell collection member 112 is held in a state of being attached to the distal end side of the tube body 111 against the urging force of the coil spring 131.
  • the flange portion 122 of the operation member 113 is pushed toward the proximal end side of the tubular body 111 against the biasing force of the coil spring 131 by the practitioner. . Accordingly, the operation member 113 is pushed into the tube body 111, the guide surface 121 of the operation member 113 slides with respect to the base ends of the flat plate members 125 and 126, and the flat plate members 125 and 126 are moved along the guide surface 121. The proximal end is guided in the direction of narrowing the interval.
  • the front end side of the flat plate members 125 and 126 is expanded, and the interval between the flange portions 127 and 128 is larger than the outer diameter of the engagement piece 129 of the engagement portion 118. That is, the engagement between the engagement portion 118 and the lock member 114 is released.
  • the posture of the lock member 114 at this time corresponds to the release posture.
  • the cell collection member 112 is pulled out from the distal end of the tube body 111 by the biasing force of the coil spring 130.
  • the removed cell collection member 112 is accommodated in a storage container (not shown).
  • the cell collection device 150 includes a tube body 151, a cell collection member 152, and an operation member 153.
  • the cell collection member 152 is detachably attached to the distal end side of the tube body 151.
  • the operation member 153 is inserted into the tube body 151.
  • the direction in which the elongated tube body 151 extends is referred to as the longitudinal direction 101.
  • a virtual line passing through the center of the tube body 151 along the longitudinal direction 101 is referred to as a center line 102.
  • a direction of rotation about the center line 102 is referred to as a rotation direction 103.
  • tube 151 the side of the practitioner is referred to as the proximal end side (right side in FIG. 31), and the side to which cell collection member 152 is attached is referred to as the distal end side (left side in FIG. 31).
  • the distal end of the tubular body 151 corresponds to the first end, and the proximal end of the tubular body 151 corresponds to the second end.
  • the tube body 151 is a tubular member whose outer shape is cylindrical in the longitudinal direction 101.
  • the tube body 51 has an opening at the front end and a rear end, and a circular internal space is continuous between the front end and the rear end.
  • the tubular body 151 is formed as a molded product of synthetic resin, for example.
  • the material and shape of the tubular body 151 are not particularly limited.
  • the outer shape may be a prismatic shape.
  • the outer dimensions of the tube body 151 and the length in the longitudinal direction 101 are optimally set so that the practitioner has the proximal end side and allows the cell collection member 152 to reach the cervix.
  • a groove 154 is provided on the surface of the tube body 151 on the tip side.
  • the groove 154 is recessed in the longitudinal direction from the surface on the distal end side of the tube body 151, and has a hexagonal shape along the outer shape of the tube body 151 as viewed from the viewpoint along the center line 102.
  • the convex piece 158 of the cell collection member 152 is inserted in the groove 154. Therefore, the depth along the center line 102 of the groove 154 is approximately the same as the dimension of the convex piece 158 protruding from the main body 155 along the center line 102 in the cell collection member 152.
  • a large-diameter portion 166 in which the diameter of the internal space is increased is provided on the inner surface on the proximal end side of the tube body 151.
  • the large diameter portion 166 extends in the longitudinal direction from the opening on the proximal end side of the tube body 151.
  • a bulging portion 167 is provided on the proximal end side of the tube body 151.
  • Four bulging portions 167 are arranged at intervals in the circumferential direction of the inner surface of the tube body 151.
  • Each bulging portion 167 and the stepped portion 168 at the extending end of the large diameter portion 166 are separated in the longitudinal direction.
  • the flange portion 163 of the operation member 153 is inserted into the large diameter portion 166 and engages with each bulging portion 167.
  • the cell collection member 152 has a main body 155 and a brush 156.
  • the main body 155 is, for example, a synthetic resin molded product.
  • the brush 156 is inserted into a hole 157 formed on the distal end side of the main body 155 and fixed with an adhesive or the like.
  • the brush 156 has a plurality of synthetic resin fibers fixed to a stainless steel shaft.
  • a known one such as an elastomer molded product may be employed. Therefore, as in this embodiment, the shaft may extend along the center line 102 of the tube body 151, and the fibers may spread radially from the shaft, or other shapes may be employed. Also good.
  • the main body 155 has a substantially cylindrical outer shape.
  • a convex piece 158 projecting from the surface of the base end side of the main body 155 is provided.
  • the convex piece 158 protrudes along the center line 102 from the surface on the base end side of the main body 155, and has a hexagonal shape as viewed from the viewpoint along the center line 102.
  • the dimension that the convex piece 158 protrudes from the main body 155 along the center line 102 is approximately the same as the dimension along the center line 102 of the male thread portion 161 of the operation member 153 described later.
  • the thickness of the convex piece 158 is set so that it can be inserted into the groove 154 of the tube body 151. Further, the convex piece 158 has a tapered shape in which the thickness is reduced toward the extending end extending from the main body 155.
  • the convex piece 158 is inserted into the groove 154 of the tube body 151, and the surface 169 on the proximal end side of the main body 155 and the surface on the distal end side of the tube body 151 come into contact with each other. It is positioned and mounted at a position where the axes of the two coincide.
  • the main body 155 does not rotate in the rotation direction 103 with respect to the tube body 151.
  • the groove 154 and the convex piece 158 correspond to the fitting portion.
  • a screw hole 159 extending toward the distal end side along the center line 102 is formed inside the convex piece 158 on the surface 169 on the base end side of the main body 155.
  • the screw hole 159 has a cylindrical shape, and will be described later.
  • the male screw part 161 of the member 153 is screwed.
  • the depth along the center line 102 of the screw hole 159 is approximately the same as the dimension along the center line 102 of the male screw portion 161 of the operation member 153 described later.
  • the operation member 153 includes a rod portion 160, a male screw portion 161, a knob portion 162, and a flange portion 163.
  • the rod portion 160 is a substantially cylindrical member that is elongated in the longitudinal direction 101.
  • the rod portion 160 has an outer diameter that can be inserted into the internal space of the tube body 151, and the length in the longitudinal direction 101 is slightly longer than the length in the longitudinal direction 101 of the tube body 151.
  • a male thread 161 is provided on the distal end side of the operation member 153.
  • the male screw portion 161 is integrally formed on the distal end side of the rod portion 160.
  • the male threaded portion 161 can be threaded into the screw hole 159 of the cell collection member 152.
  • the male screw part 161 corresponds to a lock part and a screwing part.
  • the posture in which the male screw portion 161 is screwed into the screw hole 159 corresponds to the lock posture, and the posture in which the male screw portion 161 is extracted from the screw hole 159 corresponds to the release posture.
  • a knob 162 is provided at the proximal end of the rod 160.
  • the knob 162 has a star-shaped cross section with a minimum outer diameter larger than the outer diameter of the rod section 160 and the inner diameter of the tube body 151.
  • the outer diameter of the rod portion 160 is slightly smaller than the inner diameter of the tube body 151.
  • a flange portion 163 is provided on the proximal end side of the rod portion 160 so as to be separated from the knob portion 162 toward the distal end side.
  • the flange portion 163 protrudes outward from the outer peripheral surface of the rod portion 160 and is continuous along the outer peripheral surface of the rod portion 160.
  • a surface 164 on the distal end side of the flange portion 163 is an outwardly inclined surface away from the center line 102, and a surface 165 on the proximal end side of the flange portion 163 is orthogonal to the center line 102.
  • a space in which the bulging portion 167 of the tube body 151 can be disposed is separated between the surface 165 and the knob portion 162.
  • the outer diameter of the flange portion 163 is smaller than the diameter of the large diameter portion 166 of the tube body 151 and larger than the distance between the tips of the bulging portion 167 and the diameter of the internal space other than the large diameter portion 166 of the tube body 151.
  • the cell collection device 150 is used, for example, in the collection of cervical cells, with the cell collection member 152 mounted on the tube 151 and the male screw portion 161 of the operation member 153 screwed into the screw hole 159.
  • the male screw portion 161 is in the locked posture, the cell collection member 152 is fixed with respect to the tube body 151 in the longitudinal direction 101 and the rotation direction 103. Therefore, when the practitioner holds the proximal end side of the tube body 151 and performs operations such as pushing and pulling and rotating, the force is transmitted to the cell collection member 152, and the cell collection member 152 is integrated with the tube body 151. Move or rotate.
  • the convex piece 158 of the cell collection member 152 and the groove 154 of the tube body 151 are fitted in the state where the cell collection member 152 is attached to the tip of the tube body 151. Accordingly, the cell collection member 152 does not rotate in the rotation direction 103 with respect to the tube body 151. Further, the operation member 153 is inserted from the base end, and the male screw portion 161 of the operation member 53 is screwed into the screw hole 159 of the cell collection member 152. As a result, the cell collection member 152 does not move in the longitudinal direction 101 with respect to the tube body 151.
  • the operation member 153 When the operation member 153 is inserted into the opening of the proximal end of the tube body 151 from the male screw portion 161 side when the cell collection device 150 is assembled, the surface 164 of the flange portion 163 comes into contact with the bulging portion 167.
  • the large-diameter portion 166 is elastically deformed so as to expand its diameter, and the flange portion 163 enters between the stepped portion 168 and the bulging portion 167.
  • the flange portion 163 In this state, the flange portion 163 is in a state of being sandwiched and engaged between the step portion 168 and the bulging portion 167, and relative movement with the tubular body 151 is restricted with respect to the longitudinal direction 101.
  • the operation member 153 In the engaged state, the operation member 153 can rotate relative to the tube body 151 in the rotation direction 103.
  • the operator holds the knob 162 of the operation member 153 and the proximal end side of the tube 151, and the knob 162 is located with respect to the tube 151. Is rotated. As a result, the male screw portion 161 of the operation member 153 is extracted from the screw hole 159 of the cell collection member 152. Since the tube body 151 and the operation member 153 do not move relative to the longitudinal direction 101, the male screw portion 161 of the operation member 153 comes out of the screw hole 159 of the cell collection member 152, and the cell collection member 152 is connected to the tube body 151. The protruding piece 158 comes out of the groove 154 away from the tip of the groove 154.
  • the convex piece 158 Since the dimension along the center line 102 of the convex piece 158 and the dimension along the center line 102 of the male screw part 161 are approximately the same, the convex piece 158, the groove 154, and the like until the male screw part 161 comes out of the screw hole 159.
  • the convex piece 158 comes out of the groove 154 and easily falls off the tubular body 151 by gravity.
  • the dropped cell collection member 152 is accommodated in a storage container (not shown).
  • the cell collection device 210 has a bar 211 and a cell collection member 212.
  • the cell collection member 212 is detachably attached to the distal end side of the bar 211.
  • the direction in which the elongated bar 211 extends is referred to as the longitudinal direction 101.
  • An imaginary line passing through the center of the bar 211 along the longitudinal direction 101 is referred to as a center line 102.
  • a direction of rotation about the center line 102 is referred to as a rotation direction 103.
  • the side of the practitioner is referred to as the proximal end side (right side in FIG. 38), and the side to which the cell collection member 212 is attached is referred to as the distal end side (left side in FIG. 38).
  • the bar 211 is an elongated member in the longitudinal direction 101.
  • the bar 211 has a cylindrical outer shape, for example, as a synthetic resin molded product.
  • the material and shape of the bar 211 are not particularly limited, and may be, for example, a polygonal column shape.
  • a plurality of elongated grooves may be formed in the longitudinal direction 101 in order to reduce the amount of resin.
  • the external dimensions of the bar 211 and the length in the longitudinal direction 101 are optimally set so that the practitioner has the proximal end side and allows the cell collection member 212 to reach the cervix.
  • an engaging portion 220 is provided on the distal end side of the bar 211.
  • the engaging part 220 is for changing the posture of the convex part 221 projecting in the longitudinal direction 101 from the tip end of the bar 211, the claws 222 and 223 projecting outward of the bar 211, and the claws 222 and 223, respectively.
  • pressing portions 224 and 225 are respectively arranged as a pair at positions symmetrical with respect to the center line 102.
  • the claws 222 and 223 and the pressing portions 224 and 225 have the same shape except for the arrangement, the claws 222 and 223 and the pressing portions 224 and 225 are described in detail by taking the claw 222 and the pressing portion 224 as one pair as an example. The configuration is described.
  • the convex portion 221 has a substantially cylindrical outer shape protruding along the longitudinal direction 101 from the tip of the bar 211.
  • the peripheral surface 226 of the convex portion 221 has a tapered shape that tapers toward the protruding end from the bar 211, that is, the tip.
  • the center of the convex portion 221 matches the center line 102 of the bar 211. That is, the convex portion 221 is disposed on the center line 102 of the bar 211.
  • the taper shape of the convex portion 221 is such that the peripheral surface 226 of the convex portion 221 and the peripheral surface 247 of the concave portion 246 come into contact with each other when inserted into the concave portion 246 described later.
  • the claws 222 and 223 protrude from the vicinity of the tip of the bar 211 toward the outside perpendicular to the center line 102.
  • the claw 222 has a mountain shape protruding toward the outside of the bar 211 in the cross section along the center line 102.
  • On the tip side of the claw 222 an inclined surface 227 that is inclined toward the center line 102 toward the tip is formed.
  • a locking surface 228 that is substantially orthogonal to the center line 102 is formed on the base end side of the claw 222.
  • the inclined surface 227 and the locking surface 228 are continuous, and the boundary between the inclined surface 227 and the locking surface 228 is a mountain-shaped ridge line.
  • the distance from the center line 102 of the mountain-shaped ridge line of the claw 222 is approximately the same as the distance from the center line 102 of the outer peripheral surface on the proximal end side of the bar 211.
  • a groove 229 extending along the center line 102 is formed between the claw 222 and the convex portion 221.
  • a groove 230 is formed for the claw 223.
  • the groove 229 opens on the outer surface of the bar 211. That is, the groove 229 passes through the bar 211.
  • a space is formed between the claw 222 and the convex portion 221 by the groove 229.
  • the posture of the claw 222 in which the elastic deformation portion 231 is tilted toward the convex portion 221 is referred to as a release posture.
  • the claw 223 changes its posture from the engagement posture to the release posture.
  • the pressing parts 224 and 225 are provided outside the elastic deformation parts 231 and 232, respectively.
  • the pressing part 224 bulges outside in a state of being exposed on the outer surface of the bar 211 outside the elastic deformation part 231.
  • the pressing portion 224 has a mountain shape in the cross section along the center line 102, and is a groove extending in a direction orthogonal to the longitudinal direction 101 on the inclined surface 233 facing the proximal end side of the bar 211. Are formed at intervals in the longitudinal direction 101.
  • the inclined surface 233 facing the proximal end side makes it easy for the pressing portion 224 to be pushed from the proximal end side of the bar 211, and the fingers of the practitioner are less likely to slide to the distal end side due to the plurality of grooves formed in the inclined surface 233.
  • a plurality of grooves are formed on the inclined surface 234 of the pressing portion 225.
  • the cell collection member 212 has a main body 240 and a brush 241.
  • the main body 240 is, for example, a synthetic resin molded product.
  • the brush 241 is inserted into a hole 242 formed on the front end side of the main body 240 and fixed with an adhesive or the like.
  • the brush 241 has a plurality of synthetic resin fibers fixed to a stainless steel shaft.
  • a known one such as an elastomer molded product can be adopted. Therefore, as in this embodiment, the shaft may extend along the center line 102 of the bar 211, and the fibers may spread radially from the shaft, or other shapes may be employed. Also good.
  • a cylindrical portion 243 is formed on the base end side of the main body 240.
  • the cylindrical portion 243 has an opening 244 on the proximal end side. Through the opening 244 of the cylindrical portion 243, the engaging portion 220 of the bar 211 can be inserted into the internal space of the cylindrical portion 243.
  • the opening 244 is elongated in a direction (vertical direction in FIG. 40) in which the claws 222 and 223 of the engaging portion 220 are arranged.
  • the internal space of the cylindrical portion 243 is set to a size and shape that allows the convex portion 221 and the claws 222 and 223 of the engaging portion 220 to be inserted.
  • a concave portion 246 is formed on the end surface 245 opposite to the opening 244 in the internal space of the cylindrical portion 243.
  • the recess 246 is provided on the center line 102 of the cell collection member 212 and extends toward the distal end side along the center line 102.
  • the concave portion 246 is set to have a shape and size corresponding to the convex portion 221 of the engaging portion 220. That is, the concave portion 246 has a tapered shape with a small diameter toward the distal end side so that the peripheral surface 247 abuts on the peripheral surface 226 of the convex portion 221.
  • a pair of holes 249 and 250 penetrating the peripheral wall 248 in the direction orthogonal to the center line 102 are formed in the peripheral wall 248 of the cylindrical portion 243.
  • the holes 249 and 250 are disposed as a pair at positions symmetrical with respect to the center line 102. Since the holes 249 and 250 have the same shape except for the disposition, the detailed configuration of the holes 249 and 250 will be described in the pair of holes 249.
  • the hole 249 is a rectangular through hole.
  • the shape of the hole 249 is set corresponding to the claw 222 of the engaging portion 220.
  • a claw 222 can be inserted into the hole 249. Therefore, the dimension of the hole 249 is set larger than the outer dimension of the claw 222.
  • the locking surface 228 of the claw 222 can come into contact with the peripheral edge of the hole 249. Thereby, the nail
  • a claw 223 is inserted into the hole 250 and engaged therewith.
  • the cell collection device 210 is used in a state where the cell collection member 212 is attached to the rod 211 in collecting cervical cells.
  • the convex part 221 and the claws 222 and 223 of the engaging part 220 of the bar 211 are inserted into the internal space from the opening 244 of the cylindrical part 243 of the cell collection member 212.
  • the engaging portion 220 is inserted into the elongated opening 244 with the claws 222 and 223 arranged in the elongated direction of the opening 244.
  • the cell collection member 212 is substantially fixed in the rotation direction 103 with respect to the bar 211.
  • the convex portion 221 is inserted into the concave portion 246, and the claws 222 and 223 are engaged with the holes 249 and 250 of the peripheral wall 248 of the cylindrical portion 243. It is fixed with respect to the direction 101 and the rotation direction 103.
  • the convex portion 221 of the engaging portion 220 has the tapered peripheral surface 226 pressed against the peripheral surface 247 of the concave portion 246. Yes. Due to the pressure contact between the peripheral surface 226 and the peripheral surface 247, a force for pushing the bar 211 toward the distal end along the longitudinal direction 101 and a force for rotating the bar 211 in the rotation direction 103 are transmitted to the cell collection member 212. . When these forces are transmitted, it is desirable that the claws 222 and 223 of the engaging portion 220 inserted into the holes 249 and 250 of the peripheral wall 248 of the cylindrical portion 243 are not in contact with the peripheral edges of the holes 249 and 250. Thereby, no load is generated on the claws 222 and 223 in the transmission of these forces.
  • the bar 211 By engaging the claws 222 and 223 with the holes 249 and 250 of the peripheral wall 248, for example, the engaging surface 228 of the claw 222 engages with the peripheral edge of the hole 249, the bar 211 is moved to the proximal side along the longitudinal direction 101. The pulling force is transmitted to the cell collection member 212.
  • the pressing portions 224 and 225 are pressed, so that the claws 222 and 223 in the engaged posture are changed to the released posture. Since the inclined surfaces 233 and 234 of the pressing portions 224 and 225 face the base end side of the bar 211, the pressing portions 224 and 225 are moved from the base end side of the bar 211 without directly touching the cell collection member 212. Can be pressed. Moreover, since the pressing parts 224 and 225 are disposed at symmetrical positions with respect to the center line 102 and the pressing directions are opposite to each other, the pressing parts 224 and 225 are pressed at once so as to sandwich the pressing parts 224 and 225. Is easy.
  • the elastic deformation portions 231 and 232 are elastically deformed so as to approach the convex portion 221.
  • the claws 222 and 223 also move in a direction approaching the convex portion 221 to be in a release posture.
  • the pawls 222 and 223 in the released posture are disengaged from the holes 249 and 250 in the peripheral wall 248 of the cylindrical portion 243.
  • the cell collection member 212 and the bar 211 can be moved relative to each other in the longitudinal direction 101. In the state where the claws 222 and 223 are inserted into the opening 244, the cell collection member 212 does not rotate in the rotation direction 103 with respect to the bar 211.
  • the cell collection member 212 is detached from the rod 211 by being operated so that the longitudinal direction 101 of the rod 211 is along the vertical direction so that the cell collection member 212 is below the rod 211.
  • the dropped cell collection member 212 is accommodated in a storage container (not shown).
  • the convex portion 221 of the engaging portion 220 is inserted into the concave portion 246 of the cylindrical portion 243, and the claws 222 and 223 in the engaging posture are engaged with the holes 249 and 250 of the peripheral wall 248 of the cylindrical portion 243. Accordingly, when collecting cells of the cervix, the cell collection member 212 is not detached from the bar 211, and the cell collection member 212 is easily detached from the bar 211 after collection.
  • the engaging portion 220 is provided on the bar 211, it is not necessary to touch the cell collection member 212 when the pressing portions 224 and 225 are pressed.
  • the protrusions 221 are provided on the bar 211, it is easy to increase the distance between the protrusions 221 and the claws 222 and 223 in the bar 211. Thereby, the movement amount of the claws 222 and 223 from the engagement posture to the release posture can be increased. As a result, the amount of engagement between the claws 222 and 223 and the holes 249 and 250 of the peripheral wall 248 of the cylindrical portion 243 can be increased.
  • the convex portion 221 has a tapered shape in which the peripheral surface 226 is tapered toward the tip, and the peripheral surface 226 is in pressure contact with the peripheral surface 247 of the concave portion 246 in a state where the cell collection member 212 is mounted on the rod 211. Therefore, when the practitioner pushes the bar 211 and rotates the force to the cell collection member 212, these forces are applied to the engagement points between the claws 222 and 223 and the holes 249 and 250. Not.
  • the protruding portion 221 is provided on the bar 211
  • the concave portion 246 is provided on the cell collection member 212
  • the convex portion 221 is inserted into the concave portion 246.
  • FIG. 43 a configuration in which a concave portion 246 is provided in the bar 211 and a convex portion 221 is provided in the cell collection member 212 may be employed.
  • a configuration in which a pair of claws 222 and 223, pressing portions 224 and 225, and holes 249 and 250 are provided is shown.
  • Only one of them may be provided with, for example, the claw 222, the pressing part 224, and the hole 249 only.
  • a space for providing a pair of claws 222, 223, pressing portions 224, 225, and holes 249, 250 is not necessary, so that the outer dimensions of the bar 211 can be reduced or the engaging portion 220 can be made compact.
  • the convex portion 221 and the concave portion 246 may be arranged offset from the center line 102.
  • a coil spring 235 may be provided in the recess 246 of the cell collection member 212 as shown in FIGS. 45 and 46.
  • FIG. 45 in a state where the cell collection member 212 is mounted on the bar 211, the convex part 221 of the bar 211 is inserted into the concave part 246 while compressing and deforming the coil spring 235, and the claws 222 and 223 are By engaging with the holes 249 and 250 of the peripheral wall 248 of the cylindrical portion 243, the cell collection member 212 is fixed with respect to the rod 211 in the longitudinal direction 101 and the rotation direction 103. Further, the cell collection member 212 is held in a state where it is mounted on the bar 211 against the urging force of the coil spring 235.
  • the engaging portion 220 is provided in the bar 211 and the cylindrical portion 243 is provided in the cell collection member 212 is shown, but the cylindrical portion 243 is provided in the bar 211. May be provided, and the cell collection member 212 may be provided with the engaging portion 220.
  • the convex portion 221 has a tapered shape in which the circumferential surface 226 is tapered toward the tip, and the circumferential surface 226 is in a state where the cell collection member 212 is mounted on the rod 211.
  • a configuration in which the peripheral surface 226 of the convex portion 221 and the peripheral surface 247 of the concave portion 246 are not press-contacted may be employed. In such a configuration, the force in the rotation direction 103 is not transmitted by the pressure contact between the convex portion 221 and the concave portion 246.
  • the force in the rotation direction 103 is transmitted from the bar 211 to the cell collection member 212.
  • the convex portion 221 has a polygonal column shape and the concave portion 246 has a polygonal shape into which the polygonal column shape of the convex portion 221 is fitted, the force in the rotation direction 103 is caused by the fitting between the convex portion 221 and the concave portion 246. 211 is transmitted to the cell collection member 212.
  • the convex portion 221 of the engaging portion 220 of the bar 211 has a substantially cylindrical outer shape protruding from the tip of the bar 211 along the longitudinal direction 101.
  • FIG. , 48 the convex portion 221 projects from the tip of the bar 211 along the longitudinal direction 101, and has an outer shape of a column whose cross-sectional shape perpendicular to the center line 102 is a “+ (plus)” shape. It may be.
  • a concave portion 246 formed on the end surface 245 opposite to the opening 244 in the inner space of the cylindrical portion 243 in accordance with the shape of the convex portion 221 is a center line 102 corresponding to the “+”-shaped convex portion 221.
  • the cross-sectional shape orthogonal to the “+” shape is the dent along the center line 102, and the “+” shape outer surface abuts the corresponding outer surface of the “+” shape convex portion 221.
  • the force in the rotational direction 103 from the bar 211 to the cell collection member 212 is easily transmitted by the “+”-shaped convex portion 221 and the concave portion 246 corresponding to each other. Further, the convex portion 221 is difficult to bend with respect to an external force from a direction orthogonal to the center line 102, and the phenomenon that the claws 222 and 223 are detached from the holes 249 and 250 due to the convex portion 221 being bent is less likely to occur.
  • the “+”-shaped convex portion 221 has a center line 102 when viewed along the center line 102 (direction perpendicular to the paper surface of FIG. 49A).
  • the thicknesses of two “-(minus)” shapes orthogonal to each other may be different.
  • the orthogonal “ ⁇ ” shapes have different thicknesses.
  • the convex portion 221 is formed on the end surface 245 of the cylindrical portion 243 in accordance with the shape.
  • the “+”-shaped recess of the recess 246 also has two “ ⁇ (minus)”-shaped thicknesses perpendicular to the center line 102 (dimension d1 along the horizontal direction in FIG. 49B, dimension along the vertical direction). d2) is different.
  • the protrusions 221 and the recesses 246 described above are arranged in such a relationship that the claws 222 and 223 of the bar 211 and the holes 249 and 250 of the peripheral wall 248 of the cylindrical part 243 can be engaged with each other. That is, when the thicker “ ⁇ ” shape (dimension d1) of the “+” shape of the convex portion 221 matches the thicker “ ⁇ ” shape (dimension d1) of the “+” shape of the concave portion 246, The claws 222 and 223 can be engaged with the holes 249 and 250.
  • the relative positional relationship between the bar 211 and the cylindrical portion 243 of the cell collection member 212 rotates 90 degrees with respect to the center line 102, and the positional relationship in which the claws 222 and 223 cannot engage with the holes 249 and 250.
  • the thicker “ ⁇ ” shape (dimension d1) of the “+” shape of the convex portion 221 fits into the thinner “ ⁇ ” shape (dimension d2) of the “+” shape of the concave portion 246.
  • the thickness of the convex portion 221 in the “ ⁇ ” shape is larger than the thickness of the concave portion 246, the cell collection member 212 cannot be attached to the rod 211 in this positional relationship. This prevents the projection 221 from being inserted into the recess 246 in a state where the claws 222 and 223 are not engaged with the holes 249 and 250 when the rod 211 and the cell collection member 212 are assembled. .
  • Each of the cell collection devices 10, 50, 70, 80, 110, 150, and 210 described above may have a cap 300 that covers each of the cell collection members 12, 52, 82, 112, 152, and 212. .
  • the cell collection device 210 according to the modification of the seventh embodiment will be specifically described as an example.
  • the cap 300 has a cylindrical shape that can contain the cell collection member 212, and both ends thereof. The ends 301 and 302 which become are open. Therefore, the inner diameter of the cap 300 is equal to or slightly larger than the maximum outer diameter of the cell collection member 212.
  • the distal end side of the cap 300 that is, the end 301 that does not serve as the insertion port for the cell collection member 212 may be closed, and the inner diameter of the cap 300 is not necessarily constant along the longitudinal direction 101. Also good.
  • the cap 300 is attached to the cell collection device 210 such that the cell collection member 212 is inserted into the end 302 of the cap 300. In this state, the end 302 of the cap 300 comes into contact with the end surfaces 251 and 252 on the tip side of the pressing portions 224 and 225 (the side facing the end 302 of the cap 300).
  • the end surfaces 251 and 252 are flat surfaces that are substantially orthogonal to the center line 102 of the bar 211 and project outward from the outer peripheral surface of the cap 300 attached to the cell collection device 210 on the end 302 side.
  • the dimension in which the end surfaces 251 and 252 protrude from the outer peripheral surface of the cap 300 is larger than the dimension by which the pressing portions 224 and 225 can be pressed toward the center line 102. Therefore, even if the pressing portions 224 and 225 are pressed toward the center line 102, the end surfaces 251 and 252 protrude outward from the outer peripheral surface on the end 302 side of the cap 300.
  • the end 302 of the cap 300 is not inserted from the end surfaces 251 and 252 to the base end side (right side in FIG. 50) of the bar 211, when the cap 300 is attached to the cell collection device 210, the pressing portion 224 is inserted. , 225 are pushed into the internal space of the cap 300 and are not pushed toward the center line 102 side. That is, when the cap 300 is attached to the cell collection device 210, the claws 222 and 223 are not detached from the holes 249 and 250. Thereby, when the cap 300 is removed from the cell collection device 210, the cell collection member 212 together with the cap 300 is not unintentionally detached from the bar 211.
  • the end surfaces 251 and 252 of the pressing portions 224 and 225 are closer to the front end side of the bar 211 (the end surface 302 side of the cap 300) than the inner side with respect to the center line 102. In such an inclination, the end 302 of the cap 300 can be more reliably prevented from going over the end surfaces 251 and 252 and proceeding to the base end side of the bar 211.
  • the end surface 302 of the cap 300 attached to the cell collection device 210 abuts on the convex portions 253 and 254 and does not advance from the end surfaces 251 and 252 of the pressing portions 224 and 225 to the proximal end side of the bar 211.
  • the same effects as described above are exhibited. Note that only one of the convex portions 253 and 254 may be provided on the bar 211.
  • the bar material is arranged closer to the distal end side of the bar material 211 than the press parts 224 and 225 without contacting the end surfaces 251 and 252 of the press parts 224 and 225 with the end surface 302 of the cap 300.
  • An annular flange 255 protruding outward from the outer peripheral surface of 211 may be provided. The flange 255 protrudes outward from the bar 211 from the outer peripheral surface of the cap 300 on the end 302 side.
  • the flange 255 is not necessarily provided continuously around the center line 102 of the bar 211, but may be provided only at a part around the center line 102.
  • the bar material is located closer to the distal end side of the bar material 211 than the press parts 224 and 225 without contacting the end surfaces 251 and 252 of the press parts 224 and 225 with the end surface 302 of the cap 300.
  • a large diameter portion 256 in which the outer diameter of 211 is larger than the outer diameter on the end 302 side of the cap 300 may be provided.
  • the end surface 302 of the cap 300 attached to the cell collection device 210 abuts on the surface on the distal end side of the large diameter portion 256, and the proximal end side of the bar 211 from the end surfaces 251 and 252 of the pressing portions 224 and 225. Therefore, the same effect as described above is achieved.
  • the large-diameter portion 256 is not necessarily provided continuously around the center line 102 of the bar 211, but may be provided as a convex portion only on a part around the center line 102.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
PCT/JP2014/063706 2013-05-24 2014-05-23 細胞採取装置 WO2014189130A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR1020217016281A KR102351823B1 (ko) 2013-05-24 2014-05-23 세포 채취 장치
JP2015518301A JP6365534B2 (ja) 2013-05-24 2014-05-23 細胞採取装置
KR1020157035011A KR102292694B1 (ko) 2013-05-24 2014-05-23 세포 채취 장치

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2013-109670 2013-05-24
JP2013109667 2013-05-24
JP2013109670 2013-05-24
JP2013-109667 2013-05-24

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WO2014189130A1 true WO2014189130A1 (ja) 2014-11-27

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Country Status (3)

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JP (1) JP6365534B2 (ko)
KR (2) KR102351823B1 (ko)
WO (1) WO2014189130A1 (ko)

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CN106264562A (zh) * 2016-08-30 2017-01-04 苏州施莱医疗器械有限公司 缩进型头部按压式一次性采血器
CN107811657A (zh) * 2017-11-23 2018-03-20 北京海普威生物技术有限公司 一种子宫颈细胞采样刷
WO2018162716A1 (en) * 2017-03-10 2018-09-13 Aprovix Ab A self-sampling device for vaginal fluid collection
CN114209365A (zh) * 2021-12-22 2022-03-22 湖南港湾科学仪器有限公司 一种胆道及胰管细胞无痛无创收集器
WO2022195328A1 (en) * 2021-03-18 2022-09-22 Chaffringeon Bernard Marie Breakable swab applicator for use with a sampling cloth and a swab kit
EP3928716A4 (en) * 2019-02-21 2022-10-19 Biodyne Co., Ltd. DEVICE FOR COLLECTING EXFOLIATED CELLS FOR EXAMINATION OF THE UTERUS
CN107811657B (zh) * 2017-11-23 2024-06-04 北京海普威生物技术有限公司 一种子宫颈细胞采样刷

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US20050277846A1 (en) * 2004-06-09 2005-12-15 Chun-Shan Chou Cervical tissue sampling device
JP2008534005A (ja) * 2005-03-28 2008-08-28 メディメックス カンパニー リミテッド 腫瘍スクリーニングシステム、液状細胞診（ｌｂｃ）用コレクションバイアル、頸癌液状細胞診（ｌｂｃ）用ブラシ及び細胞診用支持溶液
EP2263552A1 (en) * 2009-06-17 2010-12-22 Switch bvba Snap-release cell collection device

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106264562A (zh) * 2016-08-30 2017-01-04 苏州施莱医疗器械有限公司 缩进型头部按压式一次性采血器
CN106264562B (zh) * 2016-08-30 2023-12-12 苏州施莱医疗器械有限公司 缩进型头部按压式一次性采血器
WO2018162716A1 (en) * 2017-03-10 2018-09-13 Aprovix Ab A self-sampling device for vaginal fluid collection
CN107811657A (zh) * 2017-11-23 2018-03-20 北京海普威生物技术有限公司 一种子宫颈细胞采样刷
CN107811657B (zh) * 2017-11-23 2024-06-04 北京海普威生物技术有限公司 一种子宫颈细胞采样刷
EP3928716A4 (en) * 2019-02-21 2022-10-19 Biodyne Co., Ltd. DEVICE FOR COLLECTING EXFOLIATED CELLS FOR EXAMINATION OF THE UTERUS
WO2022195328A1 (en) * 2021-03-18 2022-09-22 Chaffringeon Bernard Marie Breakable swab applicator for use with a sampling cloth and a swab kit
CN114209365A (zh) * 2021-12-22 2022-03-22 湖南港湾科学仪器有限公司 一种胆道及胰管细胞无痛无创收集器

Also Published As

Publication number Publication date
KR102292694B1 (ko) 2021-08-23
JP6365534B2 (ja) 2018-08-01
KR20210066943A (ko) 2021-06-07
KR102351823B1 (ko) 2022-01-17
KR20160012157A (ko) 2016-02-02
JPWO2014189130A1 (ja) 2017-02-23

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