WO2014157007A1 - Préparation cosmétique pour la peau - Google Patents

Préparation cosmétique pour la peau Download PDF

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Publication number
WO2014157007A1
WO2014157007A1 PCT/JP2014/057894 JP2014057894W WO2014157007A1 WO 2014157007 A1 WO2014157007 A1 WO 2014157007A1 JP 2014057894 W JP2014057894 W JP 2014057894W WO 2014157007 A1 WO2014157007 A1 WO 2014157007A1
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Prior art keywords
mass
extract
skin
component
application
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PCT/JP2014/057894
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English (en)
Japanese (ja)
Inventor
香織 谷口
尾林　裕子
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ライオン株式会社
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Priority to JP2015508438A priority Critical patent/JP6271517B2/ja
Publication of WO2014157007A1 publication Critical patent/WO2014157007A1/fr
Priority to PH12015502172A priority patent/PH12015502172A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin

Definitions

  • the present invention relates to a skin cosmetic.
  • the present invention has no foaming and uneven color at the time of application, in addition to no stickiness at the time of application and after application, can prevent discoloration of the skin cosmetics, and changes within a range in which the skin color does not feel strange immediately after application.
  • An object of the present invention is to provide a skin cosmetic that has both the effect and the sustainability thereof and the long-term whitening effect.
  • the skin cosmetic of the present invention as a means for solving the above-mentioned problems is (A) 0.5 mass% to 15 mass% of at least one selected from cetyl alcohol, cetostearyl alcohol and stearyl alcohol, (B) 0.5 mass% to 5 mass% of at least one of stearic acid and potassium stearate, (C) 0.5% by mass to 5% by mass of at least one of mica coated with titanium oxide and mica coated with titanium oxide containing tin oxide, (D) 0.1% by mass to 10% by mass of a water-swellable clay mineral, and (E) Alpinia katsudai seed extract.
  • the present invention it is possible to solve the above-described problems and achieve the above-mentioned object, there is no foaming and color unevenness at the time of application, and there is no stickiness at the time of application and after application. Discoloration can be prevented, and a skin cosmetic that combines the effect of changing the skin color within a range that does not feel uncomfortable immediately after application and the sustainability thereof, and the long-term whitening effect can be provided.
  • the skin cosmetic of the present invention is coated with (A) at least one selected from cetyl alcohol, cetostearyl alcohol and stearyl alcohol, (B) at least one of stearic acid and potassium stearate, and (C) coated with titanium oxide. At least one of mica coated with titanium oxide containing mica and tin oxide, (D) water-swellable clay mineral, and (E) alpinia katsudai seed extract, (F) mixed extract, It contains other components as necessary.
  • the skin cosmetic of the present invention is emulsified using (A) at least one selected from cetyl alcohol, cetostearyl alcohol, and stearyl alcohol, and (B) at least one of stearic acid and potassium stearate.
  • these components act synergistically, There is no foaming or uneven color at the time, in addition to the non-stickiness at the time of application and after application, the skin cosmetics can be prevented from discoloring, and the effect of changing the skin color within the range that does not feel strange immediately after application
  • Cetyl alcohol, cetostearyl alcohol, stearyl alcohol As the component (A), at least one selected from cetyl alcohol, cetostearyl alcohol and stearyl alcohol is used.
  • the cetyl alcohol is a higher saturated aliphatic alcohol having 16 carbon atoms and is represented as CH 3 (CH 2 ) 15 OH. Also called cetanol or palmityl alcohol.
  • the IUPAC system name is 1-hexadecanol.
  • the stearyl alcohol is a higher saturated aliphatic alcohol having 18 carbon atoms and is represented as CH 3 (CH 2 ) 17 OH.
  • the cetostearyl alcohol is a mixture of cetyl alcohol and stearyl alcohol, and is a mixture of a higher saturated aliphatic alcohol having 16 carbon atoms and a higher saturated aliphatic alcohol having 18 carbon atoms.
  • the content of at least one selected from cetyl alcohol, cetostearyl alcohol, and stearyl alcohol as the component (A) is non-sticky after application, no color unevenness, and the total amount of the skin cosmetics, and From the standpoint of sustaining the effect of changing the skin color within a range that does not give a sense of incongruity, the content is 0.5% by mass to 15% by mass, and preferably 2% by mass to 10% by mass. If the content is less than 0.5% by mass, stickiness after application may occur, or the effect of changing the skin color within a range that does not give an uncomfortable feeling may not be sufficiently maintained. May cause unevenness.
  • ⁇ (B) stearic acid, potassium stearate As the component (B), at least one of stearic acid and potassium stearate is used.
  • the stearic acid is a saturated higher fatty acid and is represented by the molecular formula C 17 H 35 COOH.
  • the IUPAC tissue name is octadecanoic acid.
  • the potassium stearate is the potassium salt of stearic acid.
  • the content of at least one of stearic acid and potassium stearate as the component (B) varies within a range in which foaming is suppressed, no stickiness after application, no stickiness after application, and skin color does not feel strange. From the standpoint of the durability of the effect and non-uniformity of the color, it is 0.5% by mass to 5% by mass and preferably 1.5% by mass to 4.5% by mass with respect to the total amount of the skin cosmetic. If the content is less than 0.5% by mass, the stickiness is felt after coating, the sticking suppression effect over time after coating is not sufficiently obtained, or the effect of changing the skin color within a range in which the skin color does not feel strange does not last. In some cases, if it exceeds 5% by mass, foaming may occur during application or color unevenness may occur.
  • the mica coated with the titanium oxide is not particularly limited, and a commercially available product can be used.
  • Examples of the commercially available product include Timiron Super Gold (manufactured by Merck), Timiron Super Blue (manufactured by Merck), Timiron Super Red (Merck), Timiron Super Green (Merck), Timiron Super Sheen MP1001 (Merck), Timiron Super Sheen MP1005 (Merck), and so on. These may be used individually by 1 type and may use 2 or more types together.
  • the mica coated with the titanium oxide containing tin oxide is not particularly limited, and a commercially available product can be used.
  • a commercially available product examples include Ronafair Balance Gold (manufactured by Merck & Co., Inc.), Ronafair Balance Blue ( Merck), Ronafair Balance Red (Merck), and the like. These may be used individually by 1 type and may use 2 or more types together.
  • the content of at least one of the mica coated with titanium oxide of the component (C) and the mica coated with titanium oxide containing tin oxide is an effect of changing the skin color within a range in which the skin color does not feel strange immediately after application, and From the point of non-uniformity of color, it is 0.5% by mass to 5% by mass and preferably 1% by mass to 4.5% by mass with respect to the total amount of the skin cosmetic. If the content is less than 0.5% by mass, the effect of changing the skin color immediately after application within a range in which the skin color does not feel uncomfortable may not be sufficient. If the content exceeds 5% by mass, the range in which the skin color does not feel uncomfortable immediately after application. The effect of changing the color may be insufficient or color unevenness may occur.
  • the water-swellable clay mineral of component (D) is not particularly limited and may be appropriately selected depending on the intended purpose.
  • montmorillonite and hectorite are preferable from the viewpoint of non-stickiness with time after coating, and montmorillonite having a swelling power of 50 mL / 2 g or more is particularly preferable.
  • the swelling power is determined according to the test method for the swelling power of bentonite according to the 15th revision Japanese Pharmacopoeia.
  • the test method for the swelling power of bentonite is specifically as follows. -Test method for the swelling power of bentonite (15th revision Japanese Pharmacopoeia)- Take 2.0 g of measurement sample (bentonite) and add to a 100 mL graduated cylinder containing 100 mL of water in 10 portions. However, after the previously added measurement sample is almost deposited, the next measurement sample is added. When this is left for 24 hours, the apparent volume of the container lump is above the 20 mL scale. That is, in the test method, the swelling power of the montmorillonite can be obtained by the same method as the test method except that the measurement sample is changed from bentonite to montmorillonite.
  • the water-swellable clay mineral (D) may be a natural product or a synthetic product. Commercial products can also be used. Examples of commercially available products of the component (D) include trade name Kunipia G (swelling power 50 mL / 2 g or more, manufactured by Kunimine Industries Co., Ltd.), trade name Kunipia F (swelling power 45 mL / 2 g or more, manufactured by Kunimine Industries Co., Ltd.).
  • Montmorillonite such as trade name Bengel FW (swelling force 35 mL / 2 g, manufactured by HOJUN Co., Ltd.); saponite such as Smecton SA (produced by Kunimine Kogyo Co., Ltd.); Examples include hectorite such as light (manufactured by Kunimine Kogyo Co., Ltd.); steven site such as trade name Ionite T (manufactured by Mizusawa Chemical Co., Ltd.) Among the montmorillonites, when comparing Kunipia G and Kunipia F, Kunipia G having a swelling power of 50 mL / 2 g or more is more preferable. These may be used alone or in combination of two or more.
  • the content of the water-swellable clay mineral of the component (D) is based on the non-stickiness with time after application and the sustainability of the effect of changing the skin color within a range in which the skin color does not feel strange,
  • the content is 0.1% by mass to 10% by mass, and more preferably 0.2% by mass to 5% by mass. If the content is less than 0.1% by mass, the effect of changing the skin color within a range that does not cause a sense of incongruity may not be sufficient, and if it exceeds 10% by mass, it will feel sticky over time after application. There is.
  • the (E) component Alpinia katsudai seed extract is a seed of Alpinia katsusumai Hayata extracted as it is or after pulverization with a solvent.
  • the solvent for obtaining the Alpinia katsudai seed extract is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, and isobutanol.
  • Lower alcohol or hydrous lower alcohol propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1,3-pentane
  • Polyhydric alcohol or hydrous polyhydric alcohol such as diol, 1,4-pentanediol, 1,3,5-pentanetriol, glycerin, polyethylene glycol; acetone, ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether, diol
  • organic solvents such as ethanol, acetonitrile, xylene, benzene, chloroform, carbon tetrachloride, phenol, toluene, etc .
  • acids eg, hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, etc. adjusted to an appropriate degree
  • the above-mentioned Alpinia katsudai seed extract can be further subjected to a refining operation after solvent extraction.
  • the purification operation include decomposition by adding an acid (eg, hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, organic acid, etc.) or alkali (eg, sodium hydroxide, calcium hydroxide, ammonia, etc.), fermentation or metabolism by a microorganism.
  • an acid eg, hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, organic acid, etc.
  • alkali eg, sodium hydroxide, calcium hydroxide, ammonia, etc.
  • the component (E) Commercially available products of the component (E) include, for example, the trade name Alpinia White (0.2% by mass as the pure extract of Alpinia katsudai seed extract, 69.9% by mass of 1,3-butylene glycol, and 29. 9% by mass, manufactured by Ichimaru Falcos Co., Ltd.).
  • the content of the component (E) Alpinia katsudai seed extract is not particularly limited and may be appropriately selected depending on the intended purpose. From the viewpoint of long-term whitening effect and no discoloration of the cream, the content (E ′) is preferably 0.0002% by mass to 0.02% by mass, more preferably 0.001% by mass to 0.01% by mass. .
  • a commercial item can be used, for example, brand name Plantage EX (0.5 mass% as a pure extract of a licorice root extract, an extract of Kawamomogi extract) 0.047% by mass as the pure content, 0.035% by mass as the pure extract of the Magwa root bark extract, 0.063% by mass as the pure extract of the jujube fruit extract, and 0.045% by mass as the pure extract of the Ogon extract 1,3-butylene glycol 79.405% by mass, and water 19.905% by mass, manufactured by Maruzen Pharmaceutical Co., Ltd.).
  • Plantage EX 0.5 mass% as a pure extract of a licorice root extract, an extract of Kawamomogi extract
  • the content of the component (F) is not particularly limited and may be appropriately selected depending on the intended purpose.
  • a pure extract (F ′) of a mixed extract consisting of an extract and an argon extract 0.00069% by mass to 0.069% by mass is preferable. 0.00345% by mass to 0.0345% by mass is more preferable.
  • the extraction solvent for obtaining each extract used in the present invention is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol and the like.
  • Lower alcohol or water-containing lower alcohol propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1,3- Polyhydric alcohols or hydrous polyhydric alcohols such as pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, glycerin, polyethylene glycol; acetone, ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, A Various organic solvents such as tonitrile, xylene, benzene, chloroform, carbon tetrachloride, phenol, toluene, etc .; acids (eg, hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, etc.) adjusted to appropriate standards
  • Each extract used in the present invention can be further subjected to a refining operation after solvent extraction.
  • the purification operation include decomposition by adding an acid (eg, hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, organic acid, etc.) or alkali (eg, sodium hydroxide, calcium hydroxide, ammonia, etc.), fermentation or metabolism by a microorganism.
  • an acid eg, hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, organic acid, etc.
  • alkali eg, sodium hydroxide, calcium hydroxide, ammonia, etc.
  • the skin cosmetic of the present invention can contain other components as necessary within a range not impairing the effects of the present invention.
  • the other components are not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include nonionic surfactants, silicone oils, ester oils and other oils, silicone powders, polymer compounds, moisturizing agents. Agents, inclusion compounds, vitamins, UV absorbers, UV scattering agents, amino acids, anti-inflammatory agents, cooling agents, antioxidants, colorants, fragrances, preservatives, solvents (eg, ethanol, etc.), fatty acids , Water (for example, purified water, ion-exchanged water, etc.), pH adjuster, and the like.
  • the content of the other components is not particularly limited and can be appropriately selected according to the purpose.
  • the purified water of the other components, the humectant of the other components, methyl paraoxybenzoate, and potassium hydroxide were weighed in a vessel of a vacuum emulsification kettle.
  • the polymer compound of the said other component swollen with purified water was added there, and it heated at 70 degreeC in the pressure reduction state.
  • the component (A), the stearic acid of the component (B), the component (C), the propyl paraoxybenzoate, the titanium oxide, the nonporous spherical silicone powder, the oil component as the other components And the nonionic surfactant were dissolved by heating to 70 ° C.
  • a skin cosmetic can be produced by further cooling in minutes.
  • the pH is measured with a pH meter (for example, HM-30G, manufactured by TOA-DKK Co., Ltd.) at 25 ° C., and can be adjusted to pH 7.0 by adding citric acid.
  • the purified water of the other components, the humectant of the other components, and methyl paraoxybenzoate and potassium hydroxide were weighed in a vacuum emulsification vessel vessel.
  • the polymer compound of the said other component swollen with purified water was added there, and it heated at 70 degreeC in the pressure reduction state.
  • the oil and nonionic surfactant were dissolved by heating to 70 ° C.
  • a skin cosmetic can be produced by further cooling in minutes.
  • the pH is measured with a pH meter (for example, HM-30G, manufactured by TOA-DKK Co., Ltd.) at 25 ° C., and can be adjusted to pH 7.0 by adding citric acid.
  • the dosage form of the skin cosmetic of the present invention is not particularly limited, and can be appropriately selected according to the purpose.
  • it can be selected as a liquid, cream, lotion, foam, gel, powder, Examples include emulsions and solids.
  • the skin cosmetics of the present invention can be used for, for example, day creams (day creams, day creams), makeup bases, powder foundations, cream foundations, liquid foundations, and the like.
  • Examples 1 to 47 and Comparative Examples 1 to 24 The skin cosmetics (day creams) of Examples 1 to 47 and Comparative Examples 1 to 24 having the compositions and contents shown in the following table are classified according to whether stearic acid or potassium stearate is used as the component (B). It was prepared as follows.
  • component (B) ⁇ When stearic acid is used as component (B)> Purified water, a humectant (1,3-butylene glycol, glycerin), methyl paraoxybenzoate, and potassium hydroxide were weighed in a vacuum emulsification vessel vessel according to the following table. A polymer compound (carboxyvinyl polymer) swollen with purified water was added thereto and heated to 70 ° C. under reduced pressure.
  • a humectant 1,3-butylene glycol, glycerin
  • methyl paraoxybenzoate methyl paraoxybenzoate
  • potassium hydroxide potassium hydroxide
  • component (A) or component (A ′), stearic acid or component (B ′) of component (B), component (C), propyl paraoxybenzoate, titanium oxide, nonporous spherical silicone The powder, other oil (cyclopentasiloxane), and nonionic surfactant (sorbitan monostearate, glyceryl tri (caprylic / capric)) were heated to 70 ° C. and dissolved. After dissolution, the dissolved oil and the like were added to the vessel while stirring the paddle, and then cooled to 35 ° C. at 1 ° C./min under reduced pressure.
  • (A) component, (B) component potassium stearate, (C) component, propyl paraoxybenzoate, titanium oxide, nonporous spherical silicone powder, other oils (cyclopentasiloxane), And a nonionic surfactant (sorbitan monostearate, tri (caprylic acid / capric acid) glyceryl) were dissolved by heating to 70 ° C. After dissolution, the dissolved oil and the like were added to the vessel while stirring the paddle, and then cooled to 35 ° C. at 1 ° C./min under reduced pressure. After cooling, add (D) component, (E) component, (F) component and the remaining common components as necessary, and further cool to 25 ° C. at 1 ° C./min. Cosmetics) were manufactured. The pH was measured with a pH meter (manufactured by TOA-DKK, HM-30G) at 25 ° C., and adjusted to pH 7.0 by adding citric acid.
  • X Five or less persons judged that it was favorable.
  • ⁇ E [ ⁇ (L value before application) ⁇ (L value after application) ⁇ 2 + ⁇ (a value before application) ⁇ (a value after application) ⁇ 2 + ⁇ (b value before application) ⁇ (B value after application) ⁇ 2 ] 1/2
  • the average value of ⁇ E is preferably 1.5 or more and less than 9.0, and preferably 3.0 or more and 6. Less than 0 is more preferable. If the average value of ⁇ E is less than 1.5, the change in color may not be known, and if it is 9.0 or more, the color may change too much and feel uncomfortable.
  • ⁇ Evaluation criteria Average value of ⁇ E is 0.0 or more and less than 1.5 ⁇ : Average value of ⁇ E is 1.5 or more and less than 3.0 ⁇ : Average value of ⁇ E is 3.0 or more and less than 6.0 ⁇ : Average of ⁇ E The value is 6.0 or more and less than 9.0 ⁇ : The average value of ⁇ E is 9.0 or more and less than 12.0 ⁇ : The average value of ⁇ E is 12.0 or more
  • ⁇ E ′ [ ⁇ (L value after 5 minutes after application) ⁇ (L value after application and normal life for 4 hours) ⁇ 2 + ⁇ (a value after 5 minutes after application) -(A value after applying and living a normal life for 4 hours) ⁇ 2 + ⁇ (b value after applying and 5 minutes after application)-(after applying and living a normal life for 4 hours) b value) ⁇ 2 ] 1/2
  • the average value of ⁇ E ′ is preferably 0.0 or more and less than 2.0. 0.0 or more and less than 1.0 is more preferable.
  • ⁇ Long-term whitening effect> L-value measurement using a melanin-containing three-dimensional skin model in which human normal skin cells are layered with a simple spectral color difference meter (NF333, manufactured by Nippon Denshoku Industries Co., Ltd.) The measurement was performed with a human Lab value measurement using a spectral color difference meter (NF333, manufactured by Nippon Denshoku Industries Co., Ltd.).
  • medium change every day serum-free medium, medium containing growth factors such as hEGF, hydrocortisone, gentamicin amphotericin B, ⁇ -MSH, and ⁇ -FGF, trade names EPI-100LLM, MatTek
  • medium change every day serum-free medium, medium containing growth factors such as hEGF, hydrocortisone, gentamicin amphotericin B, ⁇ -MSH, and ⁇ -FGF, trade names EPI-100LLM, MatTek
  • PBS phosphate buffered saline
  • a melanin-containing three-dimensional skin model (trade name MEL-312-A, manufactured by MatTek, melanin-containing three-dimensional skin, Asian donor) is incubated at 37 ° C. for 15 hours, and then 100 ⁇ g of PBS is applied to the skin in each cup.
  • Samples are replaced every two days, medium is replaced every day (serum-free medium, medium containing growth factors such as hEGF, hydrocortisone, gentamicin amphotericin B, ⁇ -MSH, and ⁇ -FGF) (Trade name EPI-100LLM, manufactured by MatTek) and cultured at 37 ° C. for 15 days.
  • EPI-100LLM Trade name EPI-100LLM, manufactured by MatTek
  • the skin was fixed using 10% by mass formalin dissolved in PBS (phosphate buffered saline), the L value was measured, and the ⁇ L value was calculated based on the following formula.
  • ⁇ L (L value of cells coated with each sample ⁇ L value of cells coated with PBS used as a negative control) From the obtained average value of ⁇ L, long-term whitening effect was evaluated according to the following evaluation criteria.
  • the average value of ⁇ L is preferably 20 or more, and more preferably 30 or more. If the average value of ⁇ L is less than 20, the long-term whitening effect may not be sufficient.
  • ⁇ E ′′ [ ⁇ (L value before application) ⁇ (L value after one month) ⁇ 2 + ⁇ (a value before application) ⁇ (a value after one month) ⁇ 2 + ⁇ (b before application) Value) ⁇ (b value after one month) ⁇ 2 ] 1/2 From the obtained average value of ⁇ E ′′, long-term whitening effect was evaluated according to the following evaluation criteria.
  • the average value of ⁇ E ′′ is preferably 1.0 or more, and more preferably 2.0 or more.
  • the average value of ⁇ E ′′ is 2.0 or more ⁇ : The average value of ⁇ E ′′ is 1.0 or more and less than 2.0 ⁇ : The average value of ⁇ E ′′ is 0.5 or more and less than 1.0 ⁇ : The average of ⁇ E ′′ Value less than 0.5
  • the skin cosmetic of the present invention can be suitably used for, for example, day cream (daytime cream, daytime cream), makeup base, powder foundation, cream foundation, liquid foundation and the like.
  • Examples of the aspect of the present invention include the following. ⁇ 1> (A) 0.5 mass% to 15 mass% of at least one selected from cetyl alcohol, cetostearyl alcohol and stearyl alcohol, (B) 0.5 mass% to 5 mass% of at least one of stearic acid and potassium stearate, (C) 0.5% by mass to 5% by mass of at least one of mica coated with titanium oxide and mica coated with titanium oxide containing tin oxide, (D) 0.1% by mass to 10% by mass of a water-swellable clay mineral, and (E) Alpinia katsudai seed extract, It is a skin cosmetic characterized by containing.
  • the skin cosmetic according to ⁇ 1> further comprising (F) a mixed extract composed of licorice root extract, Kawara mugwort extract, mugwort bark extract, jujube fruit extract, and urgonum extract.
  • a mixed extract composed of licorice root extract, Kawara mugwort extract, mugwort bark extract, jujube fruit extract, and urgonum extract.
  • the content of the component (E) alpinia katsudai seed extract is 0.001% by mass to 0.01% by mass in terms of pure extract, according to any one of ⁇ 1> to ⁇ 2> above It is a skin cosmetic.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
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  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne une préparation cosmétique pour la peau qui contient (A) de 0,5 à 15 % en masse d'au moins un alcool sélectionné parmi l'alcool cétylique, l'alcool cétostéarylique et l'alcool stéarylique, (B) de 0,5 à 5 % en masse d'acide stéarylique et/ou de stéarate de potassium, (C) de 0,5 à 5 % en masse de mica revêtu d'oxyde de titane et/ou de mica revêtu d'oxyde de titane contenant de l'oxyde d'étain, (D) de 0,1 à 10 % en masse d'un minéral d'argile gonflant dans l'eau et (E) d'un extrait de graines d'alpinia katsumadai.
PCT/JP2014/057894 2013-03-29 2014-03-20 Préparation cosmétique pour la peau WO2014157007A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2015508438A JP6271517B2 (ja) 2013-03-29 2014-03-20 皮膚化粧料
PH12015502172A PH12015502172A1 (en) 2013-03-29 2015-09-16 Skin cosmetic

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013-073036 2013-03-29
JP2013073036 2013-03-29

Publications (1)

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WO2014157007A1 true WO2014157007A1 (fr) 2014-10-02

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PCT/JP2014/057894 WO2014157007A1 (fr) 2013-03-29 2014-03-20 Préparation cosmétique pour la peau

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JP (1) JP6271517B2 (fr)
MY (1) MY177862A (fr)
PH (1) PH12015502172A1 (fr)
WO (1) WO2014157007A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106966913A (zh) * 2017-04-06 2017-07-21 青岛科技大学 一种改进的甲基丙烯酸二烷氨基乙酯的制备方法
JP2018172292A (ja) * 2017-03-31 2018-11-08 株式会社コーセー 化粧料又は皮膚外用剤

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001335499A (ja) * 2000-05-29 2001-12-04 Ichimaru Pharcos Co Ltd 化粧料組成物
JP2002179521A (ja) * 2000-12-13 2002-06-26 Ichimaru Pharcos Co Ltd 植物又は動物抽出物含有化粧料組成物
JP2006290749A (ja) * 2005-04-06 2006-10-26 Ichimaru Pharcos Co Ltd メラニン生成抑制剤
JP2007204379A (ja) * 2006-01-31 2007-08-16 Ichimaru Pharcos Co Ltd ｍＴＯＲを活性化する製剤及びｍＴＯＲを活性化する方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4970720B2 (ja) * 2003-12-15 2012-07-11 株式会社コーセー 水中油型メーキャップ化粧料
JP2005232088A (ja) * 2004-02-19 2005-09-02 Kose Corp 水中油型化粧料
JP2008050271A (ja) * 2006-08-22 2008-03-06 Shiseido Co Ltd メーキャップ化粧料
JP2009242269A (ja) * 2008-03-31 2009-10-22 Kose Corp 水中油型乳化化粧料

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001335499A (ja) * 2000-05-29 2001-12-04 Ichimaru Pharcos Co Ltd 化粧料組成物
JP2002179521A (ja) * 2000-12-13 2002-06-26 Ichimaru Pharcos Co Ltd 植物又は動物抽出物含有化粧料組成物
JP2006290749A (ja) * 2005-04-06 2006-10-26 Ichimaru Pharcos Co Ltd メラニン生成抑制剤
JP2007204379A (ja) * 2006-01-31 2007-08-16 Ichimaru Pharcos Co Ltd ｍＴＯＲを活性化する製剤及びｍＴＯＲを活性化する方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018172292A (ja) * 2017-03-31 2018-11-08 株式会社コーセー 化粧料又は皮膚外用剤
CN106966913A (zh) * 2017-04-06 2017-07-21 青岛科技大学 一种改进的甲基丙烯酸二烷氨基乙酯的制备方法

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JP6271517B2 (ja) 2018-01-31
MY177862A (en) 2020-09-23
PH12015502172A1 (en) 2016-01-25
JPWO2014157007A1 (ja) 2017-02-16

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