WO2014126350A1 - Composition de blanchiment dentaire à plusieurs constituants et procédé de blanchiment dentaire - Google Patents

Composition de blanchiment dentaire à plusieurs constituants et procédé de blanchiment dentaire Download PDF

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Publication number
WO2014126350A1
WO2014126350A1 PCT/KR2014/000936 KR2014000936W WO2014126350A1 WO 2014126350 A1 WO2014126350 A1 WO 2014126350A1 KR 2014000936 W KR2014000936 W KR 2014000936W WO 2014126350 A1 WO2014126350 A1 WO 2014126350A1
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WIPO (PCT)
Prior art keywords
whitening
composition
weight
parts
gel composition
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PCT/KR2014/000936
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English (en)
Korean (ko)
Inventor
신승화
정용일
최다미
김민경
송주동
엄태관
최규옥
Original Assignee
오스템임플란트 주식회사
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Publication of WO2014126350A1 publication Critical patent/WO2014126350A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/38—Percompounds, e.g. peracids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22—Peroxides; Oxygen; Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits
    • A61K2800/882—Mixing prior to application

Definitions

  • a tooth whitening composition and a tooth whitening method are disclosed. More specifically, a multipart tooth whitening composition and a tooth whitening method comprising a whitening gel composition and an activating liquid composition are disclosed.
  • tooth aesthetics are affected by the arrangement, size, color, texture and light transmittance of the tooth. Among these, tooth color is the most sensitive and important factor. It can also cause psychological problems.
  • Tooth discoloration can be classified into endogenous discoloration and exogenous discoloration.
  • Endogenous discoloration includes genetic discoloration and discoloration due to drugs or trauma, and exogenous discoloration includes discoloration due to chemical coloring and aging.
  • Teeth whitening refers to a treatment process that restores the enamel colored or discolored due to the pigment to the original color by using the pharmacological action of the whitening component.
  • the main material showing tooth whitening efficacy is hydrogen peroxide (H 2 O 2 ), which is an important component that removes organic substances attached to teeth by oxidation and bleaches discolored areas.
  • Teeth whitening is divided into dental bleaching, which is performed by a dentist at a high concentration of whitening agents (for example, hydrogen peroxide), and home bleaching, which is carried out using low concentrations of whitening agents at home.
  • whitening agents for example, hydrogen peroxide
  • home bleaching which is carried out using low concentrations of whitening agents at home.
  • the expert tooth whitening has a merit that a large effect can be obtained in a short time, but there is a safety problem that can cause gum damage or ache phenomenon inadvertently during the procedure.
  • the self-whitening is safe, but the disadvantage is that it takes a considerable time to see the whitening effect.
  • One embodiment of the present invention provides a multipart tooth whitening composition comprising a whitening gel composition and an activating liquid composition.
  • Another embodiment of the present invention provides a tooth whitening method using the multipart tooth whitening composition.
  • the whitening gel composition comprises a dental whitening agent, a binder and a first solvent,
  • the activating liquid composition provides a multipart tooth whitening composition comprising a metal component and a second solvent for promoting decomposition of the dental whitening agent.
  • the dental whitening agent may include peroxide, hypochlorite, percarbonate, peroxide or a combination thereof.
  • the binder may include a polymer.
  • the polymer may have a weight average molecular weight of 500,000 ⁇ 4,000,000.
  • the first solvent may include water, ethanol or a combination thereof.
  • the whitening gel composition may include 100 parts by weight of the dental whitening agent, 30 to 1,700 parts by weight of the binder and 300 to 3,200 parts by weight of the first solvent.
  • the metal component of the activating liquid composition may be derived from a metal salt.
  • the metal salt may include iron salt, calcium salt, magnesium salt, copper salt or a combination thereof.
  • the activation liquid composition may further include a chelating agent.
  • the activation liquid composition may have a metal ion concentration of 0.05 to 1 mM.
  • the content of the activating liquid composition may be 5 to 100 parts by weight based on 100 parts by weight of the whitening gel composition.
  • the multi-part tooth whitening composition may further include 50 to 150 parts by weight of the activated gel composition based on 100 parts by weight of the whitening gel composition, and the activated gel composition may include a pH adjusting agent, an additional binder, and a third solvent.
  • the pH adjusting agent may include sodium hydroxide, sodium carbonate, sodium bicarbonate, potassium carbonate, tris (hydroxymethyl) aminomethane, triethanolamine, or a combination thereof.
  • the activated gel composition may include 100 parts by weight of the pH adjuster, 4 to 350 parts by weight of the additional binder and 500 to 950 parts by weight of the third solvent.
  • the amount of the dental whitening agent may be 3 to 35 parts by weight based on 100 parts by weight of the total weight of the whitening gel composition and the activated gel composition.
  • a tooth whitening method comprising applying the multi-part tooth whitening composition to a tooth surface.
  • the tooth whitening method includes applying the activating liquid composition to the tooth surface to obtain a first treatment surface, and applying the whitening gel composition or a mixture of the whitening gel composition and the activating gel composition to the first treatment surface. It may include the step.
  • the multi-part tooth whitening composition according to the embodiment of the present invention may obtain an effective whitening effect even when the low concentration of the whitening agent is included, even with a small number of uses within a short time compared to the conventional self-whitening composition.
  • FIG. 1 is a photograph showing the whitening effect of the multi-part tooth whitening composition according to an embodiment of the present invention.
  • Figure 2 is a photograph showing the degree of oral mucosal irritations of the multi-part tooth whitening composition according to an embodiment of the present invention.
  • a multi-part tooth bleaching composition according to one embodiment of the present invention includes a whitening gel composition and an activating liquid composition.
  • multipart tooth whitening composition means a tooth whitening composition comprising two or more compositions physically separated from each other.
  • the whitening gel composition comprises a dental whitening agent, a binder and a first solvent.
  • the activating liquid composition includes a metal component and a second solvent for promoting decomposition of the dental whitening agent.
  • the whitening gel composition and the activating liquid composition are physically separated from each other in order to maintain the chemical stability of the dental whitening agent before being used for teeth whitening, and when used for teeth whitening, are sequentially applied to the surface of the teeth and contacted with each other.
  • the decomposition reaction ie, oxidation or ionization reaction
  • the dental whitening agent After the dental whitening agent is decomposed, it serves to remove the coloring component by reacting with the coloring component (for example, protein) present on the tooth surface.
  • the coloring component for example, protein
  • the dental whitening agent may include peroxide, hypochlorite, percarbonate, peroxide or a combination thereof.
  • the peroxide may include hydrogen peroxide, sodium peroxide, potassium peroxide, carbamide peroxide, sodium perborate, sodium percarbonate, or a combination thereof.
  • the hypochlorite may include sodium hypochlorite, potassium hypochlorite, calcium hypochlorite, barium hypochlorite, or a combination thereof.
  • the percarbonate may include sodium percarbonate, potassium percarbonate or a combination thereof.
  • the peroxide may include acetic acid peroxide, monophosphate peroxide, diphosphate peroxide, monosulfate peroxide, persulfate peroxide, nitric peroxide or a combination thereof.
  • the binder serves to bind the components of the whitening gel composition.
  • the binder may include a polymer.
  • the polymer may have a weight average molecular weight of 500,000 ⁇ 4,000,000.
  • the binder may include an ionic polymer, a nonionic polymer, or a combination thereof.
  • the ionic polymer may include carboxymethyl cellulose, carboxypropyl cellulose, or a combination thereof.
  • the nonionic polymer is polyvinyl alcohol, polyvinylpyrrolidone, hydroxyethyl cellulose, hydroxypropyl cellulose, polyacrylic acid, or a combination thereof. It may include.
  • the first solvent serves to dissolve the dental whitening agent and the binder.
  • Such first solvent may comprise water, ethanol or a combination thereof.
  • the whitening gel composition may include 100 parts by weight of the dental whitening agent, 30 to 1,700 parts by weight of the binder and 300 to 3,200 parts by weight of the first solvent.
  • the viscosity of the whitening gel composition is appropriate so that the whitening gel composition is not easily diluted or lost by saliva or the like. It can be easily applied to, and may have excellent phase stability.
  • the whitening gel composition may further include other additives such as fragrance, hypersensitivity treatments, dental caries inhibitors, gum disease improvers or combinations thereof.
  • the fragrance may include peppermint, spearmint, citrus, herbs, menthol or a combination thereof.
  • the hypersensitivity treatment agent potassium nitrate (potassium nitrate), tin fluoride (stannous fluoride), sodium monofluoride phosphate (MFP), sodium fluoride (NaF: sodium fluoride), sodium fluoride (Na 2 SiF 6 : sodium silicofluoride) or a combination thereof.
  • the dental caries suppressor may include sodium fluoride (NaF), calcium fluoride (CaF 2 ) or a combination thereof.
  • the gum disease improving agent is bamboo salt, tocopherol acetate, vitamin D, allantoin chlorohydroxy aluminum, triclosan, xylitol, calcium glycophosphate, aminocaproic acid, KNO 3 , sodium monofluoro It may include phosphate (sodium monofluorophosphate), enzyme (enzyme) or a combination thereof.
  • the content of the other additives may be appropriately adjusted within a range capable of improving the usability and functionality of the whitening gel composition without seriously changing the shape and stability of the whitening gel composition.
  • the activating liquid composition has an affinity with the constituents of the enamel (eg, an inorganic component), so that when it is applied to the tooth surface, it easily moves toward the enamel.
  • the activating liquid composition applied to the enamel serves to help the whitening gel composition to move easily toward the enamel.
  • the metal component (particularly, metal ions) in the activating liquid composition may increase the tooth whitening effect by helping to effectively dissolve the dental whitening agent applied to the tooth surface to effectively remove the coloring component deep in the enamel.
  • the metal component in the activating liquid composition promotes the disintegration of the dental whitening agent, thereby activating teeth whitening, and even when a low concentration (about 3% by weight of the total weight of the whitening gel composition and the activating gel composition) is used for the dental whitening agent. It serves to enable fast and effective whitening of teeth.
  • the metal component included in the activating liquid composition may be derived from a metal salt.
  • Such metal components may be metal ions, core metals that form chelate compounds, or combinations thereof.
  • the metal salt may include iron salt, calcium salt, magnesium salt, copper salt or a combination thereof.
  • the present invention is not limited thereto, and the metal salt may include other transition metal salts and / or other alkali metal salts.
  • the iron salt is iron (II) chloride, iron (III) chloride, iron bromide, iron sulfate, iron nitrate, iron acetate (II), iron propionate, iron citrate, iron gluconate, iron lactate, iron oxide, iron hydroxide, hydrates thereof, and these It may include at least one compound selected from the group consisting of ferric salts and ferrous salts of the mixture of.
  • the magnesium salt may include magnesium phosphate, magnesium nitrate, magnesium acetate, magnesium chloride, magnesium carbonate, magnesium sulfate, magnesium gluconate, magnesium hydroxide, or a combination thereof.
  • the copper salt includes copper pyrophosphate, copper sulfate, copper nitrate, copper acetate (II), copper chloride (I), copper chloride (II), copper carbonate (CuCO 3 ), copper gluconate, copper hydroxide, or a combination thereof. can do.
  • the second solvent may be the same as or similar to the first solvent.
  • the activation liquid composition may further include a chelating agent.
  • the chelating agent is intended to prevent the reduction of metal ions included in the activating liquid composition (for example, the reaction of metal ions with hydroxyl groups present on the tooth surface) and the precipitation of metals. That is, the chelating agent coordinates with the metal ion to form a chemically stable chelating compound.
  • the chelating agent may include EDTA (ethylenediaminetetraacetic acid), sodium citrate, bisphosphonate, EGTA (ethyleneglycoltetraacetic acid), ethylenediamine, auxin, orthophenanthrone, or a combination thereof.
  • the activating liquid composition may further include the other additives.
  • the activation liquid composition may have a metal ion concentration of 0.05 to 1 mM.
  • the center metal of the chelate compound is also included in the concentration calculation of the metal ion. If the metal ion concentration is within the above range, an excellent tooth whitening effect can be obtained without the occurrence of additional coloring caused when excessive metal ions are present.
  • the content of the activating liquid composition may be 5 to 100 parts by weight based on 100 parts by weight of the whitening gel composition.
  • the content of the activating liquid composition is within the above range with respect to 100 parts by weight of the whitening gel composition, an excellent tooth whitening effect may be obtained without additional coloring caused when excessive metal ions are present.
  • the multipart tooth whitening composition may further include an activated gel composition.
  • the activated gel composition is physically separated from the whitening gel composition to maintain the chemical stability of the dental whitening agent before it is used for teeth whitening, and when used for teeth whitening, it is mixed with the whitening gel composition to the whitening agent Further accelerate the decomposition reaction of the whitening effect.
  • the activating gel composition is also physically separated from the activating liquid composition before being used for tooth whitening.
  • the activating liquid composition is filled in a single syringe, and the whitening gel composition and the activating gel composition are each placed in two tubes of a dual syringe equipped with a mixing tip. It can be used for whitening teeth after being filled separately.
  • the activating gel composition is mixed with the whitening gel composition at the time of tooth whitening, and then further applied to the tooth surface to which the activating liquid composition is already applied to maximize the decomposition of the dental whitening agent at the tooth surface. And effective whitening of teeth.
  • the activated gel composition may comprise a pH adjusting agent, an additional binder and a third solvent.
  • the pH adjusting agent serves to promote decomposition of the dental whitening agent.
  • pH adjusting agents may include sodium hydroxide, sodium carbonate, sodium bicarbonate, potassium carbonate, tris (hydroxymethyl) aminomethane, triethanolamine or combinations thereof.
  • the additional binder may be the same as or similar to the binder.
  • the third solvent may be the same as or similar to the first solvent.
  • the activated gel composition may include 100 parts by weight of the pH adjuster, 4 to 350 parts by weight of the additional binder and 500 to 950 parts by weight of the third solvent.
  • the viscosity of the activated gel composition is appropriate so that the activated gel composition is not easily diluted or lost by saliva, It can be easily applied and can have excellent phase stability.
  • the content of the activated gel composition may be 50 to 150 parts by weight based on 100 parts by weight of the whitening gel composition.
  • the pH of the mixture of the whitening gel composition and the activated gel composition is moderate, which is excellent in human safety, and the dental whitening agent is sufficiently decomposed. Can be.
  • the amount of the dental whitening agent may be 3 to 35 parts by weight based on 100 parts by weight of the total weight of the whitening gel composition and the activated gel composition.
  • the content of the dental whitening agent is within the range based on 100 parts by weight of the total weight of the whitening gel composition and the activating gel composition, it is possible to obtain excellent tooth whitening effect without fear of tooth syring symptoms and gingival damage.
  • Another embodiment of the present invention provides a tooth whitening method comprising applying the multi-part tooth whitening composition to a tooth surface.
  • the tooth whitening method includes applying the activation liquid composition to the tooth surface to obtain a primary treatment surface and applying the whitening gel composition, or a mixture of the whitening gel composition and the activation gel composition to the primary treatment surface. It may include a step.
  • the activating liquid composition When applying the activating liquid composition to the tooth surface, the activating liquid composition may be applied by filling it with a single syringe and then releasing it into a brush.
  • the whitening gel composition may be filled into a single syringe and then discharged to a brush to apply the whitening gel composition.
  • the whitening gel composition when applying a mixture of the whitening gel composition and the activating gel composition to the primary treatment surface, the whitening gel composition is filled into one tube of a dual syringe equipped with a mixing tip, and the activating gel composition is After filling the other tube of the dual syringe, the plunger can be pressed to mix the two compositions and then the mixture can be applied to the brush by releasing it.
  • a whitening gel composition was prepared by mixing 100 parts by weight of hydrogen peroxide, 83.3 parts by weight of polyacrylic acid (Sigma Aldrich, Carbomer, weight average molecular weight: 3,000,000) and 1,483 parts by purified water.
  • Ferric chloride (II) was dissolved in purified water to prepare an activating liquid composition having an iron ion concentration of 0.2 mM.
  • a whitening gel composition was prepared by mixing 100 parts by weight of hydrogen peroxide, 83.3 parts by weight of polyacrylic acid (Sigma Aldrich, Carbomer, weight average molecular weight: 3,000,000) and 1,483.6 parts by weight of purified water.
  • An activated gel composition was prepared by mixing 100 parts by weight of sodium carbonate, 33.3 parts by weight of polyacrylic acid (Sigma Aldrich, Carbomer, weight average molecular weight: 3,000,000) and 533.3 parts by weight of purified water.
  • Ferric chloride (II) was dissolved in purified water to prepare an activating liquid composition having an iron ion concentration of 0.1 mM.
  • 100 parts by weight of the whitening gel composition was filled into one tube of a dual syringe (Sulazer, Double Syringe 5ml, 1: 1) equipped with a mixing tip, 100 parts by weight of the activated gel composition was filled into the other tube of the dual syringe, 50 parts by weight of the activating liquid composition was filled in a single syringe (Norm-Ject, syringe 2mL) to prepare a three-part tooth whitening composition.
  • the hydrogen peroxide content in the three-part tooth whitening composition thus prepared was 3 parts by weight based on 100 parts by weight of the total weight of the whitening gel composition and the activated gel composition.
  • each whitened tooth was visually observed to evaluate the whitening effect according to the VITA Shade Classical Guide.
  • the application of the three-part tooth whitening composition was carried out in the following manner: (i) The activating liquid composition was applied to each of the teeth with a brush. (ii) A mixture of the whitening gel composition and the activating gel composition was applied to each of the teeth with a brush and left for 10 minutes. (I) and (ii) were repeated three more times.
  • photographs of the teeth before the whitening treatment and the teeth after the whitening treatment are shown in FIG. 1. In FIG. 1, (a) rows are teeth before the whitening treatment, and (b) rows are the teeth after the whitening treatment.
  • the whitening treatment was carried out for a short time within 60 minutes with a whitening composition containing hydrogen peroxide at a low concentration (that is, 3 parts by weight based on 100 parts by weight of the total weight of the whitening gel composition and the activating gel composition),
  • the whitening teeth were improved by one or two shade steps compared to the teeth before whitening.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition de blanchiment dentaire à plusieurs constituants et un procédé de blanchiment dentaire. La composition de blanchiment dentaire à plusieurs constituants selon l'invention comprend une composition de gel de blanchiment et une composition d'activation liquide, la composition de gel de blanchiment contenant un agent de blanchiment dentaire, un liant et un premier solvant, et la composition d'activation liquide contenant un constituant métallique destiné à accélérer la décomposition de l'agent de blanchiment dentaire et un second solvant.
PCT/KR2014/000936 2013-02-18 2014-02-04 Composition de blanchiment dentaire à plusieurs constituants et procédé de blanchiment dentaire WO2014126350A1 (fr)

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KR1020130016984A KR101514014B1 (ko) 2013-02-18 2013-02-18 다부분 치아 미백 조성물 및 치아 미백 방법
KR10-2013-0016984 2013-02-18

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101650741B1 (ko) * 2015-11-09 2016-08-31 이큐맥슨제약 주식회사 치아 미백용 코팅막 형성제 및 치아 미백 코팅막을 형성하는 방법
WO2020112365A1 (fr) * 2018-11-27 2020-06-04 Colgate-Palmolive Company Compositions à deux composants pour le blanchiment des dents

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040095898A (ko) * 2003-04-29 2004-11-16 애경산업(주) 치아 미백용 첩포제
WO2005041911A1 (fr) * 2003-10-24 2005-05-12 Orapro, Inc Procede, composition et trousse de blanchiment accelere des dents
KR20050103491A (ko) * 2003-02-05 2005-10-31 코리움 인터네셔널 치아 미백용 하이드로겔 조성물
KR100550065B1 (ko) * 2002-07-24 2006-02-08 주식회사 태평양 하이드로젤 매트릭스 부착 치아 미백용 패취

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100550065B1 (ko) * 2002-07-24 2006-02-08 주식회사 태평양 하이드로젤 매트릭스 부착 치아 미백용 패취
KR20050103491A (ko) * 2003-02-05 2005-10-31 코리움 인터네셔널 치아 미백용 하이드로겔 조성물
KR20040095898A (ko) * 2003-04-29 2004-11-16 애경산업(주) 치아 미백용 첩포제
WO2005041911A1 (fr) * 2003-10-24 2005-05-12 Orapro, Inc Procede, composition et trousse de blanchiment accelere des dents

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101650741B1 (ko) * 2015-11-09 2016-08-31 이큐맥슨제약 주식회사 치아 미백용 코팅막 형성제 및 치아 미백 코팅막을 형성하는 방법
WO2017082526A1 (fr) * 2015-11-09 2017-05-18 이큐맥슨제약 주식회사 Agent pour former un film de revêtement de blanchiment de dent, et procédé pour former un film de revêtement de blanchiment de dent
WO2020112365A1 (fr) * 2018-11-27 2020-06-04 Colgate-Palmolive Company Compositions à deux composants pour le blanchiment des dents

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KR101514014B1 (ko) 2015-04-23

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