WO2020130164A1 - Composition d'hygiène buccale - Google Patents

Composition d'hygiène buccale Download PDF

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Publication number
WO2020130164A1
WO2020130164A1 PCT/KR2018/016051 KR2018016051W WO2020130164A1 WO 2020130164 A1 WO2020130164 A1 WO 2020130164A1 KR 2018016051 W KR2018016051 W KR 2018016051W WO 2020130164 A1 WO2020130164 A1 WO 2020130164A1
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Prior art keywords
group
disease
oral
eugenol
composition
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PCT/KR2018/016051
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English (en)
Korean (ko)
Inventor
유정헌
이상화
임준만
Original Assignee
주식회사 엘지생활건강
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Priority to PCT/KR2018/016051 priority Critical patent/WO2020130164A1/fr
Publication of WO2020130164A1 publication Critical patent/WO2020130164A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A61K8/21—Fluorides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings

Definitions

  • the present invention relates to an oral hygiene composition having excellent preventive and therapeutic effects on bad breath, toothache, stomatitis, gingivitis, periodontitis, syringitis, dental caries, periodontal disease, pulp disease and apical disease.
  • Dental caries and periodontal disease among oral diseases are known as the main factors that cause various clinical symptoms such as pain, chewing dysfunction, periodontal tissue destruction, bad breath and pain, and cause tooth loss.
  • the causative factor is increasing.
  • antibiotics have the disadvantage that they can be used only as therapeutic agents because they are difficult to use for a long time because they can induce the appearance of mycobacterium-resistant bacteria and alternation of oral bacteria in addition to systemic side effects on the body.
  • antibacterial agents used in oral cleansing agents include saline guinarine, listerine, pyroxide, chlorhexidine, etc. Saengquinarine has an unclear effect on bacteria in the oral cavity and is more unclear about the treatment effect in periodontal disease.
  • Listerine is a main component of alcohol, which has a temporary effect in the oral cavity, but has some bacteriostatic effects, but also has a disadvantage in that it may have a harmful effect on tissues when used for a long time.
  • Pyroxide (Peroxide) which is being added for the whitening effect, has a poisonous effect on bacteria, but at the same time has a poisonous effect on human tissues, and also has safety problems, and sometimes bacteria resistant to pyroxide appear in bacteria.
  • chlorhexidine is known to be the best among the formulations known to date as a preventive and therapeutic agent for periodontal disease in addition to inhibition of plaque formation, but it has a strong irritating and odorous side effect.
  • mycosis which can also cause carcinogenicity, and limited use in pregnant women.
  • the present invention is to provide an oral hygiene composition excellent in antibacterial effect, excellent in the prevention, improvement and treatment of bad breath, toothache, stomatitis, gingivitis, periodontitis, syringitis, dental caries, periodontal disease, pulp disease and apical disease.
  • the present invention provides an oral hygiene composition comprising any one or more selected from the group consisting of saccharin, fluorine, calcium carbonate and silica and eugenol as an active ingredient.
  • the composition of the present invention is characterized in that it is for preventing, alleviating or treating oral diseases.
  • the oral disease is characterized in that it is at least one selected from the group consisting of bad breath, toothache, stomatitis, gingivitis, periodontitis, acute teeth, dental caries, periodontal disease, pulp disease and apical disease.
  • any one or more selected from the group consisting of the saccharin, fluorine, calcium carbonate, and silica is characterized by being mixed with eugenol in a weight ratio of 1:0.1 to 10.
  • any one or more selected from the group consisting of the saccharin, fluorine, calcium carbonate and silica is characterized in that it contains 0.001 to 0.1% by weight based on the total weight of the composition.
  • the eugenol is characterized in that it comprises 0.001 to 0.1% by weight based on the total weight of the composition.
  • the composition is characterized in that it has an antibacterial effect in the genus Streptococcus (Streptococcus) or in Porphyromonas (Porphyromonas).
  • Streptococcus genus or Porphyromonas genus Streptococcus mutans Streptococcus sanguis, Streptococcus sanguinis, Streptococcus sanguinis, Streptococcus salivaus Streptococcus salivariussubsp. thermophils
  • one or more selected from the group consisting of Porphyromonas gingivalis one or more selected from the group consisting of Porphyromonas gingivalis.
  • an oral product comprising the aforementioned oral hygiene composition.
  • the oral product of the present invention is characterized by being selected from the group consisting of toothpaste, gargling product, gum, oral spray, oral ointment, mouthwash and mouthwash.
  • the present invention has excellent antibacterial effect, exerts excellent effects on the prevention, improvement and treatment of bad breath, toothache, stomatitis, gingivitis, periodontitis, syringitis, dental caries, periodontal disease, pulp disease and apical disease.
  • the present invention is oral hygiene containing any one or more selected from the group consisting of saccharin (Sacharine), fluorine (F), calcium carbonate (CaC0 3 ) and silica (Silica) and eugenol (Eugenol) Provided is a composition.
  • the composition of the present invention is characterized in that it is for preventing, alleviating or treating oral diseases.
  • the oral disease is, for example, but is not limited to bad breath, acute teeth, dental caries, gingivitis, periodontitis, mucosal ulcers in the oral cavity, and apical disease.
  • prevention refers to any act of suppressing or delaying the disease using the oral hygiene composition.
  • treatment refers to all actions in which symptoms of the disease are alleviated or cured using the oral hygiene composition.
  • treating means that the symptoms of oral disease such as the above are reduced or softened, and can be understood as a broad concept including improvement, prevention, and treatment.
  • the term “improvement” can be understood as a broad concept that means to recover symptoms close to the original condition by treating oral diseases and the like.
  • the oral disease is characterized in that it is at least one selected from the group consisting of bad breath, toothache, stomatitis, gingivitis, periodontitis, acute teeth, dental caries, periodontal disease, pulp disease and apical disease.
  • halt breath is not limited to this, but due to acquired systemic disease, protein in saliva, food debris, etc., is decomposed by microorganisms in the oral cavity to decompose, resulting in odor It can be caused by generating substances.
  • the primary cause of bad breath is not limited to microorganisms in the oral cavity, but is not limited to the genus Streptococcus , genus Porphyromonas , Actinomyces genus, Actinobacillus genus, etc. This can be.
  • toothache most commonly occurs due to structural damage to the teeth, where dental nerves, which are usually well protected by dentin and enamel, are not only the result of caries, tooth cracking, tooth root exposure or enamel erosion. In addition, it is exposed to external stimuli by gingival diseases, abscesses or ambushes.
  • the term “stomatitis” is also referred to as mucosal ulcer in the oral cavity, but is not limited thereto, due to infection by bacteria, viruses, fungi, etc. in the oral cavity (hymen, gums, lips, cheeks inside) Etc.) refers to a disease in which inflammation occurs, and the bacteria may be bacteria such as the genus Streptococcus and the genus Porphyromonas.
  • the term “gingivitis” and “gingivitis” are not limited to this, but the bacteria, such as the genus Streptococcus, Porphyromonas, which are present in the subgingival plaque, have appropriate growth conditions. When it is formed, it may be an oral disease that causes inflammation of the gums by developing an infection in the soft tissues of the gingival area and developing a periodontal disease of gingivitis or periodontitis.
  • the term "syrinyi” means, but is not limited to, cavities or other pathological causes, apart from external stimulation, refers to any phenomenon that appears sharp, temporary or persistent pain.
  • the external stimulus usually refers to a temperature stimulus, and usually complains of a symptom in a cold temperature stimulus.
  • pain may also be caused by stimulation such as drying of the teeth, contact with foreign substances, osmotic pressure through sweet or sour food. It may appear throughout the entire tooth, and may be limited to certain areas, such as the maxilla or mandible, or the right or left side, and may be accompanied by dentin hyperesthesia, caries, and pulp inflammation.
  • the exposure of the mouth of the ivory tubule may be considered.
  • enamel or cementite is destroyed and the entrance of the ivory tubules is exposed to the outside, stimulation is transmitted to the pulp by the cell processes, nerves, and dentin fluid of the ivory tubules, and pain can be felt.
  • tooth caries refers to a lesion in which the hard tissue of a tooth is destroyed by bacteria (Streptococcus mutans, etc.) in the dental bacterial membrane attached to the surface of the tooth, an inorganic component of hemorrhoids by organic acids produced by bacteria (Calcium salt) is demineralized, and the organic component is decomposed again by enzymes from bacteria.
  • bacteria Streptococcus mutans, etc.
  • Calcium salt organic acids produced by bacteria
  • the bacteria that cause dental caries may be of the genus Streptococcus , of the genus Porphyromonas , and the like.
  • gingivitis is divided into gingivitis and periodontitis
  • gingivitis is an inflammatory lesion confined to the gingiva
  • periodontitis is a lesion occurring on the periodontal ligament and alveolar bone including gingivitis.
  • periodontal disease is divided into acute periodontitis and periodontal disease.
  • the term definition is correct in terms of the location where apical periodontitis occurs, it is most often referred to as apical disease in clinical practice.
  • the term "dimension disease” is divided into inflammatory lesions and non-inflammatory lesions, and inflammatory lesions include degenerative lesions such as pulpitis, non-inflammatory lesions, atrophy, degeneration, and necrosis.
  • the pulp is a plastic connective tissue with blood vessels and nerves distributed around it, surrounded by calcified dentin. During inflammation, blood vessels become congested and pulp tissue swells due to edema, which increases the internal pressure of the pulp, so inflammation of the pulp tissue progresses faster and pain is worse than other tissues.
  • apical disease is an inflammatory lesion occurring in the periodontal tissue around the apical tip, which occurs when there is insufficient open-mouth pulpitis, pulp necrosis or pulp gangrene, root canal treatment, or low toxicity bacteria.
  • the oral hygiene composition of the present invention is any one or more selected from the group consisting of saccharin, fluorine, calcium carbonate, and silica eugenol and a weight ratio of 1: 0.1 to 10, specifically 1: 0.5 to It may be included in a weight ratio of 5, more specifically 1: a weight ratio of 0.3 to 3, and most specifically, a weight ratio of 1:1.
  • any one or more selected from the group consisting of saccharin, fluorine, calcium carbonate and silica is 0.001 to 0.1% by weight, specifically 0.001 to 0.05% by weight, more specifically 0.005 to 0.01, based on the total weight of the composition It may be included in weight percent.
  • the ratio of the remaining components compared to any one component is 1:0.1 to It may be included in a weight ratio of 10, specifically 1: 0.1 to 5, and more specifically 1: 0.5 to 3.
  • eugenol may be included in an amount of 0.001 to 0.05% by weight, specifically 0.001 to 0.05% by weight, and more specifically 0.005 to 0.01% by weight based on the total weight of the composition.
  • any one or more selected from the group consisting of saccharin, fluorine, calcium carbonate and silica and eugenol when included in the composition of the present invention any one selected from the group consisting of saccharin, fluorine, calcium carbonate and silica
  • the ratio of eugenol may be included in a weight ratio of 1:0.1 to 10, specifically 1:0.1 to 5, and more specifically 1:0.5 to 3.
  • the oral hygiene composition of the present invention has an excellent antibacterial effect in Streptococcus or Porphyromonas and has excellent effects in preventing and treating oral diseases.
  • the oral hygiene composition of the present invention includes Streptococcus or Streptococcus mutans, Streptococcus sanguis, Streptococcus sanguinis, Streptococcus sanguinis, Streptococcus sanguinis It can exert an antibacterial effect on one or more selected from the group consisting of Streptococcus salivariussubsp. thermophils, and Porphyromonasgingivalis.
  • Oral hygiene composition of the present invention in addition to the above-mentioned components, as a component in general according to the formulation and purpose of use, we may further include a wetting agent, abrasives, agonists, sweeteners, pH adjusting agents, preservatives, binders, flavoring agents, foaming agents and the like. .
  • Wetting agents are used alone or in a mixture of concentrated glycerin, glycerin, sorbitol aqueous solution, amorphous sorbitol aqueous solution, polyethylene glycols, and propylene glycol, and the amount used may be 1 to 70% by weight based on the total weight of the oral hygiene composition .
  • the abrasive is selected from the group consisting of precipitated silica, silica gel, zirconium silicate, calcium monohydrogen phosphate, calcium monohydrogen phosphate, hydrous alumina, light calcium carbonate, heavy calcium carbonate, calcium pyrophosphate, insoluble metaphosphate, and aluminum silicate. Etc. can be used.
  • the amount of the abrasive may be generally 1 to 60% by weight based on the total weight of the oral hygiene composition.
  • additives used in a small amount may include sweeteners, pH adjusters, preservatives, colorants, and binders as commonly used components.
  • binder sodium carboxymethylcellulose, carbomer, carrageenan, xanthan gum, alginate, and the like can be used.
  • foaming agent anionic and nonionic surfactants such as sodium alkylsulfate, sodium lauryl sulfate, sucrose fatty acid ester, and sorbitan fatty acid ester can be used. It can be used alone or in combination of two or more.
  • the amount of the binder used is generally 0.1 to 3% by weight based on the total weight of the oral hygiene composition, and may preferably be 0.5 to 2% by weight.
  • Saccharin, xylitol, erythritol, aspartame, etc. may be used as the sweetener, and the amount of the sweetener may be 0.05 to 2% by weight based on the total weight of the oral hygiene composition.
  • sodium phosphate sodium phosphate, disodium phosphate, citric acid, triethanolamine, and the like can be used.
  • benzoic acid methylparaben, propylparaben, sodium benzoate, etc.
  • benzoic acid methylparaben, propylparaben, sodium benzoate, etc.
  • benzoic acid methylparaben, propylparaben, sodium benzoate, etc.
  • a fragrance peppermint oil, spearmint oil, and menthol may be used in combination, and enzymes such as dextranase may be used as other additives.
  • foaming agent anionic surfactant sodium lauryl sulfate, copolymer of nonionic surfactant polyoxyethylene polyoxypropylene (poloxamer), polyoxyethylene cured castor oil, polyoxyethylene sorbitan fatty acid ester, etc. may be used. .
  • the amount of the foaming agent is generally 0.5 to 5% by weight based on the total weight of the oral hygiene composition, preferably 0.5 to 3.5% by weight.
  • the present invention provides an oral hygiene composition for preventing or improving oral diseases comprising eugenol and any one or more selected from the group consisting of saccharin, fluorine, calcium carbonate and silica, which can be used for oral hygiene.
  • the oral hygiene composition include a food composition and a pharmaceutical composition (including quasi-drug composition), specifically, toothpaste, mouthwash, oral spray, oral ointment, gum, and the like.
  • a food composition for preventing or improving oral diseases comprising at least one selected from the group consisting of saccharin, fluorine, calcium carbonate, and silica and eugenol as an active ingredient.
  • examples of the food composition of the present invention include food, food additives, beverages or beverage additives.
  • the food composition of the present invention can exert a preventive and improving effect on any one or more oral diseases selected from the group consisting of bad breath, toothache, stomatitis, gingivitis, periodontitis, sirin, dental caries, periodontal disease, pulp disease and apical disease have.
  • a pharmaceutical composition for the prevention, improvement or treatment of oral diseases comprising at least one selected from the group consisting of saccharin, fluorine, calcium carbonate and silica and eugenol as an active ingredient.
  • the pharmaceutical composition of the present invention prevents, improves and treats at least one oral disease selected from the group consisting of bad breath, toothache, stomatitis, gingivitis, periodontitis, syringitis, dental caries, periodontal disease, pulp disease and apical disease Can be exercised.
  • an oral product comprising the aforementioned oral hygiene composition.
  • the oral hygiene composition according to the present invention is an oral hygiene composition that can be generally included in products manufactured and marketed for oral health, and there is no limitation on the applied oral products.
  • the oral product of the present invention is characterized by being selected from the group consisting of toothpaste, gargling product, gum, oral spray, oral ointment, mouthwash and mouthwash.
  • the paper disk test method is used to determine whether it has the effect of inhibiting strains using Gram-positive bacteria Streptococcus mutans and Gram-negative bacteria Porphyromonas gingivalis , which are representative caries and dental periodontal bacteria. Antibacterial activity test was conducted.
  • Each of the above bacteria after cultivating activity under the optimum culture conditions in Table 1, was cultured for 4 to 6 hours in the optimum medium of each bacterium to increase the turbidity of the culture medium in Macfarland turbidity No. After adjusting to 0.5 (1.5x10 8 ), 0.1 ml was spread evenly. After sterilizing paper disks (Whatman no.5 paper, 8mm diameter), the total concentration of treatment of each material was inoculated at a concentration of 10mg/disc and absorbed and dried for 1 hour. After culturing 24-48 hours at the optimum temperature of each bacterium, the size (diameter mm) of the growth inhibition ring was measured.
  • both the experimental groups a1 to a10 exhibited excellent growth-inhibiting effects against Streptococcus mutans and Popyromonas gingivalis compared to the untreated group a, especially eugenol, saccharin, fluorine, calcium carbonate, or silica, respectively.
  • the growth inhibition effect was all excellent, especially in the experimental group a10 treated with all the active ingredients.
  • PGE2 prostaglandin E2
  • DMEM Dulbecco's Modified Eagle's Medium
  • FBS fetal bovine serum
  • a control toothpaste was made using ingredients that can be generally used to prepare a toothpaste, and an example toothpaste containing each substance was prepared therein.
  • test subjects were gingival inflammatory patients who had even dentition and no missing teeth. 30 subjects were selected from 30 to 50 years of age, followed by precise oral checkups by 30 people according to gender. A clinical trial was conducted on the treatment effect of gingivitis.
  • the experimental group was divided into the experimental group and the control group, and was educated to use 3 times a day before going to sleep after 2 hours after eating, and scored the initial gingivitis index by performing a face wash, and used each toothpaste composition for 1 week, 1 month, 3 After months and 6 months, oral examinations were conducted to examine the gingivitis index.
  • the method of measuring the gingivitis index is by inserting a periodontal probe into the gingival fissure, burning the probe around each tooth without applying force, and measuring the bleeding condition after 30 seconds. Recorded to obtain results.
  • Experiment group c10 0 weeks 1.05 1.04 1.05 1.04 1.06 1.05 1.05 1.04 1.05 1.06 1 week 1.60 1.15 1.45 1.41 1.35 1.40 1.11 1.11 1.10 1.12 1.08 1 month 2.63 1.17 2.00 1.18 2.01 2.10 1.15 1.15 1.15 1.16 1.10 3 months 2.79 1.19 2.35 2.25 2.18 2.32 1.18 1.19 1.17 1.17 1.12 6 months 2.87 1.23 2.52 2.48 2.39 2.40 1.21 1.19 1.20 1.21 1.15
  • the gingivitis index increased with exacerbation of gingival inflammation in the control group, while in the experimental groups c5 to c10 containing eugenol in saccharin, fluorine, calcium carbonate, silica, or a mixture thereof, both the control group, as well as eugenol, saccharin, fluorine, Compared to the calcium carbonate or silica treatment alone (experimental groups c1 to c5), the gingival index was lowered, thereby exhibiting excellent gingivitis improvement effect. In particular, in experimental group c10 containing all of eugenol, saccharin, fluorine, calcium carbonate, and silica It was confirmed that the degree of gingivitis index increase was the lowest, and the effect was also excellent after 6 months.
  • control and experimental group (Example) composition prepared above was compared to the degree of inhibition of the syringe. (See Table 3)
  • the test was conducted by measuring the patient's response after applying temperature stimulation. Before conducting the test, the hypersensitivity area of each candidate's perceptive hypersensitivity teeth was checked beforehand, and each composition was used 3 times a day for 2 weeks after dropping the cold water of about 5°C into the dropper of the tooth with a dropper for evaluation. After 2 weeks, the water was dropped again to a dropper of about 5°C with a dropper for evaluation. After stimulation, the criteria for the patient's response rating were set as follows. (0 point: no discomfort, 1 point: slightly uncomfortable or cold, 3 point: sick). Statistical treatment was tested by paired student-t test for stimulation scores before and 2 weeks after laboratory.
  • Experiment group c10 0 weeks 2.15 ⁇ 0.11 2.14 ⁇ 0.10 2.14 ⁇ 0.09 2.13 ⁇ 0.05 2.14 ⁇ 0.04 2.15 ⁇ 0.11 2.15 ⁇ 0.08 2.14 ⁇ 0.11 2.15 ⁇ 0.01 2.14 ⁇ 0.07 2.13 ⁇ 0.10 2 weeks 2.14 ⁇ 0.10 1.85 ⁇ 0.18 1.90 ⁇ 0.11 1.86 ⁇ 0.08 1.91 ⁇ 0.12 1.89 ⁇ 0.05 1.77 ⁇ 0.20 1.75 ⁇ 0.07 1.80 ⁇ 0.11 1.74 ⁇ 0.08 1.65 ⁇ 0.12 valence p>0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇ 0.05 *p ⁇
  • the control group had a decrease in index of only 0.01 points compared to the 0-week index, whereas all of the experimental groups c5 to c10 containing eugenol in saccharin, fluorine, calcium carbonate, silica, or mixtures thereof, as well as the control group, eugenol, saccharin, and fluorine , Compared to calcium carbonate or silica alone (experimental groups c1 to c5), superior syrin showed an improvement effect, and in particular, syrin decreased index in experimental group c10 containing all of eugenol, saccharin, fluorine, calcium carbonate, and silica. Was confirmed to be the highest.
  • the present invention is excellent as an antibacterial effect, bad breath, toothache, stomatitis, gingivitis, periodontitis, syringitis, dental caries, periodontal disease, ulcer disease and apical diseases, excellent effect in preventing, improving and treating it is useful as an oral hygiene composition Can be used.

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Abstract

La présente invention concerne une composition d'hygiène buccale comprenant, en tant que principes actifs, de l'eugénol et un ou plusieurs éléments choisis dans le groupe constitué par la saccharine, le fluor, le carbonate de calcium et la silice. La composition présente un excellent effet antibactérien et d'excellents effets sur la prévention, le soulagement et le traitement de la mauvaise haleine, du mal de dents, de la stomatite, de la gingivite, de la parodontite, des dents sensibles, des caries dentaires, d'une maladie parodontale, d'une maladie pulpaire et d'une maladie périapicale et peut donc être appliquée pour prévenir et traiter diverses maladies buccales.
PCT/KR2018/016051 2018-12-17 2018-12-17 Composition d'hygiène buccale WO2020130164A1 (fr)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100327886B1 (ko) * 1994-06-29 2002-08-01 라이온 가부시키가이샤 구강용조성물
JP2012509893A (ja) * 2008-11-25 2012-04-26 ザ プロクター アンド ギャンブル カンパニー 改善された審美性及び溶融シリカを有する、口腔ケア組成物
KR20130027751A (ko) * 2011-09-08 2013-03-18 동의대학교 산학협력단 정향유 또는 유제놀을 유효성분으로 포함하는 구강용 조성물
US20130295027A1 (en) * 2010-12-07 2013-11-07 Maya Treesa Saji Oral care composition

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100327886B1 (ko) * 1994-06-29 2002-08-01 라이온 가부시키가이샤 구강용조성물
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