WO2017119660A1 - Composition de blanchiment des dents ayant une stabilité améliorée - Google Patents

Composition de blanchiment des dents ayant une stabilité améliorée Download PDF

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Publication number
WO2017119660A1
WO2017119660A1 PCT/KR2016/015357 KR2016015357W WO2017119660A1 WO 2017119660 A1 WO2017119660 A1 WO 2017119660A1 KR 2016015357 W KR2016015357 W KR 2016015357W WO 2017119660 A1 WO2017119660 A1 WO 2017119660A1
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WO
WIPO (PCT)
Prior art keywords
tooth whitening
whitening composition
peroxide
weight
sodium
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PCT/KR2016/015357
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English (en)
Korean (ko)
Inventor
신승화
최다미
송주동
엄태관
최규옥
Original Assignee
오스템임플란트 주식회사
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Priority to TW106100130A priority Critical patent/TWI682784B/zh
Publication of WO2017119660A1 publication Critical patent/WO2017119660A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22—Peroxides; Oxygen; Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures

Definitions

  • the present invention relates to a tooth whitening composition, and more particularly, the tooth whitening agent which can inhibit the degradation of peroxide as a whitening functional active ingredient by phytic acid, improve the pH stability of the composition, and continue to exert a whitening effect even during long-term storage. It relates to a composition.
  • the tooth is composed of the inner dentin and the outer enamel as a protective wall of the tooth.
  • the color of the enamel is originally opaque white or yellow.
  • the enamel has natural spaces or holes, in which some coloring matter or discolorant penetrates and causes discoloration of the teeth.
  • Peroxide-based tooth whitening agents currently used are known to oxidize pigments or stains present in teeth by free radicals from peroxides moving through the enamel layer and dentin of teeth. It is formulated in patch form and used.
  • the paste-type tooth whitening agent is convenient to use and inexpensive, so there are many users, but the contact time is short and the whitening effect is insufficient.
  • the liquid tooth whitening agent is a product that stabilizes the whitening component in the liquid, but is diluted with saliva in the oral cavity. The whitening effect may be lowered.
  • patch-type tooth whitening products are easier to use and more effective than paste- or liquid-based products, but are often crumpled or folded during storage, preventing the use of the product.
  • the product must be attached to the whole, there is a problem that the manufacturing method is difficult because the patch deformation process is added.
  • the peroxide has an excellent tooth whitening effect, but there is a problem in that the compatibility with a commonly used tooth whitening agent is not good and the long-term storage stability is lowered.
  • a commonly used tooth whitening agent contains a large amount of metal ions including iron (III) ions as impurities, and since these metal ions act as a catalyst to decompose peroxides, the peroxides decompose rapidly during storage and distribution. There is a problem such as expansion of the container or separation of the formulation due to gas generation.
  • tooth whitening agents using a substance capable of stabilizing a peroxide, a whitening functional active ingredient have been proposed in Korea Patent Registration No. 10-0870232, but this can ensure short-term stability while maintaining stability of peroxide in the long term. There is a problem that is difficult to maintain.
  • the present invention is to solve the above-mentioned problems of the prior art, an object of the present invention is to suppress the decomposition of peroxide by the metal ions released by the other components in the composition during storage and unnecessary pH change of the composition, when long-term storage It is to provide a tooth whitening composition which is excellent in stability and can continuously exert a whitening effect.
  • One aspect of the present invention provides a tooth whitening composition comprising 0.1 to 10% by weight of phytic acid or a salt thereof based on the total weight of the tooth whitening composition in the tooth whitening composition comprising a peroxide as an active ingredient.
  • the content of the peroxide may be 0.5 to 50% by weight based on the total weight of the tooth whitening composition.
  • the peroxide may be at least one selected from the group consisting of hydrogen peroxide, percarbonate, perborate, urea peroxide, sodium pyrophosphate, calcium peroxide, barium peroxide, magnesium peroxide, and potassium peroxide.
  • it may further comprise 1 to 10% by weight of the chelating agent based on the total weight of the tooth whitening composition.
  • the chelating agent in the group consisting of ethylenediamine tetra acetic acid and salts thereof, sodium stannate, potassium stannate, and pyrophosphate It may be one or more selected.
  • the pH whitening agent may further comprise 1 to 10% by weight based on the total weight of the composition.
  • the pH adjuster is dibasic sodium phosphate, tribasic sodium phosphate, sodium carbonate, sodium bicarbonate, sodium hydroxide, potassium hydroxide, potassium carbonate, ammonium hydroxide, triethanolamine, tris (hydroxymethyl) aminomethane, Citric acid, and sodium citrate.
  • the adhesive may further comprise 5 to 80% by weight of the adhesive polymer based on the total weight of the whitening agent composition.
  • the adhesive polymer may be polyvinylpyrrolidone having a K value of 12 to 120.
  • based on the total weight of the tooth whitening agent composition may further comprise 1 to 10% by weight of the surfactant.
  • the surfactant may be at least one selected from the group consisting of polyethylene glycol, propylene glycol, glycerin, triethyl citrate, and polysorbate.
  • Tooth whitening composition by inhibiting the decomposition of the peroxide which is a whitening functional active ingredient and unnecessary pH change of the composition by phytic acid, it is excellent in long-term storage stability and can continue to exhibit a whitening effect.
  • Figure 1 is a schematic of the pH stability evaluation results of the tooth whitening composition according to the examples and comparative examples of the present invention.
  • Figure 2 is a schematic of the peroxide stability evaluation results of the tooth whitening agent composition according to the Examples and Comparative Examples of the present invention.
  • One aspect of the present invention provides a tooth whitening composition comprising 0.1 to 10% by weight of phytic acid or a salt thereof based on the total weight of the tooth whitening composition in the tooth whitening composition comprising a peroxide as an active ingredient.
  • the term "active ingredient” means a component having direct whitening functionality among the components of the tooth whitening composition.
  • the whitening effect on the discolored tooth may be realized by free radicals generated from the peroxides moving through the enamel and dentin of the tooth to oxidize the pigment or stain present in the tooth.
  • the content of the peroxide may be 0.5 to 50% by weight, preferably 3 to 35% by weight based on the total weight of the tooth whitening agent composition. If the content of the peroxide is less than 0.5% by weight can not implement the required level of whitening effect, more than 50% by weight may be corroded tooth surface or damaged oral mucosa.
  • the peroxide may be at least one selected from the group consisting of hydrogen peroxide, percarbonate, perborate, urea peroxide, pyrophosphate pyrophosphate, calcium peroxide, barium peroxide, magnesium peroxide, and potassium peroxide, preferably hydrogen peroxide, but It is not limited.
  • the tooth whitening agent composition may include phytic acid or salts thereof (hereinafter, collectively referred to as 'phytic acid').
  • the phytic acid is a kind of organophosphate compound represented by the following Chemical Formula 1 and is also called myoinsitol hexaphosphate, and is a natural antioxidant extracted from the shell of grains, beans, and fruits such as rice, wheat, barley, and corn. It can be present as a salt (phytate) mainly associated with metal ions such as phosphorus, calcium, magnesium, zinc, iron, copper.
  • Examples of the salt of the phytic acid that can be used include sodium phytate such as monosodium phytate and disodium phytate, monopotassium phytate, dipotassium phytate and the like. Potassium phosphate, calcium phytate, and the like, but are not limited thereto.
  • the phytic acid binds to metal ions to form complexes, thus having a so-called "metal containment effect" which prevents various side effects that may occur when the metal ions come into contact with other components.
  • the tooth whitening agent contains a large amount of metal ions including iron (III) ions as impurities, and since these metal ions act as a catalyst for decomposing peroxides, the peroxides are rapidly decomposed during storage and distribution, so the whitening effect is difficult to sustain in the long term.
  • metal ions including iron (III) ions as impurities
  • iron (III) ions act as a catalyst for decomposing peroxides
  • the peroxides are rapidly decomposed during storage and distribution, so the whitening effect is difficult to sustain in the long term.
  • the container is expanded or the formulation is separated due to the generation of gas in the product.
  • the phytic acid may adsorb the metal ions to substantially inactivate the metal ions. That is, by preventing the peroxide directly exposed to the metal ions to delay or inhibit the decomposition of the peroxide by the reaction between them and to stabilize the pH of the composition, the chemical stability and storage stability of the tooth whitening composition can be improved. .
  • the content of the phytic acid may be 0.1 to 10% by weight based on the total weight of the tooth whitening composition. If the content of the phytic acid is less than 0.1% by weight, the metal blocking effect is weak, and if it is more than 10% by weight, the activity of the peroxide is excessively lowered so that a whitening effect of the required level cannot be realized.
  • the phytic acid since the affinity with the phytic acid may be relatively different depending on the kind of the metal ion present in the tooth whitening composition, the phytic acid may not have a metal blocking effect on all kinds of metal ions.
  • the tooth whitening composition may further include one or more chelating agents except for phytic acid to further adsorb and block metal ions not blocked by the phytic acid, and the content of the chelating agent may be determined by the total amount of the tooth whitening composition. It may be 1 to 10% by weight based on the weight. When the content of the chelating agent is less than 1% by weight, the stabilizing effect is weak, and when it is more than 10% by weight, ease of use may be lowered.
  • the chelating agent may be at least one selected from the group consisting of ethylenediamine tetra acetic acid and salts thereof, sodium stannate, potassium stannate, and pyrophosphate. It may preferably be one or more of ethylenediamine tetraacetic acid, sodium stenate, pyrophosphate, and more preferably may be a combination of ethylenediamine tetraacetic acid, sodium stenate, and pyrophosphate.
  • the pyrophosphate since the pyrophosphate has a tar removal effect as well as a metal blocking effect of phytic acid and other chelating agents, it can be used to prevent tartar.
  • the pyrophosphate may be at least one selected from the group consisting of Na 4 P 2 O 7 , K 4 P 2 O 7 , Na 2 H 2 P 2 O 7 , and K 2 H 2 P 2 O 7 , more preferably K 2 H 2 P 2 O 7 , Na 2 H 2 P 2 O 7 , or a combination thereof, but is not limited thereto.
  • the tooth whitening composition may further comprise a pH adjusting agent.
  • the pH adjusting agent is to improve the long-term storage stability of the tooth whitening composition, it can further improve the storage stability imparted to the composition by the phytic acid.
  • the content of the pH adjusting agent may be 1 to 10% by weight based on the total weight of the tooth whitening composition.
  • the pH regulator is dibasic sodium phosphate, tribasic sodium phosphate, sodium carbonate, sodium bicarbonate, sodium hydroxide, potassium hydroxide, potassium carbonate, ammonium hydroxide, triethanolamine, tris (hydroxymethyl) aminomethane, citric acid, and sodium citrate It may be one or more selected from the group consisting of, preferably sodium bicarbonate, sodium citrate, or a combination thereof, but is not limited thereto.
  • the tooth whitening agent composition may further include an adhesive polymer.
  • the tacky polymer may be coated on the tooth surface to form a film or to formulate the tooth whitening agent in a gel form.
  • the content of the adhesive polymer may be 5 to 80% by weight, preferably 5 to 60% by weight based on the total weight of the tooth whitening agent composition.
  • the viscosity of the whitening component layer may be excessively low, so that applicability may be lowered during the procedure, and when the content of the adhesive polymer is greater than 80% by weight, the viscosity may be excessively increased to reduce workability.
  • the adhesive polymer may be at least one selected from the group consisting of hydroxyethyl cellulose, hydroxypropyl methyl cellulose, polyacrylic acid, polyvinyl alcohol, polyvinylpyrrolidone, carboxymethyl cellulose, carboxyethyl cellulose, and carboxypropyl cellulose, Preferably polyvinylpyrrolidone.
  • the K value of the polyvinylpyrrolidone may be 12 to 120, preferably 80 to 100, more preferably 90 may be.
  • the K value is a value proportional to the molecular weight (polymerization degree), and as the molecular weight increases, the viscosity increases and the K value also increases. K values are described in the US Pharmacopoeia, and physicochemical properties can be found in the US Pharmacopeia and Handbook of Pharmaceutical Excipients.
  • the adhesiveness may be low, causing inconvenience in use. If the K value is more than 120, the peroxide that is a whitening functional active ingredient may not be released smoothly.
  • the weight average molecular weight (Mw) of the adhesive polymer may be 100,000 to 4,000,000, preferably 100,000 to 2,000,000. If the molecular weight of the pressure-sensitive adhesive polymer is less than 100,000 it is difficult to reach a viscosity suitable for coating at a typical amount of use, and if it is more than 4,000,000, the viscosity is high, even at low concentration, it is difficult to apply.
  • the tooth whitening composition may further include a surfactant, the content of the surfactant may be 1 to 10% by weight of the surfactant based on the total weight of the tooth whitening composition. If the content of the surfactant is less than 1% by weight, the flexibility may be reduced to cause a foreign body when used, and if the content is more than 10% by weight, the stability of the tooth whitening agent composition may be lowered.
  • the surfactant may be at least one selected from the group consisting of polyethylene glycol, propylene glycol, glycerin, triethyl citrate, and polysorbate, preferably polyethylene glycol or glycerin, and more preferably glycerin. It is not limited to this.
  • the tooth whitening composition may further include additives such as dental caries suppressor, gum disease improving agent, sweetening agent, hypersensitivity preventing agent, flavoring agent, etc. in addition to the above components.
  • the caries suppressor may be sodium fluoride, calcium fluoride, sodium monofluorophosphate, and the like
  • the gum disease improving agent may include bamboo salt, tocopherol acetate, vitamin D, allantoin chlorohydroxyaluminum, triclosan, xylitol, calcium glycerol phosphate, aminocaproic acid, Monofluorophosphate, and the like
  • the sweetener may be sorbitol, mannitol, aspartame, stevioside, saccharin, and the like
  • the hypersensitivity preventive agent is potassium nitrate, tin fluoride, sodium monofluorophosphate, fluorine chloride, sodium silicate, calcium hydroxide
  • the fragrance may be menthol, peppermint oil, L-menthol, cinnamon acid, or the like.
  • a solvent for dissolving the components may be a mixed solvent of one or more volatile organic solvents and water selected from the group consisting of methanol, ethanol, and butanol, preferably ethanol and water of 1: 1 to 10 Mixed solvents mixed in volume ratios can be used.
  • a gel type tooth whitening composition was prepared by dissolving hydrogen peroxide, phytic acid, sodium bicarbonate, sodium citrate, acidic sodium pyrophosphate, and glycerin in a mixed solvent consisting of distilled water and ethanol, followed by addition of polyvinylpyrrolidone and stirring for at least 1 hour. It was.
  • a gel type tooth whitening composition was prepared in the same manner as in the above example.
  • a gel type tooth whitening composition was prepared in the same manner as in the above example, except that sodium stenate was used instead of phytic acid.
  • a gel type tooth whitening composition was prepared in the same manner as in the above example.
  • a gel type tooth whitening composition was prepared in the same manner as in the above example.
  • composition of the tooth whitening agent composition prepared in Examples and Comparative Examples is shown in Table 1 below. Unless otherwise stated, the units of the numerical values stated are in weight percent.
  • the tooth whitening agent composition prepared in Examples 1, 2, and Comparative Examples 1 to 3 was filled in a 15 ml syringe, and firstly sealed using parafilm, and secondly sealed using pouches. Sealing is complete tooth whitening composition was stored in a constant temperature and humidity (high temperature, 40 °C) was measured periodically for a change in pH for 12 weeks, the results are shown in FIG.
  • the pH whitening composition (Examples 1 and 2) containing a certain amount of phytic acid was found to have excellent pH stability because of less pH change than Comparative Examples 1 to 3 that do not include it.
  • the tooth whitening agent composition prepared in Examples 1, 2, and Comparative Examples 1 to 3 was filled in a 15 ml syringe, and firstly sealed using parafilm, and secondly sealed using pouches. Sealing completed tooth whitening composition was stored in a constant temperature and humidity (high temperature, 40 °C) was measured the change in the residual amount of hydrogen peroxide periodically for 12 weeks, the results are shown in FIG.
  • the tooth whitening agent composition containing a certain amount of phytic acid (Examples 1 and 2) compared to Comparative Examples 1 to 3 that do not include this amount of hydrogen peroxide less hydrogen peroxide is a whitening functional active ingredient contained in the composition
  • the stability was found to be excellent.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Oral & Maxillofacial Surgery (AREA)
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Abstract

Selon un mode de réalisation, la présente invention concerne une composition de blanchiment des dents comprenant un peroxyde à titre de principe actif, la composition de blanchiment des dents comprenant de 0,1 à 10 % en poids d'acide phytique ou d'un sel de celui-ci, sur la base du poids total de la composition de blanchiment des dents.
PCT/KR2016/015357 2016-01-04 2016-12-28 Composition de blanchiment des dents ayant une stabilité améliorée WO2017119660A1 (fr)

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Application Number Priority Date Filing Date Title
TW106100130A TWI682784B (zh) 2016-01-04 2017-01-04 穩定性提高的牙齒美白劑組合物

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KR1020160000402A KR101831259B1 (ko) 2016-01-04 2016-01-04 안정성이 향상된 치아 미백제 조성물
KR10-2016-0000402 2016-01-04

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114773668A (zh) * 2022-03-18 2022-07-22 上海工程技术大学 一种废弃pbt再生为可降解pbat聚合物及其制备和应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101924106B1 (ko) 2017-06-27 2018-11-30 주식회사 엘지화학 장식 부재 및 이의 제조방법
CN112877152B (zh) * 2021-02-06 2022-05-06 濮阳宏业环保技术研究院有限公司 一种包衣过碳酸钠材料及其制备方法和应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060171907A1 (en) * 1996-11-21 2006-08-03 The Procter & Gamble Company Oral care compositions providing enhanced whitening and stain prevention
KR101154935B1 (ko) * 2005-05-12 2012-06-13 주식회사 엘지생활건강 액정상의 치아 미백제
CN103142324A (zh) * 2013-02-21 2013-06-12 沃康生技股份有限公司 牙齿套模及其牙齿美白方法
JP2013542171A (ja) * 2010-04-21 2013-11-21 ディスカス デンタル，エルエルシー 同時に歯をクリーニング及びホワイトニングする方法
KR20140104530A (ko) * 2013-02-18 2014-08-29 오스템임플란트 주식회사 치아 미백 조성물
JP2015101566A (ja) * 2013-11-26 2015-06-04 花王株式会社 歯牙美白剤

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060171907A1 (en) * 1996-11-21 2006-08-03 The Procter & Gamble Company Oral care compositions providing enhanced whitening and stain prevention
KR101154935B1 (ko) * 2005-05-12 2012-06-13 주식회사 엘지생활건강 액정상의 치아 미백제
JP2013542171A (ja) * 2010-04-21 2013-11-21 ディスカス デンタル，エルエルシー 同時に歯をクリーニング及びホワイトニングする方法
KR20140104530A (ko) * 2013-02-18 2014-08-29 오스템임플란트 주식회사 치아 미백 조성물
CN103142324A (zh) * 2013-02-21 2013-06-12 沃康生技股份有限公司 牙齿套模及其牙齿美白方法
JP2015101566A (ja) * 2013-11-26 2015-06-04 花王株式会社 歯牙美白剤

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114773668A (zh) * 2022-03-18 2022-07-22 上海工程技术大学 一种废弃pbt再生为可降解pbat聚合物及其制备和应用

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TWI682784B (zh) 2020-01-21
KR101831259B1 (ko) 2018-02-23
TW201725030A (zh) 2017-07-16

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