WO2014049382A3 - Production de fermentation d'éthylènediamine par un micro-organisme recombinant - Google Patents

Production de fermentation d'éthylènediamine par un micro-organisme recombinant Download PDF

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Publication number
WO2014049382A3
WO2014049382A3 PCT/IB2012/002218 IB2012002218W WO2014049382A3 WO 2014049382 A3 WO2014049382 A3 WO 2014049382A3 IB 2012002218 W IB2012002218 W IB 2012002218W WO 2014049382 A3 WO2014049382 A3 WO 2014049382A3
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WO
WIPO (PCT)
Prior art keywords
ethylenediamine
fermentative production
recombinant microorganism
microorganism
fermentative
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PCT/IB2012/002218
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English (en)
Other versions
WO2014049382A2 (fr
Inventor
Guillaume Letellier
Laurence Dumon-Seignovert
Rainer Figge
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Metabolic Explorer
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Application filed by Metabolic Explorer filed Critical Metabolic Explorer
Priority to PCT/IB2012/002218 priority Critical patent/WO2014049382A2/fr
Publication of WO2014049382A2 publication Critical patent/WO2014049382A2/fr
Publication of WO2014049382A3 publication Critical patent/WO2014049382A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1014—Hydroxymethyl-, formyl-transferases (2.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/03—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with oxygen as acceptor (1.2.3)
    • C12Y102/03001—Aldehyde oxidase (1.2.3.1), i.e. retinal oxidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y201/00—Transferases transferring one-carbon groups (2.1)
    • C12Y201/02—Hydroxymethyl-, formyl- and related transferases (2.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01001—Amino-acid N-acetyltransferase (2.3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01081—N-Acyl-D-amino-acid deacylase (3.5.1.81)

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne un procédé pour la production de fermentation d'éthylènediamine comprenant la culture d'un micro-organisme dans un milieu de culture approprié comprenant une source simple de carbone et d'azote, le micro-organisme comprenant une voie métabolique pour la conversion de la sérine en éthylènediamine.
PCT/IB2012/002218 2012-09-26 2012-09-26 Production de fermentation d'éthylènediamine par un micro-organisme recombinant WO2014049382A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/IB2012/002218 WO2014049382A2 (fr) 2012-09-26 2012-09-26 Production de fermentation d'éthylènediamine par un micro-organisme recombinant

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2012/002218 WO2014049382A2 (fr) 2012-09-26 2012-09-26 Production de fermentation d'éthylènediamine par un micro-organisme recombinant

Publications (2)

Publication Number Publication Date
WO2014049382A2 WO2014049382A2 (fr) 2014-04-03
WO2014049382A3 true WO2014049382A3 (fr) 2015-03-26

Family

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PCT/IB2012/002218 WO2014049382A2 (fr) 2012-09-26 2012-09-26 Production de fermentation d'éthylènediamine par un micro-organisme recombinant

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WO (1) WO2014049382A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10711289B2 (en) 2014-12-23 2020-07-14 Genomatica, Inc. Method of producing and processing diamines from an engineered microorganism
EP3561066B1 (fr) * 2016-12-21 2024-02-07 Fertinagro Biotech, S.L. Procédé d'obtention de polyamines à partir d'une matière protéique
US20210252421A1 (en) 2018-07-10 2021-08-19 Givaudan Sa Improvements in or relating to organic compounds
US11384369B2 (en) 2019-02-15 2022-07-12 Braskem S.A. Microorganisms and methods for the production of glycolic acid and glycine via reverse glyoxylate shunt
JP7463388B2 (ja) 2019-02-20 2024-04-08 ブラスケム エス．エー． ペントース糖およびヘキソース糖のための分解経路
US12006526B2 (en) 2019-02-20 2024-06-11 Braskem S.A. Microorganisms and methods for the production of oxygenated compounds from hexoses

Citations (5)

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Publication number Priority date Publication date Assignee Title
US2760979A (en) * 1952-12-06 1956-08-28 Wacker Chemie Gmbh Process for manufacturing ethylenediamine hydrochloride
WO2007144018A1 (fr) * 2006-06-12 2007-12-21 Metabolic Explorer Production d'éthanolamine par fermentation
DE102007060705A1 (de) * 2007-12-17 2009-06-18 Evonik Degussa Gmbh ω-Aminocarbonsäuren oder ihre Lactame, herstellende, rekombinante Zellen
WO2009113855A2 (fr) * 2008-03-11 2009-09-17 Dsm Ip Assets B.V. Préparation de l’acide 6-aminocaproïque à partir d’acide α-cétopimélique
WO2011031147A1 (fr) * 2009-09-11 2011-03-17 Dsm Ip Assets B.V. Préparation d'un composé comprenant un groupe amine à partir d'un alpha-cétoacide

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TW313589B (fr) 1991-12-12 1997-08-21 Wacker Chemie Gmbh
JP4066543B2 (ja) 1998-01-12 2008-03-26 味の素株式会社 発酵法によるｌ−セリンの製造法
JP3614746B2 (ja) 2000-03-01 2005-01-26 松下電器産業株式会社 半導体レーザ装置および光ピックアップ装置
JP2006517796A (ja) 2003-02-18 2006-08-03 メタボリック エクスプローラー 代謝経路の生成または改変を可能とする進化した微生物の生産方法
FR2862068B1 (fr) 2003-11-06 2007-10-12 Metabolic Explorer Sa Souches de microorganismes optimisees pour des voies de biosyntheses consommatrices de nadph
FR2864967B1 (fr) 2004-01-12 2006-05-19 Metabolic Explorer Sa Microorganisme evolue pour la production de 1,2-propanediol
WO2005111202A1 (fr) 2004-05-12 2005-11-24 Metabolic Explorer Enzyme recombinee avec sensibilite de retroaction modifiee
CN101374940A (zh) 2005-02-07 2009-02-25 代谢探索者公司 包含表达低γ-消除活性的酶的微生物
WO2006082252A2 (fr) 2005-02-07 2006-08-10 Metabolic Explorer Procede destine a la production enzymatique d'alpha-cetobutyrate
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JP5172697B2 (ja) 2006-01-04 2013-03-27 メタボリック エクスプローラー 硫酸透過酵素の発現が増強された微生物を用いてメチオニンおよびその前駆体ホモセリンまたはスクシニルホモセリンを製造するための方法
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Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2760979A (en) * 1952-12-06 1956-08-28 Wacker Chemie Gmbh Process for manufacturing ethylenediamine hydrochloride
WO2007144018A1 (fr) * 2006-06-12 2007-12-21 Metabolic Explorer Production d'éthanolamine par fermentation
DE102007060705A1 (de) * 2007-12-17 2009-06-18 Evonik Degussa Gmbh ω-Aminocarbonsäuren oder ihre Lactame, herstellende, rekombinante Zellen
WO2009113855A2 (fr) * 2008-03-11 2009-09-17 Dsm Ip Assets B.V. Préparation de l’acide 6-aminocaproïque à partir d’acide α-cétopimélique
WO2011031147A1 (fr) * 2009-09-11 2011-03-17 Dsm Ip Assets B.V. Préparation d'un composé comprenant un groupe amine à partir d'un alpha-cétoacide

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Title
ELLER, K., HENKES, E., ROSSBACHER, R. AND HÖKE, H.: "Amines, aliphatic", ULLMANN'S ENCYCLOPEDIA OF INDUSTRIAL CHEMISTRY, 15 June 2000 (2000-06-15), pages 677 - 679, XP002697174, DOI: 10.1002/14356007.a02_001 *

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