WO2014023096A1

WO2014023096A1 - Composition capable of regulating human flora and immune function

Info

Publication number: WO2014023096A1
Application number: PCT/CN2013/072131
Authority: WO
Inventors: 肖天存; 李丽; 张鹏飞
Original assignee: 广州博能生物科技有限公司
Priority date: 2012-08-06
Filing date: 2013-03-04
Publication date: 2014-02-13
Also published as: CN102813113B; CN102813113A

Abstract

Disclosed are a composition capable of regulating a human flora and an immune function and a preparation method of the composition. The composition comprises one of dried vegetable and fruit plant powder or water extract of the vegetable and fruit, fried dried coarse grain powder or the water extract of the coarse grain, fruit juice or vegetable juice together with natural active polysaccharide, propolis, and the like. The composition is capable of regulating the imbalance of the human flora and reinforcing the human immune function.

Description

A composition capable of regulating human flora and immune function

Technical field

The present invention relates to a health care product, and in particular to a method for preparing a composition capable of regulating a human flora and an immune function. Background technique

Immunity is the body's own defense mechanism. It is the body that recognizes and destroys any foreign bodies (viruses, bacteria, etc.) that invade. It treats aging, disease, injury, death, degeneration of self-cells, and recognizes and processes mutant cells and virus-infected cells in vivo. Ability. Modern immunology believes that immunity is the physiological response of the human body to recognize and eliminate "dissidents."

There are many reasons for the reduction of immunity, such as: 1. Intense competition, high pressure for work and study; 2. Fast pace of life and work, nervousness; 3. Changes in diet; 4. Partial eclipse, unbalanced diet; Lack of exercise and so on. In recent years, people in the office, sitting in front of the computer for too long, not paying attention to exercise, the incidence of digestive diseases is increasing, leading to constipation, stomach ulcers, stomach acid, and even obesity. The most direct manifestation of low immunity is easy. sick. Because of frequent illness, the body's consumption is aggravated, so there are generally physical weakness, malnutrition, and sore mouth; easy constipation, stomach acidity, mental dysfunction, fatigue, loss of appetite, sleep disorders, etc., illness, injection, and medication It is commonplace. It takes a long time to recover each time you get sick, and it often recurs. In the long run, it will lead to physical and mental dysplasia, and it is easy to induce major diseases. The underlying cause is low immunity or impaired immunity. When the body's immune function is dysfunctional, or the immune system is not perfect, the gastrointestinal or digestive tract flora changes; scientific experiments and clinical findings, harmful bacteria (such as Wells, etc.) in the human body outweigh the beneficial bacteria (such as bifid Bacillus, etc.) cause disorders in the intestinal flora, causing constipation, diarrhea and low immunity. Intestinal diseases and immunity The two lower diseases are intertwined, causing intestinal dysfunction and failing to function normally, resulting in many complications such as low immunity, intestinal cancer, breast cancer, diabetes, hypertension, and hyperlipidemia. The intestinal disease is very harmful and involves a wide population. It is one of the fierce killers in modern diseases today.

Immunity is closely related to the population of human flora. In addition to mental factors, human immunity is closely related to the body's intake of various substances in the body. It is generally believed that the substances that enhance immunity are as follows: 1. Protein, protein is the basic element that constitutes human cells, and is also the main component of white blood cells and antibodies; if the body is seriously deficient in protein, it will reduce the number of lymphocytes. , causing serious decline in immune function, so eat more high-protein foods, such as: fresh meat, chicken, duck, fish, eggs, milk and dairy products, rich animal protein, containing globulin can help you improve immunity . 2. Vitamin A Vitamin A is related to the integrity of cells. It can help cells fight against oxidation. If the body lacks vitamin A, it will reduce the volume of thymus and spleen, and the relative cell viability will decrease, so it will take enough vitamins. A, can improve the vitality of immune cells and increase the number of immune cells. 3. Vitamin C Vitamin C has the function of promoting the immune system, and increases the ability of white blood cells to phagocytose bacteria, as well as the ability to enhance the thymus and lymphocytes, help the body increase the resistance content and increase the interferon content in the blood. It is an effective antioxidant. It is resistant to destructive molecules and is one of the vitamins that enhance immunity. Vegetables and fruits rich in vitamin C (eg apple, lemon, orange, etc.) are good sources of food for improving immunity. IV. Vitamin E Vitamin E As a free radical, the nemesis can also promote antibody production. From the point of view of anti-virus, it has anti-oxidation effect and enhances the function of immune cells. Generally, foods such as beans, wheat germ, fruits and vegetables, vegetable oil, and stone fruits are more common. Many levels of vitamin E, however, due to changes in modern people's eating habits, the diet is not balanced, so the amount of vitamin E that can be taken from food is very low.

Therefore, for digestive tract diseases, it is necessary to improve the immunity and regulate the gastrointestinal flora, balance the diet, and strengthen the exercise. In the digestive tract disease, in addition to the medical treatment for the cause, supplement Nutrition, improving immunity, changing the body flora, regulating and restoring digestion and absorption are effective ways. There are already many health products for the digestive tract, but more emphasis is placed on on-site absorption and protein and other nutrients, while neglecting balanced nutrition such as vitamins (especially rare vitamins such as vitamins U, K), mineral digestion, dietary fiber Composite synergy. Summary of the invention

In order to overcome the deficiencies of the prior art, the object of the present invention is to provide a composition capable of regulating human flora and immune function, which can be processed into tablets or oral liquids for foods or beverages, to improve immunity and change. The human flora can prevent or treat digestive tract diseases, protect the gastrointestinal environment, prevent obesity, reduce acne, and promote and maintain health.

The technical solution adopted by the present invention to achieve the above object is as follows:

A composition capable of regulating human flora and immune function, comprising the following components in parts by weight: a) vegetable or vegetable dry powder or water extract 1-100 parts

b) Natural active polysaccharide 1-20 parts

c) Propolis 1-20 parts

d) Vitamin C 0-10 parts.

In a preferred embodiment, the composition for regulating human flora and immune function of the present invention comprises the following components in parts by weight.

a) dried fruit or water extract of fruits and vegetables, 50-90 parts

b) Natural active polysaccharides 1-10 parts

c) Propolis 1-10 parts

d) Vitamin C 0-10 parts.

In the present invention, the vegetable and fruit water extract and the natural active polysaccharide are respectively extracted by the following steps: 1) Select raw materials: Choose fresh raw materials for fruits and vegetables;

2) Raw material processing: Wash the above selected raw materials to remove impurities, cut into silk or block;

3) Extraction: Add water after treatment, water is 5-30 times of raw material, Soxhlet extraction or ultrasonic extraction 2-3 times, each extract is filtered, and the filtrate is combined, wherein each extraction time is 1-3 hours. The temperature is controlled at room temperature -100. C;

4) Concentration: The combined filtrate is concentrated under reduced pressure to 1/3-1/2 of the original filtrate volume;

5) Drying: Spray drying or heating to static drying for 5-40 seconds, save for use.

The dried fruit and vegetable powder is a powder of 20-80 μηι which is directly pulverized by a ball mill after washing and dehydrating fresh fruits and vegetables, wherein the rotation speed of the barrel of the ball mill is 18-38 r/min. The drying method can be naturally air-dried or high-temperature drying or freeze-drying. The method is a conventional method which can be grasped by those skilled in the art, and will not be described in detail herein; in order to facilitate subsequent processing into tablets, capsules, sprays, etc. Different preparations.

The preferred vegetable or vegetable plant in the present invention is one or more of vegetables or/and melons and fruits; wherein the vegetables are roots or/and leaves of cabbage, cabbage, mustard, aquatic vegetables, radishes , one or more of celery, asparagus, pepper, etc., wherein the cabbage is selected from the group consisting of pakchoi, cabbage, Chinese cabbage, seaweed, spinach, rape, broccoli, celery, red cabbage Or two or more; the cabbage is selected from one or more of broccoli, broccoli, kale, broccoli, broccoli, etc.; mustard is leaf mustard, stem mustard (head dish), root mustard (kohlrabi) One or two or more, aquatic vegetables, and radishes. The melon fruit is one or a mixture of two or more of apple, pear, orange, watermelon, blueberry, tomato, eggplant, raspberry, papaya, etc., and the present invention is not limited to the above.

A composition capable of regulating human flora and immune function, comprising the following components in parts by weight: a) fried whole grain dry powder or coarse grain water extract 1-100 parts

b) 1-20 parts of natural active polysaccharide c) Propolis 1-20 parts

d) Vitamin C 0-10 parts.

The coarse grain extract described in the present invention is obtained by extracting a concentrate by the following steps:

1) Select raw materials: coarse grains select the raw materials with full particles;

3) Extraction: Add water after treatment, water is 5-30 times of raw material, Soxhlet extraction or ultrasonic extraction 2-3 times, each extract is filtered, and the filtrate is combined, wherein each extraction time is 1-3 hours. The temperature is controlled at 60-100. C;

5) Drying: Spray drying for 5-40 seconds, keep it for use.

The coarse grain described in the present invention is one or more of corn, millet, purple rice, sorghum, oat, buckwheat, wheat bran, soybean, green bean, red bean, mung bean, sweet potato, etc., but is not limited to the above After the coarse grains are dried, the powder of 20-80 μ ηι is directly pulverized by a ball mill, wherein the rotation speed of the ball mill cylinder is 18-38 r/min. The drying method can be carried out by natural air drying or high temperature drying or freeze drying. The method is a conventional method which can be grasped by those skilled in the art and will not be described in detail herein.

A composition capable of regulating human flora and immune function, comprising the following components in parts by weight: a) juice or / and vegetable juice 1-100 parts

b) Natural active polysaccharide 1-20 parts

c) Propolis 1-20 parts

d) Vitamin C 0-10 parts.

In the above aspect, the fruit juice is fresh juice of one or both of apple, orange, pear, blueberry, strawberry, and tomato.

The natural active polysaccharide of the present invention is obtained by extracting a concentrate by the following steps: 1) Select raw materials: Astragalus membranaceus chooses raw materials that are free of insects and mildews and meet Chinese Pharmacopoeia standards;

5) Drying: Spray drying for 5-40 seconds, storage, stand-by.

Based on the above scheme, the composition for regulating human flora and immune function of the present invention further comprises 0-50 parts of edible algae in parts by weight, and the edible algae are seaweed, asparagus, and wakame. , one or more of Mani, kelp, or more.

The natural active polysaccharide mentioned in the present invention is a polysaccharide substance capable of improving immunity; preferably from Astragalus polysaccharide, Jujube polysaccharide, bamboo leaf polysaccharide, Gynostemma, Cordyceps polysaccharide, black bean crude polysaccharide, fig polysaccharide, monkey One or more of the polysaccharides of Pleurotus ostreatus, Chinese kiwifruit polysaccharide, Atractylodes polysaccharide, Rehmannia polysaccharide, Lycium barbarum polysaccharide, Spirulina polysaccharide, Eucommia polysaccharide, and Ligustrum lucidum polysaccharide. Natural active polysaccharides have activated cells, inhibit aging, enhance immune function, prevent diseases, promote disease healing, regulate human physiology, anti-tumor, anti-radiation, anti-oxidation, anti-hypoxia, anti-allergy, anti-inflammatory, hypolipidemic, lower blood Viscosity, hypoglycemic effect

Vitamin C promotes the biosynthesis of collagen, facilitates faster healing of tissue wounds, promotes the metabolism of tyrosine and tryptophan in amino acids, prolongs the life of the body, improves the utilization of iron, calcium and folic acid, and improves fats and Lipids, especially cholesterol metabolism, prevent cardiovascular disease, promote the growth of teeth and bones, prevent gum bleeding, and enhance the body's ability to resist stress and immunity to the external environment. The invention adopts the flavonoid water extract and the propolis and the vitamin C to cooperate with each other to make the antibacterial and the immune enhancement effect To improve and improve, add the dried fruit/water extract or the dried fruit powder/or water extract or juice to the formula to improve the human flora and immunity, and to help the body's balanced diet.

The invention has the beneficial effects that: the composition of the invention can regulate the imbalance of the human flora and enhance the immune function of the human body, has the functions of mediating the stomach, increasing gastrointestinal motility, aeration, and protecting the gastric membrane, and has the functions of hangover and protecting the digestive system. Better effect. The product containing the composition of the present invention can prevent or treat oral ulcers, and has certain auxiliary effects on gum bleeding, bad breath or stomach acid and stomach pain. The invention has the advantages of simple and convenient raw materials, can greatly improve the bioavailability of the material, and can harmoniously distribute and combine the material components to exert the best effect. It can effectively regulate human flora and immune function and create good conditions for human health.

The present invention will be further described in detail below in conjunction with specific embodiments. detailed description

Scheme 1: The composition for regulating human flora and immune function, comprising the following components in parts by weight:

a) Vegetable or vegetable dry powder or water extract 1-100 parts

b) Astragalus polysaccharide 1-20 parts

c) Propolis 1-20 parts

d) Vitamin C 0-10 parts.

Among them, Examples 1-6 were prepared according to the formulation of Scheme 1, and the specific formulation choices of Examples 1-6 are shown in Table 1:

Table 1

Component Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Group of cauliflower dried broccoli dried broccoli dried spinach extract spinach dry powder Chinese cabbage dried a) powder 1 part powder 80 parts powder 100 parts 80 parts 80 100 parts of powder b) 20 parts 1 part 20 parts 20 parts 10 parts 20 parts 酉 c c) 1 part 20 parts 10 parts 20 parts 10 parts 10 parts square d) 0 5 parts 10 parts 5 parts 5 parts 5 parts application example 1

1.8 g of any of the compositions of Examples 1-3 or 5-6 was added, 0.2 g of microcrystalline cellulose was added, and the mixture was mixed and pressed into tablets, and sugars and flavors were appropriately added for the purpose of improving the taste. Investigate 30 cases of oral ulcers due to low immunity, 10 males and 20 females. The patient took this product on the second day of oral ulcers, and healed 28 times every day for 3 days, up to 90%. Healed after five days.

Application example 2

10 g of the composition of Example 4 was added, 5 g of white sugar was added, and the mixture was uniformly mixed to prepare a beverage. Drink once a day. 20 cases of constipation patients were examined, 10 males and 10 females. The patients used this product after constipation, and healed 17 times every day for 3 days, reaching 85%, and all of them healed after five days.

Scheme 2: A composition capable of regulating human flora and immune function, comprising the following components in parts by weight:

a) Fried whole grain dry powder or coarse grain water extract 1-100 parts

b) Cordyceps polysaccharide 1-20 parts

c) Propolis 1-20 parts

d) Vitamin C 0-10 parts.

Among them, the examples 7-12 are prepared according to the formula of the second embodiment, and the specific formula selection of the examples 7-12 is shown in the table.

2:

Table 2

Component Example 7 Example 8 Example 9 Example 10 Example 11 Example 12 Group of cooked soybean dry cooked soybean dry cooked soybean dry millet extract cooked millet dry oatmeal dry powder a) powder 1 part powder 80 parts powder 100 parts 80 parts of powder 80 parts 100 parts b) 20 parts 1 part 20 parts 20 parts 10 parts 20 parts 酉 c) 1 part 20 parts 10 parts 20 parts 10 parts 10 parts square d) 0 5 parts 10 parts 5 parts 5 parts 5 parts Application Example 3

10 g of any of the compositions of Examples 7-9 or 11-12 was added, and white sugar and water were added to prepare a paste. Investigating 30 patients with susceptibility to cold, 10 males and 20 females, these people are prone to colds, the frequency of colds is about once a month, insist on taking the products of the invention, twice a day, the number of people who have a cold within 3 More than half of the 14 people did not have a cold during the three months.

Application example 2

10 g of the composition of Example 10 was added, 5 g of white sugar was added, and the mixture was uniformly mixed to prepare a beverage. 30 patients with gastric acid were enrolled, 10 males and 20 females. They insisted on taking the products of the invention twice a day, and the number of people who recovered after 7 days was 18.

Scheme 3: A composition capable of modulating human flora and immune function, comprising the following components in parts by weight:

a) Juice or / and vegetable juice 1-100 servings

b) jujube polysaccharide 1-20 parts

c) Propolis 1-20 parts

d) Vitamin C 0-10 parts.

Among them, Examples 13-18 were prepared according to the formulation of Scheme 2, and the specific formulation choices of Examples 13-18 are shown in Table 2:

Table 2

Component Example 13 Example 14 Example 15 Example 16 Example 17 Example 18 Freshly squeezed apple freshly squeezed apple freshly squeezed apple apple juice + spinach juice + freshly squeezed strawberry a) juice 1 part juice 80 parts Juice 100 parts of vegetable juice 80 parts of tomato juice 80 parts of juice 100 parts b) 20 parts 1 part 20 parts 20 parts 10 parts 20 parts 酉 c c) 1 part 20 parts 10 parts 20 parts 10 parts 10 parts square d) 0 5 parts 10 parts 5 parts 5 parts 5 parts application examples

20 ml of the composition of Examples 13-18 was separately added to the syrup to prepare a 50 ml beverage, and added to the beverage mass of 1%. Tea polyphenols. Investigating 30 patients with susceptibility to cold, 10 males and 20 females, these people are prone to colds, the frequency of colds is about 1 month each time, insist on taking the products of the invention, three times a day, the number of people who have a cold within three Of the 12 people, 60% did not have a cold during the three months.

Claims

Claim

A composition capable of regulating a human flora and an immune function, characterized in that it comprises the following components in parts by weight

a) Fruit and vegetable dry powder or vegetable and fruit water extract 1-100 parts

b) Natural active polysaccharide 1-20 parts

c) Propolis 1-20 parts

d) Vitamin C 0-10 parts.

2. The composition for regulating human flora and immune function according to claim 1, characterized in that it comprises the following components in parts by weight

a) Fruit and vegetable dry powder or vegetable and fruit water extract 50-90

b) Natural active polysaccharides 1-10 parts

c) Propolis 1-10 parts

d) Vitamin C 0-10 parts.

The composition for regulating human flora and immune function according to claim 1 or 2, wherein the vegetable and fruit water extract is obtained by the following steps:

1) Select raw materials: Choose fresh raw materials for fruits and vegetables;

3) Extraction: Add water after treatment, water is 5-30 times of raw material, Soxhlet extraction or ultrasonic extraction 2-3 times, each extract is filtered, and the filtrate is combined, wherein each extraction time is 1-3 hours. , the temperature is controlled at 60-100 ° C;

5) Drying: Spray drying for 5-40 seconds, keep it for use.

4. The composition capable of regulating human flora and immune function according to claim 3, wherein: the ultrasonic wave has a frequency of 20-100 kHz during ultrasonic extraction.

The composition capable of regulating human flora and immune function according to claim 1 or 2, wherein: the natural active polysaccharide is Astragalus polysaccharide, Jujube polysaccharide, bamboo leaf polysaccharide, Gynostemma, Cordyceps One or more of polysaccharide, black bean crude polysaccharide, fig polysaccharide, Hericium erinaceus polysaccharide, Chinese kiwifruit polysaccharide, Atractylodes polysaccharide, Rehmannia polysaccharide, Lycium barbarum polysaccharide, Spirulina polysaccharide, Eucommia polysaccharide, and Ligustrum lucidum polysaccharide.

The composition for regulating human flora and immune function according to claim 1 or 2, wherein: the vegetable and vegetable dry powder is a 20-80μηι which is directly pulverized by a ball mill after washing the vegetable and fruit raw materials, dehydrating and drying. The powder, wherein the ball mill cylinder has a rotational speed of 18-38 r/min.

The composition for regulating human flora and immune function according to claim 6, wherein: the vegetable or vegetable plant is a vegetable or/and a melon; wherein the vegetable is a cabbage, a cabbage, a mustard, Mixed with one or more of aquatic vegetables, radish roots and/or leaves, celery, asparagus, and peppers, apples, pears, oranges, watermelons, blueberries, tomatoes, eggplants, strawberries, papayas One or two or more kinds are mixed.

The composition capable of regulating human flora and immune function according to claim 1 or 2, further comprising 0-50 parts of edible algae in parts by weight, the edible algae being seaweed and dragon One or a mixture of two or more of sauerkraut, wakame, manicilla, and kelp.

a) Fried whole grain dry powder or coarse grain water extract 1-100 parts

b) Natural active polysaccharide 1-20 parts

c) Propolis 1-20 parts

d) Vitamin C 0-10 parts.

10. The composition for regulating human flora and immune function according to claim 9, characterized in that The crude food extract is obtained by extracting the concentrated liquid by the following steps

5) Drying: Spray drying for 5-40 seconds, keep it for use.

11. The composition capable of regulating human flora and immune function according to claim 10, wherein: the coarse grains are corn, millet, purple rice, sorghum, oat, buckwheat, wheat bran, soybean, green bean, red One or more of beans, mung beans, and sweet potatoes are mixed.

The composition capable of regulating human flora and immune function according to any one of claims 9 to 11, characterized in that it further comprises 0-50 parts of edible algae in parts by weight, wherein the edible algae is One or a mixture of two kinds of seaweed, asparagus, wakame, manicilla, and kelp.

a) Fruit juice or / and vegetable juice 1-100 servings

b) Natural active polysaccharide 1-20 parts

c) Propolis 1-20 parts

d) Vitamin C 0-10 parts.

The composition for regulating human flora and immune function according to claim 13, wherein the juice is freshly squeezed from one or two of apple, orange, pear, blueberry, strawberry, and tomato. juice.