CN106962900A - A kind of instant porridge for recovering menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance and preparation method thereof - Google Patents
A kind of instant porridge for recovering menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance and preparation method thereof Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a kind of instant porridge for recovering menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance and preparation method thereof, the formula is：4 ~ 6 parts of black fungus, 4 ~ 6 parts of the root of kudzu vine, 4 ~ 6 parts of lotus rhizome, 4 ~ 6 parts of Poria cocos, 2 ~ 3 parts of ganoderma lucidum, 2 ~ 3 parts of dandelion, 2 ~ 3 parts of grifola frondosus, 2 ~ 3 parts of Hericium erinaceus, 2 ~ 3 parts of Cordyceps militaris, 2 ~ 3 parts of Agricus blazei, 30 ~ 40 parts of wheat bran, 70 ~ 80 parts of corn, 30 ~ 40 parts of black fungus crude fibre.The instant porridge controls the balance of gut flora by Dietary frequency and then reaches the purpose of alleviation irregular menstruation.
Description
Technical field
The invention belongs to food technology field, and in particular to a kind of fast food of recovery menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance
Congee and preparation method thereof.
Background technology
With the quickening pace of modern life, and social environment pollution, nervous rhythm of life, excessive operating pressure,
Lacking sports etc. can all cause body to be in sub-health state.Women inferior health can trigger many illnesss, especially gynaecology
The disease of aspect, menstrual period are incongruous, are that women falls ill a kind of more gynecological diseases, then menstrual period amount is few for mild symptoms, rises block, existing
Black, underbelly hurt like hell, heavy then too early menopause, disease increases, and crosses presenility., will be to female if do not cured in time
Property causes great damage.It need to start with for menstrual period uncomfortable patient from the habits and customs kept, avoid too tired and stay up late as far as possible
To pay special attention to warming work Deng, female menstrual period, it is to avoid body, which catches cold, allows pelvic blood vessels to shrink, cause menstrual flow reduce and
Amenorrhoea.In addition, can also be improved for menstrual period uncomfortable patient with dietotherapy, grown by eating the higher food of iron-holder more
Mend, the nutrition that body lacks can be supplemented in time, condition is effectively improved.If serious, also need to take related Western medicine or in
Medicine is treated.But prolonged administration of drugs is very big to the injury that women is brought.Do not have a kind of extraordinary method at present
To improve the symptom that female menstrual period is uncomfortable.
There is substantial amounts of symbiosis flora in normal human, these bacteriums are largely colonized in the enteron aisle of people, and quantity exceedes
1000000000000000, equivalent to 10 times of human body cell sum, its microbial gene quantity is about 3,000,000, about mankind's base
Because of more than 100 times of group gene dosage.The gene of such magnanimity can help microorganism to adapt to changeable environment, at the same form with
The inseparable mutualistic symbiosis relation of human body.The metabolin that these bacteriums produce in vegetative activity can enter the blood of people,
Influence the health of people.Wherein, beneficial bacterium can produce anti-inflammatory, analgesia, oxidation resistant material, can be with synthetic vitamin, amino
The nutritional ingredients such as acid, there is nourishing and protective effect to human body；Harmful bacteria can then produce neurotoxin, carcinogen and dissociate anti-
Original, into blood after can cause various chronic diseases, and the gut flora of structural imbalance is probably then induce chronic disease important
Factor.
The regulation for gut flora mainly has at present：External source adds probiotics method and complementary diets fibre method, wherein, benefit
Raw bacterium is a class by improving Host Strains group composition so that the active microorganism of beneficial effect is played, however, probiotics will play
Effect must reach enough active bacteria quantity, and the activity problems of probiotics also limit the extensive use of probiotics；In addition, intestines
Road flora belongs to a big ecosystem, is difficult to produce shadow to the ecological balance of gut flora merely by the addition of probiotics
Ring, although moreover, the addition of probiotics may on it is some individual produce influence, effect it is repeatable and bad；Pass through
Although the regulation tool that complementary diets fiber is balanced to gut flora has certain effect, the time needed for working is longer, generally
Need the time more than a year.
In addition, according to relevant report, hyperlipidemia, cardiovascular and cerebrovascular diseases, tumour, osteoporosis, autoimmune disease are all
It is relevant with intestinal bacilli illness.But do not find relevant report of the gut flora on alleviation menstrual period are uncomfortable also at present, at this stage
Still lack fast and effectively method for the regulation that gut flora is balanced, in particular how recover the enteron aisle of menstrual period uncomfortable patient
The balance of flora.
The content of the invention
For above prior art, the present invention passes through experimental study, finds menstrual period uncomfortable one kind for belonging to intestines source property disease,
Caused by being the chronic inflammation caused by enteric flora disturbance, the menstrual period intestinal microflora of uncomfortable patient is markedly different from health
Group, therefore " balance and then prevention, the auxiliary treatment or treatment menstrual period of gut flora are controlled by nutritional intervention for this proposition is a kind of
It is uncomfortable " inventive concept.On the premise of such a inventive concept, technical scheme is specific as follows：
The first aspect of the invention, propose it is a kind of recover menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance composition, its by
The raw material of following parts by weight is made：
4~6 parts of black fungus, 4~6 parts of the root of kudzu vine, 4~6 parts of lotus rhizome, 4~6 parts of Poria cocos, 2~3 parts of ganoderma lucidum, dandelion 2~3
Part, 2~3 parts of grifola frondosus, 2~3 parts of Hericium erinaceus, 2~3 parts of Cordyceps militaris, 2~3 parts of Agricus blazei, 30~40 parts of wheat bran, corn 70~
80 parts, 30~40 parts of black fungus crude fibre.
Further, it is described recover menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance composition, its by following parts by weight original
Material is made：
5 parts of black fungus, 5 parts of the root of kudzu vine, 5 parts of lotus rhizome, 5 parts of Poria cocos, 2.5 parts of ganoderma lucidum, 2.5 parts of dandelion, 2.5 parts of grifola frondosus,
2.5 parts of Hericium erinaceus, 2.5 parts of Cordyceps militaris, 2.5 parts of Agricus blazei, 35 parts of wheat bran, 75 parts of corn, 35 parts of black fungus crude fibre.
The second aspect of the invention, proposes a kind of preparation for the composition for recovering menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance
Method, comprises the following steps：
(1) preparation of Ultramicro-powder：Raw material will be obtained except other coarse-fibred raw material dehydrations of black fungus and then through ultramicro grinding
Ultramicro-powder；
(2) black fungus is coarse-fibred prepares：Black fungus is crushed, water-bath is extracted, filtering means dehydration collects bacteria residue, and bacteria residue is dried
It is 5-10% to do to water content, produces black fungus crude fibre；
(3) raw material mixes powder：The Ultramicro-powder of raw material and black fungus crude fibre are mixed according to the weight ratio of setting,
Then the water of 8~12% total raw material quality is added, is mixed；
(4) it is expanded：Raw material after mixing is subjected to expanded sterilization, that is, obtains the recovery menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing flora and puts down
The composition of weighing apparatus.
The third aspect of the invention, proposes that a kind of combinations of the above thing is preparing recovery menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing flora
Application in the food of balance or in prevention, auxiliary treatment or treatment menstrual period uncomfortable food is prepared.
The fourth aspect of the invention, proposes a kind of food for recovering menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance, the food
Prepared by above-mentioned composition or use combinations of the above thing to be prepared for main active.
Use of the fifth aspect of the invention there is provided combinations of the above thing and/or food in regulation microbial population of animal intestinal tract
On the way.
A technical scheme in above-mentioned technical proposal has the advantages that：
(1) for menstrual period uncomfortable alleviation, the present invention proposes a kind of composition, and said composition controls intestines by Dietary frequency
The balance of road flora and then the purpose for reaching alleviation irregular menstruation.
(2) preparation method of the composition of the recovery menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance is simple, easy to operate.
(3) black fungus crude fibre, the root of kudzu vine and the lotus rhizome in the present invention are for recovering the flat of menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing flora
Scale has significant effect.
Brief description of the drawings
The Figure of description for constituting the part of the present invention is used for providing a further understanding of the present invention, and of the invention shows
Meaning property embodiment and its illustrate be used for explain the present invention, do not constitute inappropriate limitation of the present invention.
Fig. 1 is before and after disease group volunteer Dietary frequency and the PCA analysis charts of health group volunteer's intestinal microflora.
Fig. 2 is that the menstrual period menstrual cycle fluctuating range of uncomfortable Intestinal Mucosal Injury in Patients Undergoing flora patients before and after intervention compares.
Fig. 3 is the figure of menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing flora patients before and after intervention menstrual cycle relative standard's difference data.
Embodiment
It is noted that described further below is all exemplary, it is intended to provide further instruction to the present invention.Unless another
Indicate, all technologies used herein and scientific terminology are with usual with general technical staff of the technical field of the invention
The identical meanings of understanding.
It should be noted that term used herein above is merely to describe embodiment, and be not intended to restricted root
According to the illustrative embodiments of the present invention.As used herein, unless the context clearly indicates otherwise, otherwise singulative
It is also intended to include plural form, additionally, it should be understood that, when in this manual using term "comprising" and/or " bag
Include " when, it indicates existing characteristics, step, operation and/or combinations thereof.
Term is explained：
OTU(operational taxonomic unit)：Be in phylogenetics or population genetic study, in order to
Analysis is convenient for, the same mark artificially set to some taxon (strain, genus and species, packet etc.).It is to be understood that one
The information of number such as strain, Pseudomonas in sample sequencing result, it is necessary to which categorizing operation is carried out to sequence., will by categorizing operation
Sequence is classified as many groups according to mutual similitude point, and a group is exactly an OUT.Can be according to different similarity water
It is flat, all sequences are carried out with OUT divisions, generally carries out the OUT under 97% similarity level to give birth to letter analysis.
As described in background technology, in the prior art for prevention, auxiliary treatment or treatment menstrual period uncomfortable group
Compound or method come with some shortcomings, the present invention " by nutritional intervention control gut flora balance so as to effectively prevention, it is auxiliary
Help treatment or treatment menstrual period uncomfortable " under such a inventive concept, the first aspect of the invention proposes a kind of to recover menstrual period not
The composition of Intestinal Mucosal Injury in Patients Undergoing colony balance is adjusted, it is made up of the raw material of following parts by weight：
4~6 parts of black fungus, 4~6 parts of the root of kudzu vine, 4~6 parts of lotus rhizome, 4~6 parts of Poria cocos, 2~3 parts of ganoderma lucidum, dandelion 2~3
Part, 2~3 parts of grifola frondosus, 2~3 parts of Hericium erinaceus, 2~3 parts of Cordyceps militaris, 2~3 parts of Agricus blazei, 30~40 parts of wheat bran, corn 70~
80 parts, 30~40 parts of black fungus crude fibre.
The characteristics of said composition is：Based on black fungus crude fibre, wheat bran, corn, black fungus, the root of kudzu vine, lotus rhizome, Poria cocos,
Ganoderma lucidum, dandelion, grifola frondosus, Hericium erinaceus, Cordyceps militaris, Agricus blazei auxiliary black fungus crude fibre, wheat bran, corn play effect.Through
Overtesting finds that black fungus crude fibre serves key effect in regulation gut flora balance, provides and fills for the beneficial bacterium of enteron aisle
The nutrient of foot is so as to promote beneficial microorganism to grow, in addition, black fungus crude fibre has good retention ability, this is also to help
There is the one side of higher degradation efficiency in beneficial microbe, next to that the root of kudzu vine of auxiliary, lotus rhizome, Poria cocos, dandelion etc.,
The growth of the harmful bacteria in gut flora can be suppressed, while also having the effect of anti-inflammatory；It is finally the ash with centralizing function
The raw materials such as flower, Hericium erinaceus are set, are capable of the immune system of direct intervention body.In the experimentation of the present invention, pass through black fungus
Coarse-fibred addition can adjust the content of polysaccharide in composition, it is to avoid cross the intake of polysaccharide, and crude fibre is that human body is difficult
With the composition of digestion, enteral moisture can be kept, and absorbs remaining cholesterol, and is excluded external.Moreover, human hair of the present invention
Now the black fungus crude fibre coordinates with other raw materials and is adapted to menstrual period uncomfortable edible for patients, can promote the growth of beneficial bacteria of intestinal tract,
So as to the balance for the gut flora for recovering menstrual period uncomfortable patient.The black fungus is replaced with after other crude fibres, found
Similar effect can not be played, but significantly reduces the effect of the balance of the gut flora of this recovery menstrual period uncomfortable patient,
This is that have relation with crude fibre species.Separate sources and the crude fibre of heterogeneity have different physiological function or played not
With the physiological function of degree, this is due to caused by whether its structure occurs degraded and be easily degraded by microorganisms.It can be seen that,
Black fungus crude fibre is that present invention screening obtains a kind of effective crucial crude fibre species for recovering menstrual period uncomfortable intestinal microflora.
From the point of view of the effect of menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance is recovered, it is excellent that the present inventor carries out screening to above-mentioned formula
Change, obtain the very good composite formula of one group of effect, as described below：It is made up of the raw material of following parts by weight：
5 parts of black fungus, 5 parts of the root of kudzu vine, 5 parts of lotus rhizome, 5 parts of Poria cocos, 2.5 parts of ganoderma lucidum, 2.5 parts of dandelion, 2.5 parts of grifola frondosus,
2.5 parts of Hericium erinaceus, 2.5 parts of Cordyceps militaris, 2.5 parts of Agricus blazei, 3.5 parts of wheat bran, 75 parts of corn, 35 parts of black fungus crude fibre.
From the point of view of the effect of menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance is recovered, the second aspect of the invention, according to the above
Formula, propose it is a kind of recover menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance composition preparation method, the preparation method include with
Lower step：
(1) preparation of Ultramicro-powder：Raw material will be obtained except other coarse-fibred raw material dehydrations of black fungus and then through ultramicro grinding
Ultramicro-powder；
(2) black fungus is coarse-fibred prepares：Black fungus is crushed, water-bath is extracted, filtering means dehydration collects bacteria residue, and bacteria residue is dried
It is 5-10% to do to water content, produces black fungus crude fibre；
(3) raw material mixes powder：The Ultramicro-powder of raw material and black fungus crude fibre are mixed according to the weight ratio of setting,
Then the water of 8~12% total raw material quality is added, is mixed；
(4) it is expanded：Raw material after mixing is subjected to expanded sterilization, that is, obtains the recovery menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing flora and puts down
The composition of weighing apparatus.
Further operation after step (4), including step (5), crush, dry and pack：
Raw material after expanded is crushed to 15~25 mesh, is packed after drying and dehydrating to less than 5%.
Step (1) and the order of (2) can be exchanged.
In step (1), in some preferred technical schemes of the present invention, the preparation of Ultramicro-powder is comprised the following steps that：
By black fungus, the root of kudzu vine, lotus rhizome, Poria cocos, ganoderma lucidum, dandelion, grifola frondosus, Hericium erinaceus, Cordyceps militaris, Agricus blazei, wheat bran,
Maize raw material is dehydrated to 5-10% through microwave drying；Then more than ultramicro grinding to 300 mesh；Sealing preserve, it is standby.
Above-mentioned raw materials are added in the form of Ultramicro-powder, and the active ingredient in raw material is just discharged before body is entered,
Into after body, soluble component dissolves rapidly, and the low composition of solubility is and tight also because ultra-micro powder has larger absorption affinity
Tightly it is bonded on gastrointestinal mucosa, the residence time is long in vivo, so as to improve the bioavilability of raw material.
In step (2), in order that the effective fiber component content obtained in black fungus crude fibre is larger, in some of the present invention
It is preferred that technical scheme in propose a kind of coarse-fibred preparation method of black fungus, comprise the following steps：Black fungus is smashed, plus
Flooding, extracting condition is：Solid-liquid ratio (mass ratio of black fungus and water) is 1：8~12, extraction temperature is 90~95 DEG C, leaching
The time is carried for 40~60min；Bacteria residue is collected by filtration；Bacteria residue is added water extraction, extracting condition：Solid-liquid ratio (the quality of bacteria residue and water
Ratio) it is 1：8~12, extraction temperature is 90~95 DEG C, and extraction time is 40~60min；Bacteria residue is collected by filtration；Produced after drying
Black fungus crude fibre.
In step (3), from the point of view of the effect of follow-up bulking step, in some preferred technical schemes of the present invention, plus
The quality for entering water is the 10% of total raw material quality.
In step (4), after expanding treatment, the digestibility to raw material can be significantly improved, especially the higher jade of content
Rice and wheat bran, and then raw material resources can be made full use of so that gut flora is more balanced.
Expansion method has many kinds, including frying-expansion technology, extruding and puffing technology, microwave bulking skill in the prior art
Art, low-temperature airflow puffing technology, carbon dioxide puffing technique etc., from the point of view of the effect of regulation gut flora, the present invention is preferably squeezed
Puffing technique is pressed, its conventional equipment is twin-screw Bulking Machine, and the process conditions of expanded sterilization are：Screw speed is 40~80
Turn/min, the temperature of heating region is followed successively by：80~85 DEG C, 90~95 DEG C and 120~130 DEG C.
The third aspect of the invention, proposes that a kind of above-mentioned composition recovers menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing flora in preparation and put down
Application in the food of weighing apparatus or in prevention, auxiliary treatment or treatment menstrual period uncomfortable food is prepared.Art used in herein
Language " food " should do the understanding of broad sense, and it can make any form that can be eaten.For example, the food in the present invention is including general
Logical food and Special food, Special food of the present invention include health food and special medicine purposes formula food；And it is common
It is to be adapted to proprietary food for food is with respect to Special food.
In described application, in order to alleviate, menstrual period are uncomfortable, medicine or food that it can also be uncomfortable with other treatment menstrual period
Product are used cooperatively.
In order to overcome the shortcomings of prevention in the prior art, auxiliary treatment or treatment menstrual period uncomfortable middle medicine or food, this hair
The 4th bright aspect is there is provided a kind of food for recovering menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance, and the food is by combinations thereof
It is that thing is prepared or use what combinations of the above thing prepared for main active.
The present invention, which can be prepared above-mentioned composition, turns into the ordinary food types such as biscuit, instant porridge, beverage.Such as fast food
The preparation of congee：Boiling water reconstitutes above-mentioned composition powder and can obtain instant porridge.
The composition and the instant porridge that is prepared by said composition of the present invention is by promoting the growth of beneficial bacterium, suppressing harmful
The propagation of bacterium, and combine anti-inflammatory, the synergy of righting, can prevent harmful bacteria produce neurotoxin, carcinogen and
Free antigen enters blood, so as to quickly recover the ecological balance of menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing flora.
Based on combination of the above thing and food, the fifth aspect of the invention is being adjusted there is provided combinations of the above thing and/or food
Save the purposes in microbial population of animal intestinal tract.
It should be noted that the signified animal species of term " animal " are not particularly limited used in herein, should
Animal can be any animal with enteron aisle organ, preferably mammal, more preferably rabbit, rat, mouse, people, optimal to choose.
In order that technical scheme can clearly be understood by obtaining those skilled in the art, below with reference to tool
The embodiment of body describes technical scheme in detail with comparative example.
Embodiment 1
A kind of composition for recovering menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance and preparation method thereof, as described below：
1st, raw material：
Black fungus, the root of kudzu vine, lotus rhizome, Poria cocos, ganoderma lucidum, dandelion, grifola frondosus, Hericium erinaceus, Cordyceps militaris, Agricus blazei, wheat bran, jade
Rice.
2nd, pretreatment of raw material：
All raw materials are dehydrated to 5-10% through microwave dryer；It is crushed to more than 300 mesh through ultra micro equipment；Sealing is protected
Deposit, it is standby.
3rd, black fungus is coarse-fibred prepares：
Black fungus powder is some, the pure water of 10 times of black fungus powder quality, 95 DEG C of water-baths 1 hour；1000 revs/min of centrifugations are de-
Water collects bacteria residue；Bacteria residue is soaked in the pure water of 10 times of bacteria residue quality again, 95 DEG C of water-baths 1 hour；1000 revs/min from
Bacteria residue is collected in heart dehydration；Produce black fungus crude fibre；Sealing preserve, it is standby.
4th, powder is mixed：
Black fungus, the root of kudzu vine, lotus rhizome, Poria cocos, each 5 kilograms；
Ganoderma lucidum, dandelion, grifola frondosus, Hericium erinaceus, Cordyceps militaris, Agricus blazei, each 2.5 kilograms；
Black fungus crude fibre, wheat bran, each 35 kilograms；
75 kilograms of corn.
Above-mentioned all raw materials, are stirred 5 minutes through mixed powder machine；The pure water of total raw material quality 10% is added, is stirred 5 minutes.
5th, it is expanded：
Mixed material is cured through twin-screw Bulking Machine and sterilized；Bulking machine running parameter：60 revs/min, No. 1-3 of screw speed
Heating plate operating temperature is followed successively by 85 DEG C, 95 DEG C and 130 DEG C.
6th, crush, dry with it is filling：
The size-reduced machine of puffing material is crushed to 20 mesh or so, is dehydrated through microwave dryer to water content below 5%, every bag 30
It is gram filling.
Embodiment 2
A kind of composition for recovering menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance and preparation method thereof, as described below：
1st, raw material：
Black fungus, the root of kudzu vine, lotus rhizome, Poria cocos, ganoderma lucidum, dandelion, grifola frondosus, Hericium erinaceus, Cordyceps militaris, Agricus blazei, wheat bran, jade
Rice.
2nd, pretreatment of raw material：
All raw materials are dehydrated to 5-10% through microwave dryer；It is crushed to more than 300 mesh through ultra micro equipment；Sealing is protected
Deposit, it is standby.
3rd, black fungus is coarse-fibred prepares：
Black fungus powder is some, the pure water of 12 times of black fungus powder quality, 90 DEG C of water-baths 1 hour；1000 revs/min of centrifugations are de-
Water collects bacteria residue；Bacteria residue is soaked in the pure water of 12 times of bacteria residue quality again, 90 DEG C of water-baths 1 hour；1000 revs/min from
Bacteria residue is collected in heart dehydration；Produce black fungus crude fibre；Sealing preserve, it is standby.
4th, powder is mixed：
Black fungus, the root of kudzu vine, lotus rhizome, Poria cocos, each 6 kilograms；
Ganoderma lucidum, dandelion, grifola frondosus, Hericium erinaceus, Cordyceps militaris, Agricus blazei, each 3 kilograms；
Black fungus crude fibre, wheat bran, each 40 kilograms；
80 kilograms of corn.
Above-mentioned all raw materials, are stirred 5 minutes through mixed powder machine；The pure water of total raw material quality 12% is added, is stirred 10 minutes.
5th, it is expanded：
Mixed material is cured through twin-screw Bulking Machine and sterilized；Bulking machine running parameter：50 revs/min, No. 1-3 of screw speed
Heating plate operating temperature is followed successively by 80 DEG C, 95 DEG C and 120 DEG C.
6th, crush, dry with it is filling：
The size-reduced machine of puffing material is crushed to 20 mesh or so, is dehydrated through microwave dryer to water content below 5%, every bag 30
It is gram filling.
Embodiment 3
A kind of composition for recovering menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance and preparation method thereof, as described below：
1st, raw material：
Black fungus, the root of kudzu vine, lotus rhizome, Poria cocos, ganoderma lucidum, dandelion, grifola frondosus, Hericium erinaceus, Cordyceps militaris, Agricus blazei, wheat bran, jade
Rice.
2nd, pretreatment of raw material：
All raw materials are dehydrated to 5-10% through microwave dryer；It is crushed to more than 300 mesh through ultra micro equipment；Sealing is protected
Deposit, it is standby.
3rd, black fungus is coarse-fibred prepares：
Black fungus powder is some, the pure water of 8 times of black fungus powder quality, 95 DEG C of water-baths 1 hour；1000 revs/min of centrifugations are de-
Water collects bacteria residue；Bacteria residue is soaked in the pure water of 8 times of bacteria residue quality again, 95 DEG C of water-baths 1 hour；1000 revs/min from
Bacteria residue is collected in heart dehydration；Produce black fungus crude fibre；Sealing preserve, it is standby.
4th, powder is mixed：
Black fungus, the root of kudzu vine, lotus rhizome, Poria cocos, each 4 kilograms；
Ganoderma lucidum, dandelion, grifola frondosus, Hericium erinaceus, Cordyceps militaris, Agricus blazei, each 2 kilograms；
Black fungus crude fibre, wheat bran, each 30 kilograms；
80 kilograms of corn.
Above-mentioned all raw materials, are stirred 10 minutes through mixed powder machine；The pure water of total raw material quality 12% is added, 10 points are stirred
Clock.
5th, it is expanded：
Mixed material is cured through twin-screw Bulking Machine and sterilized；Bulking machine running parameter：50 revs/min, No. 1-3 of screw speed
Heating plate operating temperature is followed successively by 85 DEG C, 95 DEG C and 130 DEG C.
6th, crush, dry with it is filling：
The size-reduced machine of puffing material is crushed to 20 mesh or so, is dehydrated through microwave dryer to water content below 5%, every bag 30
It is gram filling.
Embodiment 4
A kind of instant porridge for recovering menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance, is reconstituted in embodiment 1 using boiling water and obtains group
Compound powder, stirring can obtain instant porridge.
First, the inventors discovered that the intestinal microflora of menstrual period uncomfortable patient is markedly different from healthy group, and it is in view of existing
Have a deficiency that gut flora method is adjusted in technology, thus propose a kind of composition for recovering menstrual period uncomfortable gut flora balance and/
Or instant porridge.Secondly, for the design of the composition and/or instant porridge that recover menstrual period uncomfortable gut flora balance, the present inventor
The basic think of constituted using crude fibre, with antibacterial, anti-inflammatory effect raw material, the raw material with centralizing function as said composition
Road, and raw material is screened and optimized under the thinking；For coarse-fibred species, the preferred mushroom crude fibre of the present inventor,
Because being found in process of the test, mushroom crude fibre recovers to have preferably for the gut flora of such intestines source property Disease
Effect, so when screening crude fibre species, being screened preferably in mushroom crude fibre；And for antibacterial, anti-inflammatory effect raw material
Screening, mainly study the effect of its Synergistic being engaged with crude fibre；For the sieve of the raw material with centralizing function
Choosing, is based on the whole structure investigated on the basis of crude fibre and with antibacterial, anti-inflammatory effect raw material fiting effect.
As a result find, different material combination has significant difference for the adjustment effect of menstrual period uncomfortable gut flora, only with comparative example 1
Exemplified by~4, but it is not limited only to following comparative example.
The raw material of comparative example 1 changes
It is with the difference in embodiment 1：Black fungus, the root of kudzu vine, lotus rhizome are replaced with into agrocybe, nutmeg, coix seed.
Corresponding black fungus crude fibre replaces with agrocybe crude fibre.
Other raw materials and operation are same as Example 1.
The raw material of comparative example 2 changes
It is with the difference in embodiment 1：Black fungus, the root of kudzu vine, lotus rhizome are replaced with into Pleurotus nebrodensis, purple perilla, waxgourd peel.
Corresponding black fungus crude fibre replaces with Pleurotus nebrodensis crude fibre.
Other raw materials and operation are same as Example 1.
The raw material of comparative example 3 changes
It is with the difference in embodiment 1：Black fungus, the root of kudzu vine, lotus rhizome are replaced with into true pleurotus cornucopiae, chrysanthemum, kelp.
Corresponding black fungus crude fibre replaces with true pleurotus cornucopiae crude fibre.
Other raw materials and operation are same as Example 1.
The proportional quantity of comparative example 4 changes
It is with the difference in embodiment 1：
Black fungus, the root of kudzu vine, lotus rhizome, Poria cocos, each 2 kilograms；
Ganoderma lucidum, dandelion, grifola frondosus, Hericium erinaceus, Cordyceps militaris, Agricus blazei, each 2 kilograms；
Black fungus crude fibre, wheat bran, each 20 kilograms；
140 kilograms of corn.
Other operations are same as Example 1.
The menstrual period of experimental example 1 uncomfortable Intestinal Mucosal Injury in Patients Undergoing flora intervention experiment
Research approach
1st, selection menstrual cycle incongruous each 100 of healthy volunteer.
2nd, for menstrual period uncomfortable 100 volunteers, gut flora Dietary frequency is carried out using instant porridge (embodiment 4),
60 grams every time (composition in embodiment 1), boiling water reconstitute it is edible, three times a day, intervention time 21 days.
3rd, the just sample of healthy volunteer, and menstrual cycle uncomfortable volunteer's gut flora patients before and after intervention the (the 1st are collected respectively
It and the 22nd day) just sample；Compare the change of its intestinal microflora.Concrete scheme is as follows：1. just it is put into and adds in advance after sample collection
Have in the screw thread cryopreservation tube of absolute ethyl alcohol, cryopreservation tube sealed membrane is sealed and is put into -80 DEG C of ultra low temperature freezers and preserves.2. use
Incubator transport just sample, and add in case ice bag, it is ensured that just sample is in low temperature environment all the time.3. just sample reaches laboratory
Afterwards, centrifugation removes the absolute ethyl alcohol just in sample, using CTAB methods and coordinates dedicated kit to extract gut flora STb gene.4. make
Enter performing PCR, specific amplification enteric bacteria 16SrDNA V1V2 areas with primer 2 7F+355R, target fragment length is about
328bp；Barcode sequences and upper machine sequencing primer then are added at fragment two ends, and carries out high-flux sequence.5. to lower machine after
Original series carry out Quality Control, delete the sequencing correlated series such as barcode, and cast out the sample of reads lazy weights 300,000,000
This.6. OTU divisions are carried out to the high-quality sample sequence Jing Guo Quality Control and PCA is analyzed.
4th, the menstrual cycle number of days of each six times of every menstrual cycle uncomfortable volunteer's gut flora patients before and after intervention is counted, respectively
The relative standard deviation of 6 menstrual cycle number of days of patients before and after intervention is calculated, situation is fluctuated with the menstrual cycle for assessing patients before and after intervention.
Result of study
As Fig. 1 shows that the intestinal microflora of 100 volunteers of disease group is markedly different from healthy group；And it is dry in meals
Prognosis, the intestinal microflora of disease group volunteer tends to health status substantially.Illustrate the instant porridge regulation enterobacteriaceae of the present invention
The effect of group significantly, can effectively recover the balance of menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing flora.
As Fig. 2 and Fig. 3 data display, disease group volunteer after gut flora restores balance, menstrual cycle number of days
Fluctuation is significantly reduced.Illustrate the instant porridge by adjusting gut flora, can effectively alleviate female menstrual period uncomfortable.
The menstrual period of experimental example 2 uncomfortable Intestinal Mucosal Injury in Patients Undergoing flora intervention experiment
Research approach
1st, menstrual cycle inconsistent volunteer 40 is selected.
2nd, for menstrual period uncomfortable 40 volunteers, routine is used as using the composition powder in 1~comparative example of comparative example 4
Food is eaten, 60 grams every time, boiling water reconstitute it is edible, three times a day, intervention time 21 days.Edible couple of patient code 1~10
Composition in ratio 1, patient code 11~20 eats the composition in comparative example 2, and patient code 21~30 eats comparative example 3
In composition, patient code 31~40 eat comparative example 4 in composition.
3rd, the menstrual cycle number of days of each six times of every menstrual cycle uncomfortable volunteer's gut flora patients before and after intervention is counted, respectively
The relative standard deviation of 6 menstrual cycle number of days of patients before and after intervention is calculated, situation is fluctuated with the menstrual cycle for assessing patients before and after intervention.
Result of study
The menstrual cycle fluctuating range before and after composition powder in menstrual period 1~comparative example of uncomfortable edible for patients comparative example 4
Compare and be shown in Table 1.
1 menstrual cycle of table fluctuating range compares
It can be obtained from above experimental result (table 1), the composition powder eaten in comparative example 1~4 is last, menstrual cycle number of days
Fluctuation is unanimous on the whole.Illustrate that the composition in comparative example 1~4 can not effectively alleviate female menstrual period uncomfortable, meanwhile, this 40 aspirations
The composition powder that person is eaten in comparative example 1~4 is last, and not other side effects are produced, and illustrate that said composition powder can be made
Eaten for general food.
It is hereby achieved that, in the composition for recovering menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance of the invention, each raw material group
It is an organic whole to divide, indispensable.Inventor has found in R＆D process, reduces any one of above-mentioned composition
Raw material components are replaced to the raw material components of the present composition, then composition integrally significantly drops to flora adjustment effect effect
It is low.Therefore, each raw material components are to play recovery menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing flora as an entirety to put down in the present composition
The effect of weighing apparatus, and then uncomfortable auxiliary treatment or treatment are played a part of to menstrual period.In addition, each raw material in the composition of the present invention
Consumption is also very crucial, and inventor is adjusted in process of the test to the consumption of some raw materials in composition, knot
Fruit finds that the composition after adjustment consumption is remarkably decreased to the adjustment effect of menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance.
Above-described embodiment is preferably embodiment, but embodiments of the present invention are not by above-described embodiment of the invention
Limitation, other any Spirit Essences without departing from the present invention and the change made under principle, modification, replacement, combine, simplification,
Equivalent substitute mode is should be, is included within protection scope of the present invention.
Claims (10)
1. it is a kind of recover menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance composition, it is characterized in that, its by following parts by weight raw material
It is made：
4 ~ 6 parts of black fungus, 4 ~ 6 parts of the root of kudzu vine, 4 ~ 6 parts of lotus rhizome, 4 ~ 6 parts of Poria cocos, 2 ~ 3 parts of ganoderma lucidum, 2 ~ 3 parts of dandelion, grifola frondosus 2 ~ 3
Part, 2 ~ 3 parts of Hericium erinaceus, 2 ~ 3 parts of Cordyceps militaris, 2 ~ 3 parts of Agricus blazei, 30 ~ 40 parts of wheat bran, 70 ~ 80 parts of corn, black fungus crude fibre 30
~ 40 parts.
2. composition as claimed in claim 1, it is characterized in that, it is made up of the raw material of following parts by weight：
5 parts of black fungus, 5 parts of the root of kudzu vine, 5 parts of lotus rhizome, 5 parts of Poria cocos, 2.5 parts of ganoderma lucidum, 2.5 parts of dandelion, 2.5 parts of grifola frondosus, hedgehog hydnum
2.5 parts of mushroom, 2.5 parts of Cordyceps militaris, 2.5 parts of Agricus blazei, 35 parts of wheat bran, 75 parts of corn, 35 parts of black fungus crude fibre.
3. the preparation method of the composition of the recovery menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance described in claim 1 or 2, its feature
It is to comprise the following steps：
（1）The preparation of Ultramicro-powder：The super of raw material will be obtained except other coarse-fibred raw material dehydrations of black fungus and then through ultramicro grinding
Micro mist；
（2）Black fungus is coarse-fibred to be prepared：Black fungus is crushed, water-bath extract, filtering means dehydration collect bacteria residue, by bacteria residue dry to
Water content is 5-10%, produces black fungus crude fibre；
（3）Raw material mixes powder：The Ultramicro-powder of raw material and black fungus crude fibre are mixed according to the weight ratio of setting, then
The water of 8 ~ 12% total raw material quality is added, is mixed；
（4）It is expanded：Raw material after mixing is subjected to expanded sterilization, that is, obtains the recovery menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance
Composition.
4. preparation method as claimed in claim 3, it is characterized in that：In step（4）Also include step afterwards（5）, crush, dry
And packaging：Raw material after expanded is crushed to 15 ~ 25 mesh, is packed after drying and dehydrating to less than 5%.
5. preparation method as claimed in claim 3, it is characterized in that：Step（1）In, the preparation of Ultramicro-powder is comprised the following steps that：
It will be dehydrated except other coarse-fibred raw materials of black fungus through microwave drying to 5-10%；Then more than ultramicro grinding to 300 mesh；
Step（2）In, the coarse-fibred preparation method of black fungus comprises the following steps：Black fungus is smashed, add water extraction, extracted
Condition is：Solid-liquid ratio is 1：8 ~ 12, extraction temperature is 90 ~ 95 DEG C, and extraction time is 40 ~ 60min；Bacteria residue is collected by filtration；By bacterium
Slag adds water extraction, extracting condition：Solid-liquid ratio is 1：8 ~ 12, extraction temperature is 90 ~ 95 DEG C, and extraction time is 40 ~ 60min；Filtering
Collect bacteria residue；Black fungus crude fibre is produced after drying.
6. preparation method as claimed in claim 3, it is characterized in that：Step（4）In, the process conditions of expanded sterilization are：Screw rod
Rotating speed is 40 ~ 80 turns/min, and the temperature of heating region is followed successively by：80 ~ 85 DEG C, 90 ~ 95 DEG C and 120 ~ 130 DEG C.
7. composition described in claim 1 or 2 in the food for recovering menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance is prepared or
Prepare the application in prevention, auxiliary treatment or treatment menstrual period uncomfortable food.
8. a kind of food for recovering menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance, it is characterized in that：The food is by claim 1 or 2
It is that described composition is prepared or use the composition described in claim 1 or 2 to be prepared for main active
's.
9. a kind of instant porridge for recovering menstrual period uncomfortable Intestinal Mucosal Injury in Patients Undergoing colony balance, it is characterized in that：The instant porridge is reconstituted using water
Composition described in claim 1 or 2 is prepared.
10. the food in composition and/or claim 8 or 9 described in claim 1 or 2 is in regulation microbial population of animal intestinal tract
Purposes.
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|---|---|---|---|---|
| CN102578554A (en) * | 2011-12-27 | 2012-07-18 | 天津市林业果树研究所 | Edible mushroom instant powder processing method |
| CN102813113A (en) * | 2012-08-06 | 2012-12-12 | 广州博能生物科技有限公司 | Composition capable of regulating human flora and immune function |
| CN106309506A (en) * | 2016-09-23 | 2017-01-11 | 泰安大凡神农制药有限公司 | Probiotic composition with menstruation regulating function and application thereof |
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- 2017-04-12 CN CN201710235493.0A patent/CN106962900A/en active Pending
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| CN102578554A (en) * | 2011-12-27 | 2012-07-18 | 天津市林业果树研究所 | Edible mushroom instant powder processing method |
| CN102813113A (en) * | 2012-08-06 | 2012-12-12 | 广州博能生物科技有限公司 | Composition capable of regulating human flora and immune function |
| CN106309506A (en) * | 2016-09-23 | 2017-01-11 | 泰安大凡神农制药有限公司 | Probiotic composition with menstruation regulating function and application thereof |
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