Classifications

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  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
  • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
  • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
  • A61K31/225—Polycarboxylic acids
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  • A61K31/16—Amides, e.g. hydroxamic acids
  • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
  • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/13—Amines
  • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
  • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
  • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
• • A—HUMAN NECESSITIES
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  • A61K31/275—Nitriles; Isonitriles
• • A—HUMAN NECESSITIES
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  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/275—Nitriles; Isonitriles
  • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
• • A—HUMAN NECESSITIES
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  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/33—Heterocyclic compounds
  • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
  • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
  • A61K31/47—Quinolines; Isoquinolines
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/33—Heterocyclic compounds
  • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
  • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
  • A61K31/47—Quinolines; Isoquinolines
  • A61K31/4704—2-Quinolinones, e.g. carbostyril
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/0012—Galenical forms characterised by the site of application
  • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/20—Pills, tablets, discs, rods
  • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
  • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
  • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/20—Pills, tablets, discs, rods
  • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K39/00—Medicinal preparations containing antigens or antibodies
  • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Definitions

• the invention relates to pharmaceutical compositions for oral use comprising a fixed combination of a first active pharmaceutical ingredient of dimethylfumarate or a pharmaceutically acceptable administration form thereof and a second active pharmaceutical ingredient selected from teriflunomide, fingoiimod and laquinimod or a pharmaceutically acceptable administration form thereof and to the use of such compositions in treating multiple sclerosis.
• dimethylfumarate in combination with teriflunomide or fingoiimod or laquinimod according to this invention allows lowering the dose of dimethylfumarate a nd/or the agent selected from teriflunomide, fingoiimod and laquinimod below levels previously believed to be necessary for efficacy, while achieving better efficacy with comparable adverse effects than seen for the individual agents.
• the combination therapy can also achieve non- inferior efficacy compared to each of the individual agents when given alone at optimally effective dose but will be associated with less adverse effects compared to the individual agents when given alone at an optimally effective dose.
• the combinations according to the present invention may also allow for a reduced dosing frequency
• MS Multiple sclerosis
• CNS central nervous system
• MS relapsing-remitting MS
• SPMS secondary progressive MS
• Some cases of MS follow a continuously progressive pattern without remission phases already from the beginning primary progressive MS, PPMS
• Other cases have periods of acute exacerbations while proceeding along a course of increasing neurological deficits without remissions (progressive-relapsing MS, PRMS).
• the onset of the disease is usually in young adults and it is more common in women. About 2-2.5 million people are living with MS worldwide.
• the treatment of choice for exacerbations is generally high doses of corticosteroids.
• the treatment of the chronic progression of MS aims to target the underlying immune disorder with the goal to reduce the frequency of relapses, to reduce the progression of disability and to preserve brain structure.
• the available treatments are generally based on immunosuppressive and immunomodulatory mechanisms while for some drugs additional direct neuroprotective effects are postulated.
• Treatment success in clinical trials is primarily measured by the reduction in annual relapse rate (ARR) while other commonly used endpoints include time to disability progression as assessed by the Expanded Disability Status Scale (EDSS) or reduction in new brain lesions as measured by brain magnetic resonance imaging (MR] ⁇ .
• ARR annual relapse rate
• EDSS Expanded Disability Status Scale
• MR brain magnetic resonance imaging
• MS is treated with chemotherapeutic agents such as the FDA approved Mitoxantrone (Novantrone) or off- label azathioprine, methotrexate, cladribine and cyclophosphamide.
• chemotherapeutic agents such as the FDA approved Mitoxantrone (Novantrone) or off- label azathioprine, methotrexate, cladribine and cyclophosphamide.
• DMF Dimethylfumarate
• FAE fumaric acid esters
• Form 1 belongs to the class of fumaric acid esters (FAE) and appears to have the most attractive safety profile and good efficacy based on two randomized, double-blind, placebo-controlled, dose-comparison Phase III studies with overall more than 2600 patients (DEFINE study (Gold R. et ai Vietnamese N Engl J Med. 2012 Sep 20;367 ⁇ 12):1098-107) and CONFI RM study (Fox RJ et al., N Engl J Med . 2012 Sep 20;367(12): 1087-97).
• BG-12 dimethylfumarate
• TID three times daily
• GA subcutaneous glatiramer acetate
• dimethylfumarate met the primary endpoint by significantly reducing annualized relapse rate by 44% and 51% for BID and TID, respectively versus placebo. It also met all secondary relapse and MR! endpoints in both dose regimens.
• Dimethylfumarate BID and TID reduced the number of new or newly enlarging T2-hyperintense lesions by 71 and 73%, new Ti-hypo intense lesions by 57 and 65% and the proportion of patients who relapsed by 34 and 45% compared to 54, 41 and 29% for glatiramer acetate, respectively.
• Dimethylfumarate also reduced 12-week confirmed disability progression as measured by EDSS by 21% for BID and 24% for TID at 2 years compared to 7% for placebo and glatiramer acetate.
• the most common adverse effects in the dimethylfumarate groups were flushing and gastrointestinal (Gl) events. There were no malignancies in the dimethylfumarate groups.
• DEFINE which analyzed the efficacy and safety of dimethylfumarate 240 po capsules BID and TID in 1237 patients with RRM showed a significant reduction in the proportion of patients with RRMS who relapsed at 2 yea rs compared with placebo ⁇ primary endpoint, 49% reduction versus placebo for BID and 50% reduction versus placebo for TID), Both doses of dimethylfumarate showed a significant reduction in annualized relapse rate (53% reduction versus placebo for BID and 48% reduction versus placebo for TID ⁇ , in the number of new or newly enlarging T2 hyperintense lesions, in new gadolinium-enhancing (Gd+) lesions, and in the rate of disability progression as measured by the Expanded Disability Severity Scale (EDSS) at 2 years (secondary endpoint) ⁇ Gold R. et ai., N Engl J Med. 2012 Sep 20;367 ⁇ 12):1098-107).
• EDSS Expanded Disability Severity Scal
• teriflunomide (Genzyme) ⁇ (Z)-2-cv3 ⁇ 4no-3-hydroxy-but-2-enoic acid-(4'-trifluoro- methylpheny!-amide) (Formula 2) that, in accordance with this invention, may be used in combination with DMF, also has an excellent safety profile in Phase III trials where data on more than 2.500 patients has already been presented (TEMSO study, O'Connor et al, N Engl J Med. 201;365(14): 1293-303, TENERE study Press release, Sanofi, 20 Dec 2012, TOWER study, Press release, Sanofi, 1 Jun 2012). The most important side effects seen in Phase ill trials were diarrhea, hair thinning and elevation of transaminases.
• TEMSO a randomized, double-blind, placebo-controlled Phase 111 trial of terifiunomide 7 mg and 14 mg p.o. once-daily in 1088 RRMS patients showed that terifiunomide 7 mg and 14 mg significantly reduced annualized relapse rate (ARR) by 31.2% and 31.5% at 2 years compared to placebo (primary endpoint).
• Terifiunomide 7 mg and 14 mg The risk of disability progression was reduced by 24% and 30% for terifiunomide 7 mg and 14 mg, respectively, Terifiunomide also reduced the brain disease activity on a range of magnetic resonance imaging measures including reduction of the burden of disease by 39% and 67% for terifiunomide 7 mg and 14 mg, respectively, compared to placebo, Terifiunomide 7 mg and 14 mg doses were well tolerated, with treatment emergent adverse events including diarrhea, nausea and alanine transferase increases were reported in similar number of patients. No serious opportunistic infections occurred in patients treated with terifiunomide.
• terifiunomide 7 mg and 14mg significantly increased the time to first relapse by 53.7% and 56,5% during the two years of the study compared to 45.6% on placebo, respectively (TEMSO study, O'Connor et ai, N Engl J Med. 201;365(14):1293-303 and Press release, Sanofi-Aventis, 30 Aug 2010 and Press release, Sanofi, 5 Oct 2011).
• TENERE a randomized, open-label Phase III trial in 324 patients with RRMS to assess the effectiveness of 2 doses of terifiunomide 7 mg and 14 mg po tablet once-daily vs interferon-pia showed no statistical superiority between the Rebif and terifiunomide arms (7 mg and 14 mg) on risk of treatment failure, which was defined as the occurrence of a confirmed relapse or permanent treatment discontinuation for any cause, whichever came first.
• the terifiunomide 7 mg dose showed a higher relapse rate (0.410) than the 14 mg daily dose (0.259) and Rebif (0.216).
• TOWER a multi-center, randomized, double-blind, placebo-controlled Phase III trial in 1169 RRMS patients, to eva luate 2 doses of terifiunomide 7 mg and 14 mg p.o. tablet once-daily versus placebo showed that patients receiving terifiunomide 14 mg had a significant reduction of 36.3% in annualized relapse rate and 31.5% reduction in the risk of 12wk sustained accumulation of disability compared to placebo. In the 7 mg group a significant reduction in annualized relapse rate was observed compared to placebo but there was no significant difference observed for the risk of 12wk sustained accumulation of disability.
• the most common types of adverse events reported more frequently in the terifiunomide arms were headache, ALT elevations, hair thinning, diarrhea , nausea and neutropenia (Press release, Sanofi, 1 Jun 2012).
• Teriflunomide was also used in a Phase II combination trial as add-on therapy to IFN where a significant effect on M R! endpoints was observed for 7 mg and 14 mg doses while no significant effect was seen for the reduction in annualized relapse rate (Freedman, Neurology. 2012 Jun 5;78(23 ⁇ :1877-1885).
• Teriflunomide at 7 mg or 14 mg added to glatiramer acetate was more effective than placebo added to in reducing Tl-Gd lesions (Freedman et at. Neurology. 2010;74(9):A293.).
• Teriflunomide selectively and reversibly inhibits dihydro-orotate dehydrogenase (DHOOH), a mitochondrial enzyme required for de novo pyrimidine synthesis.
• DHOOH dihydro-orotate dehydrogenase
• De novo pyrimidine synthesis is required for fast proliferating cells such as activated lymphocytes to meet their needs in DNA, lipid, and sugar metabolism.
• Fingolimod Another drug candidate that may be used in combination with DMF, according to the present invention, is fingolimod (Formula 3).
• Fingolimod is already approved for RRMS in the US, many European countries and Japa n at a dose of 0.5 mg p.o. once daily (Gilenya, Novartis).
• Fingolimod is an oral sphingosine 1-phosphate receptor (S1PR) modulator which blocks lymphocyte egress from secondary lymphoid organs. After uptake, fingolimod is phosphorylated by sphingosine kinase to the active form which can now bind with high affinity to S1PR.
• S1PR oral sphingosine 1-phosphate receptor
• Binding of phosphorylated fingolimod leads to internalization and degradation of the receptor and also to downregulation of S1PR messenger RNA. This results In a decrease of S1PR on the cell surface with consecutive inhibition of lymphocyte egress from lymphoid tissues into the peripheral blood and decreased lymphocyte levels in cerebrospinal fluid (CSF) which finally contributes to reduction of inflammatory events in the central nervous system.
• CSF cerebrospinal fluid
• fingoiimod also has a direct neuroprotective effects through interaction with S1PR on oligodendrocytes, astrocytes, and microglia.
• the 12-months active-comparator Phase ill trial TRANSFORMS which randomized 1292 patients with RRMS and a history of at least one relapse to oral fingoiimod (0.5 or 1.25mg/day) or intramuscular (l.m .) IFIM-b-la (Avanex, 30pg/week) found that 1-year relapse rates with Fingoiimod were 52% (0.5 mg/day) and 38% (1.25 mg/day) lower than with Avonex and that 83% (0. 5 mg/day) and 80% (1.25 mg/day) of patients on fingoiimod remained relapse-free vs. only 69% on Avonex.
• the 24-month double-blind, placebo-controlled FREEDOMS trial studied 1272 patients with EDSS scores of 0-5.5, and at least one relapse in the previous year or at least two relapses in the previous 2 years and fingoiimod doses of 0.5 mg/day and 1.25 mg/day versus placebo.
• Fingoiimod reduced the frequency of MS relapses by 54% and 60%, and the risk of disability progression by 30% and 32% confirmed after 3 months during the 24-months period and 37% and 40% confirmed after 6 months during the 24- months period, respectively, vs. placebo.
• laquinimod A further candidate which may be combined with DMF, in accordance with the present invention, is laquinimod (Formula 4).
• Laquinimod has passed two la rge Phase III studies (ALLEGRO and BRAVO trials with more than 2400 patients with RRMS) and was filed for marketing authorization in the EU in 2012, while a confirmatory Phase III trial (CONCERTO in 1800 RRMS patients) to support the US submission is ongoing (Press releases Teva and Active Biotech and Comi G et al., N Engl J Med. 2012 Mar 15;366(ll):1000-9).
• ALLEGRO the first of the two finished Phase III trials, patients were randomized to receive once-daily oral 0.6 mg laquinimod or matching placebo for 24 months.
• the primary endpoint was the number of confirmed relapses during the 24-months double blind study period while secondary endpoints included confirmed disability progression and changes in MRI.
• the study enrolled 1106 RRMS patients (Press releases Teva and Active Biotech and Comi G et al., N Engl J Med. 2012 Mar 15;366(ll):1000-9).
• Iaquinimod has immunomodulatory properties within the central nervous system and may also have direct neuroprotective effects (reviewed in Giacomini PS, Clin Immunol. 2012 Jan; 142(l):38-43).
• Laquinimod's molecular target is not well-defined, however some studies suggest that it can bind S100A9, a calcium binding protein that influences cell signaling.
• Pre-clinical studies were able to show that laquinimod's effects are in part mediated through decreased Thl and Thl7 responses and an increase in regulatory T cells with reduction of pro-inflammatory cytokines IFN-y and TNFa while promoting production of the anti-inflammatory cytokines IL-4, IL-10 and TGF- ⁇ .
• Iaquinimod seems to be able to interfere with lymphocyte migration into the central nervous system through interaction with specific adhesion molecules.
• BDNF brain derived neurotrophic factor
• One strategy with the potential to increase treatment efficacy is to combine two or more drugs with distinct modes of action, Such combinations have, for example, been generally described in WO 2007/006307 (salts of fumaric acid monoalkylesters with a multitude of other drugs, see pages 20-25) and specifically claimed in WO 2011/100589 ⁇ fumaric acid esters such as dimethylfumarate with either glatiramer acetate or interferon beta).
• the above described experimental combination therapies with teriflunomide are further examples, but they have not resulted in unequivocally positive results.
• This invention is in its broadest aspect is directed toward novel com bination of oral agents to treat multiple sclerosis, i.e. a combination of teriflunomide, fingolimod or laquinimod with dimethylfumarate.
• fingolimod and laquinimod have been selected as powerful partners to be combined with d imethylfumarate due to the partly non-overlapping mechanism of action with dimethylfumarate as well as the generally non-overlapping side-effect profile.
• the two active ingredients contained in the combination formulation may be present in any pharmaceutically acceptable administration form of either of them.
• Such pharmaceutically acceptable administration forms include any pharmaceutically acceptable and therapeutically effective crystalline and non ⁇ crysta lline forms, solvates or hydrates, and in the case of teriflunomide its Z- and E-enolic forms and mixtures thereof and also its prod rug leflunomide.
• a further component of the claimed oral pharmaceutical composition according to the present invention is one or more pharmaceutically acceptable excipients.
• excipient as used in this application is to be understood broadly and encompasses any pharmaceutically acceptable inactive substance that may be present in an oral pharmaceutical administration form, including (but not limited to) fillers, diluents, binders, matrix formers, disintegrants, lubricants, sustained release agents, coating agents and the like.
• This invention also provides a pharmaceutical composition containing dimethylfumarate in combination with teriflunomide or fingolimod or laquinimod as the sole active ingredients, together with one or several pharmaceutically acceptable excipients, which is suitable for once daily administration.
• One preferred embodiment of the invention provides for administering a novel fixed-dose combination for once daily oral use of a first active component which is dimethylfumarate, at a dose that is therapeutically effective when used alone, and of a second active component which is teriflunomide, at a dose that has not shown therapeutic efficacy when used alone. Therefore, according to a preferred aspect of the invention, this pharmaceutical composition contains dimethylfumarate at a dose range of 500 mg to 750 mg and terif!unomide at a dose range of 1 mg to 6 mg.
• Another preferred embodiment of the invention provides for administering a novel fixed-dose combination for once daily oral use of a first active component which is dimethylfumarate, at a dose that is therapeutically effective when used alone, and of a second active component which is fingolimod, at a dose that has not shown therapeutic efficacy when used alone. Therefore, according to a preferred aspect of the invention, this pharmaceutical composition contains dimethylfumarate at a dose range of 500 mg to 750 mg and fingolimod at a dose ra nge of 0.05 mg to 0.45 mg.
• another preferred embodiment of the invention provides for administering a novel fixed-dose combination for once daily oral use of a first active component which is dimethylfumarate, at a dose that is therapeutically effective when used atone, and of a second active component which is laquinimod, at a dose that has not shown therapeutic efficacy when used alone. Therefore, according to a preferred aspect of the invention, this pharmaceutical com position contains dimethylfumarate at a dose range of 500 mg to 750 mg and laquinimod at a dose range of 0,05 mg to 0,25 mg.
• the combination products described herein will show better efficacy (as measured by reduction of annualized relapse rate and/or progression of disability and/or a similarly accepted endpoint) than dimethylfumarate alone.
• the inventive combination products will not show an increase in severe adverse events compared with dimethylfumarate and the individual combination partners alone.
• a further embodiment of the invention provides for administering a novel fixed-dose combination for once daily oral use of a first component which is dimethylfumarate, in a daily dose below the daily doses shown to be therapeutically effective for MS in DEFINE and CONFIRM studies, and of a second active component which is teriflunomide, fingolimod or laquinimod at a dose that has not shown therapeutic efficacy when used alone.
• the combination product according to this preferred aspect of the invention will show a non- inferior efficacy (as measured by reduction of annualized relapse rate and/or progression of disability and/or a similarly accepted endpoint ⁇ compared with each dimethylfumarate and teriflunomide, fingolimod a nd laquinimod, respectively, when used at therapeutically effective doses alone but will be associated with less adverse effects compared to the individual agents when given alone at a respective dose.
• the composition contains dimethylfumarate at a dose range of 125 mg to 500 mg and teriflunomide at a dose range of 1 mg to 6 mg.
• the composition contains dimethylfumarate at a dose range of 125 mg to 500 mg and fingolimod at a dose range of 0.05 mg to 0.45 mg. In yet another preferred aspect of the present invention the composition contains dimethylfumarate at a dose range of 125 mg to 500 mg and laquinimod at a dose ra nge of 0.05 mg to 0.25 mg.
• a further embodiment of the invention provides for administering a novel fixed-dose combination for twice da ily oral use of a first active component which is dimethylfumarate, at a dose that is therapeutically effective when used alone, and of a second active component which is teriflunomide, fingolimod or laquinimod, at an absolute daily dose that has not shown therapeutic efficacy when used alone.
• the combination product will show a significantly better efficacy ⁇ as measured by reduction of annualized relapse rate and/or progression of disability and/or a similarly accepted endpoint ⁇ then dimethylfumarate atone, in addition, this combination will not show a statistically significant increase in severe adverse events compared with dimethylfumarate alone.
• a further embodiment of the invention provides for administering a novel fixed-dose combination for twice daily oral use of a first component which is dimethylfumarate, in a dose below the doses shown to be therapeutically effective in DEFINE and CONFIRM studies, and of a second active component which is teriflunomide, fingolimod or laquinimod at an absolute daily dose that has not shown therapeutic efficacy when used alone.
• This combination product will show a non-inferior efficacy (as measured by reduction of annualized relapse rate and/or progression of disability and/or a similarly accepted endpoint) compared with each dimethylfumarate and teriflunomide, fingolimod and laquinimod, respectively, when used at therapeutically effective doses alone but will be associated with less adverse effects compared to the individual agents when given alone at a respective dose.
• teriflunomide is replaced in ali of the above combinations by its prodrug leflunomide at a bioequivalent dose (as measured by teriflunomide pharmacokinetics),
• This invention is related to a method of treating MS in a human patient in need of such treatment and comprises administering to said patient a combination therapy in a single oral dosage form (e.g. a tablet or capsule) of dimethylfumarate in combination with teriflunomide (or its prodrug leflunomide), fingolimod or laquinimod.
• a single oral dosage form e.g. a tablet or capsule
• the combination formulation is more effective than the single agents alone and/or has reduced side effects and better tolerabiiity than the single agents alone and/or can be given in a reduced frequency.
• dimethylfumarate as well as teriflunomide, fingolimod and laquinimod have each been used individually for the treatment of MS, the agents have not been used in combination for the treatment of MS.
• the inventors have recognized that anadded or synergistic effect of dimethylfumarate, on the one hand, and terifunomide, fingolimod or laquinimod, on the other hand, will most likely be due to the fact that dimethylfumarate and the other three agents have different molecular targets and many non- overlapping modes of action in the pathophysiology of MS.
• Dimethylfumarate acts through depletion of GSH stores and activation of nrf2 which mediates significant neuroprotective properties in addition to its leading imm unomodulatory effects with interference with the Thl/Th2 differentiationwhile no major Immunosuppressive effects have been observed.
• Teriflunomide acting through selective inhibition of dihydro-orotate dehydrogenase (DHODH), fingolimod, acting through downregulation of S1PR on the cell surface, and laquinimod, potentially acting through S100A9, are assumed to have effects on additional aspects of the immune response, such as lymphocyte migration, regulatory T cell responses and antibody production, leading to a potentially more broad inhibitory effect with relevant immu nosuppressive activity.
• DHODH dihydro-orotate dehydrogenase
• fingolimod acting through downregulation of S1PR on the cell surface
• laquinimod potentially acting through S100A9
• the specific spectrum of activities of these respective agents and the selection of optimal doses allows for a particularly advantageous efficacy and side effect profile of the combination.
• a drug such as teriflunomide, fingolimod or laquinimod at a dose that was not shown to have a significant clinical effect when used alone still has a significant additional effect when used in combination with another drug (dlmethylfumaratej at a dose that is effective afone.
• the combination will be associated with a similar or even more benign side effect profile compared to the single drugs.
• combining a drug usually used in a twice daily regime such as dimethylfumarate with a drug usually used in a once daily regime such as teriflunomide, fingolimod or laquinimod may allow creating a once daiiy combination drug with non- infe rior efficacy to both drugs when used alone and, depending on specific side effect profile and dose, no increase in side effects.
• composition according to the present invention is intended for once daily use and consists of component 1) Dimethylfumarate at a dose range of 500 mg to 750 mg and of component 2) Teriflunomide at a dose range of 1 mg to 6 mg and of components 3) (excipients) which are required for the pharmaceutical formulation.
• a particularly preferred combination according to this aspect of the invention wiil contain 625 mg dimethylfumarate and 5 mg teriflunomide.
• Further preferred combinations contain 500 mg dimethylfumarate and 6 mg teriflunomide, 500 mg dimethylfumarate and 5 mg teriflunomide, 500 mg dimethylfumarate and 4 mg teriflunomide, 500 mg dimethylfumarate and 3 mg teriflunomide, 625 mg dimethylfumarate and 4 mg teriflunomide, 625 mg dimethylfumarate and 3 mg teriflunomide, 625 mg dimethylfumarate and 2 mg teriflunomide, and 625 mg dimethylfumarate and 1 mg teriflunomide.
• further preferred embodiments contain 750 mg dimethylfumarate in combination with 1, 2, 3, 4 or 5 mg teriflunomide.
• composition according to the invention is intended for once daily use and consists of component 1) Dimethylfumarate at a dose range of 125 mg to 500 mg and of component 2) Teriflunomide at a dose range of 1 mg to 6 mg and of components 3) (excipients) which are required for the pharmaceutical formulation.
• the composition according to this aspect of the invention is intended for once daily use and consists of component 1) Dimethylfumarate at a dose range of 125 mg to 375 mg and of component 2 ⁇ Teriflunomide at a dose range of 1 mg to 6 mg and of components 3) (excipients) which are required for the pharmaceutical formulation.
• Particularly preferred combinations according to this aspect of the invention contain 375 mg dimethylfumarate in combination with 2, 3, 4, 5 or 6 mg teriflunomide, or 375 mg dimethylfumarate in combination with I, 2, 3, 4 or 5 mg teriflunomide, or 375 mg dimethylfumarate in combination with 5 mg teriflunomide, or 250 mg dimethylfumarate in combination with 2, 3, 4, 5 or 6 mg teriflunomide, or 125 mg dimethylfumarate in combination with 3, 4, 5 or 6 mg teriflunomide.
• a third preferred composition is intended for twice daily use and consists of component 1) Dimethylfumarate at a dose range of 250 mg twice daily to 375 mg twice daily and of component 2) Teriflunomide at a dose range of 0.5 mg twice daily to 3 mg twice daily and of components 3 ⁇ which are required for the pharmaceutical formulation.
• A. particularly preferred combination according to this aspect of the invention will contain 375 mg dimethylfumarate and 2.5 mg teriflunomide.
• Further preferred combinations contain 250 mg dimethylfumarate and 3 mg teriflunomide, 250 mg dimethylfumarate and 2.5 mg teriflunomide, 250 ⁇ mg dimethylfumarate and 2 mg teriflunomide, 250 mg dimethylfumarate and 1,5 mg teriflunomide, 375 mg dimethylfumarate and 2 mg teriflunomide, 375 mg dimethylfumarate and 1.5 mg teriflunomide, 250 mg dimethylfumarate and 1 mg teriflunomide, and 375 mg dimethylfumarate and 0.5 mg teriflunomide. Further preferred embodiments contain 375 mg dimethylfumarate in combination with 0.5» 1, 1.5, 2, or 2.5 mg teriflunomide.
• a fourth composition is intended for twice daily use and consists of component 1 ⁇ Dimethylfumarate at a dose range of 60 mg twice daily to 250 mg twice daily and of component 2) Teriflunomide at a dose range of 0,5 mg twice daily to 3 mg twice daily and of components 3) which are required for the pharmaceutical formulation.
• a particularly preferred combination according to this aspect of the invention will contain 150 mg dimethylfumarate and 2.5 mg teriflunomide.
• Further preferred combinations contain 125 mg dimethylfumarate and 5 mg teriflunomide, 150 mg dimethylfumarate and 3 mg teriflunomide, 125 mg dimethylfumarate and 2.5 mg teriflunomide, 125 mg dimethylfumarate and 2 mg teriflunomide, 125 mg dimethylfumarate and 1.5 mg teriflunomide, 150 mg dimethylfumarate and 2 mg teriflunomide, 150 mg dimethylfumarate and 1.5 mg teriflunomide, 125 mg dimethylfumarate and 1 mg teriflunomide, and 150 mg dimethylfumarate and 0.5 mg teriflunomide. Further preferred embodiments contain 180 mg dimethylfumarate in combination with 0,5, 1, 1.5, 2, or 2.5 mg teriflunomide.
• compositions according to the invention that are intended for once or twice daily use according to the present invention include those wherein Teriflunomide is present in the form of bioequivalent doses (as measured by teriflunomide pharmacokinetics) of its prodrug Leflunomide. Teriflunomide forms from leflunomide via rearrangement and ring opening.
• one preferred composition according to the present invention is intended for once daily use and consists of component 1) Dimethylfumarate at a dose range of 500 mg to 750 mg and of component 2 ⁇ Fingolimod at a dose range of 0,05 mg to 0.045 mg and of components 3) (excipients) which are required for the pharmaceutical formulation,
• a particularly preferred combination according to this aspect of the invention will contain 625 mg dimethylfumarate and 0,4 mg fingolimod.
• Further preferred combinations contain 500 mg dimethylfumarate and 0.4 mg fingolimod, 500 mg dimethylfumarate and 0.3 mg fingolimod, 500 mg dimethylfumarate and 0.2 mg fingolimod, 500 mg dimethylfumarate and 0.1 mg fingolimod, 625 mg dimethylfumarate and 0.3 mg fingolimod, 625 mg dimethylfumarate and 0.2 mg fingolimod, 625 mg dimethylfumarate and 0.1 mg fingolimod, and 625 mg dimethylfumarate and 0.05 mg fingolimod.
• compositions contain 750 mg dimethylfumarate in combination with 0.05, 0,1, 0.2, 0.3, 0.4, 0.45 mg fingolimod.
• Another preferred composition according to the invention is intended for once daily use and consists of component 1) Dimethylfumarate at a dose range of 125 mg to 460 mg and of component 2) Fingoiimod at a dose range of 0.05 mg to 0.45 mg and of components 3) (excipients) which are required for the pharmaceutical formulation.
• the composition according to this aspect of the invention is intended for once daily use and consists of component 1) Dimethylfumarate at a dose range of 125 mg to 375 mg and of component 2) Fingoiimod at a dose range of 0.05 mg to 0.045 mg and of components 3) (excipients) which are required for the pharmaceutical formulation.
• Particularly preferred combinations according to this aspect of the invention contain 375 mg dimethylfumarate in combination with 0.05, 0.1, 0,2, 0.3, 0.4, 0.45 mg fingoiimod, or 250 mg dimethylfumarate in combination with 0.05, 0.1, 0.2, 0.3, 0.4, 0,45 mg fingoiimod, or 125 mg dimethylfumarate in combination with 0.05, 0.1, 0.2, 0.3, 0.4, 0.45 mg fingoiimod.
• compositions intended for twice daily use and consists of component 1) Dimethylfumarate at a dose range of 250 mg twice daily to 375 mg twice daily and of component 2) Fingoiimod at a dose range of 0.025 mg twice daily to 0.2 mg twice daily and of components 3) which are required for the pharmaceutical formulation.
• a particularly preferred combination according to this aspect of the invention will contain 375 mg dimethylfumarate and 0.2 mg fingoiimod.
• Further preferred combinations contain 250 mg dimethylfumarate and 0.1 mg fingoiimod, 250 mg dimethylfumarate and 0.3 mg fingoiimod, 250 mg dimethylfumarate and 0.4 mg fingoiimod, 250 mg dimethylfumarate and 0,45 mg fingoiimod, 375 mg dimethylfumarate and 0.2 mg fingoiimod, 375 mg dimethylfumarate and 0.3 mg fingoiimod. Further preferred embodiments contain 375 mg dimethylfumarate in combination with 0.05, 0.1, 0.2, 0.3, 0,4, 0.45 mg fingoiimod.
• a fourth composition is intended for twice daily use and consists of component 1) Dimethylfumarate at a dose range of 60 mg twice daily to 230 mg twice daily and of component 2) Fingoiimod at a dose range of 0.025 mg twice daily to 0.2 mg twice daily and of components 3) which are required for the pharmaceutical formulation.
• a particularly preferred combination according to this aspect of the invention will contain 150 mg dimethylfumarate and 0.2 mg fingoiimod.
• Further preferred combinations contain 125 mg dimethylfumarate and 0.2 mg fingoiimod, 150 mg dimethylfumarate and 0.3 mg fingoiimod, 125 mg dimethylfumarate and 0.3 mg fingoiimod, 125 mg dimethylfumarate and 0.1 mg fingoiimod, 125 mg dimethylfumarate and 0.05 mg fingoiimod, 150 mg dimethylfumarate and 0.4 mg fingoiimod, 150 mg di methylfumarate and 0.45 mg fingoiimod, 125 mg dimethylfumarate and 0.45 mg fingoiimod. Further preferred embodiments contain 180 mg dimethylfumarate in combination with 0.025 mg twice daily to 0.2 fingoiimod.
• compositions are particularly preferred.
• One preferred composition a ccording to the present invention is intended for once daily use and consists of component 1) Dimethylfumarate at a dose range of 500 mg to 750 mg and of component 2) Laquinimod at a dose range of 0.05 mg to 0.25 mg and of components 3 ⁇ (excipients) which are required for the pharmaceutical formulation.
• a particularly preferred combination according to this aspect of the invention will contain 625 mg dimethylfumarate and 0.25 mg laquinimod.
• Further preferred combinations contain 500 mg dimethylfumarate and 0.25 mg laquinimod, 500 mg dimethylfumarate and 0.2 mg laquinimod, 500 mg dimethylfumarate and 0, 15 mg laquinimod, 500 mg dimethylfumarate and 0.1 mg laquinimod, 625 mg dimethylfumarate and 0.2 mg laquinimod, 625 mg dimethylfumarate and 0.15 mg laquinimod, 625 mg dimethylfumarate and 0.1 mg laquinimod, and 625 mg dimethylfumarate and 0.05 mg laquinimod. Further preferred embodiments contain 750 mg dimethylfumarate in combination with 0.05, 0.1, 0.15, 0.2, and 0,25 mg laquinimod.
• composition according to the invention is intended for once daily use and consists of component 1 ⁇ Dimethylfumarate at a dose range of 125 mg to 460 mg and of component 2) Laquinimod at a dose range of 0.05 mg to 0.25 mg and of components 3) (excipients) which are required for the pharmaceutical formulation.
• the composition according to this aspect of the invention is intended for once daily use and consists of component 1) Dimethylfumarate at a dose range of 125 mg to 375 mg and of com ponent 2 ) Laquinimod at a dose range of 0.05 mg to 0.25 mg and of components 3) (excipients) which are required for the pharmaceutical formulation.
• Particularly preferred combinations according to this aspect of the invention contain 375 mg dimethylfumarate in combination with 0.05, 0.1, 0.15, 0.2, 0.25 laquinimod, or 250 mg dimethylfumarate in combination with with 0.05, 0.1, 0.15, 0.2, 0.25 mg laquinimod, or 125 mg dimethylfumarate in combination with 0.05, 0.1, 0.15, 0.2, 0.25 mg laquinimod.
• compositions intended for twice daily use and consists of component 1) Dimethylfumarate at a dose range of 250 mg twice daily to 375 mg twice daily and of component 2) Laquinimod at a dose range of 0.025 mg twice daily to 0.125 mg twice dairy and of components 3) which a re required for the pharmaceutical formulation.
• a particularly preferred combination according to this aspect of the invention will contain 375 mg dimethylfumarate and 0.125 mg laquinimod.
• Further preferred combinations contain 250 mg dimethylfumarate and 0.125 mg laquinimod, 250 mg dimethylfumarate and 0, 1 mg laq uinimod, 250 mg dimethylfumarate and 0.05 mg laquinimod, 250 mg dimethylfumarate and 0.025 mg laquinimod, 375 mg dimethylfumarate and 0.1 mg laquinimod, 375 mg dimethylfumarate and 0.05 mg laquinimod and 375 mg dimethylfumarate in combination with 0.025 mg laquinimod.
• compositions are intended for twice daily use and consists of component 1) Dimethylfumarate at a dose range of 60 mg twice daily to 230 mg twice daily and of component 2) Laquinimod at a dose range of 0.025 mg twice daily to 0.125 mg twice daily and of components 3) which are required for the pharmaceutical formulation.
• a particularly preferred combination according to this aspect of the invention will contain 150 mg dimethylfumarate and 0.125 mg laquinimod.
• Further preferred combinations contain 125 mg dimethylfumarate and 0.125 mg laquinimod, 125 mg dimethylfumarate and 0.1 mg laquinimod, 125 mg dimethylfumarate and 0.05 mg laquinimod, 125 mg dimethylfumarate and 0.025 mg laquinimod, 150 mg dimethylfumarate and 0.1 mg laquinimod, 150 mg dimethylfumarate and 0.05 mg laquinimod, 150 mg dimethylfumarate and 0.025 mg laquinimod.
• teriflunomide or fingolimod or laquinimod Is used at doses that are below demonstrated therapeutic effectiveness when used alone.
• the therapeutic benefit of the preferred inventive combinations is caused by unexpected additional effects provided by teriflunomlde or fingolimod or laquinimod at doses heretofore thought to be probably ineffective.
• Dimethylfumarate has been demonstrated to induce a disease modifying a nd disease intervening effect as measured on annual relapse rates and progression of disability in patients.
• Most pharmaceutical drugs have S-shaped dose-response curves or bell shaped dose response curves.
• Another pharmacological agent such as teriflunomide or fingolimod or laquinimod would thus be expected to shift the aggregated dose-response curve in a favorable manner and thus be of major clinical and therapeutic utility.
• a further aspect of the present invention is a suitable pharmaceutical formulation for once or twice daily oral administration of the inventive combination of dimethylfumarate and teriflunomide or fingolimod or laquinimod.
• the formulation can be any oral formulation, but is preferably a tablet or peilet formulation, or a capsule formulation, e.g. a gelatin capsule, Tablets, pellets or capsules can be enteric-coated or non- enteric -coated.
• the two active ingredients are present in different portions of the oral formulation that are designed to release the respective active ingredient with different speeds.
• the invention also provides a pharmaceutical composition for oral use against MS that contains dimethylfumarate and teriflunomide or fingolimod or laquinimod as the active ingredients, wherein the dimethylfumarate is contained in a portion of the composition that provides for prolonged release of the active ingredient and the teriflunomide or fingolimod or laquinimod is contained in a portion of the composition that provides for rapid release of the active ingredient.
• the dimethylfumarate is contained in a prolonged release matrix portion of a tablet and the teriflunomide or fingolimod or laquinimod is contained in a coating surrounding the matrix portion, In a particular embodiment, the teriflunomide or fingolimod or laquinimod is contained in an outer enteric coating surrounding the matrix portion of the tablet, which embeds and surrounds the dimethylfumarate. In an alternative embodiment teriflunomide or fingolimod or laquinimod is contained in a separate water-soluble or readily water-disintegratable layer between the core and the outer enteric coating, or as the outermost layer. Suitable tablets according to the invention may contain lactose (e.g.
• tabiettose or macrocrystalline cellulose as a filler, hydroxypropylcellulose or hydro xypropylmethy!cel!ulose as matrix-forming retarding agent and magnesium stearate as a lubricant, and they may be coated, e.g. with a film coat or an enteric coat or a drug-containing layer.
• Useful coating agents include acrylic polymers, e.g. from the Eudragit series, such as Eudragit L30D and cellulose esters such as hypromellose.
• Prolonged or sustained release matrix formulations that are suitable to serve as prolonged release matrix portions of the inventive tablets are disclosed in WO 2010/079222 the disclosure of which is incorporated herein in its entirety.
• Such prolonged release matrix formulations may be provided with an additional fast release coating containing teriflunomide or fingolimod or laquinimod.
• teriflunomide or fingolimod or laquinimod may be added to an enteric coating as provided in many of the examples of WO 2010/079222.
• a coated erosion matrix tablet can be used to formulate the combination of dimethylfumarate and teriflunomide or fingolimod or laquinimod according to the present invention.
• the two active ingredients can also be put into respective controlled release ⁇ CR ⁇ and immediate release (IR) microtablets or pellets, which can then be filled into gelatin capsules or sachets.
• IR immediate release
• dimethylfumarate will again be In a CR microtablet or pellet
• terlflunomide or fingolimod or laquinimod will be in the IR microtablet or pellet.
• the DMF core tablets can also consist of 2 layers, one being a controlled release ⁇ CR) and a second being an immediate release (IR); the table gives a typical composition for a selected distribution of DMF to CR and IR layer; other distributions of DMF are also possible.
• the described 2-layer tablet cores can be coated as the DMF tablets described elsewhere in the patent to yield the combination products.
• Examples 1-3 Clinical trial design to demonstrate the proposed synergistic effects.
• a clinical trial will include multiple sclerosis patients of Remitting-Relapsing type diagnosed on McDonald criteria, with a baseline Expanded Disability Status Scale (EDDS) between 0 and 5 and either at least one relapse within the last 12 months of randomisation and a previous MRI scanning showing lesions consistent with multiple sclerosis or Gd E lesions on MRI scan done within 6 months of randomisation. Excluded will be patients with a relapse within 50 days of randomisation or no stabilization from a previous relapse.
• EDDS Expanded Disability Status Scale
• the trial will be approved by all relevant Competent Agencies as well as all relevant Ethic Committees.
• the trial will be a randomized, double blind, double-dummy, placebo controlled parallel group design testing 3 active treatment arms and a placebo arm:
• 1.1 a combination tablet consisting of SOOmg prolonged release DMF and the instant release 6 mg teriflunomide in a single formulated enteric coated tablet;
• 2.1 a combination tablet consisting of SOOmg prolonged release DMF and the instant release 0.3 mg fingolimod in a single formulated enteric coated tablet;
• the placebo arm 1.4, 2.4 and 3.4 will also document the sensitivity of all 3 active arms 1.1-1.3, 2.1-2.3 and 3.1-3.2.
• Primary endpoints will be based on M RI scans using the number and volume of new GdE lesions on post contrast Tl-weighed sequences as well as the number of T2-weighed enlarged lesions. Secondary endpoints will be the number of relapses monitored monthly and the EDDS that will be assessed at 12 weeks interval from baseline as well as brain atrophy. Safety will be followed closely in particular on differential count of white blood cells, liver enzyme values, gastrointestinal side effects and infections. Laboratory examination will be performed every 4 weeks and general safety as assessed by the reporting of SAE's and AE's and neurological and physical examination.
• Treatment time will be 24 weeks initially for the evaluation of the primary endpoint followed by a blinded 24 week follow up where the active treatment groups will continue their randomized treatment and the patients on placebo will transferred to active treatment with a continued blinded dosing where they will receive an active combination tablet consisting of 500mg DMF in the prolonged release formulation and the instant release of either teriflunomide, fingolimod or laquinimod in an enteric coated tablet.
• the number of patients will be 400 with a 1: 1: 1: 1 randomisation between the groups based on previously reported mean MRI lesions reduction data with DMF treatment and treatment with either teriflunomide, fingolimod or laquinimod, assuming a 20% reduction in the number of new GdE lesions, a power of 80% to detect a treatment effect based on a two- sided 5% significance level.
• All MR! evaluations will be performed centrally by an experienced neuroradiologist.
• An interim analysis is planned after all patients have completed the first 24 weeks compa ring each active arm against placebo and furthermore the combination tablet treatment arm compared to each of the single treatment arms. Analysis will be performed using adaptive design and closed analysis with no adjustment of the significance level.
• Plasma samples for population kinetics will be sampled at baseline, week 4, 8, 12, 24, 36 and 48 of the trial schedule.
• An enteric coated tablet containing an erosion matrix core with a film coat is used to formulate the com bination of dimethylfumarate and teriflunomide (Example 4), dimethylfumarate and fingolimod ( Example 5) and dimethylfumarate and laquinimod (Example 6), respectively, according to the present invention.
• the enteric coated tablet consists of an erosion matrix core hosting the dimethylfumarate covered by a film coating hosting teriflunomide (Example 4), fingolimod (Example 5) and laquinimod (Example 6), respectively, and an outer thin enteric coating.
• the enteric coating rapidly dissolves when reaching the small intestine and releases teriflunomide, fingolimod and iaquinimod, respectively, in the duodenum at weakly alkaline pH values..
• the dimethylfumarate is released in a prolonged manner (controlled release) over several hours,
• composition of the tablet core for a 125 mg DMF strength is shown in the following table (same for all
• Example 4 Example 4, Example 5, arid Example 6).
• 275 mg cores are then coated with 5 wt.-% of an aqueous PVA-solution containing e.g. 5 mg teriflunomide or e.g. 0.3 mg fingolimod or e.g. 0.25 mg Iaquinimod so as to obtain a teriflunomide-or fingolimod- or laqulnimod-containing layer that rapidly dissolves when being contacted with water.
• an aqueous PVA-solution containing e.g. 5 mg teriflunomide or e.g. 0.3 mg fingolimod or e.g. 0.25 mg Iaquinimod so as to obtain a teriflunomide-or fingolimod- or laqulnimod-containing layer that rapidly dissolves when being contacted with water.
• a thin enteric coating is then applied to these coated cores.
• the coating has the following composition:
• the actually applied coat is approximately 2 wt-%.
• Iaquinimod the following combinations are envisaged: varying combinations of a tablet core with prolonged release formulation of DMF containing 60 mg, 125 mg, 150 mg, 250 mg, 375 mg and 500 mg combined with 0.025 mg, 0.05 mg, 0.1 mg, 0.2 mg, 0.25 mg of Iaquinimod embedded in the film coating will apply.
• manufacture and coating steps are carried out by known methods such as, e.g., described in WO 2010/079222, examples 21 and 22.

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