EA201590166A8 - Комбинированная терапия для лечения рассеянного склероза - Google Patents
Комбинированная терапия для лечения рассеянного склерозаInfo
- Publication number
- EA201590166A8 EA201590166A8 EA201590166A EA201590166A EA201590166A8 EA 201590166 A8 EA201590166 A8 EA 201590166A8 EA 201590166 A EA201590166 A EA 201590166A EA 201590166 A EA201590166 A EA 201590166A EA 201590166 A8 EA201590166 A8 EA 201590166A8
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- treatment
- teriflunomide
- fingolimod
- agent selected
- dimethyl fumarate
- Prior art date
Links
- 208000034189 Sclerosis Diseases 0.000 title 1
- 238000002648 combination therapy Methods 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- OSNIIMCBVLBNGS-UHFFFAOYSA-N 1-(1,3-benzodioxol-5-yl)-2-(dimethylamino)propan-1-one Chemical compound CN(C)C(C)C(=O)C1=CC=C2OCOC2=C1 OSNIIMCBVLBNGS-UHFFFAOYSA-N 0.000 abstract 2
- LDCRTTXIJACKKU-ONEGZZNKSA-N dimethyl fumarate Chemical compound COC(=O)\C=C\C(=O)OC LDCRTTXIJACKKU-ONEGZZNKSA-N 0.000 abstract 2
- 229960004419 dimethyl fumarate Drugs 0.000 abstract 2
- 229960000556 fingolimod Drugs 0.000 abstract 2
- KKGQTZUTZRNORY-UHFFFAOYSA-N fingolimod Chemical compound CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1 KKGQTZUTZRNORY-UHFFFAOYSA-N 0.000 abstract 2
- 229960000331 teriflunomide Drugs 0.000 abstract 2
- UTNUDOFZCWSZMS-YFHOEESVSA-N teriflunomide Chemical compound C\C(O)=C(/C#N)C(=O)NC1=CC=C(C(F)(F)F)C=C1 UTNUDOFZCWSZMS-YFHOEESVSA-N 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229960000681 leflunomide Drugs 0.000 abstract 1
- VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12179232.9A EP2692343A1 (en) | 2012-08-03 | 2012-08-03 | Combination therapy for treatment of multiple sclerosis |
| US201261712008P | 2012-10-10 | 2012-10-10 | |
| EP12187939.9A EP2692344A1 (en) | 2012-08-03 | 2012-10-10 | Combination therapy for treatment of Multiple sclerosis |
| PCT/EP2013/066285 WO2014020156A1 (en) | 2012-08-03 | 2013-08-02 | Combination therapy for treatment of multiple sclerosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201590166A1 EA201590166A1 (ru) | 2015-06-30 |
| EA201590166A8 true EA201590166A8 (ru) | 2015-10-30 |
Family
ID=47008405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201590166A EA201590166A8 (ru) | 2012-08-03 | 2013-08-02 | Комбинированная терапия для лечения рассеянного склероза |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20150164849A1 (enExample) |
| EP (4) | EP2692343A1 (enExample) |
| JP (2) | JP2015523407A (enExample) |
| KR (3) | KR20150040338A (enExample) |
| CN (3) | CN104684553A (enExample) |
| AU (3) | AU2013298517A1 (enExample) |
| CA (2) | CA2880742C (enExample) |
| DK (1) | DK2879672T3 (enExample) |
| EA (1) | EA201590166A8 (enExample) |
| ES (1) | ES2674947T3 (enExample) |
| HR (1) | HRP20180939T1 (enExample) |
| HU (1) | HUE038382T2 (enExample) |
| LT (1) | LT2879672T (enExample) |
| PL (1) | PL2879672T3 (enExample) |
| PT (1) | PT2879672T (enExample) |
| RS (1) | RS57567B1 (enExample) |
| SI (1) | SI2879672T1 (enExample) |
| SM (1) | SMT201800380T1 (enExample) |
| TR (1) | TR201808859T4 (enExample) |
| WO (1) | WO2014020156A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2011001341A (es) | 2008-08-19 | 2011-03-29 | Xenoport Inc | Prodrogas de metil hidrogeno fumarato, sus composiciones farmaceuticas, y metodos de uso. |
| US20130158077A1 (en) | 2011-12-19 | 2013-06-20 | Ares Trading S.A. | Pharmaceutical compositions |
| US9504679B2 (en) | 2011-12-19 | 2016-11-29 | Bjoern Colin Kahrs | Pharmaceutical compositions comprising glitazones and Nrf2 activators |
| EP2887934A1 (en) | 2012-08-22 | 2015-07-01 | XenoPort, Inc. | Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects |
| US9597292B2 (en) | 2012-08-22 | 2017-03-21 | Xenoport, Inc. | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof |
| US10179118B2 (en) | 2013-03-24 | 2019-01-15 | Arbor Pharmaceuticals, Llc | Pharmaceutical compositions of dimethyl fumarate |
| WO2014197860A1 (en) | 2013-06-07 | 2014-12-11 | Xenoport, Inc. | Method of making monomethyl fumarate |
| US9421182B2 (en) | 2013-06-21 | 2016-08-23 | Xenoport, Inc. | Cocrystals of dimethyl fumarate |
| JP2016534133A (ja) | 2013-09-06 | 2016-11-04 | ゼノポート，インコーポレイティド | （ｎ，ｎ−ジエチルカルバモイル）メチル メチル（２ｅ）ブト−２−エン−１，４−ジオエートの結晶形態、その合成方法及び使用 |
| US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
| MA40982A (fr) * | 2014-11-19 | 2017-09-26 | Biogen Ma Inc | Formulation de bille pharmaceutique comprenant du fumarate de diméthyle |
| MA41139B1 (fr) * | 2014-12-11 | 2026-02-27 | Laboratoires Juvise Pharmaceuticals | Combinaison pharmaceutique comprenant du ponesimod et son utilisation dans le traitement de la sclérose en plaque |
| HUE057865T2 (hu) | 2014-12-11 | 2022-06-28 | Actelion Pharmaceuticals Ltd | A poneszimodra, egy szelektív S1P1 receptor agonistára vonatkozó adagolási rend |
| EP4252847A3 (en) | 2016-08-15 | 2023-11-15 | Novartis AG | Regimens and methods of treating multiple sclerosis using ofatumumab |
| JOP20190207A1 (ar) | 2017-03-14 | 2019-09-10 | Actelion Pharmaceuticals Ltd | تركيبة صيدلانية تشتمل على بونيسيمود |
| US11446055B1 (en) | 2018-10-18 | 2022-09-20 | Lumoptik, Inc. | Light assisted needle placement system and method |
| TR201820976A2 (tr) * | 2018-12-28 | 2020-07-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Fi̇ngoli̇mod ve bi̇r spazmoli̇ti̇k i̇çeren farmasöti̇k kombi̇nasyonlar |
| TW202116297A (zh) * | 2019-07-03 | 2021-05-01 | 西班牙商布爾奴爾法碼有限公司 | 組合療法之方法、組成物與套組 |
| JP7794735B2 (ja) * | 2019-09-11 | 2026-01-06 | ノバルティス アーゲー | 切替え療法によるｒｍｓの治療 |
| US20230099229A1 (en) | 2020-03-13 | 2023-03-30 | Reprise Pharmaceuticals, Inc. | Methods of treating multiple sclerosis |
| AR122023A1 (es) * | 2020-05-06 | 2022-08-03 | Imcyse Sa | Péptidos y métodos para el tratamiento de esclerosis múltiple |
| CN116672325B (zh) * | 2023-06-06 | 2024-09-03 | 哈尔滨工业大学 | 一种包覆中性粒细胞膜的聚芬戈莫德纳米前药的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080227847A1 (en) | 2005-07-07 | 2008-09-18 | Aditech Pharma Ab | Novel Salts of Fumaric Acid Monoalkylesters and Their Pharmaceutical Use |
| WO2007042034A1 (en) * | 2005-10-07 | 2007-04-19 | Aditech Pharma Ab | Controlled release pharmaceutical compositions comprising a fumaric acid ester |
| EP2564839B1 (en) | 2009-01-09 | 2016-05-11 | Forward Pharma A/S | Pharmaceutical formulation comprising one or more fumaric acid esters in an erosion matrix |
| DK2533634T3 (en) | 2010-02-12 | 2016-01-25 | Biogen Ma Inc | NEURO PROTECTIVE demyelinating diseases |
| US20130259856A1 (en) * | 2012-03-27 | 2013-10-03 | Teva Pharmaceutical Industries, Ltd. | Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate |
-
2012
- 2012-08-03 EP EP12179232.9A patent/EP2692343A1/en not_active Withdrawn
- 2012-10-10 EP EP12187939.9A patent/EP2692344A1/en not_active Withdrawn
-
2013
- 2013-08-02 WO PCT/EP2013/066285 patent/WO2014020156A1/en not_active Ceased
- 2013-08-02 DK DK13745073.0T patent/DK2879672T3/en active
- 2013-08-02 PL PL13745073T patent/PL2879672T3/pl unknown
- 2013-08-02 PT PT137450730T patent/PT2879672T/pt unknown
- 2013-08-02 CN CN201380052107.4A patent/CN104684553A/zh active Pending
- 2013-08-02 EA EA201590166A patent/EA201590166A8/ru unknown
- 2013-08-02 US US14/419,031 patent/US20150164849A1/en not_active Abandoned
- 2013-08-02 KR KR20157005612A patent/KR20150040338A/ko not_active Ceased
- 2013-08-02 SI SI201331068T patent/SI2879672T1/sl unknown
- 2013-08-02 CA CA2880742A patent/CA2880742C/en active Active
- 2013-08-02 CA CA3107367A patent/CA3107367A1/en not_active Abandoned
- 2013-08-02 EP EP13745073.0A patent/EP2879672B1/en active Active
- 2013-08-02 ES ES13745073.0T patent/ES2674947T3/es active Active
- 2013-08-02 CN CN201710423062.7A patent/CN107669668A/zh active Pending
- 2013-08-02 TR TR2018/08859T patent/TR201808859T4/tr unknown
- 2013-08-02 RS RS20180737A patent/RS57567B1/sr unknown
- 2013-08-02 EP EP18166347.7A patent/EP3398595A1/en not_active Withdrawn
- 2013-08-02 SM SM20180380T patent/SMT201800380T1/it unknown
- 2013-08-02 HU HUE13745073A patent/HUE038382T2/hu unknown
- 2013-08-02 LT LTEP13745073.0T patent/LT2879672T/lt unknown
- 2013-08-02 HR HRP20180939TT patent/HRP20180939T1/hr unknown
- 2013-08-02 AU AU2013298517A patent/AU2013298517A1/en not_active Abandoned
- 2013-08-02 JP JP2015524803A patent/JP2015523407A/ja active Pending
- 2013-08-02 KR KR1020217038002A patent/KR20210147083A/ko not_active Ceased
- 2013-08-02 KR KR1020207035758A patent/KR20200142597A/ko not_active Ceased
- 2013-08-02 CN CN202110575106.4A patent/CN113288891A/zh active Pending
-
2018
- 2018-03-14 AU AU2018201801A patent/AU2018201801B2/en not_active Ceased
- 2018-06-05 JP JP2018107836A patent/JP2018150375A/ja active Pending
- 2018-11-28 US US16/202,851 patent/US20190091190A1/en not_active Abandoned
-
2020
- 2020-02-21 AU AU2020201290A patent/AU2020201290B2/en not_active Ceased
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