WO2014010679A1 - Endoprothèse vasculaire - Google Patents

Endoprothèse vasculaire Download PDF

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Publication number
WO2014010679A1
WO2014010679A1 PCT/JP2013/069003 JP2013069003W WO2014010679A1 WO 2014010679 A1 WO2014010679 A1 WO 2014010679A1 JP 2013069003 W JP2013069003 W JP 2013069003W WO 2014010679 A1 WO2014010679 A1 WO 2014010679A1
Authority
WO
WIPO (PCT)
Prior art keywords
stent
bulging portion
resin
cover member
tubular organ
Prior art date
Application number
PCT/JP2013/069003
Other languages
English (en)
Japanese (ja)
Inventor
秀英 豊川
京典 白川
Original Assignee
株式会社パイオラックスメディカルデバイス
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社パイオラックスメディカルデバイス filed Critical 株式会社パイオラックスメディカルデバイス
Priority to JP2014524871A priority Critical patent/JP5813230B2/ja
Publication of WO2014010679A1 publication Critical patent/WO2014010679A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/848—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having means for fixation to the vessel wall, e.g. barbs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2002/045—Stomach, intestines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A61F2002/072—Encapsulated stents, e.g. wire or whole stent embedded in lining
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155—Adjacent bands being connected to each other
    • A61F2002/91558—Adjacent bands being connected to each other connected peak to peak
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008—Fixation appliances for connecting prostheses to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0039—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in diameter

Definitions

  • the present invention relates to a stent for preventing stenosis or occlusion of a tubular organ, rupture of an aneurysm, etc. by being placed in a tubular organ such as a bile duct, ureter, trachea, blood vessel, etc., and particularly suitable for a digestive system covered stent.
  • a tubular organ such as a bile duct, ureter, trachea, blood vessel, etc.
  • This type of stent is, for example, attached to a sheath or catheter, etc. with the stent contracted in diameter, transported to a target position in a body tissue such as a bile duct, and then pushed out from the sheath or catheter to self-expand the stent.
  • the balloon placed inside the stent is inflated to expand the diameter, thereby being placed in close contact with the inner wall of the tubular organ.
  • Patent Document 1 described below describes a stent formed of a plurality of wires, and between the one end and the other end of the stent is larger than the diameter of the same end and the other end.
  • a central spherical region bulging in the outer diameter direction is provided so as to increase the diameter.
  • Inside this central spherical region is a void. The central spherical region is in close contact with the inner wall of the blood vessel, so that the stent is positioned and placed in the cardiovascular vessel.
  • the stent of Patent Document 1 has a shape in which the central portion swells in a spherical shape so as to match the inner peripheral shape of the blood vessel of the heart, and bites into the inner wall of the tubular organ for the purpose of anchoring effect. It does not form a protruding shape.
  • a part of the stent protrudes to give an anchoring effect.
  • the protruding part has a shape that pierces the inner wall of the tubular organ sharply, it becomes difficult to remove the stent when it is necessary to remove the stent. .
  • the bulging portion when the protruding portion has a shape that gently bulges, the bulging portion may be deformed and easily displaced.
  • a stent of the present invention is placed in a tubular organ, has a tubular shape as a whole, and has a metal stent body having bulged portions at a plurality of locations on the outer periphery, A resin cover member covering at least the outer periphery and / or inner periphery including the bulging portion of the stent body, and a void is formed inside the bulging portion, and the inner peripheral surface is filled with resin. It is characterized by being.
  • the cover member is formed so as to cover the outer periphery and inner periphery of the stent body, the portion covering the outer periphery is formed of silicone, and the portion covering the inner periphery is formed of polyurethane. Preferably it is.
  • the bulging portion reinforced with the resin is in close contact with the inner wall of the tubular organ to improve the anchoring effect, so that the movement of the stent is effectively suppressed, and the stent is fixed over a long period of time. Can be stably placed at the position.
  • the stent when it becomes necessary to remove the stent due to a blockage or the like, the stent is grasped and pulled with a medical gripper such as a snare or forceps inserted through a catheter, etc. Since the bulging portion is deformed and easily separated from the inner wall of the tubular organ, the stent can be easily removed.
  • a medical gripper such as a snare or forceps inserted through a catheter, etc. Since the bulging portion is deformed and easily separated from the inner wall of the tubular organ, the stent can be easily removed.
  • FIG. 1 shows an embodiment of the stent of the present invention, and is a perspective view in a state where a part thereof is broken.
  • FIG. It is a perspective view of the stent main body which comprises the stent.
  • the stent main body which comprises the stent is shown, (a) The development view, (b) is the development view of the stent main body in another example.
  • (A) is a principal part top view of the stent of this invention, (b) is a principal part side view of the stent.
  • A) is a cross-sectional view taken along the line AA in FIG. 1, and (b) is a cross-sectional view taken along the line BB in FIG.
  • the stent 10 in this embodiment includes a metal stent body 20 having bulged portions 30 at a plurality of locations on the outer periphery, and at least the bulged portion of the stent body 20. And a resin cover member 40 covering the outer periphery and / or the inner periphery including 30.
  • the stent body 20 is formed in a mesh shape by processing a metal cylinder by laser processing, etching, or the like.
  • the pattern shape of the mesh is not particularly limited as long as the diameter can be reduced and expanded, but for example, the shapes shown in the developed views of FIGS. 3A and 3B are preferably employed.
  • a circumferential unit 23 in which a plurality of frame-like bodies 22 are connected in the circumferential direction is connected in the axial direction via a plurality of connecting portions 25 to form a cylindrical shape.
  • a wave-like or frame-like pattern is connected in the circumferential direction to form a circumferential unit, and this circumferential unit is connected in the axial direction to form a tubular shape as a whole.
  • the stent body 20 of this embodiment is formed by processing a metal cylinder.
  • a plurality of circumferential units 23 each having a zigzag portion 21 and a frame body 22 are formed by processing a metal plate. Then, the metal plate may be formed to be bent into a cylindrical shape.
  • the material of the stent main body 20 made of metal is not particularly limited.
  • the metal cylinder or metal plate is processed into a cylindrical shape as described above, it is attached to a predetermined mold and subjected to heat treatment or press molding, so that a bulging portion is formed on the outer periphery thereof as shown in FIG.
  • the stent body 20 used in the present invention can be obtained.
  • a shape memory alloy is employed, a self-expanding stent body 20 that is always expanded in diameter can be obtained by performing a shape memory process.
  • a void 31 is formed inside the bulging portion 30 of the stent body 20.
  • the stent body 20 of this embodiment is a self-expanding type that is normally in an expanded state, it is attached to a balloon catheter or the like and expanded by inflating a balloon disposed inside the stent.
  • the diameter of the balloon may be increased.
  • the cover member 40 is formed so as to cover at least a portion including the bulging portion of the stent body 20. In this embodiment, almost the entire stent body 20 is covered with a cover member. However, for example, at the branching portion of the tubular organ, the stent body 20 is partially formed so as not to disturb the flow of the branched tubular organ. It may have an exposed shape.
  • the cover member 40 in this embodiment includes an inner layer 41 covering the inner peripheral side of the stent main body 20, an outer layer 43 covering the outer peripheral side of the stent main body 20, and a bulging portion. 30 and the resin 70 filled in the inner periphery.
  • the bulging portion in which the bulging portion 30 of the stent body 20 is covered with the cover member 40 will also be described as the bulging portion 30.
  • the bulging portion 30 extends with a predetermined width in the circumferential direction and a predetermined length in the axial direction, and smoothly protrudes so as to gradually become lower. It is preferable to make the shape. Further, the bulging portions 30 are arranged at a plurality of locations at predetermined intervals along the circumferential direction of the stent body 20, and are arranged at a plurality of locations at predetermined intervals along the axial direction.
  • the stent body 20 is preferably disposed at a position where it does not overlap when viewed in the axial direction from the end face of the stent body 20.
  • the bulging part 30 is arrange
  • the arrangement shape of the bulging portion 30 is not particularly limited.
  • the bulging portion 30 is formed at two locations facing the circumferential direction of the stent body 20, and
  • the bulging portions 30 arranged in the circumferential direction may be further provided at a plurality of locations at predetermined intervals in the axial direction and at an angle of 90 degrees from each other when viewed from the axial direction.
  • the bulging parts 30 arranged in such a circumferential direction include: Further, it may be provided at a plurality of locations at predetermined intervals in the axial direction and at an angle of 45 degrees from each other when viewed from the axial direction. As described above, when the stent body 20 is viewed from the axial end surface, the bulging portions 30 adjacent in the axial direction are preferably disposed at positions that do not overlap each other.
  • the bulging portion 30 in this embodiment has a tapered shape with a sharp tip 61 in the axial direction, and the side edges 63 and 63 are curved while drawing a curve. It is formed in a substantially water droplet shape having a diameter that gradually increases toward the direction base end side. And when arrange
  • the outer periphery of the bulging portion 30 along the axial direction of the stent body 20 gradually rises higher from the tip 61 side and rises to the top 65 (stent body). 20 which is the highest projecting portion on the outer periphery of the outer periphery 20), and gradually becomes lower from the topmost portion 65 toward the base end side.
  • the inclination of the bulging portion 30 along the axial direction of the stent body 20 is a slope in the extraction direction of the stent 10 with respect to the topmost portion 65, that is, the axis. So that the slope of the tip-side slope 67 from the tip 61 in the direction to the top 65 is gentler than the slope on the opposite side, that is, the base slope 69 from the top 65 to the axial base. Is formed.
  • the length of the bulging portion 30 along the axial direction of the stent body 20 is formed larger than the width along the circumferential direction of the bulging portion 30.
  • the formation method of the cover member 40 is not particularly limited.
  • the cover body 40 is formed by coating the stent body 20 with a predetermined resin material by dipping or coating.
  • the bulging portion 30 of the stent body 20 is previously coated with the resin 70 and adhered to a predetermined thickness
  • a method of forming a resin film for forming the inner layer 41 by dipping or coating and further forming a resin film for forming the outer layer 43 by dipping or coating may be employed.
  • a resin film that forms the inner layer 41 is formed on the stent body 20 by dipping or coating, and further, a resin film that forms the outer layer 43 is formed by dipping or coating, and then a resin 70 is formed on the inner periphery of the bulging portion 30. May be injected and filled.
  • the cover member 40 can also be formed by covering the stent body 20 with a resin tube.
  • the resin 70 may be injected and adhered to the inner periphery of the bulging portion 30.
  • the cover member 40 is configured by an inner layer 41 and an outer layer 43. Is embedded in them.
  • the resin film of the inner layer 41 is formed so as to cover the inner peripheral side opening of the bulging portion 30, and the resin 70 is attached to the inner periphery of the stent body 20 relatively thickly.
  • the outer periphery is covered with the resin film of the inner layer 41, and the entire structure is further covered with the resin film of the outer layer 43.
  • a space 31 surrounded by each resin film is formed.
  • a resin is used so that the cover member 40 is thickened on the inner peripheral surface of the gap 31 formed inside the bulging portion 30 of the stent body 20. 70 is formed, and the thickness T1 of the bulging portion 30 of the cover member 40 is formed to be thicker than the thickness T2 of the bulging portion 30 of the cover member 40 when the resin 70 is not filled. Has been.
  • the inner volume of the bulging portion 30 of the stent body 20 in a state where the cover member 40 is not provided is 100%.
  • the filling ratio of the resin 70 with respect to the volume is preferably 10 to 60%, and more preferably 20 to 50%.
  • the filling rate is less than 10%, the anchoring performance when the stent 10 is placed in the tubular organ cannot be sufficiently improved, and when the filling rate exceeds 60%, the bulging portion The deformability of 30 is lowered, and it becomes difficult to mount the stent 10 on a sheath, a catheter or the like.
  • the resin 70 is thin at the tip end in the axial direction and is thick toward the base end side in the axial direction (see FIG. 6), and is thick at the center in the circumferential direction.
  • the inner peripheral surface of the bulging portion 30 is filled so as to become thinner toward the surface (see FIG. 5).
  • the bile duct V2 and the pancreatic duct V3 branch out from the duodenum V1, and in this embodiment, a case where the stent 10 is placed in the bile duct V2 will be described.
  • the stent 10 of the present invention can be applied to various tubular organs such as the trachea, esophagus, large intestine, and blood vessels other than the bile duct V2, but is particularly suitable as a stent for a digestive system tubular organ. .
  • the diameter of the stent 10 is reduced and accommodated in the inner periphery of the distal end portion of a medical tube (not shown) such as a sheath or catheter so that the distal end 61 side of the bulging portion 30 of the stent 10 faces the proximal end side of the medical tube. .
  • a medical tube such as a sheath or catheter
  • the bulging portion 30 may have some degree of deformability. It is possible to improve the mountability when the stent 10 is attached to a sheath, a catheter, or the like. Further, the above effect can be further enhanced by setting the filling ratio of the resin 70 to the inner volume in a state where the cover member 40 of the bulging portion 30 is not provided to 10 to 60%.
  • an endoscope (not shown) is moved to the duodenum V1 through the oral cavity, stomach or the like by a well-known method, a guide wire (not shown) is introduced into the bile duct V2 through the lumen of the endoscope, and the distal end thereof is connected to the bile duct V2. To reach a position slightly beyond the constricted affected area.
  • the medical tube containing the stent 10 is transported through the guide wire, and the distal end thereof reaches the affected part of the bile duct V2.
  • a pusher or the like is inserted into the medical tube, and the stent 10 is pushed out from the distal end of the medical tube via the pusher or the like, so that the diameter of the stent 10 is expanded as shown in FIG.
  • the stent body 20 is formed in a mesh shape by processing a metal cylinder, the total length is hardly changed between the diameter reduction and the diameter expansion, and the shortening is less likely to occur. Can be accurately placed at a predetermined position of a tubular organ such as the bile duct V2 while suppressing displacement.
  • the bulging part 30 is arrange
  • the stent 10 When the lumen of the stent 10 is blocked with a bodily fluid such as bile or the treatment is completed and the stent 10 is to be removed from the tubular organ, for example, the stent 10 protrudes from the opening of the bile duct V2. A portion (see FIG. 8) or a predetermined portion of the stent 10 is grasped by a medical snare or a medical treatment clamp, and the stent 10 is pulled out from the bile duct V2 and pulled out to the duodenum V1 side. The stent 10 can be removed and the stent 10 can be removed from the body.
  • the bulging portion 30 can be relatively easily deformed and easily separated from the inner wall of the bile duct V2 by the gap 31 formed inside the bulging portion 30.
  • the stent 10 can be easily removed.
  • the bulging portion 30 since the bulging portion 30 has a shape that protrudes smoothly so as to gradually rise and gradually lower, the stent 10 can be extracted from the bile duct V2 relatively smoothly, and Since the distal end side inclined surface 67 of the portion 30 is formed more gently than the proximal end side inclined surface 69 (see FIG. 4B), the bulging portion 30 adheres to the inner wall without being caught by the inner wall of the bile duct V2. The stent 10 can be extracted smoothly from the bile duct V2. Furthermore, since the axial length of the bulging portion 30 is formed to be larger than the width along the circumferential direction (see FIG. 4A), a large contact area with the inner wall of the tubular organ is ensured in the axial direction. The anchoring effect on the tubular organ can be enhanced, and the stent 10 can be easily extracted from the tubular organ due to the long shape in the axial direction.
  • the filling rate of the resin 70 with respect to the volume of the void 31 in the bulging portion 30 formed in the stent main body 20 is 10 to 60%, so that it is in the tubular organ such as the bile duct V2. Anchoring performance when the stent 10 is indwelled and extractability when the stent 10 is taken out from the tubular organ can be obtained with a good balance.
  • the inner layer 41 that forms the inner side of the cover member 40 is formed of polyurethane and the outer layer 43 that forms the outer side of the cover member 40 is formed of silicone
  • the inner layer 41 formed of polyurethane allows body fluids such as bile to flow.
  • the outer layer 43 formed of silicone that is not hydrolyzed protects the inner layer 41 made of polyurethane that is easily hydrolyzed, and prevents the cover member 40 from being blocked. Durability can be increased.
  • the stent body 20 is formed in a mesh shape by processing a metal cylinder, but by filling the space 70 inside the bulging portion 30 with the resin 70, the following The effect is brought about. That is, for example, when the stent 10 having the above structure is placed at a bent portion of the tubular organ, the corners and ends of the mesh pattern tend to protrude outward particularly in the bulging portion 30. However, since the inner peripheral surface of the bulging portion 30 is filled with the resin 70 so as to make the cover member 40 thicker, the thicker cover member 40 causes the corners and ends of the mesh pattern to be outward. Can be suppressed, and the pullability when the stent 10 is taken out from the body can be maintained well.
  • the resin 70 filled in the gap 31 of the bulging portion 30 is mixed with a material for imparting contrast, the contrast is imparted to the bulging portion 30 of the stent 10.
  • the hardness of the resin 70 at that portion can be increased, and the anchoring effect of the stent 10 on the inner wall of the tubular organ by the bulging portion 30 can be further improved.
  • FIG. 9 illustrates another embodiment of the stent of the present invention. Note that substantially the same parts as those of the above-described embodiment are denoted by the same reference numerals, and description thereof is omitted.
  • the stent 10a of this embodiment is different from the above-described embodiment in that the bulging portion 30a has a shape that smoothly bulges so as to be substantially elliptical as a whole.
  • the bulging portion 30a is provided at a location facing the circumferential direction of the stent body 20, or four bulging portions 30a are provided at equal intervals in the circumferential direction of the stent body 20. Also good.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

L'objectif de la présente invention est de proposer une endoprothèse vasculaire qui peut être placée en toute sécurité en une position prescrite dans un organe tubulaire de façon à ne pas glisser de sa position, et qui peut être facilement retirée du corps lorsqu'un retrait devient nécessaire. Cette endoprothèse vasculaire (10) est munie des éléments suivants : un corps métallique d'endoprothèse vasculaire (20) qui a une forme globalement cylindrique avec des renflements (30) en une pluralité de sites sur sa surface externe ; et un élément d'enveloppe de résine (40) qui recouvre les surfaces interne et externe du corps d'endoprothèse vasculaire (20), y compris les renflements (30). Des cavités (31) sont formées à l'intérieur des renflements (30), et une résine (70) est disposée sur leurs surfaces internes.
PCT/JP2013/069003 2012-07-13 2013-07-11 Endoprothèse vasculaire WO2014010679A1 (fr)

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JP2014524871A JP5813230B2 (ja) 2012-07-13 2013-07-11 ステント

Applications Claiming Priority (2)

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JP2012157886 2012-07-13
JP2012-157886 2012-07-13

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WO2014010679A1 true WO2014010679A1 (fr) 2014-01-16

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WO (1) WO2014010679A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6093678A (ja) * 1983-10-27 1985-05-25 Canon Inc 記録又は再生装置
WO2016054536A1 (fr) * 2014-10-02 2016-04-07 Boston Scientific Scimed, Inc. Caractéristique de croissance contrôlée pour antimigration
JP2016077884A (ja) * 2014-10-21 2016-05-16 テウン メディカル カンパニー リミテッド 滑り止めステントの製造方法及びそれにより製造された滑り止めステント
EP2977030A4 (fr) * 2013-03-18 2016-09-28 Piolax Medical Devices Inc Endoprothèse
EP3117799A1 (fr) * 2015-07-15 2017-01-18 Cook Medical Technologies LLC Mécanisme anti-migration de stent
CN113056243A (zh) * 2018-11-22 2021-06-29 奥林巴斯株式会社 医疗用支架和支架输送装置
US11759341B2 (en) 2020-01-13 2023-09-19 Boston Scientific Scimed, Inc. Anti-migration stent

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003079743A (ja) * 2001-09-17 2003-03-18 Piolax Medical Device:Kk ステント及びステント付きグラフト
JP2011509805A (ja) * 2008-01-24 2011-03-31 メドトロニック，インコーポレイテッド 人工心臓弁用のステント

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003079743A (ja) * 2001-09-17 2003-03-18 Piolax Medical Device:Kk ステント及びステント付きグラフト
JP2011509805A (ja) * 2008-01-24 2011-03-31 メドトロニック，インコーポレイテッド 人工心臓弁用のステント

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6093678A (ja) * 1983-10-27 1985-05-25 Canon Inc 記録又は再生装置
EP2977030A4 (fr) * 2013-03-18 2016-09-28 Piolax Medical Devices Inc Endoprothèse
WO2016054536A1 (fr) * 2014-10-02 2016-04-07 Boston Scientific Scimed, Inc. Caractéristique de croissance contrôlée pour antimigration
US10219921B2 (en) 2014-10-02 2019-03-05 Boston Scientific Scimed, Inc. Controlled ingrowth feature for antimigration
US20190167453A1 (en) * 2014-10-02 2019-06-06 Boston Scientific Scimed, Inc. Controlled ingrowth feature for antimigration
US11590008B2 (en) 2014-10-02 2023-02-28 Boston Scientific Scimed, Inc. Controlled ingrowth feature for antimigration
JP2016077884A (ja) * 2014-10-21 2016-05-16 テウン メディカル カンパニー リミテッド 滑り止めステントの製造方法及びそれにより製造された滑り止めステント
EP3117799A1 (fr) * 2015-07-15 2017-01-18 Cook Medical Technologies LLC Mécanisme anti-migration de stent
CN113056243A (zh) * 2018-11-22 2021-06-29 奥林巴斯株式会社 医疗用支架和支架输送装置
CN113056243B (zh) * 2018-11-22 2024-06-04 奥林巴斯株式会社 医疗用支架和支架输送装置
US11759341B2 (en) 2020-01-13 2023-09-19 Boston Scientific Scimed, Inc. Anti-migration stent

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