WO2014008692A1

WO2014008692A1 - Ketogenic diet formula milk and preparation method thereof

Info

Publication number: WO2014008692A1
Application number: PCT/CN2012/079488
Authority: WO
Inventors: 廖建湘
Original assignee: Liao Jianxiang
Priority date: 2012-07-10
Filing date: 2012-08-01
Publication date: 2014-01-16
Also published as: CN102715240A; CN102715240B

Abstract

Disclosed are ketogenic diet formula milk and a preparation method of the ketogenic diet formula milk. The ketogenic diet formula milk contains the following components per 100 g: 1.5-12.5 g of fat, 0-5 g of protein, 0-0.5 g of carbohydrate, 0-0.6 g of flavoring, 0-1.2 g of nourishing essence, and the remaining is liquid milk. The preparation method comprises the step of uniformly mixing fat, protein, carbohydrate, flavoring, nourishing essence, and the liquid milk according to the prior art.

Description

Ketone diet formula and preparation method thereof

Technical field

The invention relates to an edible formula and a preparation method thereof, in particular to a treatment for epilepsy, obesity, diabetes, hyperlipemia, various tumor patients, various inflammatory diseases, trauma, behavioral abnormalities, senile dementia, migraine Therapeutic formula for neurodegenerative and degenerative diseases and a preparation method thereof.

Background technique

The ketogenic diet therapy has been used for the treatment of epilepsy for more than 90 years. A large number of clinical cases have proved that the method has obvious curative effect on the treatment of epilepsy, and it is safe, economical, simple and convenient. In addition, ketogenic diet in obesity, diabetes, hyperlipidemia, various tumor diseases, spinal cord injury, brain trauma, inflammatory diseases, behavioral abnormalities such as autism, Rett syndrome, hyperactivity disorder, mania, anxiety disorder, impulsivity Attacks, senile dementia, migraine, neurodegeneration and degenerative diseases have also been significant, and related research and reports are increasing. The ketol diet of the prior art is mainly composed of different nutrient formulas, which is different from the common diet, and the other nutrients other than the three major nutrients of fat, protein and sugar have great differences from the natural properties of human breast milk or animal milk. Causes nutritional imbalances such as hypoproteinemia, vitamin deficiency, low immunity, and lack of minerals. The patient's own ketone diet diet, calculation, weighing, cooking are more troublesome, and the error is larger, because the classic ketogenic diet is strict, accurate weighing, is a high-fat diet, ordinary ketogenic diet Very greasy, poor mouthfeel, difficult to accept and long-term adherence to consumption.

Summary of the invention

The object of the present invention is to provide a ketogenic diet formula and a preparation method thereof, and the technical problem to be solved is to facilitate the use of a ketogenic diet for a user, the nutritional formula is close to physiological needs, and the mouthfeel is easy to be accepted by the user.

The invention adopts the following technical scheme: a ketogenic diet formula containing a mass ratio component: 0.5 to 5 parts of fat, 0.1 to 5 parts of protein + carbohydrate, and 100 g of the liquid of the ketogenic diet milk. It consists of the following components: fat 1.5~12.5g, protein 0~5g, carbohydrate 0～0.5g, seasoning 0～0.6g and nutrient 0～1.2g, the rest is liquid milk; or the ketogenic diet formula The milk solids are composed of the following components: fat 1.5 to 12.5 g, protein 0 to 5 g, carbohydrate 0 to 0.5 g, seasoning 0 to 0.6 g, nutrient 0 to 1.2 g, and de-sweet milk powder 8 to 16 g;

The fat is selected from one or more of medium chain triacylglycerol, edible oil, fatty meat and egg yolk. The edible oil is vegetable oil, butter and butter, and the vegetable oil is palm oil, coconut oil, peanut oil, soybean oil, olive oil, vegetables. Seed oil, tea oil, corn oil and safflower seed oil;

The protein uses one or more of whey protein, soy protein, lean pork, beef, lean poultry, fish, shrimp, eggs and soy products;

The carbohydrate is selected from the group consisting of water-soluble dietary fiber powder corn dietary fiber powder, konjac dietary fiber powder, oat dietary fiber powder, polydextrose powder, inulin, arabinogalactan powder, maltodextrin powder, guar gum powder and More than one of low oligomeric cellulose powders;

The liquid milk is human milk, milk, goat milk, horse milk, camel milk, and the prior art sugar-free milk substitute containing no more than 0.5 gram of sugar per 100 grams of liquid milk;

The seasoning is selected from a non-heating flavoring sweetener, a fruiting agent and/or a salt;

The nutrient is added vitamins, minerals and amino acids; the vitamins are: vitamin A, vitamin D, thiamine, riboflavin, niacin, vitamin C, vitamin E, biotin, pantothenic acid, folic acid, vitamin B12; The minerals are: calcium, phosphorus, sodium, magnesium, iron, zinc, selenium, copper, manganese, potassium, chlorine, iodine, chromium, molybdenum; the amino acids are: proline, methionine, isoleucine, Phenylalanine, leucine, tryptophan, threonine, lysine, histidine, cysteine, tyrosine, arginine.

The liquid material in the liquid milk of the present invention is 28% to 36%, and the balance is water; the solid form is powdery, lumpy or jelly.

Adding vitamin A to every 100 grams of ketogenic diet formula of the present invention It is 0～12.00 micrograms, vitamin D0～300 international unit, thiamine is 0～0.01mg, riboflavin is 0～0.07mg, niacin is 0～0.05mg, vitamin C 0 to 0.5 mg, vitamin E is 0 to 0.11 mg, biotin 0 to 0.3 μg, pantothenic acid 0 to 0.1 mg, folic acid 0 to 4 μg, and vitamin B12 0 to 0.09 μg.

In the 100 g of ketogenic diet of the invention, calcium is added in an amount of 0 to 50.00 mg, phosphorus is 0 to 30.00 mg, sodium is 0 to 20.00 mg, magnesium is 0 to 5.0 mg, iron is 0 to 0.10 mg, and zinc is 0 to 0.20 mg, selenium is 0 to 0.80 μg, copper is 0 to 0.01 mg, manganese is 0 to 0.015 mg, potassium is 0 to 50 mg, chlorine is 0 to 0.15 mg, iodine is 0 to 1.5 μg, and chromium is 0. ~ 0.15 micrograms, molybdenum is 0 ~ 0.15 micrograms.

In the present invention, the dosage of proline is 0-2.5 mg, the methionine is 0-3.5 mg, the isoleucine is 0-2.5 mg, and the phenylalanine is 0-2 mg. Amino acid is 0 to 4 mg, tryptophan is 0 to 1 mg, threonine is 0 to 2 mg, lysine is 0 to 3 mg, histidine is 0 to 3 mg, and cysteine is 0. ~3.5 mg, tyrosine is 0 to 1.5 mg, and arginine is 0 to 30 mg.

The preparation method of the ketogenic diet formula comprises the following steps: according to the mass ratio, the fat is 1.5 to 12.5 g, the protein is 0 to 5 g, the carbohydrate is 0 to 0.5 g, the seasoning is 0 to 0.6 g, and the nutrient is 0 to 1.2. Gram, add liquid milk to a total mass of 100 grams, mix evenly according to the prior art; or add 1.5 to 12.5 grams of fat, 0 to 5 grams of protein, 0 to 0.5 grams of carbohydrates, 0 to 0.6 grams of seasoning, nutrients 0 to 1.2 grams, 8 to 16 grams of de-sweetened milk powder, mixed into powder, block or jelly according to the prior art;

The liquid milk is human milk, milk, goat milk, horse milk, camel milk, and a prior art sugar-free milk substitute containing no more than 0.5 grams of sugar per 100 grams of liquid milk;

Method of the invention Adding vitamin A per 100 grams of ketogenic diet formula It is 0～12.00 micrograms, vitamin D0～300 international unit, thiamine is 0～0.01mg, riboflavin is 0～0.07mg, niacin is 0～0.05mg, vitamin C 0 to 0.5 mg, vitamin E is 0 to 0.11 mg, biotin 0 to 0.3 μg, pantothenic acid 0 to 0.1 mg, folic acid 0 to 4 μg, and vitamin B12 0 to 0.09 μg.

The method of the invention comprises 0 to 50.00 mg of calcium, 0 to 30.00 mg of phosphorus, 0 to 20.00 mg of sodium, 0 to 5.0 mg of magnesium and 0 to 0.10 mg of iron per 100 g of the ketogenic diet. Zinc is 0 to 0.20 mg, selenium is 0 to 0.80 μg, copper is 0 to 0.01 mg, manganese is 0 to 0.015 mg, potassium is 0 to 50 mg, chlorine is 0 to 0.15 mg, and iodine is 0 to 1.5 μg. It is 0 to 0.15 micrograms, and molybdenum is 0 to 0.15 micrograms.

The method of the invention comprises 0-2.5 mg of proline, 0-3.5 mg of methionine, 0-2.5 mg of isoleucine and 0-2 mg of phenylalanine per 100 g of ketogenic diet milk. , leucine is 0 to 4 mg, tryptophan is 0 to 1 mg, threonine is 0 to 2 mg, lysine is 0 to 3 mg, histidine is 0 to 3 mg, cysteine It is 0 to 3.5 mg, tyrosine is 0 to 1.5 mg, and arginine is 0 to 30 mg.

The method of the invention cleans pure lean pork, beef, lean poultry meat, lean fish meat or shrimp meat, cut into a block shape of 2cm×2cm×2cm, and is cooked at 105～110°C for 50-60 minutes. After cooling with cold water to room temperature, the centrifuge is dehydrated to a water content of not more than 20%, vacuum dehydrated at 0.05Mpa, 20 ° C, 2 hours, to a mass water content of not more than 1%, after smashing through 100 sieves, Or cooling with cold water to room temperature, grinding by a colloid mill until the solid particle size is not more than 0.15 mm, the solid content is 40-50%, and then spray drying at an inlet temperature of 250-350 ° C to obtain a protein substance powder;

The cooked egg or tofu is slurried, vacuum dehydrated at 0.05 MPa, 20 ° C, 2 hours, to a mass water content of not more than 1%, and after pulverization, 100 sieves are obtained to obtain a protein raw material powder;

The fat meat is cleaned, cut into pieces of 2cm × 2cm × 2cm, cooked at 105 ~ 110 ° C, 50 ~ 60 minutes, cooled to room temperature by cold water, and then ground to solid by colloidal grinding. The particle size is not more than 0.15 mm, the solid content is 40-50%, and then spray-drying at an inlet temperature of 250-350 ° C to obtain a fatty substance;

The cooked egg yolk is slurried and vacuum-dehydrated at 0.05 MPa, 20 ° C for 2 hours to a mass water content of not more than 1%, and after pulverization, 100 sieves are obtained to obtain a fatty substance.

The method of the present invention obtains a protein raw material powder which is dried by hot air drying, microwave drying, puffing drying or infrared drying.

The liquid milk of the method of the invention is prepared according to the method of Chinese Patent 200810009006.X.

Compared with the prior art, the present invention removes metabolizable sugars from human milk and animal milk as main raw materials, and the nutritional formula is close to physiological needs, and the taste is easy to be accepted by patients, and it is convenient to take, and patients of different ages and normal people can Acceptable, convenient for animal experiments, suitable for the treatment of epilepsy, diabetes, various types of tumors, behavioral abnormalities, autism, cerebrospinal injury, obesity, senile dementia, migraine, neurodegeneration and degenerative diseases, can also be used Normal people lose weight, change the body's main nutrient structure, and animal experiments.

detailed description

The present invention will be further described in detail below with reference to the embodiments.

The ketogenic diet of the present invention comprises a mass ratio component of 0.5 to 5 parts of fat, 0.1 to 5 parts of protein + carbohydrate, and 28% to 36% of solid matter in the formula of the ketogenic diet, and the balance is water. For every 100 grams of ketogenic diet formula, it consists of the following raw materials: 1.5 to 12.5 grams of fat, 0 to 5 grams of protein, 0 to 0.5 grams of carbohydrates, and 0 to 0.6 grams of seasonings. 0 to 0.6% of the mass and 0 to 1.2 g of the nutrient (0 to 1.2% of the mass of the ketogenic diet), and the rest is liquid milk.

The fat is selected from one or more of medium chain triacylglycerol, edible oil, fatty meat (lard) and egg yolk. The edible oil is vegetable oil, butter and butter, and the vegetable oil is palm oil, coconut oil, peanut oil, soybean oil, olive oil. , rapeseed oil, tea oil, corn oil and safflower oil.

The protein is one or more selected from the group consisting of whey protein, soy protein, lean pork, beef, lean poultry, fish, shrimp, eggs, and soy products.

Carbohydrates use water-soluble dietary fiber powder corn dietary fiber powder, konjac dietary fiber powder, oat dietary fiber powder, polydextrose powder, inulin, arabinogalactan powder, maltodextrin powder, guar gum powder and oligomerization More than one type of cellulose powder.

Liquid milk is milk, milk, goat milk or other mammalian milk from which sugar is removed. If the sugar milk is solid powder, it is 8% to 16% solid powder, and water is added to liquid milk. Carbohydrates are carbohydrate monosaccharides and disaccharides that are naturally contained in raw raw milk and can be digested by humans or animals to absorb and supply energy. After removing sugars, sugars containing no more than 0.5 grams per 100 grams of liquid milk are included. .

Other mammalian milks are horse milk, camel milk, and prior art sugar-free milk substitutes.

The seasoning uses a non-heating flavoring sweetener, fruiting agent and/or salt. The sweetener is stevia, sucralose or saccharin. The fruit flavor is strawberry or oatmeal. The ketogenic diet has a sweet, salty, fruity taste such as strawberry or grainy taste such as oatmeal.

Add nutrients to vitamins, minerals and amino acids, specifically:

For every 100 grams of ketogenic diet formula, add vitamin A to 0 to 12.00 micrograms, vitamin D0 to 300 international units, thiamine to 0 to 0.01 mg, riboflavin to 0 to 0.07 mg, and niacin to 0 to 0.05. Mg, vitamin C is 0-0.5 mg, vitamin E is 0-0.11 mg, biotin 0-0.3 micrograms, pantothenic acid 0-0.1 mg, folic acid 0-4 micrograms, vitamin B12 0 to 0.09 micrograms.

For every 100 grams of ketonic diet formula, calcium is added in an amount of 0 to 50.00 mg, phosphorus is 0 to 30.00 mg, sodium is 0 to 20.00 mg, magnesium is 0 to 5.0 mg, iron is 0 to 0.10 mg, and zinc is 0 to 0. 0.20 mg, selenium is 0-0.80 μg, copper is 0-0.01 mg, manganese is 0-0.015 mg, potassium is 0-50 mg, chlorine is 0-0.15 mg, iodine is 0-1.5 micrograms, and chromium is 0-0.15. Micrograms, molybdenum is 0 to 0.15 micrograms.

For each 100 grams of ketogenic diet, 0 to 2.5 mg of proline is added, 0 to 3.5 mg of methionine, 0 to 2.5 mg of isoleucine, 0 to 2 mg of phenylalanine, and leucine. 0 to 4 mg, tryptophan is 0 to 1 mg, threonine is 0 to 2 mg, lysine is 0 to 3 mg, histidine is 0 to 3 mg, and cysteine is 0 to 3.5. Mg, tyrosine is 0 to 1.5 mg, and arginine is 0 to 30 mg.

The method for preparing the ketogenic diet of the present invention comprises the following steps:

First, raw material pretreatment

Wash pure pork, beef, lean poultry, lean fish or shrimp meat, cut into pieces of size 2cm × 2cm × 2cm, cooked at 105 ~ 110 ° C, 50 ~ 60 minutes, cold water shower After cooling to room temperature, the centrifuge is dehydrated to a water content of not more than 20%, vacuum dehydrated at 0.05Mpa, 20 ° C, 2 hours, to a mass water content of not more than 1%, after pulverization, 100 sieves, to obtain protein powder spare. In addition to vacuum drying, it can also be dried by hot air drying, microwave drying, puffing drying, and infrared drying. After cooling with cold water to room temperature, it is ground to a solid particle size of not more than 0.15 mm and a solid content of 40 to 50% by a colloid mill. Then, it is spray-dried at an inlet temperature of 250-350 ° C to obtain a protein raw material powder. .

The cooked egg or bean product (tofu) is slurried, vacuum-dehydrated at 0.05 MPa, 20 ° C, 2 hours, to a mass water content of not more than 1%, and after pulverization, 100 sieves are obtained to obtain a protein raw material powder for use.

The fat meat is cleaned, cut into pieces of 2cm × 2cm × 2cm, cooked at 105 ~ 110 ° C, 50 ~ 60 minutes, cooled to room temperature by cold water, and then ground to solid by colloidal grinding. The particle size is not more than 0.15 mm, the solid content is 40-50%, and then spray-dried at an inlet temperature of 250-350 ° C to obtain a fat substance for use.

The cooked egg yolk is slurried and vacuum-dehydrated at 0.05 MPa, 20 ° C for 2 hours to a mass water content of not more than 1%, and after pulverization, 100 sieves are obtained to obtain a fat substance for use.

Liquid milk is prepared by the method of Chinese Patent 200810009006.X to obtain sugars containing no more than 0.5 grams per 100 grams of liquid milk.

Second, according to the mass ratio, the fat will be 1.5 to 12.5 grams, the protein is 0 to 5 grams, the carbohydrate is 0 to 0.5 grams, the seasoning is 0 to 0.6 grams, the nutrients are 0 to 1.2 grams, and the liquid milk is added to the total mass of 100 grams. The liquid formula is obtained by mixing uniformly according to the prior art. Or 1.5 to 12.5 grams of fat, 0 to 5 grams of protein, 0 to 0.5 grams of carbohydrates, 0 to 0.6 grams of seasonings, 0 to 1.2 grams of nutrients, 8 to 16 grams of de-sweetened milk powder, made into powder according to the prior art. Shape, block or jelly.

The fat is selected from one or more of medium chain triacylglycerol, edible oil, fatty meat and egg yolk. The edible oil is vegetable oil, butter and butter, and the vegetable oil is palm oil, coconut oil, peanut oil, soybean oil, olive oil and rapeseed oil. , tea oil, corn oil and safflower oil.

The protein is one or more selected from the group consisting of whey protein, lean pork, beef, poultry, fish, shrimp, eggs, and soy products.

Other mammalian milks are horse milk, camel milk, and sugar-free milk substitutes.

Nutrients are vitamins, minerals and amino acids, specifically:

For every 100 grams of ketonic diet formula, vitamin A is added from 0 to 12.00 micrograms, vitamin D is from 0 to 300 IU, thiamine is from 0 to 0.01 mg, riboflavin is from 0 to 0.07 mg, and niacin is from 0 to 0.05 mg. Vitamin C It is 0-0.5 mg, vitamin E is 0-0.11 mg, biotin 0-0.3 micrograms, pantothenic acid 0-0.1 mg, folic acid 0-4 micrograms, vitamin B12 0-0.09 micrograms.

3. Liquid or solid ketogenic diet formula, sterilized and packaged according to the prior art liquid or solid production method. The specification is 50-1000 ml in liquid form, and the solid is powdery, and the specification is 10 to 1000 g. It can also be made into a block or a paste.

The ketogenic diet formula of the present invention is applicable to patients, normal persons, and animals. Therapeutic range of diet: epilepsy, diabetes, various types of tumors, behavioral abnormalities, autism, cerebrospinal injury, various inflammatory diseases, senile dementia, migraine, neurodegeneration and degenerative diseases, weight loss, changes in the body's main nutrient structure . The usage is oral. The daily dosage is calculated according to the body weight, according to the weight of 50-90 kcal/day per kilogram of body weight, and is taken three to six times according to the meal time, and the appropriate amount of calories required by the individual is adjusted according to the growth and development. 6 hours to 183 days is a course of treatment. During the ketogenic diet, it is necessary to strictly control the intake of other diets, especially those that are metabolized by the body. The total calories and protein intake are relatively loose and free.

Because the fat mass ratio is 0.5-5 parts and the protein is 0.1-5 parts, the first month of diet can replace the energy-assisted carbohydrates. The total daily intake of energy-supplemented carbohydrates is no more than 10 grams for infants and young children, and no more than 15 for teenagers. Grams, adults do not exceed 20 grams, the total amount of daily increase after the second month is 5 grams, increased to no more than 20 grams per day for infants and young children, no more than 25 grams for teenagers, and no more than 30 grams for adults.

Example 1, rapeseed oil, tea oil, corn oil, safflower seed oil, coconut oil in a total mass ratio of 120 kg, whey protein, lean pork and soy protein in any mass ratio of 2 kg, de-sugar milk plus To 1000 kg, the ratio of fat to protein + carbohydrate is 4:1, and the calorie contains 160 kcal per 100 grams.

Added stevia 0.2%.

According to the formula of 100 grams of ketogenic diet, vitamin A is added at 8.00 micrograms, vitamin D 300 IU, thiamine 0.005 mg, riboflavin 0.03 mg, niacin 0.03 mg, vitamin C 0.25 mg, vitamin E 0.05 mg, biotin 0.2 μg, pantothenic acid 0.05 mg, folic acid 3 μg, vitamin B12 0.05 micrograms.

Calcium is 30.00 mg, phosphorus is 20.00 mg, sodium is 10.00 mg, magnesium is 3.00 mg, iron is 0.05 mg, zinc is 0.10 mg, selenium is 0.40 μg, copper is 0.005 mg, manganese is 0.006 mg, and potassium is 30.0 mg. Chlorine was 0.15 mg, iodine was 1.5 micrograms, chromium was 0.15 micrograms, and molybdenum was 0.15 micrograms.

Production method: After mixing, it is made into liquid ketogenic diet formula, packaged in 250 ml.

Example 2, corn oil, lard, butter and olive oil in a total mass ratio of 80 kg, whey protein, lean poultry, beef and eggs in any mass ratio of 1 kg, de-sweet milk to 1000 kg, fat With a protein to carbohydrate ratio of 3:1, heat contains 114 kcal per 100 grams.

Added 0.1% each of sucralose, salt and oatmeal.

According to the formula of ketone diet per 100 grams, the proline is 1.0 mg, the methionine is 2.0 mg, the isoleucine is 1.5 mg, the phenylalanine is 1.0 mg, the leucine is 3.0 mg, and the color ammonia is added. The acid was 0.5 mg, the threonine was 1.0 mg, the lysine was 2.0 mg, the histidine was 2.0 mg, the cysteine was 2.0 mg, the tyrosine was 1.0 mg, and the arginine was 15.0 mg. Add corn dietary fiber 0.2%.

Example 3, medium chain triacylglycerol, butter, butter and soybean oil in any ratio of 40 kg, corn oil 20 kg, whey protein powder, fish, soy protein, shrimp and eggs in any mass ratio of 1 kg, go Sugar milk powder, de-sugar goat milk powder, and sugar-free horse milk powder are 87 kg by mass ratio of 8:1:1, and water is added to 1000 kg.

Add konjac dietary fiber powder, oat dietary fiber powder, polydextrose powder in any mass ratio, the total amount is 0.1%. The fat to protein + carbohydrate ratio is 2.5:1, and the heat contains 106 kcal per 100 grams.

Production method: mix well and then powder, 300 g cans. When added, the added water is reduced to liquid milk according to the solid mass of 8% to 16%.

Example 4, 40 kg of medium chain triacylglycerol, 20 kg of corn oil, 1 kg of whey protein powder, 800 kg of sugar goat milk, 1 kg of horse milk, 0.5 kg of camel milk, 0.5 kg of human milk, sugar-free milk substitute 0.5 kg, folic acid 14.3 kg, vitamin B12 0.72 kg, add sugar milk to the total mass of 1000 kg (about 121 kg of milk).

Added strawberry flavoring 0.1%.

The arabinogalactan powder, the maltodextrin powder, the guar gum powder and the oligomeric cellulose powder are added in an arbitrary mass ratio, and the total mass is 0.2%. The fat to protein + carbohydrate ratio is 1.5:1, and the heat contains 106 kcal per 100 grams.

Therapeutic example 1, Jiang, Henan, is now 1 year and 9 months. At 5 months, the onset of the disease was diagnosed as infantile spasm. After trying anti-epileptic drugs such as corticotropin, sodium valproate, topiramate, carbamazepine, oxcarbazepine, and nitrazepam, the episode was still uncontrolled. More than 10 episodes of sputum every day, exercise, intelligence and speech growth retardation. It was judged to be refractory epilepsy. At the age of 11 months, the ketogenic diet was started. There was no seizure on the third day. After 12 months, all the western medicines were stopped. After 6 months of treatment, the EEG was reviewed. The results showed that there was no obvious epileptic discharge. The formula of the ketogenic diet Example 1 was taken for the first 3 months, and the ratio of formula fat to protein + carbohydrate of Example 2 was later 3:1. Then, according to the ketogenic diet and the catering method, start 3 days of milk, 1 meal, then 3 days 2 milk, 2 meals, the last 1 milk and 3 meals. According to the daily 75 calories/kg body weight, it has been persisted until now, and there is still no seizure. Now the child has returned to normal, and intelligence, language and exercise are no different from normal children of the same age. It is indicated that the ketogenic diet of the present invention is effective in treating epilepsy and improvement in cognitive function.

Dietary therapy 2, Ji, Guangxi, now 2 years old, developed at 7 months, was diagnosed with tuberous sclerosis. The disease causes a number of organ hamartomas throughout the body due to genetic defects, chronic progression, and a small number can worsen cancer, hydrocephalus, and visceral hemorrhage. The patient had brain spasm and infantile spasms. After trying anti-epileptic drugs Debajin, Kaipulan, corticotropin, phenobarbital, Chinese medicine antelope horn, medlar, medlar, and acupuncture treatment, the episode still can not be controlled, more than 20 times a day, hair development, developmental backward . It was judged to be refractory epilepsy. In November, the ketogenic diet of Example 3 was used for diet therapy, with a 90% reduction in seizures after one week and no seizures after 1 month. After 10 months of follow-up, epilepsy remained unchanged, and the growth and development were basically the same as those of the same age. The EEG was significantly improved and the original peak rhythm disorder disappeared. The hamartoma did not increase. The patient took a ketogenic diet formula of 2.5:1. In addition, the previous child was also diagnosed as secondary autism, ignored, and less communicated with the outside world. After taking the ketogenic formula, the child began to speak slowly, had eye contact with the parents, and was willing to communicate with the children. Played together. The invention is illustrated to be effective in treating epilepsy, tumors and autism.

Diet Case 3, Mr. Huang, a native of Hubei, suffered from brain and spinal cord injury caused by a car accident at the age of 22, and the normal diet could not normally digest and absorb energy. The body was very weak. He started eating the ketogenic diet of Example 3 for 2 weeks, according to 60 calories per day. Kg weight, fat and protein + carbohydrate ratio of 2:1, the body condition is getting better, now has recovered better, the weight has returned to the weight before the car accident, mental state is also good, build confidence. The ketogenic diet of the present invention is effective in the adjuvant treatment of brain and spinal cord trauma.

Dietary therapy 4, Lin, Shenzhen, 11 years old, diagnosed with type 1 diabetes 2 weeks ago, the fasting blood glucose was 11.34±3.65mmol/L, 17.09±4.68mmol/L at 2h after meal, and was implemented at 11 years old. The ketogenic diet of Example 3 for 4 weeks, the ratio of fat to protein + carbohydrate was 2.5:1, the fasting blood glucose was stable at 7.29±1.33mmol/L, and the blood glucose at 2h after meal was stable at 9.25±2.24mmol/L. The ketogenic diet was reduced before the milk, and the fluctuation was small, the amount of insulin was also reduced by 22%, and the body weight was basically unchanged. It is indicated that the ketogenic diet of the present invention is effective in treating diabetes.

Diet therapy example 5, Zengmou, Female, 12 months, hospitalized for refractory epilepsy with pneumonia, antiepileptic drugs, antibacterial therapy and symptomatic supportive treatment, the effect is not good, fever lasts for 10 days, cough is severe, and seizures increase to more than 10 times a day. The patient is suffering from abnormal pains and cannot eat or sleep well. The ketogenic diet formula of Example 4 was administered and fasted for 30 hours. All intravenous infusion fluids contained no glucose, and oral administration also minimized sugar-containing drugs. The child fell asleep that night, the fever stopped, and the seizure stopped. After fasting, the ratio of fat to protein + carbohydrate was given. The formula of 1.5:1 ketogenic diet gradually increased the calorie, and the pneumonia was discharged from the hospital. The seizure was reduced by more than 90% for one month. Growth and development progress. The ketogenic diet of the present invention is effective for both inflammatory diseases and refractory epilepsy.

In addition, randomized random use of the five antiepileptic drugs carbamazepine, valproic acid, topiramate, lamotrigine, oxcarbazepine or levetiracetam, 30 patients with ineffective epilepsy, age 2 Between the months of the age of 70 and the age of 70, after using the above-mentioned drugs for 3 months to 2 years, the ketogenic diet of the present invention is administered in three to six times according to the meal time, and the ketogenic formula is taken for 3 months. After 1 year, the effective rate of treatment for patients with more than half of epileptic seizures was 55%, and that for patients without seizures was 10%. The time to control the onset is measured in a period of not less than 3 months.

Using the ketogenic diet of the present invention for the adjuvant treatment of diabetes, 30 patients aged 2 to 18 years old, taking three to six times according to the meal time, taking the ketogenic diet milk for 3 months to 1 year, The patient's quality of life improved, blood sugar was more stable, insulin or hypoglycemic agents decreased, and the effective rate was 40.7%.

Using the ketogenic diet of the present invention for adjuvant treatment of tumors, 30 patients aged between 1.5 and 50 years old, taking three to six times according to meal time, taking ketogenic diet milk for 3 months to 1 year, The patient's quality of life improved, the tumor volume decreased, the type and dose of chemotherapy drugs decreased, and the effective rate was 42.3%.

The ketogenic diet formula of the present invention is one of the comprehensive treatment measures for behavioral abnormality, 31 patients aged 4 to 18 years old, taking three to six times according to meal time, taking ketogenic diet milk for 3 months to After 1 year, the impulse, attack, and hyperactivity were alleviated, and each of the 31 trials was effective.

Using the ketogenic diet of the present invention for the treatment of 25 cases of autism, 30 cases of 2 years old and 18 years old, taking three to six times according to the meal time, taking the ketogenic diet for 3 months to 1 year. After that, social skills improved.

Using the ketogenic diet of the present invention for cerebrospinal injury, encephalitis, meningitis, hypoxic-ischemic injury and traumatic adjuvant therapy, aged from 1 day to 78 years old, observed in 33 cases, divided into three to six times according to meal time After taking the ketogenic diet for 3 months to 1 year, the hospitalization date was shortened and 20 cases were effective.

Using the ketogenic diet of the present invention for inflammatory diseases, acute gastroenteritis, diarrheal diseases, and other measures, 32 cases were observed, taken three to six times according to meal time, and taking ketogenic diet milk for 6 hours to 1 week. After that, the diarrhea course was shortened by 21% and the antidiarrheal drug was reduced by 80%.

The ketogenic diet formula of the invention reduces body weight and controls total calories, and is limited to 70-75% of the same age calories, and is taken three to six times according to the meal time, 30 cases lose weight by 100%, and the average of 2 months is 2 months. The person is reduced by 2 kg.

Using the ketogenic diet of the present invention to change the body's main nutrients to control the total calories, limited to 85% of the same age calorie needs, three to six times according to meal time, 30 cases of weight loss effect 100%, 2 months average reduction 1.5 kg, the body fat ratio decreased by 21%.

The ketogenic diet of the present invention is a liquid, solid, powder or lumps. The ketogenic diet of the prior art has a short shelf life and is not very convenient for storage and transportation. The ketogenic diet of the present invention can be directly eaten, stored, transported, has a long shelf life, and is more convenient and practical to eat. The invention solves the problems of the prior art ketogenic diet (other than the three major nutrients), the non-mother emulsification of other nutrients, the strict proportion of diet therapy, and the limitation of food selection, and is suitable for all ages.

Claims

A ketogenic diet formula containing a mass ratio component of 0.5 to 5 parts of fat and 0.1 to 5 parts of protein + carbohydrate, characterized in that: 100 parts per 100 grams of the ketogenic diet liquid milk is composed of the following group Composition: fat 1.5～12.5g, protein 0～5g, carbohydrate 0～0.5g, seasoning 0～0.6g and nutrient 0～1.2g, the rest is liquid milk; or the ketogenic diet formula solid It is composed of the following components: fat 1.5～12.5g, protein 0～5g, carbohydrate 0～0.5g, seasoning 0～0.6g, nutrient 0～1.2g, de-sugar milk powder 8～16g;

The fat is selected from one or more of medium chain triacylglycerol, edible oil, fatty meat and egg yolk. The edible oil is vegetable oil, butter and butter, and the vegetable oil is palm oil, coconut oil, peanut oil, soybean oil, olive oil, vegetables. Seed oil, tea oil, corn oil and safflower seed oil;

The protein uses one or more of whey protein, soy protein, lean pork, beef, lean poultry, fish, shrimp, eggs and soy products;

The carbohydrate is selected from the group consisting of water-soluble dietary fiber powder corn dietary fiber powder, konjac dietary fiber powder, oat dietary fiber powder, polydextrose powder, inulin, arabinogalactan powder, maltodextrin powder, guar gum powder and More than one of low oligomeric cellulose powders;

The liquid milk is human milk, milk, goat milk, horse milk, camel milk, and a prior art sugar-free milk substitute containing no more than 0.5 grams of sugar per 100 grams of liquid milk;

The seasoning is selected from a non-heating flavoring sweetener, a fruiting agent and/or a salt;

The nutrients are vitamins, minerals and amino acids; the vitamins are: vitamin A, vitamin D, thiamine, riboflavin, niacin, vitamin C, vitamin E, biotin, pantothenic acid, folic acid, vitamin B12; The minerals are: calcium, phosphorus, sodium, magnesium, iron, zinc, selenium, copper, manganese, potassium, chlorine, iodine, chromium, molybdenum; the amino acids are: proline, methionine, isoleucine, benzene Alanine, leucine, tryptophan, threonine, lysine, histidine, cysteine, tyrosine, arginine.
The ketogenic diet according to claim 1, wherein the liquid milk has a solid matter of 28% to 36%, and the balance is water; and the solid is powdery, lumpy or jelly.
The ketogenic diet formula according to claim 1, wherein: the per 100 g of the ketogenic diet formula comprises: vitamin A of 0 to 12.00 μg, thiamine of 0 to 0.01 mg, and nuclear yellow. The prime is 0-0.07 mg, the niacin is 0-0.05 mg, the vitamin C is 0-0.5 mg, the vitamin E is 0-0.11 mg, the biotin is 0-0.3 microgram, the pantothenic acid is 0-0.1 mg, and the folic acid is 0-4 microgram. Vitamin B12 0 to 0.09 micrograms; the per 100 grams of ketogenic diet formula, adding: calcium is 0 to 50.00 mg, phosphorus is 0 to 30.00 mg, sodium is 0 to 20.00 mg, magnesium is 0 to 5.0 mg, and iron is 0. ~0.10 mg, zinc is 0-0.20 mg, selenium is 0-0.80 μg, copper is 0-0.01 mg, manganese is 0-0.015 mg, potassium is 0-50 mg, chlorine is 0-0.15 mg, and iodine is 0- 1.5 micrograms, chromium is 0-0.15 micrograms, molybdenum is 0-0.15 micrograms; the per 100-gram ketogenic diet formula is added: proline is 0-2.5 mg, methionine is 0-3.5 mg, iso-amylamine The acid is 0 to 2.5 mg, the phenylalanine is 0 to 2 mg, the leucine is 0 to 4 mg, the tryptophan is 0 to 1 mg, the threonine is 0 to 2 mg, and the lysine is 0 to 3 mg, histidine is 0 to 3 mg, cysteine is 0 to 3.5 mg, tyrosine is 0 to 1.5 mg, and arginine is 0 to 30 mg.
The preparation method of the ketogenic diet formula comprises the following steps: according to the mass ratio, the fat is 1.5 to 12.5 g, the protein is 0 to 5 g, the carbohydrate is 0 to 0.5 g, the seasoning is 0 to 0.6 g, and the nutrient is 0 to 1.2. Gram, add liquid milk to a total mass of 100 grams, mix evenly according to the prior art; or add 1.5 to 12.5 grams of fat, 0 to 5 grams of protein, 0 to 0.5 grams of carbohydrates, 0 to 0.6 grams of seasoning, nutrients 0 to 1.2 grams, 8 to 16 grams of de-sweetened milk powder are mixed into powder, block or jelly;

The fat is selected from one or more of medium chain triacylglycerol, edible oil, fatty meat and egg yolk. The edible oil is vegetable oil, butter and butter, and the vegetable oil is palm oil, coconut oil, peanut oil, soybean oil, olive oil, vegetables. Seed oil, tea oil, corn oil and safflower seed oil;

The protein uses one or more of whey protein, soy protein, lean pork, beef, lean poultry, fish, shrimp, eggs and soy products;

The carbohydrate is selected from the group consisting of water-soluble dietary fiber powder corn dietary fiber powder, konjac dietary fiber powder, oat dietary fiber powder, polydextrose powder, inulin, arabinogalactan powder, maltodextrin powder, guar gum powder and More than one of low oligomeric cellulose powders;

The liquid milk is human milk, milk, goat milk, horse milk, camel milk, and a prior art sugar-free milk substitute containing no more than 0.5 grams of sugar per 100 grams of liquid milk;

The seasoning is selected from a non-heating flavoring sweetener, a fruiting agent and/or a salt;

The nutrient is added vitamins, minerals and amino acids; the vitamins are: vitamin A, vitamin D, thiamine, riboflavin, niacin, vitamin C, vitamin E, biotin, pantothenic acid, folic acid, vitamin B12; The minerals are: calcium, phosphorus, sodium, magnesium, iron, zinc, selenium, copper, manganese, potassium, chlorine, iodine, chromium, molybdenum; the amino acids are: proline, methionine, isoleucine, Phenylalanine, leucine, tryptophan, threonine, lysine, histidine, cysteine, tyrosine, arginine.
The preparation method of the ketogenic diet formula according to claim 4, wherein the vitamin A is added in an amount of 0 to 12.00 micrograms per vitamin gram of the ketogenic diet formula, and the vitamin D is in the range of 0 to 300 IU. It is 0-0.01 mg, riboflavin is 0-0.07 mg, niacin is 0-0.05 mg, vitamin C is 0-0.5 mg, vitamin E 0 to 0.11 mg, biotin 0 to 0.3 μg, pantothenic acid 0 to 0.1 mg, folic acid 0 to 4 μg, vitamin B12 0 to 0.09 μg.
The preparation method of the ketogenic diet formula according to claim 4, wherein the calcium ketone diet formula comprises 0 to 50.00 mg of calcium, 0 to 30.00 mg of phosphorus, and 0 of sodium. ~20.00 mg, magnesium is 0-5.0 mg, iron is 0-0.10 mg, zinc is 0-0.20 mg, selenium is 0-0.80 μg, copper is 0-0.01 mg, manganese is 0-0.015 mg, and potassium is 0- 50 mg, chlorine is 0-0.15 mg, iodine is 0-1.5 micrograms, chromium is 0-0.15 micrograms, and molybdenum is 0-0.15 micrograms.
The preparation method of the ketogenic diet formula according to claim 4, wherein the ketone diet formula comprises 0 to 2.5 mg of proline and 0 to 3.5 mg of methionine per 100 g of the formula. Leucine is 0-2.5 mg, phenylalanine is 0-2 mg, leucine is 0-4 mg, tryptophan is 0-1 mg, threonine is 0-2 mg, and lysine is 0 to 3 mg, histidine is 0 to 3 mg, cysteine is 0 to 3.5 mg, tyrosine is 0 to 1.5 mg, and arginine is 0 to 30 mg.
The preparation method of the ketogenic diet formula according to claim 4, characterized in that the pure lean pork, beef, lean poultry meat, lean fish meat or shrimp meat is cleaned and cut into pieces having a size of 2 cm × 2 cm × 2 cm. It is cooked at 105-110 ° C for 50-60 minutes. After cooling with cold water to room temperature, the centrifuge is dehydrated to a water content of not more than 20%, and vacuum dehydrated at 0.05 MPa, 20 ° C for 2 hours. , to the mass water content of not more than 1%, after smashing through 100 sieves, or cold water shower cooling to room temperature, using a colloid mill to grind to a solid particle size of not more than 0.15mm, solid content of 40 to 50%, and then Spray drying under the condition of an inlet temperature of 250 to 350 ° C to obtain a protein substance powder;

The cooked egg or tofu is slurried, vacuum dehydrated at 0.05 MPa, 20 ° C, 2 hours, to a mass water content of not more than 1%, and after pulverization, 100 sieves are obtained to obtain a protein raw material powder;

The fat meat is cleaned, cut into pieces of 2cm × 2cm × 2cm, cooked at 105 ~ 110 ° C, 50 ~ 60 minutes, cooled to room temperature by cold water, and then ground to solid by colloidal grinding. The particle size is not more than 0.15 mm, the solid content is 40-50%, and then spray-drying at an inlet temperature of 250-350 ° C to obtain a fatty substance;

The cooked egg yolk is slurried and vacuum-dehydrated at 0.05 MPa, 20 ° C for 2 hours to a mass water content of not more than 1%, and after pulverization, 100 sieves are obtained to obtain a fatty substance.
The preparation method of the ketogenic diet according to claim 4, wherein the protein raw material powder is dried, and dried by hot air, microwave drying, puffing drying or infrared drying.
The preparation method of the ketogenic diet formula according to claim 4, wherein the liquid milk is prepared according to the method of Chinese Patent No. 200810009006.X.