CN103876139B - A kind of dietary composition that is used for the treatment of self-closing disease and preparation method thereof - Google Patents

A kind of dietary composition that is used for the treatment of self-closing disease and preparation method thereof Download PDF

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CN103876139B
CN103876139B CN201410100231.XA CN201410100231A CN103876139B CN 103876139 B CN103876139 B CN 103876139B CN 201410100231 A CN201410100231 A CN 201410100231A CN 103876139 B CN103876139 B CN 103876139B
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dietary composition
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vitamin
cobastab
self
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CN103876139A (en
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黎峰
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Guangzhou friendship Biological Technology Co.,Ltd.
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GUANGZHOU CINJEP BIOTECHNOLOGY CO Ltd
GUANGZHOU KETOGENIC MEDICAL TREATMENT TECHNOLOGY Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The present invention discloses a kind of dietary composition, described composition adopts the edible vegetable oil of certain content combination, medium chain triglyceride, hydrolysis small molecular protein powder, food fibre powder, nut, egg powder, glycitols, casein sodium, single, diglycerine fatty acid ester, DHA, arachidonic acid, taurine, phosphatid ylcholine, phosphatidylserine, the compositions such as minerals and vitamins, between each component, interact, influence each other, described dietary composition can meet under the main nutrients prerequisite that autism children patient grows required by diet intervention, can promote internal metabolism to produce acetoacetate and beta-hydroxy-butanoic acid and acetone by diet intervention, can produce a series of Biochemical Effect to brain, reach the effect of therapeutic intervention self-closing disease. meanwhile, the invention also discloses preparation method and the purposes of described dietary composition.

Description

A kind of dietary composition that is used for the treatment of self-closing disease and preparation method thereof
Technical field
The present invention relates to a kind of dietary composition and preparation method thereof, especially a kind of drink that can therapeutic intervention self-closing diseaseFood composition and method of making the same.
Background technology
Autism has clear and definite medical science to define, and also claims self-closing disease, claims again autistic disorder (autisticdisorder)Deng, be the representative disease of pervasive developmental disorders (pervasivedevelopmentaldisorder, PDD). Main specialLevying is the remarkable limitation of ignoring emotion, refusal interchange, development of speech sluggishness, behavior and repeat mechanical and movable AOI,Generally before 3 years old, will show. Self-closing disease person has eyesight to be but reluctant with you to looking, and has language to be but difficult to exchange with you,Have hearing but always to turn a deaf ear to, have behavior total and your hope disagree ... people have no way of explaining, they have to be called" child of star "-just as star in the sky, one of a people world, alone flicker.
Up to the present, roughly every ten thousand children 2～13 people of illness rate report of countries in the world to self-closing disease. Men and women's morbidityHave notable difference, majority is reported as 4:1～5:1, and China is reported as 6.5:1～9:1. Evidence suggests the shadow of this disease to girlSound is comparatively serious, and has cognitive disorder family history person also more. Gender differences are the most obvious in the self-closing disease of normal IQ. ButThat, in the self-closing disease patient of utmost point severe feeblemindedness, M-F is close.
The diagnosis of self-closing disease and assessment quantification are mainly with the relevant scale of self-closing disease, and the relevant scale of self-closing disease mainly contains: self-closingDisease behavior rating scale (ABC), autism of children measuring scale (CARS), self-closing disease diagnostic observation scale (ADOS-G) and self-closing disease are examinedDisconnected interview scale revised edition (ADI-R) etc. Childhood autism measuring scale (thechildhooclautismratingScaie, CARS) worked out in 1980 by E.Schopler.R.J.Reichler and B.R.Renner, be that use is the widest at presentOne of autism test scale, is applicable to more than 2 years old children. CARS reliability, validity are better, can not only distinguish retarded and lonelyDisease, also can be judged autistic light and heavy degree, therefore has larger applicability. In clinical manipulation, appraiserShould by direct observation, with head of a family's interview, analyze the various ways data collections such as existing medical history record, on basis, remake since thenGo out evaluation. CARS comprises 15 evaluation projects. Each project is all attached with explanation, points out key check points, allows evaluation person have unificationObservation emphasis and method of operating. Scale is by 1,2,3,4 level Four standards of grading. Every grade of scoring is followed successively by " suitable with the ageBehavior performance ", " mile abnormality ", " moderate is abnormal ", " severely subnormal ". Every one-level scoring has concrete descriptive explanation. ShouldScale is specific as follows:
In prior art, the treatment means of self-closing disease mainly contain: 1, the traditional Chinese medical science (acupuncture, Chinese medicine etc.) treatment, take effect slowly, and canPoor repeatability, is difficult to allow autism children accept and adhere to; 2, Western medicine (central excitation agent medicine, anti-depression drug, neural rawThe long factor etc.) treatment, side effect is obvious, and necessary long-term taking, can become more serious once stop the state of an illness. Long-term use,Except causing childhood dystrophy, affect bone growth and growth and development, also the hyperactivity of original possibility self-healing can be developedBecome the continuity spiritual foul disease in all one's life; 3, psychological intervention, Rehabilitation Training in Treating, symptom for the moment is just alleviated in psychotherapy, bides one's timeBetween one long, the state of an illness still can rebound, and needs long-term treatment, and it is slow to take effect. At present, the charge of China's psychotherapy self-closing disease relativelyHeight, general family still can not afford.
To sum up, self-closing disease does not have highly effective treatment means at present, therefore develop a kind of diet combination of special formulationThing and utilize said composition therapeutic intervention autism of children, tool is of great significance.
Summary of the invention
The object of the invention is to overcome above-mentioned the deficiencies in the prior art part and provide a kind of for therapeutic intervention childrenThe dietary composition of self-closing disease; Meanwhile, the present invention also provides the preparation method of described dietary composition and has treated in preparationPurposes in the pharmaceutical composition of self-closing disease.
For achieving the above object, the technical scheme that the present invention takes is: a kind of dietary composition, described composition comprise withThe component of lower weight portion: 20～25 parts of edible vegetable oils, 10～20 parts of medium chain triglycerides, hydrolysis small molecular protein powder 15～20Part, 20～35 parts of food fibre powders, 5～15 parts of nuts, 5～10 parts of egg powders, 10～20 parts of glycitols, casein sodium 1～3 parts, single, 2～4 parts of diglycerine fatty acid esters, 0.075～0.15 part of DHA, arachidonic acid 0.03～0.07 part, 0.11～0.14 part of taurine, 0.6～1.4 part of phosphatid ylcholine, 0.25～0.4 part of phosphatidylserine, sodium 0.2～0.6 part, 0.3～0.8 part, potassium, 0.6～1.5 part of calcium, 0.13～0.21 part, magnesium, 0.0095～0.022 part of iron, zinc 0.006～0.018 part, 0.0004～0.0017 part of vitamin A, 0.00001～0.00002 part of vitamin D, vitamin E 0.0076～0.018 part, 0.1～0.225 part of vitamin C, Cobastab10.0009～0.0022 part, Cobastab20.0009～0.0022 part,0.011～0.033 part of niacinamide, Cobastab60.0007～0.0022 part, 0.0002～0.0006 part, folic acid, vitaminB120.0022～0.008 part of 0.000001～0.0000066 part, pantothenic acid.
Present inventor finds by large quantity research, when adopting in the composition of formula described above, between each componentInteract, influence each other, described composition can meet the autism children patient required main battalion of growing by diet interventionSupport element, the more important thing is, promote internal metabolism to produce acetoacetate and beta-hydroxy-butanoic acid and acetone by diet intervention, can be rightBrain produces a series of Biochemical Effect, reaches the effect of therapeutic intervention self-closing disease.
Dietary composition of the present invention, can directly eat, or brew by warm water rear edible, can also be with commonEdible after food cooking.
As the preferred embodiment of dietary composition of the present invention, described edible vegetable oil be soybean oil, palm oil,At least one in corn oil, olive oil, walnut oil.
As the preferred embodiment of dietary composition of the present invention, described hydrolysis small molecular protein powder is soybean, jadeAt least one in rice, Egg-white, fish albumen.
As the preferred embodiment of dietary composition of the present invention, described hydrolysis small molecular protein powder adopts with belowMethod is prepared from: by adding acidity regulator in food protein, is mixed with solution, regulates pH to 6.5～7.5, and insulation 35～37 DEG C, add compound protease, hydrolysis, 105 DEG C of sterilizings, the enzyme that goes out, spraying is dry, must be hydrolyzed small molecular protein powder.
As the preferred embodiment of dietary composition of the present invention, described nut is in pine nut, walnut, almondAt least one.
As the preferred embodiment of dietary composition of the present invention, described glycitols be maltitol, antierythrite,At least one in isomalt.
In addition, the present invention also provides a kind of preparation method of dietary composition described above, for realizing this object, the present inventionThe technological means of taking is: a kind of preparation method of dietary composition described above, said method comprising the steps of:
(1) by edible vegetable oil, medium chain triglyceride, egg powder, hydrolysis small molecular protein powder, food fibre powder, sugar alcoholClass, phosphatid ylcholine, DHA, arachidonic acid, phosphatidylserine, casein sodium, list, diglycerol fatAcid esters mixes, the stirring that adds water, and emulsifying, spraying is dry, obtains semi-finished product A;
(2) by sodium, potassium, calcium, magnesium, iron, zinc, vitamin A, vitamin D, vitamin E, vitamin C, Cobastab1, support one's familyElement B2, niacinamide, Cobastab6, folic acid, Cobastab12, pantothenic acid and taurine mix, and obtains semi-finished product B;
(3) semi-finished product A, semi-finished product B and nut are mixed, obtain dietary composition.
In step described above (1), the semi-finished product A obtaining can be powder, or adds appropriate water after making powder againBe mixed and made into bulk.
Finally, the present invention also provides the purposes of dietary composition described above in the medicine of preparation treatment self-closing disease.Dietary composition of the present invention, when edible, direct-edible, or brew rear ediblely by warm water, or cook with common foodRear edible; While eating with common food culinary art is rear, eat every days 4～5, according to all ages and classes section crowd energy intake meterCalculate, amount must meet all ages and classes section crowd needs that grow with protein and be as the criterion. When edible, note fat: (albumenMatter+carbohydrate)=0.5～3:1, and also every day, carbohydrate was taken in total amount≤30 gram.
Dietary composition of the present invention mainly for 1～13 years old without major disease history (congenital heart disease, leukaemia),Without metabolic disease (fat oxidation defect, ketoplasia/decomposition defect, pyruvate carboxylase deficiency, serious liver diseases,Some mitochondriopathy), be evaluated as the slightly patient of above self-closing disease through CARS scale.
Dietary composition of the present invention, adopts the composition of special formulation to combine, through practical proof, and described dietComposition is meeting under the prerequisite of autism children nutritional need, effectively therapeutic intervention self-closing disease, and can not produceAny side effect. When edible, can be rear edible with common food culinary art, be relatively easy to allow autism children accept and adhere to, becomeThis is lower, and effect is better. The preparation method of dietary composition of the present invention, simple and convenient, can be fast and effectively forPrepare dietary composition. The purposes of dietary composition of the present invention, for the treatment of self-closing disease provides another kind of possible wayFootpath, tool is of great significance.
Detailed description of the invention
For better explanation the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present inventionBe described further.
Embodiment 1
The present invention is used for the treatment of a kind of embodiment of the dietary composition of self-closing disease, dietary composition bag described in the present embodimentComponent containing following weight portion: 20 parts of edible vegetable oils, 20 parts of medium chain triglycerides, 15 parts, hydrolysis small molecular protein powder, meals35 parts of fiber powders, 5 parts of nuts, 10 parts of egg powders, 20 parts of glycitols, 1 part of casein sodium, single, diglycerine fatty acid ester 2Part, 0.075 part of DHA, 0.07 part of arachidonic acid, 0.11 part of taurine, 1.4 parts of phosphatid ylcholines, phosphatidyl0.25 part of serine, 0.6 part, sodium, 0.3 part, potassium, 1.5 parts of calcium, 0.13 part, magnesium, 0.022 part of iron, 0.018 part, zinc, vitaminA0.0004 part, 0.00001 part of vitamin D, 0.018 part of vitamin E, 0.1 part of vitamin C, Cobastab10.0022 part, support one's familyElement B20.0009 part, 0.011 part of niacinamide, Cobastab60.0022 part, 0.0006 part, folic acid, Cobastab120.000001 part,0.0022 part, pantothenic acid; Described edible vegetable oil adopts soybean oil, described hydrolysis small molecular protein powder to adopt zein, described mealsIt is antierythrite that food fiber powder adopts oligoisomaltose, described nut to adopt almond, described glycitols.
Described in the present embodiment, dietary composition adopts following methods to be prepared from:
(1) by edible vegetable oil, medium chain triglyceride, egg powder, hydrolysis small molecular protein powder, food fibre powder, sugar alcoholClass, phosphatid ylcholine, DHA, arachidonic acid, phosphatidylserine, casein sodium, list, diglycerol fatAcid esters mixes, the stirring that adds water, and emulsifying, spraying is dry, obtains semi-finished product A;
(2) by sodium, potassium, calcium, magnesium, iron, zinc, vitamin A, vitamin D, vitamin E, vitamin C, Cobastab1, support one's familyElement B2, niacinamide, Cobastab6, folic acid, Cobastab12, pantothenic acid and taurine mix, and obtains semi-finished product B;
(3) semi-finished product A, semi-finished product B and nut are mixed, obtain dietary composition.
Embodiment 2
The present invention is used for the treatment of a kind of embodiment of the dietary composition of self-closing disease, dietary composition bag described in the present embodimentComponent containing following weight portion: 25 parts of edible vegetable oils, 10 parts of medium chain triglycerides, 20 parts, hydrolysis small molecular protein powder, meals20 parts of fiber powders, 15 parts of nuts, 5 parts of egg powders, 10 parts of glycitols, 3 parts of casein sodiums, single, diglycerine fatty acid ester 4Part, 0.15 part of DHA, 0.03 part of arachidonic acid, 0.14 part of taurine, 0.6 part of phosphatid ylcholine, phosphatidyl0.4 part of serine, 0.2 part, sodium, 0.8 part, potassium, 0.6 part of calcium, 0.21 part, magnesium, 0.0095 part of iron, 0.006 part, zinc, vitaminA0.0017 part, 0.00002 part of vitamin D, 0.0076 part of vitamin E, 0.225 part of vitamin C, Cobastab10.0009 part, dimensionRaw plain B20.0022 part, 0.033 part of niacinamide, Cobastab60.0007 part, 0.0002 part, folic acid, Cobastab120.00000660.008 part, part, pantothenic acid; Described edible oil is that the mixture of corn oil and olive oil, described hydrolysis small molecular protein powder are soybeanWith the mixture of Egg-white, described food fibre powder be that the mixture of wheat and konjaku powder, described nut are pine nut and coreThe mixture of peach, described glycitols are the mixture of maltitol and isomalt.
Described in the present embodiment, dietary composition adopts and is prepared from the method for embodiment 1.
Embodiment 3
The present invention is used for the treatment of a kind of embodiment of the dietary composition of self-closing disease, dietary composition bag described in the present embodimentComponent containing following weight portion: 22 parts of edible vegetable oils, 15 parts of medium chain triglycerides, 16 parts, hydrolysis small molecular protein powder, meals25 parts of fiber powders, 10 parts of nuts, 6 parts of egg powders, 12 parts of glycitols, 2 parts of casein sodiums, single, diglycerine fatty acid ester 3Part, 0.1 part of DHA, 0.05 part of arachidonic acid, 0.12 part of taurine, 0.8 part of phosphatid ylcholine, phosphatidyl silk0.3 part of propylhomoserin, 0.3 part, sodium, 0.5 part, potassium, 1.0 parts of calcium, 0.15 part, magnesium, 0.01 part of iron, 0.01 part, zinc, 0.0008 part of vitamin A,0.000012 part of vitamin D, 0.01 part of vitamin E, 0.15 part of vitamin C, Cobastab10.001 part, Cobastab20.0015Part, 0.02 part of niacinamide, Cobastab60.001 part, 0.0004 part, folic acid, Cobastab120.004 part of 0.000002 part, pantothenic acid;Described edible oil be the mixture of palm oil, corn oil and walnut oil, described hydrolysis small molecular protein powder be corn, Egg-white andThe mixture of fish albumen, described food fibre powder be the mixture of soybean, oranges and tangerines and guar gum, described nut be pine nut,The mixture of walnut and almond, described glycitols are the mixture of maltitol, antierythrite and isomalt.
Described in the present embodiment, dietary composition adopts and is prepared from the method for embodiment 1.
Embodiment 4
The present invention is used for the treatment of a kind of embodiment of the dietary composition of self-closing disease, dietary composition bag described in the present embodimentComponent containing following weight portion: 24 parts of edible vegetable oils, 18 parts of medium chain triglycerides, 18 parts, hydrolysis small molecular protein powder, meals30 parts of fiber powders, 12 parts of nuts, 8 parts of egg powders, 16 parts of glycitols, 2 parts of casein sodiums, single, diglycerine fatty acid ester 3Part, 0.12 part of DHA, 0.06 part of arachidonic acid, 0.13 part of taurine, 1.0 parts of phosphatid ylcholines, phosphatidyl0.35 part of serine, 0.5 part, sodium, 0.6 part, potassium, 1.2 parts of calcium, 0.2 part, magnesium, 0.02 part of iron, 0.015 part, zinc, vitamin A 0.001Part, 0.000015 part of vitamin D, 0.015 part of vitamin E, 0.2 part of vitamin C, Cobastab10.0015 part, vitaminB20.002 part, 0.03 part of niacinamide, Cobastab60.002 part, 0.0005 part, folic acid, Cobastab120.000005 part, pantothenic acid0.006 part; Described edible oil be walnut oil, the described hydrolysis small molecular protein powder mixture that is Egg-white and fish albumen, described inFood fibre powder is that the mixture of konjaku powder and guar gum, described nut are the mixture of walnut and almond, described sugarAlcohols is the mixture of maltitol and antierythrite.
Described in the present embodiment, dietary composition adopts and is prepared from the method for embodiment 1.
Embodiment 5 dietary composition of the present invention is for the effect experiment of therapeutic intervention self-closing disease
The dietary composition that adopts the embodiment of the present invention 1 to prepare. Experimental subjects is Lee * *, sex man, age: two years old08 months. Eating method is rear edible for adopting warm water to brew, and treatment meal every days phase 4～5, eats diet group of the present invention every dayAltogether 200g of compound, adheres to 4 weeks, the adjustment period of then entering, adjustment period every days 4～5 meal, every day edible dietary composition of the present invention altogether100g, adheres to 2 weeks, reenters subsequently the treatment phase; Experiment is carried out 24 weeks continuously, before adopting CARS Measuring scale assessing edible, edibleProcess and edible after situation, result is as shown in table 1.
Table 1 childhood autism (self-closing disease) measuring scale (CARS) result
In edible process, observation experiment object, finds: before edible, patient, except once in a while little sound is " Papa and Mama ", does not haveThere are other any speeches, only like the object of linear, other toys in face of ignoring. CARS scale is 37 points, belongs to moderate orphanSolely disease (self-closing disease). Edible after the 2nd week, patient than in the past more naughty, occur that more behavior exchanges, master when having a mealMove and want dish, require father and mother to feed to oneself. Edible after the 3rd week, patient father and mother with other toys for example, linear object (rope chopsticksSon and so on) replace, patient can not resist. There are the hopes of wanting representation language and emotion in patient, and do not become estranged him morePeople. Edible after the 6th week, 34 points of CARS scale repetition measurement scores, have had certain improvement. Edible after the 12nd week, patient starts oneA little simple words (for example have a meal, sleep, goes to toilet etc.). 27 points of CARS scale repetition measurement scores, are continuing improvement. The edible the 24thZhou Hou, patient understands correction happiness, loses and indignation. 24 points of CARS scale repetition measurement scores, have obtained larger improvement, although intelligenceForce rate child of the same age has backwardness to a certain degree, but has had the possibility that enters common kindergarten.
Embodiment 6 dietary composition of the present invention is for the effect experiment of therapeutic intervention self-closing disease
The dietary composition that adopts the embodiment of the present invention 2 to prepare. Experimental subjects is king * *, sex man, age: four years old05 months. Eating method is directly edible, treatment meal every days phase 4～5, edible dietary composition of the present invention every day 240g altogether, heavily fortified pointHold 4 weeks, the adjustment period of then entering, adjustment period every days 4～5 meal, edible dietary composition of the present invention every day 120g altogether, adheres to 2 weeks,Reenter subsequently the treatment phase. Experiment is carried out 24 weeks continuously, before adopting CARS Measuring scale assessing edible, edible process and edible afterSituation, result is as shown in table 2.
Table 2 childhood autism (self-closing disease) measuring scale (CARS) result
In edible process, observation experiment object, finds: before edible, how moving patient is, likes holding thing (as dolly, clothingFrame) the crazy race of turn-taking, cannot stop. Emotional responses is indifferent, without communication, but can understand simple word. CARS scale is 43Point, belong to severe autism (self-closing disease). Edible after the 2nd week, patient's diet becomes smoothly and rule, can eat very amusedlyComplete. Edible after the 3rd week, patient father and mother reflect that child " optimistic ", and starting has abundant emotional expression. After diet the 6th week, CARS40 points of scale repetition measurement scores. Child starts there is pronunciation, can unconsciously cry " father ". Edible after the 12nd week, the head of a family reflect than withBefore " well-behaved ", quiet, how moving behavior obviously reduces. Can undisturbedly play. 36 points of CARS scale repetition measurement scores, are continuingImprove. Edible after the 24th week, the overall self-closing disease situation of patient has good improvement, and language is abundant, the guidance that can accept adult.33 points of CARS scale repetition measurement scores. Patient's situation is greatly improved, and the problem of communication and behavior aspect is improved the most obvious,For child adapts to society, and certain basis has been laid in other people suitable communication.
Embodiment 7 dietary composition of the present invention is for the effect experiment of therapeutic intervention self-closing disease
This experiment is selected self-closing disease patient 110 examples according to CCMD-3 diagnostic criteria, wherein male 72 examples, female's 38 examples, and the age 1～10 years old, the mean age was 6.33 ± 1.38 years old. Be 24 weeks experimental period.
Eating method is: edible dietary composition of the present invention, when edible, be divided into the treatment phase and adjustment period, treatment every day phase 4～5 meal, within 1～3 years old, patient eats dietary composition 180～210g of the present invention every day altogether, and within 4～6 years old, patient eats this every day altogetherBright dietary composition 220～260g, 7～10 years old patient's every day, edible dietary composition 270～320g of the present invention altogether, adhered to 4 weeks,Then the adjustment period of entering; Adjustment period every days 4～5 meal, 1～3 years old patient's every day edible dietary composition 90～105g of the present invention altogether,Within 4～6 years old, patient eats dietary composition 110～130g of the present invention every day altogether, and within 7～10 years old, patient eats diet of the present invention every day altogetherComposition 135～160g, adheres to 2 weeks, reenters subsequently the treatment phase. It is as follows that take in Energy distribution every day treatment phase: 77% energyAmount source fat (medium chain fatty acid 27%, LCFA 50%), 14% is protein, 9% is carbohydrate, adhere to 4 weeks, withAfter enter adjustment period. Adjustment period to take in Energy distribution as follows every day: 50% energy source fat, protein is not limit, carbon hydrateThing is taken in to limit and is no more than 35g every day, adheres to 2 weeks, reenters subsequently the treatment phase. Experiment is carried out 24 weeks continuously. Diet carries outDuring this time, children follow up a case by regular visits to 24 weeks, within 7 weeks, do a spirit inspection, as an evaluation criteria. According to childhood autism measuring scale,Child is carried out to each spirit inspection. The raw score of Measuring scale assessing and the difference of following up a case by regular visits between mark are taked t inspection pairingRelatively.
23 examples can not be adhered to one month, and other 14 examples adhere to stopping after 4-8 week. Residue is adhered to the 73 routine patients that eatIn, according to childhood autism evaluation form, record is all improved before showing all self-closing disease behaviors. Wherein 23 patients have heavilyImprove greatly that (CARS reduce > 12 points), 19 patients have moderate to improve (CARS reduces 8-12 and divides), 31 patients have slight improvement(CARS reduces by 8 points of <). Hence one can see that, and dietary composition of the present invention can be effective to intervene and treatment self-closing disease.
The last above embodiment that it should be noted that of institute is only in order to technical scheme of the present invention to be described but not the present invention is protectedProtect the restriction of scope, although the present invention is explained in detail with reference to preferred embodiment, those of ordinary skill in the art shouldUnderstand, can modify or be equal to replacement technical scheme of the present invention, and not depart from the essence of technical solution of the present inventionAnd scope.

Claims (3)

1. a dietary composition, is characterized in that, described composition is made up of the component of following weight portion: edible vegetable oil 20～25 parts, 10～20 parts of medium chain triglycerides, 15～20 parts, hydrolysis small molecular protein powder, 20～35 parts of food fibre powders, nut5～15 parts of benevolence, 5～10 parts of egg powders, 10～20 parts of glycitols, 1～3 part of casein sodium, single, diglycerine fatty acid ester 2～4Part, 0.075～0.15 part of DHA, 0.03～0.07 part of arachidonic acid, 0.11～0.14 part of taurine, phosphatide0.6～1.4 part of phatidylcholine, 0.25～0.4 part of phosphatidylserine, 0.2～0.6 part, sodium, 0.3～0.8 part, potassium, calcium 0.6～1.5Part, 0.13～0.21 part, magnesium, 0.0095～0.022 part of iron, 0.006～0.018 part, zinc, 0.0004～0.0017 part of vitamin A,0.00001～0.00002 part of vitamin D, 0.0076～0.018 part of vitamin E, 0.1～0.225 part of vitamin C, vitaminB10.0009～0.0022 part, Cobastab20.0009～0.0022 part, 0.011～0.033 part of niacinamide, vitaminB60.0007～0.0022 part, 0.0002～0.0006 part, folic acid, Cobastab120.000001～0.0000066 part, pantothenic acid0.0022～0.008 part;
Described edible vegetable oil is at least one in soybean oil, palm oil, corn oil, olive oil, walnut oil;
Described hydrolysis small molecular protein powder is at least one in soybean, corn, Egg-white, fish albumen;
Described hydrolysis small molecular protein powder adopts following methods to be prepared from: by adding acidity regulator in food protein, joinMake solution, regulate pH to 6.5～7.5, be incubated 35～37 DEG C, add compound protease, hydrolysis, 105 DEG C of sterilizings, the enzyme that goes out, sprayMist is dry, must be hydrolyzed small molecular protein powder;
Described nut is at least one in pine nut, walnut, almond;
Described glycitols is at least one in maltitol, antierythrite, isomalt.
2. a preparation method for dietary composition as claimed in claim 1, is characterized in that, described method comprises following stepRapid:
(1) by edible vegetable oil, medium chain triglyceride, egg powder, hydrolysis small molecular protein powder, food fibre powder, glycitols, phosphorusAcyl choline, DHA, arachidonic acid, phosphatidylserine, casein sodium, list, diglycerine fatty acid esterMix, the stirring that adds water, emulsifying, spraying is dry, obtains semi-finished product A;
(2) by sodium, potassium, calcium, magnesium, iron, zinc, vitamin A, vitamin D, vitamin E, vitamin C, Cobastab1, Cobastab2、Niacinamide, Cobastab6, folic acid, Cobastab12, pantothenic acid and taurine mix, and obtains semi-finished product B;
(3) semi-finished product A, semi-finished product B and nut are mixed, obtain dietary composition.
3. the purposes of dietary composition in the medicine of preparation treatment self-closing disease as claimed in claim 1.
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