CN101269210A - Ketogenic mix preparation suitable for treating intractable epilepsy - Google Patents
Ketogenic mix preparation suitable for treating intractable epilepsy Download PDFInfo
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- CN101269210A CN101269210A CNA2008100280454A CN200810028045A CN101269210A CN 101269210 A CN101269210 A CN 101269210A CN A2008100280454 A CNA2008100280454 A CN A2008100280454A CN 200810028045 A CN200810028045 A CN 200810028045A CN 101269210 A CN101269210 A CN 101269210A
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Abstract
The invention relate to a ketogenesis mixture preparation applicable for treating refractory epilepsy, which is characterized in that: (1) fat, protein and carbohydrate form the basic prescription, a small amount of essential vitamins, minerals and aminophenol promoting the growth and the development of the human body and brain and promoting the metabolism are added in the basic prescription; (2) in the basic preparation, the weight percentages of the components are respectively that: fat 70-80 percent, protein 15-20 percent, carbohydrate 5-10 percent; (3) the physical states of all the components in the basic preparation are powder, ointment, aqua, or solid state agent. The physical states of the ketogenesis mixture preparation are powder granule, electuary, liquid agent, tablet, capsule or other solid state agent. The ketogenesis mixture preparation aims at the special nutrition requirement of Chinese, nutritional ingredient promoting the development of the brain and the metabolism is added in, the curative efficiency on refractory epilepsy reaches 80 percent, which reaches or exceeds the curative effect of the equivalent product abroad.
Description
Technical field
The present invention relates to the living ketone mix preparation of the intractable epilepsy of a kind of suitable treatment, the living ketone mix preparation of the intractable epilepsy of the Chinese treatment of particularly suitable.Belong to the Special food technical field.
Background technology
At present, there is epileptic 6,000,000 in China, and wherein 25% is the refractory epilepsy.Generally believe in the world at present novel antuepileptic only to the intractable epilepsy child of 30-40% to effectively (outbreak reduces more than 50%); And high fat diet to the intractable epilepsy child of 50-80% to effectively, 30% child can reduce by 90% outbreak, the patient of 10-20% is control of seizures fully.Obviously the high fat diet therapy is more effective than novel antuepileptic.
High fat diet (ketogenic diet) is a high fat, low-carb, suitable proteinic special diet therapy.Its existing abroad history that was applied to the epileptic in 70 years that surpasses, curative effect that it is definite and safety have become one of conventional therapy means of the intractable epilepsy of a plurality of foreign treatments, and write already in many epilepsy textbooks of external classics.
Because the specific implementation process of high fat diet will remain the ratio that keeps fat and carbohydrate+protein mixture in the diet for a long time, therefore the patient is difficult to allocate voluntarily, especially to the adult patient of young infant patient with the mental retardation of no special messenger's treatment, more be difficult to carry out, promptly be difficult to adopt the eating method of common food.Nutritional labeling just because of various food is difficult to estimation, and the influence of X factor in the common feed usually is to cause the treatment failure.Therefore, the external existing marketization, with the bread and cheese powderization, and in this ratio deployed the product mix supply.Yet, because Chinese nutritious food custom is with different abroad, the requirement of trace element such as various vitamin and mineral for this reason, need find a kind of high fat diet therapy of specially at Chinese treatment treating intractable epilepsy also with different abroad.
Summary of the invention
Purpose of the present invention is for the living ketone mix preparation (comprising powder, unguentum and solid-state agent, liquid agent) of the intractable epilepsy of a kind of suitable treatment is provided, and has extensively to be suitable for Chinese colony, characteristics evident in efficacy.
Purpose of the present invention can reach by taking following measure:
Be suitable for the living ketone mix preparation of the intractable epilepsy of treatment, it is characterized in that:
1) forms basic recipe by fat, protein and carbohydrate, in basic recipe, add capacity needed by human vitamin, mineral and promotion human body and brain growth promoter and promote lipometabolic aminoacid;
2) in basic recipe, the quality percentage composition of each component is respectively: fatty 65-80%, protein 15-25%, carbohydrate 5-15%;
3) state of matter of each component is powder, unguentum, liquid agent or solid-state agent in the basic recipe.
Purpose of the present invention can also reach by taking following measure:
One embodiment of the present invention are: the vitamin that is added comprises one of vitamin A, vitamin D, vitamin E, vitamin C, vitamin K, vitamin B1, riboflavin, vitamin B6, vitamin B12, biotin, vitamin B complex, nicotinic acid or nicotinic acid equivalent, folic acid, pantothenic acid and inositol (inosite, inositol).
One embodiment of the present invention are: the mineral that is added comprises sodium, potassium, chlorine, calcium, phosphorus, magnesium, ferrum, copper, zinc, manganese, iodine, molybdenum, selenium and chromium.
One embodiment of the present invention are: the promotion human body of described interpolation and brain growth promoter and the lipometabolic aminoacid of promotion comprise L-lysine, taurine and L-carnitine.
One embodiment of the present invention are: the state of matter of giving birth to the ketone mix preparation is powder, unguentum, liquid agent or solid-state agent.
The present invention has following outstanding beneficial effect:
1, the present invention designs at the special nutritional need of Chinese specially, and has added promotion brain development and lipometabolic nutritional labeling.Expection reaches 80% to intractable treatment of epilepsy effective percentage, meets or exceeds the curative effect of external like product.
2, the present invention is a kind of mix preparation, and has added simultaneously and obtain the promotion brain development and the lipometabolic trophic factors that medical circle is generally acknowledged at present, and expection can meet or exceed the curative effect of external like product, plays the effect of import substitutes.
The specific embodiment
The specific embodiment 1:
The feature of present embodiment is: form basic recipe by fat, protein and carbohydrate, add capacity needed by human vitamin, mineral and promotion human body and brain growth promoter and promote lipometabolic aminoacid in basic recipe; The state of matter of each component is powder, unguentum, water preparation or solid-state agent in the basic recipe.
Basic recipe component and quality percentage composition thereof are as shown in table 1 in the living ketone mix preparation.
Table 1:
| Nutritional information | Content among every 100g |
| Energy (Kcal) | 800kcal |
| Albumen (g) | 15 |
| Carbohydrate (g) | 5 |
| Fat (g) | 80 |
| Fat: albumen+carbohydrate | 4∶1 |
Give birth to a small amount of needed by human vitamin, mineral and promotion human body and the brain growth promoter that is added in the ketone mix preparation and promote that lipometabolic aminoacid is as shown in table 2.
Table 2:
| Substance | Content among every 100g |
| Vitamin A μ g RE | 380μg |
| Vitamin D ug | 4ug |
| Vitamin E mg | 5mg |
| Vitamin C mg | 45mg |
| Vitamin K μ g | 30ug |
| Vitamin B1 mg | 0.6mg |
| Riboflavin mg | 0.6mg |
| Vitamin B6 mg | 0.6mg |
| Vitamin B12 μ g | 0.8ug |
| Biotin μ g | 10ug |
| The choline choline or. The vitamin B complex itOne mg | 150mg |
| Inositol orInositol, inosite, inositol mg | 30mg |
| Nicotinic acid mg or Nicotinic acid equivalent mg NE | 6mg |
| Folic acid μ g | 120ug |
| Pantothenic acid mg | 2mg |
| L-lysine | 50mg |
| L-carnitine | 150mg |
| Taurine | 40mg |
| Sodium mg | 500mg |
| Potassium mg | 700mg |
| Chlorine mg | 700mg |
| Calcium mg | 500mg |
| Phosphorus mg | 400mg |
| Magnesium mg | 110mg |
| Ferrum mg | 8mg |
| Copper mg | 0.6mg |
| Zinc mg | 8mg |
| Manganese mg | 0.65mg |
| Iodine ug | 70ug |
| Molybdenum ug | 15ug |
| Selenium ug | 20ug |
| Chromium ug | 15ug |
The clinical practice of this enforcement:
Be applicable to following situation:
(1) intractable epilepsy: fail to respond to any medical treatment through 1-2 kind above one or two wires antuepileptic, and can't perform the operation.
(2) glucose transporter deficiency disease (GLUT1).
(3) pyruvic dehydrogenase deficiency (PDH).
Press all ages and classes and body weight and calculate, the patient 10-15g/kg/d that takes food every day.Need not add other any foods.
For example the patient is 2 years old, body weight 10kg,, take this food 125g every day, divide breakfast, lunch and dinner to take, the physiological need amount be can satisfy, and epilepsy disappearance or minimizing reached.
The ratio of fat and carbohydrate and protein sum was near 4: 1 in the present embodiment.Owing to added an amount of kind mineral, vitamin and aminoacid (addition and Chinese physiological need amount are in full accord) according to Chinese constitutive character, made Chinese patient's curative effect splendid.Wherein:
L-lysine: lysine is one of essential amino acid, can promote human development, raise immunity, and people's nervus centralis and peripheral nervous system all played an important role.Human body can not self synthesize L-lysine, must draw from food.Human body has only and has replenished absorption and the utilization that enough L-lysine could improve food protein, reaches balanced nutritious, promotes growth promoter.
L-carnitine (L-Carnitine): be the necessary key substance of fatty physiological oxidation.Especially in the metabolism that utilizes fat as energy source, play an important role.
Taurine: claim the alpha-amido ethyl sulfonic acid again, the earliest by separating in the Calculus Bovis, so gain the name.Taurine in the main dependence pickuping food satisfies the body needs.It has the infant brain tissue of promotion and intelligence development, improves nerve conduction and visual function, improves memory, improves endocrinosity, strengthens the function of human immunity.Especially has the function that suppresses and regulate the neurotransmitter in the brain.Research report shows that the taurine supplement has multiple efficacies to epilepsy, and it helps to stablize the cell membrane of overacfivity, thereby extremely important to the control of epilepsy.Natural taurine disperses, amount is few, far can not satisfy people's needs.
Specific embodiment 2:
The characteristics of present embodiment are: the promotion human body of described interpolation and brain growth promoter and the lipometabolic aminoacid of promotion comprise L-lysine, L-carnitine and taurine.
Other specific embodiment:
In basic recipe, the quality percentage composition of each component is respectively: fat is regulated in the scope of 65-80%, and protein is regulated in the scope of 15-25%, and carbohydrate is regulated in the scope of 5-15%; Prerequisite is to guarantee fat: protein+carbohydrate=4: 1 or 3: 1.
The vitamin that is added comprises: per 100 grams are given birth in the ketone mix preparation and are contained one of vitamin A 380 μ g ± 50 μ g, vitamin D 4ug ± 0.5 μ g, vitamin E 5mg ± 0.5mg, vitamin C 45mg ± 5mg, vitamin K 30 ± 2ug, vitamin B1 0.6mg ± 0.05mg, riboflavin 0.6mg ± 0.05mg, vitamin B6 0.6mg ± 0.05mg, vitamin B12 0.8ug ± 0.05ug, biotin 10ug ± 1.5ug, vitamin B complex 150mg ± 15mg, inositol (inosite, inositol) 30mg ± 5mg.
The mineral that is added comprises: per 100 grams are given birth in the ketone mix preparation and are contained sodium 500mg ± 50mg, potassium 700mg ± 70mg, chlorine 700mg ± 70mg, calcium 500mg ± 50mg, phosphorus 400mg ± 40mg, magnesium 110mg ± 11mg, ferrum 8mg ± 0.8mg, copper 0.6mg ± 0.06mg, zinc 8mg ± 0.8mg, manganese 0.65mg ± 0.06mg, iodine 70ug ± 7ug, molybdenum 15ug ± 1.5ug, selenium 20ug ± 2ug, chromium 15ug ± 1.5ug;
The aminoacid that is added comprises: per 100 grams give birth to contain in the ketone mix preparations nicotinic acid or
The nicotinic acid equivalent6mg ± 0.6mg, folic acid 120ug ± 12 ug, pantothenic acid 2mg ± 0.2mg, L-lysine 50mg ± 5mg, L-carnitine 150mg ± 15mg, taurine 40mg ± 4mg.
Each specific embodiment of the present invention can be made powdered agent, liquid formulation, tablet, other solid-state shape preparations of capsule.
In clinical practice, except being applicable to Chinese patient, can also be suitable for other various countries ethnic groups identical or close with Chinese's body constitution feature.
Claims (5)
1, be suitable for the living ketone mix preparation of the intractable epilepsy of treatment, it is characterized in that:
1) forms basic recipe by fat, protein and carbohydrate, in basic recipe, add capacity needed by human vitamin, mineral and promotion human body and brain growth promoter and promote lipometabolic aminoacid;
2) in basic recipe, the quality percentage composition of each component is respectively: fatty 65-80%, protein 15-25%, carbohydrate 5-15%;
3) state of matter of each component is powder, unguentum, liquid agent or solid-state agent in the basic recipe.
2, the living ketone mix preparation of the intractable epilepsy of suitable treatment as claimed in claim 1, it is characterized in that: the vitamin that is added comprises vitamin A, vitamin D, vitamin E, vitamin C, vitamin K, vitamin B1, riboflavin, vitamin B6, vitamin B12, biotin, vitamin B complex, nicotinic acid or nicotinic acid equivalent, folic acid, pantothenic acid and inositol, and wherein inositol can be replaced by inosite or inositol.
3, the living ketone mix preparation of the intractable epilepsy of suitable treatment as claimed in claim 1, it is characterized in that: the mineral that is added comprises sodium, potassium, chlorine, calcium, phosphorus, magnesium, ferrum, copper, zinc, manganese, iodine, molybdenum, selenium and chromium.
4, the living ketone mix preparation of the intractable epilepsy of suitable treatment as claimed in claim 1 is characterized in that: promotion human body that is added and brain growth promoter and the lipometabolic aminoacid of promotion comprise L-lysine, L-carnitine and taurine.
5, the living ketone mix preparation of the intractable epilepsy of suitable treatment as claimed in claim 1 is characterized in that: the state of matter of giving birth to the ketone mix preparation is powdered agent, unguentum, liquid agent, tablet, capsule or solid-state agent.
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| CNA2008100280454A CN101269210A (en) | 2008-05-13 | 2008-05-13 | Ketogenic mix preparation suitable for treating intractable epilepsy |
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| CNA2008100280454A CN101269210A (en) | 2008-05-13 | 2008-05-13 | Ketogenic mix preparation suitable for treating intractable epilepsy |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2258215A1 (en) * | 2009-06-04 | 2010-12-08 | Namyang Dairy Products Co., Ltd. | Composition for ketogenic diet and preparation method thereof |
| WO2014008692A1 (en) * | 2012-07-10 | 2014-01-16 | Liao Jianxiang | Ketogenic diet formula milk and preparation method thereof |
| CN107343657A (en) * | 2017-06-05 | 2017-11-14 | 深圳市捷利康生物科技有限公司 | High fat diet formula powder |
| CN107996720A (en) * | 2017-11-29 | 2018-05-08 | 山东省农业科学院农产品研究所 | A kind of raw ketone emulsion and preparation method thereof |
| CN109662268A (en) * | 2019-02-28 | 2019-04-23 | 昭远制药有限公司 | A kind of intractable epilepsy disease diet formulation and preparation method thereof |
| CN112137115A (en) * | 2020-09-25 | 2020-12-29 | 深圳市捷利康生物科技有限公司 | Ketogenic nutrition powder with immunity enhancing effect and preparation method thereof |
| CN114376228A (en) * | 2021-12-24 | 2022-04-22 | 北京康比特体育科技股份有限公司 | Formula and preparation method of ketogenic diet beverage |
-
2008
- 2008-05-13 CN CNA2008100280454A patent/CN101269210A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2258215A1 (en) * | 2009-06-04 | 2010-12-08 | Namyang Dairy Products Co., Ltd. | Composition for ketogenic diet and preparation method thereof |
| WO2014008692A1 (en) * | 2012-07-10 | 2014-01-16 | Liao Jianxiang | Ketogenic diet formula milk and preparation method thereof |
| CN107343657A (en) * | 2017-06-05 | 2017-11-14 | 深圳市捷利康生物科技有限公司 | High fat diet formula powder |
| CN107343657B (en) * | 2017-06-05 | 2021-02-26 | 深圳市捷利康生物科技有限公司 | Ketogenic diet formula powder |
| CN107996720A (en) * | 2017-11-29 | 2018-05-08 | 山东省农业科学院农产品研究所 | A kind of raw ketone emulsion and preparation method thereof |
| CN109662268A (en) * | 2019-02-28 | 2019-04-23 | 昭远制药有限公司 | A kind of intractable epilepsy disease diet formulation and preparation method thereof |
| CN112137115A (en) * | 2020-09-25 | 2020-12-29 | 深圳市捷利康生物科技有限公司 | Ketogenic nutrition powder with immunity enhancing effect and preparation method thereof |
| CN114376228A (en) * | 2021-12-24 | 2022-04-22 | 北京康比特体育科技股份有限公司 | Formula and preparation method of ketogenic diet beverage |
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Application publication date: 20080924 |