WO2013156720A3 - Procédé de raffinage du squalène produit par microalgues - Google Patents

Procédé de raffinage du squalène produit par microalgues Download PDF

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Publication number
WO2013156720A3
WO2013156720A3 PCT/FR2013/050812 FR2013050812W WO2013156720A3 WO 2013156720 A3 WO2013156720 A3 WO 2013156720A3 FR 2013050812 W FR2013050812 W FR 2013050812W WO 2013156720 A3 WO2013156720 A3 WO 2013156720A3
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WO
WIPO (PCT)
Prior art keywords
microalgae
squalene produced
refining
produced
refining squalene
Prior art date
Application number
PCT/FR2013/050812
Other languages
English (en)
Other versions
WO2013156720A2 (fr
Inventor
Philippe Looten
Samuel PATINIER
Michel Perrut
Vincent Perrut
Original Assignee
Roquette Freres
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR1253496A external-priority patent/FR2989373B1/fr
Application filed by Roquette Freres filed Critical Roquette Freres
Priority to CA2869358A priority Critical patent/CA2869358C/fr
Priority to US14/394,813 priority patent/US9346722B2/en
Priority to KR1020147028599A priority patent/KR102192410B1/ko
Priority to EP13720486.3A priority patent/EP2838630A2/fr
Priority to CN201380020310.3A priority patent/CN104245076B/zh
Priority to IN8554DEN2014 priority patent/IN2014DN08554A/en
Priority to JP2015506284A priority patent/JP6216769B2/ja
Publication of WO2013156720A2 publication Critical patent/WO2013156720A2/fr
Publication of WO2013156720A3 publication Critical patent/WO2013156720A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
    • A23L17/60—Edible seaweed
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706—Algae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706—Algae
    • A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0426—Counter-current multistage extraction towers in a vertical or sloping position
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/34—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping with one or more auxiliary substances
    • B01D3/40—Extractive distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C5/00—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms
    • C07C5/02—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by hydrogenation
    • C07C5/03—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by hydrogenation of non-aromatic carbon-to-carbon double bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C7/00—Purification; Separation; Use of additives
    • C07C7/04—Purification; Separation; Use of additives by distillation
    • C07C7/05—Purification; Separation; Use of additives by distillation with the aid of auxiliary compounds
    • C07C7/08—Purification; Separation; Use of additives by distillation with the aid of auxiliary compounds by extractive distillation
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B1/00—Production of fats or fatty oils from raw materials
    • C11B1/10—Production of fats or fatty oils from raw materials by extracting
    • C11B1/104—Production of fats or fatty oils from raw materials by extracting using super critical gases or vapours
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/86—Products or compounds obtained by genetic engineering
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Water Supply & Treatment (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)

Abstract

L'invention se rapporte à un procédé de préparation d'une composition à haute richesse en squalène produit par fermentation de microorganismes, caractérisé en ce qu'il comprend une étape de purification choisie dans le groupe constitué de l'extraction par CO2 supercritique sur colonne de fractionnement multiétagée fonctionnant à contre-courant avec reflux d'extrait,et de la distillation moléculaire dite de «court trajet».
PCT/FR2013/050812 2012-04-16 2013-04-15 Procédé de raffinage du squalène produit par microalgues WO2013156720A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA2869358A CA2869358C (fr) 2012-04-16 2013-04-15 Procede de raffinage du squalene produit par microalgues
US14/394,813 US9346722B2 (en) 2012-04-16 2013-04-15 Method for refining squalene produced by microalgae
KR1020147028599A KR102192410B1 (ko) 2012-04-16 2013-04-15 미세조류에 의해 생성된 스쿠알렌의 정련방법
EP13720486.3A EP2838630A2 (fr) 2012-04-16 2013-04-15 Procédé de raffinage du squalène produit par microalgues
CN201380020310.3A CN104245076B (zh) 2012-04-16 2013-04-15 用于精炼微藻产生的角鲨烯的方法
IN8554DEN2014 IN2014DN08554A (fr) 2012-04-16 2013-04-15
JP2015506284A JP6216769B2 (ja) 2012-04-16 2013-04-15 微細藻類により産生されるスクアレンを精製する方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR1253496 2012-04-16
FR1253496A FR2989373B1 (fr) 2012-04-16 2012-04-16 Procede de raffinage du squalene produit par microalgues
FR1253614 2012-04-19
FR1253614 2012-04-19

Publications (2)

Publication Number Publication Date
WO2013156720A2 WO2013156720A2 (fr) 2013-10-24
WO2013156720A3 true WO2013156720A3 (fr) 2014-01-09

Family

ID=48289468

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2013/050812 WO2013156720A2 (fr) 2012-04-16 2013-04-15 Procédé de raffinage du squalène produit par microalgues

Country Status (8)

Country Link
US (1) US9346722B2 (fr)
EP (1) EP2838630A2 (fr)
JP (1) JP6216769B2 (fr)
KR (1) KR102192410B1 (fr)
CN (2) CN104245076B (fr)
CA (1) CA2869358C (fr)
IN (1) IN2014DN08554A (fr)
WO (1) WO2013156720A2 (fr)

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ES2675517T3 (es) 2000-01-19 2018-07-11 Dsm Ip Assets B.V. Proceso de extracción sin solvente
EP3617318A1 (fr) 2010-06-01 2020-03-04 DSM IP Assets B.V. Extraction de lipides à partir de cellules et produits ainsi obtenus
CN102787074B (zh) 2011-05-20 2016-06-08 罗盖特兄弟公司 生产角鲨烯的微藻新菌株
CN102787140A (zh) 2011-05-20 2012-11-21 罗盖特兄弟公司 从微藻制备与提取角鲨烯的工艺方法
FR2975705B1 (fr) * 2011-05-27 2014-12-26 Roquette Freres Procede d'extraction du squalene a partir de microalgues
AU2014369042B2 (en) 2013-12-20 2020-04-30 Dsm Ip Assets B.V. Processes for obtaining microbial oil from microbial cells
AU2014369045B2 (en) 2013-12-20 2020-02-27 Dsm Ip Assets B.V. Processes for obtaining microbial oil from microbial cells
KR102426987B1 (ko) 2013-12-20 2022-07-28 디에스엠 아이피 어셋츠 비.브이. 미생물 세포로부터의 미생물 오일의 수득 방법
SG11201605009RA (en) 2013-12-20 2016-07-28 Dsm Ip Assets Bv Processes for obtaining microbial oil from microbial cells
CN106029623A (zh) * 2013-12-20 2016-10-12 帝斯曼知识产权资产管理有限公司 用于从微生物细胞获得微生物油的方法
US20180187121A1 (en) * 2015-06-15 2018-07-05 White Dog Labs, Inc. Method for producing one or more oil-soluble bioproducts
WO2017214497A1 (fr) 2016-06-10 2017-12-14 Clarity Cosmetics Inc. Formulations non comédogènes de soin des cheveux et du cuir chevelu et méthode d'utilisation
CN106588542A (zh) * 2016-12-27 2017-04-26 宁波大红鹰生物工程股份有限公司 一种植物角鲨烯浓缩液及其制备方法
FR3077994B1 (fr) * 2018-02-22 2020-02-28 IFP Energies Nouvelles Separation selective des impuretes presentes dans une coupe hydroalcoolique par recyclage dans une colonne d'extraction liquide-liquide
CN110643420A (zh) * 2019-11-13 2020-01-03 贵州航天乌江机电设备有限责任公司 一种从毛叶山桐子中提取油并精炼的工艺
CN112426739A (zh) * 2020-10-16 2021-03-02 安庆缘启医药科技有限公司 一种分子蒸馏提取抗癌药物的制备工艺

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EP0541999A1 (fr) * 1991-11-15 1993-05-19 MÜLLER-EXTRACT-COMPANY GmbH Procédé et dispositif pour la préparation de squalène à partir de résidu d'huile d'olive
US20040015033A1 (en) * 2000-06-30 2004-01-22 Rudolf Steiner Method for producing squalene
WO2005075614A1 (fr) * 2004-02-09 2005-08-18 Consejo Superior De Investigaciones Científicas Procede d'obtention de composes a haute valeur ajoutee a partir de feuilles d'olivier
EP1818388A1 (fr) * 2006-02-10 2007-08-15 Carotech SDN. BHD Procédé d'obtention de fractions enrichies contenant de composés naturels à partir d'huile de Palme par fluides supercritiques ou presque supercritiques
WO2008142175A1 (fr) * 2007-05-18 2008-11-27 Universidad De Cordoba Procédé d'obtention de squalène
CN102100260A (zh) * 2010-12-03 2011-06-22 滨州学院 酵母油脂及其制备方法和应用
US20110243969A1 (en) * 2008-08-28 2011-10-06 Novartis Ag Production of squalene from hyper-producing yeasts

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FR2584618B1 (fr) 1985-07-09 1989-11-24 Elf Aquitaine Dispositif pour la mise en oeuvre de procedes d'extraction-separation-fractionnement par fluides supercritiques
DE4316620A1 (de) 1993-05-18 1994-11-24 Mueller Extract Co Gmbh Verfahren und Vorrichtung zur Herstellung von Squalen aus Olivenölrückständen
FR2803598B1 (fr) 2000-01-12 2002-04-26 Pharmascience Lab Procede d'extraction des insaponifiables des huiles vegetales au moyen de chloro-1-butane, composition comprenant ces insaponifiables
MY142319A (en) * 2002-08-20 2010-11-15 Malaysian Palm Oil Board Mpob Extraction of palm vitamin e, phytosterols and squalene from palm oil
MY138963A (en) 2003-08-27 2009-08-28 Malaysian Palm Oil Board One-stage and two-stage supercritical fluid extractions of carotenes concentrate, vitamin e concentrate and other minor components concentrates
FR2933403B1 (fr) 2008-07-07 2010-08-27 Sophim Procede d'extration de squalene, de stereols et de vitamine e contenus dans des condensats de raffinage physique et/ou dans des distillats de desodorisation d'huiles vegetales

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Publication number Priority date Publication date Assignee Title
EP0541999A1 (fr) * 1991-11-15 1993-05-19 MÜLLER-EXTRACT-COMPANY GmbH Procédé et dispositif pour la préparation de squalène à partir de résidu d'huile d'olive
US20040015033A1 (en) * 2000-06-30 2004-01-22 Rudolf Steiner Method for producing squalene
WO2005075614A1 (fr) * 2004-02-09 2005-08-18 Consejo Superior De Investigaciones Científicas Procede d'obtention de composes a haute valeur ajoutee a partir de feuilles d'olivier
EP1818388A1 (fr) * 2006-02-10 2007-08-15 Carotech SDN. BHD Procédé d'obtention de fractions enrichies contenant de composés naturels à partir d'huile de Palme par fluides supercritiques ou presque supercritiques
WO2008142175A1 (fr) * 2007-05-18 2008-11-27 Universidad De Cordoba Procédé d'obtention de squalène
US20110243969A1 (en) * 2008-08-28 2011-10-06 Novartis Ag Production of squalene from hyper-producing yeasts
CN102100260A (zh) * 2010-12-03 2011-06-22 滨州学院 酵母油脂及其制备方法和应用

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Title
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NEW BIOTECHNOLOGY SEPTEMPER 2010 ELSEVIER NLD, vol. 27, no. 4, September 2010 (2010-09-01), pages 382 - 389, DOI: 10.1016/J.NBT.2010.04.005 *

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US9346722B2 (en) 2016-05-24
KR102192410B1 (ko) 2020-12-17
WO2013156720A2 (fr) 2013-10-24
CA2869358C (fr) 2020-12-08
JP6216769B2 (ja) 2017-10-18
IN2014DN08554A (fr) 2015-05-15
CN105296552A (zh) 2016-02-03
CA2869358A1 (fr) 2013-10-24
JP2015516152A (ja) 2015-06-11
CN104245076A (zh) 2014-12-24
KR20150006421A (ko) 2015-01-16
EP2838630A2 (fr) 2015-02-25
CN104245076B (zh) 2017-03-01

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