IN2014DN08554A - - Google Patents

Info

Publication number
IN2014DN08554A
IN2014DN08554A IN8554DEN2014A IN2014DN08554A IN 2014DN08554 A IN2014DN08554 A IN 2014DN08554A IN 8554DEN2014 A IN8554DEN2014 A IN 8554DEN2014A IN 2014DN08554 A IN2014DN08554 A IN 2014DN08554A
Authority
IN
India
Prior art keywords
supercritical
fermentation
rich
extraction
preparing
Prior art date
Application number
Inventor
Philippe Looten
Samuel Patinier
Michel Perrut
Vincent Perrut
Original Assignee
Roquette Freres
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR1253496A external-priority patent/FR2989373B1/en
Application filed by Roquette Freres filed Critical Roquette Freres
Publication of IN2014DN08554A publication Critical patent/IN2014DN08554A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L17/00Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
    • A23L17/60Edible seaweed
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/01Hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02Algae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31Hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706Algae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706Algae
    • A61K8/9711Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D11/00Solvent extraction
    • B01D11/04Solvent extraction of solutions which are liquid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D11/00Solvent extraction
    • B01D11/04Solvent extraction of solutions which are liquid
    • B01D11/0403Solvent extraction of solutions which are liquid with a supercritical fluid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D11/00Solvent extraction
    • B01D11/04Solvent extraction of solutions which are liquid
    • B01D11/0426Counter-current multistage extraction towers in a vertical or sloping position
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D3/00Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/34Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping with one or more auxiliary substances
    • B01D3/40Extractive distillation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C5/00Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms
    • C07C5/02Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by hydrogenation
    • C07C5/03Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by hydrogenation of non-aromatic carbon-to-carbon double bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C7/00Purification; Separation; Use of additives
    • C07C7/04Purification; Separation; Use of additives by distillation
    • C07C7/05Purification; Separation; Use of additives by distillation with the aid of auxiliary compounds
    • C07C7/08Purification; Separation; Use of additives by distillation with the aid of auxiliary compounds by extractive distillation
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11BPRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B1/00Production of fats or fatty oils from raw materials
    • C11B1/10Production of fats or fatty oils from raw materials by extracting
    • C11B1/104Production of fats or fatty oils from raw materials by extracting using super critical gases or vapours
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12Unicellular algae; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/19Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/37Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10General cosmetic use
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/86Products or compounds obtained by genetic engineering
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02EREDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00Technologies for the production of fuel of non-fossil origin
    • Y02E50/30Fuel from waste, e.g. synthetic alcohol or diesel
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/54Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Water Supply & Treatment (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)

Abstract

The invention relates to a method for preparing a composition that is very rich in squalene produced by fermentation of micro organisms. The method is characterised in that it comprises a purification step selected from the group including: supercritical CO2 extraction in a multi stage counter current fractionation column with extract reflux and short path molecular distillation.
IN8554DEN2014 2012-04-16 2013-04-15 IN2014DN08554A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1253496A FR2989373B1 (en) 2012-04-16 2012-04-16 PROCESS FOR REFINING SQUALENE PRODUCED BY MICROALOGUES
FR1253614 2012-04-19
PCT/FR2013/050812 WO2013156720A2 (en) 2012-04-16 2013-04-15 Method for refining squalene produced by microalgae

Publications (1)

Publication Number Publication Date
IN2014DN08554A true IN2014DN08554A (en) 2015-05-15

Family

ID=48289468

Family Applications (1)

Application Number Title Priority Date Filing Date
IN8554DEN2014 IN2014DN08554A (en) 2012-04-16 2013-04-15

Country Status (8)

Country Link
US (1) US9346722B2 (en)
EP (1) EP2838630A2 (en)
JP (1) JP6216769B2 (en)
KR (1) KR102192410B1 (en)
CN (2) CN105296552A (en)
CA (1) CA2869358C (en)
IN (1) IN2014DN08554A (en)
WO (1) WO2013156720A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2302065A1 (en) 2000-01-19 2011-03-30 Martek Biosciences Corporation Solventless extraction process
AU2011261455B2 (en) 2010-06-01 2016-03-24 Dsm Ip Assets B.V. Extraction of lipid from cells and products therefrom
CN102787074B (en) 2011-05-20 2016-06-08 罗盖特兄弟公司 Produce the Microalgae new strain of squalene
CN102787140A (en) 2011-05-20 2012-11-21 罗盖特兄弟公司 Method for preparing and extracting squalene by microalgae
FR2975705B1 (en) * 2011-05-27 2014-12-26 Roquette Freres PROCESS FOR EXTRACTING SQUALENE FROM MICROALGUES
MX370606B (en) 2013-12-20 2019-12-18 Dsm Ip Assets Bv Processes for obtaining microbial oil from microbial cells.
US11124736B2 (en) 2013-12-20 2021-09-21 Dsm Ip Assets B.V. Processes for obtaining microbial oil from microbial cells
CN105960235B (en) 2013-12-20 2021-01-08 帝斯曼知识产权资产管理有限公司 Method for obtaining microbial oil from microbial cells
SG11201605052XA (en) 2013-12-20 2016-07-28 Dsm Ip Assets Bv Processes for obtaining microbial oil from microbial cells
MX2016008220A (en) * 2013-12-20 2017-02-20 Dsm Ip Assets Bv Processes for obtaining microbial oil from microbial cells.
EP3307701A4 (en) * 2015-06-15 2019-01-30 White Dog Labs, Inc. Method for producing one or more oil-soluble bioproducts
US9949915B2 (en) 2016-06-10 2018-04-24 Clarity Cosmetics Inc. Non-comedogenic and non-acnegenic hair and scalp care formulations and method for use
CN106588542A (en) * 2016-12-27 2017-04-26 宁波大红鹰生物工程股份有限公司 Plant squalene concentrated solution and preparation method thereof
FR3077994B1 (en) * 2018-02-22 2020-02-28 IFP Energies Nouvelles SELECTIVE SEPARATION OF IMPURITIES PRESENT IN A HYDROALCOHOLIC SECTION BY RECYCLING IN A LIQUID-LIQUID EXTRACTION COLUMN
CN110643420A (en) * 2019-11-13 2020-01-03 贵州航天乌江机电设备有限责任公司 Process for extracting and refining oil from idesia polycarpa
CN112426739A (en) * 2020-10-16 2021-03-02 安庆缘启医药科技有限公司 Preparation process for extracting anticancer medicine by molecular distillation

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2584618B1 (en) 1985-07-09 1989-11-24 Elf Aquitaine DEVICE FOR IMPLEMENTING EXTRACTION-SEPARATION-FRACTIONATION PROCESSES BY SUPERCRITICAL FLUIDS
DE4137733A1 (en) 1991-11-15 1993-05-19 Mueller Extract Co Gmbh METHOD AND DEVICE FOR PREPARING SQUALES FROM OLIVE OIL BACKPACKS
DE4316620A1 (en) 1993-05-18 1994-11-24 Mueller Extract Co Gmbh Process and apparatus for producing squalene from olive oil residues
FR2803598B1 (en) 2000-01-12 2002-04-26 Pharmascience Lab PROCESS FOR EXTRACTING INSAPONIFIABLE FROM VEGETABLE OILS USING CHLORO-1-BUTANE, COMPOSITION COMPRISING SUCH UNSAPONIFIABLE
DE10031994A1 (en) * 2000-06-30 2002-01-10 Cognis Deutschland Gmbh Recovery of squalene, useful for producing squalene used as apolar oil body in cosmetics or pharmaceuticals, uses compressed gas for extraction from intermediate containing hydrocarbon from processing vegetable oil
MY142319A (en) * 2002-08-20 2010-11-15 Malaysian Palm Oil Board Mpob Extraction of palm vitamin e, phytosterols and squalene from palm oil
MY138963A (en) 2003-08-27 2009-08-28 Malaysian Palm Oil Board One-stage and two-stage supercritical fluid extractions of carotenes concentrate, vitamin e concentrate and other minor components concentrates
ES2238183B1 (en) * 2004-02-09 2006-12-16 Consejo Sup. Investig. Cientificas PROCEDURE FOR OBTAINING HIGH VALUE COMPOUNDS ADDED FROM OLIVE LEAF.
EP1818388B1 (en) * 2006-02-10 2010-04-28 Carotech SDN. BHD Process for production of highly enriched fractions of natural compounds from Palm Oil with supercritical and near critical fluids
ES2308924B1 (en) 2007-05-18 2009-11-02 Pradomudo Investigacion Y Desarrollo, S.L(Titular El 50%) PROCEDURE FOR OBTAINING SCALES.
FR2933403B1 (en) 2008-07-07 2010-08-27 Sophim PROCESS FOR EXTRACTING SQUALENE, STEREOLS AND VITAMIN E FROM PHYSICAL REFINING CONDENSATES AND / OR VEGETABLE OIL DEODORIZATION DISTILLATES
US11236366B2 (en) * 2008-08-28 2022-02-01 Novartis Ag Production of squalene from hyper-producing yeasts
CN102100260B (en) * 2010-12-03 2013-07-31 滨州学院 Yeast grease and preparation method and application thereof

Also Published As

Publication number Publication date
WO2013156720A3 (en) 2014-01-09
CN105296552A (en) 2016-02-03
US20150140030A1 (en) 2015-05-21
CN104245076B (en) 2017-03-01
CA2869358C (en) 2020-12-08
KR102192410B1 (en) 2020-12-17
US9346722B2 (en) 2016-05-24
CA2869358A1 (en) 2013-10-24
WO2013156720A2 (en) 2013-10-24
CN104245076A (en) 2014-12-24
JP6216769B2 (en) 2017-10-18
EP2838630A2 (en) 2015-02-25
JP2015516152A (en) 2015-06-11
KR20150006421A (en) 2015-01-16

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