WO2013150578A1 - Dispositif d'administration de médicament - Google Patents

Dispositif d'administration de médicament Download PDF

Info

Publication number
WO2013150578A1
WO2013150578A1 PCT/JP2012/058843 JP2012058843W WO2013150578A1 WO 2013150578 A1 WO2013150578 A1 WO 2013150578A1 JP 2012058843 W JP2012058843 W JP 2012058843W WO 2013150578 A1 WO2013150578 A1 WO 2013150578A1
Authority
WO
WIPO (PCT)
Prior art keywords
drug
container
hollow needle
medicine
transfer device
Prior art date
Application number
PCT/JP2012/058843
Other languages
English (en)
Japanese (ja)
Inventor
福岡幸治
Original Assignee
株式会社メディカルクリエーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社メディカルクリエーション filed Critical 株式会社メディカルクリエーション
Priority to PCT/JP2012/058843 priority Critical patent/WO2013150578A1/fr
Publication of WO2013150578A1 publication Critical patent/WO2013150578A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2072—Venting means for internal venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2086—Filtering means for fluid filtration

Definitions

  • the present invention relates to a technology of an apparatus for transferring a medicine between a syringe barrel and a medicine container.
  • Dangerous drugs are drugs that are routinely used for medical purposes in medical facilities.
  • relatively high levels of mutagenic substances are detected in the urine of healthcare workers working in the environment where they are prepared and administered compared to unexposed healthcare workers, and there are concerns about adverse reproductive effects Has been.
  • the drug is often exposed due to leakage or dripping of the drug when the drug is sucked from the drug container into the syringe or when the drug is injected into the infusion bag in the dispensing operation. More specifically, it is conceivable that the leaked drug directly touches the skin, or vaporized drug or dried drug particles float in the air and are inhaled into the body.
  • Patent Document 4 discloses a technique for reducing a pressure difference between the inside and outside of a container by reducing a pressure difference between the inside and outside of the container and reducing a risk of leakage or dripping of a dangerous drug from the medicine container by attaching a pressure equalizing device to the medicine container at the time of medicine transfer. Proposed.
  • the pressure difference between the inside and outside of the medicine container is eliminated by using a predetermined device.
  • the predetermined device since it is integrated with the medicine transfer device, even if the predetermined device is unnecessary. There is a problem in that it cannot be removed and hinders the operation of the medicine transfer device.
  • the pressure difference between the inside and outside of the medicine container is eliminated by using a predetermined apparatus integrated with the medicine transporting apparatus, but there is no need for the function of equalizing the pressure inside and outside the container.
  • the predetermined apparatus is attached, there is a problem that the medicine transfer apparatus becomes expensive.
  • the present invention proposes a drug transfer device that transfers a drug between a syringe barrel and a drug container while eliminating a pressure difference between the inside and the outside of the drug container using a removable instrument.
  • One form of the medicine transfer device to be disclosed includes a first member connected to the stopper side of the medicine container, a second member connected to the first member at one end, and connected to the syringe barrel at the other end.
  • a drug transfer device for transferring a drug between the drug container and the syringe barrel, wherein the first member is connected to the first member and the first member.
  • a root portion is arranged toward the member side, a first hollow needle member having holes for transferring a drug at the root portion and the tip portion, and a tip portion toward the stopper side of the drug container.
  • the third portion is disposed and the root portion is disposed toward the third member side, and a vent hole is provided at the root portion and the tip portion.
  • a hollow needle member, and the second member has a distal end portion disposed toward the first member side, a root portion disposed toward the syringe barrel side, and a root portion and a distal end.
  • medical agent transfer apparatus to disclose has the said 3rd member in addition to the said structure, and the said 3rd member is a pressure of the said chemical
  • a container pressure adjusting member whose internal volume changes according to the difference, and a tube member that includes the female portion of the fitting mechanism at one end and communicates the container pressure adjusting member and the drug container at the other end,
  • the first member and the third member are detachably connected by fitting the male part and the female part of the fitting mechanism.
  • one form of the disclosed medicine transfer device is characterized in that, in addition to the above configuration, the third member has a filter member that is disposed at the other end of the tube member and allows only gas to pass therethrough.
  • the stopper of the medicine container when the stopper of the medicine container is disposed below and the bottom surface of the medicine container is disposed above, the other end of the tube member is It is located above the bottom surface of the medicine container.
  • one form of the disclosed medicine transfer device is characterized in that the container pressure adjusting member is a bag-like member that can be wound around the tube member and can be expanded and contracted freely.
  • the container pressure adjusting member is a bag-like member that can be wound around the tube member and can be expanded and contracted freely.
  • medical agent transfer apparatus to disclose is characterized by the said 3rd hollow needle member being contained in said 1st hollow needle member.
  • the disclosed drug transfer device transfers a drug between a syringe barrel and a drug container while eliminating a pressure difference between the inside and the outside of the drug container using a removable instrument.
  • FIG. 1 is a diagram showing an outline of a drug transfer system 100 including a drug transfer device 1.
  • the drug transfer system 100 includes a drug container 2, a syringe barrel 6, a first member 8, a second member 38, and a third member 56.
  • the medicine transfer system 100 connects the medicine container 2 and the syringe barrel 6 as a closed system using the first member 8 and the second member 38, and in the connected state, between the medicament container 2 and the syringe barrel 6. Transfer of liquid or gaseous drug.
  • the medicine transfer system 100 connects the first member 8 and the third member 56 so that the pressure inside the medicine container 2 is equalized with the pressure outside the container.
  • the medicine is transferred between the syringe barrels 6.
  • the drug container 2 may be a vial as shown in FIG. 1 or may be an infusion bag as shown in FIG. 2, and a solid / liquid / gas drug is stored inside. As shown in FIG. 3, the medicine transfer device 1 can also apply the medicine container 2 as an infusion line. Moreover, the medicine container 2 is provided with a stopper 4 that is connected to other members and used when the medicine is transferred. The medicine container 2 is connected to the first member 8 on the stopper 4 side.
  • the syringe barrel 6 is also referred to as a syringe, and is a device for injecting or sucking a liquid or gaseous drug, and does not include an injection needle.
  • the syringe barrel 6 is connected to the second member 38 at the syringe barrel connecting portion 52 provided in the second member 38.
  • the first member 8 and the second member 38 are connected, and the first member 8 and the third member 56 are connected.
  • FIG. 4 is a cross-sectional view for explaining a main part of the first member 8.
  • the first member 8 includes a male portion 10 of the fitting mechanism, a first hollow needle member 12, a first elastic member 18, a first fixing member 26, and a first filter member. 20, a second filter member 24, a drug container gripping portion 28, a male portion 30 of the second fitting mechanism, and a third hollow needle member 32.
  • the male part 10 of the fitting mechanism is a male part of a fitting mechanism (locking mechanism) for connecting the first member 8 and the second member 38, and a female part provided in the second member 38 described later.
  • the fitting mechanism is, for example, a mechanism composed of a female part having a nail shape and a male part having a shape for hanging the nail, and the nail and the part to be hooked are engaged with each other.
  • the one member 8 and the second member 38 can be easily connected and locked.
  • the fitting mechanism may have other structures.
  • the first hollow needle member 12 has a hollow needle shape inside, the distal end portion 14 is disposed toward the stopper 4 of the drug container 2, and the root portion 16 is directed toward the connection portion with the second member 38. Be placed. Further, the distal end portion 14 is inserted into the stopper 4 of the drug container 2, and the chemical solution is transferred between the drug container 2 and the syringe barrel 6. Therefore, at least the distal end portion 14 and the root portion 16 are provided with holes for drug transfer.
  • the first elastic member 18 is a spherical member made of a material having elasticity such as silicon or thermoplastic resin.
  • the first elastic member 18 is fixed at a predetermined position in the first member 8 by the first fixing member 26.
  • the predetermined position is a position where the first elastic member 18 closes the hole of the root portion 16 of the first hollow needle member 12.
  • the first fixing member 26 is a member for fixing the first elastic member 18 to a predetermined position in the first member 8 as described above.
  • the first fixing member 26 has a mortar shape with a hole in the bottom, and the first elastic member 18 is fitted into the mortar-shaped portion to thereby provide the first elasticity.
  • the member 18 is fixed at a predetermined position.
  • the first filter member 20 penetrates the elastic members 18, 48, and the elastic member 18 generated by the second hollow needle member 42 inserted into the first hollow needle member 12, It is a member that prevents 48 scraps (hereinafter also referred to as “unnecessary items”) 54 from entering the first hollow needle member 12.
  • the first filter member 20 is disposed between the first elastic member 18 and the hole in the root portion 16 of the first hollow needle member 12.
  • FIG. 5 is a view for explaining the structure of the first filter member 20.
  • the first filter member 20 includes a mesh member 22 obtained by rotating the mesh member 22 about 45 ° to a mesh member 22 in which thread-like members are arranged in a mesh (lattice). It is a stacked configuration.
  • the first filter member 20 is a member installed for the purpose of preventing the shavings 54 of the elastic members 18 and 48 generated by the second hollow needle member 42 from entering the first hollow needle member 12. Therefore, as long as the purpose is achieved, the configuration is not limited to the above.
  • the second filter member 24 does not allow the unnecessary material 54 generated by the second hollow needle member 42 to enter the first hollow needle member 12 (particularly, the distal end portion 14). It is a member to make it.
  • the second filter member 24 is installed inside the first hollow needle member 12. The material and structure of the second filter member 24 are not limited as long as the above object is achieved.
  • FIG. 6A is a front view for explaining the main part of the drug container gripping portion 28, and FIG. 6B is a plan view for explaining the main part of the drug container gripping portion 28.
  • FIGS. 7A to 7C are views for explaining how the size of the medicine container gripping portion 28 is changed in accordance with the stoppers 4 of various sizes.
  • the size of the stopper 4 of the drug container 2 is various such as a diameter of 15 mm, 20 mm, 30 mm. Accordingly, as shown in FIG. 6A, the drug container gripping portion 28 fixes the connection relationship between the drug container 2 and the first member 8 by sandwiching the stopper 4 or neck portion of the drug container 2 from the side. It is a member to do. Moreover, as shown in FIG. 6B, the drug container gripping portion 28 can adjust the size of the connection site to the size of the stopper 4 (or neck portion) of the drug container 2.
  • the medicine container gripping portion 28 matches the size of the plug 4 (or neck portion) of the medicine container 2 with the size of the connecting portion, so that the stopper 4
  • the connection relationship between the drug container 2 and the first member 8 is fixed by sandwiching from the left and right sides or the four sides of the (or neck portion).
  • the third hollow needle member 32 has a hollow needle shape inside, the distal end portion 34 is disposed toward the stopper 4 of the drug container 2, and the root portion 36 is directed toward the connection portion with the third member 56. Be placed.
  • the third member 56 is a member for keeping the pressure in the drug container 2 constant (making the pressure inside and outside the drug container 2 uniform).
  • the drug solution is transferred between the drug container 2 and the syringe barrel 6 in a state where the tip part 34 of the third hollow needle member 32 is inserted into the stopper 4 of the drug container 2, at least the tip part 34 and The root portion 36 is provided with a hole for the gas in the drug container 2 to move.
  • the male part 30 of the second fitting mechanism is a male part of a fitting mechanism (locking mechanism) for connecting the first member 8 and the third member 56, and a third member 56 to be described later is provided.
  • the second fitting mechanism is, for example, a mechanism that includes a female part that has a claw shape and a male part that has a shape that hangs the claw, and the claw and the part that hangs the claw are engaged with each other.
  • the first member 8 and the third member 56 can be easily connected and locked.
  • the second fitting mechanism may have other structures.
  • the male part 30 of the second fitting mechanism is arranged at the root part 36 of the third hollow needle member 32. Then, as shown in FIG. 4, the male part 30 (the root part 36 of the third hollow needle member 32) of the second fitting mechanism does not connect the first member 8 and the third member 56. In order to prevent the medicine in the medicine container 2 from leaking out, the hole can be closed with a stopper.
  • the 3rd hollow needle member 32 may be a form (included in the 1st hollow needle member 12) which shares the front-end
  • the form provided separately from the 1st hollow needle member 12 may be sufficient.
  • FIG. 8 is a cross-sectional view for explaining a main part of the second member 38.
  • the second member 38 includes the syringe barrel connection portion 52, the female portion 40 of the fitting mechanism, the second hollow needle member 42, the second elastic member 48, and the second fixing member 50.
  • the syringe barrel connection portion 52 is a portion connected to the syringe barrel 6 in which the liquid or gaseous medicine to be transferred is stored, and is located at the other end of the portion to which the first member 8 is connected. There is no particular limitation regarding the mechanism in which the syringe barrel connection portion 52 and the syringe barrel 6 are connected.
  • the female part 40 of the fitting mechanism is a female part of a fitting mechanism (locking mechanism) for connecting the first member 8 and the second member 38, and the male part 10 included in the first member 8 is connected to the female part 40.
  • the fitting mechanism is, for example, a mechanism composed of a female part having a nail shape and a male part having a shape for hanging the nail, and the nail and the part to be hooked are engaged with each other.
  • the one member 8 and the second member 38 can be easily connected and locked.
  • the fitting mechanism may have other structures.
  • the second hollow needle member 42 has a hollow needle shape inside, the distal end portion 44 is disposed toward the first member 8 (first hollow needle portion 12), and the root portion 46 is connected to the syringe barrel 6. It arrange
  • the distal end portion 44 is supported while being inserted into a second elastic member 48 described later, and the root portion 46 is fixed to the syringe barrel connection portion 52.
  • the first member 8 and the second member 38 are connected when the medicine is transferred, and the second hollow needle member 42 is inserted into the first hollow needle member 12. Therefore, the direction of the second hollow needle member 42 is fixed in a predetermined direction, and the connection operation between the members 8 and 38 (insertion operation of the hollow needle members 12 and 42) can be performed reliably and easily.
  • the drug solution is transferred between the drug container 2 and the syringe barrel 6 via the second hollow needle member 42, at least the tip 44 and the root 46 are provided with holes for drug transfer.
  • the second elastic member 48 is a spherical member made of a material having elasticity such as silicon or thermoplastic resin.
  • the second elastic member 48 is fixed at a predetermined position in the second member 38 by the second fixing member 50.
  • the predetermined position means that when the first member 8 and the second member 38 are connected, the first elastic member 18 and the second elastic member 48 are applied with a predetermined force. It is a position to touch.
  • the second fixing member 50 is a member for fixing the second elastic member 48 to a predetermined position in the second member 38 as described above.
  • the second fixing member 50 has a mortar shape with a hole in the bottom, and a second elastic member 48 having a spherical shape is fitted into the mortar-shaped portion, thereby providing a second elasticity.
  • the member 48 is fixed at a predetermined position.
  • FIGS. 9 and 10 are cross-sectional views for explaining a connection mode of the first member 8 and the second member 38.
  • the male part 10 and the female part 40 of the fitting mechanism for connecting the first member 8 and the second member 38 are fitted together, The member 8 and the second member 38 are connected.
  • the first elastic member 18 and the second elastic member 48 come into contact with each other, and the contact portions of the elastic members 18 and 48 are crushed, and the first member 8 and the second elastic member 48 are brought into contact with each other.
  • the connection part with the member 38 becomes a closed system closed from the outside.
  • the distal end portion 44 of the second hollow needle member 42 supported by the second elastic member 48 is moved to the second procedure while maintaining the above state.
  • the first elastic member 48 and the first elastic member 18 are pushed and penetrated through the first hollow needle member 12 through the root portion 16.
  • the second hollow needle member 42 may scrape the elastic members 18 and 48, the first filter member 20 and the second filter member 24 prevent permeation of the shavings 54.
  • the third member 56 includes a female portion 58 of the second fitting mechanism, a pipe member 60, a third filter member 66, and a container pressure adjusting member 68.
  • the female portion 58 of the second fitting mechanism is a female portion of a fitting mechanism (locking mechanism) for connecting the first member 8 and the third member 56, and the male member included in the first member 8.
  • the second fitting mechanism is, for example, a mechanism that includes a female part that has a claw shape and a male part that has a shape that hangs the claw, and the claw and the part that hangs the claw are engaged with each other.
  • the first member 8 and the third member 56 can be easily connected and locked.
  • the second fitting mechanism may have other structures.
  • the female portion 58 of the second fitting mechanism is disposed at the end portion 62 of the tube member 60. As shown in FIG. 11, the female portion 58 (end portion 62 of the tube member 60) of the second fitting mechanism has a hole by a plug when the first member 8 and the third member 56 are not connected. It is also possible to make the state closed.
  • the tube member 60 is a tubular member that allows the drug container 2 and the container pressure adjusting member 68 to communicate with each other.
  • the tube member 60 includes a female portion 58 of the second fitting mechanism at one end 62 and the container pressure adjusting member 68 at the other end 64.
  • the communication part is provided.
  • the tube member 60 may be provided with a communication portion with the female portion 58 of the second fitting mechanism and the container pressure adjusting member 68 at a portion other than the end portion.
  • the tube member 60 serves as a gas flow path in the drug container 2, but the drug in the drug container 2 may flow in.
  • the container pressure adjusting member 68 is a member that changes its own volume when the gas in the communicating medicine container 2 flows in, and as a result, uniformizes the pressure in the communicating medicine container 2 with the external pressure.
  • the container pressure adjusting member 68 communicates with the drug container 2 via the tube member 60 connected to the end.
  • the container pressure adjusting member 68 may be a container having a bellows-like side surface, and its volume may be changed by expanding or contracting the bellows-shaped part.
  • the container pressure adjusting member 68 is a soft bag-like container, and may be configured to be wound around the tube member 60 when not in use, or may have other shapes.
  • the third filter member 66 is a member having a function of allowing gas to pass but not allowing liquid (medicine) in the drug container 2 to pass (hard to allow liquid to pass).
  • the third filter member 66 is disposed at an inlet site where the container pressure adjusting member 68 is communicated with the drug container 2 by the tube member 60.
  • the operator inserts the distal end portion 14 of the first hollow needle member 12 included in the first member 8 shown in FIG. 2 and the first member 8 are connected.
  • the operator adjusts the size of the drug container gripping portion 28 in accordance with the size of the diameter of the plug portion 4 of the drug container 2, and the plug portion
  • the connection relationship between the drug container 2 and the first member 8 is fixed by sandwiching from the left and right sides or four sides of 4 (or the neck portion).
  • the operator fits the male part 10 and the female part 40 of the fitting mechanism and connects the first member 8 and the second member 38.
  • the first elastic member 18 and the second elastic member 48 come into contact with each other, and the contact portions of the elastic members 18 and 48 are crushed, and the first member 8 and the second elastic member 48 are brought into contact with each other.
  • the connection part with the member 38 becomes a closed system closed from the outside.
  • the operator As the fourth procedure, the operator, as shown in FIG. 10, maintains the state where the third procedure is completed, and the second hollow needle member supported by the second elastic member 48. The distal end portion 44 of 42 is pushed and penetrated in the second elastic member 48 and the first elastic member 18. Further, the operator inserts the second hollow needle member 42 into the first hollow needle member 12 from the root portion 16. At this time, since the second hollow needle member 42 may scrape the elastic members 18 and 48, the first filter member 20 and the second filter member 24 prevent permeation of the shavings 54. As a fifth procedure, the operator connects the syringe barrel 6 to the syringe barrel connecting portion 52 provided in the second member 38 as shown in FIG. 1 or FIG.
  • the operator transfers the drug from the syringe barrel 6 toward the drug container 2 or from the drug container 2 toward the syringe barrel 6. At that time, the operator transfers the medicine by inverting the medicine container 2 or appropriately operating the syringe barrel 6. (2) Pressure equalization in the drug container
  • FIG. 1 a method of using the drug transfer device 1, that is, a method of pressure equalizing operation in the drug container 2 in the drug transfer system 100 including the drug transfer device 1 will be described.
  • drug transfer when the drug container 2 is a vial and drug transfer when the drug container 2 is an infusion bag as shown in FIG. 2 are assumed.
  • the operator connects the first member 8 shown in FIG. 10 and the third member 56 shown in FIG. 11 to obtain the state of the medicine transfer device 1 shown in FIG. Specifically, the male part 30 of the second fitting mechanism provided in the first member 8 and the female part 58 of the second fitting mechanism provided in the third member 56 are fitted together, and the first member 8 is fitted. And the third member 56 are connected.
  • the operator uses the medicine transfer device 1 to which the first member 8, the second member 38, and the third member 56 are connected.
  • the gas or liquid drug, air, diluent, etc.
  • the gas (air) in the medicine container 2 flows into the container pressure adjusting member 68 through the third hollow needle member 32, the tube member 60, and the third filter member 66. Therefore, the pressure inside the medicine container 2 becomes substantially equal to the pressure outside the medicine container 2, and the risk of leakage or dripping of dangerous medicine from the stopper 4 of the medicine container 2 is reduced.
  • the operator moves the medicine in the medicine container 2 from the medicine container 2 to the syringe barrel 6 (collection) by inverting the vertical position of the medicine transportation system 100. To do.
  • the medicine in the medicine container 2 flows into the third hollow needle member 32 and the pipe member 60, but the end portion 64 of the pipe member 60 from the medicine liquid surface in the medicine container 2. Exists in the upper position, so that the medicine in the medicine container 2 does not enter the container pressure adjusting member 68.
  • the medicine transfer device 1 if the end portion 64 of the tube member 60 is arranged at the upper position from the bottom surface of the medicine container 2, the medicine enters the container pressure adjusting member 68 even if the amount of the medicine in the medicine container 2 increases. There is nothing. By doing so, in the medicine transfer device 1, the third filter member 66 is not wetted by the medicine, and the blockage of the gas flow path called a so-called air block does not occur.
  • the medicine transfer device 1 can reduce the risk of leakage and dripping of the medicine from the medicine container 2 when mixing the medicine by equalizing the pressure inside and outside the medicine container 2 by the third member 56. .
  • the medicine transfer device 1 can remove the instrument 56 for equalizing the pressure inside and outside the medicine container 2. Therefore, the medicine transfer device 1 may be attached to the instrument 56 only when it is necessary to equalize the pressure inside and outside the medicine container 2, and the operability during medicine transfer is improved.
  • the medicine transfer device 1 can remove the instrument 56 for equalizing the pressure inside and outside the medicine container 2, if the instrument 56 is not necessary, the medicine transfer apparatus 1 that does not include the instrument 56 can be manufactured and sold. The selling price can be reduced by reducing the manufacturing cost.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

L'invention concerne un dispositif d'administration de médicament (1) qui administre un médicament entre un corps de seringue (6) et un récipient de médicament (2) tout en permettant à la différence de pression à l'intérieur et à l'extérieur du récipient de médicament (2) d'être éliminée par utilisation d'un appareil amovible. Le dispositif d'administration de médicament (1) de la présente invention comprend un premier élément (8) relié au récipient de médicament (2) sur le côté d'une butée (4), et un deuxième élément (38) relié à une extrémité au premier élément (8) et relié à l'autre extrémité au corps de seringue (6). Le premier élément (8) comprend : la partie mâle (30) d'un mécanisme d'adaptation qui relie de façon détachable le premier élément (8) et un troisième élément (56) relié au premier élément (8) et qui est conçu pour maintenir la pression d'air constante à l'intérieur du récipient de médicament (2); un premier élément d'aiguille creuse (12) comprenant des trous dans la partie base (16) et la partie pointe (14) pour transférer un médicament ; et un troisième élément d'aiguille creuse (32) comprenant des trous d'air dans la partie base (36) et la partie pointe (34). Le deuxième élément (38) comprend un deuxième élément d'aiguille creuse (42) comprenant des trous dans la partie base (46) et la partie pointe (44) pour administrer le médicament. Le deuxième élément d'aiguille creuse (42) est introduit dans le premier élément d'aiguille creuse (12), et le premier élément d'aiguille creuse (12) et le troisième élément d'aiguille creuse (32) sont introduits dans la butée (4) du récipient de médicament (2), et le médicament est administré à travers le premier élément d'aiguille creuse (12) et le deuxième élément d'aiguille creuse (42).
PCT/JP2012/058843 2012-04-02 2012-04-02 Dispositif d'administration de médicament WO2013150578A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/JP2012/058843 WO2013150578A1 (fr) 2012-04-02 2012-04-02 Dispositif d'administration de médicament

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2012/058843 WO2013150578A1 (fr) 2012-04-02 2012-04-02 Dispositif d'administration de médicament

Publications (1)

Publication Number Publication Date
WO2013150578A1 true WO2013150578A1 (fr) 2013-10-10

Family

ID=49300109

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2012/058843 WO2013150578A1 (fr) 2012-04-02 2012-04-02 Dispositif d'administration de médicament

Country Status (1)

Country Link
WO (1) WO2013150578A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112566607A (zh) * 2018-08-07 2021-03-26 伊奎希尔德医疗有限公司 具有可移动间隔件的间隔件保持器

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60501342A (ja) * 1983-05-20 1985-08-22 グスタフソン，ベングト 密封容器の圧力平衡装置
JPH05200098A (ja) * 1991-01-30 1993-08-10 Vincent L Vaillancourt 閉鎖系コネクタ組立体
JPH10295780A (ja) * 1997-04-22 1998-11-10 Becton Dickinson & Co バイアル及びアンプルからの流体にアクセスする流体移送装置及びその装置を使用して流体を移送する方法
JP2010124898A (ja) * 2008-11-25 2010-06-10 Jms Co Ltd コネクタ
EP2319477A1 (fr) * 2009-11-06 2011-05-11 F. Hoffmann-La Roche AG Dispositif de remplissage d'un conteneur de réservoir flexible dans une chambre à pression négative

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60501342A (ja) * 1983-05-20 1985-08-22 グスタフソン，ベングト 密封容器の圧力平衡装置
JPH05200098A (ja) * 1991-01-30 1993-08-10 Vincent L Vaillancourt 閉鎖系コネクタ組立体
JPH10295780A (ja) * 1997-04-22 1998-11-10 Becton Dickinson & Co バイアル及びアンプルからの流体にアクセスする流体移送装置及びその装置を使用して流体を移送する方法
JP2010124898A (ja) * 2008-11-25 2010-06-10 Jms Co Ltd コネクタ
EP2319477A1 (fr) * 2009-11-06 2011-05-11 F. Hoffmann-La Roche AG Dispositif de remplissage d'un conteneur de réservoir flexible dans une chambre à pression négative

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112566607A (zh) * 2018-08-07 2021-03-26 伊奎希尔德医疗有限公司 具有可移动间隔件的间隔件保持器
JP2021532904A (ja) * 2018-08-07 2021-12-02 エクアシールド メディカル リミテッド 可動セプタムを備えるセプタムホルダ
JP7461336B2 (ja) 2018-08-07 2024-04-03 エクアシールド メディカル リミテッド 可動セプタムを備えるセプタムホルダ

Similar Documents

Publication Publication Date Title
JP5510985B2 (ja) 薬剤移送装置
US11690788B2 (en) System for closed transfer of fluids
JP5510986B2 (ja) 薬剤移送装置
JP6259055B2 (ja) カニューレ用の封止システム
JP2018164817A (ja) バイアル・アクセス・キャップ及び重力アシスト・バルブを有するシリンジ
US10010481B2 (en) Flexible package with a sealed sterile chamber for the reconsitution and administration of fluid medicinal or nutritional substances instillable into the body of a patient
US20150290079A1 (en) Drug container storage device, drug container storage system, and method for sucking drug
JP6636182B2 (ja) 通気式薬瓶アダプタと通気式液瓶アダプタとを備えるデュアルバイアルアダプタアセンブリ
WO2011011048A2 (fr) Trousses à perfusion intraveineuse pratiques de transfert de flacon et procédés associés
US20170246085A1 (en) Liquid transfer system
WO2013150578A1 (fr) Dispositif d'administration de médicament
WO2015049730A1 (fr) Trousse d'administration de médicament
WO2013150580A1 (fr) Dispositif d'administration de médicament
WO2015049729A1 (fr) Dispositif d'administration de médicament
JP7137620B2 (ja) 通気式雌型瓶アダプターの対を含む二重瓶アダプター集合体
WO2013150577A1 (fr) Dispositif d'administration de médicament
JP7495389B2 (ja) 可撓性容器から薬剤を移送するための閉鎖式システム
JP5026590B2 (ja) 医療装置と共に使用する取付具
JP2022031497A (ja) 可撓性容器から薬剤を移送するための閉鎖式システム

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12873868

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205 DATED 09/12/2014)

NENP Non-entry into the national phase

Ref country code: JP

NENP Non-entry into the national phase

Ref country code: JP

122 Ep: pct application non-entry in european phase

Ref document number: 12873868

Country of ref document: EP

Kind code of ref document: A1