WO2013150578A1

WO2013150578A1 - Drug delivery device

Info

Publication number: WO2013150578A1
Application number: PCT/JP2012/058843
Authority: WO
Inventors: 福岡幸治
Original assignee: 株式会社メディカルクリエーション
Priority date: 2012-04-02
Filing date: 2012-04-02
Publication date: 2013-10-10

Abstract

This drug delivery device (1) delivers a drug between a syringe barrel (6) and a drug container (2) while allowing the pressure difference inside and outside of the drug container (2) to be eliminated by use of a removable apparatus. This drug delivery device (1) includes a first member (8) connected to the drug container (2) on the side of a stopper (4), and a second member (38) connected at one end to the first member (8) and connected at the other end to the syringe barrel (6). The first member (8) includes: the male portion (30) of a fitting mechanism which detachably connects the first member (8) and a third member (56) connected to the first member (8) and which is for maintaining the air pressure inside of the drug container (2) constant; a first hollow needle member (12) provided with holes in the base portion (16) and the tip portion (14) for transferring a drug; and a third hollow needle member (32) provided with air holes in the base portion (36) and the tip portion (34). The second member (38) includes a second hollow needle member (42) provided with holes in the base portion (46) and the tip portion (44) for delivering the drug. The second hollow needle member (42) is inserted into the first hollow needle member (12), and the first hollow needle member (12) and the third hollow needle member (32) are inserted into the stopper (4) of the drug container (2), and the drug is delivered through the first hollow needle member (12) and the second hollow needle member (42).

Description

Drug transfer device

The present invention relates to a technology of an apparatus for transferring a medicine between a syringe barrel and a medicine container.

There are various types of dangerous drugs such as anti-cancer drugs used in medical facilities, including therapeutic radiopharmaceuticals. Dangerous drugs are drugs that are routinely used for medical purposes in medical facilities. However, relatively high levels of mutagenic substances are detected in the urine of healthcare workers working in the environment where they are prepared and administered compared to unexposed healthcare workers, and there are concerns about adverse reproductive effects Has been.

The US Occupational Health and Safety Agency has published guidelines on the handling of anti-neoplastic drugs and other hazardous drugs by health care professionals, and the National Institutes of Health (NIH: National Institutes of Health) and other dangerous drugs There are provisions regarding the handling of However, there are still many situations in which medical personnel and patients are unintentionally exposed to dangerous drugs when they are handled in medical facilities. In that case, the route of exposure is often via the percutaneous or oral route of a dangerous pharmaceutical gas or liquid.

Specifically, the drug is often exposed due to leakage or dripping of the drug when the drug is sucked from the drug container into the syringe or when the drug is injected into the infusion bag in the dispensing operation. More specifically, it is conceivable that the leaked drug directly touches the skin, or vaporized drug or dried drug particles float in the air and are inhaled into the body.

In view of the above situation, when transferring a dangerous drug between containers, an attempt is made to prevent exposure of a medical worker and a patient due to the dangerous drug by making the container between closed containers. Many medical devices for performing have been developed (see Patent Documents 1 to 6).

In particular, Patent Document 4 discloses a technique for reducing a pressure difference between the inside and outside of a container by reducing a pressure difference between the inside and outside of the container and reducing a risk of leakage or dripping of a dangerous drug from the medicine container by attaching a pressure equalizing device to the medicine container at the time of medicine transfer. Proposed.

JP 2010-521219 A JP 2010-525920 A JP 2010-528808 A JP 2010-528809 A JP 2010-528810 A JP 2010-537900 A

However, in the above technique, the pressure difference between the inside and outside of the medicine container is eliminated by using a predetermined device. However, since it is integrated with the medicine transfer device, even if the predetermined device is unnecessary. There is a problem in that it cannot be removed and hinders the operation of the medicine transfer device.

In the above technique, the pressure difference between the inside and outside of the medicine container is eliminated by using a predetermined apparatus integrated with the medicine transporting apparatus, but there is no need for the function of equalizing the pressure inside and outside the container. However, since the predetermined apparatus is attached, there is a problem that the medicine transfer apparatus becomes expensive.

Therefore, in view of the above problems, the present invention proposes a drug transfer device that transfers a drug between a syringe barrel and a drug container while eliminating a pressure difference between the inside and the outside of the drug container using a removable instrument.

One form of the medicine transfer device to be disclosed includes a first member connected to the stopper side of the medicine container, a second member connected to the first member at one end, and connected to the syringe barrel at the other end. A drug transfer device for transferring a drug between the drug container and the syringe barrel, wherein the first member is connected to the first member and the first member. A male part of a fitting mechanism for detachably connecting a third member for keeping the air pressure in the container constant, and a tip part arranged toward the stopper side of the drug container, the second part A root portion is arranged toward the member side, a first hollow needle member having holes for transferring a drug at the root portion and the tip portion, and a tip portion toward the stopper side of the drug container. The third portion is disposed and the root portion is disposed toward the third member side, and a vent hole is provided at the root portion and the tip portion. A hollow needle member, and the second member has a distal end portion disposed toward the first member side, a root portion disposed toward the syringe barrel side, and a root portion and a distal end. A second hollow needle member having a hole for transferring a drug to the part, and when the first member and the second member are connected, the second hollow needle member is The first hollow needle member and the first hollow needle member are inserted into one hollow needle member, and the first hollow member and the third hollow needle member are inserted into the stopper of the drug container. The medicine is transferred between the medicine container and the syringe barrel through the second hollow needle member inserted into the medicine container.

Moreover, one form of the chemical | medical agent transfer apparatus to disclose has the said 3rd member in addition to the said structure, and the said 3rd member is a pressure of the said chemical | medical agent container which communicates with the female part of the said fitting mechanism. A container pressure adjusting member whose internal volume changes according to the difference, and a tube member that includes the female portion of the fitting mechanism at one end and communicates the container pressure adjusting member and the drug container at the other end, The first member and the third member are detachably connected by fitting the male part and the female part of the fitting mechanism.

Further, one form of the disclosed medicine transfer device is characterized in that, in addition to the above configuration, the third member has a filter member that is disposed at the other end of the tube member and allows only gas to pass therethrough.

Further, in one form of the disclosed medicine transfer device, in addition to the above configuration, when the stopper of the medicine container is disposed below and the bottom surface of the medicine container is disposed above, the other end of the tube member is It is located above the bottom surface of the medicine container.

In addition to the above configuration, one form of the disclosed medicine transfer device is characterized in that the container pressure adjusting member is a bag-like member that can be wound around the tube member and can be expanded and contracted freely. To do.
Moreover, in addition to the said structure, one form of the chemical | medical agent transfer apparatus to disclose is characterized by the said 3rd hollow needle member being contained in said 1st hollow needle member.

The disclosed drug transfer device transfers a drug between a syringe barrel and a drug container while eliminating a pressure difference between the inside and the outside of the drug container using a removable instrument.

It is a figure which shows an example of the chemical | medical agent transfer system containing the chemical | medical agent transfer apparatus which concerns on this Embodiment. It is a figure which shows an example of the chemical | medical agent transfer system containing the chemical | medical agent transfer apparatus which concerns on this Embodiment. It is a figure which shows an example of the chemical | medical agent transfer system containing the chemical | medical agent transfer apparatus which concerns on this Embodiment. It is sectional drawing for demonstrating the principal part of the 1st member which concerns on this Embodiment. It is a top view for demonstrating the principal part of the 1st filter member which concerns on this Embodiment. It is a figure for demonstrating the principal part of the chemical | medical agent container holding part which concerns on this Embodiment. It is a figure for demonstrating the example of application of the chemical | medical agent container holding part which concerns on this Embodiment. It is sectional drawing for demonstrating the principal part of the 2nd member which concerns on this Embodiment. It is sectional drawing for demonstrating the connection aspect of the 1st member and 2nd member which concern on this Embodiment. It is sectional drawing for demonstrating the connection aspect of the 1st member and 2nd member which concern on this Embodiment. It is sectional drawing for demonstrating the principal part of the 3rd member which concerns on this Embodiment. It is sectional drawing for demonstrating the connection aspect of the 1st member which concerns on this Embodiment, a 2nd member, and a 3rd member. It is a figure explaining the effect which the medicine transfer device concerning this embodiment has.

DESCRIPTION OF EMBODIMENTS Embodiments for carrying out the present invention will be described with reference to the drawings.
(Structure of the medicine transfer device according to the present embodiment)

The structure of the medicine transfer device 1 according to the present embodiment will be described with reference to FIGS. FIG. 1 is a diagram showing an outline of a drug transfer system 100 including a drug transfer device 1. As shown in FIG. 1, the drug transfer system 100 includes a drug container 2, a syringe barrel 6, a first member 8, a second member 38, and a third member 56.

The medicine transfer system 100 connects the medicine container 2 and the syringe barrel 6 as a closed system using the first member 8 and the second member 38, and in the connected state, between the medicament container 2 and the syringe barrel 6. Transfer of liquid or gaseous drug.

Furthermore, the medicine transfer system 100 connects the first member 8 and the third member 56 so that the pressure inside the medicine container 2 is equalized with the pressure outside the container. The medicine is transferred between the syringe barrels 6.

The drug container 2 may be a vial as shown in FIG. 1 or may be an infusion bag as shown in FIG. 2, and a solid / liquid / gas drug is stored inside. As shown in FIG. 3, the medicine transfer device 1 can also apply the medicine container 2 as an infusion line. Moreover, the medicine container 2 is provided with a stopper 4 that is connected to other members and used when the medicine is transferred. The medicine container 2 is connected to the first member 8 on the stopper 4 side.

The syringe barrel 6 is also referred to as a syringe, and is a device for injecting or sucking a liquid or gaseous drug, and does not include an injection needle. The syringe barrel 6 is connected to the second member 38 at the syringe barrel connecting portion 52 provided in the second member 38.
In addition, as shown in FIG. 1, the first member 8 and the second member 38 are connected, and the first member 8 and the third member 56 are connected.

From here, the 1st member 8 is demonstrated using FIG. FIG. 4 is a cross-sectional view for explaining a main part of the first member 8. As shown in FIG. 4, the first member 8 includes a male portion 10 of the fitting mechanism, a first hollow needle member 12, a first elastic member 18, a first fixing member 26, and a first filter member. 20, a second filter member 24, a drug container gripping portion 28, a male portion 30 of the second fitting mechanism, and a third hollow needle member 32.

The male part 10 of the fitting mechanism is a male part of a fitting mechanism (locking mechanism) for connecting the first member 8 and the second member 38, and a female part provided in the second member 38 described later. By fitting in 40, the first member 8 and the second member 38 are connected by a simple operation. The fitting mechanism is, for example, a mechanism composed of a female part having a nail shape and a male part having a shape for hanging the nail, and the nail and the part to be hooked are engaged with each other. The one member 8 and the second member 38 can be easily connected and locked. The fitting mechanism may have other structures.

The first hollow needle member 12 has a hollow needle shape inside, the distal end portion 14 is disposed toward the stopper 4 of the drug container 2, and the root portion 16 is directed toward the connection portion with the second member 38. Be placed. Further, the distal end portion 14 is inserted into the stopper 4 of the drug container 2, and the chemical solution is transferred between the drug container 2 and the syringe barrel 6. Therefore, at least the distal end portion 14 and the root portion 16 are provided with holes for drug transfer.

The first elastic member 18 is a spherical member made of a material having elasticity such as silicon or thermoplastic resin. The first elastic member 18 is fixed at a predetermined position in the first member 8 by the first fixing member 26. Here, the predetermined position is a position where the first elastic member 18 closes the hole of the root portion 16 of the first hollow needle member 12.

The first fixing member 26 is a member for fixing the first elastic member 18 to a predetermined position in the first member 8 as described above. The first fixing member 26 has a mortar shape with a hole in the bottom, and the first elastic member 18 is fitted into the mortar-shaped portion to thereby provide the first elasticity. The member 18 is fixed at a predetermined position.

As will be described later, the first filter member 20 penetrates the

elastic members

18, 48, and the elastic member 18 generated by the second hollow needle member 42 inserted into the first hollow needle member 12, It is a member that prevents 48 scraps (hereinafter also referred to as “unnecessary items”) 54 from entering the first hollow needle member 12. The first filter member 20 is disposed between the first elastic member 18 and the hole in the root portion 16 of the first hollow needle member 12.

Here, FIG. 5 is a view for explaining the structure of the first filter member 20. As shown in FIG. 5, the first filter member 20 includes a mesh member 22 obtained by rotating the mesh member 22 about 45 ° to a mesh member 22 in which thread-like members are arranged in a mesh (lattice). It is a stacked configuration. However, the first filter member 20 is a member installed for the purpose of preventing the shavings 54 of the

elastic members

18 and 48 generated by the second hollow needle member 42 from entering the first hollow needle member 12. Therefore, as long as the purpose is achieved, the configuration is not limited to the above.

Similar to the first filter member 20, the second filter member 24 does not allow the unnecessary material 54 generated by the second hollow needle member 42 to enter the first hollow needle member 12 (particularly, the distal end portion 14). It is a member to make it. The second filter member 24 is installed inside the first hollow needle member 12. The material and structure of the second filter member 24 are not limited as long as the above object is achieved.

Next, the drug container gripping portion 28 will be described with reference to FIGS. FIG. 6A is a front view for explaining the main part of the drug container gripping portion 28, and FIG. 6B is a plan view for explaining the main part of the drug container gripping portion 28. FIGS. 7A to 7C are views for explaining how the size of the medicine container gripping portion 28 is changed in accordance with the stoppers 4 of various sizes.

The size of the stopper 4 of the drug container 2 is various such as a diameter of 15 mm, 20 mm, 30 mm. Accordingly, as shown in FIG. 6A, the drug container gripping portion 28 fixes the connection relationship between the drug container 2 and the first member 8 by sandwiching the stopper 4 or neck portion of the drug container 2 from the side. It is a member to do. Moreover, as shown in FIG. 6B, the drug container gripping portion 28 can adjust the size of the connection site to the size of the stopper 4 (or neck portion) of the drug container 2.

Then, as shown in FIGS. 7A to 7C, the medicine container gripping portion 28 matches the size of the plug 4 (or neck portion) of the medicine container 2 with the size of the connecting portion, so that the stopper 4 The connection relationship between the drug container 2 and the first member 8 is fixed by sandwiching from the left and right sides or the four sides of the (or neck portion).

Next, the third hollow needle member 32 and the male part 30 of the second fitting mechanism will be described with reference to FIG. The third hollow needle member 32 has a hollow needle shape inside, the distal end portion 34 is disposed toward the stopper 4 of the drug container 2, and the root portion 36 is directed toward the connection portion with the third member 56. Be placed. Here, as will be described in detail later, the third member 56 is a member for keeping the pressure in the drug container 2 constant (making the pressure inside and outside the drug container 2 uniform).

In addition, since the drug solution is transferred between the drug container 2 and the syringe barrel 6 in a state where the tip part 34 of the third hollow needle member 32 is inserted into the stopper 4 of the drug container 2, at least the tip part 34 and The root portion 36 is provided with a hole for the gas in the drug container 2 to move.

The male part 30 of the second fitting mechanism is a male part of a fitting mechanism (locking mechanism) for connecting the first member 8 and the third member 56, and a third member 56 to be described later is provided. By fitting into the female portion 58 provided, the first member 8 and the third member 56 are detachably connected by a simple operation. The second fitting mechanism is, for example, a mechanism that includes a female part that has a claw shape and a male part that has a shape that hangs the claw, and the claw and the part that hangs the claw are engaged with each other. The first member 8 and the third member 56 can be easily connected and locked. The second fitting mechanism may have other structures.

Further, the male part 30 of the second fitting mechanism is arranged at the root part 36 of the third hollow needle member 32. Then, as shown in FIG. 4, the male part 30 (the root part 36 of the third hollow needle member 32) of the second fitting mechanism does not connect the first member 8 and the third member 56. In order to prevent the medicine in the medicine container 2 from leaking out, the hole can be closed with a stopper.

In addition, as shown in FIG. 4, the 3rd hollow needle member 32 may be a form (included in the 1st hollow needle member 12) which shares the front-end | tip part with the 1st hollow needle member 12, The form provided separately from the 1st hollow needle member 12 may be sufficient.

Next, the second member 38 will be described with reference to FIG. FIG. 8 is a cross-sectional view for explaining a main part of the second member 38. As shown in FIG. 8, the second member 38 includes the syringe barrel connection portion 52, the female portion 40 of the fitting mechanism, the second hollow needle member 42, the second elastic member 48, and the second fixing member 50. Have

The syringe barrel connection portion 52 is a portion connected to the syringe barrel 6 in which the liquid or gaseous medicine to be transferred is stored, and is located at the other end of the portion to which the first member 8 is connected. There is no particular limitation regarding the mechanism in which the syringe barrel connection portion 52 and the syringe barrel 6 are connected.

The female part 40 of the fitting mechanism is a female part of a fitting mechanism (locking mechanism) for connecting the first member 8 and the second member 38, and the male part 10 included in the first member 8 is connected to the female part 40. By fitting, the first member 8 and the second member 38 are connected by a simple operation. The fitting mechanism is, for example, a mechanism composed of a female part having a nail shape and a male part having a shape for hanging the nail, and the nail and the part to be hooked are engaged with each other. The one member 8 and the second member 38 can be easily connected and locked. The fitting mechanism may have other structures.

The second hollow needle member 42 has a hollow needle shape inside, the distal end portion 44 is disposed toward the first member 8 (first hollow needle portion 12), and the root portion 46 is connected to the syringe barrel 6. It arrange | positions toward the connection part (injection cylinder connection part 52). The distal end portion 44 is supported while being inserted into a second elastic member 48 described later, and the root portion 46 is fixed to the syringe barrel connection portion 52. Note that the first member 8 and the second member 38 are connected when the medicine is transferred, and the second hollow needle member 42 is inserted into the first hollow needle member 12. Therefore, the direction of the second hollow needle member 42 is fixed in a predetermined direction, and the connection operation between the members 8 and 38 (insertion operation of the hollow needle members 12 and 42) can be performed reliably and easily.

Further, since the drug solution is transferred between the drug container 2 and the syringe barrel 6 via the second hollow needle member 42, at least the tip 44 and the root 46 are provided with holes for drug transfer.

The second elastic member 48 is a spherical member made of a material having elasticity such as silicon or thermoplastic resin. The second elastic member 48 is fixed at a predetermined position in the second member 38 by the second fixing member 50. Here, the predetermined position means that when the first member 8 and the second member 38 are connected, the first elastic member 18 and the second elastic member 48 are applied with a predetermined force. It is a position to touch.

The second fixing member 50 is a member for fixing the second elastic member 48 to a predetermined position in the second member 38 as described above. The second fixing member 50 has a mortar shape with a hole in the bottom, and a second elastic member 48 having a spherical shape is fitted into the mortar-shaped portion, thereby providing a second elasticity. The member 48 is fixed at a predetermined position.

Next, the connection form of the first member 8 and the second member 38 will be described with reference to FIGS. 9 and 10. FIGS. 9 and 10 are cross-sectional views for explaining a connection mode of the first member 8 and the second member 38.

As shown in FIG. 9, as a first procedure, the male part 10 and the female part 40 of the fitting mechanism for connecting the first member 8 and the second member 38 are fitted together, The member 8 and the second member 38 are connected. In this state, the first elastic member 18 and the second elastic member 48 come into contact with each other, and the contact portions of the

elastic members

18 and 48 are crushed, and the first member 8 and the second elastic member 48 are brought into contact with each other. The connection part with the member 38 becomes a closed system closed from the outside.

Then, as shown in FIG. 10, as the second procedure, the distal end portion 44 of the second hollow needle member 42 supported by the second elastic member 48 is moved to the second procedure while maintaining the above state. The first elastic member 48 and the first elastic member 18 are pushed and penetrated through the first hollow needle member 12 through the root portion 16. At this time, since the second hollow needle member 42 may scrape the

elastic members

18 and 48, the first filter member 20 and the second filter member 24 prevent permeation of the shavings 54.

And the front-end | tip part 14 of the 1st hollow needle member 12 is inserted in the stopper 4 of the chemical | medical agent container 2, and a chemical | medical solution transfer between the chemical | medical agent container 2 and the injection cylinder 6 is performed via the

hollow needle members

12 and 42. .

Next, the third member 56 will be described with reference to FIG. As shown in FIG. 11, the third member 56 includes a female portion 58 of the second fitting mechanism, a pipe member 60, a third filter member 66, and a container pressure adjusting member 68.

The female portion 58 of the second fitting mechanism is a female portion of a fitting mechanism (locking mechanism) for connecting the first member 8 and the third member 56, and the male member included in the first member 8. By fitting in the part 30, the first member 8 and the second member 56 are detachably connected by a simple operation. The second fitting mechanism is, for example, a mechanism that includes a female part that has a claw shape and a male part that has a shape that hangs the claw, and the claw and the part that hangs the claw are engaged with each other. The first member 8 and the third member 56 can be easily connected and locked. The second fitting mechanism may have other structures.

The female portion 58 of the second fitting mechanism is disposed at the end portion 62 of the tube member 60. As shown in FIG. 11, the female portion 58 (end portion 62 of the tube member 60) of the second fitting mechanism has a hole by a plug when the first member 8 and the third member 56 are not connected. It is also possible to make the state closed.

The tube member 60 is a tubular member that allows the drug container 2 and the container pressure adjusting member 68 to communicate with each other. The tube member 60 includes a female portion 58 of the second fitting mechanism at one end 62 and the container pressure adjusting member 68 at the other end 64. The communication part is provided. The tube member 60 may be provided with a communication portion with the female portion 58 of the second fitting mechanism and the container pressure adjusting member 68 at a portion other than the end portion. The tube member 60 serves as a gas flow path in the drug container 2, but the drug in the drug container 2 may flow in.

The container pressure adjusting member 68 is a member that changes its own volume when the gas in the communicating medicine container 2 flows in, and as a result, uniformizes the pressure in the communicating medicine container 2 with the external pressure. The container pressure adjusting member 68 communicates with the drug container 2 via the tube member 60 connected to the end.

The container pressure adjusting member 68 may be a container having a bellows-like side surface, and its volume may be changed by expanding or contracting the bellows-shaped part. The container pressure adjusting member 68 is a soft bag-like container, and may be configured to be wound around the tube member 60 when not in use, or may have other shapes.

The third filter member 66 is a member having a function of allowing gas to pass but not allowing liquid (medicine) in the drug container 2 to pass (hard to allow liquid to pass). The third filter member 66 is disposed at an inlet site where the container pressure adjusting member 68 is communicated with the drug container 2 by the tube member 60.
(Usage method of drug transfer device according to this embodiment)
(1) About drug transfer operation

1, 2, 4, 6, 7, 9, and 10, the method of using the drug transfer device 1, specifically, the drug container in the drug transfer system 100 including the drug transfer device 1. 2. A method for transferring medicine between syringes 6 will be described. Here, it is assumed that the medicine is transported when the medicine container 2 is a vial as shown in FIG. 1, and the medicine is transported when the medicine container 2 is an infusion bag as shown in FIG.

As a first procedure, the operator inserts the distal end portion 14 of the first hollow needle member 12 included in the first member 8 shown in FIG. 2 and the first member 8 are connected.

As the second procedure, as shown in FIGS. 6 and 7, the operator adjusts the size of the drug container gripping portion 28 in accordance with the size of the diameter of the plug portion 4 of the drug container 2, and the plug portion The connection relationship between the drug container 2 and the first member 8 is fixed by sandwiching from the left and right sides or four sides of 4 (or the neck portion).

As a third procedure, as shown in FIG. 9, the operator fits the male part 10 and the female part 40 of the fitting mechanism and connects the first member 8 and the second member 38. In this state, the first elastic member 18 and the second elastic member 48 come into contact with each other, and the contact portions of the

elastic members

As the fourth procedure, the operator, as shown in FIG. 10, maintains the state where the third procedure is completed, and the second hollow needle member supported by the second elastic member 48. The distal end portion 44 of 42 is pushed and penetrated in the second elastic member 48 and the first elastic member 18. Further, the operator inserts the second hollow needle member 42 into the first hollow needle member 12 from the root portion 16. At this time, since the second hollow needle member 42 may scrape the

elastic members

18 and 48, the first filter member 20 and the second filter member 24 prevent permeation of the shavings 54.
As a fifth procedure, the operator connects the syringe barrel 6 to the syringe barrel connecting portion 52 provided in the second member 38 as shown in FIG. 1 or FIG.

As a sixth procedure, the operator transfers the drug from the syringe barrel 6 toward the drug container 2 or from the drug container 2 toward the syringe barrel 6. At that time, the operator transfers the medicine by inverting the medicine container 2 or appropriately operating the syringe barrel 6.
(2) Pressure equalization in the drug container

1, 2, and FIGS. 10 to 13, a method of using the drug transfer device 1, that is, a method of pressure equalizing operation in the drug container 2 in the drug transfer system 100 including the drug transfer device 1 will be described. Here, as shown in FIG. 1, drug transfer when the drug container 2 is a vial and drug transfer when the drug container 2 is an infusion bag as shown in FIG. 2 are assumed.

As the first procedure, the operator connects the first member 8 shown in FIG. 10 and the third member 56 shown in FIG. 11 to obtain the state of the medicine transfer device 1 shown in FIG. Specifically, the male part 30 of the second fitting mechanism provided in the first member 8 and the female part 58 of the second fitting mechanism provided in the third member 56 are fitted together, and the first member 8 is fitted. And the third member 56 are connected.

As the second procedure, as shown in FIG. 12, the operator uses the medicine transfer device 1 to which the first member 8, the second member 38, and the third member 56 are connected. The gas or liquid (drug, air, diluent, etc.) is transferred from the drug container 2 to the drug container 2 and mixed with the drug in the drug container 2. At this time, the gas (air) in the medicine container 2 flows into the container pressure adjusting member 68 through the third hollow needle member 32, the tube member 60, and the third filter member 66. Therefore, the pressure inside the medicine container 2 becomes substantially equal to the pressure outside the medicine container 2, and the risk of leakage or dripping of dangerous medicine from the stopper 4 of the medicine container 2 is reduced.

As a third procedure, as shown in FIG. 13, the operator moves the medicine in the medicine container 2 from the medicine container 2 to the syringe barrel 6 (collection) by inverting the vertical position of the medicine transportation system 100. To do. At this time, as shown in FIG. 13, the medicine in the medicine container 2 flows into the third hollow needle member 32 and the pipe member 60, but the end portion 64 of the pipe member 60 from the medicine liquid surface in the medicine container 2. Exists in the upper position, so that the medicine in the medicine container 2 does not enter the container pressure adjusting member 68.

Further, if the end portion 64 of the tube member 60 is arranged at the upper position from the bottom surface of the medicine container 2, the medicine enters the container pressure adjusting member 68 even if the amount of the medicine in the medicine container 2 increases. There is nothing. By doing so, in the medicine transfer device 1, the third filter member 66 is not wetted by the medicine, and the blockage of the gas flow path called a so-called air block does not occur.

On the other hand, even if the position of the drug liquid surface is close to the end portion 64 of the tube member 60, for example, when the end portion 64 of the tube member 60 exists below the bottom surface of the drug container 2, Since the three filter members 66 prevent the medicine from flowing into the container pressure adjusting member 68, the medicine does not enter the container pressure adjusting member 68.
(Summary)

The medicine transfer device 1 can reduce the risk of leakage and dripping of the medicine from the medicine container 2 when mixing the medicine by equalizing the pressure inside and outside the medicine container 2 by the third member 56. .

The medicine transfer device 1 can remove the instrument 56 for equalizing the pressure inside and outside the medicine container 2. Therefore, the medicine transfer device 1 may be attached to the instrument 56 only when it is necessary to equalize the pressure inside and outside the medicine container 2, and the operability during medicine transfer is improved.

Since the medicine transfer device 1 can remove the instrument 56 for equalizing the pressure inside and outside the medicine container 2, if the instrument 56 is not necessary, the medicine transfer apparatus 1 that does not include the instrument 56 can be manufactured and sold. The selling price can be reduced by reducing the manufacturing cost.

Although the embodiment of the present invention has been described in detail above, the present invention is not limited to the specific embodiment, and various modifications are possible within the scope of the gist of the present invention described in the claims.・ Change is possible.

1 Drug Transfer Device 2 Drug Container 4 Drug Container Cap 6 Syringe 8 First Member 10 Male Part 12 of Fitting Mechanism First Hollow Needle Member 14 First Hollow Needle Member Tip 16 First Hollow Needle Root portion 18 of member First elastic member 20 First filter member 22 Mesh member 24 Second filter member 26 First fixing member 28 Drug container gripping portion 30 Male portion 32 of second fitting mechanism First Three hollow needle members 34 A tip portion 36 of a third hollow needle member A root portion 38 of a third hollow needle member A second member 40 A female portion 42 of a fitting mechanism A second hollow needle member 44 A second hollow needle Member distal end portion 46 Second hollow needle member root portion 48 Second elastic member 50 Second fixing member 52 Syringe connecting portion 54 Unnecessary matter 56 Third member 58 Female portion of second fitting mechanism 60 Pipe member 62 One end of the pipe member 64 The other end of the pipe member 6 a third filter member 68 vessel pressure adjusting member 100 drug delivery system

Claims

The drug container and the injection, comprising: a first member connected to the stopper side of the drug container; and a second member connected to the first member at one end and connected to the syringe barrel at the other end. A drug transfer device that transfers a drug to and from a cylinder,
The first member is
A fitting mechanism for detachably connecting the first member and a third member connected to the first member and maintaining a constant pressure of the gas present in the drug container. Male part,
A tip portion is disposed toward the stopper side of the drug container, a root portion is disposed toward the second member side, and a hole for transporting the drug is provided in the root portion and the tip portion. A hollow needle member;
A third hollow needle member having a distal end portion disposed toward the stopper side of the drug container, a root portion disposed toward the third member side, and a vent hole provided in the root portion and the distal end portion; Have
The second member is
A second hollow needle having a distal end portion disposed toward the first member side, a root portion disposed toward the syringe barrel side, and a hole for transferring a drug to the root portion and the distal end portion Having a member,
When the first member and the second member are connected, the second hollow needle member is inserted into the first hollow needle member,
The first hollow member and the third hollow needle member are inserted through the stopper of the drug container,
The drug is transferred between the drug container and the syringe barrel via the first hollow needle member and the second hollow needle member inserted into the first hollow needle member. A medicine transfer device.
Having the third member;
The third member is
A female portion of the fitting mechanism;
A container pressure adjusting member whose internal volume changes according to a pressure difference with the drug container in communication;
A tube member that includes a female portion of the fitting mechanism at one end and communicates the container pressure adjusting member and the drug container at the other end;
The first member and the third member are detachably connected to each other by fitting the male part and the female part of the fitting mechanism. Drug transfer device.
3. The medicine transfer device according to claim 2, wherein the third member has a filter member that is disposed at the other end of the tube member and allows only gas to pass therethrough.
The said other end of the said tube member is located above the bottom face of the said medicine container when the stopper of the said medicine container is arrange | positioned down and the bottom face of this medicine container is arrange | positioned up. 2. The medicine transfer device according to 2.
3. The medicine transfer device according to claim 2, wherein the container pressure adjusting member is a bag-like member that can be wound around the tube member and can be expanded and contracted freely.
The medicine transfer device according to claim 1 or 2, wherein the third hollow needle member is included in the first hollow needle member.