WO2013140690A1 - Sonde de mesure et système de mesure bio-optique - Google Patents

Sonde de mesure et système de mesure bio-optique Download PDF

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Publication number
WO2013140690A1
WO2013140690A1 PCT/JP2012/082944 JP2012082944W WO2013140690A1 WO 2013140690 A1 WO2013140690 A1 WO 2013140690A1 JP 2012082944 W JP2012082944 W JP 2012082944W WO 2013140690 A1 WO2013140690 A1 WO 2013140690A1
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WO
WIPO (PCT)
Prior art keywords
optical
measurement
fiber
light
bio
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Application number
PCT/JP2012/082944
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English (en)
Japanese (ja)
Inventor
後野　和弘
至峰 小林
健二 上村
武志 菅
正弘 片倉
遼佑 伊藤
Original Assignee
オリンパスメディカルシステムズ株式会社
オリンパス株式会社
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Application filed by オリンパスメディカルシステムズ株式会社, オリンパス株式会社 filed Critical オリンパスメディカルシステムズ株式会社
Publication of WO2013140690A1 publication Critical patent/WO2013140690A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
    • A61B1/00167—Details of optical fibre bundles, e.g. shape or fibre distribution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/07—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres

Definitions

  • the present invention relates to a measurement probe used for optical measurement of biological tissue and a biological optical measurement system to which the measurement probe is connected.
  • a biological optical measurement apparatus that irradiates a living tissue with illumination light and estimates the properties of the living tissue based on the measurement value of the detection light reflected or scattered from the living tissue.
  • the bio-optical measurement device is used in combination with an endoscope for observing an organ such as a digestive organ.
  • an endoscope for observing an organ such as a digestive organ.
  • low coherence white light with a short spatial coherence length is irradiated onto the living tissue from the tip of the illumination fiber of the measurement probe, and the intensity distribution of scattered light at a plurality of angles is measured using a plurality of light receiving fibers.
  • a bio-optical measurement device using LEBS (Low-Coherence Enhanced Backscattering) that detects the properties of a living tissue by measurement is proposed (see Patent Document 1).
  • each of a plurality of optical fibers has to be arranged at an appropriate position.
  • the fiber bundle is different from the arrangement of the plurality of optical fibers on the end face of the proximal end portion and the arrangement of the plurality of optical fibers on the end face of the distal end portion.
  • the fiber bundle is a light guide.
  • the biological optical measurement system supplies the illumination light to the measurement probe described above and the measurement probe, and is a return light of the illumination light emitted from the measurement probe, which is reflected by the biological tissue. And / or an optical measurement device that receives scattered return light and performs optical measurement of the living tissue.
  • FIG. 1 is a block diagram schematically showing a configuration of a biological optical measurement system according to an embodiment of the present invention.
  • FIG. 2 is an enlarged schematic view of the main part of the measurement probe of the biological optical measurement system according to the embodiment of the present invention.
  • FIG. 3 is a block diagram schematically showing the configuration of the bio-optical measurement system according to the first modification of the embodiment of the present invention.
  • FIG. 4 is a block diagram schematically showing the configuration of the bio-optical measurement system according to the second modification of the embodiment of the present invention.
  • FIG. 1 is a block diagram schematically showing a configuration of a biological optical measurement system according to an embodiment of the present invention.
  • a bio-optical measurement system 1 shown in FIG. 1 includes a bio-optical measurement apparatus 2 that performs optical measurement on a measurement object such as a biological tissue that is a scatterer to detect the property (characteristic) of the measurement object, and bio-optics. And a measurement probe 3 for measurement that is detachably attached to the measurement apparatus 2 and is inserted into the subject.
  • the measurement object is a living tissue, blood flow, organ such as stomach or pancreas, mucous membrane, and the like.
  • the bio-optical measurement device 2 includes a power source 20, a light source unit 21, a light receiving unit 22, an input unit 23, an output unit 24, a recording unit 25, a connection unit 26, and a control unit 27.
  • the power supply 20 supplies power to each component of the biological optical measurement device 2.
  • the light source unit 21 supplies illumination light to the measurement probe 3 connected to the biological optical measurement device 2.
  • the light source unit 21 includes a light source 211 and an optical system 212.
  • the light source 211 is configured using an incoherent light source such as a white LED (Light Emitting Diode), a xenon lamp, a tungsten lamp, or a halogen lamp.
  • the light source 211 supplies incoherent light having at least one spectral component irradiated to the measurement object via the optical system 212 to an illumination fiber of the measurement probe 3 described later.
  • the optical system 212 transmits the illumination light irradiated by the light source 211 and the collimating lens 212a that collimates the illumination light irradiated by the light source 211, and from the measurement object received by the light receiving fiber of the measurement probe 3 described later.
  • a half mirror 212 b that reflects the return light to the light receiving unit 22, and a condenser lens 212 c that condenses the illumination light irradiated by the light source 211 at the emission position P ⁇ b> 1 from which the biological optical measurement device 2 exits.
  • the light receiving unit 22 receives and measures the light emitted from the measurement probe 3 and reflected and / or scattered by the measurement object.
  • the light receiving unit 22 includes a condenser lens 221 and an optical sensor unit 222.
  • the condensing lens 221 condenses the return light from the measurement probe 3 reflected by the half mirror 212 b of the light source unit 21 and emits it to the optical sensor unit 222.
  • the optical sensor unit 222 is configured using a detector, a spectroscope, or the like, and measures the spectral component and intensity distribution of the return light incident from the light receiving fiber of the measurement probe 3 via the condenser lens 221 to measure each wavelength. Measure.
  • the optical sensor unit 222 is appropriately provided according to the number of light receiving fibers of the measurement probe 3 described later.
  • the input unit 23 is realized by using a push-type switch, a keyboard, a touch panel, and the like, and receives an input of an activation signal for instructing activation of the biological optical measurement device 2 or an instruction signal for instructing various other operations, and is a control unit To 27.
  • the output unit 24 is realized by using a liquid crystal or organic EL (Electro Luminescence) display display, a speaker, and the like, and outputs information related to various processes in the biological optical measurement system 1.
  • a liquid crystal or organic EL (Electro Luminescence) display display a liquid crystal or organic EL (Electro Luminescence) display display, a speaker, and the like, and outputs information related to various processes in the biological optical measurement system 1.
  • the recording unit 25 is realized by using a volatile memory or a non-volatile memory, and records various programs for operating the biological optical measurement device 2, various data used for optical measurement processing, and various parameters.
  • the recording unit 25 temporarily records information being processed by the biological optical measurement device 2.
  • the recording unit 25 records the measurement result of the biological optical measurement device 2.
  • the recording unit 25 may be configured using a memory card or the like attached from the outside of the bio-optical measurement device 2.
  • connection part 26 is detachably connected to a connector part of the measurement probe 3 described later.
  • the connection unit 26 supplies illumination light emitted from the light source unit 21 to the measurement probe 3 and emits return light of the measurement object emitted from the measurement probe 3 to the light receiving unit 22.
  • the connection unit 26 outputs information related to whether or not the measurement probe 3 is connected to the control unit 27.
  • the control unit 27 is configured using a CPU (Central Processing Unit) or the like.
  • the control unit 27 controls the processing operation of each unit of the biological optical measurement device 2.
  • the control unit 27 controls the operation of the bio-optical measurement device 2 by transferring instruction information and data for each component of the bio-optical measurement device 2.
  • the control unit 27 records the measurement result by the light receiving unit 22 in the recording unit 25.
  • the control unit 27 includes a calculation unit 271.
  • the calculation unit 271 performs a plurality of calculation processes based on the measurement result by the light receiving unit 22 and calculates characteristic values related to the properties of the measurement object.
  • the type of the characteristic value is set according to an instruction signal received by the input unit 23, for example.
  • the measurement probe 3 is composed of a fiber bundle composed of a plurality of optical fibers.
  • the measurement probe 3 is configured using a light guide or a random fiber (excluding an image fiber) in which a plurality of optical fibers are irregularly bundled.
  • the light guide differs in the arrangement position (spatial arrangement) of each optical fiber between the end face of the base end portion of the fiber bundle and the end face of the tip end portion of the fiber bundle.
  • the measurement probe 3 is detachably connected to the connection portion 26 of the bio-optical measurement device 2, and includes a connector portion 31 that accommodates the proximal end portion 301a of the fiber bundle 300, a flexible portion 32 having flexibility, and a light source portion.
  • 21 has a distal end portion 33 that emits illumination light supplied from 21 and receives return light from the measurement object, and an optical element 34 that is detachably provided at the distal end portion 33.
  • FIG. 2 is an enlarged schematic view of the main part of the measurement probe 3.
  • the measurement probe 3 includes a fiber bundle 300.
  • the fiber bundle 300 includes an illumination fiber 311 that irradiates the measurement object with illumination light, a first light reception fiber 312 (first light reception channel) and a second light reception fiber 313 (return light from the measurement object that is incident at different angles.
  • the second light receiving channel) and the third light receiving fiber 314 and a plurality of other optical fibers 315 are irregularly bundled.
  • the illumination fiber 311, the first light receiving fiber 312, the second light receiving fiber 313, the third light receiving fiber 314, and the other optical fibers 315 are covered with a covering member 36 for light shielding and scratch prevention.
  • the measurement probe 3 has an illumination fiber 311, a first light receiving fiber 312, a second light receiving fiber 313, a third light beam at a position on the end surface 33 a of the distal end portion 33 and a position on the end surface 321 a of the proximal end portion 321.
  • the arrangement positions of the light receiving fiber 314 and the other optical fibers 315 are different.
  • the illumination light from the light source unit 21 is imaged on the end surface 33 a of the distal end portion 33 of the illumination fiber 311 in the measurement probe 3 through the optical system 212. Therefore, for example, even if the illumination light is imaged at the position of the optical fiber 315b shown in FIG.
  • a part of the illumination light irradiated from the optical fiber 315b is vignetted on the side surface 34b of the optical element 34.
  • the measurement probe 3 decreases the amount of light applied to the measurement object, and as a result, the signal quality (SN) also decreases.
  • the irradiation region R1 of the optical fiber 315 that relays and emits the illumination light emitted from the biological optical measurement device 2 and the irradiation region at the tip of the optical element 34
  • a base end portion 315a of the optical fiber 315 in which R1 is smaller than the area R2 of the end surface 34a at the tip end of the optical element 34 is disposed at a position P2 facing the emission position P1 of the illumination light in the biological optical measurement device 2 (see FIG. 1). reference).
  • the measurement probe 3 uses, as the illumination fiber 311, an optical fiber 315 disposed at a position P ⁇ b> 2 facing the emission position P ⁇ b> 1 where the illumination light in the biological optical measurement device 2 is collected and emitted to the outside.
  • the illumination fiber 311 has several numbers if the light incident from the biological optical measurement device 2 is emitted from the vicinity of the center of the end surface 33a of the fiber bundle 300 of the measurement probe 3 and is not vignetted by the side surface 34b of the optical element 34.
  • the position can be changed as appropriate.
  • the number and position of the illumination fibers 311 can be changed as appropriate according to the length of the optical element 34 if the side surfaces 34b of the optical element 34 are not vignetted.
  • the illumination fiber 311 propagates the illumination light supplied from the light source unit 21 and irradiates the measurement object with the illumination light via the optical element 34. Note that the number of illumination fibers 311 can be appropriately changed according to the inspection item and the type of measurement object, for example, blood flow, stomach, pancreas, or the like.
  • the optical element 34 is formed to be able to irradiate light in a state where the distance between the illumination fiber 311 and the measurement object is fixed and the spatial coherent length is reliably fixed.
  • the optical element 34 fixes the distance between the first light receiving fiber 312 and the measurement object, the distance between the second light receiving fiber 313 and the measurement object, and the distance between the third light receiving fiber 314 and the measurement object, respectively. It is formed so that return light having a scattering angle can be received stably.
  • the surface of the measurement object is flattened by the end face 34a of the optical element 34, the measurement object can be measured without being affected by the uneven shape of the surface of the measurement object.
  • the measurement probe 3 is inserted into the subject via the treatment instrument channel provided in the endoscope apparatus (endoscope scope) of the endoscope system, and illumination is performed.
  • the fiber 311 irradiates the measurement object with illumination light
  • the first light receiving fiber 312, the second light receiving fiber 313, and the third light receiving fiber 314 receive the return light from the measurement object, respectively, and receive the light from the bio-optical measurement device 2.
  • the calculation unit 271 measures the property of the measurement object based on the measurement result of the light receiving unit 22.
  • the irradiation region R1 of the optical fiber 315 emitted when the illumination light emitted by the biological optical measurement device 2 is relayed is optical.
  • a position P2 of the base end portion 315a of the optical fiber 315 in which the irradiation region R1 at the tip of the element 34 is smaller than the area R2 of the end face 34a of the tip of the optical element 34 is opposed to the illumination light emission position P1 in the bio-optical measurement device 2. Therefore, it is possible to accurately irradiate the measurement object with the illumination light without reducing the yield.
  • the spatial layout (arrangement) of optical fibers can be easily adjusted in order to obtain predetermined characteristics even if the measurement probe 3 is constituted by a fiber bundle.
  • the manufacturing cost can be greatly reduced.
  • the measurement probe 3 is composed of a general-purpose light guide, the manufacturing cost can be greatly reduced.
  • FIG. 3 is a block diagram schematically showing the configuration of the biological optical measurement system according to the first modification of the embodiment of the present invention.
  • symbol is attached
  • the bio-optical measurement system 100 shown in FIG. 3 includes a bio-optical measurement device 110 that performs optical measurement on a measurement object and detects the property of the measurement object, and the measurement probe 3.
  • the light source unit 111 supplies illumination light to the measurement probe 3 connected to the biological optical measurement device 110 via the optical fiber 111a.
  • the light source unit 111 is configured using a white LED.
  • the light source unit 111 emits incoherent light having at least one spectral component irradiated to the measurement object via the optical fiber 111a to the emission position P1, and supplies the incoherent light to the illumination fiber 311 of the measurement probe 3.
  • the light receiving unit 112 receives the return light from the measurement object, which is light emitted from the measurement probe 3 through the optical fiber 112a.
  • the light receiving unit 112 is configured using a spectroscope or the like.
  • the light receiving unit 112 outputs the measurement result to the control unit 27.
  • the measurement probe 3 is inserted into the subject via the treatment instrument channel provided in the endoscope apparatus of the endoscope system, and the light source is transmitted via the optical fiber 111a.
  • Illumination light irradiated by the unit 111 is supplied to the illumination fiber 311, the illumination fiber 311 irradiates the measurement object with illumination light, and the first light receiving fiber 312, the second light receiving fiber 313, and the third light receiving fiber 314 are measured.
  • the return light from the object is received and propagated to the light receiving unit 112 of the biological optical measurement device 110.
  • the calculation unit 271 measures the property of the measurement object based on the measurement result of the light receiving unit 1122.
  • the measurement probe 3 is an irradiation region R1 of the optical fiber 315 emitted when the illumination light emitted from the biological optical measurement device 110 is relayed among the plurality of optical fibers 315, and is irradiated at the tip of the optical element 34.
  • the base end portion 315a of the optical fiber 315 in which the region R1 is smaller than the area R2 of the end surface 34a at the tip end of the optical element 34 is disposed at a position P2 that faces the emission position P1 of the illumination light in the bio-optical measurement device 2.
  • the incident position P2 of the illumination light of the illumination fiber 311 in the fiber bundle 300 is easily set with respect to the emission position P1 of the illumination light emitted from the light source unit 111. Can match. Furthermore, the same effects as those of the above-described embodiment are obtained.
  • FIG. 4 is a block diagram schematically showing the configuration of the biological optical measurement system 200 according to the second modification of the embodiment of the present invention.
  • symbol is attached
  • the bio-optical measurement system 200 shown in FIG. 4 includes a bio-optical measurement device 210 that performs optical measurement on a measurement object and detects the property of the measurement object, and the measurement probe 3.
  • the bio-optical measurement device 210 includes a power source 20, an input unit 23, an output unit 24, a recording unit 25, a control unit 27, a light source unit 231, a light source unit 232, a half mirror 233, and a light receiving unit 244. .
  • the light source unit 231 supplies illumination light to the measurement probe 3 connected to the biological optical measurement device 210 via the half mirror 233 and the optical fiber 231a.
  • the light source unit 231 is configured using, for example, a blue LED.
  • the light source unit 231 supplies incoherent light having at least one spectral component that irradiates the measurement object via the optical fiber 231a to the emission position P1, thereby supplying the light to the illumination fiber 311 of the measurement probe 3.
  • the light source unit 232 supplies illumination light to the measurement probe 3 connected to the biological optical measurement device 210 via the half mirror 233 and the optical fiber 231a.
  • the light source unit 232 is configured using, for example, a green LED.
  • the light source unit 232 emits incoherent light having at least one spectral component to be irradiated onto the measurement object via the optical fiber 231a to the emission position P1, thereby supplying the illumination fiber 311 of the measurement probe 3.
  • the half mirror 233 transmits the illumination light emitted from the light source unit 231 and reflects the illumination light emitted from the light source unit 232 toward the connection unit 26.
  • the light receiving unit 234 receives the return light from the measurement object, which is the light emitted from the measurement probe 3 through the optical fiber 234a.
  • the light receiving unit 234 is configured using a spectroscope or the like.
  • the light receiving unit 234 outputs the measurement result to the control unit 27.
  • the measurement probe 3 is inserted into the subject via the treatment instrument channel provided in the endoscope apparatus of the endoscope system, and the light source is transmitted via the optical fiber 231a.
  • Illumination light emitted from the unit 231 and the light source unit 232 is supplied to the illumination fiber 311, and the illumination fiber 311 irradiates the measurement object with illumination light, and the first light receiving fiber 312, the second light receiving fiber 313, and the third light receiving fiber 314.
  • the calculation unit 271 measures the property of the measurement object based on the measurement result of the light receiving unit 234.
  • the measurement probe 3 is the irradiation region R1 of the optical fiber 315 that relays and emits the illumination light emitted from the biological optical measurement device 210 among the plurality of optical fibers 315, and the irradiation region at the tip of the optical element 34. Since the base end portion 315a of the optical fiber 315 in which R1 is smaller than the area R2 of the end surface 34a at the tip end of the optical element 34 is disposed at the position P2 facing the emission position P1 of the illumination light in the bio-optical measurement device 2, transmission characteristics In addition, the illumination fiber 311 can be easily aligned without reducing the yield.
  • the illumination light of the illumination fiber 311 in the fiber bundle 300 is incident on the emission position P1 of the illumination light emitted from the light source unit 231 and the light source unit 232.
  • the position P2 can be easily matched. Furthermore, the same effects as those of the above-described embodiment are obtained.
  • the return light having a specific wavelength region can be measured by controlling the lighting of the light source unit 232 according to the measurement object.
  • two light source units are provided, but three light source units (red LED, blue LED, green LED) may be provided. Accordingly, white illumination light can be supplied to the measurement probe 3, and return light having a specific wavelength range can be measured by controlling lighting of each light source unit.
  • a condensing lens and a collimating lens may be provided as appropriate.

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Abstract

L'invention concerne une sonde de mesure et un système de mesure bio-optique rendant possible d'irradier de façon précise un tissu vivant avec une lumière d'éclairage sans diminuer le rendement. L'invention concerne une sonde de mesure (3) comportant : un faisceau de fibres (300) constitué d'une pluralité de fibres optiques (315) regroupées ensemble en faisceau ; un élément optique (34) pour le maintien d'une distance constante entre un tissu biologique et une surface d'extrémité du faisceau de fibres (300), l'élément optique (34) étant disposé à la section d'extrémité distale du faisceau de fibres (300) ; et une section de connexion (31) pour recevoir la section d'extrémité proximale du faisceau de fibres (300), la section de connexion (31) étant connectée de façon détachable à un dispositif de mesure bio-optique pour fournir une lumière d'éclairage au tissu biologique et effectuer des mesures optiques, les sections (315a) d'extrémité proximale de ces fibres optiques (315) où une région d'irradiation des fibres optiques (315) à travers lesquelles la lumière d'éclairage émise par le dispositif de mesure bio-optique est transmise et émise, la région d'irradiation étant à l'extrémité distale de l'élément (34) optique, est plus petite que la région de surface de l'extrémité distale, étant disposées à une position faisant face à la position d'émission de la lumière d'éclairage dans le dispositif de mesure bio-optique.
PCT/JP2012/082944 2012-03-21 2012-12-19 Sonde de mesure et système de mesure bio-optique WO2013140690A1 (fr)

Applications Claiming Priority (2)

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US201261613657P 2012-03-21 2012-03-21
US61/613,657 2012-03-21

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004287172A (ja) * 2003-03-24 2004-10-14 Hitachi Metals Ltd 先球光ファイバ、コリメータ
JP2009537014A (ja) * 2006-05-12 2009-10-22 ノースウェスタン ユニバーシティ 低コヒーレンスの高められた後方散乱分光法のシステム、方法および装置

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004287172A (ja) * 2003-03-24 2004-10-14 Hitachi Metals Ltd 先球光ファイバ、コリメータ
JP2009537014A (ja) * 2006-05-12 2009-10-22 ノースウェスタン ユニバーシティ 低コヒーレンスの高められた後方散乱分光法のシステム、方法および装置

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