WO2013106458A3 - Filière de réacteur microfluidique - Google Patents

Filière de réacteur microfluidique Download PDF

Info

Publication number
WO2013106458A3
WO2013106458A3 PCT/US2013/020869 US2013020869W WO2013106458A3 WO 2013106458 A3 WO2013106458 A3 WO 2013106458A3 US 2013020869 W US2013020869 W US 2013020869W WO 2013106458 A3 WO2013106458 A3 WO 2013106458A3
Authority
WO
WIPO (PCT)
Prior art keywords
chamber
reactions
solid
organic matter
substrate
Prior art date
Application number
PCT/US2013/020869
Other languages
English (en)
Other versions
WO2013106458A2 (fr
Inventor
C. Frederick Battrell
John Clemmens
Isaac Sprague
Original Assignee
Micronics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/346,615 external-priority patent/US9056291B2/en
Application filed by Micronics, Inc. filed Critical Micronics, Inc.
Priority to CN201380011371.3A priority Critical patent/CN104136123B/zh
Priority to KR1020147018969A priority patent/KR102090934B1/ko
Priority to JP2014551425A priority patent/JP6190822B2/ja
Priority to EP13703175.3A priority patent/EP2802417B1/fr
Publication of WO2013106458A2 publication Critical patent/WO2013106458A2/fr
Publication of WO2013106458A3 publication Critical patent/WO2013106458A3/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/65—Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being directly submitted to a pulsating movement, e.g. by means of an oscillating piston or air column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/141—Preventing contamination, tampering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/021—Identification, e.g. bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/043—Hinged closures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0609—Holders integrated in container to position an object
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/14—Means for pressure control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0439—Moving fluids with specific forces or mechanical means specific forces vibrational forces ultrasonic vibrations, vibrating piezo elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Reciprocating Pumps (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

La présente invention a trait à un dispositif compact permettant de coupler de façon fonctionnelle un substrat plat solide, par exemple une lamelle de verre, à un circuit microfluidique et d'effectuer une ou des réactions sur une matière organique collée sur la face du substrat plat. Des réactions typiques incluent des réactions de fixation, de coloration et/ou de marquage. Lors de l'utilisation, une chambre de réaction hermétique est formée, la chambre renfermant la matière organique et au moins une partie du substrat solide. Un vide dans la chambre hermétique entre le substrat solide et généralement de dimensions microfluidiques et des éléments de pompe à membrane sont utilisés de manière à injecter, échanger et/ou mélanger les fluides dans la chambre.
PCT/US2013/020869 2012-01-09 2013-01-09 Filière de réacteur microfluidique WO2013106458A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201380011371.3A CN104136123B (zh) 2012-01-09 2013-01-09 微流体反应器系统
KR1020147018969A KR102090934B1 (ko) 2012-01-09 2013-01-09 마이크로유체 반응기 시스템
JP2014551425A JP6190822B2 (ja) 2012-01-09 2013-01-09 マイクロ流体リアクタシステム
EP13703175.3A EP2802417B1 (fr) 2012-01-09 2013-01-09 Système de réacteur microfluidique

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/346,615 2012-01-09
US13/346,615 US9056291B2 (en) 2005-11-30 2012-01-09 Microfluidic reactor system

Publications (2)

Publication Number Publication Date
WO2013106458A2 WO2013106458A2 (fr) 2013-07-18
WO2013106458A3 true WO2013106458A3 (fr) 2013-11-07

Family

ID=47678998

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/020869 WO2013106458A2 (fr) 2012-01-09 2013-01-09 Filière de réacteur microfluidique

Country Status (5)

Country Link
EP (1) EP2802417B1 (fr)
JP (1) JP6190822B2 (fr)
KR (1) KR102090934B1 (fr)
CN (1) CN104136123B (fr)
WO (1) WO2013106458A2 (fr)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3549674B1 (fr) 2012-12-21 2020-08-12 PerkinElmer Health Sciences, Inc. Films à faible élasticité pour utilisation micro-fluidique
WO2014100725A1 (fr) 2012-12-21 2014-06-26 Micronics, Inc. Système portable de détection par fluorescence et cartouche de microanalyse
US10065186B2 (en) 2012-12-21 2018-09-04 Micronics, Inc. Fluidic circuits and related manufacturing methods
EP2994750B1 (fr) 2013-05-07 2020-08-12 PerkinElmer Health Sciences, Inc. Dispositifs microfluidiques et méthodes de séparation du sérum et de compatibilité croisée du sang
JP6472788B2 (ja) 2013-05-07 2019-02-20 マイクロニクス， インコーポレイテッド 粘土鉱物およびアルカリ性溶液を使用して核酸含有試料を調製するための方法
JP6484222B2 (ja) 2013-05-07 2019-03-13 マイクロニクス， インコーポレイテッド 核酸の調製および分析のためのデバイス
DE102013220445B4 (de) * 2013-10-10 2016-04-07 Robert Bosch Gmbh Auslaufschutzeinheit für eine mikrofluidische Vorrichtung, mikrofluidische Vorrichtung, Verfahren zum Betreiben einer solchen Auslaufschutzeinheit und Verfahren zum Herstellen einer solchen Auslaufschutzeinheit
DE102013221525A1 (de) * 2013-10-23 2015-04-23 Robert Bosch Gmbh Analyseeinheit zur Durchführung einer Polymerase-Kettenreaktion, Analysevorrichtung, Verfahren zum Betrieb einer solchen Analyseeinheit und Verfahren zum Herstellen einer solchen Analyseeinheit
US10076751B2 (en) * 2013-12-30 2018-09-18 General Electric Company Systems and methods for reagent storage
US10634590B2 (en) * 2014-03-11 2020-04-28 Emd Millipore Corporation IHC, tissue slide fluid exchange disposable and system
EP2988872B1 (fr) * 2014-04-18 2018-06-13 Bio-rad Laboratories, Inc. Dispositifs microfluidiques pour dosages automatisés
WO2015175188A1 (fr) * 2014-05-14 2015-11-19 General Electric Company Ensembles de cuves à circulation microfluidique pour imagerie et procédé d'utilisation
WO2016031412A1 (fr) * 2014-08-25 2016-03-03 コニカミノルタ株式会社 Procédé de réaction, procédé de détection et dispositif de détection
CN104568557A (zh) * 2014-12-22 2015-04-29 珠海迪尔生物工程有限公司 一种用于固定玻片的夹具
US9878329B2 (en) * 2015-03-23 2018-01-30 SYFR, Inc. Self-contained slide receptacle for patient specimens
CN105214744A (zh) * 2015-10-26 2016-01-06 深圳华迈兴微医疗科技有限公司 一种磁微粒化学发光微流控芯片
EP3162229B1 (fr) 2015-10-28 2022-03-30 Fontem Holdings 1 B.V. Dispositif à fumer électronique avec un réservoir de liquide à volume variable
BR112018008386B1 (pt) * 2015-10-30 2023-01-24 Merck Patent Gmbh Dispositivo e conjunto de preparação de amostra
CN105424449A (zh) * 2015-11-11 2016-03-23 刘洋 一种用于切片染色的导流体结构及切片染色方法
US11504681B2 (en) 2016-02-19 2022-11-22 Perkinelmer Health Sciences, Inc. Microfluidic mixing device and method
CN105891049B (zh) * 2016-04-13 2018-11-23 青岛科技大学 一种研究流体流变行为的方法及狭缝流变仪
SG10202103252VA (en) 2016-09-30 2021-05-28 Tel Array Diagnostics Inc Microfluidic device
CN110573256B (zh) 2016-12-30 2022-09-02 罗氏血液诊断股份有限公司 样品处理系统及方法
WO2018183744A1 (fr) 2017-03-29 2018-10-04 The Research Foundation For The State University Of New York Dispositif microfluidique et procédés
CN107129930B (zh) * 2017-06-09 2019-11-26 北京百康芯生物科技有限公司 一种全集成核酸检测微流控芯片及其使用方法
CN107557452A (zh) * 2017-08-02 2018-01-09 南京岚煜生物科技有限公司 一种用于核酸扩增检测的微流控芯片
CN107606252B (zh) * 2017-08-02 2024-04-30 南京岚煜生物科技有限公司 用于微流控芯片的无源单向阀
GB2569344A (en) * 2017-12-14 2019-06-19 Randox Laboratories Ltd Fluidic card assembly
US10792594B2 (en) * 2017-12-28 2020-10-06 Replegin Corporation Dual pumping arrangement for a hollow fiber filter
DE102018200520A1 (de) * 2018-01-15 2019-07-18 Robert Bosch Gmbh Verfahren zum Bereitstellen einer Lösung der Substanz in einer mikrofluidischen Vorrichtung
JP6456530B1 (ja) * 2018-01-16 2019-01-23 株式会社アペレ 血液凝固時間測定用カートリッジ及び血液凝固時間測定装置
CN112946302B (zh) * 2018-01-16 2022-05-03 株式会社爱蓓儿 血液凝固时间测量用卡匣以及血液凝固时间测量装置
US20210031186A1 (en) * 2018-02-07 2021-02-04 The Trustees Of The University Of Pennsylvania High throughput microfluidic device
US10046322B1 (en) 2018-03-22 2018-08-14 Talis Biomedical Corporation Reaction well for assay device
EP3636344A1 (fr) * 2018-10-09 2020-04-15 Universiteit Maastricht Module de support d'échantillons
KR102151648B1 (ko) * 2018-12-03 2020-09-03 광운대학교 산학협력단 미세유체 접속 장치
EP3841386A4 (fr) * 2018-12-20 2021-10-20 Leica Biosystems Melbourne Pty Ltd Ensemble plateau de lames
CN109735430B (zh) * 2019-01-28 2021-12-14 武汉纺织大学 一种三维磁泳分离的微流控芯片
EP4010101A4 (fr) * 2019-08-05 2022-11-16 Repligen Corporation Dispositifs, systèmes et procédés de traitement continu avec écoulement tangentiel alternatif
WO2021030271A2 (fr) 2019-08-09 2021-02-18 Nutcracker Therapeutics, Inc. Procédés et appareils de fabrication permettant d'éliminer un matériau d'une composition thérapeutique
US11008627B2 (en) 2019-08-15 2021-05-18 Talis Biomedical Corporation Diagnostic system
CN110554184A (zh) * 2019-09-12 2019-12-10 深圳市科瑞达生物技术有限公司 一种化学发光微流控芯片
CN111214991A (zh) * 2020-01-13 2020-06-02 清华大学 一种高粘度液体常温自动混合装置
CN113275045A (zh) * 2020-02-20 2021-08-20 北京京东方健康科技有限公司 检测芯片及其操作方法、检测系统
CN111551752B (zh) * 2020-04-03 2021-10-08 深圳市科瑞达生物技术有限公司 一种化学发光免疫检测芯片及应用
CN111595836B (zh) * 2020-04-16 2022-09-30 四川轻化工大学 手持式气液相界面化学发光检测笔、装置、系统及其检测方法
CA3180301A1 (fr) * 2020-05-26 2021-12-02 Otto J. Prohaska Dispositifs et procedes de transfection
WO2021259497A1 (fr) * 2020-06-26 2021-12-30 Swissmeca Sa Puce microbiologique et dispositif de pompage
US20220062898A1 (en) * 2020-08-28 2022-03-03 Leica Microsystems Cms Gmbh Microfluidic Device for Image Multiplexing
GB2599357A (en) * 2020-09-21 2022-04-06 Quantumdx Group Ltd Microfluidic device with positive displacement pump
CN114113567A (zh) * 2020-11-26 2022-03-01 深圳市理邦精密仪器股份有限公司 分子诊断离心测试卡
CN112578111B (zh) * 2020-12-25 2024-06-18 扬州初心科技服务有限公司 一种食品抗生素蠕动多联免疫检测器
WO2022159570A1 (fr) * 2021-01-21 2022-07-28 Group K Diagnostics, Inc. Dispositifs microfluidiques et leur traitement rapide
CN113063780B (zh) * 2021-03-17 2023-11-03 长春长光辰英生物科学仪器有限公司 一种用于光学检测的拭子样品流体系统及其使用方法
GB2611290A (en) * 2021-09-23 2023-04-05 Genome Res Ltd Flow cell interface adaptor
CN115791763B (zh) * 2022-10-20 2023-11-14 胜泰生科(广州)医疗科技有限公司 均相发光检测装置及应用
EP4389265A1 (fr) * 2022-12-20 2024-06-26 1Drop Inc. Dispositif microfluidique monté avec un filtre à membrane avec sel fixé et appareil de montage de filtre à membrane
CN117625394A (zh) * 2023-12-01 2024-03-01 广东香勤生物科技有限公司 一种荔枝菌菌种培养液、制备方法及培养方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030129756A1 (en) * 2002-01-09 2003-07-10 Thorne Edward H. Slide cassette for fluidic injection
WO2005016529A1 (fr) * 2003-08-11 2005-02-24 Thinxxs Microtechnology Ag Cuve a circulation constituee de couches et de systemes de liaison
US20060003440A1 (en) * 2001-05-25 2006-01-05 Tecan Trading Ag Device and process unit for providing a hybridization chamber
WO2008002462A2 (fr) * 2006-06-23 2008-01-03 Micronics, Inc. Procédés et dispositifs destinés à des dosages immunologiques microfluidiques pratiqués au point de service

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4181650A (en) 1975-08-25 1980-01-01 Maier Charles L Jr Procedure for the assay of pharmacologically immunologically and biochemically active compounds in biological fluids
US4235960A (en) 1977-07-29 1980-11-25 The Medical College Of Wisconsin, Inc. Competitive enzyme-linked immunoassay
NL8000173A (nl) 1980-01-11 1981-08-03 Akzo Nv Toepassing van in water dispergeerbare, hydrofobe kleurstoffen als label in immunochemische testen.
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
CA1291031C (fr) 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Methode pour la detection de liants specifiques et des substances liables par ceux-ci
US4810630A (en) 1987-03-30 1989-03-07 E. I. Du Pont De Nemours And Company Use of polyoxyethylene ethers to improve the performance of immunoassays employing peroxidase conjugates
US4849340A (en) 1987-04-03 1989-07-18 Cardiovascular Diagnostics, Inc. Reaction system element and method for performing prothrombin time assay
US5100626A (en) 1990-05-24 1992-03-31 Levin Andrew E Binding assay device with removable cassette and manifold
US5415994A (en) 1993-08-02 1995-05-16 Quidel Corporation Lateral flow medical diagnostic assay device with sample extraction means
DE4332720C2 (de) 1993-09-25 1997-02-13 Karlsruhe Forschzent Mikromembranpumpe
US6287850B1 (en) 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
US5639428A (en) 1994-07-19 1997-06-17 Becton Dickinson And Company Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay
SE504193C2 (sv) 1995-04-21 1996-12-02 Hemocue Ab Kapillär mikrokyvett
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US6541213B1 (en) 1996-03-29 2003-04-01 University Of Washington Microscale diffusion immunoassay
US7052594B2 (en) 2002-01-31 2006-05-30 Sri International Devices and methods for controlling fluid flow using elastic sheet deflection
WO1999000655A2 (fr) 1997-06-27 1999-01-07 Immunetics, Inc. Appareil et procede d'essai de liaison rapide en ecoulement continu
US6037168A (en) 1997-12-31 2000-03-14 Cytonix Corporation Microbiological assembly comprising resealable closure means
SE9800070D0 (sv) 1998-01-14 1998-01-14 Hemocue Ab Blandningsmetod
US6158712A (en) 1998-10-16 2000-12-12 Agilent Technologies, Inc. Multilayer integrated assembly having an integral microminiature valve
WO2000063670A1 (fr) * 1999-04-20 2000-10-26 Cytologix Corporation Echange de fluides dans une chambre sur une lamelle de microscope
US6673620B1 (en) 1999-04-20 2004-01-06 Cytologix Corporation Fluid exchange in a chamber on a microscope slide
US6743399B1 (en) 1999-10-08 2004-06-01 Micronics, Inc. Pumpless microfluidics
US6272939B1 (en) 1999-10-15 2001-08-14 Applera Corporation System and method for filling a substrate with a liquid sample
US6569674B1 (en) 1999-12-15 2003-05-27 Amersham Biosciences Ab Method and apparatus for performing biological reactions on a substrate surface
US6309875B1 (en) 2000-02-29 2001-10-30 Agilent Technologies, Inc. Apparatus for biomolecular array hybridization facilitated by agitation during centrifuging
DE60141454D1 (de) 2000-03-14 2010-04-15 Micronics Inc Mikrofluid-analysekassette
WO2001070381A2 (fr) 2000-03-21 2001-09-27 Covaris, Inc. Procede et dispositif de regulation acoustique de solutions liquides dans des dispositifs microfluidiques
US6431212B1 (en) 2000-05-24 2002-08-13 Jon W. Hayenga Valve for use in microfluidic structures
US6581899B2 (en) 2000-06-23 2003-06-24 Micronics, Inc. Valve for use in microfluidic structures
ES2232407T3 (es) 2000-12-28 2005-06-01 F. Hoffmann-La Roche Ag Metodo para el procesado de una muestra de acido nucleico mediante la oscilacion de un segmento de una pared de un cartucho, un sistema y un cartucho para realizar dicho metodo.
CA2450676C (fr) 2001-03-09 2010-03-30 Biomicro Systems, Inc. Procede et systeme d'interfacage microfluidique avec des reseaux
WO2003015923A1 (fr) 2001-08-20 2003-02-27 Biomicro Systems, Inc. Melange de fluides dans des chambres a faible rapport de forme
US20020159920A1 (en) 2001-04-03 2002-10-31 Weigl Bernhard H. Multiple redundant microfluidic structures cross reference to related applications
US6729352B2 (en) 2001-06-07 2004-05-04 Nanostream, Inc. Microfluidic synthesis devices and methods
US7223371B2 (en) 2002-03-14 2007-05-29 Micronics, Inc. Microfluidic channel network device
US6843263B2 (en) 2002-06-24 2005-01-18 Industrial Technology Research Institute Partially closed microfluidic system and microfluidic driving method
US7419638B2 (en) 2003-01-14 2008-09-02 Micronics, Inc. Microfluidic devices for fluid manipulation and analysis
JP2006520190A (ja) 2003-01-21 2006-09-07 マイクロニクス， インコーポレイテッド 流体の微小流体的な操作、増幅、および分析（例えば、細菌アッセイおよびアンチグロブリン試験）のための方法およびシステム
US6916113B2 (en) 2003-05-16 2005-07-12 Agilent Technologies, Inc. Devices and methods for fluid mixing
DE10352716A1 (de) * 2003-11-05 2005-06-16 Einsle, Xaver Plattform
US7588890B2 (en) * 2004-04-16 2009-09-15 Wei-Sing Chu Device for extracting biological molecules from tissue specimens and methods for preparing the same
EP1614466A3 (fr) * 2004-07-08 2006-05-10 Tecan Trading AG Dispositif et procédé pour la prévention de bulles d'air dans une chambre d'hybridation
US7832429B2 (en) * 2004-10-13 2010-11-16 Rheonix, Inc. Microfluidic pump and valve structures and fabrication methods
US20060127886A1 (en) 2004-12-15 2006-06-15 Kaylor Rosann M Sample-efficient lateral flow immunoassay
US7763453B2 (en) 2005-11-30 2010-07-27 Micronics, Inc. Microfluidic mixing and analytic apparatus
US7906317B2 (en) 2007-10-21 2011-03-15 King Car Food Industrial Co., Ltd. Apparatus for thin-layer cell smear preparation and in-situ hybridization
EP2138233B1 (fr) * 2008-06-02 2010-10-20 Boehringer Ingelheim microParts GmbH Structure de feuille microliquide destinée au dosage de liquides
JP2010078508A (ja) * 2008-09-26 2010-04-08 Toshiba Corp 送液装置
WO2010040103A1 (fr) 2008-10-03 2010-04-08 Micronics, Inc. Appareil microfluidique et procédés d’exécution de détermination de groupe sanguin et épreuve de compatibilité croisée
US20110240127A1 (en) * 2010-04-02 2011-10-06 Integenx Inc. Fluidic Article Fabricated In One Piece

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060003440A1 (en) * 2001-05-25 2006-01-05 Tecan Trading Ag Device and process unit for providing a hybridization chamber
US20030129756A1 (en) * 2002-01-09 2003-07-10 Thorne Edward H. Slide cassette for fluidic injection
WO2005016529A1 (fr) * 2003-08-11 2005-02-24 Thinxxs Microtechnology Ag Cuve a circulation constituee de couches et de systemes de liaison
WO2008002462A2 (fr) * 2006-06-23 2008-01-03 Micronics, Inc. Procédés et dispositifs destinés à des dosages immunologiques microfluidiques pratiqués au point de service

Also Published As

Publication number Publication date
EP2802417B1 (fr) 2019-05-15
JP6190822B2 (ja) 2017-08-30
KR102090934B1 (ko) 2020-03-19
CN104136123B (zh) 2017-03-01
EP2802417A2 (fr) 2014-11-19
KR20140110925A (ko) 2014-09-17
CN104136123A (zh) 2014-11-05
WO2013106458A2 (fr) 2013-07-18
JP2015510111A (ja) 2015-04-02

Similar Documents

Publication Publication Date Title
WO2013106458A3 (fr) Filière de réacteur microfluidique
WO2013041713A3 (fr) Système et appareil pour réactions
WO2010091246A3 (fr) Conditionnement de liquide pouvant éclater et ses utilisations
CL2014002240A1 (es) Modulador del ligando de tipo delta 3 (dll3), particularmente un anticuerpo; ácido nucleico que lo codifica; célula huésped; conjugado de anticuerpo-fármaco antiproliferativo; uso para el tratamiento del cáncer; medicamento que lo comprende.
CL2009000853A1 (es) Composicion para tratar un fluido con contaminantes que comprende un compuesto insoluble que contiene tierras raras y un ligante polimerico; proceso para preparar la composicion mezclando los componentes y somenterlos a tratamiento mecanico, quimico termico para adherir el compuesto insoluble al ligante.
MX2021000416A (es) Substratos de metaloproteinasas de matriz y otras porciones escindibles y metodos para usar los mismos.
WO2013032834A3 (fr) Appareil de chromatographie pourvu d'un coupleur soudé par diffusion
MY159954A (en) Parallelized jet loop reactors.
WO2012044020A3 (fr) Composé d'oléfine cyclique, polymère photoréactif et couche d'alignement le contenant
BR112012027441A2 (pt) sistemas e métodos para fornecimento de um conjunto iv de droga perigosa de ventilação fechada
EP2781955A4 (fr) Procédé pour la fabrication d'un film d'alignement de carte-mère, plaque de transfert, et liquide d'alignement
WO2009069656A1 (fr) Micropuce et dispositif de surveillance du sang
WO2008030631A3 (fr) Dispositifs microfluidiques
IN2014DN08135A (fr)
WO2012170562A3 (fr) Interface fluidique
WO2012037184A3 (fr) Dispositif de mélange
WO2011163514A3 (fr) Déconstruction d'algues à l'aide de liquides ioniques
WO2012071472A3 (fr) Dispositifs microfluidiques multidirectionnels comprenant une zone de liaison à capture panoramique et leur procédé d'utilisation
MX2009008352A (es) Metodo para reacciones de intercambio de litio.
WO2012116335A3 (fr) Système couplé magnétiquement pour mélange
FR2974503B1 (fr) Composition de coloration mettant en oeuvre un coupleur 1-hydroxynaphtalenique et une base heterocyclique en milieu riche en corps gras, le procede de coloration et le dispositif
FR2988591B1 (fr) Composition de coloration mettant en oeuvre le (2,5-diaminophenyl)ethanol, un polymere cellulosique dans un milieu riche en corps gras, le procede de coloration et le dispositif
BR112013007376A2 (pt) método para alimentação de um composto antiestático a uma reação de polimerização.
WO2011112827A3 (fr) Marqueurs de surfaces cellulaires rares pour amplification
BRPI0913177A2 (pt) sistema de reação para realizar experimentos paralelos, e, divisor de escoamento.

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 13703175

Country of ref document: EP

Kind code of ref document: A2

ENP Entry into the national phase

Ref document number: 2014551425

Country of ref document: JP

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 20147018969

Country of ref document: KR

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2013703175

Country of ref document: EP