WO2013073245A1 - 生体計測装置、生体計測方法、プログラムおよび記録媒体 - Google Patents

生体計測装置、生体計測方法、プログラムおよび記録媒体 Download PDF

Info

Publication number
WO2013073245A1
WO2013073245A1 PCT/JP2012/071222 JP2012071222W WO2013073245A1 WO 2013073245 A1 WO2013073245 A1 WO 2013073245A1 JP 2012071222 W JP2012071222 W JP 2012071222W WO 2013073245 A1 WO2013073245 A1 WO 2013073245A1
Authority
WO
WIPO (PCT)
Prior art keywords
living body
light
fluorescence
excitation light
receiving unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2012/071222
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
佐藤　英雄
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sony Corp
Original Assignee
Sony Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sony Corp filed Critical Sony Corp
Priority to CN201280055118.3A priority Critical patent/CN103917859B/zh
Priority to US14/356,997 priority patent/US9888854B2/en
Publication of WO2013073245A1 publication Critical patent/WO2013073245A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0202—Mechanical elements; Supports for optical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0208—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using focussing or collimating elements, e.g. lenses or mirrors; performing aberration correction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/021—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using plane or convex mirrors, parallel phase plates, or particular reflectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/12—Generating the spectrum; Monochromators
    • G01J3/14—Generating the spectrum; Monochromators using refracting elements, e.g. prisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/30—Measuring the intensity of spectral lines directly on the spectrum itself
    • G01J3/36—Investigating two or more bands of a spectrum by separate detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/12—Generating the spectrum; Monochromators
    • G01J2003/1213—Filters in general, e.g. dichroic, band
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6421—Measuring at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6471—Special filters, filter wheel

Definitions

  • the present disclosure relates to a biological measurement apparatus, a biological measurement method, a program, and a recording medium.
  • the present disclosure proposes a new and improved living body measuring apparatus, living body measuring method, program, and recording medium capable of downsizing a living body measuring apparatus using fluorescence spectroscopy.
  • the light source unit that is disposed to face the first part of the surface of the living body and irradiates the first part with the excitation light, and adjacent to the first part of the surface of the living body
  • a living body including a light receiving portion that is disposed to face the second portion and that receives the fluorescence emitted from the second portion when the excitation light excites the first in-vivo substance of the living body.
  • a measuring device is provided.
  • the surface of the living body is generated by irradiating the first portion of the surface of the living body with the excitation light and the excitation light excites the first in-vivo substance of the living body. Receiving a fluorescence emitted from a second portion adjacent to the first portion.
  • a light source unit that is disposed to face the first part of the surface of the living body and that emits excitation light to the first part, and the first part of the surface of the living body
  • a light receiving portion that is disposed opposite to a second portion adjacent to the light receiving portion and receives the fluorescence generated by exciting the first internal substance of the living body and emitted from the second portion.
  • a program for realizing a function of controlling the light source unit and a function of controlling the light receiving unit is provided to a computer included in the living body measurement apparatus.
  • a light source unit that is disposed to face the first part of the surface of the living body and that emits excitation light to the first part, and the first part of the surface of the living body
  • a light receiving portion that is disposed opposite to a second portion adjacent to the light receiving portion and receives the fluorescence generated by exciting the first internal substance of the living body and emitted from the second portion.
  • a computer-readable recording medium recording a program for realizing a function of controlling the light source unit and a function of controlling the light receiving unit in a computer included in the living body measurement apparatus is provided.
  • the light source unit that is disposed to face the first portion of the surface of the living body and irradiates the excitation light in a direction inclined with respect to the surface of the living body, and the first of the surface of the living body.
  • the second surface adjacent to the first portion is disposed opposite to the second portion, and the excitation light is generated by exciting the first body substance of the living body and emitted from the second portion on the surface of the living body.
  • a living body measurement apparatus that includes a light receiving unit that receives fluorescence in a direction substantially perpendicular to the direction, and in which the direction in which the excitation light is irradiated is substantially orthogonal to the direction of the fluorescence.
  • the light source unit and the light receiving unit are disposed to face different parts of the surface of the living body. Therefore, the space between the light source unit and the light receiving unit and the surface of the living body may be small, and thus the apparatus can be miniaturized.
  • FIG. 1 is a diagram illustrating a configuration of a biological measurement apparatus according to a related technique of the embodiment of the present disclosure.
  • the living body measurement apparatus 10 includes a light source unit 11, a light receiving unit 12, and an analysis unit 13.
  • the biological measurement apparatus 10 is a biological measurement apparatus that performs biological measurement using fluorescence spectroscopy.
  • the light source unit 11 irradiates excitation light E toward the measurement target portion on the surface of the living body B.
  • the excitation light E incident on the living body B excites the in-vivo substance T in the living body B, whereby fluorescence F is generated from the in-vivo substance T.
  • the light receiving unit 12 receives the fluorescence F emitted from the measurement target portion.
  • the analysis unit 13 quantifies the in-vivo substance T by analyzing the spectrum and intensity of the fluorescence F received by the light receiving unit 12.
  • the living body measuring apparatus 10 In the living body measuring apparatus 10 described above, a certain amount of space is required between the light source unit 11 and the living body B so that the light source unit 11 can irradiate the entire measurement target portion of the surface of the living body B with the excitation light E. In addition, a certain amount of space is required between the light receiving unit 12 and the living body B so that the light receiving unit 12 can receive the fluorescence F from the entire measurement target portion on the surface of the living body B. As a result, the living body measuring apparatus 10 becomes large by the space between the light source unit 11 and the light receiving unit 12 and the living body B, and it is difficult to reduce the size.
  • the living body measuring apparatus 10 a part of the excitation light E irradiated from the light source unit 11 is reflected by the surface of the living body B and received by the light receiving unit 12 together with the fluorescence F. That is, the component of the excitation light E is mixed as noise in the analysis result of the fluorescence F. Since the difference in wavelength between the excitation light E and the fluorescence F is relatively small, it is difficult for the biological measurement apparatus 10 to separate and receive the excitation light E from the fluorescence F.
  • FIG. 2 is a diagram illustrating a configuration of the biological measurement apparatus according to the first embodiment of the present disclosure.
  • FIG. 3 is a diagram illustrating a configuration example of the light receiving unit of the biological measurement device according to the first embodiment of the present disclosure.
  • FIG. 4 is a diagram illustrating a configuration example of a filter according to the first embodiment of the present disclosure.
  • the living body measurement apparatus 100 includes a light source unit 110, a light shielding body 112, a light receiving unit 120, a filter 122, an analysis unit 130, and a control unit 140.
  • the biological measurement apparatus 100 is a biological measurement apparatus that performs biological measurement using fluorescence spectroscopy.
  • the light source unit 110 is disposed to face the first part on the surface of the living body B, and irradiates this part with the excitation light E.
  • the excitation light E is light for causing the in-vivo substance T of the living body B to be excited and releasing the fluorescence F. That is, the in-vivo substance T of the living body B becomes excited by absorbing the excitation light E, and then emits fluorescence F to return to the ground state.
  • the excitation light E for example, near-ultraviolet light or short-wavelength visible light is used. However, the present invention is not limited to this, and light having an arbitrary wavelength may be used as long as the substance can be in an excited state. Is possible.
  • the light source unit 110 for example, a light emitting diode (LED: Light Emitting Diode) or a small laser is used.
  • the light receiving unit 120 is disposed to face the second part on the surface of the living body B, and receives the fluorescence F emitted from this part.
  • the light receiving unit 120 converts the fluorescence F received using a photodetector (PD: Photo Detector) or the like into an electrical signal, and provides it to the analysis unit 130.
  • PD Photodetector
  • the 2nd part of the surface of the biological body B is a part adjacent to the 1st part by which said light source part 110 is arrange
  • the fluorescence F emitted from the second part is emitted from the in-vivo substance T of the living body B that has been excited by the excitation light E.
  • the light receiving unit 120 includes a two-dimensional spectrometer having a lens 1201, a slit 1203, a prism 1205, and an image sensor 1207.
  • the imaging element 1207 for example, a photodiode, or a two-dimensional image sensor such as a CCD (Charge Coupled Devices) type, a CMOS (Complementary Metal Oxide Semiconductor) type, or a TFT (Thin Film Transistor) type is used.
  • CCD Charge Coupled Devices
  • CMOS Complementary Metal Oxide Semiconductor
  • TFT Thin Film Transistor
  • the light guided by the lens 1201 and the slit 1203 is split by the prism 1205 and forms a two-dimensional image on the image sensor 1207 with one being the wavelength axis and the other being the viewing axis.
  • a change due to the position of the spectral component can be detected.
  • the living body B includes a portion where there are elements that affect the measurement result, such as surface hair, aza, mole, or arterial and venous blood vessels. In such a portion, the spectrum is considered to be discontinuous along the viewing axis. Therefore, according to the configuration of the light receiving unit 120 described above, such a portion can be detected as a singular point, and it is possible to select a measurement position by visual observation or acquire an average value by a plurality of measurements. Accurate measurement results can be obtained. In addition, the measurer may be notified by voice or display of whether or not the current measurement site is appropriate based on the flatness of the measurement amount thus measured.
  • the configuration of the light receiving unit 120 is not limited to the above example, and may be a configuration using a line sensor, for example.
  • the light receiving unit 120 may be provided with filters F1 to F6.
  • the filters F1 to F6 are narrowband filters that are divided in the direction of the wavelength axis of the image formed on the image sensor 1207, and are specialized for different wavelengths. Thereby, light of each wavelength can be individually measured in the wavelength axis direction.
  • the filters F1 to F6 may be narrowband filters such as RGB filters corresponding to the wavelength group to be searched. In this case, it is possible to omit the prism 1205, thereby reducing the size of the light receiving unit 120 and reducing the number of optical components used in the biological measurement apparatus 100.
  • the light source unit 110 and the light receiving unit 120 are arranged to face different portions on the surface of the living body B. That is, in the present embodiment, unlike the related art described above, the portion where the excitation light E is incident on the surface of the living body B is different from the portion where the fluorescence F to be measured is emitted.
  • Such a configuration is made possible by utilizing the property that the excitation light E is scattered after entering the inside of the living body B as shown in the figure.
  • the excitation light E incident from the first part of the surface of the living body B where the light source unit 110 is arranged is scattered inside the living body B and reaches, for example, a body substance T inside the second part.
  • the in-vivo substance T is excited and fluorescence F is emitted, and this fluorescence F is emitted from the second part of the surface of the living body B and received by the light receiving unit 120.
  • the light source unit 110 and the light receiving unit 120 need only enter the excitation light E or receive the fluorescence F for different parts of the surface of the living body B. There may be no space between the light source unit and the light receiving unit and the surface of the living body B. Therefore, the biological measurement apparatus 100 according to the present embodiment can be reduced in size as compared with the biological measurement apparatus 10 according to the related technology described above, for example.
  • the space between the light source unit 110 and the surface of the living body B can be eliminated, that is, the light source unit 110 can be disposed close to the surface of the living body B.
  • the efficiency of irradiation with the excitation light E can be improved.
  • the light receiving unit 120 can be disposed close to the surface of the living body. Thereby, the weak fluorescence emitted from the surface of the living body can be efficiently collected.
  • the light shield 112 is disposed between the light source unit 110 and the light receiving unit 120.
  • the light blocking body 112 prevents, for example, the excitation light E emitted from the light source unit 110 from being incident on the light receiving unit 120 side either directly or after being reflected from the surface of the living body B.
  • the portion irradiated with the excitation light E on the surface of the living body B is different from the portion from which the fluorescence F to be measured is emitted. It is possible to isolate the fluorescence F.
  • the excitation light E received by the light receiving unit 120 and affecting the analysis result of the fluorescence F is reduced, and the S / N (Signal / Noise) ratio is improved.
  • the analysis accuracy of the fluorescence F is improved. Can do.
  • the filter 122 is an optical filter disposed between the living body B and the light receiving unit 120.
  • the filter 122 can be, for example, a narrow-band bandpass filter that does not pass light of the wavelength of the excitation light E but passes light of the detection wavelength, that is, the wavelength of the fluorescence F.
  • the filter 122 for example, it is possible to prevent the excitation light E emitted from the surface of the living body B from being scattered inside the living body B and reaching the in-vivo substance T from being received by the light receiving unit 120. It is.
  • the excitation light E received by the light receiving unit 120 and affecting the analysis result of the fluorescence F is reduced, and the accuracy of the analysis of the fluorescence F can be improved.
  • the analysis unit 130 is realized by a computer having, for example, a CPU (Central Processing Unit), a RAM (Random Access Memory), a ROM (Read Only Memory), and the like.
  • the analysis unit 130 analyzes the spectrum and intensity of the fluorescence F based on the fluorescence F data acquired from the light receiving unit 120. Thereby, for example, the in-vivo substance T of the living body B that has released the fluorescence F can be quantified.
  • the analysis unit 130 may be a part of the biological measurement device 100 or may be an external device connected to the biological measurement device 100.
  • the imaging data of the fluorescence F generated by the light receiving unit 120 is stored in a removable storage medium, and the storage medium is removed from the biological measurement apparatus 100 and connected to another apparatus having the analysis unit 130. Fluorescence F may be analyzed.
  • the analysis unit 130 may execute an additional process suitable for measuring the in-vivo substance T of the living body B in the analysis of the fluorescence F.
  • the analysis unit 130 may separate the fluorescence emitted by the substance in the arterial blood from the received fluorescence F based on the same principle as the pulse oximeter. In this case, the analysis unit 130 separates, for example, the temporally changing component of the fluorescence F as being due to the pulse of the artery.
  • the control unit 140 is realized by a computer having a CPU, a RAM, a ROM, and the like, for example.
  • the control unit 140 controls the operation of each unit of the biological measurement apparatus 100 described above.
  • the control unit 140 controls the operations of the light source unit 110 and the light receiving unit 120 described above.
  • FIG. 5 is a diagram illustrating a configuration of a biological measurement apparatus according to the second embodiment of the present disclosure.
  • the biological measurement apparatus 200 includes a light source unit 210, a light shield 112, a light receiving unit 120, a filter 122, a diaphragm 224, an analysis unit 130, and a control unit 140.
  • a light source unit 210 a light shield 112
  • a light receiving unit 120 a light receiving unit 120
  • a filter 122 a diaphragm 224
  • an analysis unit 130 a control unit 140.
  • the diaphragm 224 is an optical member for limiting the directivity of light incident on the light receiving unit 120.
  • the diaphragm 224 selectively allows fluorescence F in a direction perpendicular to the living body B to enter the light receiving unit 120. Thereby, for example, mixing of the fluorescence F emitted from other than the measurement target portion can be prevented.
  • the optical member for limiting the directivity of the fluorescence F incident on the light receiving unit 120 is not limited to the diaphragm 224, and for example, a light shielding member may be used.
  • a microlens array may be provided.
  • the microlens array is, for example, a lens array in which a plurality of small light receiving lenses having a depth of field corresponding to the depth of the in-vivo substance T from the surface of the living body B are arranged in an array. The fluorescence F to be guided is guided.
  • FIG. 6 is a diagram illustrating a configuration of a biological measurement apparatus according to the third embodiment of the present disclosure.
  • the biological measurement apparatus 300 includes a light source unit 310, a light shield 112, a light receiving unit 120, a filter 122, an analysis unit 130, and a control unit 140.
  • a light source unit 310 since it is possible to set it as the structure similar to said 1st Embodiment except the light source part 310 among said components, detailed description is abbreviate
  • the light source unit 310 is disposed to face the first part on the surface of the living body B, and irradiates this part with the excitation light E.
  • the light source unit 310 irradiates the excitation light E using, for example, an LED.
  • the light source unit 310 irradiates the excitation light E in a direction inclined with respect to the surface of the living body B. More specifically, the light source unit 310 irradiates the excitation light E in a direction inclined toward the light receiving unit 120.
  • the light source unit 310 may include an optical system 3101 including one or a plurality of lenses, a diaphragm, and the like in order to give the irradiated excitation light E high directivity.
  • the light source unit 310 may include a light shield 3103 in order to prevent the excitation light E from leaking out.
  • Such a configuration is effective, for example, when the living body measuring apparatus 300 specializes in measuring the dermis layer B1 of the living body B.
  • the in-vivo substance T to be measured is in the dermis layer B1 close to the surface of the living body B.
  • the direction of irradiation of the excitation light E is inclined, and the excitation light E has directivity so that more excitation light E can be absorbed. It is effective to reach T.
  • the light receiving unit 120 when the light receiving unit 120 is configured to receive the fluorescence F in a direction substantially perpendicular to the surface of the living body B, the light source unit 310 is tilted to an extent substantially orthogonal to the direction of the fluorescence F.
  • the excitation light E may be irradiated in the direction.
  • FIG. 7 is a diagram illustrating a configuration of a biological measurement apparatus according to the fourth embodiment of the present disclosure.
  • the biological measurement apparatus 400 includes a light source unit 110, a light shield 112, a light receiving unit 120, a filter 122, a condensing prism 426, an analysis unit 130, and a control unit 140.
  • a light source unit 110 a light shield 112
  • a light receiving unit 120 a light receiving unit 120
  • a filter 122 a condensing prism 426
  • an analysis unit 130 a control unit 140.
  • these components can be configured in the same manner as in the second or third embodiment.
  • the condensing prism 426 condenses the fluorescence emitted from the living body onto the light receiving unit 120.
  • the condensing prism 426 collects the fluorescence F emitted from the second region on the surface of the living body B and guides it to the light receiving unit 120 as illustrated. Accordingly, it is not necessary to provide the light receiving unit 120 having a size over the entire second region. By reducing the size of the light receiving unit 120, the entire living body measurement apparatus 400 can also be reduced in size.
  • FIG. 8 is a diagram illustrating a configuration of a biological measurement apparatus according to the fifth embodiment of the present disclosure.
  • the living body measurement apparatus 500 includes a light source unit 510, a light shielding unit 112, a light receiving unit 120, a filter 122, an analysis unit 130, and a control unit 140.
  • a light source unit 510 since it is possible to set it as the structure similar to said 1st Embodiment except the light source part 510 among said components, detailed description is abbreviate
  • the light source unit 510 is disposed so as to face the first part on the surface of the living body B, and irradiates the part with light using, for example, an LED.
  • the light source unit 510 includes an excitation light E1 for exciting the in-vivo substance T1 of the living body B to emit fluorescence F, and an excitation light E1 for measuring the in-vivo substance T2 different from the in-vivo substance T1. Irradiate light E2 of different wavelengths in a time-sharing manner.
  • the light E2 may be light that excites the internal substance T2 to emit fluorescence, or may be light for measuring the internal substance T2 based on the light absorption rate.
  • the internal substance T2 can be, for example, a measurement disturbing substance for the internal substance T1.
  • the light source unit 510 emits light having a wavelength of 940 nm as the light E2.
  • the wavelength of the light E2 is a characteristic wavelength for light absorption by fat
  • the amount of fat inside the living body B can be measured using the light E2.
  • the light source unit 510 may irradiate light having a wavelength of 568 nm, 660 nm, or 890 nm as the light E2.
  • the wavelength of the light E2 is an absorption wavelength characteristic of oxyhemoglobin, it is possible to measure the degree to which the absorption by the blood inside the living body blocks the excitation light E1 using the light E2.
  • the light source unit 510 may irradiate light having a wavelength of 800 nm to 940 nm.
  • the wavelength of the light E2 is an absorption wavelength characteristic of reduced hemoglobin, it is possible to measure the influence of arterial blood components on fluorescence.
  • the light source unit 510 irradiates the excitation light E1 and the light E2 in a time-sharing manner, for example, measures the fluorescence F and the state of fat or blood that can be a measurement interfering substance for the fluorescence F.
  • the fluctuation of the measurement result due to the fluorescence F of the in-vivo substance T1 due to the fluctuation of the component can be appropriately corrected.
  • the light source unit 510 may irradiate the excitation light E1 for exciting the internal substance T1 and the light E2 that is excitation light for exciting the internal substance T2 in a time-sharing manner.
  • the excitation light E1 and the light E2 may be light having respective excitation wavelengths of the internal substance T1 and the internal substance T2.
  • the internal substance T1 and the internal substance T2 may both be substances to be measured. That is, in this case, it is possible to measure separately by exciting a plurality of mixed in-vivo substances T1 and T2 with excitation light corresponding to each of them and emitting fluorescence.
  • the size of the biological measurement apparatus can be reduced.
  • the size of the biological measurement device according to the related technology illustrated in FIG. 1 is several hundred cm 3
  • the size of the biological measurement device according to the embodiment of the present disclosure is small from several cm 3 to several tens cm 3. It is possible to
  • the irradiation power of the light source is ensured by securing the amount of excitation light sufficient to obtain sufficient fluorescence by arranging the light source unit that irradiates excitation light close to the surface of the living body. And power consumption can be reduced. This also makes it possible to reduce the influence of the excitation light on the human body when, for example, the excitation light is ultraviolet light.
  • the excitation light is diffused inside the living body and reaches the in-vivo substance, thereby reducing the excitation light reflected on the surface of the living body and mixed into the fluorescence. Accuracy can be improved.
  • a part irradiated with excitation light and a part from which fluorescence is emitted are separated on the surface of the living body, so that the wavelengths of the excitation light and fluorescence are close to each other, for example.
  • interference between excitation light and fluorescence near the surface of a living body can be reduced.
  • measurement fluctuations or errors due to physical differences in the living body are measured by irradiating the test light in a time-sharing manner with the excitation light and measuring the measurement interfering substances inside the living body. Can be reduced.
  • FIG. 9 is a block diagram for explaining a hardware configuration of the information processing apparatus 900 according to the embodiment of the present disclosure.
  • the information processing apparatus 900 mainly includes a CPU 901, a ROM 903, and a RAM 905.
  • the information processing apparatus 900 further includes a host bus 907, a bridge 909, an external bus 911, an interface 913, a sensor 914, an input device 915, an output device 917, a storage device 919, a drive 921, a connection port 923, and a communication device 925.
  • a host bus 907 mainly includes a CPU 901, a ROM 903, and a RAM 905.
  • the information processing apparatus 900 further includes a host bus 907, a bridge 909, an external bus 911, an interface 913, a sensor 914, an input device 915, an output device 917, a storage device 919, a drive 921, a connection port 923, and a communication device 925.
  • the CPU 901 functions as an arithmetic processing device and a control device, and controls all or a part of the operation in the information processing device 900 according to various programs recorded in the ROM 903, the RAM 905, the storage device 919, or the removable recording medium 927.
  • the ROM 903 stores programs used by the CPU 901, calculation parameters, and the like.
  • the RAM 905 primarily stores programs used by the CPU 901, parameters that change as appropriate during execution of the programs, and the like. These are connected to each other by a host bus 907 constituted by an internal bus such as a CPU bus.
  • the host bus 907 is connected to an external bus 911 such as a PCI (Peripheral Component Interconnect / Interface) bus via a bridge 909.
  • PCI Peripheral Component Interconnect / Interface
  • the sensor 914 is, for example, detection means for detecting biological information unique to the user or various information used for acquiring such biological information.
  • Examples of the sensor 914 include various image pickup devices such as a CCD (Charge Coupled Device) and a CMOS (Complementary Metal Oxide Semiconductor).
  • the sensor 914 may further include an optical system such as a lens and a light source used for imaging a living body part.
  • the sensor 914 may be a microphone or the like for acquiring sound or the like.
  • the sensor 914 may include various measuring devices such as a thermometer, an illuminometer, a hygrometer, a speedometer, and an accelerometer in addition to the above-described ones.
  • the input device 915 is an operation means operated by the user such as a mouse, a keyboard, a touch panel, a button, a switch, and a lever. Further, the input device 915 may be, for example, remote control means using infrared rays or other radio waves, or may be an external connection device 929 such as a mobile phone or a PDA that supports the operation of the information processing device 900. Good. Furthermore, the input device 915 includes an input control circuit that generates an input signal based on information input by a user using the above-described operation means and outputs the input signal to the CPU 901, for example. A user of the information processing apparatus 900 can input various data and instruct a processing operation to the information processing apparatus 900 by operating the input device 915.
  • the output device 917 is a device that can notify the user of the acquired information visually or audibly. Examples of such devices include CRT display devices, liquid crystal display devices, plasma display devices, EL display devices and display devices such as lamps, audio output devices such as speakers and headphones, printer devices, mobile phones, and facsimiles.
  • the output device 917 outputs results obtained by various processes performed by the information processing apparatus 900. Specifically, the display device displays the results obtained by various processes performed by the information processing device 900 as text or images.
  • the audio output device converts an audio signal composed of reproduced audio data, acoustic data, and the like into an analog signal and outputs the analog signal.
  • the storage device 919 is a data storage device configured as an example of a storage unit of the information processing device 900.
  • the storage device 919 includes, for example, a magnetic storage device such as an HDD (Hard Disk Drive), a semiconductor storage device, an optical storage device, or a magneto-optical storage device.
  • the storage device 919 stores programs executed by the CPU 901, various data, various data acquired from the outside, and the like.
  • the drive 921 is a reader / writer for a recording medium, and is built in or externally attached to the information processing apparatus 900.
  • the drive 921 reads information recorded on a removable recording medium 927 such as a mounted magnetic disk, optical disk, magneto-optical disk, or semiconductor memory, and outputs the information to the RAM 905.
  • the drive 921 can write a record on a removable recording medium 927 such as a magnetic disk, an optical disk, a magneto-optical disk, or a semiconductor memory.
  • the removable recording medium 927 is, for example, a DVD medium, an HD-DVD medium, a Blu-ray medium, or the like.
  • the removable recording medium 927 may be a compact flash (registered trademark) (CompactFlash: CF), a flash memory, or an SD memory card (Secure Digital memory card). Further, the removable recording medium 927 may be, for example, an IC card (Integrated Circuit card) on which a non-contact IC chip is mounted, an electronic device, or the like.
  • CompactFlash CompactFlash: CF
  • flash memory a flash memory
  • SD memory card Secure Digital memory card
  • the removable recording medium 927 may be, for example, an IC card (Integrated Circuit card) on which a non-contact IC chip is mounted, an electronic device, or the like.
  • the connection port 923 is a port for directly connecting a device to the information processing apparatus 900.
  • Examples of the connection port 923 include a USB (Universal Serial Bus) port, an IEEE 1394 port, a SCSI (Small Computer System Interface) port, and the like.
  • As another example of the connection port 923 there are an RS-232C port, an optical audio terminal, an HDMI (High-Definition Multimedia Interface) port, and the like.
  • the communication device 925 is a communication interface configured with, for example, a communication device for connecting to the communication network 931.
  • the communication device 925 is, for example, a communication card for a wired or wireless LAN (Local Area Network), Bluetooth (registered trademark), or WUSB (Wireless USB).
  • the communication device 925 may be a router for optical communication, a router for ADSL (Asymmetric Digital Subscriber Line), or a modem for various communication.
  • the communication device 925 can transmit and receive signals and the like according to a predetermined protocol such as TCP / IP, for example, with the Internet or other communication devices.
  • the communication network 931 connected to the communication device 925 is configured by a wired or wireless network, and may be, for example, the Internet, a home LAN, infrared communication, radio wave communication, satellite communication, or the like. .
  • each component described above may be configured using a general-purpose member, or may be configured by hardware specialized for the function of each component. Therefore, it is possible to change the hardware configuration to be used as appropriate according to the technical level at the time of carrying out this embodiment.
  • a light source unit disposed opposite to the first part of the surface of the living body and irradiating the first part with excitation light; Disposed from a second portion adjacent to the first portion of the surface of the living body, and generated when the excitation light excites the first body substance of the living body and emitted from the second portion.
  • a biological measurement apparatus comprising: a light receiving unit that receives the fluorescent light.
  • the light receiving unit receives the fluorescence in a direction substantially perpendicular to the surface of the living body, The biological measurement apparatus according to (2), wherein a direction in which the excitation light is irradiated is substantially orthogonal to the direction of the fluorescence.
  • the living body measurement apparatus according to any one of (1) to (3) further including an optical member that controls directivity of light incident on the light receiving unit.
  • (5) further comprising a lens array in which a plurality of light receiving lenses having a depth of field corresponding to the depth of the first body substance from the surface of the living body are arranged in an array, The biological measurement apparatus according to any one of (1) to (4), wherein the fluorescence incident on the light receiving unit is guided by the lens array.
  • the living body measurement apparatus according to any one of (1) to (5), further including a light blocking body disposed between the light source unit and the light receiving unit.
  • the light source unit is different from the excitation light for the first portion and the excitation light for measuring a second in-vivo substance different from the first in-vivo substance of the living body.
  • the living body measurement apparatus according to any one of (1) to (6), wherein light with a wavelength is irradiated in a time division manner.
  • the light receiving unit includes a two-dimensional spectrometer.
  • the living body measurement apparatus according to any one of (1) to (8), further including a condensing unit that collects the fluorescence and guides the fluorescence to the light receiving unit.
  • a condensing unit that collects the fluorescence and guides the fluorescence to the light receiving unit.
  • (10) irradiating the first portion of the surface of the living body with excitation light; Receiving the fluorescence emitted from the second part adjacent to the first part of the surface of the living body generated by the excitation light exciting the first in-vivo substance of the living body.
  • a light source unit disposed opposite to the first part of the surface of the living body and irradiating the first part with excitation light, and a second adjacent to the first part of the surface of the living body And a light receiving unit that receives fluorescence emitted from the second part generated by exciting the first in-vivo substance of the living body.
  • a function of controlling the light source unit A program for realizing the function of controlling the light receiving unit.
  • a light source unit disposed opposite to the first part of the surface of the living body and irradiating the first part with excitation light, and a second adjacent to the first part of the surface of the living body And a light receiving unit that receives fluorescence emitted from the second part generated by exciting the first in-vivo substance of the living body.
  • a function of controlling the light source unit A computer-readable recording medium having recorded thereon a program for realizing the function of controlling the light receiving unit.
  • a light source unit that is disposed to face the first portion of the surface of the living body and that emits excitation light in a direction inclined with respect to the surface of the living body; Disposed from a second portion adjacent to the first portion of the surface of the living body, and generated when the excitation light excites the first body substance of the living body and emitted from the second portion.
  • a light receiving portion for receiving fluorescence in a direction substantially perpendicular to the surface of the living body, The biological measurement apparatus in which the direction in which the excitation light is irradiated is substantially orthogonal to the direction of the fluorescence.

Landscapes

  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
PCT/JP2012/071222 2011-11-16 2012-08-22 生体計測装置、生体計測方法、プログラムおよび記録媒体 Ceased WO2013073245A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201280055118.3A CN103917859B (zh) 2011-11-16 2012-08-22 生物计量设备、生物计量方法、程序和记录介质
US14/356,997 US9888854B2 (en) 2011-11-16 2012-08-22 Biometric device, biometric method, program, and recording medium

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011-250997 2011-11-16
JP2011250997A JP5970785B2 (ja) 2011-11-16 2011-11-16 生体計測装置、生体計測方法、プログラムおよび記録媒体

Publications (1)

Publication Number Publication Date
WO2013073245A1 true WO2013073245A1 (ja) 2013-05-23

Family

ID=48429326

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2012/071222 Ceased WO2013073245A1 (ja) 2011-11-16 2012-08-22 生体計測装置、生体計測方法、プログラムおよび記録媒体

Country Status (4)

Country Link
US (1) US9888854B2 (https=)
JP (1) JP5970785B2 (https=)
CN (1) CN103917859B (https=)
WO (1) WO2013073245A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11077294B2 (en) 2013-03-13 2021-08-03 Tc1 Llc Sheath assembly for catheter pump
US12491354B2 (en) 2012-05-14 2025-12-09 Tc1 Llc Sheath system for catheter pump
US12551688B2 (en) 2014-04-15 2026-02-17 Tc1 Llc Heart pump providing adjustable outflow
US12569668B2 (en) 2012-05-14 2026-03-10 Tc1 Llc Impeller for catheter pump

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105307559B (zh) 2013-06-06 2020-06-05 普罗菲尤萨股份有限公司 用于探测来自植入传感器的光信号的设备和方法
US10048130B2 (en) * 2015-01-09 2018-08-14 California Institute Of Technology Context imaging raman spectrometer
KR101789053B1 (ko) * 2015-06-29 2017-10-23 연세대학교 산학협력단 프렛 효과를 이용하는 안압계
CN105044079B (zh) * 2015-07-23 2018-03-13 中国石油天然气股份有限公司 一种有机质裂解的方法及装置
FR3048071B1 (fr) * 2016-02-23 2018-04-06 Tcm Dispositif d'eclairage pour dispositif de prise de teinte d'une dent, dispositif de prise de teinte integrant ledit dispositif d'eclairage
CN106525816A (zh) * 2016-12-08 2017-03-22 同方威视技术股份有限公司 非接触式安全检查系统及方法
CN114176522A (zh) * 2021-12-09 2022-03-15 武汉资联虹康科技股份有限公司 一种通道可灵活配置的近红外脑功能成像系统
CN114403810A (zh) * 2022-01-24 2022-04-29 武汉资联虹康科技股份有限公司 一种基于物联网的智能头戴式近红外脑功能成像系统

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1137938A (ja) * 1997-07-22 1999-02-12 Shimadzu Corp 拡散反射光計測装置
JP2004344668A (ja) * 2003-05-21 2004-12-09 Asulab Sa 有機組織の表面を照射する装置を含む生理学的数値を測定するための携帯式計測器
JP2005227155A (ja) * 2004-02-13 2005-08-25 Nara Institute Of Science & Technology 生体組織測定用イメージセンサ及び該センサを用いた生体組織測定方法
JP2006112839A (ja) * 2004-10-13 2006-04-27 Hitachi High-Technologies Corp 電気泳動装置
JP2008538312A (ja) * 2005-04-19 2008-10-23 ドイチェス クレブスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェンレヒツ デュアルモダリティイメージングシステムおよび方法
JP2011097986A (ja) * 2009-11-04 2011-05-19 Olympus Corp 光スペクトル検出方法
JP2011525629A (ja) * 2008-06-24 2011-09-22 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ マイクロアレイ評価システム及び方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3819032B2 (ja) * 1995-08-24 2006-09-06 ザ・テキサス・エイ・アンド・エム・ユニバーシティ・システム 組織およびその他のランダム媒体における蛍光寿命に基づく撮像および分光分析
US6124597A (en) * 1997-07-07 2000-09-26 Cedars-Sinai Medical Center Method and devices for laser induced fluorescence attenuation spectroscopy
US6721582B2 (en) * 1999-04-06 2004-04-13 Argose, Inc. Non-invasive tissue glucose level monitoring
DK1217943T3 (da) * 1999-09-30 2009-08-17 Diagnoptics Holding B V Fremgangsmåde og apparat til bestemmelse af autofluorescens af hudvæv
US8581697B2 (en) 2001-04-11 2013-11-12 Trutouch Technologies Inc. Apparatuses for noninvasive determination of in vivo alcohol concentration using raman spectroscopy
US7139598B2 (en) 2002-04-04 2006-11-21 Veralight, Inc. Determination of a measure of a glycation end-product or disease state using tissue fluorescence
US20030125630A1 (en) * 2001-12-31 2003-07-03 Furnish Simon M. Catheter probe arrangement for tissue analysis by radiant energy delivery and radiant energy collection
CN2549460Y (zh) * 2002-06-09 2003-05-07 浙江大学 一种生物芯片分析仪
US7130042B2 (en) * 2003-03-06 2006-10-31 Board Of Trustees Of The Leland Stanford Junior University Dual axis fluorescence microscope with modulated input
JP5006215B2 (ja) * 2006-02-07 2012-08-22 古河電気工業株式会社 光検出装置及び測定対象読取装置
US20090080194A1 (en) * 2006-02-15 2009-03-26 Li-Cor, Inc. Fluorescence filtering system and method for molecular imaging
JP4711009B2 (ja) * 2008-10-16 2011-06-29 ソニー株式会社 光学的測定装置
CN101906384B (zh) * 2009-06-03 2013-03-27 中国科学院电子学研究所 一种细菌流动计数检测的仪表装置和方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1137938A (ja) * 1997-07-22 1999-02-12 Shimadzu Corp 拡散反射光計測装置
JP2004344668A (ja) * 2003-05-21 2004-12-09 Asulab Sa 有機組織の表面を照射する装置を含む生理学的数値を測定するための携帯式計測器
JP2005227155A (ja) * 2004-02-13 2005-08-25 Nara Institute Of Science & Technology 生体組織測定用イメージセンサ及び該センサを用いた生体組織測定方法
JP2006112839A (ja) * 2004-10-13 2006-04-27 Hitachi High-Technologies Corp 電気泳動装置
JP2008538312A (ja) * 2005-04-19 2008-10-23 ドイチェス クレブスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェンレヒツ デュアルモダリティイメージングシステムおよび方法
JP2011525629A (ja) * 2008-06-24 2011-09-22 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ マイクロアレイ評価システム及び方法
JP2011097986A (ja) * 2009-11-04 2011-05-19 Olympus Corp 光スペクトル検出方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KIYOTAKA SASAGAWA ET AL.: "Implantable CMOS image sensors for monitoring brain activities", FUNCTION & MATERIALS, vol. 31, no. 2, 5 January 2011 (2011-01-05), pages 24 - 32 *
SASAGAWA K ET AL.: "Implantable Image Sensor with Light Guide Array Plate for Bioimaging", JAPANESE JOURNAL OF APPLIED PHYSICS, vol. 49, no. 4, ISS, 25 April 2010 (2010-04-25), pages 04DL03.1 - 04DL03.5 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12491354B2 (en) 2012-05-14 2025-12-09 Tc1 Llc Sheath system for catheter pump
US12569668B2 (en) 2012-05-14 2026-03-10 Tc1 Llc Impeller for catheter pump
US11077294B2 (en) 2013-03-13 2021-08-03 Tc1 Llc Sheath assembly for catheter pump
US11964119B2 (en) 2013-03-13 2024-04-23 Tc1 Llc Sheath assembly for catheter pump
US12551688B2 (en) 2014-04-15 2026-02-17 Tc1 Llc Heart pump providing adjustable outflow

Also Published As

Publication number Publication date
US9888854B2 (en) 2018-02-13
JP2013104851A (ja) 2013-05-30
US20140296668A1 (en) 2014-10-02
CN103917859A (zh) 2014-07-09
CN103917859B (zh) 2018-04-13
JP5970785B2 (ja) 2016-08-17

Similar Documents

Publication Publication Date Title
JP5970785B2 (ja) 生体計測装置、生体計測方法、プログラムおよび記録媒体
US10085656B2 (en) Measurement device, measurement method, program and recording medium
US9924874B2 (en) Measurement device, measurement method, program and recording medium
JP6539877B2 (ja) 測定装置、測定方法、プログラム及び記録媒体
JP6539876B2 (ja) 測定装置、測定方法、プログラム及び記録媒体
CN103987316B (zh) 测量设备、测量方法
JP2013118978A (ja) 測定装置、測定方法、プログラム及び記録媒体
CN106092996B (zh) 一种基于自体荧光寿命的癌症诊断系统
TW201310019A (zh) 光體積變化訊號之光學成像裝置及其光學量測方法
JP5990906B2 (ja) 測定装置、測定方法、プログラムおよび記録媒体
US11096586B1 (en) Systems for detecting carious lesions in teeth using short-wave infrared light
JP6010898B2 (ja) 生体計測装置、生体計測方法、プログラムおよび記録媒体
JP2022545163A (ja) 帯域外波長の改善された光拒絶のための光学フィルタ素子、システム及び方法
TWI907306B (zh) 複合波長光源的血糖偵測模組及其穿戴裝置
JP3180988U (ja) Ｐｐｇ信号を測定する光学撮像装置

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12850129

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 14356997

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 12850129

Country of ref document: EP

Kind code of ref document: A1