WO2013072770A3 - Formulations pharmaceutiques comprenant de l'atorvastatine et du glimépiride - Google Patents

Formulations pharmaceutiques comprenant de l'atorvastatine et du glimépiride Download PDF

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Publication number
WO2013072770A3
WO2013072770A3 PCT/IB2012/002860 IB2012002860W WO2013072770A3 WO 2013072770 A3 WO2013072770 A3 WO 2013072770A3 IB 2012002860 W IB2012002860 W IB 2012002860W WO 2013072770 A3 WO2013072770 A3 WO 2013072770A3
Authority
WO
WIPO (PCT)
Prior art keywords
glimepiride
atorvastatin
pharmaceutical formulations
pharmaceutically acceptable
acceptable salts
Prior art date
Application number
PCT/IB2012/002860
Other languages
English (en)
Other versions
WO2013072770A2 (fr
Inventor
Maheshwar KOLLURI
Rajesh Dubey
Rajeev Singh Raghuvanshi
Original Assignee
Dr. Reddy's Laboratories Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr. Reddy's Laboratories Ltd. filed Critical Dr. Reddy's Laboratories Ltd.
Priority to RU2014124118/15A priority Critical patent/RU2014124118A/ru
Priority to EP12826534.5A priority patent/EP2779999A2/fr
Priority to IN4119CHN2014 priority patent/IN2014CN04119A/en
Publication of WO2013072770A2 publication Critical patent/WO2013072770A2/fr
Publication of WO2013072770A3 publication Critical patent/WO2013072770A3/fr
Priority to ZA2014/03735A priority patent/ZA201403735B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Selon certains aspects, la présente invention concerne des formulations pharmaceutiques comprenant de l'atorvastatine ou des sels pharmaceutiquement acceptables de celle-ci, et du glimépiride en tant qu'agents actifs, à la fois l'atorvastatine ou des sels pharmaceutiquement acceptables de celle-ci et le glimépiride étant sous une forme à libération immédiate.
PCT/IB2012/002860 2011-11-15 2012-11-14 Formulations pharmaceutiques comprenant de l'atorvastatine et du glimépiride WO2013072770A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
RU2014124118/15A RU2014124118A (ru) 2011-11-15 2012-11-14 Фармацевтические препараты, включающие аторвастатин и глимепирид
EP12826534.5A EP2779999A2 (fr) 2011-11-15 2012-11-14 Formulations pharmaceutiques comprenant de l'atorvastatine et du glimépiride
IN4119CHN2014 IN2014CN04119A (fr) 2011-11-15 2012-11-14
ZA2014/03735A ZA201403735B (en) 2011-11-15 2014-05-22 Pharmaceutical formulations comprising atorvastatin and glimepiride

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN3920/CHE/2011 2011-11-15
IN3920CH2011 2011-11-15
US201261582566P 2012-01-03 2012-01-03
US61/582,566 2012-01-03

Publications (2)

Publication Number Publication Date
WO2013072770A2 WO2013072770A2 (fr) 2013-05-23
WO2013072770A3 true WO2013072770A3 (fr) 2013-10-24

Family

ID=48430284

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2012/002860 WO2013072770A2 (fr) 2011-11-15 2012-11-14 Formulations pharmaceutiques comprenant de l'atorvastatine et du glimépiride

Country Status (5)

Country Link
EP (1) EP2779999A2 (fr)
IN (1) IN2014CN04119A (fr)
RU (1) RU2014124118A (fr)
WO (1) WO2013072770A2 (fr)
ZA (1) ZA201403735B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230181532A1 (en) * 2020-05-18 2023-06-15 Board Of Regents, The University Of Texas System Granules for 3d printing technology
CN112618499B (zh) * 2020-12-24 2022-09-30 石药集团欧意药业有限公司 一种格列美脲分散片剂组合物及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004110431A1 (fr) * 2003-06-12 2004-12-23 Warner-Lambert Company Llc Compositions stables d'atorvastatine preparees par granulation par voie humide
WO2007072218A2 (fr) * 2005-06-10 2007-06-28 Combino Pharm, S.L. Formulations contenant du glimepiride et/ou ses sels
CN101103990A (zh) * 2006-07-14 2008-01-16 北京华安佛医药研究中心有限公司 含有磺脲类降糖药物和他汀类降脂药物的组合物
WO2009140341A2 (fr) * 2008-05-13 2009-11-19 Dr. Reddy's Laboratories Ltd. Compositions d'atorvastatine

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DE2951135A1 (de) 1979-12-19 1981-06-25 Hoechst Ag, 6230 Frankfurt Sulfonylharnstoffe, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
DE3320582A1 (de) 1983-06-08 1984-12-13 Dr. Karl Thomae Gmbh, 7950 Biberach Gliquidonhaltige zubereitungsformen und verfahren zu ihrer herstellung
US4681893A (en) 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
EP0680320B1 (fr) 1993-01-19 1999-04-14 Warner-Lambert Company Formulation ci-981, orale, stable et son procede de preparation
ES2167587T3 (es) 1995-07-17 2002-05-16 Warner Lambert Co Forma cristalina de la sal hemicalcica del acido (r-(r*,r*))-2-(4-fluorofenil)-beta,delta-dihidroxi-5-(1-metiletil)-3-fenil-4-((fenilamino)carbonil)-1h-pirrol-1-heptanoico (atorvastatina).
SI20109A (sl) 1998-12-16 2000-06-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Stabilna farmacevtska formulacija
GB0001662D0 (en) 1999-02-06 2000-03-15 Zeneca Ltd Pharmaceutical compositions
ES2401598T3 (es) 2000-04-10 2013-04-22 Teva Pharmaceutical Industries, Ltd. Composiciones farmacéuticas estables que contienen ácidos 7-sustituido-3,5-dihidroxiheptanoicos o ácidos 7-sustituido-3,5-dihidroxiheptenoicos
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Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004110431A1 (fr) * 2003-06-12 2004-12-23 Warner-Lambert Company Llc Compositions stables d'atorvastatine preparees par granulation par voie humide
WO2007072218A2 (fr) * 2005-06-10 2007-06-28 Combino Pharm, S.L. Formulations contenant du glimepiride et/ou ses sels
CN101103990A (zh) * 2006-07-14 2008-01-16 北京华安佛医药研究中心有限公司 含有磺脲类降糖药物和他汀类降脂药物的组合物
WO2009140341A2 (fr) * 2008-05-13 2009-11-19 Dr. Reddy's Laboratories Ltd. Compositions d'atorvastatine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHOWDHURY S ET AL: "Statistical optimization of fixed dose combination of glimepiride and atorvastatin calcium in immediate release tablet Formulation", INTERNATIONAL JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES : IJPPS, MADHYA PRADESH, IN, vol. 2, no. Suppl. 4, 1 November 2010 (2010-11-01), pages 194 - 200, XP008163345, ISSN: 0975-1491 *
DATABASE WPI Week 200874, Derwent World Patents Index; AN 2008-M50691, XP002700007 *

Also Published As

Publication number Publication date
IN2014CN04119A (fr) 2015-07-10
WO2013072770A2 (fr) 2013-05-23
EP2779999A2 (fr) 2014-09-24
RU2014124118A (ru) 2015-12-27
ZA201403735B (en) 2015-12-23

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