Classifications

• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
  • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
  • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2

Definitions

• This invention relates to bioeides. More especially the invention relates to the tetramethylammonium salt of l ,2-benzisothiazolin-3-one.
• l ,2-benzisothiazolin-3-one sometimes referred to hereinafter as BIT is a well-known biocide which is used inter alia in paint and in water cooling systems.
• BIT itself is not very water soluble. While it can be used either as a suspension or as a solution in an organic solvent neither option is especially favourable. In the case of suspensions settling can occur leading to difficulties in dosage.
• the problems of using solutions based on volatile organic solvents are well known. It has been proposed to use salts of BIT.
• tetramethylammonium salt of BIT hereinafter referred to as "tetramethylammonium BIT”.
• tetramethylammonium BIT tetramethylammonium BIT
• tetramethylammonium BIT which corresponds to 40wt% BIT and have a freezing point of 3°C after storage for 24 hours and seeding with solid tetramethylammonium BIT. It has known been very surprisingly found that the reported freezing point is not correct and that water solutions of tetramethylammonium BIT are stable at much lower temperatures than hitherto realised.
• a composition consisting essentially of water and the tetramethylammonium salt of l ,2-benzisothiazolin-3-one having a freezing point of less than about 0°C, such as less than about -1 °C for example less than about -3°C, about-5°C, about -10°C, about -15°C, about -20°C, about -25°C or - 30°C.
• freezing point means that the composition is fluid after 24 hours and seeded with solid tetramethylammonium salt of l ,2-benzisothiazolin-3- one.
• water-mi scible organic solvent examples can include aliphatic alcohols having 1 to 4 carbon atoms such as ethanol and isopropanol.
• glycols such as ethylene glycol, diethylene glycol. 1 .2-propylene glycol, dipropylene glycol and tripropylene glycol, glycol ethers such as butyl glycol and butyl digylcol, glycol esters such as 2,2,4-trimethylpentanediol monoisobutyrate, polyethylene glycol, polypropylene glycol, ⁇ , ⁇ -dimethylformamide and mixtures thereof.
• Preferably less than about 5wt% water-miscible organic solvent is used but higher concentration for example up to about 10wt%, 15wt% or about 20wt% can be used if necessary.
• the pH of the composition is generally neutral or slightly alkaline for example about 8 to about 10.
• biocide composition of the invention can also contain other customary constituents known as additives to those skilled in the art in the field of biocides. These are, e.g., thickening agents, defoaming agents, substances to adjust the pH value, perfumes, dispersing agents, and coloring substances.
• the biocide composition of the invention can be used in many different fields. It is suitable, for example, for use in paints, plasters, lignosulfonates, chalk suspensions, adhesives, photochemicals, casein-containing products, starch-containing products, bituminous emulsions, surfactant solutions, motor fuels, cleaning agents, cosmetic products, water circulating systems, polymer dispersions, and cooling lubricants, against attack by, for example, bacteria, filamentous fungi, yeasts, and algae.
• the biocide composition can be used either as a ready-to-use mixture or by adding the biocides and the remaining components of the composition separately to the substance to be preserved.
• composition consisting essentially of water and the tetramethylammonium salt of 1 ,2-benzisothiazolin-3-one ' may mean a solution containing not more than about 5wt% of ingredients other than water and the tetramethylammonium salt of l ,2-benzisothiazolin-3-one.
• Tetramethylammonium BIT can he prepared as described in WO 02 14 293 by reacting tetramethylammonium hydroxide solution with BIT. While solid
• tetramethylammonium pentahydrate is known it is very expensive and practically it is necessary to use the much cheaper water solution. This is typically available as 5 to 25wt% solutions. Reaction of 25wt% tetramethylammonium hydroxide with BIT gives rise to a 39wt% solution containing the equivalent of 26wt% BIT. If more concentrated solutions (up to about 40wt% BIT) are required water can be evaporated from the solution. The pure compound can be obtained by dehydration under reduced pressure. If more dilute solutions are required then more dilute tetramethylammonium hydroxide can be used or the prepared solution can be diluted.
• the solution should have a BIT content of more than about 5wt%, such as about 10wt% or about 15wt%.
• Commercial solutions of sodium BIT contain about 20wt% BIT and so concentrations of this order are very useful since no reformulation is required. More concentrated solutions such as about 25wt% or about 30wt% or about 35wt% or about 40wt% such as 42.6wt% or 43wt% may also be useful.

Landscapes

• Life Sciences & Earth Sciences (AREA)
• Agronomy & Crop Science (AREA)
• Pest Control & Pesticides (AREA)
• Plant Pathology (AREA)
• Health & Medical Sciences (AREA)
• Engineering & Computer Science (AREA)
• Dentistry (AREA)
• General Health & Medical Sciences (AREA)
• Wood Science & Technology (AREA)
• Zoology (AREA)
• Environmental Sciences (AREA)
• Agricultural Chemicals And Associated Chemicals (AREA)
• Thiazole And Isothizaole Compounds (AREA)

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• 2011
  • 2011-10-27 US US13/282,508 patent/US8466184B2/en active Active
• 2012
  • 2012-02-02 CN CN201280000204.4A patent/CN103209590B/zh active Active
  • 2012-02-02 IN IN835KON2014 patent/IN2014KN00835A/en unknown
  • 2012-02-02 MX MX2014004956A patent/MX367692B/es active IP Right Grant
  • 2012-02-02 WO PCT/EP2012/051787 patent/WO2013060485A1/en not_active Ceased
  • 2012-02-02 JP JP2014537521A patent/JP2014530886A/ja active Pending
  • 2012-02-02 EP EP12701913.1A patent/EP2770833B1/en active Active
  • 2012-05-22 BR BR102012012232-4A patent/BR102012012232A2/pt not_active Application Discontinuation

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