WO2013060067A1 - 膜式渗透汽化式固定人工生物瓣的方法及装置 - Google Patents
膜式渗透汽化式固定人工生物瓣的方法及装置 Download PDFInfo
- Publication number
- WO2013060067A1 WO2013060067A1 PCT/CN2011/084056 CN2011084056W WO2013060067A1 WO 2013060067 A1 WO2013060067 A1 WO 2013060067A1 CN 2011084056 W CN2011084056 W CN 2011084056W WO 2013060067 A1 WO2013060067 A1 WO 2013060067A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- reaction chamber
- pervaporation
- reaction
- fixed
- membrane
- Prior art date
Links
- 239000012528 membrane Substances 0.000 title claims abstract description 62
- 238000000034 method Methods 0.000 title claims abstract description 46
- 238000005373 pervaporation Methods 0.000 title claims abstract description 43
- 238000006243 chemical reaction Methods 0.000 claims abstract description 83
- 239000007788 liquid Substances 0.000 claims abstract description 37
- 238000011144 upstream manufacturing Methods 0.000 claims abstract description 10
- 239000012466 permeate Substances 0.000 claims abstract description 5
- 238000003756 stirring Methods 0.000 claims description 43
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 26
- 239000012295 chemical reaction liquid Substances 0.000 claims description 23
- 230000008569 process Effects 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 8
- 230000008016 vaporization Effects 0.000 claims description 6
- 238000009834 vaporization Methods 0.000 claims description 5
- 239000012510 hollow fiber Substances 0.000 claims description 3
- 230000003213 activating effect Effects 0.000 abstract 2
- 239000000376 reactant Substances 0.000 abstract 2
- 210000004379 membrane Anatomy 0.000 description 38
- 239000000126 substance Substances 0.000 description 11
- 238000007385 chemical modification Methods 0.000 description 10
- 239000002904 solvent Substances 0.000 description 7
- 102000008186 Collagen Human genes 0.000 description 5
- 108010035532 Collagen Proteins 0.000 description 5
- 229920001436 collagen Polymers 0.000 description 5
- 239000000835 fiber Substances 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 238000004132 cross linking Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000003100 immobilizing effect Effects 0.000 description 3
- 239000003607 modifier Substances 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 125000003172 aldehyde group Chemical group 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 208000037805 labour Diseases 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2415—Manufacturing methods
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/36—Pervaporation; Membrane distillation; Liquid permeation
- B01D61/362—Pervaporation
- B01D61/3621—Pervaporation comprising multiple pervaporation steps
Definitions
- the present invention relates to a device for immobilizing an artificial biological valve.
- the invention also relates to a method of immobilizing an artificial bioprosthetic valve. Background technique
- glutaraldehyde is a classical fixed crosslinking agent, which is widely used in the tanning and preservation of various artificial biological valve materials.
- the current common method for immobilizing artificial flaps is the common chemical solvent method in which artificial biological valves are chemically reacted in a liquid environment.
- glutaraldehyde has side effects, that is, the free aldehyde group produced by glutaraldehyde has a cytotoxic effect, causing loss of a large amount of tissue matrix while causing aging of artificial biological valves, changing its biomechanical properties, resulting in postoperative labor.
- the biological valve is declining.
- the current improvement in the decline of artificial bioprostheses caused by the above reasons is mainly through screening for more suitable concentrations of glutaraldehyde, treatment time and cross-linking fixed pressure.
- the intra-tissue pressure at the time of cross-linking can affect the internal configuration of the artificial biological valve leaf, damage the collagen structure, and even cause the collagen fiber to disintegrate, thereby affecting the life and durability of the artificial biological valve. Therefore, zero or low pressure fixation should be used as much as possible, and elastic valve holders should be used to ensure the integrity of the blade tissue of the artificial biological valve and reduce the stress damage. Poor durability is the most important weakness of artificial biological valves, so improving the durability of artificial biological valves is the fundamental direction of developing biological valves.
- the present invention provides a method and apparatus for membrane pervaporation-fixed artificial biological flaps to overcome the above-mentioned drawbacks of the prior art.
- the invention provides a membrane pervaporation fixed artificial biological valve device, comprising a liquid storage tank for storing a reaction liquid, a reaction chamber, a fixing fixture for fixing the artificial biological valve, a pervaporation membrane module and a vacuum pump.
- the fixing fixture is positioned inside the reaction chamber; the pervaporation membrane module is positioned inside the reaction chamber and located upstream of the fixing fixture; the liquid storage tank is connected to the reaction chamber upstream of the reaction chamber; the vacuum pump is in the reaction chamber The downstream is connected to the reaction chamber.
- the apparatus of the present invention further includes a frame, the liquid reservoir, the reaction chamber and the vacuum pump are both fixed to the frame, wherein the vacuum pump can be fixed to the bottom of the frame.
- the pervaporation membrane module comprises one or more of a flat pervaporation membrane module, a hollow fiber pervaporation membrane module, and a roll pervaporation membrane module.
- the apparatus of the present invention further comprises: a stirring motor, a stirring rod and a stirring blade, the stirring rod is fixed to an end of the stirring motor; and the stirring blade is fixed to the stirring rod.
- the stirring rod and the stirring blade are driven by the stirring motor to agitate the reaction liquid in the liquid storage tank, so that the concentration of the reaction liquid in the liquid storage tank is kept uniform.
- the agitating motor can be fixed above the frame.
- the apparatus of the present invention further includes a rotating disk fixed to the end of the rotating electrical machine and located inside the reaction chamber, and a rotating electric machine fixed to the rotating disk.
- the chemical modification reaction is made more uniform by adjusting the rotational speed of the rotating disk by a rotary motor.
- the rotating electrical machine can be fixed to the top of the frame.
- the apparatus of the present invention further includes a heating module assembly that is respectively fixed to the periphery of the liquid storage tank and the reaction chamber to promote vaporization of the reaction liquid.
- the apparatus of the present invention further comprises a gas-liquid separator and a raffinate tank, the gas-liquid separator being connected to the reaction chamber downstream of the reaction chamber and then connected to a vacuum pump for separating the reaction liquid and the air leaving the reaction chamber Separating for further processing; the raffinate tank is connected to the reaction chamber below the pervaporation membrane module to collect the residual solution after the reaction.
- the present invention provides a method for membrane-type pervaporation-fixed artificial bioprosthesis using the above apparatus, comprising the steps of: fixing one end of an artificial bioprosthesis to a membrane pervaporation-fixed artificial bioprosthetic device of the present invention On the fixing fixture, the other end is free to sag; the vacuum pump is turned on; the pervaporation membrane module is opened, so that the vaporized reaction liquid enters the reaction chamber and permeates through the pervaporation membrane module to reach the artificial biological valve; and the artificial biological valve is reacted in the reaction chamber for a certain period of time.
- the reaction solution includes a glutaraldehyde solution.
- the method of the present invention further comprises the steps of: turning on the stirring motor, driving the stirring rod and the stirring blade to agitate the reaction liquid in the liquid storage tank, so that the reaction liquid in the liquid storage tank Concentration Storage Uniformity
- the method of the present invention further comprises the steps of: turning on the rotating electrical machine.
- the chemical modification reaction is made more uniform by adjusting the rotational speed of the rotating disk by a rotary motor.
- the method of the present invention further comprises the step of: turning on the heating module assembly to promote vaporization of the reaction liquid.
- the process parameters of the membrane pervaporation type immobilization artificial bioprosthesis according to the present invention are as follows: membrane module permeation rate is 20 to 180 g / (m 2 * hour); reaction chamber pressure is 0 to 5000 Pa The concentration of the glutaraldehyde solution is 0.5 to 50% ; the rotation speed of the stirring rod is 0 to 200 rpm; and the rotation speed of the rotating disk is 0 to 200 rpm.
- the device and method of the invention ensure the artificial organism by ensuring that the glutaraldehyde monomer enters the reaction region of the artificial biological valve at a constant rate by using the membrane pervaporation method, and at the same time, the reaction region of the artificial biological valve is in a low pressure environment.
- the valve is in a reaction zone containing a constant concentration of glutaraldehyde and a low pressure environment during the chemical modification process.
- the device and the method of the invention not only accelerate the chemical modification treatment time of the artificial biological valve, but also enable the artificial biological valve to maintain the collagen fiber texture structure of the artificial biological valve better in the chemical modification process, thereby improving the artificial organism.
- the overall durability of the flap Moreover, according to the apparatus and method of the present invention, the artificial biological valve undergoes a chemical reaction in a gaseous environment, the chemical reaction is more permeable, and the reaction rate and efficiency are higher.
- FIG. 1 is a schematic view showing the structure of a membrane type pervaporation-fixed artificial biological valve of the present invention. List of reference signs
- the membrane pervaporation type fixed artificial biological valve device of the present invention comprises a frame 1, a stirring motor 2, a stirring rod 3, a stirring blade 4, a heating module assembly 5, 10, a rotating electric machine 6, a residual liquid.
- the reaction chamber and the liquid storage tank 15 are both fixed to the frame 1; the liquid storage tank 15 is connected to the reaction chamber 13 upstream of the reaction chamber 13; the stirring motor 2 is fixed above the frame 1; The stirring rod 3 is fixed to the end of the stirring motor 2; the stirring The blade 4 is fixed on the stirring rod 3 and positioned in the liquid storage tank 15; the heating module assemblies 5 and 10 are respectively fixed to the periphery of the liquid storage tank 15 and the reaction chamber 13 for promoting vaporization of the reaction liquid; 6 is fixed to the top of the frame 1; the rotating disk 8 is fixed to the end of the rotating electrical machine 6 and located inside the reaction chamber 15; the fixing fixture 9 is fixed on the rotating disk 8; the pervaporation membrane module 14 is positioned In the interior of the reaction chamber 13, located upstream of
- the concentration of glutaraldehyde solution is 0.5 to 50. / o Mixing rod speed 0 - 200 rpm
- the artificial bioprosthesis was placed in a 0.625% glutaraldehyde solution for 10 days. Placed in a solution of glutaraldehyde for bioprosthetic valve is oscillated by way of the processing speed is 125 rpm 0
- Example 2 The present invention
- the stirring rod 3 and the stirring blade 4 are driven by the stirring motor 2 to agitate the 2% glutaraldehyde solution in the liquid storage tank 15, while the vacuum pump 12 is turned on so that the pressure of the reaction chamber 13 is 20 Pa.
- the pervaporation membrane module 14 is opened such that vaporized glutaraldehyde enters the reaction chamber 13 and permeates through the membrane module 14 to the artificial bioprosthesis, and the permeation rate of the membrane module is stabilized at about 50 g/(m 2 *hour).
- the present invention 13 ⁇ 89 ⁇ 0.7 92.07 ⁇ 7.5
- the pervaporation membrane module 10 of the present invention comprises one or more of a flat plate pervaporation membrane module, a hollow fiber pervaporation membrane module, and a roll pervaporation membrane module.
- the structure of the membrane module is well known in the art and will not be described in detail herein.
- the invention adopts a device and a method for membrane pervaporation fixed artificial biological valve, which can make the glutaraldehyde monomer enter the reaction region of the artificial biological valve at a constant rate, and at the same time, the reaction region of the artificial biological valve is in a low pressure environment.
- the artificial biological valve can better preserve the collagen fiber texture structure of the artificial biological valve during the chemical modification process.
- the device and method according to the present invention not only accelerates the chemical modification treatment time of the artificial biological valve, but also can better protect the collagen fiber texture structure of the artificial biological valve during the chemical modification process, thereby making the artificial biological valve obtained more. Good overall durability.
- the method and apparatus of the present invention employ glutaraldehyde as a chemical modifier.
- the apparatus and method of the present invention are equally applicable to other chemical modifiers such as formaldehyde and acetaldehyde.
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Water Supply & Treatment (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Manufacturing & Machinery (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Prostheses (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11874705.4A EP2772227B1 (en) | 2011-10-27 | 2011-12-15 | Method and device for fixing artificial bioprosthetic valve by membrane pervaporation |
AU2011379710A AU2011379710B2 (en) | 2011-10-27 | 2011-12-15 | Method and device for fixing artificial bioprosthetic valve by membrane pervaporation |
IN900KON2014 IN2014KN00900A (zh) | 2011-10-27 | 2011-12-15 | |
BR112014009974-0A BR112014009974B1 (pt) | 2011-10-27 | 2011-12-15 | dispositivo e método para fixação de uma válvula artificial de bioprótese por pervaporação através de membrana |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110332309.7A CN102423505B (zh) | 2011-10-27 | 2011-10-27 | 膜式渗透汽化式固定人工生物瓣的方法及装置 |
CN201110332309.7 | 2011-10-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2013060067A1 true WO2013060067A1 (zh) | 2013-05-02 |
Family
ID=45957589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CN2011/084056 WO2013060067A1 (zh) | 2011-10-27 | 2011-12-15 | 膜式渗透汽化式固定人工生物瓣的方法及装置 |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP2772227B1 (zh) |
CN (1) | CN102423505B (zh) |
AU (1) | AU2011379710B2 (zh) |
BR (1) | BR112014009974B1 (zh) |
IN (1) | IN2014KN00900A (zh) |
WO (1) | WO2013060067A1 (zh) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
US9554897B2 (en) | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
US9308087B2 (en) | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
US9345573B2 (en) | 2012-05-30 | 2016-05-24 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
US9572665B2 (en) | 2013-04-04 | 2017-02-21 | Neovasc Tiara Inc. | Methods and apparatus for delivering a prosthetic valve to a beating heart |
CN108882981B (zh) | 2016-01-29 | 2021-08-10 | 内奥瓦斯克迪亚拉公司 | 用于防止流出阻塞的假体瓣膜 |
EP3541462A4 (en) | 2016-11-21 | 2020-06-17 | Neovasc Tiara Inc. | METHODS AND SYSTEMS FOR RAPID RETRACTION OF A TRANSCATHETER HEART VALVE DELIVERY SYSTEM |
EP3672530A4 (en) | 2017-08-25 | 2021-04-14 | Neovasc Tiara Inc. | SEQUENTIALLY INSERTED TRANSCATHETER MITRAL VALVE PROSTHESIS |
EP3876870B1 (en) | 2018-11-08 | 2023-12-20 | Neovasc Tiara Inc. | Ventricular deployment of a transcatheter mitral valve prosthesis |
US11998447B2 (en) | 2019-03-08 | 2024-06-04 | Neovasc Tiara Inc. | Retrievable prosthesis delivery system |
JP7438236B2 (ja) | 2019-04-01 | 2024-02-26 | ニオバスク ティアラ インコーポレイテッド | 制御可能に展開可能な補綴弁 |
CA3136334A1 (en) | 2019-04-10 | 2020-10-15 | Neovasc Tiara Inc. | Prosthetic valve with natural blood flow |
CN114025813B (zh) | 2019-05-20 | 2024-05-14 | 内奥瓦斯克迪亚拉公司 | 具有止血机构的引入器 |
WO2020257643A1 (en) | 2019-06-20 | 2020-12-24 | Neovasc Tiara Inc. | Low profile prosthetic mitral valve |
CN111701078B (zh) * | 2020-04-20 | 2022-08-19 | 上海以心医疗器械有限公司 | 一种提高生物组织交联度的方法 |
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CN201244101Y (zh) * | 2008-07-03 | 2009-05-27 | 中国人民解放军第四军医大学 | 脉动生物反应器 |
US20100022677A1 (en) * | 2008-07-24 | 2010-01-28 | Zimmer, Inc. | Reduction of free radicals in crosslinked polyethylene by infrared heating |
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2011
- 2011-10-27 CN CN201110332309.7A patent/CN102423505B/zh active Active
- 2011-12-15 EP EP11874705.4A patent/EP2772227B1/en active Active
- 2011-12-15 BR BR112014009974-0A patent/BR112014009974B1/pt active IP Right Grant
- 2011-12-15 AU AU2011379710A patent/AU2011379710B2/en active Active
- 2011-12-15 WO PCT/CN2011/084056 patent/WO2013060067A1/zh active Application Filing
- 2011-12-15 IN IN900KON2014 patent/IN2014KN00900A/en unknown
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See also references of EP2772227A4 |
Also Published As
Publication number | Publication date |
---|---|
CN102423505A (zh) | 2012-04-25 |
EP2772227A1 (en) | 2014-09-03 |
EP2772227A4 (en) | 2015-04-15 |
BR112014009974A2 (pt) | 2017-05-30 |
EP2772227B1 (en) | 2017-09-06 |
IN2014KN00900A (zh) | 2015-10-09 |
BR112014009974B1 (pt) | 2020-11-10 |
AU2011379710A1 (en) | 2014-05-15 |
AU2011379710B2 (en) | 2015-09-03 |
CN102423505B (zh) | 2014-12-10 |
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