WO2013058613A3 - 2-하이드록시아릴아마이드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 암 예방 또는 치료용 약학적 조성물 - Google Patents

2-하이드록시아릴아마이드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 암 예방 또는 치료용 약학적 조성물 Download PDF

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WO2013058613A3
WO2013058613A3 PCT/KR2012/008626 KR2012008626W WO2013058613A3 WO 2013058613 A3 WO2013058613 A3 WO 2013058613A3 KR 2012008626 W KR2012008626 W KR 2012008626W WO 2013058613 A3 WO2013058613 A3 WO 2013058613A3
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cancer
hydroxyarylamide
preventing
derivative
pharmaceutically acceptable
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PCT/KR2012/008626
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English (en)
French (fr)
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WO2013058613A2 (ko
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김세미
이일영
민혜진
남은희
김필호
윤창수
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한국생명공학연구원
한국화학연구원
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Priority claimed from KR1020120116733A external-priority patent/KR101434461B1/ko
Publication of WO2013058613A2 publication Critical patent/WO2013058613A2/ko
Publication of WO2013058613A3 publication Critical patent/WO2013058613A3/ko
Priority to US14/256,808 priority Critical patent/US9266872B2/en

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    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • A—HUMAN NECESSITIES
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    • C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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Abstract

본 발명은 2-하이드록시아릴아마이드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 암 예방 또는 치료용 약학적 조성물에 관한 것이다. 본 발명에 의해 제조된 2-하이드록시아릴아마이드 유도체 화합물은 TMPRSS4 세린프로테아제 활성 저해 효과와 TMPRSS4 발현 암세포 침윤 억제효과가 매우 우수하므로 암 세포, 특히, 대장암, 폐암, 유방암, 전립선암, 난소암, 췌장암 또는 위암 세포 등에서 과발현되는 TMPRSS4를 저해함으로써, 암의 예방 또는 치료용 조성물로 유용하게 사용될 수 있다.
PCT/KR2012/008626 2011-10-21 2012-10-19 2-하이드록시아릴아마이드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 암 예방 또는 치료용 약학적 조성물 WO2013058613A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US14/256,808 US9266872B2 (en) 2011-10-21 2014-04-18 2-hydroxyarylamide derivative or pharmaceutically acceptable salt thereof, preparation method thereof, and pharmaceutical composition for preventing or treating cancer containing same as active ingredient

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2011-0107934 2011-10-21
KR20110107934 2011-10-21
KR10-2012-0116733 2012-10-19
KR1020120116733A KR101434461B1 (ko) 2011-10-21 2012-10-19 2-하이드록시아릴아마이드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 암 예방 또는 치료용 약학적 조성물

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US14/256,808 Continuation-In-Part US9266872B2 (en) 2011-10-21 2014-04-18 2-hydroxyarylamide derivative or pharmaceutically acceptable salt thereof, preparation method thereof, and pharmaceutical composition for preventing or treating cancer containing same as active ingredient

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WO2013058613A2 WO2013058613A2 (ko) 2013-04-25
WO2013058613A3 true WO2013058613A3 (ko) 2013-06-13

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Publication number Priority date Publication date Assignee Title
KR101434461B1 (ko) * 2011-10-21 2014-09-01 한국생명공학연구원 2-하이드록시아릴아마이드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 암 예방 또는 치료용 약학적 조성물
JP2017511340A (ja) * 2014-03-31 2017-04-20 ザ トラスティース オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク ヒストンアセチルトランスフェラーゼ活性剤及びその使用
CN117105810B (zh) * 2023-10-23 2024-02-09 中国农业大学 一种具有广谱抗菌活性的化合物及其抗菌组合物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6299329A (ja) * 1983-08-24 1987-05-08 ユニリ−バ−・ナ−ムロ−ゼ・ベンノ−トシヤ−プ 皮膚用抗炎症組成物
WO2001098290A2 (en) * 2000-06-19 2001-12-27 Pharmacia Italia S.P.A. Thiophene derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
WO2002076918A1 (en) * 2001-03-27 2002-10-03 Suntory Limited NF-λB INHIBITOR CONTAINING SUBSTITUTED BENZOIC ACID DERIVATIVE AS ACTIVE INGREDIENT
WO2003103655A1 (ja) * 2002-06-10 2003-12-18 株式会社医薬分子設計研究所 癌治療剤

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6299329A (ja) * 1983-08-24 1987-05-08 ユニリ−バ−・ナ−ムロ−ゼ・ベンノ−トシヤ−プ 皮膚用抗炎症組成物
WO2001098290A2 (en) * 2000-06-19 2001-12-27 Pharmacia Italia S.P.A. Thiophene derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
WO2002076918A1 (en) * 2001-03-27 2002-10-03 Suntory Limited NF-λB INHIBITOR CONTAINING SUBSTITUTED BENZOIC ACID DERIVATIVE AS ACTIVE INGREDIENT
WO2003103655A1 (ja) * 2002-06-10 2003-12-18 株式会社医薬分子設計研究所 癌治療剤

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