WO2013033973A1 - 超声波震荡机 - Google Patents

超声波震荡机 Download PDF

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Publication number
WO2013033973A1
WO2013033973A1 PCT/CN2012/001242 CN2012001242W WO2013033973A1 WO 2013033973 A1 WO2013033973 A1 WO 2013033973A1 CN 2012001242 W CN2012001242 W CN 2012001242W WO 2013033973 A1 WO2013033973 A1 WO 2013033973A1
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Prior art keywords
disposed
ultrasonic
accommodating groove
machine according
cover body
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Application number
PCT/CN2012/001242
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English (en)
French (fr)
Inventor
黄玲惠
Original Assignee
Huang Lynn L H
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Application filed by Huang Lynn L H filed Critical Huang Lynn L H
Priority to JP2014527464A priority Critical patent/JP5860537B2/ja
Priority to KR1020147008808A priority patent/KR101602812B1/ko
Priority to AU2012306946A priority patent/AU2012306946B2/en
Priority to CN201280042779.2A priority patent/CN103764275B/zh
Priority to CA2850556A priority patent/CA2850556C/en
Priority to EP12829878.3A priority patent/EP2754487B1/en
Publication of WO2013033973A1 publication Critical patent/WO2013033973A1/zh
Priority to IN2537CHN2014 priority patent/IN2014CN02537A/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J19/10—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing sonic or ultrasonic vibrations
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/275—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of animal origin, e.g. chitin
    • A23L29/281—Proteins, e.g. gelatin or collagen
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/275—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of animal origin, e.g. chitin
    • A23L29/281—Proteins, e.g. gelatin or collagen
    • A23L29/284—Gelatin; Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli

Definitions

  • the present invention is an ultrasonic oscillator, and more particularly to an ultrasonic oscillator for fabricating a collagen matrix. Background technique
  • an object of the present invention is to design an ultrasonic oscillating machine to mass-produce a collagen matrix from connective tissue.
  • the technical means employed in the present invention is to design an ultrasonic oscillator comprising:
  • each oscillating device being coupled to the corresponding frame and selectively vibrating the corresponding frame;
  • An ultrasonic structure is disposed in the body.
  • the transmission assembly includes a hydraulic cylinder, a cover body and a plurality of support rods.
  • the hydraulic cylinder is disposed at the top of the body, and the cover body is connected to the hydraulic cylinder and selectively closes the accommodating groove.
  • a plurality of support rods extend through the top of the body and the cover body and are connected to the hydraulic cylinders, and the plurality of frames are respectively hung on the support rods.
  • each of the oscillating devices includes a spur gear, a motor and an eccentric gear.
  • the spur gear is fixed on the corresponding support rod
  • the motor is disposed on the body
  • the eccentric gear is driven by the motor and selected sexually mesh with the corresponding spur gear.
  • a vacuum pump is further disposed, and the vacuum pump is disposed on the cover body, and the cover body is provided with a pressure release device.
  • the ultrasonic oscillating machine further includes a spray structure disposed in the accommodating groove, and a drain pipe is disposed at the bottom of the accommodating groove, and the drain pipe extends out of the body.
  • the invention has the advantages that the connection between the oscillating device and the ultrasonic structure can make the connective tissue accommodated in the container gradually become a collagen-based shield by the action of vibration and ultrasonic waves, thereby providing the current industrial demand.
  • Figure 1 is a front view of the movement of the support rod of the present invention
  • Figure 2 is an enlarged side elevational view of the container of the present invention
  • Figure 3 is a front view of the frame vibration of the present invention.
  • Figure 4 is another front view of the frame vibration of the present invention. detailed description
  • the present invention comprises a hollow body 10, a receiving groove 20, and a transmission assembly.
  • the accommodating groove 20 is fixed in the body 10 and disposed adjacent to the bottom of the body 10.
  • the bottom of the accommodating groove 20 is provided with a drain pipe 21 extending outside the body 10.
  • the aforementioned transmission assembly 30 is disposed at the top of the body 10, and the transmission assembly 30 includes a hydraulic cylinder.
  • the hydraulic cylinder 31 is disposed at the top of the body 10.
  • the cover body 32 is connected to the hydraulic cylinder 31 and selectively closes the accommodating groove 20.
  • the cover body 32 is provided with a pressure release.
  • the device 321 has a support rod 33 penetrating the top of the body 10 and the cover 32, and the support rod 33 is connected to the hydraulic cylinder 31.
  • the plurality of frames 40 are connected to the transmission assembly 30 and selectively disposed in the receiving slots 20.
  • the plurality of frames 40 are respectively suspended.
  • a plurality of containers 41 are formed in each of the frames 40 on the support rods 33, and a plurality of perforations 411 are formed in each of the containers 41.
  • Each of the oscillating devices 50 is connected to the corresponding frame 40, and each of the oscillating devices 50 selectively vibrates the corresponding frame 40.
  • Each of the oscillating devices 50 respectively has a spur gear 51 and a motor 52.
  • An eccentric gear 53 is fixed to the corresponding support rod 33.
  • the motor 52 is disposed on the body 10.
  • the eccentric gear 53 is driven by the motor 52 and selectively meshes with the corresponding spur gear 51.
  • the aforementioned ultrasonic structure 60 is disposed in the body 10.
  • the aforementioned vacuum pump 70 is disposed on the cover 32 and selectively extracts air in the accommodating groove 20 to form a vacuum state in the accommodating groove 20.
  • the spray structure 80 is disposed in the accommodating groove 20 and selectively sprinkling water to wet the substance in the container 41.
  • the water sprayed into the accommodating groove 20 is discharged through the drain pipe 21, and the spray structure 80 may include a plurality of nozzles. .
  • the connective tissue 90 is placed in the container 41, and the hydraulic cylinder 31 pushes the cover 32 downward to close the receiving groove 20, and the frame 40 is also moved into the receiving groove 20.
  • the vacuum pump 70 can form a vacuum state in the accommodating groove 20.
  • the eccentric gear 53 meshes with the spur gear 51, and the motor 52 is actuated to rotate the eccentric gear 53 to drive the spur gear 51 to rotate up and down. Therefore, the support rod 33 is oscillated. The vibration causes the frame 40 and the container 41 to vibrate. At this time, the ultrasonic structure 60 and the spray structure 80 are simultaneously actuated, and the connective tissue in the container 41 gradually becomes a collagen matrix.
  • the pressure release device 321 is activated to allow outside air to enter the accommodating groove 20, and the hydraulic cylinder 31 can pull the cover 32 and the frame 40 to move upward and away from the accommodating groove 20, and the manufacturer can take out the ejector groove 20 at this time.
  • the container 41 in the frame 40 is taken out to obtain a finished product.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Dispersion Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Prostheses (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)
  • External Artificial Organs (AREA)
  • Special Spraying Apparatus (AREA)

Abstract

一种用来制造胶原基质的超声波震荡机，其具有一中空本体（10）、一容置槽（20）、一传动组件（30）、多个框架（40）、多个震荡装置（50）及一超声波机构（60），容置槽（20）设置于本体（10）中，框架（40）与传动组件（30）相接，传动组件（30）带动框架（40）使其远离或置入容置槽（20）中，震荡装置（50）分别与框架（40）相连接，超声波机构（60）设于容置槽（20）中，在制程中，启动震荡装置（50）与超声波机构（60）以产生作用，则容置槽（20）中的结缔组织将逐渐变成胶原基质。

Description

超声波震荡机 技术领域
本发明为一种超声波震荡机， 特别涉及一种用来制造胶原基质的超声波震 荡机。 背景技术
现今社会中广泛的使用胶原蛋白， 生物科技产业致力于发展快速制造高品 质胶原蛋白的技术， 因此， 由结締组织来制造胶原基质成为重要的研究议题。 发明内容
有鉴于此， 本发明的目的是设计一种超声波震荡机， 以由结締组织来大量 制造胶原基质。
为达到上述的发明目的， 本发明所釆用的技术手段为设计一种超声波震荡 机， 其包括：
一中空的本体；
一容置槽， 其固设于本体中；
一传动组件， 其穿设于本体；
多个框架， 其与传动组件相连接且选择性地设于容置槽中， 各框架中设有 多个容器；
多个震荡装置， 各震荡装置与相对应的框架连接且选择性地震动相对应的 框架；
一超声波结构， 其设于本体中。
所述的超声波震荡机， 其中， 传动组件包含有一液压缸、 一盖体及多个支 撑杆， 液压缸设于本体的顶部， 盖体与液压缸相连接且选择性地封闭容置槽， 该多个支撑杆贯穿本体的顶部及盖体且与液压缸相连接， 该多个框架分别挂设 于支撑杆上。
所述的超声波震荡机， 其中， 各震荡装置分别包含有一正齿轮、 一马达及 一偏心齿轮， 正齿轮固设于相对应的支撑杆上， 马达设于本体上， 偏心齿轮受 马达驱动且选择性地与相对应的正齿轮相啮合。 所述的超声波震荡机， 其中， 进一步包舍有一真空泵， 该真空泵设于盖体 上， 盖体上设有一压力释放装置。
所述的超声波震荡机， 其中， 进一步包含有一喷洒结构， 该喷洒结构设于 容置槽中， 容置槽底部设有一排水管， 该排水管延伸出本体外。
本发明的优点在于， 通过震荡装置与超声波结构的配合， 可使容器中所容 纳的结締组织通过震荡及超声波的作用来逐渐变成胶原基盾， 因此， 可加以提 供目前产业上的需求。 附图说明
图 1为本发明支撑杆向下移动的前视动作图；
图 2为本发明容器的放大侧视图；
图 3为本发明框架震动的前视动作图；
图 4为本发明框架震动的另一前视动作图。 具体实施方式
以下配合附图及本发明的较佳实施例， 进一步阐述本发明为达成预定发明 目的所釆取的技术手段。
请参阅图 1所示， 本发明包含有一中空本体 10、 一容置槽 20、 一传动组件
30、 多个框架 40、 多个震荡装置 50、 一超声波机构 60、 一真空泵 70及一喷洒 结构 80。
前述的容置槽 20固设于本体 10中且设置于邻近本体 10的底部处，容置槽 20的底部设有一排水管 21， 该排水管 21延伸出本体 10外。
前述的传动组件 30穿设于本体 10的顶部， 传动组件 30包含有一液压缸
31、 一盖体 32及多个支撑杆 33 , 液压缸 31设于本体 10的顶部， 盖体 32与液 压缸 31相连接且选择性地封闭容置槽 20 , 盖体 32上设有一压力释放装置 321， 支撑杆 33贯穿本体 10的顶部及盖体 32， 且支撑杆 33与液压缸 31相连接。
请参阅图 1及图 2所示， 前述的该多个框架 40与传动组件 30相连接且选 择性地设于容置槽 20中， 在较佳实施例中， 该多个框架 40分别挂设于支撑杆 33上， 各框架 40中设有多个容器 41， 各容器 41中穿设成形有多个穿孔 411。 前述的各震荡装置 50与相对应的框架 40相连接，且各震荡装置 50选择性 地震动相对应的框架 40， 各震荡装置 50分别包舍有一正齿轮 51、 一马达 52及 一偏心齿轮 53 , 正齿轮 51固设于相对应的支撑杆 33 , 马达 52设于本体 10上， 偏心齿轮 53受马达 52驱动且选择性地与相对应的正齿轮 51相啮合。
前述的超声波结构 60设于本体 10中。
前述的真空泵 70设于盖体 32上且选择性地抽取容置槽 20中的空气以使容 置槽 20中形成真空状态。
前述的喷洒结构 80设于容置槽 20中且选择性地洒水以湿润容器 41中的物 质， 喷入容置槽 20中的水将经由排水管 21排出， 喷洒结构 80可包含有多个喷 嘴。
请参阅图 1及图 2所示， 将结締组织 90置于容器 41中， 液压缸 31推动盖 体 32向下移动并封闭容置槽 20， 此时框架 40亦移动入容置槽 20中， 当盖体 32封闭容置槽 20后， 真空泵 70可将容置槽 20中形成真空状态。
请参阅图 3及图 4所示， 此时偏心齿轮 53与正齿轮 51相啮合， 马达 52作 动使得偏心齿轮 53加以转动， 进而带动正齿轮 51转动而产生上下震荡， 因此， 支撑杆 33的震荡使得框架 40及容器 41产生震动， 此时超声波结构 60及喷洒 结构 80亦同时作动， 则容器 41中的结締组织逐渐变成胶原基质。
当前述的制程完成时， 启动压力释放装置 321以使外部空气进入容置槽 20 中， 则液压缸 31得以拉动盖体 32及框架 40向上移动并离开容置槽 20， 此时制 造者可取出将框架 40中的容器 41取出以获得成品。
以上所述仅是本发明的较佳实施例而已， 并非对本发明做任何形式上的限 制， 虽然本发明已以较佳实施例揭露如上， 然而并非用以限定本发明， 任何熟 悉本专业的技术人员， 在不脱离本发明技术方案的范围内， 当可利用上述揭示 的技术内容作出些许更动或修饰为等同变化的等效实施例， 但凡是未脱离本发 明技术方案的内容， 依据本发明的技术实质对以上实施例所作的任何简单修改、 等同变化与修饰， 均仍属于本发明技术方案的范围内。

Claims

权 利 要 求
1.一种超声波震荡机， 其特征在于， 包括：
一中空的本体；
一容置槽， 其固设于本体中；
一传动组件， 其穿设于本体；
多个框架， 其与传动组件相连接且选择性地设于容置槽中， 各框架中设有 多个容器；
多个震荡装置， 各震荡装置与相对应的框架连接且选择性地震动相对应的 框架；
一超声波结构， 其设于本体中。
2.如权利要求 1所述的超声波震荡机， 其特征在于， 传动组件包含有一液 压缸、 一盖体及多个支撑杆， 液压缸设于本体的顶部， 盖体与液压缸相连接且 选择性地封闭容置槽， 该多个支撑杆贯穿本体的顶部及盖体且与液压缸相连接， 该多个框架分别挂设于支撑杆上。
3.如权利要求 2所述的超声波震荡机， 其特征在于， 各震荡装置分别包含 有一正齿轮、 一马达及一偏心齿轮， 正齿轮固设于相对应的支撑杆上， 马达设 于本体上， 偏心齿轮受马达驱动且选择性地与相对应的正齿轮相啮合。
4.如权利要求 1至 3中任一项所述的超声波震荡机， 其特征在于， 进一步 包含有一真空泵， 该真空泵设于盖体上， 盖体上设有一压力释放装置。
5.如权利要求 1至 3中任一项所述的超声波震荡机， 其特征在于， 进一步 包含有一喷洒结构， 该喷洒结构设于容置槽中， 容置槽底部设有一排水管， 该 排水管延伸出本体外。
6.如权利要求 4所述的超声波震荡机， 其特征在于， 进一步包含有一喷洒 结构， 该喷洒结构设于容置槽中， 容置槽底部设有一排水管， 该排水管延伸出 本体外。
PCT/CN2012/001242 2011-09-06 2012-09-05 超声波震荡机 WO2013033973A1 (zh)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2014527464A JP5860537B2 (ja) 2011-09-06 2012-09-05 超音波発振器
KR1020147008808A KR101602812B1 (ko) 2011-09-06 2012-09-05 초음파 발진기
AU2012306946A AU2012306946B2 (en) 2011-09-06 2012-09-05 Ultrasonic oscillator
CN201280042779.2A CN103764275B (zh) 2011-09-06 2012-09-05 超声波震荡机
CA2850556A CA2850556C (en) 2011-09-06 2012-09-05 Ultrasonic oscillator
EP12829878.3A EP2754487B1 (en) 2011-09-06 2012-09-05 Ultrasonic oscillator
IN2537CHN2014 IN2014CN02537A (zh) 2011-09-06 2014-04-03

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CA2850556A1 (en) 2013-03-14
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TWI475108B (zh) 2015-03-01
EP2754487A4 (en) 2015-04-22
EP2754487A1 (en) 2014-07-16
KR101602812B1 (ko) 2016-03-11
KR20140073516A (ko) 2014-06-16
CN103764275B (zh) 2015-05-20
CN103764275A (zh) 2014-04-30
AU2012306946B2 (en) 2015-12-03
TW201311887A (zh) 2013-03-16
CA2850556C (en) 2016-06-21
JP5860537B2 (ja) 2016-02-16
IN2014CN02537A (zh) 2015-08-07

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